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Articles
XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia
Terminal erythroid maturation requires that the chaperone Heat Shock Protein 70 (HSP70) accumulates in the nucleus. This is inhibited in human β-thalassemia major erythroblasts due to HSP70 sequestration by free α-globin chains. This study demonstrated that treatment of β−thalassemic erythroblasts with an exportin-1 inhibitor increases the amount of nuclear HSP70 and improves their terminal differentiation.
Articles
Prognostic impact of somatic mutations in diffuse large B-cell lymphoma and relationship to cell-of-origin: data from the phase III GOYA study
The authors characterized the mutational profile of diffuse large B-cell lymphoma and evaluated the prognostic impact of somatic mutations in 499 patients. Only alterations in BCL2 were significantly associated with clinical outcome independently of cell of origin and clinical factors.
Articles
RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS
This study analyzed the functional effects of abrogation of RAL, a member of the RAS superfamily of small GTPases, in myeloma cell lines and found that it is a critical mediator of survival independently of oncogenic RAS. Combining RAL depletion with clinically relevant anti-myeloma agents led to enhanced rates of cell death. Thus, RAL represents a potential therapeutic target in its own right.
Letters to the Editor
Mortality in children with sickle cell disease in mainland France from 2000 to 2015
This study investigated 4682 babies with sickle cell disease contributing to 35291 person-years of follow-up. Death incidence rate was 0.16 per 100 person-years, with infection as the leading cause of death and acute splenic sequestration as the second cause. Better empowerment of families and closer monitoring of younger patients are required to further decrease mortality rates.
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