Early view

Nov 23, 2023

Articles

Massive parallel sequencing unveils homologous recombination deficiency in follicular dendritic cell sarcoma (100 Online Views)

Luisa Lorenzi, Torsten Haferlach, Luigi Mori, Matteo Simbeni, Wencke Walter, Piera Balzarini, Manja Meggendorfer, Claudia Döring, Silvia Lonardi, Mattia Bugatti, Claudio Agostinelli, Jay Mehta, Anita Borges, Abbas Agaimy, Ingrid Simonitsch-Klupp, José Cabeçadas, Elias Campo, Stefano Aldo Pileri, Fabio Facchetti, Martin Leo Hansmann, Sylvia Hartmann

https://doi.org/10.3324/haematol.2023.283669

Nov 16, 2023

Editorials
Article

Autologous-allogeneic versus autologous tandem stem cell transplantation and maintenance therapy with thalidomide for multiple myeloma patients less than 60 years of age: a prospective phase II study (444 Online Views)

Nicolaus Kröger, Gerald Wulf, Ute Hegenbart, Andreas Burchert, Matthias Stelljes, Nico Gagelmann, Arne Brecht, Martin Kaufmann, Lutz Müller, Arnold Ganser, Dominik Wolf, Wolfgang Bethge, Martin Bornhäuser, Michael Kiehl, Eva-Maria Wagner, Christoph Schmid, Hans Christian Reinhardt, Guido Kobbe, Hans Salwender, Thomas Heinicke, Martin Kropff, Marion Heinzelmann, Francis Ayuk, Lorenz Trümper, Andreas Neubauer, Andreas Völp, Evgeny Kluychnikov, Stefan Schönland, Christine Wolschke

https://doi.org/10.3324/haematol.2023.282920

Editorials
Article

Outcomes of limited stage primary bone diffuse large B-cell lymphoma in the rituximab era: a multicenter, retrospective study (287 Online Views)

Alexandra Rezazadeh, Aniko Szabo, Arushi Khurana, David J. Inwards, Matthew A. Lunning, Nancy L. Bartlett, Paolo F. Caimi, Thomas D. Rodgers, Paul M. Barr, Sayan Mullick Chowdhury, Narendranath Epperla, Hiruni Mendries, Brian T. Hill, Timothy S. Oh, Reem Karmali, Julie E. Chang, Gaurav Goyal, Benjamin M. Parsons, Krista M. Isaac, Craig A. Portell, Kathleen Monahan, Malika Siker, David M. King, Timothy S. Fenske

https://doi.org/10.3324/haematol.2023.283210

Editorials
Article

Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders (820 Online Views)

Eily Cournoyer, Justin Ferrell, Susan Sharp, Anish Ray, Michael Jordan, Christopher Dandoy, Michael Grimley, Somak Roy, Robert Lorsbach, Arnold C. Merrow, Adam Nelson, Allison Bartlett, Jennifer Picarsic, Ashish Kumar

https://doi.org/10.3324/haematol.2023.283295

Articles

STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia (81 Online Views)

C. Cameron Yin, Wayne Tam, Serena M. Walker, Amandeep Kaur, Madhu M. Ouseph, Wei Xie, Olga K.Weinberg, Peng Li, Zhuang Zuo, Mark J. Routbort, Simon Chen, L. Jeffrey Medeiros, Tracy I George, Attilio Orazi, Daniel A. Arber, Adam Bagg, Robert P. Hasserjian, Sa A. Wang

https://doi.org/10.3324/haematol.2023.284311

A prospective, multicenter study on hematopoietic stem-cell mobilization with cyclophosphamide plus granulocyte colony-stimulating factor and 'on-demand' plerixafor in multiple myeloma patients treated with novel agents (127 Online Views)

Roberto Mina, Maria Teresa Petrucci, Francesca Bonello, Velia Bongarzoni, Riccardo Saccardi, Giuseppe Bertuglia, Andrea Mengarelli, Andrea Spadaro, Chiara Lisi, Paola Curci, Roberto Massimo Lemoli, Stelvio Ballanti, Rita Floris, Luca Cupelli, Patrizia Tosi, Attilio Olivieri, Delia Rota-Scalabrini, Clotilde Cangialosi, Chiara Nozzoli, Barbara Anaclerico, Francesca Fazio, Benedetto Bruno, Katia Mancuso, Paolo Corradini, Giuseppe Milone, Mario Boccadoro

https://doi.org/10.3324/haematol.2023.284023

Germline bi-allelic SH2B3/LNK alteration predisposes to a neonatal juvenile myelomonocytic leukemia-like disorder (134 Online Views)

Chloé Arfeuille, Yoann Vial, Margaux Cadenet, Aurélie Caye-Eude, Odile Fenneteau, Quentin Neven, Adeline A Bonnard, Simone Pizzi, Giovanna Carpentieri, Yline Capri, Katia Girardi, Lucia Pedace, Marina Macchiaiolo, Kamel Boudhar, Monia ben Khaled, Wadih Abou Chahla, Anne Lutun, Mony Fahd, Séverine Drunat, Elisabetta Flex, Jean-Hugues Dalle, Marion Strullu, Franco Locatelli, Marco Tartaglia, Hélène Cavé

https://doi.org/10.3324/haematol.2023.283917

Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma (172 Online Views)

Silvia Marino, Daniela N. Petrusca, Ryan T. Bishop, Judith L. Anderson, Hayley M. Sabol, Cody Ashby, Justin H. Layer, Annamaria Cesarano, Utpal P. Davé, Fabiana Perna, Jesus Delgado-Calle, John M. Chirgwin, G. David Roodman

https://doi.org/10.3324/haematol.2023.283787

Pilot study of lung cancer screening for survivors of Hodgkin lymphoma (93 Online Views)

Rachel Broadbent, Philip Crosbie, Christopher J. Armitage, Ben Taylor, Sean Tenant, Joseph Mercer, John Radford, Kim Linton

https://doi.org/10.3324/haematol.2023.283287

Nov 9, 2023

Articles

Autologous-allogeneic versus autologous tandem stem cell transplantation and maintenance therapy with thalidomide for multiple myeloma patients less than 60 years of age: a prospective phase II study (444 Online Views)

Nicolaus Kröger, Gerald Wulf, Ute Hegenbart, Andreas Burchert, Matthias Stelljes, Nico Gagelmann, Arne Brecht, Martin Kaufmann, Lutz Müller, Arnold Ganser, Dominik Wolf, Wolfgang Bethge, Martin Bornhäuser, Michael Kiehl, Eva-Maria Wagner, Christoph Schmid, Hans Christian Reinhardt, Guido Kobbe, Hans Salwender, Thomas Heinicke, Martin Kropff, Marion Heinzelmann, Francis Ayuk, Lorenz Trümper, Andreas Neubauer, Andreas Völp, Evgeny Kluychnikov, Stefan Schönland, Christine Wolschke

https://doi.org/10.3324/haematol.2023.282920

Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase (382 Online Views)

Danny V. Jeyaraju, Maryam Alapa, Ann Polonskaia, Alberto Risueño, Prakash Subramanyam, Amit Anand, Kaushik Ghosh, Charalampos Kyriakopoulos, Daiane Hemerich, Rose Hurren, Xiaoming Wang, Marcela Gronda, Aarif Ahsan, Hsiling Chiu, Geethu Thomas, Evan F. Lind, Daniel L Menezes, Aaron D. Schimmer, Patrick R. Hagner, Anita Gandhi, Anjan G. Thakurta

https://doi.org/10.3324/haematol.2023.283437

Impaired hemoglobin clearance by sinusoidal endothelium promotes vaso-occlusion and liver injury in sickle cell disease (199 Online Views)

Tomasz W. Kaminski, Omika Katoch, Ziming Li, Corrine B Hanway, Rikesh K Dubey, Adekunle Alagbe, Tomasz Brzoska, Hong Zhang, Prithu Sundd, Gregory J. Kato, Enrico M. Novelli, Tirthadipa Pradhan-Sundd

https://doi.org/10.3324/haematol.2023.283792

Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma (186 Online Views)

Stien De Coninck, Renate De Smedt, Beatrice Lintermans, Lindy Reunes, Hansen J. Kosasih, Alexandra Reekmans, Lauren M. Brown, Nadine Van Roy, Bruno Palhais, Juliette Roels, Malaika Van der Linden, Jo Van Dorpe, Panagiotis Ntziachristos, Frederik W. van Delft, Marc R. Mansour, Tim Pieters, Tim Lammens, Barbara De Moerloose, Charles E. de Bock, Steven Goossens, Pieter Van Vlierberghe

https://doi.org/10.3324/haematol.2023.283981

Letters to the Editor

CD38 expression by plasma cells In extramedullary multiple myeloma (272 Online Views)

Laura Notarfranchi, Fabrizio Accardi, Cristina Mancini, Eugenia Martella, Sabrina Bonomini, Roberta Segreto, Rosanna Vescovini, Anna Benedetta Dalla Palma, Gabriella Sammarelli, Giannalisa Todaro, Paola Storti, Jessica Burroughs-Garcia, Nicolas Thomas Iannozzi, Vincenzo Raimondi, Oxana Lungu, Stefania Ricci, Luisa Craviotto, Nicola Giuliani

https://doi.org/10.3324/haematol.2023.284169

Nov 2, 2023

Editorials
Letter to the Editor

Survival disparities between children and adolescents and young adults for the major subtypes of non-Hodgkin lymphoma in the Netherlands: a large population-based study (268 Online Views)

Maya Schulpen, Auke Beishuizen, Martine E. D. Chamuleau, Avinash G. Dinmohamed, Friederike A. G. Meyer-Wentrup, H. Josef Vormoor, Lotte E. van der Wagen, Monique C. Minnema, Jan L. C. Loeffen, Henrike E. Karim-Kos

https://doi.org/10.3324/haematol.2023.283379

Editorials
Article

Profiling the activity of the para-caspase MALT1 in B-cell acute lymphoblastic leukemia for potential targeted therapeutic application (351 Online Views)

Firas M. Safa, Terri Rasmussen, Lorena Fontan, Min Xia, Ari Melnick, Adrian Wiestner, Patricia Lobelle-Rich, Jan A. Burger, Yara Mouawad, Hana Safah, Erik K Flemington, Nakhle S. Saba

https://doi.org/10.3324/haematol.2023.283178

Editorials
Article

Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for NK-cell therapy in acute myeloid leukemia (572 Online Views)

Yuta Kaito, Emi Sugimoto, Fumi Nakamura, Yutaka Tsukune, Makoto Sasaki, Shunsuke Yui, Hiroki Yamaguchi, Susumu Goyama, Yasuhito Nannya, Kinuko Mitani, Hideto Tamura, Yoichi Imai

https://doi.org/10.3324/haematol.2023.282915

Articles

ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms (324 Online Views)

Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Guo Ge, Lyndsey Bolanos, Mark Wunderlich, Johann-Christoph Jann, Alina Wein, Eva Altrock, Marie Demmerle, Sanjay Mukherjee, Abdullah Mahmood Ali, Felicitas Rapp, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Melda Göl, Ahmed Jawhar, Ali Darwich, Patrick Wuchter, Christel Weiss, Azra Raza, Jason M. Foulks, Daniel T Starczynowski, Feng-Chun Yang, Georgia Metzgeroth, Laurenz Steiner, Mohamad Jawhar, Wolf-Karsten Hofmann, Daniel Nowak

https://doi.org/10.3324/haematol.2023.282921

SH2 domain-containing inositol 5-phosphatases support the survival of Burkitt lymphoma cells by promoting energy metabolism (264 Online Views)

Florian Mayr, Vanessa Kruse, Dominik C. Fuhrmann, Sebastian Wolf, Jens Löber, Saed Alsouri, Nadia Paglilla, Kwang Lee, Björn Chapuy, Bernhard Brüne, Thorsten Zenz, Björn Häupl, Thomas Oellerich, Michael Engelke

https://doi.org/10.3324/haematol.2023.283663

Letters to the Editor

Catheter-related thrombosis in stem cell recipients: comparison of different types of catheter (185 Online Views)

Slawomir Milczarek, Piotr Kulig, Oliwia Piotrowska, Alina Zuchmanska, Anna Bielikowicz, Bogusław Machalinski

https://doi.org/10.3324/haematol.2023.283924

Spotlight Review

Oct 26, 2023

Review Articles

How we manage a high D-dimer (523 Online Views)

Massimo Franchini, Daniele Focosi, Mario Piergiulio Pezzo, Pier Mannuccio Mannucci

https://doi.org/10.3324/haematol.2023.283966

Articles

Impact of race and ethnicity on early mortality in multiple myeloma: a SEER analysis (276 Online Views)

John X. Wei, Aditi Shastri, R. Alejandro Sica, Ioannis Mantzaris, Noah Kornblum, Urvi Shah, Murali Janakiram, Kira Gritsman, Amit Verma, Mendel Goldfinger, Dennis Cooper, Nishi Shah

https://doi.org/10.3324/haematol.2023.283304

A Japanese retrospective study of non-tuberculous mycobacterial infection in children, adolescents, and young adult patients with hematologic-oncologic diseases (266 Online Views)

Yusuke Tsumura, Hideki Muramatsu, Nobuyuki Tetsuka, Takahiro Imaizumi, Kikue Sato, Kento Inoue, Yoshitomo Motomura, Yuko Cho, Daiki Yamashita, Daichi Sajiki, Ryo Maemura, Ayako Yamamori, Masayuki Imaya, Manabu Wakamatsu, Kotaro Narita, Shinsuke Kataoka, Motoharu Hamada, Rieko Taniguchi, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Yoshihiko Hoshino, Yoshiyuki Takahashi

https://doi.org/10.3324/haematol.2023.283636

Overall survival and causes of death in elderly patients with Hodgkin lymphoma: a Norwegian population-based case-control study (208 Online Views)

Kjersti Lia, Rasmus R.K. Jørgensen, Bente L.Wold, Øystein Fluge, Unn-Merete Fagerli, Hanne Bersvendsen, Idun B. Bø, Sameer Bhargava, Alexander Fosså

https://doi.org/10.3324/haematol.2023.283721

Letters to the Editor

Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients (315 Online Views)

