CURRENT ISSUE
March, 2026
No. 111 (3)

Editorials

7

Review Articles

2

Articles

17
Acute Lymphoblastic Leukemia

NFATc1 and NFATc2 regulate glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia through modulation of cholesterol biosynthesis and the WNT/β-catenin pathway (1118 Online Views)

Giulia Veltri, Alberto Peloso, Alice Cani, Elena Mariotto, Diana Corallo, Sanja Aveic, Loris Russo, Matilde Cescon, Giulia Santinon, Chiara Frasson, Katharina Simon, Alberto Arrighi, Egidio Iorio, Sonia Anna Minuzzo, Stefano Indraccolo, Sandra Marmiroli, Panagiotis Ntziachristos, Alessandra Biffi, Martina Pigazzi, Barbara Buldini, Silvia Bresolin, Valentina Serafin

https://doi.org/10.3324/haematol.2025.287651

Acute Myeloid Leukemia

Real-world validation study of the LSC17 score for risk prediction in patients with newly diagnosed acute myeloid leukemia (2133 Online Views)

Tracy Murphy, Boyang Zhang, Tong Zhang, Ian King, Jose-Mario Capo-Chichi, Vikas Gupta, Dawn Maze, Caroline J. McNamara, Mark D. Minden, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen W.L. Yee, Andrea Arruda, Zhibin Lu, Dina Khalaf, Chantal Rockwell, Brian Leber, Mitchell Sabloff, Anne Tierens, Tracy L. Stockley, Steven M. Chan, Stanley W.K. Ng, Jean C.Y. Wang

https://doi.org/10.3324/haematol.2025.287777

Clinical activity of venetoclax and azacitidine in children with de novo or secondary multiple relapsed/refractory acute myeloid leukemia: a real-world experience (1158 Online Views)

Agathe Arcourt, Uri Ilan, Laura Murillo, Nira Arad-Cohen, Alba Rubio, Sarah K. Tasian, André Baruchel, Michel C. Zwaan, Stephane Ducassou, Bianca F. Goemans

https://doi.org/10.3324/haematol.2025.288246

Blood Transfusion

Caffeine impairs red blood cell storage quality by dual inhibition of ADORA2b signaling and G6PD activity (6606 Online Views)

Monika Dzieciatkowska, Ariel Hay, Aaron Issaian, Gregory R. Keele, Shaun Bevers, Travis Nemkov, Julie A. Reisz, Mark Maslanka, Daniel Stephenson, Amy L. Moore, Xutao Deng, Mars Stone, Kirk C. Hansen, Steve Kleinman, Philip J. Norris, Michael P. Busch, Grier P. Page, Nareg Roubinian, Yang Xia, James C. Zimring, Angelo D’Alessandro

https://doi.org/10.3324/haematol.2025.288332

Cell Therapy & Immunotherapy

Safety and efficacy of bridging radiation therapy prior to CD19 CAR T for non-Hodgkin lymphoma: a systematic review and meta-analysis (2915 Online Views)

Mohammad Alhomoud, Rahma Ibrahim, Michelle Demetres, Kai Rejeski, Michael Scordo, Roni Shouval, Tobias Tix, Jeremie Martinet, Michelle Foley, Alexandra Gomez-Arteaga, Tsiporah Shore, Paul Pagnini, Mahmoud Aljurf, Monica L. Guzman, Silvia Formenti, Joachim Yahalom, Koen van Besien, Brandon S. Imber, Zhengming Chen, Samuel Yamshon

https://doi.org/10.3324/haematol.2025.287547

Cell Therapy and Immunotherapy

Chronic Myeloid Leukemia

Olverembatinib in accelerated-phase chronic myeloid leukemia: efficacy and safety evaluation (968 Online Views)

