Review Series On Measurable Residual Disease
Measurable residual disease in acute lymphoblastic leukemia: methods and clinical context in adult patients
ARTICLES IN THREE SENTENCES
Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets
The actin cytoskeleton is essential to maintain platelet morphology and for key platelet functions. Thymosin β4 (encoded by Tmsb4x) is one of the two main G-actin-sequestering proteins, and as dynamic actin reorganization is crucial for both platelet biogenesis and function, Scheller and colleagues investigated the role of thymosin β4 in these processes by studying Tmsb4x knockout mice. They demonstrated a critical role for thymosin β4 in actin dynamics during platelet biogenesis, platelet activation and thrombus stability.
Circulating endothelial cells and the study of vascular injury in children undergoing hematopoietic stem cell transplant
Little is known about endothelial injury after pediatric hematopoietic stem cell transplant (HSCT) because blood vessels are hard to observe directly. Sabulski and colleagues prospectively evaluated circulating endothelial cells (CEC) as a biomarker of outcomes after HSCT and endothelial injury. They observed that increased numbers of CEC correlate with endothelial injury. CEC can serve as a liquid biopsy and are a tractable, non-invasive tool to study vascular biology.
Kinetics of early and late molecular recurrences after first-line imatinib cessation in chronic myeloid leukemia: updated results from the STIM2 trial
Discontinuation of tyrosine kinase inhibitors in chronic phase chronic myeloid leukemia is feasible in clinical practice according to recently published international recommendations. However, factors predictive of molecular recurrence have not been fully elucidated. In the current study, Dulucq and colleagues updated results from the STIM2 study and showed that predictive factors differed according to the time of the molecular recurrence.
Mass spectrometry-based proteomics in clinical practice amyloid typing: state-of-the-art from a French nationwide cohort
The identification of the causal protein of amyloid fibrils is fundamental because effective treatments are now available. Traditionally, amyloid typing has been performed using immunofluorescence and immunohistochemistry. In the present study, the authors reported their experience of amyloid typing by laser microdissection combined with tandem mass spectrometry over a 10-year period. Overall, this retrospective study suggests that this technique is the new gold standard for typing amyloidosis.
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