Mayumi Hangai, Takahisa Kawaguchi, Masatoshi Takagi, Keitaro Matsuo, Soyoung Jeon, Charleston W.K. Chiang, Andrew T. Dewan, Adam J. de Smith, Toshihiko Imamura, Yasuhiro Okamoto, Akiko M. Saito, Takao Deguchi, Michiaki Kubo, Yoichi Tanaka, Yoko Ayukawa, Toshinari Hori, Kentaro Ohki, Nobutaka Kiyokawa, Takeshi Inukai, Yuki Arakawa, Makiko Mori, Daisuke Hasegawa, Daisuke Tomizawa, Hiroko Fukushima, Yuki Yuza, Yasushi Noguchi, Yuichi Taneyama, Setsuo Ota, Hiroaki Goto, Masakatsu Yanagimachi, Dai Keino, Kazutoshi Koike, Daisuke Toyama, Yozo Nakazawa, Kozue Nakamura, Koichi Moriwaki, Yujin Sekinaka, Daisuke Morita, Shinsuke Hirabayashi, Yosuke Hosoya, Yuri Yoshimoto, Hiroki Yoshihara, Miwa Ozawa, Shinobu Kobayashi, Naho Morisaki, Tshewang Gyeltshen, Osamu Takahashi, Yukinori Okada, Makiko Matsuda, Toshihiro Tanaka, Johji Inazawa, Junko Takita, Yasushi Ishida, Akira Ohara, Catherine Metayer, Joseph L. Wiemels, Xiaomei Ma, Shuki Mizutani, Katsuyoshi Koh, Yukihide Momozawa, Keizo Horibe, Fumihiko Matsuda, Motohiro Kato, Atsushi Manabe, Kevin Y. Urayama

https://doi.org/10.3324/haematol.2023.282914

BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics (251 Online Views)

Rongqing Aaron Pan, Youzhen Wang, Shumei Qiu, Mariana Villalobos-Ortiz, Jeremy Ryan, Erick Morris, Ensar Halilovic, Anthony Letai

https://doi.org/10.3324/haematol.2023.283060

Low-dose azacitidine, pioglitazone and all-trans retinoic acid is safe in patients aged ≥ 60 years with acute myeloid leukemia refractory to standard induction chemotherapy (AMLSG 26-16/AML-ViVA): results of the safety run-in phase (305 Online Views)

Daniel Heudobler, Florian Luke, Joachim Hahn, Matthias Grube, Pavla Schlosser, Stephan Kremers, Thomas Sudhoff, Jorg Westermann, Marie Luise Hutter-Kronke, Richard F. Schlenk, Daniela Weber, Peter Paschka, Florian Zeman, Hartmut Dohner, Wolfgang Herr, Albrecht Reichle, Simone Thomas

https://doi.org/10.3324/haematol.2023.283864

Case Reports

Cerebral venous sinus thrombosis and thrombocytopenia due to heparin-independent anti-PF4 antibodies after adenovirus infection (343 Online Views)

Günalp Uzun, Jan Zlamal, Karina Althaus, Andrea Bevot, Florian Hennersdorf, Nina Wolska, Anna Jock, Jan Kern, Vanya Icheva, Sven Poli, Ulrike Ernemann, Andreas Neu, Tamam Bakchoul

https://doi.org/10.3324/haematol.2023.284127

Oct 19, 2023

Editorials
Article

MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53 – a Nordic Lymphoma Group study (606 Online Views)

Joana M. Rodrigues, Peter Hollander, Lina Schmidt, Eirinaios Gkika, Masoud Razmara, Darshan Kumar, Christian Geisler, Kirsten Grønbæk, Christian W. Eskelund, Riikka Räty, Arne Kolstad, Christer Sundström, Ingrid Glimelius, Anna Porwit, Mats Jerkeman, Sara Ek

https://doi.org/10.3324/haematol.2023.283352

Articles

Outcomes of limited stage primary bone diffuse large B-cell lymphoma in the rituximab era: a multicenter, retrospective study (287 Online Views)

Alexandra Rezazadeh, Aniko Szabo, Arushi Khurana, David J. Inwards, Matthew A. Lunning, Nancy L. Bartlett, Paolo F. Caimi, Thomas D. Rodgers, Paul M. Barr, Sayan Mullick Chowdhury, Narendranath Epperla, Hiruni Mendries, Brian T. Hill, Timothy S. Oh, Reem Karmali, Julie E. Chang, Gaurav Goyal, Benjamin M. Parsons, Krista M. Isaac, Craig A. Portell, Kathleen Monahan, Malika Siker, David M. King, Timothy S. Fenske

https://doi.org/10.3324/haematol.2023.283210

Factors associated with refractoriness or early progression after idecabtagene vicleucel in patients with relapsed/refractory multiple myeloma: U.S. Myeloma Immunotherapy Consortium real world experience (576 Online Views)

Hamza Hashmi, Doris K. Hansen, Lauren C. Peres, Omar Castaneda Puglianini, Ciara Freeman, Gabriel De Avila, Surbhi Sidana, Leyla Shune, Douglas W. Sborov, James Davis, Charlotte Wagner, Mehmet H. Kocoglu, Shebli Atrash, Peter Voorhees, Gary Simmons, Christopher Ferreri, Nilesh Kalariya, Larry D. Anderson Jr., Aimaz Afrough, Danai Dima, Jack Khouri, Joseph McGuirk, Fred Locke, Rachid Baz, Krina K. Patel, Melissa Alsina

https://doi.org/10.3324/haematol.2023.283888

Differential transcriptional control of hematopoiesis in congenital and cyclic neutropenia patients harboring ELANE mutations (230 Online Views)

Alexander Zeidler, Natalia Borbaran-Bravo, Benjamin Dannenmann, Malte Ritter, Masoud Nasri, Maksim Klimiankou, Sergey Kandabarau, Azadeh Zahabi, Josef König, Cornelia Zeidler, Julia Skokowa, Karl Welte

https://doi.org/10.3324/haematol.2023.284033

Impact of mild thrombocytopenia on bleeding and recurrent thrombosis in cancer (193 Online Views)

Rushad Patell, Charles Hsu, Minggao Shi, Michael A. Grosso, Anil Duggal, Harry R. Buller, Gary Raskob, Jeffrey I. Zwicker

https://doi.org/10.3324/haematol.2023.284192

Letters to the Editor

A study of 28 pregnant women with sickle cell disease and COVID-19: elevated maternal and fetal morbidity rates (151 Online Views)

Laure Joseph, Gonzalo De Luna, Emmanuelle Bernit, Pierre Cougoul, Aline Santin, Benoit Faucher, Anoosha Habibi, Alain Garou, Gylna Loko, Sarah Mattioni, Sandra Manceau, Jean Benoit Arlet, François Lionnet

https://doi.org/10.3324/haematol.2023.283300

Subcutaneous injection of IHP-102 prevents lung vaso-occlusion in sickle cell disease mice (297 Online Views)

Rikesh K. Dubey, Ravi Vats, Tomasz Brzoska, Tomasz W. Kaminski, Omika Katoch, Jesus Tejero, Gabriel Njikang, John Paderi, Prithu Sundd

https://doi.org/10.3324/haematol.2023.283716

Small myeloid subclones are present at diagnosis of multiple myeloma in patients who develop secondary myelodysplastic syndromes (226 Online Views)

Guillaume Escure, Elise Fournier, Cynthia Saade, Lama Hasan Bou Issa, Inès Arib, Rémi Tilmont, Nicolas Gazeau, Binta M. Thiam, Morgane Chovet, Maxime Delforge, Nicolas Gower, Léa Fléchon, Doriane Cavalieri, Paul Chauvet, Morgane Nudel, Laure Goursaud, Céline Berthon, Bruno Quesnel, Thierry Facon, Claude Preudhomme, Nicolas Duployez, Salomon Manier

https://doi.org/10.3324/haematol.2023.284050

Spotlight Review

Oct 12, 2023

Editorials
Letter to the Editor

Clinical outcomes of patients with myelofibrosis after immediate transition to momelotinib from ruxolitinib (1605 Online Views)

Ruben Mesa, Srdan Verstovsek, Uwe Platzbecker, Vikas Gupta, David Lavie, Pilar Giraldo, Christian Recher, Jean-Jacques Kiladjian, Stephen T. Oh, Aaron T. Gerds, Timothy Devos, Francesco Passamonti, Alessandro M. Vannucchi, Miklos Egyed, Ewa Lech-Maranda, Andrzej Pluta, Lars Nilsson, Kazuya Shimoda, Donal McLornan, Jun Kawashima, Barbara Klencke, Mei Huang, Bryan Strouse, Claire Harrison

https://doi.org/10.3324/haematol.2023.283106

Editorials
Article

Use, variability, and justification of eligibility criteria for phase II and III clinical trials in acute leukemia (487 Online Views)

Andrew Hantel, Marlise R. Luskin, Irum Khan, Elizabeth Warner, Anand A. Patel, Thomas P. Walsh, Daniel J. DeAngelo, Christopher S. Lathan, Gregory A. Abel

https://doi.org/10.3324/haematol.2023.283723

Editorials
Article

Prognostic value of European Leukemia Net 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia (481 Online Views)

Silvia Park, Tong Yoon Kim, Byung-Sik Cho, Daehun Kwag, Jong-Mi Lee, MyungShin Kim, Yonggoo Kim, Jamin Koo, Anjali Raman, Tae Kon Kim, Hee-Je Kim

https://doi.org/10.3324/haematol.2023.283606

Editorials
Letter to the Editor

Amphiregulin as monitoring biomarker for life-threatening acute graft-versus-host disease: secondary analysis of two prospective clinical trials (213 Online Views)

Shernan G. Holtan, Najla El Jurdi, Armin Rashidi, Brian C. Betts, Connor Demorest, John P Galvin, Margaret L. MacMillan, Daniel J. Weisdorf, Angela Panoskaltsis-Mortari, Michael A. Pratta

https://doi.org/10.3324/haematol.2023.283215

Articles

Targeting TFH cells is a novel approach for donor-specific antibody desensitization of allograft candidates: an in vitro and in vivo study (291 Online Views)

Ning Ma, Wei-Bing Wu, Xiang-Yu Zhao, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Xiao-Dong Mo, Yuan-Yuan Zhang, Xiao-Su Zhao, Yu-Qian Sun, Yi-Fei Cheng, Kai-Yan Liu, Ying-Jun Chang, Xiao-Jun Huang

https://doi.org/10.3324/haematol.2023.283698

Oct 5, 2023

Editorials
Article

DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response (555 Online Views)

Minjing Li, Xingli Wu, Meiyang Chen, Shiyu Hao, Yue Yu, Xiang Li, Erdi Zhao, Ming Xu, Zhenhai Yu, Zhiqiang Wang, Ning Xu, Changzhu Jin, Yancun Yin

https://doi.org/10.3324/haematol.2023.282691

Editorials
Article

Loncastuximab tesirine in relapsed/refractory diffuse large B-cell lymphoma: long-term efficacy and safety from the phase 2 LOTIS-2 study (1212 Online Views)

Paolo F. Caimi, Weiyun Z. Ai, Juan Pablo Alderuccio, Kirit M. Ardeshna, Mehdi Hamadani, Brian Hess, Brad S. Kahl, John Radford, Melhem Solh, Anastasios Stathis, Pier Luigi Zinzani, Ying Wang, Yajuan Qin, Luqiang Wang, Zhiying Cindy Xu, Carmelo Carlo-Stella

https://doi.org/10.3324/haematol.2023.283459

Articles

Outcome of combined modality treatment in first-line for stage I(E) peripheral T-cell lymphoma; a nationwide population-based cohort study from the Netherlands (453 Online Views)

Frederik O. Meeuwes, Mirian Brink, Wouter Plattel, Marjolein W.M. van der Poel, Marie José Kersten, Mariëlle Wondergem, Lara Böhmer, F.J. Sherida H. Woei-A-Jin, Otto Visser, Rimke Oostvogels, Patty M. Jansen, Karen J. Neelis, Anne P.G. Crijns, Laurien A. Daniëls, Tjeerd J.F. Snijders, Joost S.P. Vermaat, Gerwin A. Huls, Marcel Nijland

https://doi.org/10.3324/haematol.2023.283174

Susceptibility of pediatric acute lymphoblastic leukemia to STAT3 inhibition depends on p53 induction (389 Online Views)

Luca Gasparoli, Clemence Virely, Alexia Tsakaneli, Noelia Che, Darren Edwards, Jack Bartram, Michael Hubank, Deepali Pal, Olaf Heidenreich, Joost H.A. Martens, Jasper de Boer, Owen Williams

https://doi.org/10.3324/haematol.2023.283613

Letters to the Editor

Tucidinostat restores CCR4 expression in adult T-cell leukemia/lymphoma (400 Online Views)

Takahito Kawata, Takuya Shimizu, Takero Shindo, Kensuke Fujiwara, Suguru Morimoto, Mitsumasa Watanabe

https://doi.org/10.3324/haematol.2023.283266

Brentuximab vedotin with chemotherapy in adolescents and young adults with stage III or IV classical Hodgkin lymphoma in ECHELON-1 (795 Online Views)

Howland E. Crosswell, Ann S. LaCasce, Nancy L. Bartlett, David J. Straus, Kerry J. Savage, Pier Luigi Zinzani, Graham P. Collins, Michelle Fanale, Keenan Fenton, Cassie Dong, Harry Miao, Andrew P. Grigg

https://doi.org/10.3324/haematol.2023.283303

Venetoclax salvage therapy in relapsed/refractory multiple myeloma (553 Online Views)

Maximilian J. Steinhardt, Marietta Truger, Max Bittrich, Xiang Zhou, Julia Noderer, Christine Riedhammer, Xianghui Xiao, Sophia Gawlas, Philipp Weis, Florian Eisele, Claudia Haferlach, Julia Mersi, Johannes Waldschmidt, Hermann Einsele, Leo Rasche, K. Martin Kortüm

https://doi.org/10.3324/haematol.2023.283472

A patient with minimal myeloma treatment who survived for 20 years (408 Online Views)

