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Spotlight Review Article
Emerging technologies of single-cell multi-omics
ARTICLES IN THREE SENTENCES

Letter
Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation
Spontaneous intracranial hemorrhage (ICH) represents a common complication in patients with brain metastases and, above all, patients who are on anticoagulation because of cardiovascular complications have a 15% incidence of ICH. Hamulyák and colleagues present results of the Anticoagulation in Brain Cancer (ABC) study, aimed to compare rates of ICH among patients with brain metastases treated with oral anticoagulants or low-molecular-weight heparin and evaluate outcomes. The study found no significant difference in ICH risk between the two anticoagulation groups, even after adjusting for confounders.

Case Report
Very long-term remission with azacitidine in VEXAS syndrome
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly identified monogenic disorder. Zhao and colleagues present the case of a VEXAS patient achieving prolonged remission with azacitidine. Given the lack of established treatment guidelines for VEXAS syndrome, further research is needed to determine whether to prioritize treatment on controlling the cytokine storm (steroids, JAK inhibitors, or anti-interleukin agents) or on targeting the mutated clone (azacitidine or even in some cases allogeneic hematopoietic stem cell transplantation) and to determine the optimal scheduling for these approaches.

Article
Characterization of tumor microenvironment and cell interaction patterns in testicular and diffuse large B-cell lymphomas
The tumor microenvironment (TME) of diffuse large B-cell Lymphoma (DlBCL), not otherwise specified, is poorly characterized. Autio and colleagues dissect the composition and spatial organization of the TME in germinal center B-cell, activated B-cell, and testicular DLBCL using gene expression profiling and multiplex immunohistochemistry. They demonstrate biologically and clinically relevant differences in the composition of and cellular interactions in the TME between various DLBCL entities.

Article
Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy
Little is known about the impact of center-specific variables on outcomes after allogeneic hematopoietic cell transplantation (alloHCT) for acute myeloid leukemia (AML). Bethege and colleagues conducted a study to investigate the effect of center-specific variables on overall survival after alloHCT in AML. Results show that center volume, center experience and university hospital have an impact on alloHCT outcomes in AML in Germany, suggesting efforts to centralize highly specialized therapeutic interventions such as alloHCT in experienced, large volume, high-end care centers.
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