Vol. 111 No. s1 (2026): Abstract book of the XIX Congress of the Italian Society of Experimental Hematology, Florence, 4-6 March 2026

A01 | T-cell exhaustion in hematological malignancies (200 Online Views)

Interdepartmental Centre for Stem Cells and Regenerative Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

https://doi.org/10.3324/haematol.2026.s1.1

A02 | Role of metabolic alterations in the marrow microenvironment in the response to immunotherapy in multiple myeloma (167 Online Views)

M. Cea

Chair of Hematology, Department of Internal Medicine and Medical Specialties - DiMI, University of Genoa

IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy

https://doi.org/10.3324/haematol.2026.s1.2

A03 | Pathogenetic significance of circulating biomarkers: the role of microvesicles (127 Online Views)

L. Catani

Istituto di Ematologia "L. e A. Seràgnoli", Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

https://doi.org/10.3324/haematol.2026.s1.3

A04 | The new technological challenges of liquid biopsy: the genomic and fragmentomic landscape from cfDNA (170 Online Views)

R. Moia

Università del Piemonte Orientale, Novara, Italy

https://doi.org/10.3324/haematol.2026.s1.4

A05 | TP53 in lymphoproliferative neoplastic disorders (162 Online Views)

G. M. Rigolin

Hematology. St. Anna University Hospital, Ferrara, Italy

https://doi.org/10.3324/haematol.2026.s1.5

A06 | TP53 in myeloid neoplasms (157 Online Views)

M. T. Voso¹, L. Guarnera¹

¹ Department of Biomedicine and Prevention, University of Rome Tor Vergata, Italy

https://doi.org/10.3324/haematol.2026.s1.6

A07 | Optical genome mapping: the new frontier of cytogenomic diagnosis? (164 Online Views)

L. Zanatta

U.O.S. Citogenetica e Citogenomica, ULSS2 Marca Trevigiana, Treviso, Italy

https://doi.org/10.3324/haematol.2026.s1.7

A08 | Clonal hematopoiesis, myeloid neoplasms and bone marrow failure syndromes (164 Online Views)

E. Attardi

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

Department of Hematology, St. Jude Children’s Research Hospital, Memphis, USA

https://doi.org/10.3324/haematol.2026.s1.8

A09 | Defining the clonal complexity and biology of gene-modified hematopoiesis in gene therapy (149 Online Views)

P. Quaranta¹, G. Pacini¹, L. Seffin^1|2, L. Basso-Ricci¹, F. Benedicenti¹, S. Giannelli¹, I. Monti¹, C. Perini¹, S. Mazza¹, S. Darin³, F. Tucci³, F. Ferrua³, V. Calbi³, A. Calabria¹, E. Montini¹, M. E. Bernardo¹, M. P. Cicalese^1|3, A. Aiuti^1|2|3, S. Scala¹

¹ San Raffaele Telethon Institute for Gene Therapy - SR-TIGET, San Raffaele Scientific Institute, Milan, Italy

² Università Vita-Salute San Raffaele, Milan, Italy

³ Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy

https://doi.org/10.3324/haematol.2026.s1.9

B02 | Circulating plasma cells drive disease dissemination in multiple myeloma, independent of clonality (120 Online Views)

I. Vigliotta¹, A. Varacalli¹, M. Talarico^1|2, V. Solli², B. Taurisano², S. Armuzzi², I. Pistis¹, V. M. Vuong², A. Vitale¹, G. Mazzocchetti², E. Borsi¹, A. Croce², M. Martello², A. Poletti², C. Nanni³, K. Mancuso^1|2, M. Puppi^1|2, E. Zamagni^1|2, C. Terragna¹

¹ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

² Department of Medical and Surgical Sciences - University of Bologna

³ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Nuclear Medicine, Italy

https://doi.org/10.3324/haematol.2026.s1.10

B03 | Clonal hematopoiesis in follicular lymphoma: analysis of the phase III FIL FOLL12 trial (152 Online Views)

N. Maher^1|2, R. Moia², M. Almasri², E. Genuardi³, M. Drandi³, C. Cosentino², R. Soscia⁴, G.. Assanto⁴, A. Tucci⁵, C. Boccomini⁶, P. Corradini⁷, J. Olivieri⁸, L. Arcaini^9|10, F. Ballerini¹¹, F. Cavallo^12|13, B. Puccini¹⁴, C. Patti¹⁵, C. Stelitano¹⁶, A. Pulsoni¹⁷, A. Santoro¹⁸, A. Pinto¹⁹, V.R. Zilioli²⁰, L. Marcheselli²¹, S. Ciavarella²², R. Bomben²³, S. Galimberti²⁴, I. Del Giudice⁴, M. Ladetto¹, G. Gaidano², S. Luminari²⁵, S. Ferrero³

¹ SCDU Ematologia, Department of Translational Medicine, AOU SS Antonio e Biagio E Cesare Arrigo, Università del Piemonte Orientale

² Division of Hematology, Department of Translational Medicine, AOU Maggiore della Carità di Novara, Università del Piemonte Orientale

³ Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Torino

⁴ Hematology, Department of Translational and Precision Medicine, ‘Sapienza’ University of Rome – AOU Policlinico Umberto I

⁵ Division of Hematology, ASST Spedali Civili

⁶ Hematology Division, A. O. U. Città della Salute e della Scienza di Torino

⁷ Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori

⁸ Hematology and SCT Unit, Azienda Sanitaria Universitaria Integrata Santa Maria della Misericordia

⁹ Division of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia

¹⁰ Department of Molecular Medicine, University of Pavia

¹¹ IRCCS Ospedale Policlinico San Martino

¹² Division of Hematology, University Hospital A. O. U. "Città della Salute e della Scienza"

¹³ Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Turin

¹⁴ Hematology Unit, Careggi University Hospital

¹⁵ Oncohematology Azienda Ospedali Riuniti Villa Sofia-V. Cervello Palermo

¹⁶ Grande Ospedale Metropolitano, Bianchi Melacrino Morelli, Ematologia Reggio Calabria

¹⁷ Department of Hematology, SM Goretti Hospital, University Polo Pontino

¹⁸ IRCCS Humanitas Research Hospital, Transplantation Unit Department of Oncology and Haematology

¹⁹ Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori-IRCCS-Fondazione 'G. Pascale'

²⁰ Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda

²¹ Uffici Studi Fondazione Italiana Linfomi

²² Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II'

²³ Centro di Riferimento Oncologico di Aviano

²⁴ Hematology Division, Pisa University Hospital, Department of Clinical and Experimental Medicine, University of Pisa

²⁵ Ematologia, Azienda Unità Sanitaria Locale – IRCCS Reggio Emilia, Italy

https://doi.org/10.3324/haematol.2026.s1.11

B04 | Intraclonal diversification in immunoglobulin light chain genes refines prognostication in early-stage chronic lymphocytic leukemia (146 Online Views)

J. Nabki¹, F. Vit², B. A. Deeban¹, M. Almasri¹, C. Cosentino¹, F. Bokaei¹, L. Cividini¹, S. Mouhssine¹, N. Maher¹, M. Schipani¹, M. Bellia¹, R. Dondolin¹, J. Ghanej¹, F. Maiellaro¹, E. Secomandi¹, S. Kogila¹, S. Rasi¹, A. Zucchetto², T. Bittolo², G. Gaidano¹, R. Bomben², V. Gattei², R. Moia¹

¹ Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

² Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano CRO, IRCCS, Udine, Italy

https://doi.org/10.3324/haematol.2026.s1.12

B05 | Ectopic activation of FOXF1 and FENDRR by t(14;16)(q32;q24) identifies a high-risk T-ALL/MPAL subtype (138 Online Views)

D. Di Giacomo^1|2|3, P. Pölönen¹, V. Bardelli², S. Kimura¹, V. Pierini², L. Pagliaro⁴, S. Arniani², Y. Chang¹, Q. Gao¹, L. E. Montefiori¹, C. Matteucci², S. Lei¹, W. Rosikiewicz⁵, C. Nardelli², A. G. L. Fernandez², A. Østergaard¹, E. A. B. Wagner¹, P. Baviskar¹, M. Cerrano⁶, M. Leocin⁷, A. Manabe⁸, S. Hirabayashi⁸, J. Takita⁹, D. Hasegawa¹⁰, S. Miyamoto¹⁰, A. Macchiarulo¹¹, J. Xu^12|13, D.T. Teachey¹⁴, G. Roti⁴, I. Iacobucci¹, R. La Starza², C. Mecucci², C. G. Mullighan^1|15

¹ Department of Pathology, St. Jude Children's Research Hospital

² Laboratory of Molecular Medicine

³ Department of Chemistry, Biology and Biotechnology, University of Perugia

⁴ Department of Medicine and Surgery, Translational Hematology and Chemogenomics

⁵ Center for Applied Bioinformatics, St. Jude Children's Research Hospital

⁶ S. C. Ematologia, AOU Città della Salute e della Scienza - Presidio Molinette

⁷ Hematology Unit, Ospedale dell'Angelo

⁸ Department of Pediatrics, Hokkaido University Graduate School of Medicine

⁹ Department of Pediatrics, Graduate School of Medicine Kyoto University

¹⁰ Department of Pediatrics St. Luke's International Hospital

¹¹ Department of Pharmaceutical Sciences, University of Perugia

¹² Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania

¹³ Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania

¹⁴ Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia

¹⁵ Center of Excellence for Leukemia Studies, St. Jude Children's Research Hospital

https://doi.org/10.3324/haematol.2026.s1.13

B06 | Integrating pharmacogenomics and microenvironment profiling in high-risk leukemias (121 Online Views)

¹ Department of Medicine and Surgery, University of Parma

² Department of General and Specialist Medicine, Hematology and Hematopoietic Stem Cell Transplant, AOU di Parma

³ Translational Hematology and Chemogenomics “THEC”, University of Parma

⁴ Department of Medical and Surgical Sciences, University of Bologna

⁵ IRCCS AOU di Bologna, Istituto di Ematologia “Seràgnoli”

⁶ Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST “Dino Amadori”

⁷ Hematology Unit, Ospedale di Rimini

⁸ Department of Hematology, Azienda USL-IRCCS di Reggio Emilia

⁹ Department of Oncohematology, Ospedale “Guglielmo da Saliceto”

¹⁰ Department of Medical Sciences, University of Ferrara

https://doi.org/10.3324/haematol.2026.s1.14

B07 | Molecular risk profiling in myeloproliferative neoplasms blast phase treated with venetoclax and decitabine: a three-gene score for survival prediction (138 Online Views)

¹ Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze

² SOD Ematologia, AOU Careggi

³ Centro Ricerca e Innovazione Malattie Mieloproliferative CRIMM, AOU Careggi

⁴ Fondazione GIMEMA

https://doi.org/10.3324/haematol.2026.s1.15

B08 | Clinical role of peripheral blood leukemia stem cells at diagnosis in chronic myeloid leukemia: final results of the Prospective Flowers Study (132 Online Views)

A. Sicuranza¹, P. Pacelli¹, A. Santoni¹, E. Abruzzese², D. Cattaneo³, A. Iurlo³, L. Luciano⁴, S. Galimberti⁵, V. Giai⁶, O. Mulas⁷, G. Caocci⁷, F. Sorà⁸, I. Capodanno⁹, M. Crugnola¹⁰, A. Gozzini¹¹, S. Russo¹², M. Annunziata¹³, C. Fozza¹⁴, A. Cartocci¹⁵, S. Fredducci¹, E. Pacini¹, A.M. Liberati¹⁶, M. Defina¹, E. Bestoso¹, C. Marzano¹, D. Tocci¹, T. Miracapillo¹, C. Turriziani¹, K. Peccia¹, D. Raspadori¹, M. Bocchia¹

¹ Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese

² Sant'Eugenio Hospital, Tor Vergata University

³ Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico

⁴ Hematology - Department of Clinical Medicine and Surgery, Federico II University

⁵ Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa

⁶ Division of Hematology, Città Della Salute e Della Scienza

⁷ Department of Medical Sciences and Public Health, University of Cagliari

⁸ Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore

⁹ SOC Ematologia Azienda USL-IRCSS di Reggio Emilia

¹⁰ Ematologia e Centro BMT, Azienda Ospedaliero-Universitaria di Parma

¹¹ Hematology Unit, AOU Careggi, University of Florence

¹² Hematology, University of Messina

¹³ Hematology Unit, Hospital 'Antonio Cardarelli'

¹⁴ Department of Medical, Surgical and Experimental Sciences, University of Sassari

¹⁵ Department of Medical Sciences, surgery and neurosciences, University of Siena

¹⁶ Università degli studi di Perugia - Struttura Complessa di Oncoematologia

https://doi.org/10.3324/haematol.2026.s1.16

CO01 | A novel highly recurrent fusion circRNA from the kmt2a::aff1 fusion gene impacting mitochondrial metabolism in B-ALL with the t(4;11)(q21.3-q22.1;q23.3) translocation (133 Online Views)

D. Tolomeo¹, M. Bardini², S. Venuto¹, G. Visci¹, A. Lonoce¹, L. Calamo¹, I. Cifola³, M. Severgnini³, M. Mastrodonato¹, D. Semeraro¹, L. Valsecchi², M. Mauri⁴, R. La Starza⁵, M. Lucarelli⁵, A. Azzariti⁶, S. Serrati⁶, A. Ferrari⁷, G. Martinelli⁸, N. Santoro⁹, M. Fumagalli², G. Cazzaniga^2|4, G. Fazio^2|4, C.T. Storlazzi¹

¹ Department of Biosciences, Biotechnologies, and Environment, University of Bari Aldo Moro

² Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori

³ Institute for Biomedical Technologies

⁴ School of Medicine and Surgery, University of Milano-Bicocca

⁵ Hematology and Bone Marrow Transplantation Section, Department of Medicine and Surgery, University of Perugia, Centro di Ricerche EmatoOncologiche, Azienda di Perugia

⁶ IRCCS Istituto Tumori "Giovanni Paolo II"

⁷ Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori - IRST "Dino Amadori"

⁸ Department of Hematology and Oncology Sciences, Institute of Haematology "L. and A. Seràgnoli", S. Orsola University Hospital

⁹ Pediatric Oncology AOUC of Policlinico of Bari

https://doi.org/10.3324/haematol.2026.s1.17

CO02 | Genomic screening of primary refractory acute myeloid leukemia without TP53 alterations by optical genome mapping (144 Online Views)

R. Maffei¹, S. Martinelli¹, B. Conte², F. Bettelli², L. Bonamici², P. Barozzi², A. Paolini¹, F. Giacobbi¹, G. Corradini¹, F. Pilato¹, G. Debbia², S. Cordella², A. Cassanelli², F. Cretì², M. Morselli², L. Potenza², D. Giusti², E. Colaci², P. Bresciani², A. Cuoghi², A. Gilioli², A. Messerotti², V. Pioli², M. Maccaferri², G. Leonardi², R. Marasca², A. Candoni², F. Forghieri², M. Luppi², E. Tagliafico¹

¹ Department of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics, Azienda Ospedaliero-Universitaria, Policlinico

² Hematology Unit, and Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria, Policlinico

https://doi.org/10.3324/haematol.2026.s1.18

CO03 | Functional study of circRNA with altered expression in T-ALL and circRNA-driven T-ALL subtype classification (103 Online Views)

A. Caregari^1|2, S. H. Anjedani^3|2, E. Gaffo¹, A. Cani³, G. Veltri³, E. Rampazzo⁴, A. Teramo⁴, S. Hu⁵, J. Kluiver⁵, B. Buldini^3|6, V. Serafin^3|7, S. Bresolin³, S. Bortoluzzi¹

¹ Computational Genomics Group, Department of Oncology, Surgery and Gastroenterology, University of Padua

² Department of Biology, University of Padua

³ Pediatric hematology, oncology and hematopoietic cell & gene therapy, Pediatric Research Institute, Città della Speranza

⁴ Department of Molecular Medicine, University of Padua

⁵ Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen

⁶ Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, University of Padua

⁷ Department of Biomedical, Metabolic and Neural Sciences, Cellular Signalling Unit, University of Modena and Reggio Emilia

https://doi.org/10.3324/haematol.2026.s1.19

CO05 | Identification of wnk1 as a druggable target in TAL1-related T-cell acute lymphoblastic leukemia (136 Online Views)

A. Montanaro¹, G. Monica¹, A. D’antuono¹, R. Zamponi², G. Sammarelli², G. Todaro², R. La Starza², C. Mecucci³, M. Giaimo¹, A. Gherli¹, F. Vento¹, B. Lorusso¹, E. Simoncini¹, L. Pagliaro^1|2, C. R. Jimenez⁴, F. Quaini¹, G. Roti^1|2

¹ Department of Medicine and Surgery, University of Parma, Parma, Italy

² Hematology and BMT Unit, Azienda Ospedaliero-Universitaria di Parma, Italy

³ Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria Della Misericordia Hospital, Perugia, Italy

⁴ OncoProteomics Laboratory, Cancer Center Amsterdam, Amsterdam University Medical Centers, VU University, Amsterdam, The Netherlands

https://doi.org/10.3324/haematol.2026.s1.20

CO06 | Absent CD38 expression negatively impacts and further discriminates outcome on the high-risk subgroup Ph-like acute lymphoblastic leukemia (109 Online Views)

L. V. Cappelli¹, F. Kaiser¹, G. Marinucci¹, M. Di Trani¹, D. Cardinali¹, M.S. De Propris¹, L. Fucci¹, M. Martelli¹, R. Foà¹, S. Chiaretti¹

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University

https://doi.org/10.3324/haematol.2026.s1.21

CO07 | Single-cell sequencing reveals pathways and perturbations predictive of central nervous system dissemination in B-cell acute lymphoblastic leukemia (131 Online Views)

L.V. Cappelli¹, F. Iannelli², D. Cardinali¹, L. Fumagalli², A. Natoni¹, F. Kaiser¹, M. Di Trani¹, S. Chiaretti¹, R. Chiarle^2|3|4, S. Pileri², R. Foà¹

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University

² Division of Hematopathology, IEO European Institute of Oncology IRCCS

³ Department of Pathology, Children's Hospital and Harvard Medical School

⁴ Department of Molecular Biotechnology and Health Sciences, University of Torino

https://doi.org/10.3324/haematol.2026.s1.22

CO08 | Flt3 as a new therapeutic target in preclinical models of pediatric BCP-ALL with PAX5 rearrangement (111 Online Views)