Alenka Djarmila Behsen, Esten Nymoen Vandsemb, Tobias Schmidt Slørdahl, Henrik Hjorth-Hansen, Petter Quist-Paulsen, Kristine Misund, Anne-Marit Sponaas, Anders Waage

https://doi.org/10.3324/haematol.2023.283563

BH3 mimetics in relapsed and refractory adult acute lymphoblastic leukemia: a Campus ALL real-life study (244 Online Views)

Francesco Malfona, Ilaria Tanasi, Matteo Piccini, Cristina Papayannidis, Vincenzo Federico, Valentina Mancini, Elisa Roncoroni, Elisabetta Todisco, Simona Bianchi, Giulia Ciotti, Patrizia Chiusolo, Massimo Gentile, Valentina Gianfelici, Fabio Giglio, Michele Malagola, Antonino Mulé, Francesco Saraceni, Calogero Vetro, Francesco Zallio, Luca Vincenzo Cappelli, Giovanni Pizzolo, Robin Foà, Massimiliano Bonifacio, Sabina Chiaretti

https://doi.org/10.3324/haematol.2023.283684

Sep 28, 2023

Articles

Ribosomal protein S3 mediates drug resistance of proteasome inhibitor: potential therapeutic application in multiple myeloma (379 Online Views)

Gege Chen, Xuejie Gao, Xinyan Jia, Yingcong Wang, Li Xu, Dandan Yu, Shuaikang Chang, Hui Deng, Ke Hu, Guanli Wang, Bo Li, Zhijian Xu, Yumeng Lu, Huaping Wang, Ting Zhang, Dongliang Song, Guang Yang, Xiaosong Wu, Huabin Zhu, Weiliang Zhu, Jumei Shi

https://doi.org/10.3324/haematol.2023.282789

Profiling the activity of the para-caspase MALT1 in B-cell acute lymphoblastic leukemia for potential targeted therapeutic application (351 Online Views)

Firas M. Safa, Terri Rasmussen, Lorena Fontan, Min Xia, Ari Melnick, Adrian Wiestner, Patricia Lobelle-Rich, Jan A. Burger, Yara Mouawad, Hana Safah, Erik K Flemington, Nakhle S. Saba

https://doi.org/10.3324/haematol.2023.283178

Polatuzumab vedotin plus bendamustine and rituximab or obinutuzumab in relapsed/refractory follicular lymphoma: a phase Ib/II study (554 Online Views)

Christopher R. Flowers, Matthew J. Matasar, Alex F. Herrera, Mark Hertzberg, Sarit Assouline, Judit Demeter, Andrew McMillan, Amitkumar Mehta, Stephen Opat, Marek Trnňný, Lisa Musick, Jamie Hirata, Annie Yang, Laurie H. Sehn

https://doi.org/10.3324/haematol.2023.283557

Regulatory T cells hamper the efficacy of T-cell engaging bispecific antibody therapy (651 Online Views)

Mika Casey, Carol Lee, Wing Yu Kwok, Soi Cheng Law, Dillon Corvino, Maher K Gandhi, Simon J Harrison, Kyohei Nakamura

https://doi.org/10.3324/haematol.2023.283758

HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation (275 Online Views)

Carlotta Welters, Marthe-Lina Welters, Serena Stadler, Lars Bullinger, Julian Strobel, Holger Hackstein, Arunraj Dhamodaran, Thomas Blankenstein, Leo Hansmann

https://doi.org/10.3324/haematol.2023.283812

Letters to the Editor

Engineering a humanized animal model of polycythemia vera with minimal JAK2V617F mutant allelic burden (546 Online Views)

Tyler M. Parsons, Aishwarya Krishnan, Wangisa M.B. Dunuwille, Andrew L. Young, Jason Arand, Wentao Han, Grant A. Challen

https://doi.org/10.3324/haematol.2023.283858

Case Reports

Concurrent peripheral T-cell lymphoma and T-cell lymphoblastic leukemia/lymphoma with identical STIL::TAL1 fusion events (216 Online Views)

Mahsa Khanlari, Wei Wang, Yen-Chun Liu, Lu Wang, Jeffrey E. Rubnitz, Stephanie Dixon, Brent A. Orr, Obianuju M. Anelo, Zhongshan Cheng, Vidya Balagopal, Jeffery M. Klco

https://doi.org/10.3324/haematol.2023.283585

Sep 21, 2023

Editorials
Article

Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia (633 Online Views)

Edwin Quinten, Julieta H. Sepúlveda-Yáñez, Marvyn T. Koning, Janneke A. Eken, Dietmar Pfeifer, Valeri Nteleah, Ruben A.L. de Groen, Diego Alvarez Saravia, Jeroen Knijnenburg, Hedwig E. Stuivenberg-Bleijswijk, Milena Pantic, Andreas Agathangelidis, Andrea Keppler-Hafkemeyer, Cornelis A. M. van Bergen, Roberto Uribe-Paredes, Kostas Stamatopoulos, Joost S.P. Vermaat, Katja Zirlik, Marcelo A. Navarrete, Hassan Jumaa, Hendrik Veelken

https://doi.org/10.3324/haematol.2022.282542

Articles

Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for NK-cell therapy in acute myeloid leukemia (572 Online Views)

Yuta Kaito, Emi Sugimoto, Fumi Nakamura, Yutaka Tsukune, Makoto Sasaki, Shunsuke Yui, Hiroki Yamaguchi, Susumu Goyama, Yasuhito Nannya, Kinuko Mitani, Hideto Tamura, Yoichi Imai

https://doi.org/10.3324/haematol.2023.282915

Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders (820 Online Views)

Eily Cournoyer, Justin Ferrell, Susan Sharp, Anish Ray, Michael Jordan, Christopher Dandoy, Michael Grimley, Somak Roy, Robert Lorsbach, Arnold C. Merrow, Adam Nelson, Allison Bartlett, Jennifer Picarsic, Ashish Kumar

https://doi.org/10.3324/haematol.2023.283295

Idecabtagene vicleucel chimeric antigen receptor T-cell therapy for relapsed/refractory multiple myeloma with renal impairment (1082 Online Views)

Surbhi Sidana, Lauren C. Peres, Hamza Hashmi, Hitomi Hosoya, Christopher Ferreri, Jack Khouri, Danai Dima, Shebli Atrash, Peter Voorhees, Gary Simmons, Douglas W. Sborov, Nilesh Kalariya, Vanna Hovanky, Sushma Bharadwaj, David Miklos, Charlotte Wagner, Mehmet H. Kocoglu, Gurbakhash Kaur, James A. Davis, Shonali Midha, Murali Janakiram, Ciara Freeman, Melissa Alsina, Frederick Locke, Rebecca Gonzalez, Yi Lin, Joseph McGuirk, Aimaz Afrough, Leyla Shune, Krina K. Patel, Doris K. Hansen

https://doi.org/10.3324/haematol.2023.283940

Letters to the Editor

Bone mineral density in adult patients with pyruvate kinase deficiency on long-term mitapivat treatment (369 Online Views)

Hanny Al-Samkari, Rachael F. Grace, Andreas Glenthøj, Oliver Andres, Wilma Barcellini, Frédéric Galacteros, Kevin H. M. Kuo, D. Mark Layton, Marta Morado, Vip Viprakasit, Feng Tai, Rolandas Urbstonaitis, Jaime Morales, Bryan McGee, Eduard J. van Beers

https://doi.org/10.3324/haematol.2023.282884

Outcome heterogeneity of TP53-mutated myeloid neoplasms and the role of allogeneic hematopoietic cell transplantation (280 Online Views)

Sergiu Pasca, Saurav D. Haldar, Alexander Ambinder, Jonathan A. Webster, Tania Jain, W. Brian Dalton, Gabrielle T. Prince, Gabriel Ghiaur, Amy E. DeZern, Ivana Gojo, B. Douglas Smith, Theodoros Karantanos, Cory Schulz, Kristin Stokvis, Mark J. Levis, Richard J. Jones, Lukasz P. Gondek

https://doi.org/10.3324/haematol.2023.283886

Sep 14, 2023

Review Articles

Articles

Treg-targeted IL-2/anti-IL-2 complex controls graft-versus-host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation (451 Online Views)

Allan Thiolat, Caroline Pilon, Pamela Caudana, Audrey Moatti, Nhu Hanh To, Christine Sedlik, Mathieu Leclerc, Sébastien Maury, Eliane Piaggio, José L. Cohen

https://doi.org/10.3324/haematol.2022.282653

Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies (625 Online Views)

David W. Woolston, Nathan D. Lee, Mazyar Shadman, Elena Latorre-Esteves, Xin Ray Tee, Jeanne Fredrickson, Brendan F. Kohrn, Chaitra Ujjani, Ashley Eckel, Brian Till, Min Fang, Jerald Radich, Ivana Bozic, Rosa Ana Risques, Cecilia C.S. Yeung

https://doi.org/10.3324/haematol.2023.283372

Prognostic value of European Leukemia Net 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia (481 Online Views)

Silvia Park, Tong Yoon Kim, Byung-Sik Cho, Daehun Kwag, Jong-Mi Lee, MyungShin Kim, Yonggoo Kim, Jamin Koo, Anjali Raman, Tae Kon Kim, Hee-Je Kim

https://doi.org/10.3324/haematol.2023.283606

Letters to the Editor

A phase II study of interrupted and continuous dose lenalidomide in relapsed/refractory Hodgkin lymphoma (791 Online Views)

Todd A. Fehniger, Marcus P. Watkins, Nkiruka Ezenwajiaku, Fei Wan, David D. Hurd, Amanda F. Cashen, Kristie A. Blum, Andre Goy, Timothy S. Fenske, Nina D. Wagner-Johnston, Kenneth Carson, Marilyn J. Siegel, David Russler-Germain, Stephanie E. Schneider, Neha Mehta-Shah, Brad Kahl, Nancy L. Bartlett

https://doi.org/10.3324/haematol.2022.282246

Amphiregulin as monitoring biomarker for life-threatening acute graft-versus-host disease: secondary analysis of two prospective clinical trials (213 Online Views)

Shernan G. Holtan, Najla El Jurdi, Armin Rashidi, Brian C. Betts, Connor Demorest, John P Galvin, Margaret L. MacMillan, Daniel J. Weisdorf, Angela Panoskaltsis-Mortari, Michael A. Pratta

https://doi.org/10.3324/haematol.2023.283215

Oligosecretory Waldenström macroglobulinemia exhibits excellent treatment response and outcomes (929 Online Views)

Wenjie Xiong, Ying Yu, Chunyan Sun, Juan Du, Zhen Cai, Zanzan Wang, Xinxin Cao, Yuting Yan, Jiawen Chen, Yanshan Huang, Zhongxing Jiang, Huihan Wang, Ting Niu, Guangzhong Yang, Hua Xue, Bingzong Li, Honghui Huang, Zhenling Li, Qinhua Liu, Fei Li, Ou Bai, Min Mao, Rong Fu, Ling Wang, Chunrui Li, Xiaoxia Chu, Lihong Liu, Yujun Dong, Luqun Wang, Jun Luo, Yongqiang Wei, Rui Cui, Lugui Qiu, Jian Li, Shuhua Yi

https://doi.org/10.3324/haematol.2023.283402

Somatic variant profiling in chronic phase pediatric chronic myeloid leukemia (285 Online Views)

Yvonne Lisa Behrens, Laura Gaschler, Ronny Nienhold, Thea Reinkens, Elke Schirmer, Sabine Knöß, Renate Strasser, Stephanie Sembill, Zofia Wotschofsky, Meinolf Suttorp, Manuela Krumbholz, Brigitte Schlegelberger, Markus Metzler, Gudrun Göhring, Axel Karow

https://doi.org/10.3324/haematol.2023.283800

Case Reports

Sep 7, 2023

Editorials
Article

Genomic breakpoint specific monitoring of measurable residual disease in pediatric non-standard risk acute myeloid leukemia (457 Online Views)

Margarita Maurer-Granofszky, Stefan Kohrer, Susanna Fischer, Angela Schumich, Karin Nebral, Patrizia Larghero, Claus Meyer, Astrid Mecklenbrauker, Nora Muhlegger, Rolf Marschalek, Oskar A. Haas, Renate Panzer-Grumayer, Michael N. Dworzak

https://doi.org/10.3324/haematol.2022.282424

Editorials
Letter to the Editor

Phase II trials of zilucoplan in paroxysmal nocturnal hemoglobinuria (589 Online Views)

Austin G. Kulasekararaj, Anna-Elina Lehtinen, Cecily Forsyth, Shreyans Gandhi, Morag Griffin, Sixten Körper, Gabor Mikala, Petra Muus, Ulrik Overgaard, Christopher J. Patriquin, Humphrey Pullon, Yu-Min Shen, Ruth Spearing, Jeff Szer, Guillemette de la Borderie, Petra W. Duda, Ramin Farzaneh-Far, Sharan Ragunathan, Camil E. Sayegh, Douangsone D. Vadysirisack, Hubert Schrezenmeier

https://doi.org/10.3324/haematol.2022.281780

Editorials
Article

Ruxolitinib-based regimen in children with primary hemophagocytic lymphohistiocytosis (483 Online Views)

Jian Ge, Qing Zhang, Honghao Ma, Dong Wang, Yunze Zhao, Ting Zhu, Wenqian Wang, Chenxin Zhou, Ang Wei, Hongyun Lian, Maoquan Qin, Jun Yang, Zhigang Li, Tianyou Wang, Rui Zhang

https://doi.org/10.3324/haematol.2023.283478

Articles

Dynamic actin/septin network in megakaryocytes co-ordinates proplatelet elaboration (588 Online Views)

