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April, 2024
No. 109 (4)

Landmark papers in Hematology

Anti-CD19 chimeric antigen receptor T-cell therapy for B-cell acute lymphoid leukemia (568 Online Views)

Aaron P. Rapoport

https://doi.org/10.3324/haematol.2024.285155

Editorials

Eligibility criteria: too big, too small or just right? (467 Online Views)

Ehab Atallah

https://doi.org/10.3324/haematol.2023.283972

Use, variability, and justification of eligibility criteria for phase II and III clinical trials in acute leukemia

Andrew Hantel et al.

More than a lonca-shot: beating the odds in relapsed/ refractory diffuse large B-cell lymphoma (549 Online Views)

Carrie Ho, Stephen D. Smith

https://doi.org/10.3324/haematol.2023.284056

Loncastuximab tesirine in relapsed/refractory diffuse large B-cell lymphoma: long-term efficacy and safety from the phase II LOTIS-2 study

Paolo F. Caimi et al.

Using machine learning to unravel the intricacy of acute myeloid leukemia (553 Online Views)

Luca Guarnera, Valeria Visconte

https://doi.org/10.3324/haematol.2023.284085

Prognostic value of European LeukemiaNet 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia

Silvia Park et al.

MYC overexpression: adding another piece to the puzzle of high-risk mantle cell lymphoma (947 Online Views)

Anita Kumar

https://doi.org/10.3324/haematol.2023.284105

MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53 – a Nordic Lymphoma Group study

Joana M. Rodrigues et al.

First-line MAPK inhibition in pediatric histiocytosis: are we ready? (456 Online Views)

Oussama Abla

https://doi.org/10.3324/haematol.2023.284188

Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders

Eily Cournoyer et al.

A key to engineering natural killer cells to attack acute myeloid leukemia (533 Online Views)

Yosuke Masamoto, Mineo Kurokawa

https://doi.org/10.3324/haematol.2023.284272

Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for natural killer-cell therapy in acute myeloid leukemia

Yuta Kaito et al.

Review Articles

How we manage a high D-dimer (3250 Online Views)

Massimo Franchini, Daniele Focosi, Mario Piergiulio Pezzo, Pier Mannuccio Mannucci

https://doi.org/10.3324/haematol.2023.283966

Articles

Acute Leukemia

Use, variability, and justification of eligibility criteria for phase II and III clinical trials in acute leukemia (892 Online Views)

Andrew Hantel, Marlise R. Luskin, Irum Khan, Elizabeth Warner, Anand A. Patel, Thomas P. Walsh, Daniel J. DeAngelo, Christopher S. Lathan, Gregory A. Abel

https://doi.org/10.3324/haematol.2023.283723
Acute Lymphoblastic Leukemia

Association of NUDT15 gene polymorphism with adverse reaction, treatment efficacy, and dose of 6-mercaptopurine in patients with acute lymphoblastic leukemia: a systematic review and meta-analysis (774 Online Views)

Shan Du, Xuefei Huang, Xia He, Mian Mao, Min Chen, Rong Zhang, Huikai Shao, Ziyan Lv, Xinxia Liu, Junlan Chuan

https://doi.org/10.3324/haematol.2023.282761

Susceptibility of pediatric acute lymphoblastic leukemia to STAT3 inhibition depends on p53 induction (1253 Online Views)

Luca Gasparoli, Clemence Virely, Alexia Tsakaneli, Noelia Che, Darren Edwards, Jack Bartram, Michael Hubank, Deepali Pal, Olaf Heidenreich, Joost H.A. Martens, Jasper de Boer, Owen Williams

https://doi.org/10.3324/haematol.2023.283613
Acute Myeloid Leukemia

Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase (1064 Online Views)

Danny V. Jeyaraju, Maryam Alapa, Ann Polonskaia, Alberto Risueño, Prakash Subramanyam, Amit Anand, Kaushik Ghosh, Charalampos Kyriakopoulos, Daiane Hemerich, Rose Hurren, Xiaoming Wang, Marcela Gronda, Aarif Ahsan, Hsiling Chiu, Geethu Thomas, Evan F. Lind, Daniel L Menezes, Aaron D. Schimmer, Patrick R. Hagner, Anita Gandhi, Anjan G. Thakurta

https://doi.org/10.3324/haematol.2023.283437

Prognostic value of European LeukemiaNet 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia (1386 Online Views)