Mengyao Yuan, Li Zhou, Weiming Li, Xin Du, Jianyu Weng, Linhua Yang, Yanping Ma, Bingcheng Liu, Zhenfang Liu, Qin Wen, Shasha Zhao, Yanli Zhang, Qingxian Bai, Xianqi Feng, Yanqiu Han, Chunshui Liu, Li Meng, Baohong Wang, Xuehong Ran, Xiaodong Wang, Haiguo Zhang, Yun Zeng, Qing Leng, Lu Yu, Zongru Li, Robert Peter Gale, Xiaojun Huang, Qian Jiang

https://doi.org/10.3324/haematol.2025.288249

Interim analysis of a multicenter study on patient-guided dose reduction of tyrosine kinase inhibitors in chronic myeloid leukemia: the RODEO study (801 Online Views)

Dina Nienke Lokhorst, Yolba Smit, Bart J.F. van den Bemt, Rosella P.M.G. Hermens, Marten R. Nijziel, Asiong K-S. Jie, Laura G.M. Daenen, Saskia K. Klein, Eduardus F.M. Posthuma, Peter E. Westerweel, Marjolein Donker, Mels Hoogendoorn, Charlotte L. Bekker, Nicole M.A. Blijlevens

https://doi.org/10.3324/haematol.2025.288516

Coagulation & its Disorders

Platelet-driven monocyte activation promotes hypoxic thromboinflammation through the HIF-1α-NLRP3-EGR-1 axis (986 Online Views)

Shankar Chanchal, Kashika Singh, Raishal Safdar, Syed Mohd, Tashi Thinlas, Sayeed Ahmad, Tathagata Chatterjee, Mohammad Zahid Ashraf

https://doi.org/10.3324/haematol.2025.287317

Ex vivo correction of severe coagulation Factor VII deficiency in patient-derived 3D liver organoids (864 Online Views)

Giacomo Roman, Knut H. Lauritzen, Sean P. Harrison, Anindita Bhattacharya, Marianne Seierstad Andresen, Marie-Christine Mowinckel, Barbora Smolkova, Carola E. Henriksson, Heidi Glosli, Nina Iversen, Bernd Thiede, Gareth J. Sullivan, Runar Almaas, Per Morten Sandset, Benedicte Stavik, Maria E. Chollet

https://doi.org/10.3324/haematol.2025.288046

Complications in Hematology

Hematopoietic Cell Transplantation

Integrating killer cell immunoglobulin-like receptor highresolution genotyping for predicting transplant outcomes in allogeneic hematopoietic stem cell transplantation (1975 Online Views)

Antonia Schäfer, Stéphane Buhler, Ticiana D.J. Farias, Katherine M. Kichula, Helen Baldomero, Zuleika Calderin Sollet, Sylvie Ferrari-Lacraz, Baptiste Micheli, Stavroula Masouridi-Levrat, Vanessa Mesquita, Oliver Kürsteiner, Gayathri Nair, Jörg Halter, Tayfun Güngör, Dominik Schneidawind, Yves Chalandon, Jakob R. Passweg, Paul J. Norman, Jean Villard

https://doi.org/10.3324/haematol.2024.287061

Selection of unrelated donors for allogeneic transplantation using post-transplant cyclophosphamide in acute lymphoblastic leukemia: an analysis by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (1695 Online Views)

Jaime Sanz, Allain-Thibeault Ferhat, Alexander Kulagin, Nicolaus Kröger, Montserrat Rovira, Lorenzo Lazzari, Mutlu Arat, Juan Montoro, Jurjen Versluis, Péter Reményi, Simona Sica, Didier Blaise, Muhammad Ameer Saif, Jan Vydra, Franca Fagioli, Erfan Nur, Sebastian Giebel, Zina Peric, Eolia Brissot, Arnon Nagler, Simona Piemontese, Mohamad Mohty, Fabio Ciceri

https://doi.org/10.3324/haematol.2025.287750

Myeloproliferative Disorders

Loss of life expectancy in patients with myeloproliferative neoplasms in Sweden (926 Online Views)

