Early view

Apr 24, 2025

Editorials
Letter to the Editor

Review Articles

Asparaginase-associated hyperammonemia (74 Online Views)

Raheel Altaf Raja, Bodil Als-Nielsen, Allan M. Lund, Hendrik Vilstrup, Kim Peder Dalhoff, Kjeld Schmiegelow

https://doi.org/10.3324/haematol.2025.287301

Articles

S-adenosylmethionine addiction confers sensitivity to methionine restriction in KMT2A-rearranged acute lymphoblastic leukemia (120 Online Views)

Trisha Tee, Titine J.J. Ruiter, Shuiyan Wu, Weiya Zhang, Dorette van Ingen Schenau, Maria Rodionova, Danique Wajon, Britt M.T. Vervoort, Kari J.T. Grunewald, Marjolein Bosma, Rico Hagelaar, John Baker-Hernandez, Ahmed Dahaoui, Pauline Schneider, Nanda M. Verhoeven-Duif, Laurens T. van der Meer, Frank N. van Leeuwen

https://doi.org/10.3324/haematol.2023.284869

Production of platelets in vitro in functionalised 3-dimensional scaffolds mimicking the bone marrow niche (64 Online Views)

Holly R. Foster, Maria Colzani, Guenaelle Bouet, Daniel Howard, Christian A. Di Buduo, Nicole Müller-Sienerth, Amie K. Waller, Yi Sun, Natalia Davidenko, Jennifer H. Shepherd, Thomas Moreau, Amanda L. Evans, Paolo M. Soprano, Martin E.M. Parsons, Yumi Ying Sims, Meera Arumugam, Wardiya Afshar-Saber, Ernest Turro, Patricia B. Maguire, Serena M. Best, Ruth E. Cameron, Alessandra Balduini, Gavin J. Wright, Cedric Ghevaert

https://doi.org/10.3324/haematol.2024.286758

Prophylactic and pre-emptive donor lymphocyte infusion in patients with acute myeloid leukemia and myelodysplastic syndrome: validation of current recommendations and proposal of a modified outcome assessment (127 Online Views)

Giuliano Filippini Velázquez, Jan Frederic Weller, Anna Rubeck, Tobias Arndt, Stefan Schiele, Markus Mezger, Claudia Lengerke, Wolfgang Bethge, Martin Trepel, Gernot Müller, Maximilian Christopeit, Christoph Schmid

https://doi.org/10.3324/haematol.2024.287206

A simplified frailty score predicts outcome in curatively treated older patients with classical Hodgkin lymphoma (226 Online Views)

Kjersti Lia, Rasmus Rask Kragh Jørgensen, Per Wikman, Bente L. Wold, Ninja Övergaard, Øystein Fluge, Unn-Merete Fagerli, Hanne Bersvendsen, Idun B. Bø, Sameer Bhargava, Daniel Molin, Alexander Fosså

https://doi.org/10.3324/haematol.2025.287509

Letters to the Editor

Changes in cardiac parameters during venetoclax treatment (44 Online Views)

Roman Brock, Edit Porpaczy, Patrick Caron, Cathrin Skrabs, Renate Thalhammer, Olga Falco, Ingrid Simonitsch-Klupp, Ana-Iris Schiefer, Wolfgang R.Sperr, Karoline V. Gleixner, Martina Schlager, Peter Valent, Raute Sunder-Plassmann, Jutta Bergler-Klein, Katrina Vanura, Chantal Guillemette, Philipp Staber, Ulrich Jäger

https://doi.org/10.3324/haematol.2024.287280

The specific transcriptional profile and clonal selection of monoclonal gammopathy of undetermined significance-like behavior predict an exceptionally favorable prognosis in multiple myeloma (63 Online Views)

Wenqiang Yan, Chen Qiu, Jieqiong Zhou, Jingyu Xu, Jian Cui, Yuntong Liu, Chenxing Du, Tengteng Yu, Shuaishuai Zhang, Weiwei Sui, Shuhui Deng, Yan Xu, Dehui Zou, Weiping Yuan, Lugui Qiu, Mu Hao, Yajing Chu, Gang An

https://doi.org/10.3324/haematol.2025.287523

Apr 17, 2025

Editorials
Article

Lower incidence of chronic graft-versus-host disease after ruxolitinib plus extracorporeal photopheresis versus ruxolitinib alone in steroid-refractory acute graft-versus-host disease following allogeneic stem cell transplantation (1110 Online Views)

Iryna Lastovytska, Silke Heidenreich, Evgeny Klyuchnikov, Christian Niederwieser, Nico Gagelmann, Johanna Richter, Radwan Massoud, Kristin Rathje, Tetiana Perekhrestenko, Gaby Zeck, Catherina Lück, Dietlinde Janson, Christine Wolschke, Francis Ayuk, Nicolaus Kröger

https://doi.org/10.3324/haematol.2024.286824

Articles

Outcomes and treatment patterns in primary and secondary plasma cell leukemia: insights from a large US cohort study (2371 Online Views)

Shagun Singh, Supriya Peshin, Betsy C. Wertheim, Ashley Larsen, Iloabueke Chineke, Douglas W. Sborov, Damian Green, Michaela Liedtke, Marie Okoniewski, Mohammed Wazir, Omar Nadeem, Levanto G. Schachter, Dominique DeGraaff, Victoria A. Vardell, David G. Coffey, Krisstina Gowin

https://doi.org/10.3324/haematol.2024.287158

A phase I / IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis (1457 Online Views)

Pankit Vachhani, Peter Tan, Anne-Marie Watson, Shang-Ju Wu, Ross Baker, Stanley Cheung, Sung-Eun Lee, Chih-Cheng Chen, Tsai-Yun Chen, Hui-Hua Hsiao, Jae Hoon Lee, Lucia Masarova, Shuh Ying Tan, Jana Baskar, Brett Charlton, Alison Findlay, Dieter Hamprecht, Wolfgang Jarolimek, Joanna Leadbetter, John Miller, Kristen Morgan, Amna Zahoor, Gabriela Hobbs

https://doi.org/10.3324/haematol.2024.287231

Prognostic value of minimal residual disease detected by EuroFlow next-generation flow cytometry and next-generation sequencing in patients with multiple myeloma achieving complete response and receiving lenalidomide maintenance after autotransplant: a prospective comparison study (328 Online Views)

Takeshi Yoroidaka, Hiroyuki Takamatsu, Ryota Urushihara, Mitsuhiro Itagaki, Satoshi Yoshihara, Kota Sato, Naoki Takezako, Shuji Ozaki, Kazuhito Suzuki, Kentaro Kohno, Tsuyoshi Muta, Morio Matsumoto, Yasushi Terasaki, Takeshi Yamashita, Shin-ichi Fuchida, Jun Sakamoto, Tadao Ishida, Kenshi Suzuki, Hirokazu Murakami, Brian G.M. Durie, Kazuyuki Shimizu

https://doi.org/10.3324/haematol.2025.287411

Letters to the Editor

Novel PROTAC to target FKBP12: the potential to enhance bone morphogenetic protein activity and apoptosis in multiple myeloma (273 Online Views)

Ingrid Quist-Lokken, Mira Tilseth, Clara Andersson-Rusch, Md Abu Hanif, Michael Walz, Johanna Fredrikke Nordstrand Moen, Megan Anne Vik, Tobias Schmidt Slordahl, Anders Sundan, Felix Hausch, Toril Holien

https://doi.org/10.3324/haematol.2024.287047

A phase II study of ponatinib for prevention of relapse after allotransplantation in FLT3 internal tandem duplication mutation positive (FLT3-ITD+) acute myeloid leukemia: the PONALLO trial (155 Online Views)

Patrice Chevallier, Anne Thiebaut, Sylvie François, Sylvain Chantepie, Marie-Thérèse Rubio, Hélène Labussiere-Wallet, Eolia Brissot, Natacha Maillard, Anne Huynh, Valérie Coiteux, Maxime Jullien, Alice Garnier, Amandine Le Bourgeois, Pierre Peterlin, Thierry Guillaume

https://doi.org/10.3324/haematol.2025.287681

Comments

Apr 10, 2025

Review Series on Acute Leukemia

Articles

Evorpacept plus rituximab for the treatment of relapsed or refractory non-Hodgkin lymphoma: results from the phase I ASPEN-01 study (338 Online Views)

Tae Min Kim, Nehal J. Lakhani, Jacob Soumerai, Manali Kamdar, Justin F. Gainor, Wells Messersmith, Philip Fanning, Shanhong Guan, Feng Jin, Alison Forgie, Hong I. Wan, Jaume Pons, Sophia S. Randolph, Won Seog Kim

https://doi.org/10.3324/haematol.2024.286208

Infections in lower-risk myelodysplastic syndromes - prevalence and risk factors: a report from the European MDS Registry (238 Online Views)

