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Article
Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
During infection neuraminidase desialylates platelets and induces their rapid clearance from the circulation. Desialylation of O-glycans in GPIbα triggers a series of events resulting in exposure of β-galactoses on N-glycans of many glycoproteins, which are recognized by the Ashwell-Morell receptor on the surface of liver macrophages and hepatocytes.
Article
Targeted genotyping of circulating tumor DNA for classical Hodgkin lymphoma monitoring: a prospective study
Using a next-generation sequencing panel for nine genes commonly mutated in classical Hodgkin lymphoma, this study of 60 patients suggested that the assessment of somatic mutations in circulating tumor DNA is suitable as a biomarker for both diagnosis and evaluation of therapeutic response.
Article
Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study
This study evaluated the clinical utility of genomic arrays for copy-number alterations in chronic lymphocytic leukemia. Analysis of 2,293 arrays from 13 diagnostic laboratories revealed that genomic array is an accurate tool for risk stratification. In particular, high genomic complexity emerged as an independent adverse prognosticator in chronic lymphocytic leukemia.
Article
Preclinical development of a humanized chimeric antigen receptor against B cell maturation antigen for multiple myeloma
B-cell maturation antigen (BCMA) is a promising antigen to target using immunotherapy, including chimeric antigen receptor (CAR) T cells. The authors of this study generated clinical-grade murine CAR T cells directed against BCMA, setting the bases for the implementation of a clinical trial.
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