Review Articles


Rare inherited coagulation disorders and thrombosis (356 Online Views)

Massimo Franchini, Samin Mohsenian, Pier Mannuccio Mannucci




Reframing leukemia-niche interactions: the emerging role of the marrow adipocyte lineage (333 Online Views)

Bexultan Kazybay, Mauricio N. Ferrao Blanco, Olaf Heidenreich, Hermann Josef Vormoor


Immune checkpoint therapy in pediatric and adolescent lymphomas (602 Online Views)

David J. Hoogstra, Ana C. Xavier, Paul Harker-Murray, Sarah Alexander, Lisa Giulino-Roth, Teresa A. Hernandez, Mitchell S. Cairo


Prognosis in marginal zone lymphoma: a comprehensive review (1332 Online Views)

Annalisa Talami, Maria Elena Nizzoli, Emilia Cappello, Stefano Luminari, Luca Arcaini




NEAT1: a multifaceted long non-coding RNA in multiple myeloma (2055 Online Views)

Gabriele Benini, Sara Taranto, Margherita Sciumè, Fabio Rigali, Raffaella Marcheselli, Andrea Abate, Stefania Mitola, Sandra Sigala, Antonio Sacco, Aldo M. Roccaro


JAK inhibitor selection in challenging scenarios of myelofibrosis: a review (6988 Online Views)

Pankit Vachhani, Ruben Mesa, John Mascarenhas, Raajit Rampal, Stephen T. Oh, Alessandro Maria Vannucchi, Maria Laura Fox, Francesca Palandri, Francesco Passamonti, Jean-Jacques Kiladjian, Mahshid Azimi, Claire Harrison, Prithviraj Bose




CHIP ahoy: charting a decade of discovery in clonal hematopoiesis (4363 Online Views)

Casey K. Wong, Alexandra McDonald, Marco M. Buttigieg, Michael J. Rauh




Treatment-related mutagenic processes in acute lymphoblastic leukemia (3521 Online Views)

Cédric G. van der Ham, Frank N. van Leeuwen, Roland P. Kuiper



Asparaginase-associated hyperammonemia (6408 Online Views)

Raheel Altaf Raja, Bodil Als-Nielsen, Allan M. Lund, Hendrik Vilstrup, Kim Peder Dalhoff, Kjeld Schmiegelow


Global estimation of the bleeding episodes treatable with desmopressin in von Willebrand disease and hemophilia A (5109 Online Views)

Alessandro Gringeri, Pier Mannuccio Mannucci, Michele Gringeri, Giancarlo Castaman, Flora Peyvandi







Clinical and laboratory risk factors for sickle cell retinopathy and maculopathy: a scoping review of the current evidence (3856 Online Views)

Rajani P. Brandsen, Roselie M.H. Diederen, Gizem Kocabas, Erfan Nur, Arjan Malekzadeh, Reinier O. Schlingemann, Bart J. Biemond


Infections in sickle cell disease (31809 Online Views)

Lily E.A. Scourfield, Amina Nardo-Marino, Thomas N. Williams, David C. Rees


Resistance to immunomodulatory drugs in multiple myeloma: the cereblon pathway and beyond (8517 Online Views)

Phaik Ju Teoh, Mun Yee Koh, Constantine Mitsiades, Sarah Gooding, Wee Joo Chng







Germline variants in acquired aplastic anemia: current knowledge and future perspectives (10417 Online Views)

Peicheng Wang, Wanzhi Jiang, Tianyi Lai, Qi Liu, Yingying Shen, Baodong Ye, Dijiong Wu


Epigenetic regulation of megakaryopoiesis and platelet formation (7894 Online Views)

Baichuan Xu, Xianpeng Ye, Zhaoyang Wen, Shilei Chen, Junping Wang




Health-related quality of life in patients with hematologic malignancies treated with chimeric antigen receptor T-cell therapy: review and current progress (5400 Online Views)

Emmanuelle Tchernonog, Aline Moignet, Amélie Anota, Sophie Bernard, Guy Bouguet, Fanny Colin, Catherine Rioufol, Loïc Ysebaert, Emmanuel Gyan


CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis (7899 Online Views)

Gael Vermeersch, Paul Proost, Sofie Struyf, Mieke Gouwy, Timothy Devos




Emicizumab: the hemophilia A game-changer (22148 Online Views)