¹ Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori

² School of Medicine and Surgery, University of Milano Bicocca

³ Department of Paediatric Oncology, Haematology and Clinical Immunology, Heinrich-Heine and University Dusseldorf, Medical Faculty

⁴ Medical Genetics, School of Medicine and Surgery, University of Milan Bicocca

https://doi.org/10.3324/haematol.2026.s1.23

CO10 | Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression (150 Online Views)

G. Notarpietro¹, A. Bucci¹, M.C. Vegliante¹, B. Apollonio², S.A. Pappagallo¹, P. Mondelli¹, R. Daprile³, A. Scattone³, M. Frenquelli⁴, A. Guarini¹, G. Castellano⁵, A. Ciarrocchi⁶, B. Donati⁶, M. Ponzoni⁷, P. Ghia⁸, C. Minoia¹

¹ IRCCS Istituto Tumori "Giovanni Paolo II", Hematology Unit

² IRCCS Istituto Tumori "Giovanni Paolo II", Rare Tumors and Melanoma Unit

³ IRCCS Istituto Tumori "Giovanni Paolo II", Pathology Unit

⁴ San Raffaele Scientific Institute, B-cell Neoplasia Unit Division of Experimental Oncology

⁵ Institut d'Investigacions Biomèdiques August Pi i Sunyer - IDIBAPS

⁶ Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia

⁷ Medical School, Università Vita-Salute San Raffaele

⁸ Comprehensive Cancer Center, IRCCS Ospedale San Raffaele

https://doi.org/10.3324/haematol.2026.s1.24

CO11 | BCOR inactivation in B cells initiates CLL-like disease and enables study of disease evolution in a novel mouse model (93 Online Views)

D. Sorcini¹, A. Stella¹, F.M. Adamo¹, F. De Falco¹, R. Arcaleni¹, F. Gurrieri¹, E. Dorillo¹, A. Esposito¹, L. Valmarini¹, A. Atzeni¹, B. Bigerna², M.P. Martelli^1|2, P. Sportoletti^1|2

¹ Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research CREO, University of Perugia and Santa Maria della Misericordia Hospital

² Santa Maria della Misericordia Hospital

https://doi.org/10.3324/haematol.2026.s1.25

CO12 | Epigenetic regulation of CD49d expression in chronic lymphocytic leukemia: insights from bimodal CD49d cases (120 Online Views)

E. Tissino¹, N. Calonaci², F. Pozzo¹, L. T. Di Bergamo³, F. Vit¹, A. Stacchetti¹, R. Bergamin², T. Bittolo¹, R. Papotti¹, A. Gaglio¹, S. Cozzini⁴, M.I. Del Principe⁵, A. Chiarenza⁶, J. Olivieri⁷, F. Zaja⁸, D. Rossi³, R. Bomben¹, V. Gattei¹, G. Caravagna², A. Zucchetto¹

¹ Clinical and Experimental Onco-Hematology Unit, Centro Di Riferimento Oncologico di Aviano, CRO, IRCCS

² Cancer Data Science Laboratory, University of Trieste

³ Institute of Oncology Research, Oncology Institute of Southern Switzerland

⁴ Research and Technology Institute, Area Science Park

⁵ Ematologia, Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma Tor Vergata

⁶ Divisione di Ematologia, Ospedale Ferrarotto, A. O. U. Policlinico-OVE, Università di Catania

⁷ Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi" DISM, Azienda Ospedaliera Universitaria S. Maria Misericordia

⁸ Department of Medical, Surgical and Health Sciences, University of Trieste

https://doi.org/10.3324/haematol.2026.s1.26

CO13 | Dissection of biallelic NOTCH1 disruption in chronic lymphocytic leukemia reveals chromosome 9 copy neutral-loss of heterozygosity (100 Online Views)

G. Ianna¹, F.M. Rossi¹, F. Vit¹, E. Tissino¹, T. Bittolo¹, R. Papotti¹, A. Gaglio¹, M. Ballerini², F. Zaja², L. Laurenti³, J. Olivieri⁴, A. Chiarenza⁵, R. Laureana⁶, F. Esposito⁶, M. Postorino⁶, M.I. Del Principe⁶, A. Zucchetto¹, R. Bomben¹, V. Gattei¹, F. Pozzo¹

¹ Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano, CRO, IRCCS

² Department of Medical, Surgical and Health Sciences, University of Trieste

³ Istituto di Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS

⁴ Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi" DISM, Azienda Ospedaliera Universitaria S. Maria Misericordia

⁵ Divisione di Ematologia, Ospedale Ferrarotto, A. O. U. Policlinico-OVE, Università di Catania

⁶ Ematologia, Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma Tor Vergata

https://doi.org/10.3324/haematol.2026.s1.27

CO14 | A combined immunophenotypic and molecular approach to differentiate T-CUS, low-count T-LGLL and T-LGLL (121 Online Views)

¹ Department of Medicine, Hematology division, University of Padova

² Veneto Institute of Molecular Medicine - VIMM, Italy

https://doi.org/10.3324/haematol.2026.s1.28

CO15 | Optical genome mapping identifies multiple structural variation and catastrophic rearrangements in B-cell prolymphocytic leukemia (133 Online Views)

R. Maffei¹, A. Paolini¹, B. Conte², L. Bonamici², S. Giorgi², S. Martinelli¹, F. Giacobbi¹, G. Corradini¹, F. Pilato¹, G. Debbia², C.G. Atene², S. Cordella², A. Cassanelli², F. Cretì², M. Morselli², L. Potenza², D. Giusti², E. Colaci², F. Bettelli², P. Bresciani², A. Cuoghi², A. Gilioli², A. Messerotti², V. Pioli², M. Maccaferri², G. Leonardi², F. Forghieri², M. Luppi², R. Marasca², E. Tagliafico¹

¹ Department of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics, Azienda Ospedaliero-Universitaria, Policlinico

² Hematology Unit, and Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria, Italy

https://doi.org/10.3324/haematol.2026.s1.29

CO16 | Clinical and biological impact of plasma cytokine levels in newly diagnosed chronic lymphocytic leukemia (100 Online Views)

S. Mouhssine¹, C. Cosentino¹, M. Almasri¹, N. Maher¹, J. Nabki¹, L. Cividini¹, B. A. Deeban¹, F. Maiellaro¹, R. Dondolin¹, M. Bellia¹, E. Secomandi¹, V. Caneparo², A. Mahmoud¹, C. Deambrogi¹, S. Kogila¹, J. Ghanej¹, S. Rasi¹, G. Gaidano¹, R. Moia¹

¹ Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

² Center for Translational Research on Autoimmune & Allergic Diseases – CAAD, Università del Piemonte Orientale, Italy

https://doi.org/10.3324/haematol.2026.s1.30

CO18 | A novel anti-CD138 antibody AT801 to effectively deliver chitosan NBs for targeting of multiple myeloma and reverting tumor microenvironmental invasiveness (139 Online Views)

C. Tangredi^1|2, M. Argenziano³, D. Busato¹, S. Capolla¹, A. Zucchetto⁴, V. Gattei⁴, R. Cavalli³, P. Macor², G. Toffoli¹, M. D. Bo¹

¹ Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico di Aviano - CRO, IRCCS

² Department of Life Science, University of Trieste

³ Deparment of drug science and technology, University of Turin

⁴ Clinical and Experimental Onco-Hematology, Centro di Riferimento Oncologico di Aviano, IRCCS, Italy

https://doi.org/10.3324/haematol.2026.s1.31

CO19 | Identification by a single cell analysis of CCN5/Wisp2 as a possible marker of the osteogenic impairment in the myeloma bone microenvironment (151 Online Views)

C. Sitzia¹, M. Dessena¹, F. Mohammadi¹, T. Torelli², C. Manferdini³, A. Guidi², R. Vescovini¹, D. Toscani⁴, A. Poletti¹, N.T. Iannozzi¹, V. Raimondi¹, O. Lungu¹, S. Ricci⁴, G. Todaro⁴, G. Sammarelli⁴, B. D. Palma⁴, G. Lisignoli³, L. Agnelli², N. Giuliani^1|4, P. Storti¹

¹ Dipartimento di Medicina e Chirurgia, Università di Parma

² Dipartimento di Diagnostica Innovativa, IRCCS Istituto Nazionale dei Tumori

³ Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli

⁴ U. O. Ematologia e CTMO, Azienda Ospedaliero-Universitaria di Parma Programma Dipartimentale Mieloma Multiplo e Gammopatie Monoclonali, Italy

https://doi.org/10.3324/haematol.2026.s1.32

CO20 | Immune dysregulation in multiple myeloma: uncovering the role of non-malignant B cells (98 Online Views)

F. Viviani¹, F. Lazzaroni¹, E. Calvi¹, A. Matera¹, A. Marella², A. Maeda¹, M. Scopetti², C. De Magistris¹, L. Pettine¹, S. Fabris¹, S. Pioggia¹, A. Marchetti², C. Leoni², G. Castellano¹, M. Barbieri¹, S. Lonati², M. Lionetti², F. Passamonti^1|2, N. Bolli^1|2, M.C. Da Vià¹

¹ IRCCS Fondazione Ca’ Granda Ospedale Maggiore Policlinico

² Department of Oncology and Hemato-Oncology, University of Milan, Italy

https://doi.org/10.3324/haematol.2026.s1.33

CO21 | Integrated multiomic immune profiling defines the biological basis of minimal residual disease persistence in multiple myeloma (125 Online Views)

A.M. Corsale¹, M. Speciale², C. Aquilina¹, E. Gigliotta¹, A. Rizzuto¹, M. Biondo³, E. Tofacchi¹, A. Romano¹, M. Di Simone¹, A. Gallo⁴, N. Caccamo⁵, F. Dieli⁵, S. Meraviglia⁵, S. Siragusa¹, C. Botta¹

¹ Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, PROMISE, University of Palermo

² Department of Surgical, Oncological and Stomatological Disciplines, DICHIRONS, University of Palermo

³ Department of General Surgery and Medical-Surgical Specialties, Hematology Section, University of Catania

⁴ Department of Research, IRCCS-ISMETT, Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione

⁵ Department of Biomedicine, Neuroscience and Advanced Diagnosis, Bi. N. D. , University of Palermo

https://doi.org/10.3324/haematol.2026.s1.34

CO22 | UMG1-TriNK15: a first-in-class trispecific NK engager targeting multiple myeloma (149 Online Views)

S. Squillacioti¹, S. Signorelli¹, M. Gaetano¹, M. Vocaturo¹, M. Munir¹, C. Gentile¹, N. Polerà¹, E. Altomare¹, K. Grillone¹, P. Tagliaferri¹, P. Tassone¹, D. Caracciolo¹

¹ Department of Experimental and Clinical Medicine - DMSC, Magna Graecia University, Catanzaro, Italy

https://doi.org/10.3324/haematol.2026.s1.35

CO23 | Spatial imaging unlocks the potential of charting multiple myeloma and extramedullary disease (151 Online Views)

V. Desantis¹, A. Andriano¹, G. De Martino¹, T. Düking², O. Hartwig², G. Ingravallo³, M. Biondo⁴, C. Botta⁵, R. Ria⁶, A. Vacca⁶, A. G. Solimando⁶

¹ Department of Precision and Regenerative Medicine and Ionian Area-DiMePRe-J, Section of Pharmacology, University of Bari Aldo Moro Medical School

² Miltenyi Biotec B. V. & Co. KG

³ Pathological Anatomy Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro

⁴ Department of General Surgery and Medical-Surgical Specialties, University of Catania

⁵ Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo

⁶ Internal Medicine Guido Baccelli, University of Bari Aldo Moro Medical School, Italy

https://doi.org/10.3324/haematol.2026.s1.36

CO25 | P53 isoform diversity in multiple myeloma: unexplored risk factor beyond TP53 mutation and del(17p) (122 Online Views)

E. Borsi¹, A. Vitale², V. Solli², V. M. Vuong², M. Martello², I. Vigliotta¹, A. Poletti², S. Armuzzi², B. Taurisano², A. Varacalli^1|2, G. Mazzocchetti², A. Croce², I. Pistis¹, E. Zamagni^1|2, P. Tacchetti¹, I. Rizzello^1|2, C. Terragna¹

¹ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

² DIMEC – Dipartimento di Medicina e Chirurgia, Università di Bologna, Italy

https://doi.org/10.3324/haematol.2026.s1.37

CO26 | From precursor diseases to multiple myeloma: remodeling of the osteoblastic niche at single cell resolution (114 Online Views)

M. Dessena¹, F. Mohammadi¹, T. Torelli², C. Manferdini³, C. Sitzia¹, A. Guidi², R. Vescovini¹, M. Scita⁴, M. Bernardi⁴, D. Toscani⁴, A. Poletti¹, N.T. Iannozzi¹, V. Raimondi¹, O. Lungu¹, S. Ricci⁴, G. Todaro⁴, G. Sammarelli⁴, A. B. D. Palma⁴, G. Lisignoli³, L. Agnelli², N. Giuliani^1|4, P. Storti¹

¹ Dipartimento di Medicina e Chirurgia, Università di Parma

² Dipartimento di Diagnostica Innovativa, IRCCS Istituto Nazionale dei Tumori

³ Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli

⁴ U. O. Ematologia e CTMO, Azienda Ospedaliero-Universitaria di Parma Programma Dipartimentale Mieloma Multiplo e Gammopatie Monoclonali, Parma, Italy

https://doi.org/10.3324/haematol.2026.s1.38

CO27 | Targeting glutamine metabolism potentiates T cell engager–mediated immunotherapy in multiple myeloma (123 Online Views)

V. Raimondi¹, D. Toscani^1|2, R. Vescovini¹, O. Lungu¹, M. Dessena¹, C. Sitzia¹, N.T. Iannozzi¹, B. D. Palma², M. Scita², S. Ricci¹, P. Storti¹, N. Giuliani^1|2

¹ Laboratory of Hematology, Department of Medicine and Surgery, University of Parma

² Hematology, “Azienda Ospedaliero-Universitaria di Parma”, Italy

https://doi.org/10.3324/haematol.2026.s1.39

CO28 | NONO shapes multiple myeloma progression through paraspeckle-dependent and independent pathways (103 Online Views)

E. Taiana¹, V. Traini², A. Devecchi³, I. Silvestris², G. Fabbiano¹, N. Puccio⁴, I. Craparotta⁵, M. Bolis^5|6, R. Piva⁷, A. Neri⁸, L. Agnelli^3|9, F. Passamonti^1|2, N. Bolli^1|2, D. Ronchetti²

¹ Hematology, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico

² Department of Oncology and Hemato-Oncology, University of Milan

³ Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori

⁴ Laboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia

⁵ Oncology Department, Computational Oncology Unit, Mario Negri IRCCS

⁶ Bioinformatics Core Unit, Institute of Oncology Research - IOR

⁷ Department of Molecular Biotechnology and Health Sciences, University of Turin

⁸ Scientific Directorate, Azienda USL-IRCCS di Reggio Emilia

⁹ Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Italy

https://doi.org/10.3324/haematol.2026.s1.40

CO32 | ARQ531 targets MAPK–S6K1 signaling and synergizes with lenalidomide in RAS-mutant and wild-type multiple myeloma (122 Online Views)

D. Soncini^1|2, P. B. D², E. Gelli³, M. Chen⁴, A. Carreira⁵, P. A⁵, F. Ladisa², M. Squillario¹, I. Traverso², G. Giorgetti¹, M. Garibotto¹, F. Guolo^1|2, M. Piana¹, R.M. Lemoli^1|2, M. Cea^1|2

¹ IRCCS Ospedale Policlinico San Martino

² Clinic of Hematology, Department of Internal Medicine and Medical Specialties DiMI, University of Genoa

³ Genetics and Epigenetics of Behavior Laboratory, Fondazione Istituto Italiano di Tecnologia IIT

⁴ Harvard University

⁵ Department of Cellular, Computational and Integrative Biology CIBIO, University of Trento, Italy

https://doi.org/10.3324/haematol.2026.s1.41

CO33 | Variant-specific prognostic impact of SRSF2 p95 mutations in ASXL1-mutated myelodysplastic syndromes (172 Online Views)

L. Rigodanza^1|2, G. Mattiuz², S. De Pourcq², G. Andreossi², V. Santini²

¹ U.O.C. Ematologia, Ospedale San Bortolo, Vicenza

² MDS Unit, AOUC, Università di Firenze, Italy

https://doi.org/10.3324/haematol.2026.s1.42

CO34 | Developing a scalable model for genetic analysis of extra-myeloid tissues to resolve somatic-germline ambiguity in myeloid disorders (113 Online Views)

¹ Department of Biomedicine and Prevention, University of Rome Tor Vergata

² Medical Genetics Unit, Policlinico Tor Vergata, University of Rome Tor Vergata

³ Dermatology Unit, Policlinico Tor Vergata

⁴ Department of Biomedicine and Prevention, PhD program in immunology, molecular medicine, and applied biotechnologies, University of Rome Tor Vergata

⁵ Fondazione Policlinico Universitario Campus Bio-Medico

https://doi.org/10.3324/haematol.2026.s1.43

CO36 | TGF-β pathway deregulation in SF3B1-mutated low risk myelodysplastic syndrome patients (124 Online Views)

E. Lumia¹, E. Fabiani^2|3, P. Bielli², M. Sarchi⁴, M. Senatore², C. Fiducioso⁴, H. Hajrullaj², C. Iannini⁴, M. Rasicci², G. Silvestrini², N. Lelli¹, A. Onorato², A. Cristiano^1|5, M. Pieraccioli^6|7, F. Mallegni², F. Moretti², L. Guarnera¹, G. Falconi², S. Hutter⁸, N. Nadarajah⁸, T. Haferlach⁸, L. Malcovati^4|9, C. Sette², M.T. Voso²

¹ Department of Biomedicine and Prevention, PhD program in immunology, molecular medicine and applied biotechology, University of Tor Vergata

² Department of Biomedicine and Prevention, University of Tor Vergata

³ UniCamillus-Saint Camillus International University of Health Sciences

⁴ Department of Molecular Medicine, University of Pavia

⁵ Operative Research Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico

⁶ Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Hearth

⁷ GSTEP-Organoids Core Facility, Fondazione Policlinico Agostino Gemelli IRCCS

⁸ MLL Munich Leukemia Laboratory

⁹ Department of Hematology, Fondazione IRCCS Policlinico S. Matteo

https://doi.org/10.3324/haematol.2026.s1.44

CO40 | DNA methylation signatures are associated with clinical response to azacitidine in high-risk myelodysplastic syndrome patients (120 Online Views)