Yuliya Leontyeva, Anna Ravn Landtblom, Malin Hultcrantz, Mats Lambe, Hannah Bower, Paul C. Lambert, Therese M-L. Andersson

https://doi.org/10.3324/haematol.2024.286697

A retrospective analysis of upfront treatment strategies in chronic myelomonocytic leukemia: impact on survival and response patterns (593 Online Views)

Muhammad Yousuf, Priyansh Faldu, Maymona Abdelmagid, Fnu Aperna, Saubia Fathima, Ali Khalid A. Alsugair, Clifford M. Csizmar, Terra L. Lasho, Abhishek A. Mangaonkar, Kaaren K. Reichard, Rong He, Animesh Pardanani, Naseema Gangat, Mrinal M. Patnaik., Ayalew Tefferi

https://doi.org/10.3324/haematol.2025.288006

Non-Hodgkin Lymphoma

Prognostic value of tumor bulk in modern management of common lymphoma subtypes: an Australasian Lymphoma and Related Diseases Registry study (778 Online Views)

Eliza Chung, Luke Wang, Cameron Wellard, Allison Barraclough, Belinda A. Campbell, Geoffrey Chong, Pietro Di Ciaccio, Gareth P. Gregory, Greg Hapgood, Anna M. Johnston, Constantine S. Tam, Stephen Opat, Erica M. Wood, Zoe K. McQuilten, Eliza A. Hawkes

https://doi.org/10.3324/haematol.2025.287919

Plasma Cell Disorders

Hepatitis E virus infections in people with multiple myeloma: an emerging challenge in the era of immunotherapeutic approaches (909 Online Views)

Maximilian Al-Bazaz, Sven Pischke, Winfried Alsdorf, Piet Sonnemann, Sophia Cichutek, Julian Schulze zur Wiesch, Christoph Schaefers, Jule Artzenroth, Lisa Leypoldt, Abdulaziz Kamili, Carsten Bokemeyer, Katja Weisel, Ricardo Kosch

https://doi.org/10.3324/haematol.2025.288381

Letters to the Editor

17

Brentuximab vedotin plus nivolumab as bridging therapy to CAR T-cells in relapsed/refractory primary mediastinal B-cell lymphoma (878 Online Views)

Armando Santoro, Ciro Maria Improta, Barbara Sarina, Daniele Mannina, Chiara De Philippis, Daniela Taurino, Jacopo Mariotti, Monica Balzarotti, Stefania Bramanti

https://doi.org/10.3324/haematol.2025.287672

Blinatumomab restores asparaginase activity in pediatric B-cell acute lymphoblastic leukemia patients with PEGasparaginase hypersensitivity (1297 Online Views)

Xue Tang, Lingying Zhao, Wujiao Li, Shilin Liu, Xuejuan Li, Lixiang Zhu, Duocai Wang, Shiyang Chen, Zhaonan Liu, Sixi Liu, Feiqiu Wen, Oussama Abla, Ying Wang, Huirong Mai, Xiaoying Fu

https://doi.org/10.3324/haematol.2025.287910

Ovarian tissue autotransplantation in acute leukemia: balancing the risk of relapse and the hope of parenthood (1570 Online Views)

Florian Chevillon, Elsa Labrune, Emmanuelle Clappier, Hélène Lapillonne, Paola Ballerini, Virginie Barraud Lange, Anne Fortin, Raphael Itzykson, Gérard Socié, Agnès Buzyn, Guy Leverger, Jean-Hugues Dalle, Nathalie Dhédin, Nicolas Boissel, Régis Peffault de Latour, Bruno Salle, Christophe Roux, Catherine Poirot

https://doi.org/10.3324/haematol.2025.287942

Intravenous immunoglobulins in the management of acute chest syndrome in two Jehovah’s Witnesses with sickle cell disease (535 Online Views)

Francesca Begali, Jacopo Ceolan, Silvia Vitale, Simone Villaboni, Matteo Merlo, Rachele Zamperini, Roberto Bertazzo, Soraia Ribeiro Luz, Filippo Mazzi, Lucia De Franceschi

https://doi.org/10.3324/haematol.2025.287956

Wild-type p53 overexpression in NPM1-mutated acute myeloid leukemia: potential implications for disease biology and therapy response (1356 Online Views)