Pedro E. Alcedo Andrade, Pier Mannuccio Mannucci, Craig M. Kessler


How we manage a high D-dimer (246888 Online Views)

Massimo Franchini, Daniele Focosi, Mario Piergiulio Pezzo, Pier Mannuccio Mannucci



Clinical perspectives on the optimal use of lenalidomide plus bortezomib and dexamethasone for the treatment of newly diagnosed multiple myeloma (7997 Online Views)

Paul G. Richardson, Brian G. Durie, Laura Rosiñol, Maria-Victoria Mateos, Angela Dispenzieri, Philippe Moreau, Shaji Kumar, Noopur Raje, Nikhil Munshi, Jacob P. Laubach, Peter O’Gorman, Elizabeth O’Donnell, Peter Voorhees, Thierry Facon, Joan Bladé, Sagar Lonial, Aurore Perrot, Kenneth C. Anderson



Down syndrome and leukemia: from basic mechanisms to clinical advances (14119 Online Views)

André Baruchel, Jean-Pierre Bourquin, John Crispino, Sergi Cuartero, Henrik Hasle, Johann Hitzler, Jan-Henning Klusmann, Shai Izraeli, Andrew A. Lane, Sébastien Malinge, Karen R. Rabin, Irene Roberts, Sandra Ryeom, Sarah K. Tasian, Elvin Wagenblast




Shwachman-Diamond syndromes: clinical, genetic, and biochemical insights from the rare variants (14759 Online Views)

Nozomu Kawashima, Usua Oyarbide, Marco Cipolli, Valentino Bezzerri, Seth J. Corey







How we manage cardiovascular disease in patients with hemophilia (8539 Online Views)

Massimo Franchini, Daniele Focosi, Pier Mannuccio Mannucci



Biosimilars in rare diseases: a focus on paroxysmal nocturnal hemoglobinuria (4574 Online Views)

Austin Kulasekararaj, Robert Brodsky, Alexander Kulagin, Jun Ho Jang


Prevention and management of secondary central nervous system lymphoma (32510 Online Views)

Sabela Bobillo, Jahanzaib Khwaja, Andrés J.M. Ferreri, Kate Cwynarski


Animal models of Diamond-Blackfan anemia: updates and challenges (7951 Online Views)

Y. Lucy Liu, Aya Shibuya, Bert Glader, Mark C. Wilkes, Maria Barna, Kathleen M. Sakamoto




IgM monoclonal gammopathies of clinical significance: diagnosis and management (23552 Online Views)

Jahanzaib Khwaja, Shirley D’Sa, Monique C. Minnema, Marie José Kersten, Ashutosh Wechalekar, Josephine M. Vos






Interactions of adenoviruses with platelets and coagulation and the vaccine-induced immune thrombotic thrombocytopenia syndrome (6583 Online Views)

Paolo Gresele, Stefania Momi, Rossella Marcucci, Francesco Ramundo, Valerio De Stefano, Armando Tripodi




2021 European Myeloma Network review and consensus statement on smoldering multiple myeloma: how to distinguish (and manage) Dr. Jekyll and Mr. Hyde (14556 Online Views)

Pellegrino Musto, Monika Engelhardt, Jo Caers, Niccolo’ Bolli, Martin Kaiser, Niels van de Donk, Evangelos Terpos, Annemiek Broijl, Carlos Fernández de Larrea, Francesca Gay, Hartmut Goldschmidt, Roman Hajek, Annette Juul Vangsted, Elena Zamagni, Sonja Zweegman, Michele Cavo, Meletios Dimopoulos, Hermann Einsele, Heinz Ludwig, Giovanni Barosi, Mario Boccadoro, Maria-Victoria Mateos, Pieter Sonneveld, Jesus San Miguel


Novel immunotherapies in multiple myeloma – chances and challenges (5598 Online Views)

Leo Rasche, Ralph Wäsch, Markus Munder, Hartmut Goldschmidt, Marc S. Raab



Targeting the tumor microenvironment in chronic lymphocytic leukemia (9270 Online Views)

Rebecka Svanberg, Sine Janum, Piers E.M. Patten, Alan G. Ramsay, Carsten U. Niemann



The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance (8237 Online Views)

Yasith Mathangasinghe, Bruno Fauvet, Stephen M. Jane, Pierre Goloubinoff, Nadinath B. Nillegoda