E. Lumia¹, A.G. L. Fernandez², E. Fabiani^3|4, C. Nardelli², G. Falconi³, E. Galossi³, H. Hajrullaj³, M. Crocioni², M. Quintini², A. Cristiano^1|5, P. Niscola⁶, M.P. Martelli², R. La Tagliata⁷, C. Mecucci², M.T. Voso³

¹ Department of Biomedicine and Prevention, PhD program in immunology, molecular medicine and applied biotechology, University of Tor Vergata

² Institute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital

³ Department of Biomedicine and Prevention, University of Tor Vergata

⁴ UniCamillus-Saint Camillus International University of Health Sciences

⁵ Operative Research Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico

⁶ Division of Haematology, Sant' Eugenio Hospital

⁷ Hematology, Belcolle Hospital, Italy

https://doi.org/10.3324/haematol.2026.s1.45

CO41 | Monocyte activation by CAR-T cells: role of extracellular vesicles and secretome in immune modulation (148 Online Views)

B. Xhahysa¹, M. Farina², I. Grossi³, L. Garuffo¹, R.M. Ferraro³, A. Leoni¹, A. Cavalleri¹, S. Mutti¹, F. Trenta¹, F. Re¹, E. Morello², D. Avenoso^1|2, P. Balzarini³, A. Salvi³, M. Malagola^1|2, D. Russo^1|2, S. Bernardi¹

¹ Department of Clinical and Experimental Sciences, University of Brescia

² Unit of Blood Diseases and BMT, ASST Spedali Civili of Brescia

³ Department of Molecular and Translational Medicine, University of Brescia, Italy

https://doi.org/10.3324/haematol.2026.s1.46

CO42 | Dynamic changes after allogeneic stem cell transplantation of extracellular vesicles originated from platelets, endothelial cells and leukocytes after: correlation with acute graft-versus-host disease (111 Online Views)

¹ Stem Cell Transplant Program, Department of Oncology, A. O. U. Città della Salute e della Scienza di Torino

² Department of Molecular Biotechnology and Health Sciences, University of Torino

³ Clinical Epidemiology, A. O. U. Città della Salute e della Scienza di Torino

⁴ University Hospital A. O. U. "Città della Salute e della Scienza di Torino", Division of Hematology

https://doi.org/10.3324/haematol.2026.s1.47

CO43 | Fourier-transform infrared spectroscopy of plasma as a liquid biopsy for monitoring acute myeloid leukemia and extramedullary relapse following allo-HSCT (106 Online Views)

¹ Centro di Ricerca Emato-oncologico AIL, ASST Spedali Civili di Brescia

² Unit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia

³ Department of Medical and Surgical Specialties, Radiological Sciences and Public Health - DSMC, University of Brescia

⁴ Center for Colloid and Surface Science -CSGI- Sesto Fiorentino

https://doi.org/10.3324/haematol.2026.s1.48

CO45 | Targeting IDO1 and ATP catabolism overcomes the tolerogenic effects of cytarabine on acute myeloid leukemia immune microenvironment (111 Online Views)

D. Ocadlikova¹, P. Portararo², E. Adinolfi³, E. De Marchi³, A. Pegoraro³, E. Orioli³, S. Sangaletti², A. Curti¹

¹ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

² Fondazione IRCCS, Istituto Nazionale dei Tumori

³ Department of Medical Sciences, University of Ferrara, Italy

https://doi.org/10.3324/haematol.2026.s1.49

CO46 | BCR-ABL1 and JAK2v617f mutations in mesoangiogenic progenitor cells suggest a common bone marrow precursor for hematopoietic and stromal cell niche (108 Online Views)

I.S. Burzi¹, M. Montali², S. Barachini², E. Pardini¹, G. S. Infirri¹, D. Tagliafierro¹, A. Brunetti², A. Votto², L. Sijoni², R. Fazzi³, S. Galimberti², V. Susini¹, M. Franzini¹, I. Petrini¹

¹ Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Università di Pisa

² Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa

³ U. O. Ematologia, A. O. U. Pisana, Italy

https://doi.org/10.3324/haematol.2026.s1.50

CO47 | Exploring the role and cellular origin of extracellular vesicles as biomarkers in CAR-T cell therapy (110 Online Views)

G. Lia^1|2|3|4, M. Dicataldo^1|2|3|4, A. Melis^1|2|3|4, F. Ferrando^1|2|3|4, I. Dogliotti^2|3|4, A. Busca^2|3|4, S. Ragaini¹, V. Granero, B. Botto⁵, M. Clerico⁶, M. Novo⁵, F. Cavallo⁷, L. Giaccone⁷, B. Bruno⁷

¹ Department of Molecular Biotechnology and Health Sciences, University of Torino

² Stem Cell Transplant Program, AOU Città della Salute e della Scienza di Torino

³ 3 Blood Bank, Immunohaematology and Transfusion Medicine Center

⁴ A. O. U. Città della Salute e della Scienza di Torino

⁵ Division of Hematology, AOU Città della Salute e della Scienza di Torino

⁶ Division of Hematology U, A. O. U. Città della Salute e della Scienza di Torino

⁷ Division of Hematology U, Department of Molecular Biotechnology and Health Sciences, University of Torino

https://doi.org/10.3324/haematol.2026.s1.51

CO48 | Patient specific ipscs-derived sinusoidal endothelial cells for phenotypic correction of haemophilia a (39 Online Views)

A. Benetti¹, C.M. Radu¹, M. Trevisan², C. Samà¹, C. Simion¹, E. Campello¹, P. Simioni¹

¹ Department of Medicine, Clinical Medicine 1, Padua University Hospital

² Department of Molecular Medicine, University of Padua, Padua, Italy

CO49 | Combined nf1/suz12 haploinsufficiency drives aberrant activation of the RAS signaling cascade in immature hoxa-positive T-ALL (115 Online Views)

¹ Hematology and Bone Marrow Transplantation Unit, Department of Medicine and Surgery, University of Perugia

² {2}Department of Medicine and Surgery, University of Parma, Parma, Italy

³ Hematology and BMT Unit, Azienda Ospedaliero Universitaria di Parma, Parma, Italy, Translational Hematology and Chemogenomics, University of Parma

⁴ {3}Laboratory of Molecular Medicine and Cytogenetics. Hematology Unit, CREO, Azienda Ospedaliera di Perugia

⁵ {4}Dipartimento di Scienze di Laboratorio ed Ematologiche-Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore

⁶ {5}Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Turin

⁷ {6}Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele

⁸ {7}Hematology and Stem Cell Transplantation Unit, AOUC Policlinico of Bari

⁹ {8}Hematology and BMT Unit, Azienda Ospedaliero-Universitaria di Parma

¹⁰ {9}Hematology Unit, Hospital 'Antonio Cardarelli'

¹¹ {10}Hematology Clinic, Azienda Ospedaliero Universitaria delle Marche

¹² {11}Section of Hematology, Department of Oncology and Hematology. Azienda Ospedaliero-Universitaria di Modena

¹³ {12}University of Piemonte Orientale

¹⁴ {13}Division of Hematology, Foundation, IRCCS Policlinico San Matteo, Pavia

¹⁵ {14}SOD Hematology, University of Florence, AOU Careggi

¹⁶ {15}Hematology, Department of Biotecnologie Cellulari ed Ematologia, Sapienza, University of Rome

¹⁷ {16}Division of Medical Genetics, Department of Experimental Medicine, San Camillo-Forlanini Hospital, Sapienza University

https://doi.org/10.3324/haematol.2026.s1.52

CO50 | Redefining FLT3 in B-ALL novel findings and therapeutic outlook (101 Online Views)

A. Ferrari¹, F. L. Schiavo¹, C. Salvesi¹, L. Ledda¹, M. Paganelli¹, A. Spedaluzzi¹, M. C. Papayannidis², G. Marconi³, M. Rondoni⁴, A.. Mianulli⁵, B. Giannini⁶, C. Pasciolla⁷, F. Giglio⁸, S. Galimberti⁹, M. Fumagalli¹⁰, P. Salutari¹¹, V. Gaidano¹², M.. Giannini¹³, A. Imovilli¹⁴, E. Mauro¹⁵, E. Fonzi¹⁶, A. G. L. Di Rorà¹⁷, G. Martinelli¹⁸, G. Simonetti¹

¹ Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori - IRST "Dino Amadori"

² IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

³ University of Bologna, Hematology Unit, S. Maria delle Croci hospital

⁴ Hematology Unit & Romagna Transplant Network, S. Maria delle Croci hospital

⁵ Hematology, Infermi Hospital

⁶ U. O. Genetica Medica, Laboratorio Unico- AUSL della Romagna, Italy

⁷ Hematology and Bone Marrow Transplantation Unit, Istituto Oncologico IRCCS “Giovanni Paolo II”

⁸ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute

⁹ Hematology Unit, AOUP Santa Chiara

¹⁰ Hematology Unit, Ospedale San Gerardo

¹¹ Dipartimento Oncologia Ematologia, Ospedale Civile Santo Spirito

¹² SCDU Ematologia e Terapie cellulari, A. O. Ordine Mauriziano

¹³ Hematology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori

¹⁴ Hematology, Azienda USL-IRCCS Reggio Emilia, Emilia-Romagna, Italy

¹⁵ UOC Ematologia Ospedale Ca' Foncello Azienda ULSS 2 Marca Trevigiana

¹⁶ Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori

¹⁷ Fondazione Pisana per la Scienza ONLUS

¹⁸ University of Bologna, Istituto di Ematologia “Seràgnoli”

https://doi.org/10.3324/haematol.2026.s1.53

CO51 | Pediatric PAX5-rearranged acute lymphoblastic leukemia is a high-risk molecular subgroup of B-ALL with a poor MRD-dependent prognostic profile (91 Online Views)

¹ Pediatrics, Fondazione IRCCS San Gerardo dei Tintori

² Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori

³ School of Medicine and Surgery, University of Milano-Bicocca

⁴ Department of Human Genetics, Hannover Medical School

⁵ Clinical Genetics and Genomic Medicine, University Hospital Würzburg

⁶ Department for Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine University

⁷ Department of Paediatric Haematology and Oncology, Hannover Medical School

⁸ St. Anna Children's Cancer Research Institute

⁹ Labdia Labordiagnostik

¹⁰ Unit of Hematology, IRCCS Istituto Giannina Gaslini

¹¹ Pediatric Hematology Oncology, Azienda Policlinico "G. Rodolico"

¹² Dept. Oncology, Hematology and Cell Therapy, AORN, Santobono-Pausilipon

¹³ Istituto di Ricerca Pediatrica-Città della Speranza, Pediatric Onco-Hematology, Stem Cell Transplant and Gene Therapy Laboratory

¹⁴ Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù

¹⁵ Department of Pediatrics, Catholic University of the Sacred Heart

¹⁶ University Medical Center Schleswig-Holstein- Campus Kiel, Department of Pediatrics- Berlin-Frankfurt-Münster ALL Study Group Germany BFM-G

¹⁷ Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital

https://doi.org/10.3324/haematol.2026.s1.54

CO52 | Deciphering the crosstalk between stroma and acute myeloid leukemia cells: an in vitro model to uncover the mechanisms underlying extramedullary progression in acute myeloid leukemia (103 Online Views)

G. Silvestrini¹, N. Lelli¹, S. Masciarelli², G. Mazzanti², F. Liccardo², L. Guarnera³, M. Divona^1|4, P. Ricci¹, M.. I. Consalvo¹, G. Colafranceschi¹, S. Gargiulo¹, F. Fazi², T. Ottone^1|5, a. M.. Voso^1|5

¹ Department of Biomedicine and Prevention, Tor Vergata University

² Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome

³ Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata

⁴ Saint Camillus International University of Health Sciences

⁵ Santa Lucia Foundation, IRCCS, Neuro-Oncohematology, Italy

https://doi.org/10.3324/haematol.2026.s1.55

CO53 | Targeting the PA2G4-NPM1 axis triggers nucleolar stress in NPM1c acute myeloid leukemia (101 Online Views)

E. Simoncini¹, R. Zamponi², A. Montanaro¹, R.M. P. A. Patarino¹, F. Vento¹, A. Gherli¹, V. Marinoni¹, B. Lorusso¹, R. Rosati¹, G. Monica¹, R. Castelli³, A. Andolfo⁴, C. Braccia⁴, A. Lodola³, G. Roti^1|2

¹ Department of Medicine and Surgery, University of Parma

² Hematology and BMT Unit, Azienda Ospedaliero-Universitaria di Parma

³ Department of Food and Drug, University of Parma

⁴ ProMeFa, Proteomics and Metabolomics Facility, Center for Omics Sciences, IRCCS San Raffaele Scientific Institute

https://doi.org/10.3324/haematol.2026.s1.56

CO54 | Biallelic loss of RB1 and LPAR6 at 13q14 drives key cell cycle abnormalities in T-cell acute lymphoblastic leukemia (134 Online Views)

F. Servoli¹, M. Giaimo^2|3|4, V. Pierini⁵, V. Bardelli¹, S. Arniani¹, M. Lucarelli¹, C. Matteucci¹, B. Crescenzi⁵, S. Romoli⁵, L. Pagliaro^2|3|4, R. Zamponi^2|3|4, A. Fiou⁶, M. Vecchi⁷, F. Landuzzi⁶, F. Forghieri⁸, A. Curti⁹, B. Cambò^2|3|4, C. Pasciolla¹⁰, F. Lessi¹¹, F. Lussana¹², A. Cavalli^6|13|14, G. Roti^2|3|4, M.P. Martelli¹, R. La Starza¹

¹ Hematology and Bone Marrow Transplantation Unit, Department of Medicine and Surgery, University of Perugia

² Department of Medicine and Surgery, University of Parma

³ Hematology and BMT Unit, Azienda Ospedaliero Universitaria di Parma

⁴ Translational Hematology and Chemogenomics

⁵ Laboratory of Molecular Medicine and Cytogenetics. Hematology Unit, CREO, Azienda Ospedaliera di Perugia

⁶ Center for Clinical and Computational Genomics, Computational and Chemical Biology, Fondazione Istituto Italiano di Tecnologia

⁷ Center for Clinical and Computational Genomics, Non-coding RNAs and RNA-based therapeutics, Fondazione Istituto Italiano di Tecnologia

⁸ Section of Hematology, Department of Oncology and Hematology. Azienda Ospedaliero-Universitaria di Modena

⁹ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

¹⁰ Hematology Unit, IRCCS Istituto Tumori "Giovanni Paolo II"

¹¹ Department of Medicine, Hematology and Clinical Immunology Unit, University of Padova

¹² Department of Oncology and Hematology, University of Milan and Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII

¹³ Center for Human Technologies, Computational and Chemical Biology, Fondazione Istituto Italiano di Tecnologia

¹⁴ Centre Européen de Calcul Atomique et Moléculaire

https://doi.org/10.3324/haematol.2026.s1.57

CO55 | Integrating NGS and optical genome mapping to improve genomic characterization of adult BCR:ABL1-negative B-ALL (100 Online Views)

L. Bonamici¹, B. Conte¹, E. Sbadili¹, G. Fera¹, C. Meli², G. Debbia¹, P. Barozzi¹, A. Paolini³, S. Martinelli³, M. Morselli¹, L. Potenza¹, D. Giusti¹, E. Colaci¹, F. Bettelli¹, P. Bresciani¹, A. Cuoghi¹, A. Gilioli¹, A. Messerotti¹, V. Pioli¹, R. Manfredini⁴, F. Forghieri¹, M. Luppi¹, F. Lussana², O. Spinelli⁵, R. Maffei³, A. Rambaldi², E. Tagliafico³

¹ Hematology Unit, and Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria, Policlinico

² Department of Oncology and Hematology, University of Milan and ASST Papa Giovanni XXIII

³ Department of Laboratory Medicine and Pathology, Diagnostic Hematology and Clinical Genomics, Azienda Ospedaliero-Universitaria, Policlinico

⁴ Interdepartmental Centre for Stem Cells and Regenerative Medicine and Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia

⁵ Department of Oncology and Hematology, ASST Papa Giovanni XXIII

https://doi.org/10.3324/haematol.2026.s1.58

CO56 | Integration of multiple RNA-seq datasets enhances deep profiling of NPM1-mutated FLT3-ITD-negative acute myeloid leukemia (141 Online Views)

M. Caridi^1|2, G. Cimino³, W. Villiers⁴, M. Lim⁴, F. Milano³, S. De Santis³, R. Ranieri³, V. Cardinali³, P. Aucken⁴, R. Dillon⁴, M.P. Martelli³

¹ Hematology Unit, Belcolle Hospital

² Department of Physiology and Pharmacology, Sapienza University of Rome

³ Division of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy

⁴ Department of Medical and Molecular Genetics, King’s College London, UK

https://doi.org/10.3324/haematol.2026.s1.59

CO57 | Molecular characterization of a cohort of patients with polycythemia vera: a single-center study (110 Online Views)

E. Nacca¹, C. Ghetti¹, F. Vanderwert¹, V. Boldrini¹, L. Fagiolo¹, G. Rotunno¹, L. Signori¹, C. Basile¹, F. Gesullo¹, A. Enderti¹, A.. Vannucchi¹, P. Guglielmelli¹

¹ Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative - CRIMM, AOU Careggi, University of Florence, Italy

https://doi.org/10.3324/haematol.2026.s1.60

CO58 | Single-cell multi-omics unravels molecular and cellular programs underlying ruxolitinib response in myelofibrosis (122 Online Views)

¹ Interdepartmental Centre for Stem Cells and Regenerative Medicine, University of Modena and Reggio Emilia

² Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia

³ Department of Life Sciences, University of Modena and Reggio Emilia

⁴ Department Oncology and Hematology, Hematology Unit, Modena University Hospital

⁵ CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, University of Florence

⁶ Department of Experimental and Clinical Medicine, University of Florence

⁷ Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia

⁸ Department of Laboratory Medicine, Diagnostic Hematology and Clinical Genomics Unit, Modena University Hospital

https://doi.org/10.3324/haematol.2026.s1.61

CO59 | JAK2 46/1 haplotype and JAK2 variant allelic frequency correlate with the development of polycythemic phenotype in JAK2-mutated essential thrombocytemia patients (133 Online Views)