Silvia Park, Tong Yoon Kim, Byung-Sik Cho, Daehun Kwag, Jong-Mi Lee, MyungShin Kim, Yonggoo Kim, Jamin Koo, Anjali Raman, Tae Kon Kim, Hee-Je Kim

https://doi.org/10.3324/haematol.2023.283606

Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for natural killer-cell therapy in acute myeloid leukemia (1409 Online Views)

Yuta Kaito, Emi Sugimoto, Fumi Nakamura, Yutaka Tsukune, Makoto Sasaki, Shunsuke Yui, Hiroki Yamaguchi, Susumu Goyama, Yasuhito Nannya, Kinuko Mitani, Hideto Tamura, Yoichi Imai

https://doi.org/10.3324/haematol.2023.282915
Cell Therapy & Immunotherapy

HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation (745 Online Views)

Carlotta Welters, Marthe-Lina Welters, Serena Stadler, Lars Bullinger, Julian Strobel, Holger Hackstein, Arunraj Dhamodaran, Thomas Blankenstein, Leo Hansmann

https://doi.org/10.3324/haematol.2023.283812
Hemostasis

Tissue factor pathway inhibitor is associated with risk of venous thromboembolism and all-cause mortality in patients with cancer (788 Online Views)

Cornelia Englisch, Florian Moik, Johannes Thaler, Silvia Koder, Nigel Mackman, Matthias Preusser, Ingrid Pabinger, Cihan Ay

https://doi.org/10.3324/haematol.2023.283581
Histiocytic Disorder

Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders (1774 Online Views)

Eily Cournoyer, Justin Ferrell, Susan Sharp, Anish Ray, Michael Jordan, Christopher Dandoy, Michael Grimley, Somak Roy, Robert Lorsbach, Arnold C. Merrow, Adam Nelson, Allison Bartlett, Jennifer Picarsic, Ashish Kumar

https://doi.org/10.3324/haematol.2023.283295
Non-Hodgkin Lymphoma

Immunochemotherapy plus lenalidomide for high-risk mantle cell lymphoma with measurable residual disease evaluation (1234 Online Views)

Zachary D. Epstein-Peterson, Esther Drill, Umut Aypar, Connie Lee Batlevi, Philip Caron, Ahmet Dogan, Pamela Drullinsky, John Gerecitano, Paul A. Hamlin, Caleb Ho, Allison Jacob, Ashlee Joseph, Leana Laraque, Matthew J. Matasar, Alison J. Moskowitz, Craig H. Moskowitz, Chelsea Mullins, Colette Owens, Gilles Salles, Heiko Schöder, David J. Straus, Anas Younes, Andrew D. Zelenetz, Anita Kumar

https://doi.org/10.3324/haematol.2023.282898

Outcome of combined modality treatment in first-line for stage I(E) peripheral T-cell lymphoma; a nationwide population-based cohort study from the Netherlands (1222 Online Views)

Frederik O. Meeuwes, Mirian Brink, Wouter Plattel, Marjolein W.M. van der Poel, Marie José Kersten, Mariëlle Wondergem, Lara Böhmer, F.J. Sherida H. Woei-A-Jin, Otto Visser, Rimke Oostvogels, Patty M. Jansen, Karen J. Neelis, Anne P.G. Crijns, Laurien A. Daniëls, Tjeerd J.F. Snijders, Joost S.P. Vermaat, Gerwin A. Huls, Marcel Nijland

https://doi.org/10.3324/haematol.2023.283174

MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53 – a Nordic Lymphoma Group study (1100 Online Views)