Isabelle C. Becker, Adrian R. Wilkie, Bret A. Unger, Anthony R. Sciaudone, Farheen Fatima, I-Ting Tsai, Ke Xu, Kellie R. Machlus, Joseph E. Italiano

https://doi.org/10.3324/haematol.2023.283369

Letters to the Editor

Prognostic value of minimal disseminated disease assessed using digital PCR for 3′ALK assays in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (187 Online Views)

Reiji Fukano, Yuka Iijima-Yamashita, Hideto Iwafuchi, Atsuko Nakazawa, Akiko M. Saito, Tetsuya Takimoto, Masahiro Sekimizu, Yutaka Suehiro, Takahiro Yamasaki, Shunji Hasegawa, Tetsuya Mori, Keizo Horibe

https://doi.org/10.3324/haematol.2023.282812

Frequent, high density expression of surface CD38 as a potential therapeutic target in adult T-lineage acute lymphoblastic leukemia (250 Online Views)

Sebastian Koslowski, Rainer Glauben, Stefan Habringer, Thomas Burmeister, Ulrich Keller, Monika Brüggemann, Nicola Gökbuget, Stefan Schwartz

https://doi.org/10.3324/haematol.2023.283814

Case Reports

Immune-mediated facial nerve paralysis in a myeloma patient post B-cell maturation antigen-targeted chimeric antigen receptor T cells (340 Online Views)

Yamini K. Kathari, Haroon Ahmad, Michael E. Kallen, Rima Koka, Destiny Omili, Thierry Iraguha, Jean Clement, Lily Pham, Mazhar Khalid, Xiaoxuan Fan, Etse Gebru, Patricia Lesho, Esther Park, Nishanthini Dishanthan, Jillian M. Baker, Kenneth A. Dietze, Kim G. Hankey, Ashraf Badros, Jean A. Yared, Saurabh Dahiya, Nancy M. Hardy, Hakan Kocoglu, Tim Luetkens, Aaron P. Rapoport, Djordje Atanackovic

https://doi.org/10.3324/haematol.2023.283296

Aug 31, 2023

Articles

Which is the best treatment strategy before autologous peripheral blood stem cell transplantation in POEMS syndrome? (280 Online Views)

Francesco Autore, Stefania Bramanti, Federica Lessi, Idanna Innocenti, Eugenio Galli, Serena Rocchi, Rossella Ribolla, Daniele Derudas, Stefania Oliva, Paola Stefanoni, Magda Marcatti, Angelo Schenone, Giorgio La Nasa, Claudia Crippa, Elena Zamagni, Marcello Riva, Rita Mazza, Daniele Mannina, Simona Sica, Andrea Bacigalupo, Luca Laurenti

https://doi.org/10.3324/haematol.2023.283719

Diffuse large B-cell lymphoma involving osseous sites: utility of response assessment by PET/CT and good long-term outcomes (514 Online Views)

Paola Ghione, Salma Ahsanuddin, Efrat Luttwak, Sabela Bobillo Varela, Reiko Nakajima, Laure Michaud, Kanika Gupta, Anastasia Navitski, David Straus, M. Lia Palomba, Alison Moskowitz, Ariela Noy, Paul Hamlin, Matthew Matasar, Anita Kumar, Lorenzo Falchi, Joachim Yahalom, Steven Horwitz, Andrew Zelenetz, Anas Younes, Gilles Salles, Heiko Schöder, Erel Joffe

https://doi.org/10.3324/haematol.2022.282643

Immunochemotherapy plus lenalidomide for high-risk mantle cell lymphoma with measurable residual disease evaluation (410 Online Views)

Zachary D. Epstein-Peterson, Esther Drill, Umut Aypar, Connie Lee Batlevi, Philip Caron, Ahmet Dogan, Pamela Drullinsky, John Gerecitano, Paul A. Hamlin, Caleb Ho, Allison Jacob, Ashlee Joseph, Leana Laraque, Matthew J. Matasar, Alison J. Moskowitz, Craig H. Moskowitz, Chelsea Mullins, Colette Owens, Gilles Salles, Heiko Schöder, David J. Straus, Anas Younes, Andrew D. Zelenetz, Anita Kumar

https://doi.org/10.3324/haematol.2023.282898

Lisocabtagene maraleucel for second-line relapsed or refractory large B-cell lymphoma: patient-reported outcomes from the PILOT study (690 Online Views)

Leo I. Gordon, Fei Fei Liu, Julia Braverman, Daanish Hoda, Nilanjan Ghosh, Mehdi Hamadani, Gerhard C. Hildebrandt, Lily Peng, Shien Guo, Ling Shi, Alison Sehgal

https://doi.org/10.3324/haematol.2023.283162

Loncastuximab tesirine in relapsed/refractory diffuse large B-cell lymphoma: long-term efficacy and safety from the phase 2 LOTIS-2 study (1212 Online Views)

Paolo F. Caimi, Weiyun Z. Ai, Juan Pablo Alderuccio, Kirit M. Ardeshna, Mehdi Hamadani, Brian Hess, Brad S. Kahl, John Radford, Melhem Solh, Anastasios Stathis, Pier Luigi Zinzani, Ying Wang, Yajuan Qin, Luqiang Wang, Zhiying Cindy Xu, Carmelo Carlo-Stella

https://doi.org/10.3324/haematol.2023.283459

MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53 – a Nordic Lymphoma Group study (606 Online Views)

Joana M. Rodrigues, Peter Hollander, Lina Schmidt, Eirinaios Gkika, Masoud Razmara, Darshan Kumar, Christian Geisler, Kirsten Grønbæk, Christian W. Eskelund, Riikka Räty, Arne Kolstad, Christer Sundström, Ingrid Glimelius, Anna Porwit, Mats Jerkeman, Sara Ek

https://doi.org/10.3324/haematol.2023.283352

Allogeneic hematopoietic stem cell transplantation in patients aged 60-79 years in Germany (1998-2018): a registry study (402 Online Views)

Jan Frederic Weller, Claudia Lengerke, Jürgen Finke, Johannes Schetelig, Uwe Platzbecker, Hermann Einsele, Thomas Schroeder, Christoph Faul, Matthias Stelljes, Peter Dreger, Igor W. Blau, Gerald Wulf, Johanna Tischer, Christoph Scheid, Ahmet Elmaagacli, Helga Neidlinger, Sarah Flossdorf, Martin Bornhäuser, Wolfgang Bethge, Katharina Fleischhauer, Nicolaus Kröger, Liesbeth C. de Wreede, Maximilian Christopeit

https://doi.org/10.3324/haematol.2023.283175

Quantification of cyclin D1 and D2 proteins in multiple myeloma identifies different expression patterns from those revealed by gene expression profiling (340 Online Views)

Ignacio J. Cardona-Benavides, Irena Misiewicz-Krzeminska, Elizabeta A. Rojas, Cristina De Ramón, Antonio Sanz-Solas, Isabel Isidro, Dalia Quwaider, Aida M. López-Guerrero, Myriam Cuadrado, María-José Calasanz, Laura Rosiñol, Joaquín Martínez-López, Jesús F. San Miguel, María-Victoria Mateos, Luis A. Corchete, Norma C. Gutiérrez

https://doi.org/10.3324/haematol.2023.283445

Tafasitamab for patients with relapsed or refractory diffuse large B-cell lymphoma: final 5-year efficacy and safety in the phase II L-MIND study (1458 Online Views)

Johannes Duell, Pau Abrisqueta, Marc Andre, Gianluca Gaidano, Eva Gonzales-Barca, Wojciech Jurczak, Nagesh Kalakonda, Anna Marina Liberati, Kami J Maddocks, Tobias Menne, Zsolt Nagy, Olivier Tournilhac, Christian Kuffer, Abhishek Bakuli, Aasim Amin, Konstantin Gurbanov, Gilles Salles

https://doi.org/10.3324/haematol.2023.283480

ANCHOR: melflufen plus dexamethasone and daratumumab or bortezomib in relapsed/refractory multiple myeloma—final results of a phase I/IIa study (1026 Online Views)

Enrique M. Ocio, Yvonne A. Efebera, Roman Hájek, Jan Straub, Vladimir Maisnar, Jean-Richard Eveillard, Lionel Karlin, María-Victoria Mateos, Albert Oriol, Vincent Ribrag, Paul G. Richardson, Stefan Norin, Jakob Obermüller, Nicolaas A. Bakker, Luděk Pour

https://doi.org/10.3324/haematol.2023.283490

Efficacy and safety of melflufen plus daratumumab and dexamethasone in relapsed/refractory multiple myeloma: results from the randomized, open-label, phase III LIGHTHOUSE study (1731 Online Views)

Luděk Pour, Monika Szarejko, Jelena Bila, Fredrik H. Schjesvold, Ivan Spicka, Vladimir Maisnar, Artur Jurczyszyn, Zhanet Grudeva-Popova, Roman Hájek, Ganna Usenko, Marcus Thuresson, Stefan Norin, Sara Jarefors, Nicolaas A. Bakker, Paul G. Richardson, Maria-Victoria Mateos

https://doi.org/10.3324/haematol.2023.283509

The changing spectrum of infection with BCMA and GPRC5D targeting bispecific antibody (bsAb) therapy in patients with relapsed refractory multiple myeloma (1026 Online Views)

Lindsay Hammons, Aniko Szabo, Abhishek Janardan, Vineel Bhatlapenumarthi, Evanka Annyapu, Binod Dhakal, Samer Al Hadidi, Sabarinath Venniyil Radhakrishnan, Ravi Narra, Divaya Bhutani, Sharmilan Thanendrarajan, Siegfried Janz, Maurizio Zangari, Suzanne Lentzsch, Frits van Rhee, Juan Carlos Rico Crescencio, Anita D’Souza, Rajshekhar Chakraborty, Meera Mohan, Carolina Schinke

https://doi.org/10.3324/haematol.2023.283590

Prognostic relevance of clonal hematopoiesis in myeloid neoplastic transformation in patients with follicular lymphoma treated with radioimmunotherapy (328 Online Views)

Zhuoer Xie, Terra Lasho, Arushi Khurana, Alejandro Ferrer, Christy Finke, Abhishek A. Mangaonkar, Stephen Ansell, Jenna Fernandez, Mithun Vinod Shah, Aref Al-Kali, Naseema Gangat, Jithma Abeykoon, Thomas E. Witzig, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2023.283727

Letters to the Editor

Myeloid lineage switch in KMT2A-rearranged acute lymphoblastic leukemia treated with lymphoid lineage-directed therapies (413 Online Views)

Alex Bataller, Tareq Abuasab, David McCall, Wei Wang, Branko Cuglievan, Ghayas C. Issa, Elias Jabbour, Nicholas Short, Courtney D. DiNardo, Guilin Tang, Guillermo Garcia-Manero, Hagop M. Kantarjian, Koji Sasaki

https://doi.org/10.3324/haematol.2023.283705

Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia (321 Online Views)

Hanna M. Ingelman-Sundberg, Lisa Blixt, David Wullimann, Jinghua Wu, Yu Gao, Katie Healy, Sandra Muschiol, Gordana Bogdanovic, Mikael Åberg, Christian Kjellander, Alba Grifoni, Alessandro Sette, Soo Aleman, Puran Chen, Ola Blennow, Lotta Hansson, Hans-Gustaf Ljunggren, Margaret Sällberg Chen, Marcus Buggert, Anders Österborg

https://doi.org/10.3324/haematol.2023.282894

Quantitative evaluation of the clinical severity of hemoglobin H disease in a cohort of 591 patients using a scoring system based on regression analysis (303 Online Views)

Yumeng Liu, Yuan Zhuang, Jianhong Chen, Zeyan Zhong, Jianpei Fang, Xinyu Li, Bin Xiao, Pingping Li, Bin Lin, Zhenzhong Tao, Yidan Liang, Peng Lin, Xingmin Wang, Mengyang Song, Hualei Luo, Lang Qin, Li Huang, Jufang Tan, Hailiang Li, Tianyu Zhong, Lian Yu, Zhixiang Liu, Deguo Tang, Yongzhong Zhao, Xinhua Zhang, Yuhua Ye, Xiangmin Xu

https://doi.org/10.3324/haematol.2023.283211

Survival disparities between children and adolescents and young adults for the major subtypes of non-Hodgkin lymphoma in the Netherlands: a large population-based study (268 Online Views)

Maya Schulpen, Auke Beishuizen, Martine E. D. Chamuleau, Avinash G. Dinmohamed, Friederike A. G. Meyer-Wentrup, H. Josef Vormoor, Lotte E. van der Wagen, Monique C. Minnema, Jan L. C. Loeffen, Henrike E. Karim-Kos

https://doi.org/10.3324/haematol.2023.283379

Thiostrepton induces cell death of acute myeloid leukemia blasts and the associated macrophage population (256 Online Views)

Isabel Weinhäuser, Diego A. Pereira-Martins, Jacobien R. Hilberink, Annet Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Jan Jacob Schuringa

https://doi.org/10.3324/haematol.2023.283621

Aug 24, 2023

Editorials
Article

BCL3-rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases (599 Online Views)

Anna Carbo-Meix, Francesca Guijarro, Luojun Wang, Marta Grau, Romina Royo, Gerard Frigola, Heribert Playa-Albinyana, Marco M. Buhler, Guillem Clot, Marti Duran-Ferrer, Junyan Lu, Isabel Granada, Maria-Joao Baptista, Jose-Tomas Navarro, Blanca Espinet, Anna Puiggros, Gustavo Tapia, Laura Bandiera, Gabriella De Canal, Emanuela Bonoldi, Fina Climent, Inmaculada Ribera-Cortada, Mariana Fernandez-Caballero, Esmeralda de la Banda, Janilson do Nascimento, Alberto Pineda, Dolors Vela, Maria Rozman, Marta Aymerich, Charlotte Syrykh, Pierre Brousset, Miguel Perera, Lucrecia Yanez, Jesus Xavier Ortin, Esperanza Tuset, Thorsten Zenz, James R. Cook, Steven H. Swerdlow, Jose I. Martin-Subero, Dolors Colomer, Estella Matutes, Silvia Bea, Dolors Costa, Ferran Nadeu, Elias Campo

https://doi.org/10.3324/haematol.2023.283209

Editorials
Article

Lymphocyte migration and retention properties affected by ibrutinib in chronic lymphocytic leukemia (796 Online Views)