Paul D. Barone, Siarhei Dzedzik, Ashley S. Kleinman, Christopher R. Chin, Cem Meydan, Itzel Valencia, Mayumi Sugita, Monica L. Guzman, Joshua A. Fein, Justin D. Kaner, Pinkal Desai, Gail J. Roboz, Ari M. Melnick, Christopher E. Mason, Sanjay S. Patel

https://doi.org/10.3324/haematol.2025.288054

Impact of demographic factors on clinical outcomes of patients with acute myeloid leukemia (730 Online Views)

Cassandra Duarte, Diana Abbot, Grace Bosma, Andrew Kent, Marc Schwartz, Cailin Collins, Mathew G. Angelos, Christine McMahon, Jonathon Gutman, Daniel A. Pollyea, Maria Amaya

https://doi.org/10.3324/haematol.2025.288131

Venetoclax plus hypomethylating agents as a bridge to transplant or donor lymphocyte infusion in relapsed/ refractory acute myeloid leukemia (1312 Online Views)

Kathelijn Verdeyen, Tom Reuvekamp, Walter J.F.M. van der Velden, Bas J. Wouters, Peter A. von dem Borne, Anna van Rhenen, Birgit I. Lissenberg-Witte, Daniëlle van Lammeren, Geerte L. van Sluis, Eva de Jongh, Roel B. Fiets, Maarten F. Corsten, Arie C. van der Spek, Anke M. Gerrits, Esther R. van Bladel, Lidwine W. Tick, Okke de Weerdt, Bregje van Zaane, Marjan J. Cruijsen, Eduardus F.M. Posthuma, Catharina H.M.J. van Elssen, Saskia K. Klein, Arjan A. van de Loosdrecht, David C. de Leeuw

https://doi.org/10.3324/haematol.2025.288178

Impact of letermovir on cytomegalovirus-specific T-cell reconstitution after allogeneic hematopoietic stem cell transplantation in the post-transplant cyclophosphamide era (1172 Online Views)

Elena Tassi, Giorgio Orofino, Valeria Beretta, Veronica Valtolina, Gregorio Maria Bergonzi, Maddalena Noviello, Elisabetta Xue, Matteo Doglio, Andrea Acerbis, Lorenzo Lazzari, Fabio Giglio, Simona Piemontese, Elisa Diral, Alessandro Bruno, Francesca Farina, Raffaele Dell’Acqua, Luca Vago, Andrea Assanelli, Annalisa Ruggeri, Daniela Clerici, Consuelo Corti, Maria Teresa Lupo-Stanghellini, Fabio Ciceri, Chiara Bonini, Raffaella Greco

https://doi.org/10.3324/haematol.2025.288306

The co-inheritance of two ITGB3 variants with additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia (464 Online Views)

Nina Arndt, Emanuela Falcinelli, Ana Zamora-Canovas, Ana Sanchez Fuentes, Ana Marin-Quilez, Maria Del Mar Nieto-Hernandez, Jose Rivera, Paolo Gresele, Loredana Bury

https://doi.org/10.3324/haematol.2025.288369

Rapid and durable recovery of immune effector cells in myelofibrosis patients treated with momelotinib (967 Online Views)

Jasmine Makker, Kyaw Htin Thaw, Amna Sheikh, Llywelyn Cadman-Davies, Andrea Duminuco, Elena Torre, Margherita Panetta, Conor Stanley, Hugues de Lavallade, Natalia Curto-Garcia, Priya Sriskandarajah, Jennifer O'Sullivan, Deepti H. Radia, Claire Woodley, Benissa Narciso, Susan Asirvatham, Bethan Psaila, Shahram Kordasti, Claire Harrison, Patrick Harrington

https://doi.org/10.3324/haematol.2025.288515

Real-world safety and efficacy of rADAMTS13 prophylaxis in congenital thrombotic thrombocytopenic purpura: experience from Polish patients previously treated with fresh frozen plasma (717 Online Views)