Joana M. Rodrigues, Peter Hollander, Lina Schmidt, Eirinaios Gkika, Masoud Razmara, Darshan Kumar, Christian Geisler, Kirsten Grønbæk, Christian W. Eskelund, Riikka Räty, Arne Kolstad, Christer Sundström, Ingrid Glimelius, Anna Porwit, Mats Jerkeman, Sara Ek

https://doi.org/10.3324/haematol.2023.283352

Loncastuximab tesirine in relapsed/refractory diffuse large B-cell lymphoma: long-term efficacy and safety from the phase II LOTIS-2 study (2674 Online Views)

Paolo F. Caimi, Weiyun Z. Ai, Juan Pablo Alderuccio, Kirit M. Ardeshna, Mehdi Hamadani, Brian Hess, Brad S. Kahl, John Radford, Melhem Solh, Anastasios Stathis, Pier Luigi Zinzani, Ying Wang, Yajuan Qin, Luqiang Wang, Zhiying Cindy Xu, Carmelo Carlo-Stella

https://doi.org/10.3324/haematol.2023.283459

Polatuzumab vedotin plus bendamustine and rituximab or obinutuzumab in relapsed/refractory follicular lymphoma: a phase Ib/II study (1740 Online Views)

Christopher R. Flowers, Matthew J. Matasar, Alex F. Herrera, Mark Hertzberg, Sarit Assouline, Judit Demeter, Andrew McMillan, Amitkumar Mehta, Stephen Opat, Marek Trnňný, Lisa Musick, Jamie Hirata, Annie Yang, Laurie H. Sehn

https://doi.org/10.3324/haematol.2023.283557
Plasma Cell Disorders

Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma (1193 Online Views)

Gege Chen, Xuejie Gao, Xinyan Jia, Yingcong Wang, Li Xu, Dandan Yu, Shuaikang Chang, Hui Deng, Ke Hu, Guanli Wang, Bo Li, Zhijian Xu, Yumeng Lu, Huaping Wang, Ting Zhang, Dongliang Song, Guang Yang, Xiaosong Wu, Huabin Zhu, Weiliang Zhu, Jumei Shi

https://doi.org/10.3324/haematol.2023.282789

Single-cell analysis of the CD8+ T-cell compartment in multiple myeloma reveals disease specific changes are chiefly restricted to a CD69- subset suggesting potent cytotoxic effectors exist within the tumor bed (890 Online Views)

James Favaloro, Christian E. Bryant, Edward Abadir, Samuel Gardiner, Shihong Yang, Tracy King, Najah Nassif, Lisa M. Sedger, Richard Boyle, Douglas E. Joshua, P. Joy Ho

https://doi.org/10.3324/haematol.2023.283062
Stem Cell Transplantation

Targeting TFH cells is a novel approach for donor-specific antibody desensitization of allograft candidates: an in vitro and in vivo study (766 Online Views)

Ning Ma, Wei-Bing Wu, Xiang-Yu Zhao, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Xiao-Dong Mo, Yuan-Yuan Zhang, Xiao-Su Zhao, Yu-Qian Sun, Yi-Fei Cheng, Kai-Yan Liu, Ying-Jun Chang, Xiao-Jun Huang

https://doi.org/10.3324/haematol.2023.283698

Letters to the Editor

Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients (1052 Online Views)

Mayumi Hangai, Takahisa Kawaguchi, Masatoshi Takagi, Keitaro Matsuo, Soyoung Jeon, Charleston W.K. Chiang, Andrew T. Dewan, Adam J. de Smith, Toshihiko Imamura, Yasuhiro Okamoto, Akiko M. Saito, Takao Deguchi, Michiaki Kubo, Yoichi Tanaka, Yoko Ayukawa, Toshinari Hori, Kentaro Ohki, Nobutaka Kiyokawa, Takeshi Inukai, Yuki Arakawa, Makiko Mori, Daisuke Hasegawa, Daisuke Tomizawa, Hiroko Fukushima, Yuki Yuza, Yasushi Noguchi, Yuichi Taneyama, Setsuo Ota, Hiroaki Goto, Masakatsu Yanagimachi, Dai Keino, Kazutoshi Koike, Daisuke Toyama, Yozo Nakazawa, Kozue Nakamura, Koichi Moriwaki, Yujin Sekinaka, Daisuke Morita, Shinsuke Hirabayashi, Yosuke Hosoya, Yuri Yoshimoto, Hiroki Yoshihara, Miwa Ozawa, Shinobu Kobayashi, Naho Morisaki, Tshewang Gyeltshen, Osamu Takahashi, Yukinori Okada, Makiko Matsuda, Toshihiro Tanaka, Johji Inazawa, Junko Takita, Yasushi Ishida, Akira Ohara, Catherine Metayer, Joseph L. Wiemels, Xiaomei Ma, Shuki Mizutani, Katsuyoshi Koh, Yukihide Momozawa, Keizo Horibe, Fumihiko Matsuda, Motohiro Kato, Atsushi Manabe, Kevin Y. Urayama