European Myeloma Network perspective on CAR T-Cell therapies for multiple myeloma (11299 Online Views)

Benedetto Bruno, Ralph Wäsch, Monika Engelhardt, Francesca Gay, Luisa Giaccone, Mattia D’Agostino, Luis-Gerardo Rodríguez-Lobato, Sophia Danhof, Nico Gagelmann, Nicolaus Kröger, Rakesh Popat, Niels W.C.J. van de Donk, Evangelos Terpos, Meletios A. Dimopoulos, Pieter Sonneveld, Hermann Einsele, Mario Boccadoro



T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective (9094 Online Views)

Fleur S. Peters, Jonathan C. Strefford, Eric Eldering, Arnon P. Kater


Chronic organ injuries in children with sickle cell disease (5743 Online Views)

Slimane Allali, Melissa Taylor, Joséphine Brice, Mariane de Montalembert



Latest culture techniques: cracking the secrets of bone marrow to mass-produce erythrocytes and platelets ex vivo (11021 Online Views)

Christian A. Di Buduo, Alicia Aguilar, Paolo M. Soprano, Alberto Bocconi, Carolina P. Miguel, Giovanna Mantica, Alessandra Balduini













Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding (7111 Online Views)

Alicia Veninga, Ilaria De Simone, Johan W.M. Heemskerk, Hugo ten Cate, Paola E.J. van der Meijden





Multiple myeloma with central nervous system relapse (26298 Online Views)

Philip A. Egan, Patrick T Elder, W. Ian Deighan, Sheila J.M. O’Connor, H. Denis Alexander


Geriatric assessment in older patients with a hematologic malignancy: a systematic review (9489 Online Views)

Ellen R.M. Scheepers, Ariel M. Vondeling, Noortje Thielen, René van der Griend, Reinhard Stauder, Marije E. Hamaker






How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies (5133 Online Views)

David Wu, Xi Luo, Simone Feurstein, Chimene Kesserwan, Shruthi Mohan, Daniel E. Pineda-Alvarez, Lucy A. Godley, on behalf of the collaborative group of the American Society of Hematology - Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel


Glanzmann thrombasthenia: genetic basis and clinical correlates (36567 Online Views)

Juliana Perez Botero, Kristy Lee, Brian R Branchford, Paul F Bray, Kathleen Freson, Michele P. Lambert, Minjie Luo, Shruthi Mohan, Justyne E. Ross, Wolfgang Bergmeier, Jorge Di Paola


The variable manifestations of disease in pyruvate kinase deficiency and their management (38315 Online Views)

Hanny Al-Samkari, Eduard J. van Beers, Kevin H.M. Kuo, Wilma Barcellini, Paola Bianchi, Andreas Glenthøj, María del Mar Mañú Pereira, Richard van Wijk, Bertil Glader, Rachael F. Grace


An international registry of patients with plasminogen deficiency (HISTORY) (8247 Online Views)

Amy D. Shapiro, Marzia Menegatti, Roberta Palla, Marco Boscarino, Christopher Roberson, Paolo Lanzi, Joel Bowen, Charles Nakar, Isaac A. Janson, Flora Peyvandi


Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management (29416 Online Views)

Pasquale Pignatelli, Evaristo Ettorre, Danilo Menichelli, Arianna Pani, Francesco Violi, Daniele Pastori


Innate immune cells, major protagonists of sickle cell disease pathophysiology (8052 Online Views)

Slimane Allali, Thiago Trovati Maciel, Olivier Hermine, Mariane de Montalembert


Fibrin(ogen) in human disease: both friend and foe (111287 Online Views)

Rui Vilar, Richard J. Fish, Alessandro Casini, Marguerite Neerman-Arbez




MYD88 in the driver’s seat of B-cell lymphomagenesis: from molecular mechanisms to clinical implications (14262 Online Views)

Ruben A.L. de Groen, Anne M.R. Schrader, Marie José Kersten, Steven T. Pals, Joost S.P. Vermaat






Updates on the hematologic tumor microenvironment and its therapeutic targeting (5573 Online Views)

Dorian Forte, Daniela S. Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer








Thrombopoietin receptor agonists: ten years later (58326 Online Views)

Waleed Ghanima, Nichola Cooper, Francesco Rodeghiero, Bertrand Godeau, James B. Bussel