¹ CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, University of Florence

² Department of Experimental and Clinical Medicine, University of Florence

³ FROM Ospedale Papa Giovanni XXIII

https://doi.org/10.3324/haematol.2026.s1.62

CO60 | One hundred suspected myeloproliferative neoplasms with a JAK2 v617f variant allele frequency <2%: clinical, genetic and histopathological correlates (145 Online Views)

G.G. Loscocco¹, R. Santi², G. Rotunno¹, L. Signori¹, F. Gesullo¹, F. Pancani¹, C. Maccari¹, V. Boldrini¹, P. Guglielmelli¹, U. Gianelli³, A.M. Vannucchi¹

¹ Department of Experimental and Clinical Medicine, CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, University of Florence

² Hemopathology Unit, AOU Careggi, University of Florence

³ Pathology Unit, ASST Santi Paolo e Carlo, University of Milan

https://doi.org/10.3324/haematol.2026.s1.63

CO61 | Transcriptomic analysis of CD34⁺ cells in myelofibrosis highlights their role in extracellular matrix dysregulation and marrow fibrosis (111 Online Views)

S. Bernardi¹, L. Garuffo¹, M. Farina¹, G. Pozzi², L. M. Pasini³, S. Cortellazzi², A. Leoni¹, O. Di Martino², F. Arciprete⁴, M. Zingariello⁴, M. Vitale⁵, D. Russo¹, C. Carubbi², E. Masselli^2|3

¹ Department of Clinical and Experimental Sciences, University of Brescia, Unit of Cell Therapy and Bone Marrow Transplantation, ASST Spedali Civili of Brescia

² Department of Medicine and Surgery, Anatomy Unit, University of Parma

³ Hematology and BMT Unit, Parma University Hospital

⁴ Laboratory of Microscopic and Ultrastructural Anatomy, Campus Bio-Medico University of Roma

⁵ Faculty of Medicine, Vita-Salute University-San Raffaele, Italy

https://doi.org/10.3324/haematol.2026.s1.64

CO62 | CD9 defines the disease-propagating hematopoietic stem cell population in myelofibrosis (123 Online Views)

¹ CIDSTEM, Interdepartmental Centre for Stem Cells and Regenerative Medicine, University of Modena and Reggio Emilia

² Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia

³ Department of Life Sciences, University of Modena and Reggio Emilia

⁴ Department of Laboratory Medicine and Pathology, Diagnostic Hematology and clinical Genomics Unit, Modena University Hospital

⁵ Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia

⁶ CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, University of Florence

⁷ Department of Experimental and Clinical Medicine, University of Florence

⁸ Department of Laboratory Medicine, Diagnostic Hematology and Clinical Genomics Unit, Modena University Hospital

https://doi.org/10.3324/haematol.2026.s1.65

CO63 | abcg2 and havcr2 SPNs are associated with long-term TFR maintenance in chronic myeloid leukemia patients (117 Online Views)

¹ Division of Hematology and Bone Marrow Transplant, Azienda Sanitaria Universitaria Friuli Centrale

² Department of Medicine, University of Udine

³ Hematology Unit, Azienda Sanitaria Friuli Occidentale

⁴ Hematology Unit, Azienda Sanitaria Universitaria Giuliano-Isontina

⁵ Department of Medical, Surgical and Health Sciences, University of Trieste

https://doi.org/10.3324/haematol.2026.s1.66

CO64 | Dissecting the role of CCL2/CCR2 axis in myelofibrosis: translational evidence from murine models to human cells (121 Online Views)

L.M. Pasini¹, G. Pozzi², O. Di Martino², S. Cortellazzi², R. Vairo², C. Micheloni², F. Arciprete³, M. Zingariello³, S. Bernardi⁴, A.R. Migliaccio^5|6, M. Vitale⁷, C. Carubbi², E. Masselli^1|2

¹ Parma University Hospital, Hematology and BMT Unit

² Department of Medicine and Surgery, University of Parma

³ Campus Bio-Medico University of Rome

⁴ Department of Clinical and Experimental Sciences, University of Brescia

⁵ Altius Institute for Biomedical Sciences

⁶ Nanotec-CNR Nanotec-CNR

⁷ Faculty of Medicine, Vita-Salute University-San Raffaele, Italy

https://doi.org/10.3324/haematol.2026.s1.67

CO65 | Clinical impact of untargeted baseline plasma metabolomics in newly diagnosed diffuse large B-cell lymphoma (101 Online Views)

M. Almasri¹, R. Dondolin¹, D. Marradi², E. Barberis², L. T. Di Bergamo³, C. Cosentino¹, A. Bruscaggin³, M. Salehi³, R. Bruna¹, M. Bellia¹, M. Schipani¹, J. Nabki¹, B. A. Deeban¹, L. Cividini¹, S. Mouhssine¹, N. Maher¹, J. Ghanej¹, F. Maiellaro¹, A. andorno⁴, F. Mercalli⁴, E. Martino⁵, A.M. Mahmoud¹, W. A. Essa¹, N. M. Diop¹, E. Secomandi¹, C. Deambrogi¹, S. Rasi¹, R. L. Boldorini⁴, M. Gentile⁵, G.A. Palumbo⁶, V. Gattei⁷, R. Foà⁸, D. Rossi³, M. Manfredi², G. Gaidano¹, R. Moia¹

¹ Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

² Center for Translational Research on Autoimmune and Allergic Diseases CAAD, University of Piemonte Orientale

³ Laboratory of Experimental Hematology, Institute of Oncology Research

⁴ Division of Pathology, Department of Health Sciences, Università del Piemonte Orientale

⁵ Hematology Unit AO of Cosenza

⁶ Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G. F. Ingrassia", University of Catania

⁷ Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano CRO IRCCS

⁸ Hematology, Department of Translational and Precision Medicine, ‘Sapienza’ University

https://doi.org/10.3324/haematol.2026.s1.68

CO67 | Secondary genetic events and their relationship to TP53 mutation in mantle cell lymphoma. A sub-study from the Fondazione Italiana Linfomi Mantle First-BIO study (109 Online Views)

M.E. Carazzolo^1|2, F.M. Quaglia³, A. Aparo², A. Moioli³, A. Parisi⁴, R. Moia⁵, F. Piazza⁶, A. Re⁷, M.C. Tisi⁸, L. Nassi⁹, P. Bulian¹⁰, A. Castellino¹¹, V.R. Zilioli¹², P.M. Stefani¹³, A. Fabbri¹⁴, E. Lucchini¹⁵, A. Arcari¹⁶, L. Lorenzi¹⁷, B. Famengo¹⁸, M. Ponzoni¹⁹, A. Ferrari²⁰, S. Ragaini²¹, J. Olivieri²², V. Salaorni²³, S. Gambino^3|24, M. Galasso^3|24, M.T. Scupoli^2|24, C. Visco^3|24

¹ Department of Medicine, University of Verona

² Research Center LURM Interdepartmental Laboratory of Medical Research, University of Verona

³ UOC di Ematologia, DAI Medico Generale, AOUI Verona

⁴ Department of Pathology and Diagnostics, University Hospital of Verona

⁵ Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale and AOU Maggiore della Carità di Novara

⁶ Department of Medicine, University of Padova and Unit of Hematology, Azienda Ospedale Università Padova

⁷ UOC Ematologia, Spedali Civili di Brescia

⁸ Hematology Unit, San Bortolo Hospital, Vicenza

⁹ Hematology, Careggi Hospital and University of Florence

¹⁰ Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano, Istituto di Ricovero e Cura a Carattere Scientifico

¹¹ Hematology Unit, AO Santa Croce e Carle, Cuneo

¹² Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan

¹³ Struttura Complessa di Ematologia, Dipartimento Strutturale di Medicina Interna. Presidio Ospedaliero di Treviso

¹⁴ UOC Ematologia, Azienda Ospedaliero-Universitaria Senese

¹⁵ UCO Ematologia, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste

¹⁶ Unità Operativa Complessa di Ematologia, Azienda USL di Piacenza, Ospedale Guglielmo da Saliceto, Piacenza

¹⁷ Department of Histopathology, University of Brescia, ASST Spedali Civili di Brescia

¹⁸ Pathology Department, San Bortolo Hospital

¹⁹ Vita Salute San Raffaele University and Pathology Unit, San Raffaele Hospital Scientific Institute, Milan

²⁰ Hematology, Azienda USL-IRCCS di Reggio Emilia

²¹ Division of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino

²² Hematology Clinic, ASUFC Udine

²³ Department of Diagnostic and Public Health, University of Verona

²⁴ Department of Engineering for Innovation Medicine, Section of Biomedicine, University of Verona

https://doi.org/10.3324/haematol.2026.s1.69

CO68 | Genomic analyses of patients with mantle cell lymphoma that were refractory or relapsed after induction therapy: results from the Fondazione Italiana Linfomi Mantle First-BIO study (93 Online Views)

F.M. Quaglia¹, M.E. Carazzolo², A. Aparo³, A. Parisi⁴, R. Moia⁵, F. Piazza⁶, A. Re⁷, M.C. Tisi⁸, L. Nassi⁹, P. Bullian¹⁰, A. Castellino¹¹, V.R. Zilioli¹², P.M. Stefani¹³, A. Fabbri¹⁴, F. Zaja¹⁵, A. Arcari¹⁶, L. Lorenzi¹⁷, B. Famengo¹⁸, M. Ponzoni¹⁹, A. Ferrari²⁰, S. Ferrero²¹, J. Olivieri²², M.T. Scupoli^3|23, V. Salaorni²⁴, S. Gambino²³, M. Galasso²³, C. Visco²³

¹ UOC di Ematologia, DAI Medico Generale, AOUI Verona

² Department of Medicine, University of Verona

³ Research Center LURM Interdepartmental Laboratory of Medical Research, University of Verona

⁴ Department of Pathology and Diagnostics, University Hospital of Verona

⁵ Università del Piemonte Orientale

⁶ Hematology Division, Department of Medicine, University of Padova

⁷ UOC Ematologia, Spedali Civili di Brescia

⁸ Hematology Unit, San Bortolo Hospital

⁹ Hematology Unit, Careggi University Hospital

¹⁰ Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano, Istituto di Ricovero e Cura a Carattere Scientifico

¹¹ Hematology Unit, Santa Croce E Carle Hospital

¹² Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano

¹³ Struttura Complessa di Ematologia, Dipartimento Strutturale di Medicina Interna. Presidio Ospedaliero di Treviso

¹⁴ Unit of Hematology, Azienda Ospedaliera Universitaria Senese and University of Siena

¹⁵ Department of Medical, Surgical and Health Sciences, University of Trieste

¹⁶ Unità Operativa di Ematologia, Ospedale Guglielmo da Saliceto

¹⁷ Department of Histopathology, University of Brescia, ASST Spedali Civili di Brescia

¹⁸ Pathology Department, San Bortolo Hospital

¹⁹ Ospedale S. Raffaele H. Scientific Institute

²⁰ Hematology, Azienda USL-IRCCS di Reggio Emilia

²¹ Division of Hematology, Department of Molecular Biotechnology and Health Sciences, University of Torino

²² Hematology Clinic, ASUFC Udine

²³ Department of Engineering for Innovation Medicine, Section of Biomedicine, University of Verona

²⁴ Department of Diagnostic and Public Health, University of Verona

https://doi.org/10.3324/haematol.2026.s1.70

CO69 | PRDM1 and TNFAIP3 copy number losses predict a shorter time to first treatment in igm gammopathies: new insights from the Fondazione Italiana Linfomi “BIO-WM” trial (91 Online Views)

M. Pironti¹, S. Ferrero^1|2, S. Zimbellini³, L. Marcheselli⁴, S. Russo¹, E. Genuardi¹, C. Varraso³, F. Cavallo^1|2, I. Dogliotti², E. Cappello³, S. Ragaini¹, G. Favrin³, A. Ferrari⁵, M. Coscia⁶, C. Jimenez⁷, B. M. Granelli⁸, L. Laurenti⁹, E. Cencini¹⁰, S. Tommassetti¹¹, D. Marino¹², G. Loseto¹³, M. Marchetti¹⁴, F. Russo¹⁵, A. Sica¹⁶, J. Olivieri¹⁷, E. Amaducci¹, C. Picone³, B. Bruno^1|2, M. Varettoni³, D. Drandi¹

¹ Department of Molecular Biotechnology and health sciences, Hematology Division, University of Torino

² Division of Hematology, A. O. U. Città della Salute e della Scienza di Torino, Torino

³ Fondazione IRCCS Policlinico San Matteo

⁴ Fondazione Italiana Linfomi

⁵ Ematologia - AO Arcispedale Santa Maria Nuova - IRCCS

⁶ Department of Medicine and Surgery, University of Insubria and Division of Hematology ASST Sette Laghi

⁷ Haematology Department, University Hospital of Salamanca, Research Biomedical Institute of Salamanca CIBERONC and Center for Cancer Research-IBMCC

⁸ ASST Grande Ospedale Metropolitano Niguarda - SC Ematologia

⁹ Ematologia - Università Cattolica S. Cuore

¹⁰ U. O. C. Ematologia, AOU Senese

¹¹ Ematologia - Ospedale degli Infermi di Rimini

¹² Oncologia 1 - I. R. C. C. S. Istituto Oncologico Veneto

¹³ U. O. C Ematologia, IRCCS Istituto Tumori Giovanni Paolo II

¹⁴ S. O. S. Ematologia, Ospedale Cardinal Massaia

¹⁵ AOU di Parma - UOC Ematologia e CTMO

¹⁶ AOU Universitа degli Studi della Campania Luigi Vanvitelli - Oncologia Medica ed Ematologia

¹⁷ Azienda Sanitaria Universitaria Friuli Centrale - SOC Clinica Ematologica

https://doi.org/10.3324/haematol.2026.s1.71

CO70 | Comparative assessment of targeted next-generation sequencing panels and algorithms for optimal molecular subtyping of diffuse large B-cell lymphoma in clinical practice (104 Online Views)

D. Gallucci¹, M.C. Vegliante^2|3, G. Gargano⁴, A. Ferri¹, L. Pasini¹, S. Lonardi¹, G. Mandelli¹, D. Medicina¹, P. Balzarini¹, V. Pellegrini¹, W. Vermi¹, C. Re¹, P. Bossini¹, A. Sanzogni¹, E. Albertini¹, A. Tucci⁵, A. Re⁵, M. Pizzi⁶, A. Di Napoli⁷, F. Cordero⁸, L. Lorenzi¹, S. Ciavarella^2|3

¹ Anatomia Patologica, ASST Spedali Civili di Brescia e DMMT Università degli Studi di Brescia

² Hematology Hematology

³ and Cell Therapy Unit, IRCCS-Istituto Tumori "Giovanni Paolo II"

⁴ Dipartimento di Bioscienze, Biotecnologie e Ambiente, Università degli Studi di Bari Aldo Moro

⁵ Ematologia, ASST Spedali Civili di Brescia

⁶ Anatomia Patologica, Azienda Ospedaliera Universitaria di Padova

⁷ Dipartimento di Medicina Clinica e Molecolare, Ospedale Universitario Sant'Andrea, Sapienza Università di Roma

⁸ Dipartimento di Informatica, Università degli Studi di Torino

https://doi.org/10.3324/haematol.2026.s1.72

CO71 | HELLS-driven chromatin remodeling defines transcriptional programs and therapeutic vulnerabilities in ALK-negative anaplastic large cell lymphoma (141 Online Views)

G. Gambarelli^1|2, S. Mallia¹, N. Puccio¹, V. Manicardi¹, B. Donati¹, E. Vitale¹, M. Zanelli¹, S. Luminari¹, F. Merli¹, A. Neri¹, A. Ciarrocchi¹, V. Fragliasso¹

¹ Azienda USL-IRCCS di Reggio Emilia

² Università degli Studi di Modena e Reggio Emilia, Italy

https://doi.org/10.3324/haematol.2026.s1.73

CO72 | CK2 drives immune cell recruitment via cytokine modulation in Hodgkin lymphoma (304 Online Views)

A. Beltrame¹, P. Fantato¹, M. Castronuovo¹, G. Capasso¹, V. Gramegna¹, A. Cellini¹, F. Angotzi¹, A. Serafin¹, L. Trentin¹, F. Frezzato¹, A. Visentin¹

¹ Hematology Unit, Department of Medicine, University of Padua, Italy

https://doi.org/10.3324/haematol.2026.s1.74

P002 | Multi-omics analysis unravels new biomarkers of relapse risk in adult Philadelphia-positive B-ALL (104 Online Views)

R. Merlo^1|2, D. Cardinali³, F. Kaiser³, A. Caregari^1|2, S. Orsi^1|2, E. Roncaglia^1|2, S.H. Anjedani⁴, M. Beldinanzi³, S. Bresolin⁴, E. Gaffo¹, S. Chiaretti³, S. Bortoluzzi¹

¹ Computational Genomics Group, Department of Oncology, Surgery and Gastroenterology, University of Padua

² Department of Biology, University of Padua

³ Department of Translational and Precision Medicine, University of Roma "La Sapienza"

⁴ Pediatric hematology, oncology and hematopoietic cell & gene therapy, Pediatric Research Institute, Città della Speranza

https://doi.org/10.3324/haematol.2026.s1.75

P003 | Long-read RNA sequencing for investigating bortezomib resistance mechanisms in multiple myeloma cell lines (148 Online Views)

G.N. Conti¹, E. La Spina¹, L. Longhitano¹, J Ferrigno¹, S. Giallongo², A. Duminuco³, G.A. Palumbo³, I. Dulcamare⁴, C. Conticello⁵, S. Forte⁶, S.P. Lombardo¹, G. Chisari⁶, D. Cambria⁴, D. Calvo¹, M.E. G. Cantafio⁵, G. L. Volti¹, N. Amodio⁵, F. Di Raimondo⁴, A. Romano⁴, C. Giallongo¹, D. Tibullo¹

¹ Department of Biomedical and Biotechnological Sciences, University of Catania

² Faculty of Medicine and Surgery, University of Enna “Kore”

³ Department of Medical and Surgical Sciences and Advanced Technologies “G. F. Ingrassia”, University of Catania

⁴ Department of General Surgery and Medical-Surgical Specialties- University of Catania, Division of Haematology

⁵ Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro

⁶ Mediterranean Institute of Oncology

https://doi.org/10.3324/haematol.2026.s1.76

P004 | Genomic and functional characterization of the murine acute myeloid leukemia cell line c1498 as a preclinical model of venetoclax/azacitidine resistance (181 Online Views)

