Vol. 111 No. 2 (2026): February, 2026

Kellen B. Gil, Jamie Borg, Rosana Moreira Pereira, Anagha Inguva-Sheth, Geovana Araujo, Jeremy Rahkola, William Showers, Abby Grier, Angelo D’Alessandro, Clayton Smith, Christine McMahon, Daniel A. Pollyea, Austin E. Gillen, Maria L. Amaya

https://doi.org/10.3324/haematol.2025.287352

C-C motif chemokine receptor-like 2 promotes the interferon-γ signaling response in myeloid neoplasms with erythroid differentiation and mutated TP53 (1600 Online Views)

Nour Sabiha Naji, Sergiu Pasca, Theodora Chatzilygeroudi, Pablo Toledano-Sanz, Joseph Rimando, Yuju An, Yashvi Hemani, Brandy Perkins, Xinghan Zeng, Conover Talbot Jr., Bogdan Paun, Abdulmuez Abdulmalik, Chen Lossos, Tatianna R. Boronina, Ilias Sinanidis, Panagiotis Tsakiroglou, Priyanka Fernandes, Christopher Esteb, Alexander J. Ambinder, Robert N. Cole, Rena Xian, Ivana Gojo, Suman Paul, Mark J. Levis, Amy E. DeZern, Leo Luznik, Styliani Karanika, Linda S. Resar, Richard J. Jones, Frederick Bunz, Lukasz Gondek, Marios Arvanitis, Theodoros Karantanos

https://doi.org/10.3324/haematol.2025.287740

Genetic risk classification in acute myeloid leukemia patients treated with hematopoietic cell transplantation and post-transplant cyclophosphamide (1072 Online Views)

Marta Villalba, Juan Montoro, Aitana Balaguer-Roselló, Pedro Chorão, Pedro Asensi Cantó, Pablo Granados, Inés Gómez-Seguí, Pilar Solves, Esperanza Such, José Cervera, Eva Barrragán, Marta Santiago, José V. Gil-Ortí, Brais Lamas, Ana Bataller, Alberto Louro, Javier de la Rubia, Miguel Á. Sanz, Jaime Sanz

https://doi.org/10.3324/haematol.2025.287860

Strategies for identifying NUP98 rearrangements in adult myeloid neoplasms (1817 Online Views)

Lisa D. Yuen, Robert P. Hasserjian, Amir T. Fathi, Marlise R. Luskin, Eric S. Winer, Paola Dal Cin, Annette S. Kim, R. Coleman Lindsley, Harrison K. Tsai, Valentina Nardi

https://doi.org/10.3324/haematol.2025.288080

Anti-HLA class I IgG subclasses skew platelet activation mechanisms in transfusion refractoriness (721 Online Views)

Adèle Couvidou, Mathieu Wald, Catherine Angénieux, Juliana Pires-Marafon, Marie-Joëlle Apithy, Catherine Humbrecht, Luc-Matthieu Fornecker, Nicolas Congy-Jolivet, Arnaud Dupuis, Jérôme Rollin, Blandine Maître

https://doi.org/10.3324/haematol.2025.287677

Post-transplant cyclophosphamide improves survival compared to antithymocyte globulin in HLA-mismatched unrelated donor stem cell transplantation (1105 Online Views)

Jonathan Bordat, Eleonore Kaphan, Marie Robin, Alienor Xhaard, Flore Sicre de Fontbrune, Florian Chevillon, Gerard Socie, Regis Peffault de Latour, David Michonneau

https://doi.org/10.3324/haematol.2024.287157

Changing donors improves outcomes of second transplantation in patients who experienced graft failure after first allogeneic stem cell transplantation (1903 Online Views)

Rui Ma, Xiao-Yu Zhu, Yue Lu, Jia Chen, Li Xuan, Hai-Long Yuan, Yang Cao, Wei-Jie Cao, Xiao-Sheng Fang, Kou-Rong Miao, Xiao-Xia Hu, Hai Yi, Yan-Min Zhao, Yuan-Bin Wu, Ting Yang, Hong-Tao Wang, Yue Yin, Zhong-Ming Zhang, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Kai-Yan Liu, Xiao-Jun Huang, Yu-Qian Sun

https://doi.org/10.3324/haematol.2025.287554

IGLV3-21^R110-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia (1642 Online Views)

Claudia Fischer, Shih-Shih Chen, Johanna Nimmerfroh, Anne Eugster, Simon Stücheli, Christoph Schultheiß, Corinne Widmer, Dominik Heim, Benjamin Kasenda, Jakob Passweg, Sebastian Kobold, Lukas Egli, Nicolò Coianiz, Obinna Chijioke, Nicholas Chiorazzi, Marie Follo, Heinz Läubli, Matthias Peipp, Mascha Binder

https://doi.org/10.3324/haematol.2025.287697

Early cytokine and chemokine signals shape the anti-AML activity of bispecific engager-secreting T cells (915 Online Views)