Bente Houtman, Adele Taylor, Corine van Marrewijk, Alexandra Smith, Pierre Fenaux, Catherine Cargo, Argiris Symeonidis, Moshe Mittelman, Reinhard Stauder, Jaroslav Čermák, Guillermo Sanz, Eva Hellström-Lindberg, Luca Malcovati, Lionel Adès, Thibault Comont, Dominic Culligan, Ioannis Kotsianidis, Theo de Witte, Nicole Blijlevens, Saskia Langemeijer, Marlijn Hoeks; EUMDS Consortium (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286880

Reduced incidence of relapse and graft-versus-host disease in acute myeloid leukemia after allogeneic hematopoietic cell transplantation (2426 Online Views)

Haesook T. Kim, Robert J. Soiffer, Corey Cutler, John Koreth, Sarah Nikiforow, Roman M. Shapiro, Amar Kelkar, Mahasweta Gooptu, Rizwan Romee, Catherine J. Wu, Joseph H. Antin, Jerome Ritz, Vincent T. Ho.

https://doi.org/10.3324/haematol.2025.287390

Dynamic change in Epstein-Barr virus DNA predicts prognosis in early stage natural killer/T-cell lymphoma with pegaspargase-based treatment: long-term follow-up and biomarker analysis from the NHL-004 multicenter randomized study (477 Online Views)

Huijuan Zhong, Shu Cheng, Jie Xiong, Jiayi Chen, Rongji Mu, Haoxu Yang, Hongmei Yi, Qi Song, Hao Zhang, Yu Hu, Guohui Cui, Juying Wei, Xi Zhang, Bing Xu, Wenbin Qian, Xiaobing Huang, Ming Hou, Feng Yan, Xin Wang, Yongping Song, Yuanhua Liu, Xuejun Ma, Jianda Hu, Fei Li, Chongyang Wu, Junmin Chen, Li Yu, Ou Bai, Jingyan Xu, Zunmin Zhu, Li Liu, Xin Zhou, Li Huang, Yin Tong, Ting Niu, Depei Wu, Xufeng Jiang, Chaofu Wang, Binshen Ouyang, Gang Cai, Biao Li, Jia Liu, Zhifeng Li, Rong Xiao, Luqun Wang, Yujie Jiang, Yanyan Liu, Xiaoyun Zheng, Pengpeng Xu, Li Wang, Saijuan Chen, Wei-Li Zhao

https://doi.org/10.3324/haematol.2025.287513

Letters to the Editor

Case Reports

Apr 3, 2025

Pro and Con Editorials

Editorials

Review Articles

Articles

Long-term kidney complications in childhood leukemia survivors: a study from the Childhood and Adolescent Leukaemia (LEA) project (221 Online Views)

Carine Domenech, Paul Saultier, Zeinab Hamidou, Marie-Dominique Tabone, Marlène Pasquet, Virginie Gandemer, Stéphane Ducassou, Marilyne Poirée, Dominique Plantaz, Jean-Hugues Dalle, Pascal Chastagner, Sandrine Thouvenin, Justyna Kanold, Alexandre Theron, Isabelle Pellier, Yves Reguerres, André Baruchel, Pascal Auquier, Justine Bacchetta, Gérard Michel, Laurence Derain-Dubourg

https://doi.org/10.3324/haematol.2024.286940

Consistent clinical factor VIII equivalency is unlikely for non-factor therapies in hemophilic mice (445 Online Views)

Thibaud Sefiane, Geneviève McCluskey, Marie Clavel, Hortense Maynadié, Ivan Peyron, Tovo David, Camille Brochier, François Saller, Mariem Khamari, Cécile V. Denis, Olivier D. Christophe, Peter J. Lenting, Vincent Muczynski, Caterina Casari

https://doi.org/10.3324/haematol.2024.286982

Early identification of functional high-risk multiple myeloma patients after transplant: the predictive power of fat fraction and Response Assessment Category score in diffusion-weighted whole-body magnetic resonance imaging (360 Online Views)

Angelo Belotti, Barbara Frittoli, Sofia Terlizzi, Rossella Ribolla, Claudia Crippa, Chiara Saeli, Samantha Ferrari, Nicola Bianchetti, Chiara Bottelli, Chiara Cattaneo, Carmela Carbone, Alessandro Gullino, Marco Chiarini, Viviana Giustini, Aldo Roccaro, Luigi Grazioli, Alessandra Tucci

https://doi.org/10.3324/haematol.2025.287409

Letters to the Editor

Hematologic dysfunction and myeloid neoplasm risk in patients treated with lutetium-177 prostate specific antigen membrane therapy (264 Online Views)

Yael Kusne, Osama M. Mosalem, Jaxon Quillen, Skye Buckner-Petty, Miguel Muniz, Oliver Sartor, Geoffrey B. Johnson, Daniel S. Childs, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2024.286808

A phase IIb study of selinexor in combination with daratumumab in patients with daratumumab-refractory multiple myeloma (447 Online Views)

Noa Biran, Eli Zolotov, David Vesole, Harsh Parmar, Pooja Phull, Kimberley Doucette, Patrick Roney, Jaeil Ahn, Rena Feinman, Joshua Zenreich, Palka Anand, Monique Pace, Alexandra Della Pia, Bianca DeAgresta, Lisa Biamonte, Adolfo Aleman, Ella Rutanen, Aimee Chappell, Susan Kumka, David S. Siegel

https://doi.org/10.3324/haematol.2024.287053

Comments

Mar 27, 2025

Review Articles

Articles

Cytogenetic abnormalities in polycythemia vera: phenotypic correlates and prognostic relevance in 669 informative cases (321 Online Views)

Moazah Iftikhar, Masooma Rana, Yamna Jadoon, Maymona Abdelmagid, Kaaren Reichard, Cinthya Zepeda Mendoza, Animesh Pardanani, Ayalew Tefferi, Naseema Gangat

https://doi.org/10.3324/haematol.2025.287569

Letters to the Editor

Genetic and clinical characteristics of patients with Shwachman Diamond syndrome with special consideration of treatment with granulocyte-colony stimulating factor (294 Online Views)

Sabine Mellor-Heineke, Julia Skokowa, Natali Gerschmann, Ekaterina Deordieva, Ivan Tesakov, Sally Kinsey, Maja Klaudel-Dreszler, Piero Farruggia, Martina Sukova, Mikael Sundin, Yasmine El Chazli, Tania N. Masmas, Leen Willems, Georg Ebetsberger-Dachs, Hans C. Erichsen, Orna Steinberg-Shemer, Anna Shcherbina, Karl Welte, Cornelia Zeidler

https://doi.org/10.3324/haematol.2024.286119

MAPK-kinase mutations and aortic lesions are associated with distribution of circulating monocytes in histiocytosis (160 Online Views)

Jerome Razanamahery, Helene Greigert, Matthias Papo, Jean-Francois Emile, Julien Guy, Francesco Pegoraro, Julien Haroche, Sylvain Audia, Maxime Samson, Bernard Bonnotte

https://doi.org/10.3324/haematol.2024.286716

Mar 20, 2025

Editorials

Guidelines

Recognition, prevention, and management of adverse events associated with asparaginase / pegaspargase treatment of acute lymphoblastic leukemia in adults: consensus of an expert panel (769 Online Views)

Emily Curran, Marlise R. Luskin, Houda Alachkar, Ibrahim Aldoss, Patrick W. Burke, Ryan D. Cassaday, Seth E. Karol, Anthony J. Perissinotti, Cecilie Utke Rank, Kjeld Schmiegelow, Jonathan Webster, Dan Douer

https://doi.org/10.3324/haematol.2024.286744

Articles

Lower incidence of chronic graft-versus-host disease after ruxolitinib plus extracorporeal photopheresis versus ruxolitinib alone in steroid-refractory acute graft-versus-host disease following allogeneic stem cell transplantation (1110 Online Views)

Iryna Lastovytska, Silke Heidenreich, Evgeny Klyuchnikov, Christian Niederwieser, Nico Gagelmann, Johanna Richter, Radwan Massoud, Kristin Rathje, Tetiana Perekhrestenko, Gaby Zeck, Catherina Lück, Dietlinde Janson, Christine Wolschke, Francis Ayuk, Nicolaus Kröger

https://doi.org/10.3324/haematol.2024.286824

Isatuximab plus bortezomib, lenalidomide, and dexamethasone for transplant-ineligible newly diagnosed multiple myeloma patients: a frailty subgroup analysis of the IMROZ trial (2105 Online Views)

Salomon Manier, Meletios-Athanasios Dimopoulos, Xavier P. Leleu, Philippe Moreau, Michele Cavo, Hartmut Goldschmidt, Robert Z. Orlowski, Muriel Tron, Christina Tekle, Marie-France Brégeault, Andrea T. Shafer, Meral Beksac, Thierry Facon

https://doi.org/10.3324/haematol.2024.287200

Letters to the Editor

Clonal hematopoiesis is common in bone marrow of patients with classical Hodgkin lymphoma (306 Online Views)