M. Ghetti¹, I. De Santis², D. Tolomeo³, F. Ruggieri^1|4, C. Bracci¹, M.T. Bochicchio¹, M. Paganelli¹, A. Ferrari¹, S. Sangaletti⁵, C. T. Storlazzi³, G. Simonetti¹

¹ Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori"

² Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori"

³ Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro

⁴ Department of Medical and Surgical Sciences DIMEC, University of Bologna

⁵ Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori

https://doi.org/10.3324/haematol.2026.s1.77

P005 | ASXL1 variant allele frequency as a modulator of genetic heterogeneity in myelofibrosis (121 Online Views)

G. Iaquinta¹, M. Breccia², P. Chiusolo³, A. Laganà², M. Santopietro⁴, M. Ragazzo¹, C. Cerroni¹, E. Rossi³, A. Tamburini⁵, S. C. Leonetti⁵, M. Rossi³, C. Tatarelli⁶, E. Abruzzese⁷, M. Trawinska⁷, R. Latagliata⁸, A. Andriani⁹, L. Maurillo¹⁰, L. Guarnera¹⁰, K. Paciaroni¹¹, P. Cercola¹², G. Pessina¹², V. De Stefano³, P. Grammatico¹

¹ Medical Genetics Experimental Medicine Department Sapienza University San Camillo-Forlanini Hospital

² Hematology Department of Translational and Precision Medicine Policlinico Umberto I Sapienza University

³ Institute of Hematology Catholic University

⁴ Hematology Department San Camillo-Forlanini Hospital

⁵ Hematology Department San Giovanni Hospital

⁶ Unit of Hematology Sapienza University Sant'Andrea Hospital

⁷ Sant'Eugenio Hospital Tor Vergata University

⁸ Hematology Department Belcolle Hospital

⁹ Hematology Department Nuovo Regina Margherita Hospital

¹⁰ Hematology Department AOU Policlinico Tor Vergata

¹¹ Hematology Department Santo Spirito Hospital

¹² Laboratory of Medical Genetics Santa Rosa Hospital

https://doi.org/10.3324/haematol.2026.s1.78

P006 | The IL8-CXCR1/CXCR2 axis plays a role in the mobilization process of polymorphonuclear myeloid-derived suppressor cells in patients with primary myelofibrosis (94 Online Views)

R. Campanelli¹, S. Mantovani², A. La Gaipa², C. Ramirez³, C. Abbà⁴, A. Carolei¹, P. Catarsi¹, C. Del Fante⁵, G. Barosi¹, M. Massa⁴, V. Rosti¹

¹ Center for the Study of Myelofibrosis, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia

² Department of Translational and Clinical Research, Laboratory of Clinical Immunology, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia

³ Laboratory of RNA and Disease Data Science, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento

⁴ General Medicine 2-Center for Systemic Amyloidosis and High-Complexity Disease, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia

⁵ Division of Immunohaematology and Transfusion Service, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia

https://doi.org/10.3324/haematol.2026.s1.79

P007 | Pre-clinical efficacy of a novel combined pharmacological approach targeting JAK and ERK in a myelofibrosis mouse model (104 Online Views)

¹ Interdepartmental Centre for Stem Cells and Regenerative Medicine, University of Modena and Reggio Emilia

² Department of Life Sciences, University of Modena and Reggio Emilia

³ Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia

⁴ Pathology Unit , Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia

⁵ CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi

⁶ Department of Experimental and Clinical Medicine, University of Florence

⁷ Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia

⁸ Department of Laboratory Medicine, Diagnostic Hematology and Clinical Genomics Unit, Modena University Hospital

https://doi.org/10.3324/haematol.2026.s1.80

P008 | JAK2E837K: a novel mutation post-polycythemia vera myelofibrosis (107 Online Views)

¹ IRCCS Santa Lucia Foundation

² Department of Biology and Biotechnology "Charles Darwin", University of Rome La Sapienza, Italy

³ Hematology Unit, S. Eugenio Hospital ASL Roma 2

⁴ Department of Medical and Surgical Sciences and Biotechnologies, University of Rome La Sapienza

⁵ Department of Health and Life Sciences, European University of Rome

⁶ Department of Medicine and Surgery, University of Parma

⁷ Department of Biomedicine and Prevention, Tor Vergata University

https://doi.org/10.3324/haematol.2026.s1.81

P009 | Beyond the Dynamic International Prognostic Scoring System: the role of inflammation in myelofibrosis (126 Online Views)

A. Votto¹, A. Duminuco², A. Brunetti¹, L. Sijoni¹, G. Lavenia³, G.A. Palumbo⁴, S. Galimberti¹

¹ UO di Ematologia, AOU Pisana, Ospedale Santa Chiara

² UO di Ematologia, AOU Policlinico “G. Rodolico”- San Marco

³ Scuola di Specializzazione in Ematologia - Università degli Studi di Catania

⁴ Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate “G. F. Ingrassia”, Università degli studi di Catania

https://doi.org/10.3324/haematol.2026.s1.82

P010 | Next generation sequencing in triple negative essential thrombocythemia: impact of additional mutations in risk assessment (112 Online Views)

¹ Division of Hematology and Bone Marrow Transplantation, Azienda Sanitaria Universitaria Friuli Centrale

² Department of Medicine - DMED, University of Udine

https://doi.org/10.3324/haematol.2026.s1.83

P011 | Metabolic rewiring fuels immunosuppression and fibrosis in myelofibrosis via the lactate–glutamate axis (147 Online Views)

G.A. Palumbo¹, C. Giallongo², S. Giallongo³, E. La Spina¹, L. Longhitano¹, A. Duminuco¹, J. Ferrigno², N. Conti², G. L. Volti², F. Bellia², A.M. Amorini², D. Calvo², A. Romano⁴, R. Caltabiano¹, G. Broggi¹, S. Lombardo², F. Di Raimondo⁴, D. Tibullo²

¹ Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G. F. Ingrassia", Università degli Studi di Catania

² Dipartimento di Scienze Biomediche e Biotecnologiche, Università degli Studi di Catania

³ Facoltà di Medicina e Chirurgia, Università di Enna "Kore"

⁴ Dipartimento di Chirurgia Generale e Specialità Medico-Chirurgiche, Università degli Studi di Catania

https://doi.org/10.3324/haematol.2026.s1.84

P014 | Azacitidine remodels hematopoietic stem/progenitor cell fate and restores erythroid differentiation in myelodysplastic/myeloproliferative neoplasms with neutrophilia via reactivation of the GATA switch (108 Online Views)

¹ Department of Medicine and Surgery, University of Milano-Bicocca

² Ematologia, Fondazione IRCCS San Gerardo dei Tintori

³ Neuroepigenetics Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute

⁴ Fondazione IRCCS San Gerardo dei Tintori, Italy

https://doi.org/10.3324/haematol.2026.s1.85

P015 | Filling the gaps: PEG-interferon in the under-treated world of systemic mastocytosis (135 Online Views)

A. Votto¹, I. Santo¹, A. Brunetti¹, L. Sijoni¹, M. D’amato¹, G. Bolognesi¹, I. Sorgiovanni¹, G. Volpe¹, C. Baratè¹, S. Galimberti¹

¹ Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa

https://doi.org/10.3324/haematol.2026.s1.86

P016 | A novel insight into the role of CCM genes in myeloproliferative neoplasms (93 Online Views)

C. Panuzzo¹, A. Bagherzadehsa¹, A. Ferrando¹, S. Rocco¹, A. Danzero¹, R. Vacca¹, B. Pergolizzi¹, C. Fava¹, F. Retta¹, D. Cilloni¹

¹ Università degli Studi di Torino, Dipartimento di Scienze Cliniche e Biologiche, Italy

https://doi.org/10.3324/haematol.2026.s1.87

P017 | The uncoupled NRF2-HMOX1 axis and persistent oxidative stress in myelofibrosis neutrophils, beyond JAK blockade (109 Online Views)

E. La Spina¹, C. Giallongo¹, L. Longhitano¹, S. Giallongo², A. Duminuco³, G. N. Conti¹, D. Calvo¹, J. Ferrigno¹, A.M. Amorini¹, G. L. Volti¹, A. Santisi³, A. Romano^4|5, F. Di Raimondo^4|5, A. Lucchesi⁶, G.A. Palumbo³, D. Tibullo¹

¹ Department of Biotechnological and Biomedical Sciences, University of Catania

² Department of Medicine and Surgery, University of Enna “Kore”

³ Department of Medical, Surgical Sciences and Advanced Technologies G. F. Ingrassia, University of Catania

⁴ Department of General Surgery and Medical-Surgical Specialties, University of Catania

⁵ Division of Hematology, Azienda Policlinico, University of Catania

⁶ Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" – IRST, Italy

https://doi.org/10.3324/haematol.2026.s1.88

P018 | Improving diagnostic standardization in myeloproliferative neoplasms: results from the Italian JakNet Program (114 Online Views)

¹ ¹Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative, AOU Careggi, University of Florence

² ²GIMEMA Foundation

³ ³Department of Medical and Surgical Sciences, Institute of Hematology "Lorenzo e Ariosto Seràgnoli", University of Bologna

⁴ ⁴Fondazione per la Ricerca Ospedale di Bergamo from Ente del Terzo Settore

⁵ ⁵Section of Hematology, Catholic University, Fondazione Policlinico Gemelli IRCCS

⁶ ⁶Pathology Unit, Department of Health Sciences, University of Milan and Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo

⁷ ⁷Università degli Studi di Napoli Federico II

⁸ ⁸Department of Medical, Surgical Sciences and Advanced Technologies "G. F. Ingrassia", Università degli Studi di Catania

⁹ ⁹Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan

¹⁰ ¹⁰Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy

https://doi.org/10.3324/haematol.2026.s1.89

P019 | Investigate the effect of momelotinib through high resolution ultrasound assessment of spleen stiffness and dimension measuraments: a real-life comparison with pivotal trials (97 Online Views)

A. Votto¹, S. Galimberti¹, A. Brunetti¹, L. Sijoni¹, M.C. Caparello¹, E. Benedetti¹

¹ Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa

https://doi.org/10.3324/haematol.2026.s1.90

P020 | Treatment-free remission attempts in chronic myeloid leukemia patients treated with second- and third-generation TKIs: a real-life experience (128 Online Views)

A. Votto¹, A. Brunetti¹, I. Santo¹, L. Sijoni¹, M. D’amato¹, G. Bolognesi¹, I. Sorgiovanni¹, C. Baratè¹, S. Galimberti¹

¹ Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa

https://doi.org/10.3324/haematol.2026.s1.91

P021 | Somatic testing for myeloproliferative neoplasms and re-analysis of sequence data in first-degree relatives allow the diagnosis of mpl-related autosomal dominant thrombocythemia: a benign condition or a precancerous disorder? (113 Online Views)

D. Guadagnolo^1|2, P. Cercola¹, M. L. Presti¹, S. Quattrociocchi¹, F. Rosetto¹, F. Natoni¹, R. Latagliata³, R. Laureana³, A. Diveroli³, S. Proietti¹, S. Ciucciarelli¹, M. Tonizza¹, G. Pessina¹

¹ UOSD Laboratorio Genetica Medica, Ospedale S. Rosa, ASL Viterbo

² Department of Molecular Medicine, Sapienza University of Rome

³ UOC Ematologia, Ospedale S. Rosa, ASL Viterbo

https://doi.org/10.3324/haematol.2026.s1.92

P022 | Fourier-transform infrared spectroscopy analysis of plasma-derived extracellular vesicles as a tool to detect TKI-related toxicity in chronic myeloid leukemia patients: a preliminary study (91 Online Views)

¹ University of Brescia, Department of Clinical and Experimental Sciences

² ASST Spedali Civili di Brescia, Unit of Blood Diseases and Bone Marrow Transplant

³ Hematology Unit, Department of Medicine, Surgery and Neuroscience, Azienda Ospedaliera Universitaria Senese, University of Siena, Italy

https://doi.org/10.3324/haematol.2026.s1.93

P023 | SETD2 loss in chronic myeloid leukemia promotes metabolic reprogramming and genomic instability leading to therapeutic resistance and disease progression (108 Online Views)

M. Mancini^1|2, L. Romagnoli², S. De Santis², S. Bruno², A. Tagliavia², C. Mosca², A. Oldani¹, A. Merlotti³, D. Remondini³, E. Esposito⁴, J. Fiori⁴, F. Castagnetti^1|2, M. Iezza², R. Restuccia², M. Lasala², A. Iurlo⁵, M Cerrano⁶, S. Galimberti⁷, P. L. Zinzani^1|2, S. Soverini¹

¹ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

² Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna

³ Department of Physics and Astronomy "DIFA", Università di Bologna

⁴ Dipartimento di Chimica "Giacomo Ciamician", Università di Bologna

⁵ UO Onco-ematologia, Fondazione IRCCS Ca' Granda - Ospedale Policlinico

⁶ A. O. U. Citta della Salute e della Scienza di Torino

⁷ Clinical and Experimental Medicine, Hematology, University of Pisa

https://doi.org/10.3324/haematol.2026.s1.94

P024 | Inflammatory and epigenetic mechanisms driving chronic myeloid leukemia: advances from the ‘Stem CML Cure’ project (136 Online Views)

C. Bono^1|2, F. Guerrini¹, A. Votto¹, A. Brunetti¹, I. Santo¹, L. Sijoni¹, L. Trombello¹, A. Sicuranza³, M. Bocchia^3|4, S. Galimberti^1|2

¹ Università di Pisa

² Azienda Ospedaliera Universitaria Pisana

³ Università di Siena

⁴ Azienda Ospedaliero-universitaria Senese

https://doi.org/10.3324/haematol.2026.s1.95

P025 | PD-L1 expression on PB CD26+ LSCs on chronic myeloid leukemia patients at diagnosis: role and implications (99 Online Views)

E. Pacini¹, A. Sicuranza¹, P. Pacelli¹, S. Galimberti², C. Bono², F. Guerrini², E. Abruzzese³, M. Crugnola⁴, V. Giai⁵, C. Fava⁶, I. Capodanno⁷, F. Sorà⁸, D. Cattaneo⁹, A. Iurlo⁹, F. Muriano¹⁰, E. Bestoso¹, G. Beffa¹, K. Peccia¹, M. Bocchia¹, D. Raspadori¹

¹ Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena

² Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa

³ Sant'Eugenio Hospital, Tor Vergata University

⁴ Ematologia e Centro BMT, Azienda Ospedaliero-Universitaria di Parma

⁵ Division of Hematology, Città Della Salute e Della Scienza, Turin

⁶ A. O. Ordine Mauriziano di Torino, Turin

⁷ SOC Ematologia Azienda USL-IRCSS di Reggio Emilia, Reggio Emilia

⁸ Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore

⁹ Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico

¹⁰ Hematology - Department of Clinical Medicine and Surgery, Federico II University, Naples

https://doi.org/10.3324/haematol.2026.s1.96

P026 | Tracking residual chronic myeloid leukemia: complementary insights from CD26⁺ stem cells and extracellular BCR::ABL1 (112 Online Views)

¹ Department of Clinical and Experimental Sciences, Università di Brescia - Unit of Blood Diseases and Bone Marrow Transplant, ASST Spedali Civili

² Centro di Ricerca Emato-Oncologica AIL, CREA, ASST Spedali Civili

³ University of Siena, Azienda Ospedaliera Universitaria

⁴ Umberto I Policlinico, La Sapienza University

⁵ Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Università di Brescia

⁶ Department of Molecular and Translational Medicine, Università di Brescia

⁷ IRCCS Fondazione Don Carlo Gnocchi ONLUS

⁸ Hematology, S. Eugenio Hospital, ASLRoma2

⁹ National Center for Gene Therapy and Drugs based on RNA Technology

https://doi.org/10.3324/haematol.2026.s1.97

P027 | Spalt-like transcription factor 4 deregulation in low risk myelodysplastic syndrome SF3B1-mutated patients (110 Online Views)

E. Lumia¹, E. Fabiani^2|3, H. Hajrullaj², S. Bianculli², E. Ricci², A. Cristiano^1|4, L. Guarnera¹, G. Falconi², M.T. Voso²

¹ Department of Biomedicine and Prevention, PhD program in immunology, molecular medicine and applied biotechology, University of Tor Vergata

² Department of Biomedicine and Prevention, University of Tor Vergata

³ UniCamillus-Saint Camillus International University of Health Sciences

⁴ Operative Research Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico

https://doi.org/10.3324/haematol.2026.s1.98

P028 | Flow cytometric characterization of myelodysplastic syndrome stem cells: a new prognostic tool (106 Online Views)

A. Sicuranza¹, P. Pacelli¹, A. Santoni¹, M. Cuccaro¹, T. Miracapillo¹, A. Zannoli¹, M. Bello¹, C. Carrara¹, D. Raspadori¹, C. Z. Brambilla¹, M. Bocchia¹

¹ Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy

https://doi.org/10.3324/haematol.2026.s1.99

P029 | Sex-based differential DNA methylation signatures in myelodysplastic neoplasms (110 Online Views)

S. De Pourcq¹, G. Mattiuz¹, E. Celoni¹, M. Raddi^1|2, G. andreossi¹, C. Amato¹, B. Caciagli¹, L. Rigodanza¹, A. Consagra¹, V. Santini¹

¹ MDS Unit, Hematology, AOU Careggi, University of Florence, Department of Experimental and Clinical Medicine

² University of Siena, Department of Medical Biotechnologies, Siena

https://doi.org/10.3324/haematol.2026.s1.100

P030 | Imetelstat restores erythroid maturation in responding low risk myelodysplastic disorders patients (477 Online Views)

M.G. Raddi^1|2, S. Bencini³, G. Mattiuz¹, S. Depourcq¹, A. Consagra¹, L. Rigodanza⁴, G. andreossi⁴, F. Annunziato^3|5, V. Santini^1|4

¹ MDS Unit, Hematology, DMSC, University of Florence

² Department of Medical Biotechnologies, University of Siena

³ Flow Cytometric and Immunotherapeutic Diagnostic Center, AOU Careggi

⁴ Azienda Ospedaliero-Universitaria Careggi, Hematology department University of Florence

⁵ Department of Experimental and Clinical Medicine, University of Florence, Italy

https://doi.org/10.3324/haematol.2026.s1.101

P031 | From haematological disorders to immune dysregulation: the role of extended immunophenotyping to guide the diagnosis towards inborn errors of immunity (136 Online Views)

