Non-typhoidal Salmonella (NTS) bacteremia is highly prevalent in areas with concurrent malaria endemicity and the association between NTS and malaria has been particularly observed in children with severe malarial anemia (SMA). Abuga et al investigated the relationship between malaria, anemia and NTS in 75,034 children and then estimated levels of hepcidin in children with NTS bacteremia and malaria. SMA was associated with a strongly increased risk of NTS bacteremia and reduced hepcidin levels were observed in children with SMA and SMA+NTS; therefore, the authors hypothesized that reduced hepcidin might contribute to NTS growth by modulating iron availability for bacterial growth.

This multicenter phase I/II study evaluated combination therapy with temsirolimus and lenalidomide (TEM/LEN) in patients with relapsed/refractory lymphomas. The primary endpoints were rates of complete (CR) and overall response (ORR). ORR were 26% (13% CR) for the diffuse large B-cell lymphoma patients, and 80% (35% CR) for classical Hodgkin lymphoma (cHL) patients, most of whom had relapsed after both brentuximab vedotin and autologous stem cell transplantation. Combination therapy with TEM/LEN was feasible and demonstrated encouraging activity in heavily-pretreated lymphomas, particularly in relapsed/refractory cHL.