CRISPR to fix bad blood: a new tool in basic and clinical hematology (13008 Online Views)

Elisa González-Romero, Cristina Martínez-Valiente, Cristian García-Ruiz, Rafael P. Vázquez-Manrique, José Cervera, Alejandra Sanjuan-Pla



State-of-the-art review: allogeneic stem cell transplantation for myelofibrosis in 2019 (13538 Online Views)

Donal P. McLornan, Ibrahim Yakoub-Agha, Marie Robin, Yves Chalandon, Claire N. Harrison, Nicolaus Kroger



IgG4-related disease: what a hematologist needs to know (379616 Online Views)

Luke Y.C. Chen, Andre Mattman, Michael A. Seidman, Mollie N. Carruthers


CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies (13358 Online Views)

Lucia Prieto-Torres, Socorro M. Rodriguez-Pinilla, Arantza Onaindia, Mariano Ara, Luis Requena, Miguel Á. Piris






TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics (24673 Online Views)

Elias Campo, Florence Cymbalista, Paolo Ghia, Ulrich Jäger, Sarka Pospisilova, Richard Rosenquist, Anna Schuh, Stephan Stilgenbauer


Preclinical human models and emerging therapeutics for advanced systemic mastocytosis (8872 Online Views)

Michel Arock, Ghaith Wedeh, Gregor Hoermann, Siham Bibi, Cem Akin, Barbara Peter, Karoline V. Gleixner, Karin Hartmann, Joseph H. Butterfield, Dean D. Metcalfe, Peter Valent



Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts (23387 Online Views)

Peter Valent, Guntram Büsche, Igor Theurl, Iris Z. Uras, Ulrich Germing, Reinhard Stauder, Karl Sotlar, Wolfgang Füreder, Peter Bettelheim, Michael Pfeilstöcker, Rainer Oberbauer, Wolfgang R. Sperr, Klaus Geissler, Jürg Schwaller, Richard Moriggl, Marie C. Béné, Ulrich Jäger, Hans-Peter Horny, Olivier Hermine


Cardiovascular adverse events in modern myeloma therapy – Incidence and risks. A review from the European Myeloma Network (EMN) and Italian Society of Arterial Hypertension (SIIA) (8390 Online Views)

Sara Bringhen, Alberto Milan, Claudio Ferri, Ralph Wäsch, Francesca Gay, Alessandra Larocca, Marco Salvini, Evangelos Terpos, Hartmut Goldschmidt, Michele Cavo, Maria Teresa Petrucci, Heinz Ludwig, Holger W. Auner, Jo Caers, Martin Gramatzki, Mario Boccadoro, Hermann Einsele, Pieter Sonneveld, Monika Engelhardt




Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers (5508 Online Views)

Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo





From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives (10275 Online Views)

Francesca Gay, Monika Engelhardt, Evangelos Terpos, Ralph Wäsch, Luisa Giaccone, Holger W. Auner, Jo Caers, Martin Gramatzki, Niels van de Donk, Stefania Oliva, Elena Zamagni, Laurent Garderet, Christian Straka, Roman Hajek, Heinz Ludwig, Herman Einsele, Meletios Dimopoulos, Mario Boccadoro, Nicolaus Kröger, Michele Cavo, Hartmut Goldschmidt, Benedetto Bruno, Pieter Sonneveld


The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source (9762 Online Views)

Barnaby Peacock-Young, Fraser L. Macrae, Darren J. Newton, Anita Hill, Robert A S Ariëns








Is immunotherapy here to stay in multiple myeloma? (4771 Online Views)

Paula Rodríguez-Otero, Bruno Paiva, Monika Engelhardt, Felipe Prósper, Jesús F. San Miguel


Propagation of thrombosis by neutrophils and extracellular nucleosome networks (5779 Online Views)

Susanne Pfeiler, Konstantin Stark, Steffen Massberg, Bernd Engelmann



Anti-thymocyte globulin as graft-versus-host disease prevention in the setting of allogeneic peripheral blood stem cell transplantation: a review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (6697 Online Views)

Frédéric Baron, Mohamad Mohty, Didier Blaise, Gérard Socié, Myriam Labopin, Jordi Esteve, Fabio Ciceri, Sebastian Giebel, Norbert Claude Gorin, Bipin N Savani, Christoph Schmid, Arnon Nagler