Natalie J. Holl, Adam Fearnow, Ilias Christodoulou, Stamatia C. Vorri, Ruyan Rahnama, Jun Choe, Alokesh Ghosal, Weng-Ian Ng, Vinay Vyas, Hannah W. Song, Ravi Varadhan, Challice L. Bonifant

https://doi.org/10.3324/haematol.2025.287934

Improving chronic myeloid leukemia management and quality of life: patient and physician survey on unmet needs from the CML SUN survey (3040 Online Views)

Fabian Lang, Zack Pemberton-Whiteley, Joannie Clements, Cristina Ruiz, Delphine Rea, Lisa Machado, Naoto Takahashi, Sung-Ho Moon, Andrew Grigg, Cornelia Borowczak, Peter Schuld, Pauline Frank, Cristina Constantinescu, Carla Boquimpani, Jorge E. Cortes

https://doi.org/10.3324/haematol.2025.287772

Genetic determinants of clinical variability in type 2 von Willebrand disease: bridging genotype and phenotype (1874 Online Views)

Omid Seidizadeh, Alessandro Ciavarella, Luciano Baronciani, Paola Colpani, Andrea Cairo, Simona Maria Siboni, Flora Peyvandi

https://doi.org/10.3324/haematol.2025.288342

Dental plaque microbiota following allogeneic hematopoietic cell transplantation and risk of chronic graft-versus-host disease (938 Online Views)

Hakan Gem, Maryam Ebadi, Gale Sebastian, Rania Abasaeed, Michele Lloid, Samuel S. Minot, David R. Dean, Armin Rashidi

https://doi.org/10.3324/haematol.2025.288279

Comparative single-cell lineage bias in human and murine hematopoietic stem cells (1731 Online Views)

Isaac Shamie, Meghan Bliss-Moreau, Jamie Casey Lee, Ronald Mathieu, Harold M. Hoffman, Bob Geng, Nathan E. Lewis, Yanfang Peipei Zhu, Ben A. Croker

https://doi.org/10.3324/haematol.2025.287897

Recombinant human erythropoietin plus all-trans retinoic acid and testosterone undecanoate for the treatment of anemia in patients with lower-risk myelodysplastic syndromes: a multicenter, single-arm, prospective trial (1886 Online Views)

Chen Mei, Gaixiang Xu, Cuiping Zheng, Yaping Xie, Minming Li, Yanping Shao, Rongxin Yao, Shi Tao, Wei Jiang, Jun Guo, Zhiyin Zheng, Wei Wang, Xinping Zhou, Liya Ma, Li Ye, Yingwan Luo, Chunmei Yang, Wenjuan Yu, Wanzhuo Xie, Jie Jin, Hongyan Tong

https://doi.org/10.3324/haematol.2024.287055

Infection risk in 158 patients with relapsed/refractory multiple myeloma treated with bispecific antibodies: a single-center experience (2325 Online Views)

Lorenzo Cani, Sara A. Scott, Danielle Roberts, Nisha S. Joseph, Craig C. Hofmeister, Vikas A. Gupta, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Jonathan L. Kaufman

https://doi.org/10.3324/haematol.2025.288187

Belantamab mafodotin does not induce B-cell maturation antigen loss or systemic immune dysfunction in multiple myeloma (3366 Online Views)

Hanny Musa, Michał Mielnik, Suzanne Trudel, Katja Weisel, Taryn Mockus-Daehn, Geraldine Ferron-Brady, Qingqing Hong, Yinjiao Ma, Sagar Patel, Sunil Suchindran, Xiangdong Zhou, Paul G. Richardson, Adam D. Cohen, Daniel E. Lowther

https://doi.org/10.3324/haematol.2025.288203

The glutaminase activity of ASNS fuels glutamine metabolism in leukemia (734 Online Views)

Wai-Kin Chan, Lin Tan, Sara A. Martinez, Di Du, Thomas D. Horvath, Michael Pontikos, Leona A. Rusling, Yulun Chiu, Bao Q. Tran, Susan B. Rempe, Sergei Sukharev, John N. Weinstein, Philip L. Lorenzi

https://doi.org/10.3324/haematol.2024.287099

Genomic ancestry, F8 variants, and immune tolerance in hemophilia A patients with inhibitors: exome sequencing insights (1781 Online Views)