Rebeca Iglesias, Eva Díaz, Sara Fernández, Marta Miguélez, María De Rosa Torres, Mirna L. Domínguez, José L. Solórzano, Mónica Estévez, Raquel Oña, Alejandro M. Bobes, Carlos Montalbán, Adolfo de la Fuente, Juan F. García

https://doi.org/10.3324/haematol.2024.286579

Doubling in median survival in patients diagnosed with multiple myeloma 2005-2019; a real-world study from the UK’s Haematological Malignancy Research Network (924 Online Views)

Alexandra Smith, Timothy Bagguley, Eve Roman, Simon Crouch, Russell Patmore, Ruth De Tute, Andy Rawstron, Gordon Cook, Frances Seymour, Christopher Parrish

https://doi.org/10.3324/haematol.2024.287095

Clonal hematopoiesis of indeterminate potential associates with higher risk of thromboembolism in severe COVID-19 (245 Online Views)

Gregorio Maria Bergonzi, Jacques-Emmanuel Galimard, Federico Mario Aletti, Piera Angelillo, Sara Mastaglio, Federico Erbella, Diego Palumbo, Giliola Calori, Patrizia Rovere Querini, Cristina Tresoldi, Gabriele Fragasso, Francesco De Cobelli, Andrea Angelo Assanelli, Fabio Ciceri, Matteo G. Della Porta, Annalisa Ruggeri, Massimo Bernardi

https://doi.org/10.3324/haematol.2024.287128

Predictors of response to pacritinib therapy and survival among 60 Mayo Clinic patients with myelofibrosis treated outside of clinical trials (378 Online Views)

Maymona Abdelmagid, Jeanne M. Palmer, Aref Al-Kali, Mehrdad Hefazi, James Foran, Kebede H. Begna, Cecilia Y. Arana Yi, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi

https://doi.org/10.3324/haematol.2025.287576

Dissecting CD47 expression in lymphoid neoplasms to inform precision immunotherapy with anti-CD47 phagocytic checkpoint blockade (441 Online Views)

Andrea Marra, Alan Ramsay, Samuel Chamberlain-Keene, Gabriela Soares, Maurilio Ponzoni, Sugerdana Padmasri, Manuel Rodriguez-Justo, Sabine Pomplun, Ian Proctor, Anna Childerhouse, Alsharabati Muntasser, Mario Cioce, Vito Michele Fazio, German Ott, Miguel Piris, Brunangelo Falini, Teresa Marafioti

https://doi.org/10.3324/haematol.2024.286864

Case Reports

NPM1 mutation subtype switch in acute myeloid leukemia (296 Online Views)

Benjamin Podvin, Romane Joudinaud, Christophe Roumier, Augustin Boudry, Laure Farnault, Mélinda Dantec, Céline Berthon, Florent Dumezy, Laure Goursaud, Maxime Bucci, Claude Preudhomme, Nicolas Duployez

https://doi.org/10.3324/haematol.2024.286916

Mar 13, 2025

Editorials
Article

Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia (1447 Online Views)

Shanna M. Hogeling, Duy Minh Lê, Nikita La Rose, Min Chul Kwon, Albertus T.J. Wierenga, Fiona A.J. van den Heuvel, Vincent van den Boom, Anna Kuchnio, Ulrike Philippar, Gerwin Huls, Jan Jacob Schuringa

https://doi.org/10.3324/haematol.2024.285616

Editorials
Letter to the Editor

40 is the new 50: reducing the need for platelet transfusions prior to lumbar puncture in adults with hematologic malignancies (472 Online Views)

Kristen Corrao, Adrian Umpierrez, Angela Treml, Aniko Szabo, Laura Michaelis, Lyndsey Runaas, Guru Subramanian Guru Murthy, Sameem Abedin, Karen Carlson, Lisa Baumann Kreuziger, Ehab Atallah

https://doi.org/10.3324/haematol.2023.284321

Articles

Hemophilia is associated with accelerated biological aging (901 Online Views)

Marina Trappl, Rafaela Vostatek, Manuel Salzmann, Daniel Kraemmer, Johanna Gebhart, Philipp Hohensinner, Ingrid Pabinger, Cihan Ay

https://doi.org/10.3324/haematol.2024.286421

Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis (435 Online Views)

Maria Elena Boggio Merlo, Maria Mallardo, Lucilla Luzi, Giulia De Conti, Chiara Caprioli, Roman Hillje, Mario Faretta, Cecilia Restelli, Andrea Polazzi, Valentina Tabanelli, Angelica Calleri, Stefano Pileri, Pier Giuseppe Pelicci, Emanuela Colombo

https://doi.org/10.3324/haematol.2024.286577

Impact of hematopoietic cell transplantation and quizartinib in newly diagnosed patients with acute myeloid leukemia and FMS-like tyrosine kinase 3–internal tandem duplications in the QuANTUM-First trial (978 Online Views)

Richard F. Schlenk, Pau Montesinos, Hee-Je Kim, Antonio Romero-Aguilar, Radovan Vrhovac, Elżbieta Patkowska, Pavel Žak, Po-Nan Wang, James Hanyok, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Arnaud Lesegretain, Jorge Cortes, Mikkael A. Sekeres, Herve Dombret, Sergio Amadori, Jianxiang Wang, Alexander E. Perl, Mark J. Levis, Harry P. Erba

https://doi.org/10.3324/haematol.2024.286623

Bruton tyrosine kinase covalent inhibition shapes the immune microenvironment in chronic lymphocytic leukemia (862 Online Views)

Daniel Medina-Gil, Laura Palomo, Víctor Navarro, Gonzalo Lázaro, Beatriz Martín-Mur, Cristina Hernández, Oriol Castells, Belén Sánchez, Pau Marc Muñoz-Torres, Carlota Pagès, Gemma Pujadas, Anna Esteve-Codina, Alba Cabirta, Christelle Ferrà, Miguel Alcoceba, Maria José Terol, Rafael Andreu, Mercè Martí, Pau Abrisqueta, Francesc Bosch, Marta Crespo; Spanish Group of Chronic Lymphocytic Leukemia - GELLC (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286663

Real-world comparison of lisocabtagene maraleucel and axicabtagene ciloleucel in large B-cell lymphoma: an inverse probability of treatment weighting analysis with 3-year follow up (1910 Online Views)

Andrew J. Portuguese, Jennifer J. Huang, Yein Jeon, Mahnoosh Taheri, Aya Albittar, Emily C. Liang, Alexandre V. Hirayama, Erik L. Kimble, Lorenzo Iovino, Christina Poh, Ajay K. Gopal, Mazyar Shadman, Brian G. Till, Filippo Milano, Aude G. Chapuis, Folashade Otegbeye, Ryan D. Cassaday, Ryan S. Basom, Qian Vicky Wu, David G. Maloney, Jordan Gauthier

https://doi.org/10.3324/haematol.2024.287010

Regulation of immune responses to therapeutic factor VIII by transplacental delivery of Fc-fused immunodominant factor VIII domains or peptides (259 Online Views)

Alejandra Reyes-Ruiz, Sandrine Delignat, Aurélien Azam, Victoria Daventure, Leslie Dourthe, Angelina Mimoun, Geneviève McCluskey, Maria T. Georgescu, David Lillicrap, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes

https://doi.org/10.3324/haematol.2024.287057

Letters to the Editor

Case Reports

Plasma exchange for hyperammonemia-induced reduced consciousness after PEG-asparaginase in an adult patient with acute lymphoblastic leukemia (230 Online Views)

Felix Klingler, Anika Forstreuter, Luisa Stegat, Sofie Kämereit, Felix Ullrich, Florian Udonta, Christian Krebs, Dominik Wichmann, Carsten Bokemeyer, Nicola Goekbuget, Walter Fiedler, Franziska Modemann

https://doi.org/10.3324/haematol.2024.286972

Mar 6, 2025

Review Series on Acute Leukemia

Articles

Increased RhoA pathway activation downstream of αIIbβ3/SRC contributes to heterozygous Bernard Soulier syndrome (666 Online Views)

Larissa Lordier, Christian A. Di Buduo, Alexandre Kauskot, Nathalie Balayn, Cécile Lavenu-Bombled, Francesco Baschieri, Valérie Proulle, Cecilia P. Marin Oyarzun, Francesca Careddu, Ida Biunno, Tudor Manoliu, Philippe Rameau, Isabelle Plo, Nicolas Papadopoulos, Stefan Constantinescu, William Vainchenker, Guillaume Nam Nguyen, Paola Ballerini, Remi Favier, Alessandra Balduini, Hana Raslova

https://doi.org/10.3324/haematol.2024.286424

Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62 (1066 Online Views)

Kirk A. Taylor, Amro Elgheznawy, Recep Adiyaman, Tyler L. Horn, Sarah Parkes, Craig E. Hughes, Liam J. McGuffin, Jonathan M. Gibbins

https://doi.org/10.3324/haematol.2024.286466

Revaccination with pneumococcal conjugate vaccine five years after primary immunization improves immunity in patients with chronic lymphocytic leukemia (513 Online Views)