The emerging role of immune checkpoint inhibition in malignant lymphoma (4821 Online Views)

Ida Hude, Stephanie Sasse, Andreas Engert, Paul J. Bröckelmann



The myeloma stem cell concept, revisited: from phenomenology to operational terms (7784 Online Views)

Hans Erik Johnsen, Martin Bøgsted, Alexander Schmitz, Julie Støve Bødker, Tarec Christoffer El-Galaly, Preben Johansen, Peter Valent, Niklas Zojer, Els Van Valckenborgh, Karin Vanderkerken, Mark van Duin, Pieter Sonneveld, Martin Perez-Andres, Alberto Orfao, Karen Dybkær


‘Trained immunity’: consequences for lymphoid malignancies (4972 Online Views)

Wendy B.C. Stevens, Mihai G. Netea, Arnon P. Kater, Walter J.F.M. van der Velden


New insights on hereditary erythrocyte membrane defects (17469 Online Views)

Immacolata Andolfo, Roberta Russo, Antonella Gambale, Achille Iolascon


Osteonecrosis in children with acute lymphoblastic leukemia (7961 Online Views)

Marina Kunstreich, Sebastian Kummer, Hans-Juergen Laws, Arndt Borkhardt, Michaela Kuhlen



Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice (11100 Online Views)

Celalettin Ustun, Michel Arock, Hanneke C. Kluin-Nelemans, Andreas Reiter, Wolfgang R. Sperr, Tracy George, Hans-Peter Horny, Karin Hartmann, Karl Sotlar, Gandhi Damaj, Olivier Hermine, Srdan Verstovsek, Dean D. Metcalfe, Jason Gotlib, Cem Akin, Peter Valent


Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond (4879 Online Views)

Richard Rosenquist, Andreas Rosenwald, Ming-Qing Du, Gianluca Gaidano, Patricia Groenen, Andrew Wotherspoon, Paolo Ghia, Philippe Gaulard, Elias Campo, Kostas Stamatopoulos






Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies (23873 Online Views)

Abdallah Abou Zahr, Mohamed E. Salama, Nicole Carreau, Douglas Tremblay, Srdan Verstovsek, Ruben Mesa, Ronald Hoffman, John Mascarenhas





Role of the tumor microenvironment in mature B-cell lymphoid malignancies (10280 Online Views)

Nathan H. Fowler, Chan Yoon Cheah, Randy D. Gascoyne, John Gribben, Sattva S. Neelapu, Paolo Ghia, Catherine Bollard, Stephen Ansell, Michael Curran, Wyndham H. Wilson, Susan O’Brien, Cliona Grant, Richard Little, Thorsten Zenz, Loretta J. Nastoupil, Kieron Dunleavy


Chronic myeloid leukemia: reminiscences and dreams (18576 Online Views)

Tariq I. Mughal, Jerald P. Radich, Michael W. Deininger, Jane F. Apperley, Timothy P. Hughes, Christine J. Harrison, Carlo Gambacorti-Passerini, Giuseppe Saglio, Jorge Cortes, George Q. Daley






Risk factors for relapse after allogeneic transplantation in acute myeloid leukemia (4693 Online Views)

Gert J. Ossenkoppele, Jeroen J.W.M. Janssen, Arjan A. van de Loosdrecht


Humanized hemato-lymphoid system mice (8681 Online Views)

Alexandre P.A. Theocharides, Anthony Rongvaux, Kristin Fritsch, Richard A. Flavell, Markus G. Manz






Environmental determinants of severity in sickle cell disease (17166 Online Views)

Sanjay Tewari, Valentine Brousse, Frédéric B. Piel, Stephan Menzel, David C. Rees







Epigenetics in the hematologic malignancies (5406 Online Views)

Chun Yew Fong, Jessica Morison, Mark A. Dawson






Survival analysis in hematologic malignancies: recommendations for clinicians (6231 Online Views)

Julio Delgado, Arturo Pereira, Neus Villamor, Armando López-Guillermo, Ciril Rozman


Early lymphoid lesions: conceptual, diagnostic and clinical challenges (10840 Online Views)

Karthik A. Ganapathi, Stefania Pittaluga, Oreofe O. Odejide, Arnold S. Freedman, Elaine S. Jaffe



The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy (6508 Online Views)