Hanaisa Sant’Anna, Rafael Tou, Lucas Faria-Costa, Julia Duarte, Bruno Miwa, Renan Pedra de Souza, Ricardo Mesquita Camelo, Daniel Gonçalves Chaves, Claudia Santos Lorenzato, Tânia Hissa Anegawa, Andrea Gonçalves de Oliveira, Clarissa Barros Ferreira, Luany Elvira Mesquita Carvalho, Vivian Karla Brognoli Franco, Monica Hermida Cerqueira, Maria do Rosário Ferraz Roberti, Fabia Michelle Rodrigues de Araujo Callado, Leina Yukari Etto, Maria Aline Ferreira de Cerqueira, Ieda Solange de Souza Pinto, Andrea Aparecida Garcia, Doralice Marvulle Tan, Daniele Campos Fontes Neves, Maíse Moreira Dias, Luciana Werneck Zuccherato, Eduardo Tarazona-Santos, Suely Meireles Rezende

https://doi.org/10.3324/haematol.2024.287232

Use of upfront autologous stem cell transplantation in myeloma patients aged >65 years: a population-based study by the Nordic Myeloma Study Group (920 Online Views)

Kari Lenita Falck Moore, Samundur Rognvaldsson, Agoston G. Szabo, Vilmantė Vaitekėnaitė, Diana Loigom, Anna Genell, Jonathan Thorsen, Jakob N. Norgaard, Sigrun Thorsteinsdottir, Dorota Knut-Bojanowska, Anna Lysen, Fredrik Schjesvold, Valdas Peceliunas, Ain Kaare, Katrin Palk, Maris Parnat, Alexander Sigurdsson, Annette J. Vangsted, Cecilie H. Blimark; Nordic Myeloma Study Group (Collaborative Group)

https://doi.org/10.3324/haematol.2025.287344

Variables influencing the in vitro measurement of spontaneous aggregation of human platelets (1339 Online Views)

Claudia Ghali, Antonella Fioretti, Mariangela Scavone, Elena Bossi, Bianca Clerici, Simone Birocchi, Evgeny Popov, Marco Centola, Gianmarco Podda, Marco Cattaneo

https://doi.org/10.3324/haematol.2025.287601

Racial differences in the proportion of myeloma cases attributable to excess body weight and diabetes mellitus in the United States (1586 Online Views)

Aishwarya Anuraj, Divya Rath, Andriy Derkach, Saad Z. Usmani, Urvi A. Shah

https://doi.org/10.3324/haematol.2025.287724

Structural and functional insights into γ-glutamyl carboxylase-factor IX interaction: implications for vitamin K-dependent bleeding disorders (1403 Online Views)

Kang Liu, Shixin Li, Guomin Shen, Jiangbo Tong, Nan Jiang, Minwen Hong, Yi Gu, Luju Chen, Yuan Zhao, Jinlin Huang, Jian-Ke Tie, Zhenyu Hao

https://doi.org/10.3324/haematol.2025.287736

The invisible divide: the impact of racial and geographic disparities on multiple myeloma outcomes - insights from a single-site study (693 Online Views)

Michael A. Bauer, Phillip Farmer, Joseph L. Su, Mario Schootman, Chenghui Li, Frits Van Rhee, Samer Al Hadidi, Carolina Schinke, John D. Shaughnessy, Fenghuang Zhan, Cody Ashby

https://doi.org/10.3324/haematol.2025.287760

Serial next-generation sequencing for detecting germline predisposition in acute myeloid leukemia (1807 Online Views)

Jae-Sook Ahn, Joo Heon Park, ChangSun Lee, Ik-Chan Song, Mi Yeon Kim, Sang Kyun Sohn, Ho-Young Yhim, Yong Park, Inho Kim, Ho-Jin Shin, Seong-Kyu Park, Sung-Hyun Kim, June-Won Cheong, Ho Sup Lee, Hyewon Lee, Sung Hwa Bae, Yunsuk Choi, Hong-Ghi Lee, Young Rok Do, Jae Joon Han, Min Kyoung Kim, Silvia Park, Hee-Je Kim, Hyeoung-Joon Kim; Korean AML/MDS Working party (Collaborative Group)

https://doi.org/10.3324/haematol.2025.287794

A novel p.C1130S mutation in a Finnish family with a complex phenotype of von Willebrand disease (883 Online Views)

Bas Calcoen, Irina Portier, Inge Pareyn, Aline Vandenbulcke, Anna-Elina Lehtinen, Riitta Lassila, Claudia Tersteeg, Karen Vanhoorelbeke, Simon F. De Meyer, Timea Szanto

https://doi.org/10.3324/haematol.2025.287900

Assessing the benefit of incorporating an anti-CD38 monoclonal antibody into second- or third-line systemic treatment for patients with relapsed/refractory multiple myeloma: results from the French real-world EMMY study (1111 Online Views)