Magdalena Kättström, Bertil Uggla, Camilla Virta, Merit Melin, Nina Ekström, Anders Magnuson, Per-Ola Andersson, Ylva Hammarlund, Sandra Lockmer, Ingmar Nilsson, Daniel Roth, Magnus Svensson, Tobias Tolf, Eva Kimby, Torbjörn Norén, Simon Athlin

https://doi.org/10.3324/haematol.2024.286942

Letters to the Editor

Venetoclax combined with escalating doses of homoharringtonine, low-dose cytarabine, and granulocyte colony-stimulating factor demonstrates feasibility and tolerability for remission induction in pediatric acute myeloid leukemia (370 Online Views)

Shengqin Cheng, Li Gao, Jun Lu, Yixin Hu, Yi Wang, Hailong He, Jie Li, Suxiang Liu, Feiyun Yang, Xiaofang Wu, Liyan Fan, Junjie Fan, Yanhua Yao, Yina Sun, Bohan Li, Yongping Zhang, Shuiyan Wu, Cheng Cheng, Peifang Xiao, Raul C. Ribeiro, Hu Shaoyan

https://doi.org/10.3324/haematol.2024.286832

Hepatocyte senescence and persistent liver injury in Fanconi anemia (262 Online Views)

Jane Koo, Alana J. Snyder, Kathleen Campbell, Erica Miller, Allison O’Conner, Markus Grompe, Parinda A. Mehta, Kasiani C. Myers, Stella M. Davies

https://doi.org/10.3324/haematol.2024.287096

Comparison of isatuximab-pomalidomide-dexamethasone versus elotuzumab-pomalidomidedexamethasone in relapsed/refractory multiple myeloma patients: a target trial emulation using real-world data (1463 Online Views)

Enrica Antonia Martino, Annalisa Pitino, Massimo Offidani, Roberta Della Pepa, Alessandro Gozzetti, Velia Bongarzoni, Antonio Maroccia, Valeria Amico, Paola Stefanoni, Elena Zamagni, Sofia Terlizzi, Daniele Derudas, Salvatore Palmieri, Rosario Bianco, Concetta Conticello, Marino Brunori, Angela Rago, Flavia Lotti, Raffaele Fontana, Nicola Sgherza, Elena Rossi, Anna Maria Cafro, Massimiliano Arangio Febbo, Angela Maria Quinto, Claudio Cerchione, Gloria Margiotta Casaluci, Annalisa Citro, Catello Califano, Renato Zambello, Silvia Mangiacavalli, Carmine Liberatore, Gabriele Buda, Claudio De Magistris, Angela Amendola, Ernesto Vigna, Antonella Bruzzese, Emiliano Barbieri, Micol Quaresima, Daniela Roccotelli, Francesca Farina, Jacopo Micozzi, Iolanda Donatella Vincelli, Giuseppe Tarantini, Elisabetta Antonioli, Sara Aquino, Alessandro Maggi, Alessandra Lombardo, Giuseppe Bertuglia, Anna Furlan, Anna Mele, Ombretta Annibali, Emilia Cotzia, Pietro Benvenuti, Lorenzo De Paoli, Gregorio Barilà, Sonia Morè, Valerio De Stefano, Francesco Di Raimondo, Maria Teresa Petrucci, Niccolò Bolli, Pellegrino Musto, Antonino Neri, Fortunato Morabito, Giovanni Tripepi, Massimo Gentile

https://doi.org/10.3324/haematol.2025.287325

Comments

Feb 27, 2025

Editorials
Letter to the Editor

Integrated genomic analysis to reduce chromosomal analysis for the diagnosis of pediatric hematologic malignancies: addressing the shortage of cytogenetic technologists (355 Online Views)

Dong Li, Sarah K. Tasian, Gerald Wertheim, Susan R. Rheingold, Kathrin M. Bernt, Haley Newman, Luanne Wainwright, Donna M. Wilmoth, Brian Thiel, Lea F. Surrey, Elizabeth Margolskee, Vinodh Pillai, Minjie Luo, Michele E. Paessler, Stephen P. Hunger, Marilyn M. Li, Yiming Zhong

https://doi.org/10.3324/haematol.2024.286924

Editorials
Article

Mortality risk after cancer-related venous thromboembolism has decreased over the last three decades: the HUNT and Tromsø studies (415 Online Views)

Nikolai H. Eide, Camilla Langholm, Fridtjof B. Rinde, Nick van Es, Kristian Hveem, Sigrid K. Brækkan, John-Bjarne Hansen, Vânia M. Morelli

https://doi.org/10.3324/haematol.2024.286407

Articles

Maintenance therapy with oral decitabine plus cedazuridine after allogeneic stem cell transplantation for myelodysplastic syndrome (477 Online Views)

Portia Smallbone, Terri Lynn Shigle, Oren Paslovsky, Chitra Hosing, Amin Alousi, Qaiser Bashir, Yosra Aljawai, Jeremy Ramdial, Uday Popat, Richard Champlin, Elizabeth J. Shpall, Betül Oran

https://doi.org/10.3324/haematol.2024.287177

Letters to the Editor

Prognostic relevance of variant allelic frequency for treatment outcomes in patients with acute myeloid leukemia: a study by the Spanish PETHEMA registry (404 Online Views)

Rafael Colmenares, Noemi Alvarez, Eva Barragan, Blanca Boluda, Maria J. Larrayoz, Maria Carmen Chillon, Elena Soria-Saldise, Cristina Bilbao, Joaquin Sanchez-Garcia, Teresa Bernal, David Martinez-Cuadron, Cristina Gil, Josefina Serrano, Carlos Rodriguez-Medina, Juan Bergua, Jose A. Perez-Simon, Maria Calbacho, Juan M. Alonso-Dominguez, Jorge Labrador, Mar Tormo, Pilar Herrera-Puente, Cristina Martin-Arriscado, Andres Arroyo-Barea, Inmaculada Rapado, Claudia Sargas, Iria Vazquez, Maria J. Calasanz, Teresa Gomez-Casares, Ramon Garcia-Sanz, Rebeca Rodriguez-Veiga, Joaquin Martinez-Lopez, Rosa Ayala, Pau Montesinos; PETHEMA Group (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286311

Molecular predictors of response and survival in patients with relapsed/refractory acute myeloid leukemia following venetoclax plus hypomethylating agent therapy (447 Online Views)

Isla M. Johnson, Rimal Ilyas, Kristen McCullough, Aref Al-Kali, Hassan B. Alkhateeb, Kebede H. Begna, Abhishek Mangaonkar, Antoine Saliba, Mark R. Litzow, William Hogan, Mithun Shah, Mrinal M. Patnaik, Animesh Pardanani, Ayalew Tefferi, Naseema Gangat

https://doi.org/10.3324/haematol.2024.286991

Community respiratory viruses are generally well-tolerated in hematopoietic stem cell transplant recipients: a brief report from the TRANSPIRE study (269 Online Views)

Meghan Haney, Arfa Ashraf, Kelly E. Lake, Lauren Strecker, Kasiani C. Myers, Christopher Towe, Laura Walkup, Jason Woods, Stephanie L. Edwards, Richard Cooper, Leslie E. Lehmann, Gabriel Salinas Cisneros, Jason L. Freedman, K. Scott Baker, Erin Doherty, Margaret L. MacMillan, Samuel B. Goldfarb, Stella M. Davies, Jane Koo; TRANSPIRE Groups (Collaborative Group)

https://doi.org/10.3324/haematol.2024.287107

Case Reports

Ex vivo drug response profiling guides therapy in a case of high-risk acute undifferentiated leukemia with PICALM::MLLT10 (333 Online Views)

Elena Mastrodicasa, Luca Pagliaro, Valentina Pierini, Valentina Bardelli, Mariateresa Giaimo, Raffaella Zamponi, Anna Montanaro, Katia Tragni, Roberta Arcaleni, Maria Speranza Massei, Ilaria Capolsini, Katia Perruccio, Elena Varotto, Barbara Buldini, Andrea Gherli, Silvia Romoli, Caterina Matteucci, Maria Crocioni, Francesco Arcioni, Grazia Gurdo, Carla Cerri, Maurizio Caniglia, Giovanni Roti, Roberta La Starza

https://doi.org/10.3324/haematol.2024.286815

Comments

Feb 20, 2025

Review Articles

Articles

Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial (501 Online Views)

Tuomas Lahteenmaki Taalas, Trausti Oskarsson, Mats Heyman, Bendik Lund, Kristi Lepik, Goda Vaitkevičiene, Olafur Gisli Jonsson, Julia Eriksson, Nina Toft, Laimonas Griškevičius, Helene Hallbook, Katrin Palk, Ulla Wartiovaara-Kautto, Petter Quist-Paulsen, Ulrika Noren-Nystrom, Kim Vettenranta, Jonas Abrahamsson, Kjeld Schmiegelow, Paivi M Lahteenmaki

https://doi.org/10.3324/haematol.2024.286043

Chronic lymphocytic leukemia often arises by a multiclonal selection process (2677 Online Views)