https://doi.org/10.3324/haematol.2023.282914

BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics (1192 Online Views)

Rongqing Aaron Pan, Youzhen Wang, Shumei Qiu, Mariana Villalobos-Ortiz, Jeremy Ryan, Erick Morris, Ensar Halilovic, Anthony Letai

https://doi.org/10.3324/haematol.2023.283060

Subcutaneous injection of IHP-102 prevents lung vaso-occlusion in sickle cell disease mice (729 Online Views)

Rikesh K. Dubey, Ravi Vats, Tomasz Brzoska, Tomasz W. Kaminski, Omika Katoch, Jesus Tejero, Gabriel Njikang, John Paderi, Prithu Sundd

https://doi.org/10.3324/haematol.2023.283716

Long-term outcome after autologous BCR::ABL1-negative peripheral blood stem cell transplantation in adults with Philadelphia-positive acute lymphoblastic leukemia: a comparative study (541 Online Views)

Leo Caillot, Mathieu Leclerc, Emmanuel Jacques Raphael Sleiman, Ivan Sloma, Orianne Wagner-Ballon, Alexis Claudel, Florence Beckerich, Rabah Redjoul, Christine Robin, Vincent Parinet, Cecile Pautas, Dehbia Menouche, Selwa Bouledroua, Ludovic Cabanne, Yakout Nait-Sidenas, Eric Gautier, Helene Rouard, Ingrid Lafon, Yves Chalandon, Nicolas Boissel, Denis Caillot, Sebastien Maury

https://doi.org/10.3324/haematol.2023.283742

Glofitamab monotherapy induces high complete response rates and manageable safety in Chinese patients with heavily pretreated relapsed or refractory diffuse large B-cell lymphoma (1414 Online Views)

Yu-Qin Song, Hui-Lai Zhang, Hui-Qiang Huang, Qing-Yuan Zhang, Hong-Mei Jing, Chao Wang, Chun Wu, Dong-Hang Li, Yu Dai, Kathryn Humphrey, Jun Zhu

https://doi.org/10.3324/haematol.2023.283802

Low-dose azacitidine, pioglitazone and all-trans retinoic acid is safe in patients aged ≥60 years with acute myeloid leukemia refractory to standard induction chemotherapy (AMLSG 26-16/AML-ViVA): results of the safety run-in phase (1079 Online Views)

Daniel Heudobler, Florian Luke, Joachim Hahn, Matthias Grube, Pavla Schlosser, Stephan Kremers, Thomas Sudhoff, Jorg Westermann, Marie Luise Hutter-Kronke, Richard F. Schlenk, Daniela Weber, Peter Paschka, Florian Zeman, Hartmut Dohner, Wolfgang Herr, Albrecht Reichle, Simone Thomas

https://doi.org/10.3324/haematol.2023.283864

Comorbidity indices for prognostic evaluation in multiple myeloma: a comprehensive evaluation of the Revised Myeloma Comorbidity Index and other comorbidity indices with pro- and retrospective applications (469 Online Views)

Katja Schoeller, Gabriele Ihorst, Heike Reinhardt, Maximilian Holler, Sophia Scheubeck, Georg Herget, Ralph Wäsch, Monika Engelhardt

https://doi.org/10.3324/haematol.2023.283884

Catheter-related thrombosis in stem cell recipients: comparison of different types of catheter (615 Online Views)