Thomas Chalopin, Cyrille Hulin, Bruno Royer, Jean-Noel Bastie, Arthur Bobin, Karim Belhadj Merzoug, Margaret Macro, Lionel Karlin, Caroline Jacquet, Mohamad Mohty, Laurent Frenzel, Cécile Sonntag, Jean Fontan, Sophie Rigaudeau, Murielle Roussel, Laurence Sanhes, Driss Chaoui, Laure Vincent, Hubert Orfeuvre, Malek Bouketouche, Ronan Garlantezec, Olivier Decaux, Aurore Perrot

https://doi.org/10.3324/haematol.2025.287954

Benchmarking prophylaxis with factor concentrates: reference data on annualized bleeding rates in children with severe hemophilia (950 Online Views)

Susanna Ranta, Marloes de Kovel, Martin Olivieri, Kathelijn Fischer, Giancarlo Castaman, Christoph Königs, Johannes Oldenburg, Helen Pergantou, Christoph Male, Marijke H. van den Berg

https://doi.org/10.3324/haematol.2025.288101

CXCR2 deficiency with myelokathexis caused by a novel variant: correction via CRISPR/Cas9 (1005 Online Views)

Daniëla M. Hinke, Sofie R. Dorset, Eirik Bratland, Jonas H. Wolff, Astrid M. Olsnes, Jacob Giehm Mikkelsen, Lars Helgeland, Rasmus O. Bak, Andreas Benneche, Trine H. Mogensen

https://doi.org/10.3324/haematol.2025.288111

Safety and efficacy of BCMA CAR-T vs. bispecific antibodies in patients with relapsed multiple myeloma: a systematic review and meta-analysis (2416 Online Views)

Hayley Vandenboom, Othman Akhtar, Aniko Szabo, Ravi Narra, Meera Mohan, Anita D’Souza, Marcelo Pasquini, Binod Dhakal

https://doi.org/10.3324/haematol.2025.288174

The immunophenotypic and genetic characterization of pediatric T-lymphoblastic leukemia with a mature immunophenotype (848 Online Views)

Mahsa Khanlari, Wei Wang, Parastou Tizro, Mohammad K. Eldomery

https://doi.org/10.3324/haematol.2025.288233

Infectious complications in acquired hemophilia A: insights from the Spanish registry (AHASR) (1734 Online Views)

Maria-Eva Mingot-Castellano, Jose Pardos-Gea, Ana Marco Rico, Patricia Alcalde-Mellado, Victoria Salvadores-Alvares, Alicia Jordano Jimenes, Mariana Canaro Hirnyk, Angel Bernardo Gutierrez, Jose Maria Bastida, Jose Agustin Rodriguez Alén, Faustino Garcia Candel, Dolors Tassies Penella, Ana Moreto Quintana, Gala Aglaia Mendez Navarro, Elena Roselló Palmer, Marina Carrasco Expósito, Susana Asenjo Correa, Laura Torres Miñana, Jose Antonio Rodriguez Garcia, Maria Teresa Alvarez-Roman, Rafael Lluch Garcia, Ramon Rodriguez Gonzalez, Jose Manuel Martín Antoran, Nieves Alonso Escobar, Reyes Aguinaco Culebras, Maria Paz Martínez Badás, Shally Marcellini Antonio, Marisol Uribe Barrientos, Nuria Fernández Mosteirin, Monserrat Perez Sanchez, Sandra Valle Herrero, Carlos Cervero Santiago, Isabel-Socorro Caparros Miranda, Miguel Angel Pozas Mañas, Irene Vázquez Fernandez, Cristina Pascual Izquierdo, Sara Caracena Lopez, Pascual Marco Vera

https://doi.org/10.3324/haematol.2025.288480

β-thalassemia trait and iron overload: is it time to consider oral iron chelators? Comment on: “A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies” (827 Online Views)

Alberto Piperno, Raffaella Mariani

https://doi.org/10.3324/haematol.2025.288578

Response to Comment on: “A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with miniphlebotomies” (564 Online Views)

Fabiana Busti, Domenico Girelli

https://doi.org/10.3324/haematol.2025.289073

β-thalassemia trait and iron overload: is it time to consider oral iron chelators? Comment on: “A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies”

Alberto Piperno and Raffaella Mariani

Do high-volume centers really save more lives? A call for scientific rigor and transparency. Comment on: “Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy” (1353 Online Views)

Dries Deeren

https://doi.org/10.3324/haematol.2025.288731

Response to Comment on: “Does size matter? Centerspecific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy” (715 Online Views)

Wolfgang Bethge, Peter Dreger; German Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy e.V. (DAG-HSZT) - German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy (DRST) (Collaborative Group)

https://doi.org/10.3324/haematol.2025.288957