Graham Packham, Serge Krysov, Alex Allen, Natalia Savelyeva, Andrew J. Steele, Francesco Forconi, Freda K. Stevenson




Heme and erythropoieis: more than a structural role (22701 Online Views)

Deborah Chiabrando, Sonia Mercurio, Emanuela Tolosano


Nature and importance of follicular lymphoma precursors (5700 Online Views)

Emilie Mamessier, Florence Broussais-Guillaumot, Bruno Chetaille, Reda Bouabdallah, Luc Xerri, Elaine S. Jaffe, Bertrand Nadel


Why methylation is not a marker predictive of response to hypomethylating agents (4685 Online Views)

Maria Teresa Voso, Valeria Santini, Emiliano Fabiani, Luana Fianchi, Marianna Criscuolo, Giulia Falconi, Francesco Guidi, Stefan Hohaus, Giuseppe Leone


Primary thrombocytosis in children (20631 Online Views)

Nicole Kucine, Katherine M. Chastain, Michelle B. Mahler, James B. Bussel



Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy (6799 Online Views)

Siham Bibi, Melis Dilara Arslanhan, Florent Langenfeld, Sylvie Jeanningros, Sabine Cerny-Reiterer, Emir Hadzijusufovic, Luba Tchertanov, Richard Moriggl, Peter Valent, Michel Arock


Management and treatment of osteonecrosis in children and adolescents with acute lymphoblastic leukemia (5721 Online Views)

Mariël L. te Winkel, Rob Pieters, Ernst-Jan D. Wind, J.H.J.M. (Gert) Bessems, Marry M. van den Heuvel-Eibrink


Measurement of adherence to BCR-ABL inhibitor therapy in chronic myeloid leukemia: current situation and future challenges (7132 Online Views)

Lucien Noens, Marja Hensen, Izabela Kucmin-Bemelmans, Christina Lofgren, Isabelle Gilloteau, Bernard Vrijens


B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies (6373 Online Views)

José P. Vaqué, Nerea Martínez, Ana Batlle-López, Cristina Pérez, Santiago Montes-Moreno, Margarita Sánchez-Beato, Miguel A. Piris


Update on treatment of light chain amyloidosis (9930 Online Views)

Shameem Mahmood, Giovanni Palladini, Vaishali Sanchorawala, Ashutosh Wechalekar


Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies (4802 Online Views)

Elias Jabbour, Oliver G. Ottmann, Michael Deininger, Andreas Hochhaus



Advances in myelofibrosis: a clinical case approach (7462 Online Views)

John O. Mascarenhas, Attilio Orazi, Kapil N. Bhalla, Richard E. Champlin, Claire Harrison, Ronald Hoffman


Autophagy in blood cancers: biological role and therapeutic implications (7158 Online Views)

Alessio Nencioni, Michele Cea, Fabrizio Montecucco, Valter D. Longo, Franco Patrone, Angelo M. Carella, Tessa L. Holyoake, G. Vignir Helgason


Management recommendations for chronic myelomonocytic leukemia: consensus statements from the SIE, SIES, GITMO groups (5437 Online Views)

Francesco Onida, Giovanni Barosi, Giuseppe Leone, Luca Malcovati, Enrica Morra, Valeria Santini, Giorgina Specchia, Sante Tura



Classical Hodgkin’s lymphoma: the Lymphoma Study Association guidelines for relapsed and refractory adult patients eligible for transplant (6492 Online Views)

Eric Van Den Neste, Olivier Casasnovas, Marc André, Mohamed Touati, Delphine Senecal, Véronique Edeline, Aspasia Stamatoullas, Luc Fornecker, Bénédicte Deau, Thomas Gastinne, Oumédaly Reman, Isabelle Gaillard, Cécile Borel, Pauline Brice, Christophe Fermé



Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma: a consensus project of the EBMT-Lymphoma Working Party (5043 Online Views)

Silvia Montoto, Paolo Corradini, Martin Dreyling, Michele Ghielmini, Eva Kimby, Armando López-Guillermo, Stephen Mackinnon, Robert E. Marcus, Gilles Salles, Harry C Schouten, Anna Sureda, Peter Dreger


Non-transfusion-dependent thalassemias (17419 Online Views)