Davide Bagnara, Andrea N Mazzarello, Niccolò Cardente, Stefano Vergani, Siddha Kasar, Stacey Fernandes, Gerardo Ferrer, Fabio Ghiotto, Jacqueline C Barrientos, Jonathan E Kolitz, Kanti R Rai, Steven L Alen, Monica Colombo, Franco Fais, Jennifer R Brown, Manlio Ferrarini, Nicholas Chiorazzi

https://doi.org/10.3324/haematol.2024.286380

Letters to the Editor

A phase II trial of azacitidine with ipilimumab, nivolumab, or ipilimumab and nivolumab in previously untreated myelodysplastic syndrome (533 Online Views)

Ian M. Bouligny, Guillermo Montalban-Bravo, Koji Sasaki, Naval Daver, Elias Jabbour, Yesid Alvarado, Courtney D. DiNardo, Farhad Ravandi, Gautam Borthakur, Prithviraj Bose, Naveen Pemmaraju, Steven Kornblau, Tapan Kadia, Lucia Masarova, Koichi Takahashi, Michael Andreeff, Alexandre Bazinet, Hui Yang, Rashmi Kanagal-Shamanna, Chitra Hosing, Sherry Pierce, Meghan Meyer, Xuelin Huang, Guillermo Garcia-Manero

https://doi.org/10.3324/haematol.2024.286559

Venetoclax in combination with hypomethylating agents in newly diagnosed and relapsed CBFβ::MYH11+ acute myeloid leukemia (471 Online Views)

Ziyu Feng, Xiaohui Hu, Weiyang Li, Ting Xu, Yang Xu, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Yanming Zhang, Depei Wu, Ying Wang

https://doi.org/10.3324/haematol.2024.286836

Feb 13, 2025

Editorials
Article

Venetoclax in combination with a pediatric-inspired regimen for the treatment of newly diagnosed adults with Philadelphia chromosome-negative acute lymphoblastic leukemia (1280 Online Views)

Ibrahim Aldoss, Jianying Zhang, Kathryn Shimamoto, Caner Saygin, Marjorie Robbins, Vaibhav Agrawal, Ahmed Aribi, Diren Arda Karaoglu, Hoda Pourhassan, Paul Koller, Haris Ali, Amanda Blackmon, Salman Otoukesh, Karamjeet Sandhu, Brian Ball, Andrew S. Artz, Monzr M. Al Malki, Amandeep Salhotra, Jose Tinajero, Zhaohui Gu, Ian Lagman, Michelle Velasquez, Jacqueline Dang, Pamela S. Becker, Michelle Afkhami, Lucy Ghoda, Wendy Stock, Stephen J Forman, Anthony Stein, Guido Marcucci, Vinod Pullarkat

https://doi.org/10.3324/haematol.2024.286427

Articles

Mortality risk after cancer-related venous thromboembolism has decreased over the last three decades: the HUNT and Tromsø studies (415 Online Views)

Nikolai H. Eide, Camilla Langholm, Fridtjof B. Rinde, Nick van Es, Kristian Hveem, Sigrid K. Brækkan, John-Bjarne Hansen, Vânia M. Morelli

https://doi.org/10.3324/haematol.2024.286407

Overall cancer risk in people with deleterious germline DDX41 variants (651 Online Views)

Sophia C. Korotev, Jason X. Cheng, Yogameenakshi Haribabu, Joshua Strauss, Salina Dominguez, Ashwin Koppayi, Melody Perpich, Madeline Pies, Luke Moma, Aelin Kim, Hatice Basdag, Courtnee Rodgers, Satyajit Kosuri, Ryunosuke Saiki, Hideki Makishima, Sanjukta Tawde, Shelly Galasinski, Priscilla Kandikatla, Hari Prasanna Subramanian, Kehan Ren, Honghao Bi, Mona Mohammadhosseini, Seishi Ogawa, Peng Ji, Anupriya Agarwal, Soma Das, Lucy A. Godley

https://doi.org/10.3324/haematol.2024.286887

Letters to the Editor

Oncogenic NTRK3 mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia (294 Online Views)

Sunil K. Joshi, Ariane Huang, Janét Pittsenbarger, Ujwal Shinde, Camilo Posso, Paul D. Piehowski, Sara J.C. Gosline, Richard D. Press, Marina A. Gritsenko, Chelsea Hutchinson, Karl K. Weitz, Kevin Watanabe-Smith, Nicola Long, Karin D. Rodland, Jeffrey W. Tyner, Brian J. Druker, Cristina E. Tognon

https://doi.org/10.3324/haematol.2024.285572

Blinatumomab in induction therapy improves molecular response in untreated adults with Ph- B-cell precursor acute lymphoblastic leukemia (494 Online Views)

Cyril Salek, Stepan Hrabovsky, Frantisek Folber, Zdenek Koristek, Jan M. Horacek, Eva Fronkova, Leona Rezkova Reznickova, Pavla Pecherkova, Petr Soukup, Barbora Dluhosova, Vaclava Polivkova, Jitka Krizkova, Katerina Machova Polakova, Zuzana Vrzalova, Hana Halamova, Jan Trka, Petr Cetkovsky, Michael Doubek

https://doi.org/10.3324/haematol.2024.287062

Case Reports

One CHiP to rule them all? Mechanistic insight into carfilzomib-induced lung injury with neutrophil extracellular trap formation following cellular immunotherapy (324 Online Views)

Julia Katharina Scholz, Lena Stabel, Nora Rebecca Schwingen, Jasmin Knopf, Anna-Sophie Flatt, Tobias Bäuerle, Stefan Krause, Heidi Waibel, Moritz Leppkes, K Martin Kortüm, Hermann Einsele, Andreas Mackensen, Martin Herrmann, Simon Völkl, Fabian Müller

https://doi.org/10.3324/haematol.2024.286596

Feb 6, 2025

Editorials
Article

Recipient sex and donor leukemic cell characteristics determine leukemogenesis in patient-derived models (772 Online Views)

Anna M.P. Stanger, Marlon Arnone, Pauline Hanns, Lucca M. Kimmich, Jessica Kübler, Sarah Gekeler, Elsa S. Görsch, Lea Kramer, Marcelle Baer, Jan C. Schroeder, Taylor S. Mills, Martina Konantz, Saskia S. Rudat, Claudia Lengerke

https://doi.org/10.3324/haematol.2023.284647

Review Articles

Spotlight Review

Articles

Deep immunophenotypic dissection and clinical impact of T cells in the follicular lymphoma microenvironment (769 Online Views)

Sary El Daker, David Qualls, Andriy Derkach, Samida Beqaj, Leonardo Boiocchi, Venkatraman Seshan, Jeeyeon Baik, Menglei Zhu, Gilles Salles, Ahmet Dogan, Mikhail Roshal, Pallavi Galera

https://doi.org/10.3324/haematol.2024.286383

Letters to the Editor

Update on long-term outcomes of a cohort of patients with TCF3::HLF positive acute lymphoblastic leukemia treated with blinatumomab and stem cell transplantation (711 Online Views)

Aida Zeckanovic, Brice Mouttet, Luciana Vinti, Philip Ancliff, Benoît Brethon, Gunnar Cario, Sarah Elitzur, Volkan Hazar, Joachim Kunz, Anja Möricke, Jerry Stein, Yöntem Yaman, Jochen Buechner, Magnus Aasved Hjort, David O’Connor, Angus Hodder, Jack Bartram, Julia Alten, Draga Barbaric, Gabriele Escherich, Nicolas Boissel, Loïc Vasseur, Emmanuelle Clappier, Laure Farnault, Sarah Bonnet, Katharine Patrick, Martin Schrappe, Sema Anak, André Baruchel, Franco Locatelli, Martin Stanulla, Arend von Stackelberg, Nicole Bodmer, Jean-Pierre Bourquin

https://doi.org/10.3324/haematol.2024.286111

Dexamethasone added to induction and post-remission therapy in older patients with newly diagnosed acute myeloid leukemia: a multicenter, phase II trial (DEXAML-02) (456 Online Views)

Sarah Bertoli, Emilie Bérard, Pierre Peterlin, Romain Guieze, Yohan Desbrosses, Yosr Hicheri, Omar Benbrahim, Martin Carre, Corentin Orvain, Anne Banos, Marc Bernard, Emmanuel Gyan, Alain Saad, Safia Chebrek, Gabrielle Roth Guepin, Veronique Dorvaux, Laurence Sanhes, Maria Pilar Gallego-Hernanz, Carole Exbrayat, Laure Vincent, Chantal Himberlin, Célestine Simand, Norbert Vey, Cindy Fenoll, Ariane Mineur, Anne Huynh, Francois Vergez, Isabelle Luquet, Laetitia Largeaud, Eric Delabesse, Arnaud Pigneux, Christian Récher; French Innovative Leukemia Organization FILO (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286807

Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation (557 Online Views)

Eva N. Hamulyák, Tzu-Fei Wang, Lisa Baumann Kreuziger, Varun Iyengar, Brian J. Carney, Ann Hoeben, Berna C. Özdemir, Rosana D. Cordova Serrano, Kristen M. Sanfilippo, Shira Rozenblatt, Ludo F.M. Beenen, Shlomit Yust-Katz, Erez Halperin, Ariela Arad, Aharon Lubetsky, Marc Carrier, Benjamin Massat, Harry R. Büller, Galia Spectre, Jeffrey I. Zwicker, Avi Leader; ABC Study Group (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286973

Case Reports

Nontuberculous mycobacterial infections following teclistamab in multiple myeloma (610 Online Views)

Matthew Ho, Luca Paruzzo, Janna Minehart, Teja Voruganti, Pooja Devi, Dan T. Vogl, Adam D. Cohen, Alfred L. Garfall, Adam J. Waxman, Shivani Kapur, Edward A. Stadtmauer, Sandra Susanibar Adaniya, Sarah Longworth

https://doi.org/10.3324/haematol.2024.286675

Comments

Jan 30, 2025

Articles

Letters to the Editor

40 is the new 50: reducing the need for platelet transfusions prior to lumbar puncture in adults with hematologic malignancies (472 Online Views)

Kristen Corrao, Adrian Umpierrez, Angela Treml, Aniko Szabo, Laura Michaelis, Lyndsey Runaas, Guru Subramanian Guru Murthy, Sameem Abedin, Karen Carlson, Lisa Baumann Kreuziger, Ehab Atallah

https://doi.org/10.3324/haematol.2023.284321

High immunoproteasome and low constitutive proteasome subunit levels correlate with sensitivity to bortezomib-containing chemotherapy: update from the Children’s Oncology Group AALL1231 trial (419 Online Views)

Margot S. F. Roeten, Johan van Meerloo, Suzanne N. van Dijk, Zinia Kwidama, Gaye Jenkins, David T. Teachey, Meenakshi Devidas, Mignon L. Loh, Gertjan J. L. Kaspers, Sonja Zweegman, Gerrit Jansen, Terzah M. Horton, Jacqueline Cloos

https://doi.org/10.3324/haematol.2024.286171

Integrated genomic analysis to reduce chromosomal analysis for the diagnosis of pediatric hematologic malignancies: addressing the shortage of cytogenetic technologists (355 Online Views)

Dong Li, Sarah K. Tasian, Gerald Wertheim, Susan R. Rheingold, Kathrin M. Bernt, Haley Newman, Luanne Wainwright, Donna M. Wilmoth, Brian Thiel, Lea F. Surrey, Elizabeth Margolskee, Vinodh Pillai, Minjie Luo, Michele E. Paessler, Stephen P. Hunger, Marilyn M. Li, Yiming Zhong

https://doi.org/10.3324/haematol.2024.286924

Case Reports

Very long-term remission with azacitidine in VEXAS syndrome (641 Online Views)

Lin-Pierre Zhao, Vincent Jachiet, Olivier Kosmider, Lise Larcher, Emmanuelle Clappier, Marie Sébert, Lionel Adès, Pierre Hirsch, Thibault Mahévas, Maxime Battistella, Jean-David Bouaziz, Arsène Mekinian, Pierre Fenaux; MINHEMON FRENVEX (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286641

Comments
Letter to the Editor

FLT3 ligand kinetic profile predicts response to treatment in patients with high-risk myelodysplastic syndrome/chronic myelomonocytic leukemia receiving CPX-351: a study from the Groupe Francophone des Myélodysplasies (799 Online Views)

Pierre Peterlin, Joëlle Gaschet, Pascal Turlure, Marie-Pierre Gourin, Pierre-Yves Dumas, Sylvain Thepot, Ana Berceanu, Sophie Park, Marie-Anne Hospital, Thomas Cluzeau, Jose-Miguel Torregrosa-Diaz, Louis Drevon, Rosa Sapena, Fatiha Chermat, Lionel Ades, Sophie Dimicoli-Salazar, Maxime Jullien, Pierre Fenaux, Patrice Chevallier.

https://doi.org/10.3324/haematol.2024.286025

Comments

Comments

Jan 23, 2025

Letters to the Editor

Pre-phase treatment with rituximab and high-dose methotrexate to re-evaluate eligibility for intensive induction treatment of frail patients with central nervous system lymphoma (487 Online Views)

Julia Wendler, Richard I. Lewis, Alexandra Kutilina, Markus Knott, Lisa Kristina Isbell, Elke Valk, Peter Borchmann, Jan-Michel Heger, Gerald Illerhaus, Elisabeth Schorb

https://doi.org/10.3324/haematol.2024.286347

H2-K1 protects murine MLL-AF9 leukemia stem cells from natural killer cell-mediated immune surveillance (469 Online Views)

Somadri Ghosh, Maria Rodriguez-Zabala, Gladys Telliam Dushime, Katrin Reinbach, Ramprasad Ramakrishnan, Ewa Sitnicka, Marcus Järås; Lymphoid Development and Regulation (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286468

Myeloma cell growth suppression by osteoblast-derived extracellular vesicles: the creation of a non-permissive niche for myeloma cells by bone-forming osteoblasts (454 Online Views)

SooHa Kim, Jumpei Teramachi, Masahiro Hiasa, Ryota Amachi, Ariunzaya Bat-Erdene, Asuka Oda, Hirofumi Tenshin, Mariko Tanaka, Motosumi Nakagawa, Aiko Seki, Yoshihiko Sawa, Ken-ichi Matsuoka, Eiji Tanaka, Takeshi Harada, Tatsuya Tominaga, Masahiro Abe

https://doi.org/10.3324/haematol.2024.286554

Real-life outcome after failure to venetoclax and hypomethylating-based therapy for acute myeloid leukemia (505 Online Views)

Carlos Jiménez-Vicente, Iago Arribas, Helena Pomares, Guillermo Ramil, Sandra Castaño-Diez, Amanda Isabel Pérez-Valencia, Antonella Luciana Sturla, Mònica López-Guerra, Alexandra Martinez-Roca, Inés Zugasti, Francesca Guijarro, Albert Cortés-Bullich, Beatriz Merchán, Ana Triguero, Inés Monge, Albert Tuca, Guadalupe Oñate, Ana Garrido, Jorge Sierra, Montserrat Arnan, Jordi Esteve, Marina Díaz-Beyá; Spanish CETLAM Group (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286589

Opportunistic bone density assessment using pre-treatment [18F]FDG-PET/CT identifies fracture risk in lymphoma patients undergoing corticosteroid-containing chemotherapy (351 Online Views)

Genevieve Douglas, Kane M. Nicholls, Erin Paul, Zoe Loh, Sze-Ting Lee, Kathryn L Hackman, Cherie Chiang, Niamh Waters, Geoffrey Chong, Ashvind Prabahran, Eliza A. Hawkes

https://doi.org/10.3324/haematol.2024.286618

Prevalence and mortality trends of hemoglobinopathies in Italy: a nationwide study (609 Online Views)

Barbara Gianesin, Frédéric B. Piel, Khaled M. Musallam, Susanna Barella, Maddalena Casale, Elena Cassinerio, Rosario Di Maggio, Antonia Gigante, Maria Rita Gamberini, Giovanna Graziadei, Roberto Lisi, Filomena Longo, Aurelio Maggio, Raffaella Origa, Annamaria Pasanisi, Silverio Perrotta, Antonio Giulio Piga, Valeria Maria Pinto, Rosamaria Rosso, Giacomo Robello, Giovanna Russo, Marco Zecca, Lucia De Franceschi, Gian Luca Forni; Italian Hemoglobinopathies National Survey Group (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286886

Case Reports

Jan 16, 2025

Letters to the Editor

Targeting the membrane-proximal domain of CD33 to maximize the efficacy of natural killer cell-based immunotherapies (363 Online Views)

Sheryl Y. T. Lim, Frances M. Cole, George S. Laszlo, Margaret C. Lunn-Halbert, Jenny Huo, Junyang Li, Allie R. Kehret, Roland B. Walter

https://doi.org/10.3324/haematol.2024.286593

Ethnicity in systemic AL amyloidosis may impact risk stratification (419 Online Views)

Jahanzaib Khwaja, Sriram Ravichandran, Oliver Cohen, Darren Foard, Ana Martinez – Naharro, Lucia Venneri, Carol Whelan, Philip N. Hawkins, Julian Gillmore, Helen J. Lachmann, Shameem Mahmood, Marianna Fontana, Ashutosh Wechalekar

https://doi.org/10.3324/haematol.2024.286746

Case Reports

Jan 9, 2025

Editorials
Article

Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance (1785 Online Views)