Jerzy Windyga, Joanna Zdziarska, Magdalena Górska-Kosicka, Adela Gwozdowska, Miłosz Jazdon, Paweł Łaguna, Maria Szczepańska, Magdalena Wojdalska, Danuta Pietrys, Michał Taszner, Michał Witkowski, Beata Baran, Wojciech Młynarski

https://doi.org/10.3324/haematol.2025.288561

The added value of Bayesian interim analysis in randomized phase II and phase III clinical trials in hemato-oncology (504 Online Views)

Anna J.T. Smit, Niek G. van der Maas, Bronno van der Holt, Yvette van Norden, Erik van Werkhoven, Annette Juul Vangsted, Paula F. Ypma, Heleen A. Visser-Wisselaar, Rossella Troia, Mario Boccadoro, Bob Löwenberg, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Fredrik Schjesvold, Pieter Sonneveld, Sonja Zweegman, Jurjen Versluis, Jan J. Cornelissen.

https://doi.org/10.3324/haematol.2025.288675

Real-world safety and tolerability of rapid infusion obinutuzumab in chronic lymphocytic leukemia, small lymphocytic lymphoma and non-Hodgkin lymphoma: a provincial review (869 Online Views)

Harshal Senthil, Scott Streilein, Theresa Whiteside, Leonard Minuk, Ivan Landego, Rami Kotb, Chantalle Menard, Roopesh Kansara, Catherine J. Moltzan, James B. Johnston, Pamela Skrabek, Lin Yang, Marc Geirnaert, Versha Banerji

https://doi.org/10.3324/haematol.2025.288780

Case Reports

3

Complete remission of bronchus-associated lymphoid tissue lymphoma after antibiotic treatment for Tropheryma whipplei (337 Online Views)

Teresa Antonia Kiener, Gregor Schweighofer-Zwink, Gundula Rendl, Jan Marco Kern, Lenka Baskova, Daniel Neureiter, Thomas Melchardt, Markus Raderer, Richard Greil, Christian Pirich

https://doi.org/10.3324/haematol.2025.288045

Granuloma annulare-like pseudohistiocytosis: a specific manifestation of ETV6::SYK-rearranged myeloid neoplasm with eosinophilia (365 Online Views)

Giorgio Alberto Croci, Daniele Cattaneo, Silvia Tabano, Ilaria Catusi, Manuela Zappa, Carlo Alberto Maronese, Niccolo Bolli, Angelo Valerio Marzano, Alessandra Iurlo

https://doi.org/10.3324/haematol.2025.288536

Acute myeloid leukemia with t(10;17)(p15;q21)/ ZMYND11::MBTD1: a subtype with minimal differentiation, CD7/CD56 expression, and generally poor outcomes in adults (598 Online Views)

Qing Wei, Naveen Pemmaraju, Sa A. Wang, Shimin Hu, Courtney DiNardo, Ghayas C. Issa, Carlos E. Bueso-Ramos, Jie Xu, Shaoying Li, Jeffrey L. Medeiros, Guilin Tang

https://doi.org/10.3324/haematol.2025.288752

Erratum

1

Erratum to: “Lower incidence of chronic graft-versus-host disease after ruxolitinib plus extracorporeal photopheresis versus ruxolitinib alone in steroid-refractory acute graft-versus-host disease following allogeneic stem cell transplantation” (2 Online Views)

Iryna Lastovytska, Silke Heidenreich, Evgeny Klyuchnikov, Christian Niederwieser, Nico Gagelmann, Johanna Richter, Radwan Massoud, Kristin Rathje, Tetiana Perekhrestenko, Gaby Zeck, Catherina Lück, Dietlinde Janson, Christine Wolschke, Francis Ayuk, Nicolaus Kröger

https://doi.org/10.3324/haematol.2025.289363