¹ Department of Biomedicine and Prevention, PhD program in immunology, molecular medicine, and applied biotechnologies, University of Rome Tor Vergata

² Haemophilia Centre, Immune-Haematology and Transfusion Medicine, University Hospital “Città

³ della Salute e della Scienza”

⁴ Department of Biomedicine and Prevention, University of Rome Tor Vergata

⁵ Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Rome Tor

⁶ Vergata Vergata

⁷ Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Gesù Children Hospital

⁸ Department of Systems Medicine, Tor Vergata University

https://doi.org/10.3324/haematol.2026.s1.102

P033 | Double marker strategy to measurable residual disease assessment in Philadelphia-like acute lymphoblastic leukemia (121 Online Views)

D. Cardinali¹, F. Kaiser¹, I. Della Starza^1|2, V. Bellomarino¹, M. Di Trani¹, L. Elia¹, L. Fucci¹, L. Cappelli¹, M. Ansuinelli¹, M. Martelli¹, R. Foà¹, S. Chiaretti¹

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome

² AIL Roma ODV, Italy

https://doi.org/10.3324/haematol.2026.s1.103

P034 | Association of ZAP70 expression and central nervous system infiltration and relapse in adults with acute lymphoblastic leukemia (102 Online Views)

F. Kaiser¹, D. Cardinali¹, L. Cappelli¹, M. Di Trani¹, F. Malfona¹, I. Della Starza^1|2, V. Bellomarino¹, L. Elia¹, M. Ansuinelli¹, L. Fucci¹, M. Martelli¹, R. Foà¹, S. Chiaretti¹

¹ Ematologia, Dipartimento di Medicina Traslazionale e di Precisione, Sapienza Università di Roma

² AIL Roma ODV

https://doi.org/10.3324/haematol.2026.s1.104

P035 | Venetoclax shows robust and subtype dependent preclinical activity in acute lymphoblastic leukemia models characterized by BCL2 dependence (118 Online Views)

F. L. Schiavo¹, G. Martinelli², C. Salvesi¹, L. Ledda¹, A. Spedaluzzi¹, E. Fonzi³, A. G. L. Di Rorà⁴, C. Papayannidis⁵, P. Salutari⁶, M. Rondoni⁷, G. Marconi⁸, A.M. Mianulli⁹, M. B. Giannini¹⁰, F. Giglio¹¹, C. Pasciolla¹², M. Fumagalli¹³, A. Imovilli¹⁴, E. Mauro¹⁵, S. Galimberti¹⁶, G. Simonetti¹, A. Ferrari¹

¹ Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori"

² University of Bologna, Istituto di Ematologia “Seràgnoli”

³ Unit of Biostatistics and Clinical Trials, IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori"

⁴ Fondazione Pisana per Scienza ONLUS

⁵ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

⁶ Dipartimento Oncologia Ematologia, Ospedale Civile Santo Spirito

⁷ Hematology Unit, Ospedale S. Maria delle Croci

⁸ Hematology Unit, University of Bologna, S. Maria delle Croci Hospital

⁹ Hematology Infermi Hospital

¹⁰ Hematoloy Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori"

¹¹ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute

¹² Hematology and Bone Marrow Transplantation Unit, Istituto Oncologico IRCCS "Giovanni Paolo II"

¹³ Hematology Unit, Ospedale San Gerardo

¹⁴ Hematology Azienda USL-IRCCS Reggio Emilia

¹⁵ UOC Ematologia Ospedale Ca' Foncello Azienda ULSS 2 Marca Trevigiana

¹⁶ Hematology Unit AOUP Santa Chiara

https://doi.org/10.3324/haematol.2026.s1.105

P036 | Germline and somatic cohesin genes alterations in pediatric acute lymphoblastic leukemia (123 Online Views)

D. Gaspari¹, S. Rebellato¹, L. Rigotti², A. Lettieri³, S. Castiglioni³, C. Saitta¹, L.. Bettini¹, D. Silvestri¹, M. Mariani⁴, S. Totaro³, O. Spinelli⁵, A. Pastorczak⁶, D. Brandes⁷, U. Fischer⁴, A. Borkhardt⁴, S. Strehl⁸, L. L. Nigro⁹, B. Buldini¹⁰, J. Hauer¹¹, F. Auer¹¹, L. Kester¹², R. Kuiper^12|13, L. Vinti¹⁴, F. Locatelli^14|15, C. Gervasini^3|16, V. Massa^3|16, A. Selicorni⁴, G. Fazio¹, G. Cazzaniga^1|17

¹ Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori

² Dep. of Paediatrics, V. Buzzi Children's Hospital, University of Milan

³ Dep. of Health Sciences, University of Milan

⁴ UOC Paediatrics, Centro Fondazione Mariani per il Bambino Fragile, ASST Lariana

⁵ Hematology and bone Marrow Transplant Unit, ASST-Papa Giovanni XXIII Hospital

⁶ Department of Pediatrics, Oncology and Hematology, Medical University of Lodz

⁷ Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf

⁸ St. Anna Children’s Cancer Research Institute

⁹ Cytogenetic-Cytofluorimetric-Molecular Biology Laboratory Center of Pediatric Hematology Oncology, Azienda Policlinico "G. Rodolico"

¹⁰ Department of Pediatric Hematology and Oncology, University-Hospital of Padova

¹¹ Technical University of Munich, School of Medicine, Department of Pediatrics

¹² Princess Maxima Center for Pediatric Oncology

¹³ Department of Genetics, Utrecht University Medical Center

¹⁴ IRCCS Ospedale Pediatrico Bambino Gesù

¹⁵ Catholic University of the Sacred Heart

¹⁶ “Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan

¹⁷ Medical Genetics, Università di Milano Bicocca

https://doi.org/10.3324/haematol.2026.s1.106

P038 | Targeted digital analysis provides high-resolution, clinically-relevant copy number alterations and enables the identification of high-risk lesions already known in adult acute lymphoblastic leukemia (100 Online Views)

C. Salvesi¹, G. Martinelli², F. L. Schiavo¹, M. Paganelli¹, A. Spedaluzzi¹, L. Ledda¹, C. Papayannidis³, G. Marconi⁴, M. Rondoni⁵, A.M. Mianulli⁶, B. Giannini⁷, C. Pasciolla⁸, F. Giglio⁹, S. Galimberti¹⁰, M. Fumagalli¹¹, P. Salutari¹², C. Terragna¹³, M.B. Giannini¹⁴, G. Montalban¹⁵, L. Atanesyan¹⁵, S. Savola¹⁵, G. Simonetti¹, A. Ferrari¹

¹ Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori"

² University of Bologna, Istituto di Ematologia “Seràgnoli”

³ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

⁴ Hematology Unit, University of Bologna, S. Maria delle Croci Hospital

⁵ Hematology Unit & Romagna Transplant Network, S. Maria delle Croci hospital

⁶ Hematology, Infermi Hospital

⁷ Laboratorio Unico- AUSL della Romagna Pievesestina di Cesena

⁸ Hematology and Bone Marrow Transplantation Unit, Istituto Oncologico IRCCS “Giovanni Paolo II”

⁹ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute

¹⁰ Hematology Unit, AOUP Santa Chiara

¹¹ Hematology Unit, Ospedale San Gerardo

¹² Dipartimento Oncologia Ematologia, Ospedale Civile Santo Spirito

¹³ IRCCS - Azienda Ospedaliero Universitaria di Bologna Laboratorio di Biologia Molecolare - Istituto di Ematologia "Seràgnoli"

¹⁴ Hematology Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori"

¹⁵ MRC Holland Company

https://doi.org/10.3324/haematol.2026.s1.107

P039 | Targeting oncogene-induced senescence in ETV6::RUNX1 pre-leukemic cells (126 Online Views)

D. Acunzo¹, M. Bertagna¹, G. Risca², L. Beneforti¹, S. Bresolin^3|4, S. Galimberti^2|5, I. Sánchez-García^6|7, A. Biondi¹, G. Cazzaniga^1|8, C. Palmi¹

¹ Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori

² Bicocca Bioinformatics, Biostatistics and Bioimaging Centre

³ Pediatric Hematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University and Hospital

⁴ Onco-Hematology, Stem Cell Transplant and Gene Therapy, Istituto di Ricerca Pediatrica Foundation - Città della Speranza

⁵ Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori

⁶ Institute for Biomedical Research of Salamanca

⁷ Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca

⁸ School of Medicine and Surgery, University of Milano-Bicocca

https://doi.org/10.3324/haematol.2026.s1.108

P040 | Metabolic reprogramming and DNA repair plasticity fuel resistance to long-term CHK1/CHK2 inhibition in B-cell acute lymphoblastic leukemia (117 Online Views)

¹ Fondazione Pisana per la Scienza Onlus

² University of Pisa

³ WellMicro srl

⁴ Istituto Romagnolo per lo studio dei Tumori "Dino Amadori"

⁵ Dipartimento di Scienze Mediche e Chirurgiche-Università di Bologna

⁶ NEST laboratory, Scuola Normale Superiore, Italy

https://doi.org/10.3324/haematol.2026.s1.109

P041 | Acute myeloid leukemia across ages: metabolic rewiring and genomic hotspots in adult and pediatric therapy resistance (98 Online Views)

C. Banella¹, G. Mattei¹, S. Travaglini², M. Ascone¹, A. Pasha³, M. Veltroni¹, A. Magi³, E. Sieni¹, A. Tondo¹, N.I. Noguera^3|4, M. Calvani¹

¹ AOU IRCCS Meyer

² Università degli Studi di Roma Tor Vergata

³ Università degli Studi di Firenze

⁴ IRCCS Fondazione Santa Lucia, Italy

https://doi.org/10.3324/haematol.2026.s1.110

P042 | PU.1 as master regulator of acute myeloid leukemia venetoclax resistance (136 Online Views)

A. Ferrando¹, B. Yalcin¹, C. Panuzzo¹, R. Vacca¹, A. Danzero¹, S. Rocco¹, A. Maglione¹, C. Fava¹, B. Pergolizzi¹, D. Cilloni¹

¹ Dept. of Clinical and Biological Sciences, University of Turin, Italy

https://doi.org/10.3324/haematol.2026.s1.111

P044 | From cells to vesicles: next-generation measurable residual disease tracking in acute myeloid leukemia with NGS and digital PCR (118 Online Views)

¹ Centro di Ricerca Emato-Oncologico AIL, ASST Spedali Civili di Brescia

² Unit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia

³ Hematology Unit, ASST Spedali Civili di Brescia

https://doi.org/10.3324/haematol.2026.s1.112

P045 | Targeting the β3-adrenergic–ferroptotic axis uncovers a metabolic vulnerability in T-cell acute lymphoblastic leukemia (111 Online Views)

C. Banella¹, S. Travaglini², G. Mattei¹, M. Ascone¹, R. Amato¹, A. Pasha¹, E. Chiocca¹, A. Tondo¹, M. Veltroni¹, M. Calvani¹

¹ AOU IRCCS Meyer

² Università degli Studi di Roma Tor Vergata

https://doi.org/10.3324/haematol.2026.s1.113

P046 | Beyond the mutation: prognostic role of FLT3-ITD length and genomic context in acute myeloid leukemia (125 Online Views)

¹ Centro di Ricerca Emato-oncologico AIL, ASST Spedali Civili di Brescia

² Unit of Blood Diseases and Bone Marrow Transplantation, Cell Therapies and Hematology Research Program, Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia

³ Department of Clinical Laboratory, ASST Spedali Civili di Brescia

⁴ Hematology Unit, ASST Spedali Civili di Brescia

⁵ Division of Biotechnology, Department of Molecular and Translational Medicine, University of Brescia

⁶ Department of Molecular and Translational Medicine, University of Brescia

⁷ Highly Specialized Laboratory, ASST Spedali Civili di Brescia

https://doi.org/10.3324/haematol.2026.s1.114

P047 | NGS analysis in acute myeloid leukemia: implications for the identification of predisposing germline variants (128 Online Views)

B. Giannini¹, L. Bagli¹, A. Nicoletti¹, G. F. Prisinzano¹, M.T. Bochicchio¹, M. Rondoni², G. Marconi², A.M. Mianulli³, F. Monaco³, M.B. Giannini^4|5, M. N. Marianna^4|5, I. Melandri¹, M. Lacchini¹, D. Aufiero¹, P. Altana¹, C. Arlotti¹, D. Ciccarelli¹, E. Emiliani¹, O. Donati¹, C. Graziano¹

¹ Lab Unico AUSL della Romagna U. O. Genetica Medica

² U. O. di Ematologia Ravenna AUSL della Romagna

³ U. O. di Ematologia Rimini AUSL della Romagna

⁴ Hematology Unit

⁵ IRCCS - Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" -IRST S.r.l

https://doi.org/10.3324/haematol.2026.s1.115

P048 | Autophagy inhibition potentiates midostaurin efficacy in FLT3-mutated acute myeloid leukemia under hypoxic conditions (104 Online Views)

C. Mosca^1|2, S. Bruno^1|2, M. Mancini^1|3, D. Forte¹, S. De Santis¹, L. Romagnoli¹, S. Soverini¹

¹ DIMEC- Department of Medical and Surgical Science-University of Bologna

² Center for Applied Biomedical Research CRBA, University of Bologna

³ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy

https://doi.org/10.3324/haematol.2026.s1.116

P049 | NUP98 degradation by (S)-ACE-OH induces NPM1c destabilization and loss of the leukemic phenotype in NPM1-mutated acute myeloid leukemia cells (155 Online Views)

A. Gagliardi¹, S. Peruzzi¹, A. Scialdone¹, L. Brunetti²

¹ Centro Ricerche Emato-Oncologiche CREO, Università di Perugia

² Università Politecnica delle Marche, Italy

https://doi.org/10.3324/haematol.2026.s1.117

P053 | Acute myeloid leukemia-derived extracellular vesicles induced DNA methylation changes responsible for inflammatory program in normal hematopoietic stem progenitor cells (94 Online Views)

D. Lamorte¹, G. Calice¹, S. Trino¹, M. Santodirocco², A. Caivano³, L. De Luca³, I. Laurenzana¹

¹ Laboratory of Preclinical and Translational Research, IRCCS Centro di Riferimento Oncologico della Basilicata - CROB

² Trasfusional Medicine Department, Puglia Cord Blood Bank, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital

³ Unit of Clinical Pathology, IRCCS Centro di Riferimento Oncologico della Basilicata CROB

https://doi.org/10.3324/haematol.2026.s1.118

P054 | Discontinuation of venetoclax-based therapies in molecularly selected patients with acute myeloid leukemia in complete remission (128 Online Views)

G. Ciolli¹, F. Mannelli^1|2, M. Frigeni³, M. Piccini¹, B. Scappini¹, F. Crupi^1|2, E. Quinti¹, A. Pasquini¹, J. Caroprese¹, G. Cannetti¹, G. Rotunno², F. Pancani², L. Signori², C. Maccari², P. Guglielmelli^1|2, A. Rambaldi³, A.M. Vannucchi^1|2

¹ Hematology Department, Azienda Ospedaliero-Universitaria Careggi

² Center for Innovation and Research in Myeloproliferative Neoplasms, Hematology Unit, Azienda Ospedaliera Universitaria Careggi, Department of Experimental and Clinical Medicine, University of Florence

³ Hematology & Bone Marrow Transplantation Unit, Azienda Socio-Sanitaria Territoriale ASST Ospedale Papa Giovanni XXIII

https://doi.org/10.3324/haematol.2026.s1.119

P055 | First interim analysis of venetoclax real-world observational study on newly-diagnosed acute myeloid leukemia patients in Italy (150 Online Views)

E. Todisco¹, C. Alati², E. Audisio³, M. Lunghi⁴, P. Zappasodi⁵, A. Curti⁶, V. Calafiore⁷, V. Federico⁸, M. Parisi⁹, S. Prassede¹⁰, M. Breccia¹¹, V. Cardinali¹², M. Frigeni¹³, M. Piccini¹⁴, D. Capelli¹⁵, N.S. Fracchiolla¹⁶, L. Maurillo¹⁷, L. Rizzo¹⁸, A. Candoni¹⁹, E. De Bellis²⁰, S. Vitiello²¹, A. Di Veroli²², B. Serio²³, I. Zacheo²⁴, L. Di Caprio²⁵, P. Finsinger²⁵, G. Gualberti²⁵, B. Neri²⁵, M. Ubezio²⁶

¹ SC Hematology, "Busto Arsizio" Hospital, ASST Valle Olona

² U. O. C. of Haematology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli

³ Complex Structure of Hematology, AO Città della Salute e della Scienza

⁴ Department of Translational Medicine, Division of Hematology, Universita' del PiemonteOrientale and Azienda Ospedaliero-Universitaria Maggiore della Carità

⁵ Division of Hematology, Foundation, IRCCS Policlinico San Matteo

⁶ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Institute of Hematology “Seràgnoli”

⁷ Onco-Hematology Unit, AOR Villa Sofia-Vincenzo Cervello

⁸ Hematology and Stem Cell Transplant Unit "Vito Fazzi" Hospital

⁹ Hematology Unit with BMT, A. O. U. Policlinico “G. Rodolico-San Marco”

¹⁰ Hematology Unit, Santo Spirito Civil Hospital

¹¹ Hematology, Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University

¹² Hematology Section, Perugia University Hospital

¹³ Hematology and Bone Marrow Transplantation Unit, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII

¹⁴ SOD Hematology, Azienda Ospedaliera Universitaria Careggi

¹⁵ Hematology Department, University of Ancona, Azienda Ospedaliero Universitaria delle Marche

¹⁶ SC Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

¹⁷ AOU Policlinico Tor Vergata, UOSD Patologie Mieloproliferative

¹⁸ ASST Grande Ospedale Metropolitano Niguarda Dipartimento ematologia ed oncologia

¹⁹ Section of Hematology, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia

²⁰ UCO Hematology, Azienda Sanitaria Universitaria Giuliano Isontina

²¹ Hematology Unit, AORN Cardarelli Hospital

²² UOC Hematology S. Rosa Viterbo Hospital

²³ Hematology and Transplant Center, University Hospital "San Giovanni di Dio e Ruggi d'Aragona"

²⁴ IRST IRCCS, Meldola

²⁵ AbbVie srl

²⁶ IRCCS Humanitas Research Hospital

https://doi.org/10.3324/haematol.2026.s1.120

P056 | Minimal residual disease monitoring in Ph+ acute lymphoblastic leukemia by next generation sequencing and digital droplet PCR for Ig/TR gene rearrangement preliminary results from the GIMEMA ALL2820 protocol (158 Online Views)