Marta Anna Sobas, Amin T. Turki, Angela Villaverde Ramiro, Alberto Hernández-Sánchez, Javier Martinez Elicegui, Teresa González, Raúl Azibeiro Melchor, María Abáigar, Laura Tur, Daniele Dall'Olio, Eric Sträng, Jesse M. Tettero, Gastone Castellani, Axel Benner, Konstanze Döhner, Christian Thiede, Klaus H. Metzeler, Torsten Haferlach, Frederik Damm, Rosa Ayala, Joaquín Martínez-López, Ken I Mills, Jorge Sierra, Sören Lehmann, Matteo G. Della Porta, Jiri Mayer, Dirk Reinhardt, Rubén Villoria Medina, Renate Schulze-Rath, Martje Barbus, Jesús María Hernández-Rivas, Brian J.P Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger

https://doi.org/10.3324/haematol.2024.285805

Review Articles

Review Series on Acute Leukemia

Articles

Recipient sex and donor leukemic cell characteristics determine leukemogenesis in patient-derived models (772 Online Views)

Anna M.P. Stanger, Marlon Arnone, Pauline Hanns, Lucca M. Kimmich, Jessica Kübler, Sarah Gekeler, Elsa S. Görsch, Lea Kramer, Marcelle Baer, Jan C. Schroeder, Taylor S. Mills, Martina Konantz, Saskia S. Rudat, Claudia Lengerke

https://doi.org/10.3324/haematol.2023.284647

Letters to the Editor

Purine metabolites regulate leukemic cell sensitivity toward cytarabine (671 Online Views)

Xiaowen Zhang, Ang Jia, Jianwei You, Zixuan Zhuang, Yinfei Wang, Ting Liu, Xingrong Du, Linzhang Huang, Peng Li, Tong-Jin Zhao, Craig T. Jordan, Li Chen, Ji-Hao Zhou, Haobin Ye

https://doi.org/10.3324/haematol.2024.286308

Tyrosine kinase inhibitor discontinuation in nonallografted Philadelphia-positive acute lymphoblastic leukemia patients: a Campus ALL real-life study (657 Online Views)

Matteo Dragani, Michela Ansuinelli, Cristina Papayannidis, Nicola Fracchiolla, Valeria Cardinali, Michele Cedrone, Fabio Guolo, Salvatore Perrone, Prassede Salutari, Elisabetta Todisco, Robin Foà, Sabina Chiaretti

https://doi.org/10.3324/haematol.2024.286325

Serum B-cell maturation antigen could be a simple and accurate biomarker to identify and prognosticate monoclonal gammopathy of undetermined significance and smoldering multiple myeloma (607 Online Views)

Masanori Toho, Daisuke Ikeda, Shuichi Aikawa, Chiho Misono, Mitsuaki Oura, Fuminari Fujii, Hajime Sakuma, Atsushi Uehara, R ikako Tabata, Kentaro Narita, Masami Takeuchi, Tomohisa Watari, Yoshihito Otsuka, Kosei Matsue

https://doi.org/10.3324/haematol.2024.286842

Case Reports

High-dose intravenous immunoglobulin may be an efficient treatment option for patients with late-onset high-grade immune effector cell-associated hematotoxicity refractory to standard therapies (335 Online Views)

Yousef Laham, Shimrit Ringelstein-Harlev, Daniel Kurnik, Riva Fineman, Dana Yehudai-Ofir, Lilach Bonstein, Noga Setter-Marco, Eyal Braun, Itai Ghersin, Tsila Zuckerman, Ofrat Beyar-Katz

https://doi.org/10.3324/haematol.2024.286714

Jan 2, 2025

Editorials
Article

Acid ceramidase controls proteasome inhibitor resistance and is a novel therapeutic target for the treatment of relapsed / refractory multiple myeloma (795 Online Views)

Ryan T. Bishop, Tao Li, Praneeth Sudalagunta, Mostafa Nasr, Karl J. Nyman, Raghunandan R. Alugubelli, Mark Meads, Jeremy Frieling, Niveditha Nerlakanti, Marilena Tauro, Bin Fang, Steven Grant, John Koomen, Ariosto S. Silva, Kenneth H. Shain, Conor C. Lynch

https://doi.org/10.3324/haematol.2024.285587

Articles

FLI1 and GATA1 govern TLN1 transcription: new insights into FLI1-related platelet disorders (685 Online Views)

Elisa Gabinaud, Laurent Hannouche, Mathilde Veneziano-Broccia, Johannes Van Agthoven, Justine Suffit, Julien Maurizio, Delphine Potier, Dominique Payet-Bornet, Delphine Bastelica, Elisa Andersen, Manal Ibrahim-Kosta, Timothée Bigot, Céline Falaise, Anne Vincenot, Pierre-Emmanuel Morange, Paul Saultier, Marie-Christine Alessi, Marjorie Poggi; Hemostasis Unit of Lille (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286372

Letters to the Editor

Overlapping DNA methylation changes in enhancers in clonal cytopenia of undetermined significance and myelodysplastic neoplasm patients with TET2, IDH2, or DNMT3A mutations (427 Online Views)

Katja Kaastrup, Morten Tulstrup, Jakob W. Hansen, Claudia Schöllkopf, Klas Raaschou-Jensen, Andreas D. Ørskov, Bo Porse, Peter A. Jones, Joachim Weischenfeldt, Linn Gillberg, Kirsten Grønbæk

https://doi.org/10.3324/haematol.2024.285466

Case Reports

A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies (341 Online Views)

Fabiana Busti, Annalisa Castagna, Giacomo Marchi, Alice Vianello, Fabio Chesini, Claudia Bozzini, Camila dos Santos Lima, Nicola Martinelli, Elizabeta Nemeth, Tomas Ganz, Domenico Girelli

https://doi.org/10.3324/haematol.2024.286413

Dec 19, 2024

Review Articles

Clinical and laboratory risk factors for sickle cell retinopathy and maculopathy: a scoping review of the current evidence (434 Online Views)

Rajani P. Brandsen, Roselie M.H. Diederen, Gizem Kocabas, Erfan Nur, Arjan Malekzadeh, Reinier O. Schlingemann, Bart J. Biemond

https://doi.org/10.3324/haematol.2024.286420

Articles

Metabolic profile evolution in relapsed/refractory B-cell non-Hodgkin lymphoma patients treated with CD19 chimeric antigen receptor T-cell therapy and implications in clinical outcome (1023 Online Views)

Serena De Matteis, Laura Del Coco, Federica De Castro, Anna Maria Giudetti, Beatrice Casadei, Francesco Iannotta, Francesco De Felice, Enrica Tomassini, Francesca Vaglio, Maria Naddeo, Irene Salamon, Gianluca Storci, Noemi Laprovitera, Daria Messelodi, Salvatore Nicola Bertuccio, Marta Tassoni, Barbara Sinigaglia, Francesco Barbato, Margherita Ursi, Elena Campanini, Enrico Maffini, Marcello Roberto, Cinzia Pellegrini, Elisa Dan, Chiara Pirazzini, Paolo Garagnani, Manuela Ferracin, Pier Luigi Zinzani, Francesco Paolo Fanizzi, Massimiliano Bonafè, Francesca Bonifazi

https://doi.org/10.3324/haematol.2024.285154

Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia (1447 Online Views)

Shanna M. Hogeling, Duy Minh Lê, Nikita La Rose, Min Chul Kwon, Albertus T.J. Wierenga, Fiona A.J. van den Heuvel, Vincent van den Boom, Anna Kuchnio, Ulrike Philippar, Gerwin Huls, Jan Jacob Schuringa

https://doi.org/10.3324/haematol.2024.285616

Potassium/sodium cation carriers robustly up-regulate CD20 antigen by targeting MYC, and synergize with anti-CD20 immunotherapies to eliminate malignant B cells (980 Online Views)

Anna Torun, Aleksandra Zdanowicz, Nina Miazek-Zapala, Piotr Zapala, Bhaskar Pradhan, Marta Jedrzejczyk, Andrzej Ciechanowicz, Zofia Pilch, Marcin Skorzynski, Mikołaj Słabicki, Grzegorz Rymkiewicz, Joanna Barankiewicz, Claudio Martines, Luca Laurenti, Marta Struga, Magdalena Winiarska, Jakub Golab, Magdalena Kucia, Mariusz Z. Ratajczak, Adam Huczynski, Dinis P. Calado, Dimitar G. Efremov, Abdessamad Zerrouqi, Beata Pyrzynska

https://doi.org/10.3324/haematol.2024.285826

Molecular measurable residual disease by immunoglobulin gene rearrangements on circulating tumor DNA predicts outcome in diffuse large B-cell lymphoma (709 Online Views)