Javier Rey-Barroso, Alice Munaretto, Nelly Rouquié, Aurélie Mougel, Malika Chassan, Sébastien Gadat, Océane Dewingle, Renaud Poincloux, Sarah Cadot, Loïc Ysebaert, Anne Quillet-Mary, Loïc Dupré

https://doi.org/10.3324/haematol.2022.282466

Articles

SUMOylation inhibitor TAK-981 (subasumstat) synergizes with 5-azacitidine in preclinical models of acute myeloid leukemia (1025 Online Views)

Ludovic Gabellier, Marion De Toledo, Mehuli Chakraborty, Dana Akl, Rawan Hallal, Mays Aqrouq, Giovanni Buonocore, Clara Recasens-Zorzo, Guillaume Cartron, Abigaïl Delort, Marc Piechaczyk, Denis Tempé, Guillaume Bossis

https://doi.org/10.3324/haematol.2023.282704

Letters to the Editor

Identification of PSMB4 and PSMD4 as novel target genes correlated with 1q21 amplification in patients with smoldering myeloma and multiple myeloma (328 Online Views)

Jessica Burroughs Garcia, Paola Storti, Nicolas Thomas Iannozzi, Valentina Marchica, Luca Agnelli, Denise Toscani, Valentina Franceschi, Giannalisa Todaro, Gabriella Sammarelli, Laura Notarfranchi, Matteo Scita, Benedetta Dalla Palma, Vincenzo Raimondi, Oxana Lungu, Giancarlo Pruneri, Gaetano Donofrio, Nicola Giuliani

https://doi.org/10.3324/haematol.2023.283200

Aug 17, 2023

Editorials
Article

Current use of androgens in bone marrow failure disorders: a report from the Severe Aplastic Anemia Working Party of the European Society of Blood and Marrow Transplantation (1593 Online Views)

Simona Pagliuca, Austin G. Kulasekararaj, Dirk-Jan Eikema, Brian Piepenbroek, Raheel Iftikhar, Tariq Mahmood Satti, Morag Griffin, Marica Laurino, Alphan Kupesiz, Yves Bertrand, Bruno Fattizzo, Ibrahim Yakoub-Agha, Mahmoud Aljurf, Paola Corti, Erika Massaccesi, Bruno Lioure, Marisa Calabuig, Matthias Klammer, Emel Unal, Depei Wu, Patrice Chevallier, Edouard Forcade, John A. Snowden, Hakan Ozdogu, Antonio Risitano, Régis Peffault de Latour

https://doi.org/10.3324/haematol.2023.282935

Editorials
Article

Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation (716 Online Views)

Ahmed Waraky, Anders Östlund, Tina Nilsson, Dieter Weichenhan, Pavlo Lutsik, Marion Bähr, Joschka Hey, Gürcan Tunali, Jenni Adamsson, Susanna Jacobsson, Mohammad Hamdy Abdelrazak Morsy, Susann Li, Linda Fogelstrand, Christoph Plass, Lars Palmqvist

https://doi.org/10.3324/haematol.2022.282255

Editorials
Letter to the Editor

Exclusion of persistent mutations in splicing factor genes and isocitrate dehydrogenase 2 improves the prognostic power of molecular measurable residual disease assessment in acute myeloid leukemia (353 Online Views)

Tracy Murphy, Jinfeng Zou, Andrea Arruda, Ting Ting Wang, Zhen Zhao, Yangqiao Zheng, Vikas Gupta, Dawn Maze, Caroline McNamara, Mark D. Minden, Aaron Schimmer, Hassan Sibai, Karen Yee, Jose-Mario Capo-Chichi, Tracy Stockley, Andre Schuh, Scott V. Bratman, Steven M. Chan

https://doi.org/10.3324/haematol.2023.283510

Review Articles

Articles

Isatuximab plus carfilzomib and dexamethasone in patients with early versus late relapsed multiple myeloma: IKEMA subgroup analysis (1095 Online Views)

Thierry Facon, Philippe Moreau, Ross Baker, Chang-Ki Min, Xavier Leleu, Mohamad Mohty, Lionel Karlin, Nicole M. Armstrong, Christina Tekle, Sandrine Schwab, Marie-Laure Risse, Thomas Martin

https://doi.org/10.3324/haematol.2023.283073

Spontaneous remission and loss of monosomy 7: a window of opportunity for young children with SAMD9L syndrome (471 Online Views)

Miriam Erlacher, Felicia Andresen, Martina Sukova, Jan Stary, Barbara de Moerloose, Jutte van der Werff Ten Bosch, Michael Dworzak, Markus G. Seidel, Sophia Polychronopoulou, Rita Beier, Christian P. Kratz, Michaela Nathrath, Michael C. Frühwald, Gudrun Göhring, Anke K. Bergmann, Christina Mayerhofer, Dirk Lebrecht, Senthilkumar Ramamoorthy, Ayami Yoshimi, Brigitte Strahm, Marcin W. Wlodarski, Charlotte M. Niemeyer

https://doi.org/10.3324/haematol.2023.283591

Letters to the Editor

Red cell distribution width as a new prognostic biomarker in refractory chronic graft-versus-host disease (256 Online Views)

Eduard Schulz, Filip Pirsl, Noa G. Holtzman, David Beshensky, Edward W. Cowen, Sandra A. Mitchell, Seth M. Steinberg, Steven Z. Pavletic

https://doi.org/10.3324/haematol.2023.283646

Inflammation is predictive of outcome in Waldenström macroglobulinemia treated by Bruton tyrosine kinase inhibitors: a multicentric real-life study (491 Online Views)

Pierre-Edouard Debureaux, Nathalie Forgeard, Dikelele Elessa, Stéphanie Harel, Laurent Frenzel, Bruno Royer, Alexis Talbot, Sylvain Choquet, Frederic Davi, Florence Nguyen-Khac, Wendy Cuccuini, Morgane Cheminant, Clotilde Bravetti, Gregory Lazarian, Sophie Kaltenbach, Olivier Hermine, Damien Roos-Weil, Marion Espéli, Karl Balabanian, Bertrand Arnulf

https://doi.org/10.3324/haematol.2023.283141

SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria (563 Online Views)

Morag Griffin, Dirk-Jan Eikema, Inge Verheggen, Alexander Kulagin, Jennifer M-L. Tjon, Bruno Fattizzo, Wendy Ingram, Uzma Zaidi, Lana Desnica, Sabrina Giammarco, Joanna Drozd-Sokolowska, Blanca Xicoy, Andrea Patriarca, Michael Loschi, Anna Szmigielska-Kaplon, Fabian Beier, Alessandro Cignetti, Beatrice Drexler, Eleni Gavriilaki, Francesco Lanza, Corentin Orvain, Antonio Maria Risitano, Rafael de la Camara, Régis Peffault de Latour

https://doi.org/10.3324/haematol.2023.283863

Spotlight Review

Aug 10, 2023

Articles

BCL3-rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases (599 Online Views)

Anna Carbo-Meix, Francesca Guijarro, Luojun Wang, Marta Grau, Romina Royo, Gerard Frigola, Heribert Playa-Albinyana, Marco M. Buhler, Guillem Clot, Marti Duran-Ferrer, Junyan Lu, Isabel Granada, Maria-Joao Baptista, Jose-Tomas Navarro, Blanca Espinet, Anna Puiggros, Gustavo Tapia, Laura Bandiera, Gabriella De Canal, Emanuela Bonoldi, Fina Climent, Inmaculada Ribera-Cortada, Mariana Fernandez-Caballero, Esmeralda de la Banda, Janilson do Nascimento, Alberto Pineda, Dolors Vela, Maria Rozman, Marta Aymerich, Charlotte Syrykh, Pierre Brousset, Miguel Perera, Lucrecia Yanez, Jesus Xavier Ortin, Esperanza Tuset, Thorsten Zenz, James R. Cook, Steven H. Swerdlow, Jose I. Martin-Subero, Dolors Colomer, Estella Matutes, Silvia Bea, Dolors Costa, Ferran Nadeu, Elias Campo

https://doi.org/10.3324/haematol.2023.283209

Feasibility and outcomes after dose reduction of immunochemotherapy in young adults with Burkitt lymphoma and leukemia: results of the BURKIMAB14 trial (356 Online Views)

Josep-Maria Ribera, Mireia Morgades, Olga Garcia-Calduch, Maialen Sirvent, Buenaventura Buendia, Marta Cervera, Hugo Luzardo, Jesus-Maria Hernandez-Rivas, Marta Sitges, Irene Garcia-Cadenas, Pau Abrisqueta, Pau Montesinos, Mariana Bastos-Oreiro, Maria-Paz Queipo de Llano, Pilar Bravo, Anna Torrent, Pilar Herrera, Antoni Garcia-Guinon, Ferran Vall-llovera, Josefina Serrano, Maria-Jose Terol, Juan-Miguel Bergua, Ana Garcia-Noblejas, Cristina Barrenetxea, Laura Llorente, Daniel Garcia-Belmonte, Eva Gimeno, Antonia Cladera, Santiago Mercadal, Juan-Manuel Sancho

https://doi.org/10.3324/haematol.2023.283342

Use, variability, and justification of eligibility criteria for phase II and III clinical trials in acute leukemia (487 Online Views)

Andrew Hantel, Marlise R. Luskin, Irum Khan, Elizabeth Warner, Anand A. Patel, Thomas P. Walsh, Daniel J. DeAngelo, Christopher S. Lathan, Gregory A. Abel

https://doi.org/10.3324/haematol.2023.283723

Aug 3, 2023

Editorials
Letter to the Editor

An accessible patient-derived xenograft model of low-risk myelodysplastic syndromes (310 Online Views)

Patric Teodorescu, Sergiu Pasca, InYoung Choi, Cynthia Shams, W. Brian Dalton, Lukasz P. Gondek, Amy E. DeZern, Gabriel Ghiaur

https://doi.org/10.3324/haematol.2023.282967

Editorials
Article

Effect of age and treatment on predictive value of measurable residual disease: implications for clinical management of adult patients with acute myeloid leukemia (406 Online Views)

Francesco Mannelli, Matteo Piccini, Sara Bencini, Giacomo Gianfaldoni, Benedetta Peruzzi, Roberto Caporale, Barbara Scappini, Laura Fasano, Elisa Quinti, Gaia Ciolli, Andrea Pasquini, Francesca Crupi, Sofia Pilerci, Fabiana Pancani, Leonardo Signori, Danilo Tarantino, Chiara Maccari, Vivian Paradiso, Francesco Annunziato, Paola Guglielmelli, Alessandro M. Vannucchi

https://doi.org/10.3324/haematol.2023.283196

Editorials

Articles

Phenotypic profiling of CD34+ cells by advanced flow cytometry improves diagnosis of juvenile myelomonocytic leukemia (420 Online Views)

Cristina Bugarin, Laura Antolini, Chiara Buracchi, Sergio Matarraz, Tiziana Angela Coliva, Vincent H. van der Velden, Tomasz Szczepanski, Elaine Sobral da Costa, Alita van der Sluijs, Michaela Novakova, Ester Mejstrikova, Stefan Nierkens, Fabiana Vieira de Mello, Paula Fernandez, Carmen Aanei, Łukasz Sędek, Luisa Strocchio, Riccardo Masetti, Laura Sainati, Jan Philippé, Maria Grazia Valsecchi, Franco Locatelli, Jacques J.M. van Dongen, Andrea Biondi, Alberto Orfao, Giuseppe Gaipa

https://doi.org/10.3324/haematol.2023.282805

Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization (512 Online Views)

Marion Ciudad, Sethi Ouandji, Baptiste Lamarthée, Claudie Cladière, Thibault Ghesquière, Martin Nivet, Marine Thébault, Romain Boidot, Agnès Soudry-Faure, Sandy Chevrier, Corentin Richard, Thibault Maillet, François Maurier, Hélène Greigert, Coraline Genet, André Ramon, Malika Trad, Valérie Predan, Philippe Saas, Maxime Samson, Bernard Bonnotte, Sylvain Audia

https://doi.org/10.3324/haematol.2023.282859

Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax (459 Online Views)

Fen Zhu, Jennifer L. Crombie, Wei Ni, Nguyet-Minh Hoang, Swati Garg, Liam Hackett, Stephen J. F. Chong, Mary C. Collins, Lixin Rui, James Griffin, Matthew S. Davids

https://doi.org/10.3324/haematol.2023.283245

Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia (463 Online Views)

Laura W. Dillon, Jake Higgins, Hassan Nasif, Megan Othus, Lan Beppu, Thomas H. Smith, Elizabeth Schmidt, Charles C. Valentine III, Jesse J. Salk, Brent L Wood, Harry P. Erba, Jerald P. Radich, Christopher S. Hourigan

https://doi.org/10.3324/haematol.2023.283520

Minor clone of del(17p) provides a reservoir for relapse in multiple myeloma (1445 Online Views)

Jian Cui, Rui Lv, Tengteng Yu, Wenqiang Yan, Jingyu Xu, Huishou Fan, Lingna Li, Yuntong Liu, Chenxing Du, Shuhui Deng, Weiwei Sui, Yan Xu, Shuhua Yi, Dehui Zou, Lugui Qiu, Gang An

https://doi.org/10.3324/haematol.2023.283533

Letters to the Editor

Phase II trials of zilucoplan in paroxysmal nocturnal hemoglobinuria (589 Online Views)

Austin G. Kulasekararaj, Anna-Elina Lehtinen, Cecily Forsyth, Shreyans Gandhi, Morag Griffin, Sixten Körper, Gabor Mikala, Petra Muus, Ulrik Overgaard, Christopher J. Patriquin, Humphrey Pullon, Yu-Min Shen, Ruth Spearing, Jeff Szer, Guillemette de la Borderie, Petra W. Duda, Ramin Farzaneh-Far, Sharan Ragunathan, Camil E. Sayegh, Douangsone D. Vadysirisack, Hubert Schrezenmeier

https://doi.org/10.3324/haematol.2022.281780

Colchicine reduces inflammation in a humanized transgenic murine model of sickle cell disease (232 Online Views)