V. Bellomarino¹, I. Della Starza^1|2, D. Cardinali¹, F. Kaiser¹, I. D’Antuono¹, L. Elia¹, M. Beldinanzi¹, M. Di Trani¹, E. Gini¹, G. Almici¹, R. Foà¹, S. Chiaretti¹

¹ Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome

² AIL-Roma ODV, Italy

https://doi.org/10.3324/haematol.2026.s1.121

P057 | Prognostic impact of extended molecular characterization by next-generation sequencing in intermediate risk acute myeloid leukemia treated with intensive induction chemioterapy: a retrospective monocentric study (92 Online Views)

F. Campagna¹, T. Liani², C. Callegari¹, M. Moro², C. Cozzarolo¹, S. Di Giusto¹, C. Filì¹, D. Lazzarotto¹, M. Fanin¹, G. Battaglia¹, R. Fanin^1|2, E. Toffoletti^1|2, M. Tiribelli^1|2

¹ Division of Hematology and Bone Marrow Transplantation, Azienda Sanitaria Universitaria Friuli Centrale

² Department of Medicine, DMED, University of Udine

https://doi.org/10.3324/haematol.2026.s1.122

P058 | Ct-DNA-based liquid biopsy of cerebrospinal fluid in an adult with meningeal relapse of acute lymphoblastic leukaemia Ph⁺ (121 Online Views)

P. Cercola¹, D. Guadagnolo^1|2, S. Fazio¹, E. Sangiorgi¹, F. P. Serafini¹, I. Fulvi¹, L. Gerboni¹, G. Proietti¹, D. Remotti³, V. Ranucci³, R. Latagliata⁴, G. Trapè⁴, C. Mercanti⁴, G. Topini⁵, S. Quattrociocchi¹, M. Tonizza¹, G. Pessina¹

¹ UOSD Laboratorio di Genetica Medica Ospedale Santa Rosa ASL Viterbo

² Department of Molecular Medicine Sapienza University of Rome

³ UOC Anatomia Patologica Ospedale Santa Rosa ASL Viterbo

⁴ UOC Ematologia Ospedale Santa Rosa ASL Viterbo

⁵ UOC Diagnostica Clinica Polo Ospedale Santa Rosa ASL Viterbo

https://doi.org/10.3324/haematol.2026.s1.123

P059 | WT1 reduction after induction therapy predicts outcome in AML patients (97 Online Views)

C. Marzano¹, M. Cuccaro¹, A. Santoni¹, M. Malchiodi¹, A. Sicuranza¹, M. Rondoni², G. Marconi², K. Palombo², A. Cartocci³, C. Turriziani¹, F. Lanza², M. Bocchia¹

¹ Hematology Unit, University of Siena, Azienda Ospedaliera Universitaria Senese, Siena

² Hematology Unit, University of Bologna, Ospedale S. Maria delle Croci

³ Department of medical science, surgery and neurosciences, University of Siena, Siena

https://doi.org/10.3324/haematol.2026.s1.124

P060 | Integration of genomic and clinical data in acute myeloid leukemia: actual performance of the Sanger multistage prognostic model (116 Online Views)

A. Duminuco¹, S. Vitale², A. Nardo¹, S. Stella², M. Massimino², C. Tomarchio², F. Di Raimondo¹, C. Vetro³, L. Manzella², G. A. Palumbo¹

¹ Hematology Unit, AOU Policlinico "G. Rodolico-San Marco"

² Center of Experimental Oncology and Hematology, AOU Policlinico "G. Rodolico-San Marco"

³ Hematology and BMT Unit, Hospital of Bolzano SABES-ASDAA, Teaching Hospital of Paracelsus Medical University

https://doi.org/10.3324/haematol.2026.s1.125

P061 | Clinical outcomes of younger adult patients with Philadelphia-negative acute lymphoblastic leukemia, treated in the real-life with a pediatric-like regimen based on GIMEMA LAL1308 protocol: an observational retrospective campus all study (105 Online Views)

F. Forghieri¹, C. Caterina¹, D. Lazzarotto², M. Annunziata³, E. Lugli⁴, M. Ciccone⁵, M. Dargenio⁶, C. Papayannidis⁷, F. Mosna⁸, P. Chiusolo^9|10, F. Guolo^11|12, C. Buquicchio¹³, S. Cordella¹, M. Bonifacio^14|15, F. Ferrara³, G. Pizzolo^14|15, R. Foà¹⁶, A. Candoni^1|17, M. Luppi¹, A. M. Testi¹⁶

¹ Department of Medical and Surgical Sciences, Section of Hematology. University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena

² Clinica Ematologica - Centro Trapianti e Terapie Cellulari, Azienda Sanitaria Universitaria Friuli Centrale

³ Hematology Unit, Hospital “Antonio Cardarelli”

⁴ Ematologia, Azienda USL - IRCCS di Reggio Emilia

⁵ UO Ematologia, Dipartimento di Medicine Specialistiche, Azienda Ospedaliero-Universitaria Arcispedale S. Anna

⁶ S. C. Ematologia, Ospedale Vito Fazzi

⁷ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”

⁸ Hematology and Bone Marrow Transplantation Unit

⁹ Hematology Unit, Dipartimento Scienze di Laboratorio ed Ematologiche, Fondazione Policlinico Universitario A. Gemelli – IRCCS

¹⁰ Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Università Cattolica del Sacro Cuore

¹¹ Clinica Ematologica, Dipartimento di Medicina Interna

¹² IRCCS Ospedale Policlinico San Martino

¹³ Hematology and Bone Marrow Transplant Unit, Ospedale Monsignor R. Dimiccoli. Barletta

¹⁴ Department of Engineering for Innovation Medicine, Section of Hematology, University of Verona

¹⁵ Department of Medicine, Azienda Ospedaliera Universitaria Integrata di Verona

¹⁶ Unità di Ematologia, Dipartimento di Medicina Traslazionale e di Precisione, “Sapienza” Università di Roma

¹⁷ Hematology Section, Dipartimento di Medicina Specialistica, Ca' Foncello Hospital

https://doi.org/10.3324/haematol.2026.s1.126

P062 | Interim results of the questionnaire on predisposition to acute lymphoblastic leukemia in the AIEOP-BFM ALL 2017 protocol (120 Online Views)

L. R. Bettini¹, M. Lattuada², D. Silvestri³, L. L. Nigro⁴, N. Bertorello⁵, R. Parasole⁶, M.C. Putti⁷, F. Locatelli⁸, V. Conter³, M. G. Valsecchi⁹, A. Biondi¹, C. Rizzari¹, G. Cazzaniga^2|3

¹ Pediatrics, Fondazione IRCCS San Gerardo dei Tintori

² School of Medicine and Surgery, University of Milano-Bicocca

³ Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori

⁴ Pediatric Hematology and Oncology Center, Azienda Policlinico G. Rodolico - San Marco

⁵ Pediatric Hematology-Oncology Unit, Regina Margherita Children’s Hospital

⁶ Pediatric Hematology and Oncology, AORN Santobono-Pausilipon

⁷ Pediatric Hemato-Oncology Clinic, Department of Women’s and Children’s Health, University Hospital - University of Padua

⁸ Department of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children’s Hospital

⁹ Center for Bioinformatics, Biostatistics and Bioimaging, University of Milano-Bicocca and Fondazione IRCCS San Gerardo dei Tintori

https://doi.org/10.3324/haematol.2026.s1.127

P063 | Analysis of the expression profile of long non-codingRNAs in patients affected by T-cell large granular lymphocyte leukemia (96 Online Views)

¹ Department of Medicine, Hematology Branch, University of Padova

² Veneto Institute of Molecular Medicine - VIMM

³ Section of General Pathology, Department of Medicine, University of Verona, Italy

https://doi.org/10.3324/haematol.2026.s1.128

P064 | XPO1 mutations drive BCR hyperactivation and early disease progression in chronic lymphocytic leukemia (101 Online Views)

C. Cosentino¹, E. Tissino², R. Bomben², T. Bittolo², F.M. Rossi², A. Gaglio², R. Mozzillo², M. Almasri¹, R. Dondolin¹, M. Bellia¹, S. Rasi¹, E. Secomandi¹, J. Nabki¹, B. A. Deeban¹, L. Cividini¹, F. Maiellaro¹, J. Ghanej¹, A. Mahmoud¹, S. Kogila¹, S. Mouhssine¹, N. Maher¹, G. Gaidano¹, V. Gattei², A. Zucchetto², R. Moia¹

¹ Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale

² Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico di Aviano CRO, IRCCS, Italy

https://doi.org/10.3324/haematol.2026.s1.129

P065 | Clinical and genomic patterns of disease progression in CLL patients treated with fixed-duration versus continuous targeted therapies (101 Online Views)

A. Serafin¹, F. Angotzi¹, A. Bevilacqua¹, A. Cellini¹, M. D’antiga¹, L. Bonaldi², A. Martines², E. Albi³, E. Sant’antonio³, F. Martini³, S. De Antoni², S. Pepe⁴, I. Cavallari², A. Noto⁵, A.M. Frustaci⁵, F.R. Mauro⁴, P. Ghia^3|6, L. Scarfò^3|6, L. Trentin¹, A. Visentin¹

¹ Hematology Unit, Department of Medicine, University of Padova

² Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCSS

³ Strategic Research Program on CLL, IRCCS Ospedale San Raffaele

⁴ Hematology, Department of Translational and Precision Medicine, "Sapienza" University

⁵ Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda

⁶ Medical School, Università Vita-Salute San Raffaele

https://doi.org/10.3324/haematol.2026.s1.130

P066 | STAT3-mediated circular RNAs dysregulation in neutropenic T-large granular lymphocyte leukemia patients (92 Online Views)

¹ Department of Medicine, Hematology Branch, University of Padova

² Veneto Institute of Molecular Medicine – VIMM

³ Department of Molecular Medicine, University of Padova

⁴ Department of Biology, University of Padova

⁵ Department of Surgery, Oncology and Gastroenterology, University of Padova

https://doi.org/10.3324/haematol.2026.s1.131

P067 | Catalase blocking enhances drug sensitivity to BCL-2 inhibitors in chronic lymphocytic leukemia (91 Online Views)

¹ Department of Engineering for Innovation Medicine, Section of Biomedicine, University of Verona

² Hematology Unit, Azienda Ospedaliera Universitaria Integrata Verona

³ Department of Diagnostic and Public Health, University of Verona

⁴ Research Center LURM Interdepartmental Laboratory of Medical Research, University of Verona

⁵ Department of Medicine, University of Verona

https://doi.org/10.3324/haematol.2026.s1.132

P068 | MiR-146b restoration in T-large granular lymphocyte leukemia: molecular insights for a new therapeutic strategy against neutropenia development (107 Online Views)

¹ Department of Medicine, Hematology Unit, University of Padova

² Veneto Institute of Molecular Medicine - VIMM

³ Department of Biology, University of Padova

⁴ Computational Genomics Group, Department of Surgery, Oncology and Gastroenterology, University of Padova

⁵ Department of Medicine, Division of General Pathology, University of Verona

⁶ Department of Molecular Medicine, University of Padova

https://doi.org/10.3324/haematol.2026.s1.133

P069 | Characterization of FAK-p53 functional relationship in chronic lymphocytic leukemia cells (91 Online Views)

G. Capasso¹, A. Beltrame¹, M. Castronuovo¹, V. Gramegna¹, E. Pagnin¹, P. Fantato¹, I. Olimpo¹, A. Cellini¹, F. Angotzi¹, A. Serafin¹, A. Visentin¹, L. Trentin¹, F. Frezzato¹

¹ Hematology Unit, Department of Medicine, University of Padua, Italy

https://doi.org/10.3324/haematol.2026.s1.134

P071 | FAK inhibition with defactinib enhances BTK inhibitor efficacy and overcomes microenvironmental protection in chronic lymphocytic leukemia (117 Online Views)

M. Castronuovo¹, A. Beltrame¹, V. Tatangelo², L. Lopresti², L. Patrussi², G. Capasso¹, V. Gramegna¹, P. Fantato¹, V. Trimarco¹, A. Visentin¹, L. Trentin¹, F. Frezzato¹

¹ Hematology Unit, Department of Medicine, University of Padua

² Department of Life Sciences, University of Siena

https://doi.org/10.3324/haematol.2026.s1.135

P072 | Focal adhesion kinase FAK interplays with ROR1 in chronic lymphocytic leukemia (89 Online Views)

V. Gramegna¹, M. Castronuovo¹, A. Beltrame¹, G. Capasso¹, P. Fantato¹, E. Pagnin¹, F. Angotzi¹, A. Cellini¹, A. Serafin¹, M. Facco¹, A. Visentin¹, L. Trentin¹, F. Frezzato¹

¹ Hematology Unit, Department of Medicine, University of Padua

https://doi.org/10.3324/haematol.2026.s1.136

P073 | Focal adhesion kinase as a novel therapeutic target in hairy cell leukemia (80 Online Views)

P. Fantato¹, F. Frezzato¹, M. Castronuovo¹, A. Beltrame¹, G. Capasso¹, V. Gramegna¹, V. Trimarco¹, A. Cellini¹, F. Angotzi¹, A. Serafin¹, A. Visentin¹, L. Trentin¹

¹ Hematology Unit, Department of Medicine, University of Padua, Italy

https://doi.org/10.3324/haematol.2026.s1.137

P074 | Innovative MRD detection and immune profiling in relapsed CLL treated with rituximab-venetoclax: insights from the “Dedalus” protocol (97 Online Views)

M. D’Amato¹, C. Baratè¹, C. Bono¹, F. Guerrini¹, G. Tancredi¹, E. Benedetti¹, S. Galimberti¹

¹ University of Pisa, Italy

https://doi.org/10.3324/haematol.2026.s1.138

P077 | Clinical profiles and treatment approaches in Italian patients with CLL in clinical practice: findings from a European cross-sectional survey (106 Online Views)

S. Baffini¹, M. Chisini¹, R. Adamoli¹, A. Tamma¹, G. Segall², N. Milloy³, A. Lambert³, A. Simpson³, A. Avitabile¹

¹ Eli Lilly Italia S.p.A

² Eli Lilly and Co

³ Adelphi Real World

https://doi.org/10.3324/haematol.2026.s1.139

P078 | A prospective study on high resolution ultrasound assessment of superficial lymphonodes of CLL patients during BTKi treatment: comparison of dimensional response vs overall ultrasound assessment in general practice (86 Online Views)

E. Benedetti^1|2, M.C. Caparello¹, C. Barate³, R. Morganti⁴, E. Bramanti⁵, S. Galimberti¹

¹ Azienda Ospedaliero Universitaria Pisana, Hematology Unit, Department of Clinical and Experimental Medicine

² Italian School of Basic and Emergency Ultrasound - SIUMB

³ Ospedale Niguarda Milano

⁴ Azienda Ospedaliero Universitaria Pisana, Section of Statistics

⁵ Institute of Chemistry of Organometallic Compounds - ICCOM, Italian National Research Council - CNR

https://doi.org/10.3324/haematol.2026.s1.140

P079 | Assessment by high resolution ultrasound sonography of patients with chronic lymphocytic leukemia treated with BTK inhibitors. Clinical and pharmacoeconomic impact (83 Online Views)

E. Benedetti^1|2, M.C. Caparello¹, B. Bruno³, S. Galimberti¹, E. Bramanti⁴, R. Morganti⁵, E. Capochiani⁶

¹ Azienda Ospedaliero Universitaria Pisana, Hematology Unit, Department of Clinical and Experimental Medicine

² Italian School of Basic and Emergency Ultrasound SIUMB

³ Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, University of Torino

⁴ Institute of Chemistry of Organometallic Compounds ICCOM, Italian National Research Council CNR

⁵ Azienda Ospedaliero Universitaria Pisana, Section of Statistics

⁶ Hematology Unit Center for Translational Medicine Azienda USL Toscana NordOvest, Livorno

https://doi.org/10.3324/haematol.2026.s1.141

P080 | Targeting CK2 disrupts epigenetic plasticity and sensitizes diffuse large B-cell lymphoma cells to the EZH2 inhibitor tazemetostat (100 Online Views)

¹ Hematology Unit, Department of Medicine, University of Padova

² Veneto Institute of Molecular Medicine

³ Department of Surgery, Oncology and Gastroenterology, University of Padova

https://doi.org/10.3324/haematol.2026.s1.142

P081 | BTK inhibition induces differential responses of BCR signaling in basal or stimulated conditions in mantle cell lymphoma (90 Online Views)

¹ Hematology and Bone Marrow Transplant Unit, Section of Biomedicine of Innovation, Department of Engineering for Innovative Medicine, University of Verona

² Hematology and Bone Marrow Transplant Complex Operative Unit - UOC, Department with Integrated Activity - DAI - of General Medicine, University Hospital- AOUI - of Verona

³ Research Center LURM-Interdepartmental Laboratory of Medical Research, University of Verona

⁴ Department of Diagnostic and Public Health, University of Verona

⁵ Department of Medicine, University of Verona

⁶ Hematology and Cell Therapy Unit, IRCCS-Istituto Tumori "Giovanni Paolo II"

⁷ Department of Translational Medicine, Division of Hematology, University of Piemonte Orientale

https://doi.org/10.3324/haematol.2026.s1.143

P082 | Feasibility of immunoglobulin gene rearrangement tracking on circulating tumor DNA as an outcome predictor in primary mediastinal B-cell lymphoma (133 Online Views)

G.M. Assanto^1|2|3, I. D'Antuono¹, L. Donzelli¹, V. Bellomarino¹, I. Della Starza^1|4, M. Antonacci¹, D. Cardinali¹, M. Ansuinelli¹, L. Petrucci^1|3, A. Di Rocco¹, I. Del Giudice¹, M. Martelli¹

¹ Hematology, Department of translational and precision medicine, Sapienza University of Rome

² Department of Molecular Medicine, Sapienza University of Rome

³ AOU Policlinico Umberto I

⁴ AIL Roma Odv, Italy

https://doi.org/10.3324/haematol.2026.s1.144

P083 | The lncRNA MTAAT regulates PD-L1 trafficking via ARF6 in T-cell lymphoma: implications for immunotherapy (113 Online Views)