Roberta Soscia, Giovanni Manfredi Assanto, Irene Della Starza, Riccardo Moia, Donatella Talotta, Vittorio Bellomarino, Teresa Bellissimo, Marco Antonacci, Luigi Petrucci, Gianluca Gaidano, Anna Guarini, Maurizio Martelli, Alice Di Rocco, Robin Foà, Ilaria Del Giudice

https://doi.org/10.3324/haematol.2024.286331

Dec 12, 2024

Articles

Cancer-related thrombosis: impact of biological sex on the risk of rethrombosis and bleeding (577 Online Views)

Silvia García Adrián, Claudia Iglesias Pérez, Alberto Carmona-Bayonas, Laura Ortega Morán, Jaime Rubio Pérez, Purificación Martínez del Prado, Eva Martínez de Castro, Fernando Neria, Isaura Fernández Pérez, Marta García de Herreros, Marta Carmona Campos, Ignacio García Escobar, Rut Porta Balanyà, David Marrupe González, Paula Jiménez Fonseca, María Esperanza Guirao García, Manuel Sánchez Cánovas, José Muñoz Langa, Pedro Pérez Segura, Ma José Méndez Vidal, Andrés J. Muñoz Martín; Spanish Society of Medical Oncology (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286152

FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4 (629 Online Views)

Mariarosaria Miranda, Bjarke Endel Hansen, Batoul Wehbi, Valeria Porcheddu, Floris P.J. van Alphen, Paul Kaijen, Karin Fijnvandraat, Sebastien Lacroix-Desmazes, Maartje van den Biggelaar, Bernard Maillere, Jan Voorberg; EDUC8 Consortium (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286204

Characterization of tumor microenvironment and cell interaction patterns in testicular and diffuse large B-cell lymphomas (1117 Online Views)

Matias Autio, Oscar Brück, Marjukka Pollari, Marja-Liisa Karjalainen-Lindsberg, Klaus Beiske, Judit Mészaros Jørgensen, Harald Holte, Teijo Pellinen, Suvi-Katri Leivonen, Sirpa Leppä

https://doi.org/10.3324/haematol.2024.286267

Clinical interrogation of TP53 aberrations and its impact on survival in patients with myeloid neoplasms (4539 Online Views)

Jayastu Senapati, Sanam Loghavi, Guillermo Garcia-Manero, Guillin Tang, Tapan Kadia, Nicholas J. Short, Hussein A. Abbas, Naszrin Arani, Courtney D. DiNardo, Gautam Borthakur, Naveen Pemmaraju, Betul Oran, Elizabeth Shpall, Uday Popat, Richard Champlin, Sherry Pierce, Sankalp Arora, Ghayas Issa, Musa Yilmaz, Keyur Patel, Koichi Takahashi, Guillermo Montalban-Bravo, Danielle Hammond, Fadi G. Haddad, Farhad Ravandi, Hagop M. Kantarjian, Naval G. Daver

https://doi.org/10.3324/haematol.2024.286465

Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension (559 Online Views)

Alejandra Reyes-Ruiz, Sandrine Delignat, Aishwarya Sudam Bhale, Victoria Daventure, Robin V. Lacombe, Leslie Dourthe, Olivier Christophe, Sune Justesen, Krishnan Venkataraman, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes

https://doi.org/10.3324/haematol.2024.286536

Letters to the Editor

Comments

Dec 5, 2024

Articles

Acid ceramidase controls proteasome inhibitor resistance and is a novel therapeutic target for the treatment of relapsed / refractory multiple myeloma (795 Online Views)

Ryan T. Bishop, Tao Li, Praneeth Sudalagunta, Mostafa Nasr, Karl J. Nyman, Raghunandan R. Alugubelli, Mark Meads, Jeremy Frieling, Niveditha Nerlakanti, Marilena Tauro, Bin Fang, Steven Grant, John Koomen, Ariosto S. Silva, Kenneth H. Shain, Conor C. Lynch

https://doi.org/10.3324/haematol.2024.285587

Reduced GATA1 levels are associated with ineffective erythropoiesis in sickle cell anemia (1225 Online Views)

Sara El Hoss, Panicos Shangaris, John Brewin, Maria Eleni Psychogyiou, Cecilia Ng, Lauren Pedler, Helen Rooks, Érica M. F. Gotardo, Lucas F. S. Gushiken, Pâmela L. Brito, Kypros H Nicolaides, Nicola Conran, David C. Rees, John Strouboulis

https://doi.org/10.3324/haematol.2024.286010

Air pollution, residential greenspace, and the risk of incident immune thrombocytopenic purpura: a prospective cohort study of 356,482 participants (776 Online Views)

Peiyang Luo, Feifan Wang, Jiacheng Ying, Ke Liu, Baojie Hua, Shuhui Chen, Jiayu Li, Xiaohui Sun, Ding Ye, Baodong Ye, Jinyi Tong, Keding Shao, Yingying Mao

https://doi.org/10.3324/haematol.2024.286328

Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy (649 Online Views)

Wolfgang Bethge, Sarah Flossdorf, Franziska Hanke, Christoph Schmid, Mark Ringhoffer, Stefan Klein, Bernd Hertenstein, Johannes Schetelig, Matthias Stelljes, Thomas Schroeder, Igor Wolfgang Blau, Francis Ayuk, Matthias Eder, Robert Zeiser, Katharina Fleischhauer, Nicolaus Kröger, Peter Dreger

https://doi.org/10.3324/haematol.2024.286385

Letters to the Editor

Bone-independent extramedullary disease is associated with inferior overall survival in multiple myeloma patients: a single-center, real-world experience (448 Online Views)

Ke Xu, Charles Agbuduwe, Nickolaos Kanellias, William Wilson, Annabel McMillan, Xenofon Papanikolaou, Lydia Lee, Rakesh Popat, Jonathan Sive, Neil Rabin, Kwee Yong, Agapi Parcharidou, Charalampia Kyriakou

https://doi.org/10.3324/haematol.2024.286409

Nov 21, 2024

Review Articles

Nov 14, 2024

Editorials

Nov 7, 2024

Articles

Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance (1785 Online Views)

Marta Anna Sobas, Amin T. Turki, Angela Villaverde Ramiro, Alberto Hernández-Sánchez, Javier Martinez Elicegui, Teresa González, Raúl Azibeiro Melchor, María Abáigar, Laura Tur, Daniele Dall'Olio, Eric Sträng, Jesse M. Tettero, Gastone Castellani, Axel Benner, Konstanze Döhner, Christian Thiede, Klaus H. Metzeler, Torsten Haferlach, Frederik Damm, Rosa Ayala, Joaquín Martínez-López, Ken I Mills, Jorge Sierra, Sören Lehmann, Matteo G. Della Porta, Jiri Mayer, Dirk Reinhardt, Rubén Villoria Medina, Renate Schulze-Rath, Martje Barbus, Jesús María Hernández-Rivas, Brian J.P Huntly, Gert Ossenkoppele, Hartmut Döhner, Lars Bullinger

https://doi.org/10.3324/haematol.2024.285805

Venetoclax in combination with a pediatric-inspired regimen for the treatment of newly diagnosed adults with Philadelphia chromosome-negative acute lymphoblastic leukemia (1280 Online Views)

Ibrahim Aldoss, Jianying Zhang, Kathryn Shimamoto, Caner Saygin, Marjorie Robbins, Vaibhav Agrawal, Ahmed Aribi, Diren Arda Karaoglu, Hoda Pourhassan, Paul Koller, Haris Ali, Amanda Blackmon, Salman Otoukesh, Karamjeet Sandhu, Brian Ball, Andrew S. Artz, Monzr M. Al Malki, Amandeep Salhotra, Jose Tinajero, Zhaohui Gu, Ian Lagman, Michelle Velasquez, Jacqueline Dang, Pamela S. Becker, Michelle Afkhami, Lucy Ghoda, Wendy Stock, Stephen J Forman, Anthony Stein, Guido Marcucci, Vinod Pullarkat

https://doi.org/10.3324/haematol.2024.286427

Oct 31, 2024

Review Articles

Oct 17, 2024

Letters to the Editor

Exposure toxicity of venetoclax in acute myeloid leukemia patients in the real-life setting: impact of high exposure on delayed neutropenia (703 Online Views)

Florent Puisset, Emmanuel Raffoux, Lionel Ades, Tony Huynh, Raphaël Itzykson, Didier Bouscary, Loréa Aguinana, Florence Rabian, Marie Sebert, Anne Vekhoff, Eolia Brissot, Mohamad Mohty, Agnes Bonnin, Alexis Genthon, Jeremie Zerbit, Lise Willems, Justine Decrocq, Adrien Contejean, Etienne Lengline, Samia Mourah, Lauriane Goldwirt

https://doi.org/10.3324/haematol.2024.286062

Sep 26, 2024

Letters to the Editor

Aug 19, 2021

Errata Corrige

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (4016 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2021.279802

May 10, 2018

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells (1612 Online Views)

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

https://doi.org/10.3324/haematol.2018.189399