CURRENT ISSUE
January, 2026
No. 111 (1)
2024 Impact Factor: 7.9
2024 Journal Citation Indicator: 1.9
2024 CiteScore: 11.3
2024 Journal Citation Indicator: 1.9
2024 CiteScore: 11.3
EDITOR'S PICKS
Review Series CELEBRATING THE CENTENARY OF VON WILLEBRAND DISEASE
Introduction to the Review Series. A century after Erik von Willebrand
Structure and multiple functions of von Willebrand factor
Von Willebrand disease: classification and epidemiology
Clinical and laboratory diagnosis of von Willebrand disease
Molecular genetic testing in von Willebrand disease: past, present, and beyond
Historical, current and future treatments for von Willebrand disease
Gynecologic and obstetric management of girls and women with von Willebrand disease
ARTICLES IN THREE SENTENCES
Article
PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia
Human PHD finger protein 6 (PHF6) is a nuclear and nucleolar protein involved in transcriptional regulation and a partner of the LIM domain only 2 (LMO2) transcriptional complex central to T-cell acute lymphoblastic leukemia (T-ALL) biology.The new study by Stanulović and colleagues shows that PHF6 physically associates with LMO2 and binds DNA T-ALL cells, pointing to a direct regulatory role. This interaction shapes the expression of key hematopoietic genes such as SPI1, suggesting that PHF6 contributes to T-ALL pathogenesis by modulating critical transcriptional networks.
Article
CD6 expression is an independent predictor of time to first treatment in chronic lymphocytic leukemia
CD6 is a type I transmembrane glycoprotein expressed by B-cell neoplasms but its role in signal transduction is still a subject of debate. Carrillo-Serradell and colleagues, using RNA-sequencing data, evaluated the potential biological role and clinical performance of differential CD6 expression in a cohort of patients with chronic lymphocytic leukemia (CLL). The results showed that CD6 plays a pivotal role in CLL biology and is an independent predictor of time to first treatment in CLL.
Article
Single-cell RNA sequencing reveals heterogeneity of mucosaassociated invariant T cells in donor grafts and its diagnostic relevance in gastrointestinal graft-versus-host disease
Mucosa-associated invariant T (MAIT) cells play an emerging role in immune responses after allogeneic hematopoietic stem-cell transplantation, particularly in the context of gastrointestinal graft-versus-host disease (GI-GvHD). In this study, Gao and colleagues used single-cell RNA sequencing to characterize the heterogeneity of MAIT cells within G-CSF–mobilized donor grafts and to define their functional states. They found distinct MAIT subsets with immunoregulatory and tissue-repair signatures, identifying CXCR6⁺ populations as strong predictors of GI-GVHD risk prior to transplantation.
Letter
Metallothionein 1 mediates growth and survival of Dnmt3a;Npm1-mutant acute myeloid leukemia
Acute myeloid leukemia (AML) driven by co-occurring DNMT3A and NPM1 mutations represents a genetically defined subset. In this study, Colom Díaz and colleagues investigated the role of metallothionein 1 (MT1), a low molecular weight, cysteine-rich intracellular protein, in supporting the growth and viability of Dnmt3a;Npm1-mutant AML cells using preclinical models. They found that MT1 is essential for leukemia cell proliferation and survival, suggesting that targeting MT1 may represent a novel therapeutic target.
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