Raghda T. Fouda, Hemanth M. Cherukury, Stacy B. Kiven, Natalie R. Garcia, Donovan A. Argueta, Graham J. Velasco, Kalpna Gupta, John D. Roberts

https://doi.org/10.3324/haematol.2023.283377

Impaired T-cell response to mRNA vaccination heralds risk of COVID-19 in long-term allogeneic hematopoietic stem cell transplantation survivors (298 Online Views)

Sigrun Einarsdottir, Jesper Waldenström, Andreas Törnell, Johan Ringlander, Joakim B. Stenbäck, Sebastian Malmström, Kristoffer Hellstrand, Anna Martner, Martin Lagging

https://doi.org/10.3324/haematol.2023.283551

Molecular predictors of response and survival following IDH1/2 inhibitor monotherapy in acute myeloid leukemia (331 Online Views)

Naseema Gangat, Kristen McCullough, Maymona Abdelmagid, Omer Karrar, Marissa Powell, Aref Al-Kali, Hassan Alkhateeb, Kebede Begna, Abhishek Mangaonkar, Antoine Saliba, Mehrdad Hefazi Torghabeh, Mark Litzow, William Hogan, Mithun Shah, Mrinal Patnaik, Animesh Pardanani, Talha Badar, James Foran, Jeanne Palmer, Lisa Sproat, Cecilia Arana Yi, Ayalew Tefferi

https://doi.org/10.3324/haematol.2023.283732

Jul 27, 2023

Articles

DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response (555 Online Views)

Minjing Li, Xingli Wu, Meiyang Chen, Shiyu Hao, Yue Yu, Xiang Li, Erdi Zhao, Ming Xu, Zhenhai Yu, Zhiqiang Wang, Ning Xu, Changzhu Jin, Yancun Yin

https://doi.org/10.3324/haematol.2023.282691

TTK/MPS1 inhibitor OSU-13 targets the mitotic checkpoint and is a potential therapeutic strategy for myeloma (390 Online Views)

Larissa Valle Guilhen Longo, Tiffany Hughes, Betina McNeil-Laidley, Francesca Cottini, Gerard Hilinski, Elizabeth Merritt, Don M. Benson

https://doi.org/10.3324/haematol.2023.282838

IgH 3’RR recombination uncovers a non-germinal center imprint and c-MYC-dependent IgH rearrangement in unmutated chronic lymphocytic leukemia (409 Online Views)

Israa Al Jamal, Milene Parquet, Kenza Guiyedi, Said Aoufouchi, Morwenna Le Guillou, David Rizzo, Justine Pollet, Marine Dupont, Melanie Boulin, Nathalie Faumont, Hend Boutouil, Fabrice Jardin, Philippe Ruminy, Chahrazed El Hamel, Justine Lerat, Samar Al Hamaoui, Nehman Makdissy, Jean Feuillard, Nathalie Gachard, Sophie Peron

https://doi.org/10.3324/haematol.2023.282897

PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma (715 Online Views)

Patrick Nylund, Berta Garrido-Zabala, Alba Atienza Párraga, Louella Vasquez, Paul Theodor Pyl, George Mickhael Harinck, Anqi Ma, Jian Jin, Fredrik Öberg, Antonia Kalushkova, Helena Jernberg Wiklund

https://doi.org/10.3324/haematol.2023.282965

Jul 20, 2023

Editorials
Letter to the Editor

Editorials
Article

Impact of viral hepatitis therapy in multiple myeloma and other monoclonal gammopathies linked to hepatitis B or C viruses (543 Online Views)

Alba Rodríguez-García, Nicolas Mennesson, Gema Hernandez-Ibarburu, María Luz Morales, Laurent Garderet, Lorine Bouchereau, Sophie Allain-Maillet, Eric Piver, Irene Marbán, David Rubio, Edith Bigot-Corbel, Joaquín Martínez-López, María Linares, Sylvie Hermouet

https://doi.org/10.3324/haematol.2023.283096

Editorials
Article

Outcomes after intensive chemotherapy for secondary and myeloidrelated changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry (557 Online Views)

David Martínez-Cuadrón, Juan E. Megías-Vericat, Cristina Gil, Teresa Bernal, Mar Tormo, Pilar Martínez-Sánchez, Carlos Rodríguez-Medina, Josefina Serrano, Pilar Herrera, José A. Pérez Simón, María J. Sayas, Juan Bergua, Esperanza Lavilla-Rubira, Maria Luz Amigo, Celina Benavente, Jose L. López Lorenzo, Manuel M. Pérez-Encinas, María B. Vidriales, Mercedes Colorado, Beatriz de Rueda, Raimundo García-Boyero, Sandra Marini, Julio García-Suárez, María López-Pavía, Maria I. Gómez-Roncero, Víctor Noriega, Aurelio López, Jorge Labrador, Ana Cabello, Claudia Sossa, Lorenzo Algarra, Mariana Stevenazzi, Antonio Solana-Altabella, Blanca Boluda, Pau Montesinos

https://doi.org/10.3324/haematol.2022.282506

Editorials
Article

Adenosine signaling inhibits erythropoiesis and promotes myeloid differentiation (534 Online Views)

Mahmoud Mikdar, Marion Serra, Elia Colin, Romain Duval, Emilie-Fleur Gauthier, Yann Lamarre, Yves Colin, Caroline Le Van Kim, Thierry Peyrard, Bérengère Koehl, Slim Azouzi

https://doi.org/10.3324/haematol.2022.281823

Editorials
Article

Patient-reported treatment response in chronic graft-versus-host disease (520 Online Views)

Annie Im, Iskra Pusic, Lynn Onstad, Carrie L. Kitko, Betty K. Hamilton, Amin M. Alousi, Mary E. Flowers, Stefanie Sarantopoulos, Paul Carpenter, Jennifer White, Sally Arai, Najla El Jurdi, George Chen, Corey Cutler, Stephanie Lee, Joseph Pidala

https://doi.org/10.3324/haematol.2023.282734

Articles

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma (611 Online Views)

Yanmeng Wang, Catharina Muylaert, Arne Wyns, Philip Vlummens, Kim De Veirman, Karin Vanderkerken, Esther Zaal, Celia Berkers, Jérome Moreaux, Elke De Bruyne, Eline Menu

https://doi.org/10.3324/haematol.2023.282866

Fludarabine, cytarabine, and idarubicin with or without venetoclax in patients with relapsed/refractory acute myeloid leukemia (743 Online Views)

Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Adrian Schwarzer, Arnold Kloos, Christian Koenecke, Michael Stadler, Gudrun Gohring, Yvonne Lisa Behrens, Zhixiong Li, Louisa-Kristin Dallmann, Piroska Klement, Catherin Albert, Martin Wichmann, Yasmine Alwie, Axel Benner, Maral Saadati, Arnold Ganser, Felicitas Thol, Michael Heuser

https://doi.org/10.3324/haematol.2023.282912

Results from a phase I trial of pembrolizumab plus vorinostat in relapsed/refractory B-cell non-Hodgkin lymphoma (593 Online Views)

James Godfrey, Matthew Mei, Lu Chen, Joo Y. Song, Victoria Bedell, Elizabeth Budde, Saro Armenian, Sandrine Puverel, Liana Nikolaenko, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Steven T. Rosen, Stephen J. Forman, Leslie L. Popplewell, Larry W. Kwak, Alex F. Herrera

https://doi.org/10.3324/haematol.2023.283002

Changing trends in the risk factors for second primary malignancies after autologous stem cell transplantation for multiple myeloma before and after the introduction of proteasome inhibitors and immunomodulatory drugs (571 Online Views)

Hiroyuki Takamatsu, Tomohiro Matsuda, Shohei Mizuno, Tsutomu Takahashi, Shin-ichi Fuchida, Ichiro Hanamura, Keisuke Kataoka, Nobuhiro Tsukada, Morio Matsumoto, Akira Hangaishi, Noriko Doki, Naoyuki Uchida, Masashi Sawa, Yumiko Maruyama, Shingo Kurahashi, Koji Nagafuji, Yoriko Harazaki, Shinichi Kako, Shinsuke Iida, Tatsuo Ichinohe, Yoshinobu Kanda, Yoshiko Atsuta, Kazutaka Sunami; Multiple Myeloma Working Group in the Japanese Society for Transplantation and Cellular Therapy (Collaborative Group)

https://doi.org/10.3324/haematol.2023.283202

Ruxolitinib-based regimen in children with primary hemophagocytic lymphohistiocytosis (483 Online Views)

Jian Ge, Qing Zhang, Honghao Ma, Dong Wang, Yunze Zhao, Ting Zhu, Wenqian Wang, Chenxin Zhou, Ang Wei, Hongyun Lian, Maoquan Qin, Jun Yang, Zhigang Li, Tianyou Wang, Rui Zhang

https://doi.org/10.3324/haematol.2023.283478

Letters to the Editor

Final results and overall survival data from a phase II study of acalabrutinib monotherapy in patients with relapsed/refractory mantle cell lymphoma, including those with poor prognostic factors (1290 Online Views)

Steven Le Gouill, Monika Długosz-Danecka, Simon Rule, Pier Luigi Zinzani, Andre Goy, Stephen D. Smith, Jeanette K. Doorduijn, Carlos Panizo, Bijal D. Shah, Andrew J. Davies, Richard Eek, Eric Jacobsen, Arnon P. Kater, Tadeusz Robak, Preetesh Jain, Roser Calvo, Lin Tao, Michael Wang

https://doi.org/10.3324/haematol.2022.282469

Optimizing transplantation procedures through identification of prognostic factors in second remission for children with acute myeloid leukemia with no prior history of transplant (327 Online Views)

Hisashi Ishida, Shin-ichi Tsujimoto, Daisuke Hasegawa, Hirotoshi Sakaguchi, Shohei Yamamoto, Masakatsu Yanagimachi, Katsuyoshi Koh, Akihiro Watanabe, Asahito Hama, Yuko Cho, Kenichiro Watanabe, Maiko Noguchi, Masanobu Takeuchi, Junko Takita, Kana Washio, Keisuke Kato, Takashi Koike, Yoshiko Hashii, Ken Tabuchi, Moeko Hino, Yoshiko Atsuta, Yasuhiro Okamoto

https://doi.org/10.3324/haematol.2023.283203

Vaccine utilization and overwhelming post-splenectomy infection risk factors in two asplenia cohorts (273 Online Views)

Matthew A. Soderstrom, Mechelle A. Miller, Qing Wang, William P. Hennrikus, Nora L. Watson, Ryan C. Costantino, Matthew J. Bradley, V. Koneti Rao, Nathan A. Boggs

https://doi.org/10.3324/haematol.2023.283419

Myeloid lineage switch following CD7-targeted chimeric antigen receptor T-cell therapy in relapsed/refractory T-cell acute lymphoblastic leukemia (490 Online Views)

Ibrahim Aldoss, Parastou Tizro, Davsheen Bedi, James K. Mangan, Mary C. Clark, David Spencer, Joo Y. Song, Sindhu Cherian, Raju Pillai, Young Kim, Nitin Mahajan, Ketevan Gendzekhadze, Mike James, Kenneth Jacobs, Jan Davidson-Moncada, Stephen J. Forman, Huan-You Wang, Michelle Afkhami

https://doi.org/10.3324/haematol.2023.283566

Case Reports

Immune-related adverse events with bispecific T-cell engager therapy targeting B-cell maturation antigen (327 Online Views)

Bénédicte Piron, Mathilde Bastien, Chloé Antier, Romain Dalla-Torre, Bastien Jamet, Thomas Gastinne, Viviane Dubruille, Philippe Moreau, Jérôme Martin, Antoine Bénichou, Cyrille Touzeau, Benoît Tessoulin

https://doi.org/10.3324/haematol.2023.282919

Jul 13, 2023

Editorials
Article

Early splenectomy in a large cohort of children with sickle cell anemia: risks and consequences (396 Online Views)

Aimen Mechraoui, Ghislaine Ithier, Justine Pages, Zinedine Haouari, Liza Ali, Arnaud Bonnard, Malika Benkerrou, Florence Missud, Berengère Koehl, Laurent Holvoet, Enora Le Roux, Valentine Brousse

https://doi.org/10.3324/haematol.2022.282556

Editorials
Article

Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy (887 Online Views)

Ryotaro Nakamura, Bhavisha A. Patel, Soyoung Kim, F. Lennie Wong, Saro H. Armenian, Emma M. Groarke, Daniel A. Kessler, Kyle M. Hebert, Michael Heim, Mary Eapen, Neal S. Young

https://doi.org/10.3324/haematol.2023.282781

Editorials

Articles

Safety and efficacy of tenalisib in combination with romidepsin in patients with relapsed/refractory T-cell lymphoma: results from a phase I/II open-label multicenter study (464 Online Views)

Swaminathan P. Iyer, Auris Huen, Weiyun Z. Ai, Deepa Jagadeesh, Mary J. Lechowicz, Craig Okada, Tatyana A. Feldman, Paola Ghione, Juan P. Alderuccio, Rebecca Champion, Seo-Hyun Kim, Ann Mohrbacher, Kasi V. Routhu, Prajak Barde, Ajit M. Nair, Bradley M. Haverkos

https://doi.org/10.3324/haematol.2022.281875

Pro-inflammatory cells sustain leukemic clonal expansion in T-cell large granular lymphocyte leukemia (443 Online Views)

Cristina Vicenzetto, Vanessa Rebecca Gasparini, Gregorio Barila, Antonella Teramo, Giulia Calabretto, Elisa Rampazzo, Samuela Carraro, Valentina Trimarco, Livio Trentin, Monica Facco, Gianpietro Semenzato, Renato Zambello

https://doi.org/10.3324/haematol.2022.282306

IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma (409 Online Views)

