October, 2020

No. 105 (10)

2019 Impact Factor: 7.116

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner

This study investigated the impact of the complex hemodynamics found in stenosed arteries on thrombus formation. It identified a bi-phasic process of thrombus development on immobilized fibrinogen and other weak adhesive surfaces, such as laminins or thrombospondin-1, that relies on von Willebrand factor and occurs specifically under shear rate gradients.

Nicolas Receveur et al.


Myeloproliferative and lymphoproliferative malignancies occurring in the same patient: a nationwide discovery cohort

Myeloid and lymphoid malignancies are postulated to have distinct pathogenic mechanisms. This study identified 599 patients with a myeloproliferative neoplasm and a concomitant or subsequent diagnosis of lymphoma. The authors suggest that a myeloproliferative neoplasm and lymphoproliferative malignancy may have common pathogenic events, possibly already at the progenitor level.

Johanne M. Holst et al.


Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity

Through the generation of a novel humanized zebrafish that expresses key hematopoietic cytokines, this study exploits the previously recognized imaging and higher-throughput screening advantages of the zebrafish model system to create a powerful new preclinical tool. This model can be used to validate anti-leukemic and stem cell expanding therapeutics and for related screening.

Vinothkumar Rajan et al.

Letters to the Editor

HLA-DRB1*11 is a strong risk factor for acquired thrombotic thrombocytopenic purpura in children

Twenty-six children with acquired thrombotic thrombocytopenic purpura (TTP) underwent HLA class II typing. As in adults, HLA-DRB1*11 was identified as a susceptibility factor for TTP. Previous reports showed the association between HLADRB1*11 and other autoimmune diseases, so long-term follow-up of patients with child-onset acquired TTP is required for early detection of other autoimmune diseases.

Bérangère S. Joly et al.