S. Mallia¹, G. Gambarelli^1|2, M. Zanelli³, B. Donati¹, D. Fiore⁴, I. Tamagnini³, F. Torricelli¹, P. Di Chiaro¹, F. Reggiani¹, N. Puccio¹, F. Sanguedolce⁵, S. Ascani⁶, S. Luminari⁷, F. Merli⁷, A. Neri⁸, A. Ciarrocchi¹, V. Fragliasso¹

¹ Laboratorio di Ricerca Traslazionale dell'AUSL-IRCCS di Reggio Emilia

² Medicina Clinica e Sperimentale Ph. D. Program dell'Università di Modena e Reggio Emilia

³ Unità di Patologia dell'AUSL-IRCCS di Reggio Emilia

⁴ Dipartimento di Medicina Molecolare e Biotecnologia Medica dell'Università Federico II

⁵ Unità di Patologia Policlinico Università di Foggia

⁶ Unità di Patologia dell'Azienda Ospedaliera di Santa Maria di Terni

⁷ Unità di Ematologia dell'AUSL-IRCCS di Reggio Emilia

⁸ Direzione Scientifica dell'AUSL-IRCCS di Reggio Emilia

https://doi.org/10.3324/haematol.2026.s1.145

P084 | Resistance to BET protein inhibitors is orchestrated by protein kinase CK2 in mantle cell lymphoma (95 Online Views)

¹ Hematology Unit, Department of Medicine, University of Padova

² Veneto Institute of Molecular Medicine

³ Department of Surgery, Oncology and Gastroenterology, University of Padova

https://doi.org/10.3324/haematol.2026.s1.146

P085 | Rewiring tumor-driven inflammation to restore immune surveillance in mantle cell lymphoma (156 Online Views)

¹ Hematology Unit, Department of Medicine, University of Padova

² Veneto Institute of Molecular Medicine

³ Department of Surgery, Oncology and Gastroenterology, University of Padova

https://doi.org/10.3324/haematol.2026.s1.147

P086 | ECM–DLBCL interactions drive reversible ibrutinib resistance in a 3D bone model (86 Online Views)

¹ Hematology Unit, Department of Medicine, University of Padua

² Laboratory of Myeloma and Lymphoma Pathobiology, Veneto Institute of Molecular Medicine

³ Internal Medicine and Allergology and Clinical Immunology Units, Treviso Ca' Foncello Hospital

⁴ Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua

⁵ Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology

https://doi.org/10.3324/haematol.2026.s1.148

P087 | Real-life experience with the POLA-R-CHP regimen in diffuse large B-cell lymphoma: a retrospective analysis (279 Online Views)

L. Scalise¹, L. Pezzullo², D. Pastore³, F. Merchionne³, G.R. Mansueto⁴, G. Pietrantuono⁴, E. Martino⁵, M. Gentile⁵, M. Rossi¹

¹ Azienda Osp. Univ. Renato Dulbecco Ematologia

² AOU San Giovanni Di Dio UOC Ematologia

³ UOC di Ematologia Osp. A. Perrino

⁴ IRCCS C.R.O. B Ematologia

⁵ UOC Ematologia Azienda Ospedaliera Cosenza, Italy

https://doi.org/10.3324/haematol.2026.s1.149

P088 | The impact of TP53 aberration in Richter transformation in the target therapies era: a real-life case series (109 Online Views)

M. D’amato¹, C. Baratè¹, A. Votto¹, F. Facella¹, E. Benedetti¹, S. Galimberti¹

¹ Department of Clinical and Experimental Medicine, Haematology Unit, University of Pisa

https://doi.org/10.3324/haematol.2026.s1.150

P090 | Charting residual disease trajectories in multiple myeloma using single-cell RNA and immune repertoire profiling (110 Online Views)

E. Calvi¹, F. Lazzaroni¹, F. Viviani¹, A. Matera¹, A. M., G. Castellano¹, A. Maeda¹, M. Scopetti², C. De Magistris¹, L. Pettine¹, S. Fabris¹, S. Pioggia¹, A. Marchetti¹, M. Barbieri¹, S. Lonati¹, M. Lionetti¹, F. Passamonti^1|2, M.C. Da Vià¹, N. Bolli^1|2

¹ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

² University of Milan, Department of Oncology and Hemato-Oncology

https://doi.org/10.3324/haematol.2026.s1.151

P091 | Dissection of NEAT1’s role in transcriptional regulation reveals actionable targets in high-risk multiple myeloma (100 Online Views)

N. Puccio¹, C. Boni¹, F. Torricelli¹, E. Vitale¹, E. Taiana², V. Fragliasso¹, S. Mallia¹, G. Gambarelli^1|3, N. Bolli^2|4, N. Amodio⁵, R. Piva⁶, S. Luminari⁷, A. Ciarrocchi¹, A. Neri⁸

¹ Azienda USL-IRCCS di Reggio Emilia, Laboratory of Translational Research

² Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Hematology Unit

³ University of Modena and Reggio Emilia, Clinical and Experimental Medicine PhD Program

⁴ University of Milan, Department of Oncology and Hemato-oncology

⁵ Department of Clinical and Experimental Medicine, Magna Graecia University

⁶ University of Turin, Department of Molecular Biotechnology and Health Sciences

⁷ Azienda USL-IRCCS di Reggio Emilia, Hematology Unit

⁸ Azienda USL-IRCCS di Reggio Emilia, Italy

https://doi.org/10.3324/haematol.2026.s1.152

P095 | Tumor burden and immune microenvironment influence response to anti-BCMA bispecific antibodies in relapsed/refractory multiple myeloma (96 Online Views)

E. Tofacchi¹, C. Aquilina¹, A.M. Corsale¹, M. Speciale¹, M. Biondo¹, A. Romano¹, E. Gigliotta¹, A. F. Terranova¹, F. Dieli², S. Meraviglia², A. Gallo³, F. Accardi⁴, S. Grimaudo¹, S. Siragusa¹, C. Botta¹

¹ Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties ProMISE "G. D'Alessandro", University of Palermo

² Department of Biomedicine, Neuroscience and Advanced Diagnosis, University of Palermo

³ Department of Research, IRCCS ISMETT - Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione-, UPMC

⁴ U. O. C di Oncoematologia, Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello, Italy

https://doi.org/10.3324/haematol.2026.s1.153

P096 | BCMA genotypes in relation to prognosis and induction and maintenance therapy in multiple myeloma patients (99 Online Views)

M.L. Del Giudice¹, M. Magrini², M. Vitiello², S. Mori², R. Silvestri², F. Rea², M. Cipollini², R. Foddis³, S. Galimberti¹, F. Gemignani², S. Landi², G. Buda¹

¹ Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa

² Genetic Unit, Department of Biology, University of Pisa

³ Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa

https://doi.org/10.3324/haematol.2026.s1.154

P098 | Glutamine-dependent anaplerotic rewiring with pyruvate carboxylase down-tuning underlies proteasome inhibitors resistance in multiple myeloma (123 Online Views)

D. Tibullo¹, L. Longhitano¹, J Ferrigno¹, E. La Spina¹, G.N. Conti¹, F. Bellia¹, A.M. Amorini¹, S. Giallongo², A. Duminuco³, G.A. Palumbo³, I. Dulcamare⁴, C. Conticello⁵, D. Cambria⁴, D. Calvo¹, T. Zuppelli¹, M. G. Cantafio⁵, G. L. Volti¹, N. Amodio⁵, D. R. -⁴, A. Romano⁴, C. Giallongo¹

¹ Department of Biomedical and Biotechnological Sciences, University of Catania

² Faculty of Medicine and Surgery, University of Enna “Kore”

³ Department of Medical and Surgical Sciences and Advanced Technologies “G. F. Ingrassia”, University of Catania

⁴ Department of General Surgery and Medical-Surgical Specialties- University of Catania, Division of Haematology

⁵ Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Italy

https://doi.org/10.3324/haematol.2026.s1.155

P099 | Exploring the transcriptional profile of DIS3 can unravel new targeting strategies in multiple myeloma (77 Online Views)

C. Boni¹, N. Puccio¹, F. Torricelli¹, E. Vitale¹, S. Mallia¹, I. Craparotta², L. Di Rito², V. Manicardi¹, V. Fragliasso¹, E. Taiana³, A. Ciarrocchi¹, A. Neri^1|4

¹ Laboratorio di ricerca traslazionale, AUSL-IRCCS

² Dipartimento di Oncologia, Istituto di Ricerche Farmacologiche Mario Negri IRCCS

³ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

⁴ Direttore scientifico, AUSL-IRCCS

https://doi.org/10.3324/haematol.2026.s1.156

P100 | Enhanced NAD^⁺ biosynthesis and PPP activation drive venetoclax resistance in multiple myeloma: therapeutic reversal by NAMPT inhibition (88 Online Views)

I. Traverso¹, D. Soncini^1|2, G. Giorgetti², S. Ravera³, J. Ivanisevic⁴, M. Garibotto², M. Gallo¹, F. Guolo^1|2, A. Cagnetta², R.M. Lemoli^1|2, M. Cea^1|2

¹ Clinic of Hematology, Department of Internal Medicine and Medical Specialties DiMI, University of Genoa

² IRCCS Ospedale Policlinico San Martino

³ Department of Experimental Medicine DIMES, University of Genoa, Italy

⁴ Metabolomics Unit, Faculty of Biology and Medicine, University of Lausanne, Switzerland

https://doi.org/10.3324/haematol.2026.s1.157

P101 | The long term prognostic impact of chromosome 1 abnormalities in newly diagnosed multiple myeloma patients (111 Online Views)

M. Bernardi¹, G. Todaro¹, G. Sammarelli¹, N.T. Iannozzi², A. Poletti², M. Scita¹, A.B. D. Palma¹, S. Ricci¹, C. Sitzia², P. Storti², N. Giuliani^1|2

¹ Programma Mieloma Multiplo e Gammopatie Monoclonali, U. O. Ematologia e CTMO, Azienda Ospedaliero-Universitaria di Parma

² Dipartimento di Medicina e Chirurgia, Università di Parma

https://doi.org/10.3324/haematol.2026.s1.158

P102 | Odissey: a multicenter, observational study of multiple myeloma patients who discontinued therapy in clinical practice (117 Online Views)

N. Sgherza¹, G. Di Carlo², P. Curci¹, O. Battisti¹, G. Palumbo³, C. De Risi⁴, A. G. Solimando⁵, G. Palazzo⁶, C. Germano⁷, A. Quinto⁸, G. Mele⁹, D. De Novellis¹⁰, M. Gentile^11|12, P. Musto^1|2

¹ Hematology and Stem Cell Transplantation Unit, AOUC Policlinico

² Department of Precision and Regenerative Medicine and Ionian Area, “Aldo Moro” University School of Medicine

³ Hematology Unit, AOU Policlinico Riuniti di Foggia

⁴ Haematology and Transplant Unit, “V. Fazzi” Hospital

⁵ Guido Baccelli Unit of Internal Medicine, Department of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J, School of Medicine, University of Bari Aldo Moro

⁶ Hematology Unit, “G. Moscati” Hospital

⁷ Hematology Unit,“Mons. Dimiccoli” Hospital

⁸ Hematology and Cell Therapy Unit, IRCCS “G. Paolo II”

⁹ Hematology Unit,“A. Perrino” Hospital

¹⁰ Hematology and Transplant Center, University Hospital "San Giovanni di Dio e Ruggi d'Aragona"

¹¹ Hematology Unit, Department of Onco-Hematology, AO of Cosenza

¹² Department of Pharmacy, Health and Nutritional Science, University of Calabria

https://doi.org/10.3324/haematol.2026.s1.159

P103 | Partial inhibition of NAMPT restores metabolic vulnerability and synergizes with anti-myeloma agents in multiple myeloma (106 Online Views)

¹ IRCCS Ospedale Policlinico San Martino

² Clinic of Hematology, Department of Internal Medicine and Medical Specialties DiMI, University of Genoa

³ Centre of Excellence for Biomedical Research, Department of Internal Medicine, University of Genoa

⁴ Department of Experimental Medicine DIMES, University of Genoa

⁵ Remedy Plan Therapeutics

https://doi.org/10.3324/haematol.2026.s1.160

P104 | Soluble BCMA mirrors bone marrow disease burden and predicts outcome in multiple myeloma patients (176 Online Views)

D. Soncini^1|2, I. Traverso¹, G. Giorgetti², A.E. Laserra¹, E. Catini¹, F. Guolo^1|2, M. Garibotto², A. Cagnetta², R.M. Lemoli^1|2, M. Cea^1|2

¹ Clinic of Hematology, Department of Internal Medicine and Medical Specialties

² IRCCS Ospedale Policlinico San Martino

https://doi.org/10.3324/haematol.2026.s1.161

P105 | Immunosuppressive and biological drugs do not influence progression of MGUS or smoldering multiple myeloma in patients with concomitant autoimmune disorders: preliminary data from a retrospective, single-center study (118 Online Views)

N. Sgherza¹, O. Magazzino², P. Curci¹, E. Resta³, O. Battisti¹, A. Vitucci¹, A. V. R. Rossi¹, F. Iannone⁴, P. Musto^1|2

¹ Hematology and Stem Cell Transplantation Unit, AOUC Policlinico

² Department of Precision and Regenerative Medicine and Ionian Area, “Aldo Moro” University School of Medicine

³ Department of Clinical and Molecular Medicine, Sapienza University

⁴ Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, “Aldo Moro” University School of Medicine

https://doi.org/10.3324/haematol.2026.s1.162

P106 | CD20 positive multiple myeloma: is it a different entity? (157 Online Views)

¹ UOC Diagnostica Clinica, Laboratorio di Citofluorimetria, Ospedale Santa Rosa, ASL Viterbo

² UOC Ematologia, Ospedale Santa Rosa

³ ASL Viterbo

⁴ Servizio di Medicina Trasfusionale

⁵ UOSD Laboratorio Genetica Medica, Ospedale Santa Rosa, ASL Viterbo

https://doi.org/10.3324/haematol.2026.s1.163

P107 | Karyotype evaluation according to patient age in multiple myeloma (88 Online Views)

M. Poscente¹, L. Bassi¹, R. Isidori¹, F. P. Serafini¹, G. Tomei², G. De Angelis², G. Trape’², M. Montanaro², M. L. Presti¹, F. Di Palma¹, S. Peruzzi¹, M. Tonizza¹, I. Bracoloni¹, V. Panichi³, G. Topini³, R. Latagliata², G. Pessina¹

¹ UOSD Laboratorio Genetica Medica, Ospedale Santa Rosa, ASL Viterbo

² UOC Ematologia, Ospedale Santa Rosa, ASL Viterbo

³ UOC Diagnostica Clinica, Laboratorio di Citofluorimetria, Ospedale Santa Rosa, ASL Viterbo

https://doi.org/10.3324/haematol.2026.s1.165

P108 | Is there a prognostic and diagnostic role of MYC rearrangements in multiple myeloma at diagnosis by fish? Description of 3 clinical cases (124 Online Views)

R. Isidori¹, L. Bassi¹, M. Poscente¹, F. P. Serafini¹, M. Tonizza¹, G. Gaetani¹, D. Dinarelli¹, F. Cesaretti¹, E. Sangiorgi¹, F. Di Palma¹, V. Panichi², G. Topini², G. Tomei³, G. De Angelis³, G. Trapè³, M. Montanaro³, R. Latagliata³, G. Pessina¹

¹ UOSD Laboratorio Genetica Medica, Ospedale Santa Rosa, ASL Viterbo

² UOC Diagnostica Clinica, Laboratorio di Citofluorimetria, Ospedale Santa Rosa, ASL Viterbo

³ UOC Ematologia, Ospedale Santa Rosa, ASL Viterbo

https://doi.org/10.3324/haematol.2026.s1.166

P109 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation (34 Online Views)

A. Benetti¹, A. Galbiati¹, M. Cola², L. Calandrino², C. Samà¹, D. Regazzo¹, S. Ferrari¹, C.M. Radu¹, A. Cattelan², P. Simioni¹

¹ Department of Medicine, Clinical Medicine 1, Padua University Hospital

² Infectious and Tropical Diseases Unit, Padua University Hospital

P110 | Molecular evaluation of ROCK2 and IGFBP6 dynamics following CAR-T therapy: potential biomarkers of inflammation (106 Online Views)

C. Bono^1|2, F. Guerrini¹, E. Orciuolo², G. Tancredi¹, M. La Russa¹, I. Santo¹, G. Leoni¹, A. Votto¹, G. Bolognesi¹, C. Baldini^1|2, G. Fulvio¹, A. Liso³, S. Galimberti^1|2

¹ Università di Pisa

² Azienda Ospedaliera Universitaria Pisana

³ Università di Perugia, Italy

https://doi.org/10.3324/haematol.2026.s1.167

P111 | Impact of T-cells fitness assessed by cytofluorimetry in patients treated with CAR-T therapy for malignant mature B-cell neoplasms (62 Online Views)

G. Tancredi¹, M. Franzini¹, E. Orciuolo¹, C. Bono¹, S. Balducci¹, G. Traverso¹, M.L. Del Giudice¹, S. Galimberti¹

¹ Hematology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy

https://doi.org/10.3324/haematol.2026.s1.167

P112 | IGFBP-6 as a potential regulator of platelet procoagulant activity (113 Online Views)

L. Bury¹, E. Falcinelli¹, E. Petito¹, L. Leijonancker², P. Gresele¹, A. Liso³

¹ Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia

² Pixelgen Technologies AB

³ Department of Medicine and Surgery, Hematology/Oncology Unit, Terni Hospital, University of Perugia, Italy

https://doi.org/10.3324/haematol.2026.s1.168

SIES Award | Neutrophil extracellular traps in myeloproliferative neoplasms: impact of cytoreductive therapy (144 Online Views)

E. Torre¹, A. Retter¹, N. Curto-Garcia¹, A. Sheikh¹, K. Thaw¹, L. Cadman-Davies¹, J. O'Sullivan¹, P. Sriskandarajah¹, P. Harrington¹, C. Woodley¹, S. Asirvatham¹, H. De Lavallade¹, D. Radia¹, C. Harrison¹, S. Kordasti¹

¹ Guy's and St. Thomas' NHS Foundation Trust, London, UK

https://doi.org/10.3324/haematol.2026.s1.169

Abstract book of the XIX Congress of the Italian Society of Experimental Hematology, Florence, 4-6 March 2026

SIES: Institutional Session

SIES: Best Abstracts

SIES: Oral Communications

SIES: Posters