Michael D. Pisano, Fumou Sun, Yan Cheng, Deepak Parashar, Vivian Zhou, Xuefang Jing, Ramakrishna Sompallae, Jenica Abrudan, Michael T. Zimmermann, Angela Mathison, Siegfried Janz, Miles A. Pufall

https://doi.org/10.3324/haematol.2022.282538

Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia (633 Online Views)

Edwin Quinten, Julieta H. Sepúlveda-Yáñez, Marvyn T. Koning, Janneke A. Eken, Dietmar Pfeifer, Valeri Nteleah, Ruben A.L. de Groen, Diego Alvarez Saravia, Jeroen Knijnenburg, Hedwig E. Stuivenberg-Bleijswijk, Milena Pantic, Andreas Agathangelidis, Andrea Keppler-Hafkemeyer, Cornelis A. M. van Bergen, Roberto Uribe-Paredes, Kostas Stamatopoulos, Joost S.P. Vermaat, Katja Zirlik, Marcelo A. Navarrete, Hassan Jumaa, Hendrik Veelken

https://doi.org/10.3324/haematol.2022.282542

Cancer-specific mortality in multiple myeloma: a population-based retrospective cohort study (397 Online Views)

Arleigh McCurdy, Hsien Seow, Gregory P. Pond, Anastasia Gayowsky, Rajshekhar Chakraborty, Alissa Visram, Rayan Kaedbey, Anita D’Souza, Ghulam Rehman Mohyuddin, Tanya M. Wildes, Rafael Fonseca, Hira Mian

https://doi.org/10.3324/haematol.2023.282905

Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation (315 Online Views)

Li Guo, Shancy Jacob, Bhanu Kanth Manne, E. Motunrayo Kolawole, Siqi Guo, Xiang Wang, Darian Murray, Emilia A. Tugolukova, Irina Portier, Yasuhiro Kosaka, Cindy Barba, Matthew T. Rondina, Brian Evavold, Celeste Morley, Seema Bhatlekar, Paul F. Bray

https://doi.org/10.3324/haematol.2023.283016

Disease associations with monoclonal gammopathy of undetermined significance can only be evaluated using screened cohorts: results from the population-based iStopMM study (573 Online Views)

Aðalbjörg Ýr Sigurbergsdóttir, Sæmundur Rögnvaldsson, Sigrún Thorsteinsdóttir, Ingigerður Sverrisdóttir, Guðrún Ásta Sigurðardóttir, Brynjar Viðarsson, Páll Torfi Önundarson, Bjarni A. Agnarsson, Margrét Sigurðardóttir, Ingunn Þorsteinsdóttir, Ísleifur Ólafsson, Ásdís Rósa Þórðardóttir, Gauti Kjartan Gíslason, Andri Ólafsson, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Ola Landgren, Thorvarður Jón Löve, Sigurður Yngvi Kristinsson

https://doi.org/10.3324/haematol.2023.283191

Elotuzumab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: a multicenter, retrospective real-world experience with 200 cases outside of controlled clinical trials (726 Online Views)

Massimo Gentile, Ernesto Vigna, Salvatore Palmieri, Monica Galli, Daniele Derudas, Roberto Mina, Roberta Della Pepa, Renato Zambello, Enrica Antonia Martino, Antonella Bruzzese, Silvia Mangiacavalli, Elena Zamagni, Catello Califano, Maurizio Musso, Concetta Conticello, Claudio Cerchione, Giuseppe Mele, Nicola Di Renzo, Massimo Offidani, Giuseppe Tarantini, Gloria Margiotta Casaluci, Angela Rago, Roberto Ria, Giuseppina Uccello, Gregorio Barilà, Gaetano Palumbo, Alessandra Pompa, Donatella Vincelli, Marino Brunori, Fabrizio Accardi, Valeria Amico, Angela Amendola, Raffaele Fontana, Velia Bongarzoni, Bernardo Rossini, Emilia Cotzia, Alessandro Gozzetti, Rita Rizzi, Nicola Sgherza, Eleonora Ferretti, Giuseppe Bertuglia, Davide Nappi, Maria Teresa Petrucci, Francesco Di Raimondo, Antonino Neri, Fortunato Morabito, Pellegrino Musto

https://doi.org/10.3324/haematol.2023.283251

DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification (558 Online Views)

Vanessa K. Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Giuseppina Fabbiano, Valentina Traini, Katia Todoerti, Silvia Erratico, Alessia Ciarrocchi, Valentina Fragliasso, Domenica Giannandrea, Francesca Tumiatti, Raffaella Chiaramonte, Yvan Torrente, Palma Finelli, Eugenio Morelli, Nikhil C. Munshi, Niccolò Bolli, Antonino Neri, Elisa Taìana

https://doi.org/10.3324/haematol.2023.283274

Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment (378 Online Views)

Angelo D’Alessandro, S. Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Julie A. Reisz, Xu Zhang, Kyle W. Bartsch, Matthew D. Galbraith, Joaquin M. Espinosa, Victor R. Gordeuk, Mark T. Gladwin

https://doi.org/10.3324/haematol.2023.283288

Daratumumab in first-line treatment of patients with light chain amyloidosis and Mayo stage IIIb improves treatment response and overall survival (611 Online Views)

Sara Oubari, Ute Hegenbart, Renate Schoder, Maximilian Steinhardt, Maria Papathanasiou, Tienush Rassaf, Andreas Thimm, Tim Hagenacker, Eyad Naser, Ulrich Duhrsen, Hans C. Reinhardt, Martin Kortum, Hermine Agis, Stefan Schonland, Alexander Carpinteiro

https://doi.org/10.3324/haematol.2023.283325

Letters to the Editor

Cross-intolerance with bosutinib after prior tyrosine kinase inhibitors for Philadelphia chromosome-positive leukemia: long-term analysis of a phase I/II study (618 Online Views)

Jorge E. Cortes, Jeff H. Lipton, Vamsi Kota, Fausto Castagnetti, Sarit Assouline, Tim H. Brümmendorf, Eric Leip, Andrea Viqueira, Carlo Gambacorti-Passerini

https://doi.org/10.3324/haematol.2022.281944

Modified carfilzomib dosing is associated with improved treatment responses and longer time on treatment in patients with multiple myeloma (385 Online Views)

Abdullah M. Khan, Kiatlyn Dvorak, Qiuhong Zhao, Naresh Bumma, Francesca Cottini, Srinivas Devarakonda, Elvira Umyarova, Nidhi Sharma, Don Benson, Ashley Rosko

https://doi.org/10.3324/haematol.2022.282521

Co-stimulatory and immune checkpoint molecules are important in the tumor microenvironment of Hodgkin-like adult T-cell leukemia/lymphoma (266 Online Views)

Mai Takeuchi, Hiroaki Miyoshi, Yuichiro Semba, Kyohei Yamada, Kazutaka Nakashima, Kensaku Sato, Takuya Furuta, Mayuko Moritsubo, Yusuke Ogura, Ken Tanaka, Teppei Imamoto, Fumiko Arakawa, Kei Kohno, Koichi Ohshima

https://doi.org/10.3324/haematol.2023.283163

Higher cyclophosphamide dose grants optimal stem-cell collection after daratumumab-based induction in multiple myeloma (581 Online Views)

Carmine Liberatore, Tommaso Perini, Cecilia Passeri, Valeria Ferla, Francesca Fioritoni, Virginia Girlando, Ornella Iuliani, Alessia Orsini, Guido Montanaro, Francesca Farina, Alessandro Di Nicola, Rosamaria Nitti, Stefano Pulini, Sara Mastaglio, Stella Santarone, Milena Coppola, Sarah Marktel, Patrizia Accorsi, Fabio Ciceri, Magda Marcatti, Mauro Di Ianni

https://doi.org/10.3324/haematol.2023.283452

Jul 6, 2023

Articles

Genomic analysis of venous thrombosis in children with acute lymphoblastic leukemia from diverse ancestries (399 Online Views)

Yan Zheng, Wenjian Yang, Jeremie Estepp, Deqing Pei, Cheng Cheng, Clifford M. Takemoto, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Mary V. Relling, Seth E. Karol

https://doi.org/10.3324/haematol.2022.281582

Haploidentical donor hematopoietic cell transplantation for myelodysplastic/myeloproliferative overlap neoplasms: results from a North American collaboration (737 Online Views)

Tania Jain, Hua-Ling Tsai, Hany Elmariah, Pankit Vachhani, Theodoros Karantanos, Sarah A Wall, Lukasz P. Gondek, Asad Bashey, Alla Keyzner, Roni Tamari, Michael R. Grunwald, Sameem Abedin, Kalyan VG Nadiminti, Madiha Iqbal, Aaron T Gerds, Auro Viswabandya, Shannon R McCurdy, Monzr M. Al Malki, Ravi Varadhan, Haris Ali, Vikas Gupta, Richard J. Jones, Salman Otoukesh

https://doi.org/10.3324/haematol.2023.283426

Letters to the Editor

An accessible patient-derived xenograft model of low-risk myelodysplastic syndromes (310 Online Views)

Patric Teodorescu, Sergiu Pasca, InYoung Choi, Cynthia Shams, W. Brian Dalton, Lukasz P. Gondek, Amy E. DeZern, Gabriel Ghiaur

https://doi.org/10.3324/haematol.2023.282967

Jun 29, 2023

Editorials
Article

B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma (715 Online Views)

Lorenz Thurner, Natalie Fadle, Evi Regitz, Sophie Roth, Onur Cetin, Igor Age Kos, Simon Mauro Hess, Julia Bein, Rainer Maria Bohle, Martine Vornanen, Christer Sundström, Laurence de Leval, Enrico Tiacci, Peter Borchmann, Andreas Engert, Viola Poeschel, Gerhard Held, Eva C. Schwarz, Frank Neumann, Klaus-Dieter Preuss, Markus Hoth, Ralf Küppers, Karola Lehman, Martin-Leo Hansmann, Sören L. Becker, Moritz Bewarder, Sylvia Hartmann

https://doi.org/10.3324/haematol.2023.282698

Articles

Lymphocyte migration and retention properties affected by ibrutinib in chronic lymphocytic leukemia (796 Online Views)

Javier Rey-Barroso, Alice Munaretto, Nelly Rouquié, Aurélie Mougel, Malika Chassan, Sébastien Gadat, Océane Dewingle, Renaud Poincloux, Sarah Cadot, Loïc Ysebaert, Anne Quillet-Mary, Loïc Dupré

https://doi.org/10.3324/haematol.2022.282466

Amyloidogenic light chains impair plasma cell survival (414 Online Views)

Marjorie Pick, Eyal Lebel, Sharona Elgavish, Hadar Benyamini, Yuval Nevo, Rachel Hertz, Jacob Bar-Tana, Paola Rognoni, Giampaolo Merlini, Moshe E. Gatt

https://doi.org/10.3324/haematol.2022.282484

Long non-coding RNA mitophagy and ALK anaplastic lymphoma associated transcript: a novel regulator of mitophagy in T cell lymphoma (526 Online Views)

Valentina Mularoni, Benedetta Donati, Annalisa Tameni, Veronica Manicardi, Francesca Reggiani, Elisabetta Sauta, Magda Zanelli, Marco Tigano, Emanuele Vitale, Federica Torricelli, Stefano Ascani, Giovanni Martino, Giorgio Inghirami, Francesca Sanguedolce, Alessia Ruffini, Alberto Bavieri, Stefano Luminari, Marco Pizzi, Angelo Paolo Dei Tos, Cinzia Fesce, Antonino Neri, Alessia Ciarrocchi, Valentina Fragliasso

https://doi.org/10.3324/haematol.2022.282552

Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients (926 Online Views)

Patrick Stelmach, Sarah Richter, Sandra Sauer, Margarete A. Fabre, Muxin Gu, Christian Rohde, Maike Janssen, Nora Liebers, Rumyana Proynova, Niels Weinhold, Marc S. Raab, Hartmut Goldschmidt, Birgit Besenbeck, Petra Pavel, Sascha Laier, Andreas Trumpp, Sascha Dietrich, George S. Vassiliou, Carsten Müller-Tidow

https://doi.org/10.3324/haematol.2023.282992

Letters to the Editor

ETV6 fusions from insertions of exons 3-5 in pediatric hematologic malignancies (275 Online Views)

Sarah B. Mueller, Yana Pikman, Sarah K. Tasian, Lewis B. Silverman, Marian H. Harris, Harrison K. Tsai

https://doi.org/10.3324/haematol.2022.282498

CD47 expression in acute myeloid leukemia varies according to genotype (885 Online Views)

Andrea Marra, Ayse U Akarca, Giovanni Martino, Alan Ramsay, Stefano Ascani, Vincenzo Maria Perriello, Jenny O’Nions, Andrew J Wilson, Rajeev Gupta, Anna Childerhouse, Ian Proctor, Manuel Rodriguez-Justo, Sabine Pomplun, Maria Paola Martelli, Cristina Lo Celso, Brunangelo Falini, Teresa Marafioti

https://doi.org/10.3324/haematol.2023.283154

Jun 22, 2023

Articles

Genomic breakpoint specific monitoring of measurable residual disease in pediatric non-standard risk acute myeloid leukemia (457 Online Views)

Margarita Maurer-Granofszky, Stefan Kohrer, Susanna Fischer, Angela Schumich, Karin Nebral, Patrizia Larghero, Claus Meyer, Astrid Mecklenbrauker, Nora Muhlegger, Rolf Marschalek, Oskar A. Haas, Renate Panzer-Grumayer, Michael N. Dworzak

https://doi.org/10.3324/haematol.2022.282424

Effect of age and treatment on predictive value of measurable residual disease: implications for clinical management of adult patients with acute myeloid leukemia (406 Online Views)