Slawomir Milczarek, Piotr Kulig, Oliwia Piotrowska, Alina Zuchmanska, Anna Bielikowicz, Bogusław Machalinski

https://doi.org/10.3324/haematol.2023.283924

Small myeloid subclones are present at diagnosis of multiple myeloma in patients who develop secondary myelodysplastic syndromes (595 Online Views)

Guillaume Escure, Elise Fournier, Cynthia Saade, Lama Hasan Bou Issa, Inès Arib, Rémi Tilmont, Nicolas Gazeau, Binta M. Thiam, Morgane Chovet, Maxime Delforge, Nicolas Gower, Léa Fléchon, Doriane Cavalieri, Paul Chauvet, Morgane Nudel, Laure Goursaud, Céline Berthon, Bruno Quesnel, Thierry Facon, Claude Preudhomme, Nicolas Duployez, Salomon Manier

https://doi.org/10.3324/haematol.2023.284050

Factor VIII genotype and the risk of developing highresponding or low-responding inhibitors in severe hemophilia A: data from the PedNet Hemophilia Cohort of 1,202 children (645 Online Views)

Nadine G. Andersson, Veerle Labarque, Mutlu Kartal-Kaess, Fernando Pinto, Torben Stamm Mikkelsen, Rolf Ljung, PedNet Study Group

https://doi.org/10.3324/haematol.2023.284095

CD38 expression by plasma cells in extramedullary multiple myeloma (774 Online Views)

Laura Notarfranchi, Fabrizio Accardi, Cristina Mancini, Eugenia Martella, Sabrina Bonomini, Roberta Segreto, Rosanna Vescovini, Anna Benedetta Dalla Palma, Gabriella Sammarelli, Giannalisa Todaro, Paola Storti, Jessica Burroughs-Garcia, Nicolas Thomas Iannozzi, Vincenzo Raimondi, Oxana Lungu, Stefania Ricci, Luisa Craviotto, Nicola Giuliani

https://doi.org/10.3324/haematol.2023.284169

Case Reports

A patient with minimal myeloma treatment who survived for 20 years (1478 Online Views)

Alenka Djarmila Behsen, Esten Nymoen Vandsemb, Tobias Schmidt Slørdahl, Henrik Hjorth-Hansen, Petter Quist-Paulsen, Kristine Misund, Anne-Marit Sponaas, Anders Waage

https://doi.org/10.3324/haematol.2023.283563

Emergence of TP53 mutation during lenalidomide therapy of myelodysplastic syndrome with del(5q) and its subsequent disappearance following salvage therapy with decitabine (716 Online Views)

Naseema Gangat, Naresh Bellam, Kaaren Reichard, Ayalew Tefferi

https://doi.org/10.3324/haematol.2023.284547

Erratum

Erratum to: Retrospective analysis of pacritinib in patients with myelofibrosis and severe thrombocytopenia (276 Online Views)

Srdan Verstovsek, Ruben Mesa, Moshe Talpaz, Jean-Jacques Kiladjian, Claire N. Harrison, Stephen T. Oh, Alessandro M. Vannucchi, Raajit Rampal, Bart L. Scott, Sarah A. Buckley, Adam R. Craig, Karisse Roman-Torres, John O. Mascarenhas

https://doi.org/10.3324/haematol.2023.284815

Erratum to: Utility of clinical comprehensive genomic characterization for diagnostic categorization in patients presenting with hypocellular bone marrow failure syndromes (184 Online Views)

Piers Blombery, Lucy Fox, Georgina L. Ryland, Ella R. Thompson, Jennifer Lickiss, Michelle McBean, Satwica Yerneni, Alison Trainer, David Hughes, Anthea Greenway, Francoise Mechinaud, Erica M. Wood, Graham J. Lieschke, Jeff Szer, Pasquale Barbaro, John Roy, Joel Wight, Elly Lynch, Melissa Martyn, Clara Gaff, David Ritchie

https://doi.org/10.3324/haematol.2023.284760
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