Khaled M. Musallam, Stefano Rivella, Elliott Vichinsky, Eliezer A. Rachmilewitz


Iron refractory iron deficiency anemia (14798 Online Views)

Luigia De Falco, Mayka Sanchez, Laura Silvestri, Caroline Kannengiesser, Martina U. Muckenthaler, Achille Iolascon, Laurent Gouya, Clara Camaschella, Carole Beaumont



Clinical implications of the molecular genetics of chronic lymphocytic leukemia (3534 Online Views)

Robin Foà, Ilaria Del Giudice, Anna Guarini, Davide Rossi, Gianluca Gaidano


Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3) (21548 Online Views)

Anna Skiada, Fanny Lanternier, Andreas H. Groll, Livio Pagano, Stephan Zimmerli, Raoul Herbrecht, Olivier Lortholary, George L. Petrikkos





Infections in myelodysplastic syndromes (12009 Online Views)

Andréa Toma, Pierre Fenaux, François Dreyfus, Catherine Cordonnier


Molecular pathogenesis of Waldenström’s macroglobulinemia (4985 Online Views)

Esteban Braggio, Casey Philipsborn, Anne Novak, Lucy Hodge, Stephen Ansell, Rafael Fonseca




Acute myeloid leukemia developing in patients with autoimmune diseases (8825 Online Views)

Safaa M. Ramadan, Tamer M Fouad, Valentina Summa, Syed KH Hasan, Francesco Lo-Coco


Thrombolytic therapy for central venous catheter occlusion (14338 Online Views)

Jacquelyn L. Baskin, Ulrike Reiss, Judith A. Wilimas, Monika L. Metzger, Raul C. Ribeiro, Ching-Hon Pui, Scott C. Howard





An overview of the progress on double umbilical cord blood transplantation (4310 Online Views)

Anastasia Sideri, Nikolaos Neokleous, Philippe Brunet De La Grange, Bernadette Guerton, Marie-Caroline Le Bousse Kerdilles, Georges Uzan, Corina Peste-Tsilimidos, Eliane Gluckman




Chronic lymphocytic leukemia and autoimmunity: a systematic review (18230 Online Views)

Kate Hodgson, Gerardo Ferrer, Emili Montserrat, Carol Moreno


The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues (3519 Online Views)

Richard A. Van Etten, Steffen Koschmieder, Francois Delhommeau, Danilo Perrotti, Tessa Holyoake, Animesh Pardanani, Ruben Mesa, Tony Green, Amr R. Ibrahim, Tariq Mughal, Robert Peter Gale, John Goldman


The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disorders (8388 Online Views)

Anna Merlo, Riccardo Turrini, Riccardo Dolcetti, Debora Martorelli, Elena Muraro, Patrizia Comoli, Antonio Rosato



PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers (9107 Online Views)

Laurent Brault, Christelle Gasser, Franz Bracher, Kilian Huber, Stefan Knapp, Jürg Schwaller


Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia (11657 Online Views)

Sophie Park, Nicolas Chapuis, Jérôme Tamburini, Valérie Bardet, Pascale Cornillet-Lefebvre, Lise Willems, Alexa Green, Patrick Mayeux, Catherine Lacombe, Didier Bouscary



Lymphoma stem cells: enough evidence to support their existence? (4385 Online Views)

Jose A. Martinez-Climent, Lorena Fontan, Randy D. Gascoyne, Reiner Siebert, Felipe Prosper


Anti-CD20 monoclonal antibodies: historical and future perspectives (7455 Online Views)

Sean H. Lim, Stephen A. Beers, Ruth R. French, Peter W.M. Johnson, Martin J. Glennie, Mark S. Cragg


Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies (6442 Online Views)

Sigurdur Y. Kristinsson, Lynn R. Goldin, Magnus Björkholm, Jill Koshiol, Ingemar Turesson, Ola Landgren




Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis (5948 Online Views)

Andrew J. Ramsay, John D. Hooper, Alicia R. Folgueras, Gloria Velasco, Carlos López-Otín


Platelet receptors and signaling in the dynamics of thrombus formation (15611 Online Views)

José Rivera, María Luisa Lozano, Leyre Navarro-Núñez, Vicente Vicente



Mesenchymal stem cells: the fibroblasts’ new clothes? (6664 Online Views)

Muzlifah A. Haniffa, Matthew P. Collin, Christopher D. Buckley, Francesco Dazzi