Francesco Mannelli, Matteo Piccini, Sara Bencini, Giacomo Gianfaldoni, Benedetta Peruzzi, Roberto Caporale, Barbara Scappini, Laura Fasano, Elisa Quinti, Gaia Ciolli, Andrea Pasquini, Francesca Crupi, Sofia Pilerci, Fabiana Pancani, Leonardo Signori, Danilo Tarantino, Chiara Maccari, Vivian Paradiso, Francesco Annunziato, Paola Guglielmelli, Alessandro M. Vannucchi

https://doi.org/10.3324/haematol.2023.283196

Letters to the Editor

Efficacy and toxicity of midostaurin with idarubicin and cytarabine induction in FLT3-mutated acute myeloid leukemia (332 Online Views)

Julia S. Lee, Charlotte B. Wagner, Stacy Prelewicz, Heena P. Kurish, Robert Walchack, Danielle A. Cenin, Seema Patel, Mimi Lo, Danielle Schlafer, Belinda K.T. Li, R. Donald Harvey III, Bestis Wasef, Jian Ying, Tibor Kovacsovics

https://doi.org/10.3324/haematol.2022.281967

Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway (248 Online Views)

Cuiping Zhang, Xiaojing Cui, Yi Liu, Fang Wang, Robert Signer, Kapana Nattamai, Daohong Zhou, Yi Zheng, Hartmut Geiger, Fengyi Wan, Ying Liang

https://doi.org/10.3324/haematol.2022.282028

CAR-T cell therapy for central nervous system lymphomas: blood and cerebrospinal fluid biology, and outcomes (389 Online Views)

Claire Lacan, Jonathan Caron, Nadine Tarantino, Baptiste Fouquet, Mustapha Cherai, Christophe Parizot, Véronique Morel, Laetitia Souchet, Madalina Uzunov, Guy Gorochov, Stéphanie Nguyen-Quoc, Elise Sourdeau, Vincent Vieillard, Makoto Miyara, Angélique Vinit, Silvia Solorzano, Carole Soussain, Caroline Houillier, Carole Metz, Brigitte Autran, Elena Litvinova, Magali Le Garff-Tavernier, Françoise Norol, Damien Roos-Weil, Sylvan Choquet, Amélie Guihot, Marine Baron

https://doi.org/10.3324/haematol.2023.282875

Exclusion of persistent mutations in splicing factor genes and isocitrate dehydrogenase 2 improves the prognostic power of molecular measurable residual disease assessment in acute myeloid leukemia (353 Online Views)

Tracy Murphy, Jinfeng Zou, Andrea Arruda, Ting Ting Wang, Zhen Zhao, Yangqiao Zheng, Vikas Gupta, Dawn Maze, Caroline McNamara, Mark D. Minden, Aaron Schimmer, Hassan Sibai, Karen Yee, Jose-Mario Capo-Chichi, Tracy Stockley, Andre Schuh, Scott V. Bratman, Steven M. Chan

https://doi.org/10.3324/haematol.2023.283510

Jun 15, 2023

Editorials
Article

Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia (493 Online Views)

Janina Heilmann, Simon Vieth, Anja Möricke, Andishe Attarbaschi, Draga Barbaric, Nicole Bodmer, Antonella Colombini, Luciano Dalla-Pozza, Sarah Elitzur, Shai Izraeli, Georg Mann, Felix Niggli, Daniela Silvestri, Jan Stary, Carmelo Rizzari, Maria Grazia Valsecchi, Ester Zapotocka, Martin Zimmermann, Gunnar Cario, Martin Schrappe, Valentino Conter

https://doi.org/10.3324/haematol.2022.281788

Articles

Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation (716 Online Views)

Ahmed Waraky, Anders Östlund, Tina Nilsson, Dieter Weichenhan, Pavlo Lutsik, Marion Bähr, Joschka Hey, Gürcan Tunali, Jenni Adamsson, Susanna Jacobsson, Mohammad Hamdy Abdelrazak Morsy, Susann Li, Linda Fogelstrand, Christoph Plass, Lars Palmqvist

https://doi.org/10.3324/haematol.2022.282255

Letters to the Editor

Hematological abnormalities in Jacobsen syndrome: Cytopenia of varying severities and morphological abnormalities in peripheral blood and bone marrow (378 Online Views)

Daiki Yamashita, Hideki Muramatsu, Atsushi Narita, Manabu Wakamatsu, Yusuke Tsumura, Daichi Sajiki, Ryo Maemura, Ayako Yamamori, Masayuki Imaya, Kotaro Narita, Shinsuke Kataoka, Rieko Taniguchi, Nobuhiro Nishio, Yusuke Okuno, Naoto Fujita, Katsuyoshi Koh, Katsutsugu Umeda, Eiji Morihana, Hideto Iwafuchi, Masafumi Ito, Seiji Kojima, Asahito Hama, Yoshiyuki Takahashi

https://doi.org/10.3324/haematol.2022.282513

Specific blood monocyte distribution in histiocytoses correlates with vascular involvement and disease activity (340 Online Views)

Jerome Razanamahery, Maxime Samson, Julien Guy, Jessica Racine, Celine Row, Hélène Greigert, Barbara Nicolas, Stephanie Francois, Jean-François Emile, Fleur Cohen-Aubart, Sylvain Audia, Julien Haroche, Bernard Bonnotte

https://doi.org/10.3324/haematol.2023.282739

Mechanisms of endothelial injury and transplant-associated thrombotic microangiopathy in tandem autologous hematopoietic stem cell transplant for neuroblastoma (373 Online Views)

Anthony Sabulski, Sheyar Abdullah, Nathan Luebbering, Benjamin Aunins, Caitlin Castillo, Kelly Lake, Alexandra Duell, Lauren Strecker, Lucille Langenberg, William Broomhead, Scott DiMeo, Elizabeth A. Odegard, Jason T. Blackard, Assem G. Ziady, Alix E. Seif, Christopher E. Dandoy, Benjamin L. Laskin, Sonata Jodele, Stella M. Davies

https://doi.org/10.3324/haematol.2023.283351

Jun 1, 2023

Review Articles

Articles

Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or immunosuppressive therapy (887 Online Views)

Ryotaro Nakamura, Bhavisha A. Patel, Soyoung Kim, F. Lennie Wong, Saro H. Armenian, Emma M. Groarke, Daniel A. Kessler, Kyle M. Hebert, Michael Heim, Mary Eapen, Neal S. Young

https://doi.org/10.3324/haematol.2023.282781

Letters to the Editor

Prognostic value of early PET in patients with large B-cell lymphoma treated with anti-CD19 CAR T-cell therapy (477 Online Views)

Jennifer L. Crombie, Caron A. Jacobson, Robert Redd, Geoffrey Shouse, Alex F. Herrera, Victor A. Chow, Jordan Gauthier, Erin Mullane, Kirk Cahill, Justin Kline, Jason Romancik, Jonathon B. Cohen, Anna Saucier, Roch Houot, Philippe Armand, Brian Hess

https://doi.org/10.3324/haematol.2022.282345

Clinical outcomes of patients with myelofibrosis after immediate transition to momelotinib from ruxolitinib (1605 Online Views)

Ruben Mesa, Srdan Verstovsek, Uwe Platzbecker, Vikas Gupta, David Lavie, Pilar Giraldo, Christian Recher, Jean-Jacques Kiladjian, Stephen T. Oh, Aaron T. Gerds, Timothy Devos, Francesco Passamonti, Alessandro M. Vannucchi, Miklos Egyed, Ewa Lech-Maranda, Andrzej Pluta, Lars Nilsson, Kazuya Shimoda, Donal McLornan, Jun Kawashima, Barbara Klencke, Mei Huang, Bryan Strouse, Claire Harrison

https://doi.org/10.3324/haematol.2023.283106

May 25, 2023

Articles

Early splenectomy in a large cohort of children with sickle cell anemia: risks and consequences (396 Online Views)

Aimen Mechraoui, Ghislaine Ithier, Justine Pages, Zinedine Haouari, Liza Ali, Arnaud Bonnard, Malika Benkerrou, Florence Missud, Berengère Koehl, Laurent Holvoet, Enora Le Roux, Valentine Brousse

https://doi.org/10.3324/haematol.2022.282556

Patient-reported treatment response in chronic graft-versus-host disease (520 Online Views)

Annie Im, Iskra Pusic, Lynn Onstad, Carrie L. Kitko, Betty K. Hamilton, Amin M. Alousi, Mary E. Flowers, Stefanie Sarantopoulos, Paul Carpenter, Jennifer White, Sally Arai, Najla El Jurdi, George Chen, Corey Cutler, Stephanie Lee, Joseph Pidala

https://doi.org/10.3324/haematol.2023.282734

May 18, 2023

Articles

Adenosine signaling inhibits erythropoiesis and promotes myeloid differentiation (534 Online Views)

Mahmoud Mikdar, Marion Serra, Elia Colin, Romain Duval, Emilie-Fleur Gauthier, Yann Lamarre, Yves Colin, Caroline Le Van Kim, Thierry Peyrard, Bérengère Koehl, Slim Azouzi

https://doi.org/10.3324/haematol.2022.281823

Outcomes after intensive chemotherapy for secondary and myeloidrelated changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry (557 Online Views)

David Martínez-Cuadrón, Juan E. Megías-Vericat, Cristina Gil, Teresa Bernal, Mar Tormo, Pilar Martínez-Sánchez, Carlos Rodríguez-Medina, Josefina Serrano, Pilar Herrera, José A. Pérez Simón, María J. Sayas, Juan Bergua, Esperanza Lavilla-Rubira, Maria Luz Amigo, Celina Benavente, Jose L. López Lorenzo, Manuel M. Pérez-Encinas, María B. Vidriales, Mercedes Colorado, Beatriz de Rueda, Raimundo García-Boyero, Sandra Marini, Julio García-Suárez, María López-Pavía, Maria I. Gómez-Roncero, Víctor Noriega, Aurelio López, Jorge Labrador, Ana Cabello, Claudia Sossa, Lorenzo Algarra, Mariana Stevenazzi, Antonio Solana-Altabella, Blanca Boluda, Pau Montesinos

https://doi.org/10.3324/haematol.2022.282506

Current use of androgens in bone marrow failure disorders: a report from the Severe Aplastic Anemia Working Party of the European Society of Blood and Marrow Transplantation (1593 Online Views)

Simona Pagliuca, Austin G. Kulasekararaj, Dirk-Jan Eikema, Brian Piepenbroek, Raheel Iftikhar, Tariq Mahmood Satti, Morag Griffin, Marica Laurino, Alphan Kupesiz, Yves Bertrand, Bruno Fattizzo, Ibrahim Yakoub-Agha, Mahmoud Aljurf, Paola Corti, Erika Massaccesi, Bruno Lioure, Marisa Calabuig, Matthias Klammer, Emel Unal, Depei Wu, Patrice Chevallier, Edouard Forcade, John A. Snowden, Hakan Ozdogu, Antonio Risitano, Régis Peffault de Latour

https://doi.org/10.3324/haematol.2023.282935

Impact of viral hepatitis therapy in multiple myeloma and other monoclonal gammopathies linked to hepatitis B or C viruses (543 Online Views)

Alba Rodríguez-García, Nicolas Mennesson, Gema Hernandez-Ibarburu, María Luz Morales, Laurent Garderet, Lorine Bouchereau, Sophie Allain-Maillet, Eric Piver, Irene Marbán, David Rubio, Edith Bigot-Corbel, Joaquín Martínez-López, María Linares, Sylvie Hermouet

https://doi.org/10.3324/haematol.2023.283096

Comments

May 4, 2023

Articles

B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma (715 Online Views)

Lorenz Thurner, Natalie Fadle, Evi Regitz, Sophie Roth, Onur Cetin, Igor Age Kos, Simon Mauro Hess, Julia Bein, Rainer Maria Bohle, Martine Vornanen, Christer Sundström, Laurence de Leval, Enrico Tiacci, Peter Borchmann, Andreas Engert, Viola Poeschel, Gerhard Held, Eva C. Schwarz, Frank Neumann, Klaus-Dieter Preuss, Markus Hoth, Ralf Küppers, Karola Lehman, Martin-Leo Hansmann, Sören L. Becker, Moritz Bewarder, Sylvia Hartmann

https://doi.org/10.3324/haematol.2023.282698

Letters to the Editor

Apr 27, 2023

Case Reports

Apr 6, 2023

Articles

Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia (493 Online Views)

Janina Heilmann, Simon Vieth, Anja Möricke, Andishe Attarbaschi, Draga Barbaric, Nicole Bodmer, Antonella Colombini, Luciano Dalla-Pozza, Sarah Elitzur, Shai Izraeli, Georg Mann, Felix Niggli, Daniela Silvestri, Jan Stary, Carmelo Rizzari, Maria Grazia Valsecchi, Ester Zapotocka, Martin Zimmermann, Gunnar Cario, Martin Schrappe, Valentino Conter

https://doi.org/10.3324/haematol.2022.281788

Mar 23, 2023

Spotlight Review

Mar 9, 2023

Articles

Impact of central nervous system involvement in adult patients with Philadelphia-negative acute lymphoblastic leukemia: a GRAALL-2005 study (526 Online Views)

Corentin Orvain, Sylvain Chantepie, Xavier Thomas, Martine Escofrre-Barbe, Francoise Huguet, Yohan Desbrosses, Gaelle Guillerm, Madalina Uzunov, Thibaut Leguay, Sarah Barbieux, Norbert Vey, Patrice Chevallier, Jean-Valere Malfuson, Stephane Lepretre, Michael Baumann, Murat Aykut, Abdelaziz Chaib, Magalie Joris, Hacene Zerazhi, Georg Stussi, Jacques Chapiro, Celine Berthon, Caroline Bonmati, Eric Jourdan, Diana Carp, Amb roise Marcais, Maria-Pilar Gallego-Hernanz, Iona Vaida, Karin Bilger, Alban Villate, Florence Pasquier, Yves Chalandon, Sebastien Maury, Veronique Lheritier, Norbert Ifrah, Herve Dombret, Nicolas Boissel, Mathilde Hunault-Berger.

https://doi.org/10.3324/haematol.2022.282332

Aug 19, 2021

Errata Corrige

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (3356 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2021.279802

May 10, 2018

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells (1252 Online Views)

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

https://doi.org/10.3324/haematol.2018.189399