Early view

Jun 20, 2024

Articles

A first-in-class Wiskott-Aldrich syndrome protein activator with anti-tumor activity in hematologic cancers (107 Online Views)

Filippo Spriano, Giulio Sartori, Jacopo Sgrignani, Laura Barnabei, Alberto J. Arribas, Matilde Guala, Ana Maria Carrasco Del Amor, Meagan R. Tomasso, Chiara Tarantelli, Luciano Cascione, Gaetanina Golino, Maria E Riveiro, Roberta Bortolozzi, Antonio Lupia, Francesco Paduano, Samuel Huguet, Keyvan Rezai, Andrea Rinaldi, Francesco Margheriti, Pedro Ventura, Greta Guarda, Giosuè Costa, Roberta Rocca, Alberto Furlan, Luuk M. Verdonk, Paolo Innocenti, Nathaniel I. Martin, Giampietro Viola, Christoph Driessen, Emanuele Zucca, Anastasios Stathis, Digvijay Gahtory, Maurits van den Nieuwboer, Beat Bornhauser, Stefano Alcaro, Francesco Trapasso, Susana Cristobal, Shae B. Padrick, Natalina Pazzi, Franco Cavalli, Andrea Cavalli, Eugenio Gaudio, Francesco Bertoni

https://doi.org/10.3324/haematol.2022.282672

Anti-CD19 chimeric antigen receptor T-cell therapy has less efficacy in Richter transformation than in de novo large B-cell lymphoma and transformed low-grade B-cell lymphoma (267 Online Views)

Ohad Benjamini, Shalev Fried, Roni Shouval, Jessica R. Flynn, Ofrat Beyar-Katz, Lori A Leslie, Tsilla Zucherman, Ronit Yerushalmi, Noga Shem-Tov, Maria Lia Palomba, Ivetta Danylesko, Inbal Sdayoor, Hila Malka, Orit Itzhaki, Hyung Suh, Sean M. Devlin, Ronit Marcus, Parastoo B Dahi, Elad Jacoby, Gunjan L Shah, Craig S Sauter, Andrew Ip, Miguel-Angel Perales, Arnon Nagler, Avichai Shimoni, Michael Scordo, Abraham Avigdor

https://doi.org/10.3324/haematol.2023.284664

Brexucabtagene autoleucel in relapsed or refractory mantle cell lymphoma, intention-to-treat use in the DESCAR-T registry (83 Online Views)

Charles Herbaux, Caroline Bret, Emmanuel Bachy, Pierre Bories, Roberta Di Blasi, Alexis Cuffel, Thomas Gastinne, Thierry Lamy, Mikael Roussel, Krimo Bouabdallah, David Beauvais, Guillaume Cartron, Jacques-Olivier Bay, Didier Blaise, Marie-Therese Rubio, Mohamad Mohty, Fabien Le Bras, Olivier Casasnovas, Julien Guy, Stephanie Guidez, Cristina Castilla Llorente, Olivier Hermine, Laurianne Drieu La Rochelle, Sylvain Carras, Blandine Guffroy, Sophie Caillat-Zucman, Roch Houot, Steven Le Gouill

https://doi.org/10.3324/haematol.2023.284786

Decision analysis for transplant candidates with primary myelofibrosis in the ruxolitinib era (64 Online Views)

Yosuke Okada, Hideki Nakasone, Shunto Kawamura, Kosuke Takano, Kazuki Yoshimura, Masaharu Tamaki, Akari Matsuoka, Takuto Ishikawa, Tomohiro Meno, Yuhei Nakamura, Masakatsu Kawamura, Junko Takeshita, Nozomu Yoshino, Yukiko Misaki, Machiko Kusuda, Aki Tanihara, Shun-ichi Kimura, Shinichi Kako, Yoshinobu Kanda

https://doi.org/10.3324/haematol.2024.285256

Letters to the Editor

FLT3 inhibitors potentially improve response rates in acute myeloid leukemia harboring t(6;9)(DEK::NUP214): The Mayo Clinic experience (21 Online Views)

Clifford M. Csizmar, Antoine N. Saliba, Patricia T. Greipp, Hassan Alkhateeb, Kebede H. Begna, James M. Foran, Naseema Gangat, William J. Hogan, C. Christopher Hook, Mark R. Litzow, Abhishek A. Mangaonkar, Jeanne M. Palmer, Animesh Pardanani, Mithun V. Shah, Ayalew Tefferi, Mehrdad Hefazi Torghabeh, Alexandra P. Wolanskyj-Spinner, Mrinal M. Patnaik, Scott H Kaufmann, Aref Al-Kali

https://doi.org/10.3324/haematol.2024.285359

ASXL1/TET2 genotype-based risk stratification outperforms ASXL1 mutational impact and is independent of mutant variant allele fractions in chronic myelomonocytic leukemia (67 Online Views)

Clifford M. Csizmar, Mark Gurney, Rashmi Kanagal-Shamanna, Kelly Chien, Danielle Hammond, Terra L. Lasho, Christy M. Finke, Christopher Dean, Anuya Natu, Abhishek A. Mangaonkar, Aref Al-Kali, Naseema Gangat, Ayalew Tefferi, Hassan Alkhateeb, Guillermo Garcia-Manero, Rami S. Komrokji, Najla A. Ali, Eric Padron, Guillermo Montalban-Bravo, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2024.285410

Jun 13, 2024

Review Articles

Articles

Event-free survival at 36 months is a suitable endpoint for diffuse large B-cell lymphoma patients treated with immunochemotherapy: real-world evidence from the North Japan Hematology Study Group (212 Online Views)

Koh Izumiyama, Tasuku Inao, Hideki Goto, Shinpei Harada, Hajime Senjo, Keito Suto, Junichi Hashiguchi, Reiki Ogasawara, Tomoyuki Saga, Tetsuyuki Igarashi, Kentaro Wakasa, Ikumi Kasahara, Yukari Takeda, Keisuke Yamaguchi, Akio Shigematsu, Mutsumi Takahata, Katsuya Fujimoto, Yoshihito Haseyama, Takahiro Nagashima, Hajime Sakai, Yasutaka Kakinoki, Mitsutoshi Kurosawa, Isao Yokota, Takanori Teshima

https://doi.org/10.3324/haematol.2023.284841

Azacitidine as epigenetic priming for chemotherapy is safe and well-tolerated in infants with newly diagnosed KMT2A-rearranged acute lymphoblastic leukemia: Children’s Oncology Group trial AALL15P1 (166 Online Views)

Erin M. Guest, John A. Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly R. Kubaney, Margaret A. August, Sidharth Ramesh, Byunggil Yoo, Midhat S. Farooqi, Melinda G. Pauly, Daniel S. Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia D. Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown

https://doi.org/10.3324/haematol.2024.285158

Letters to the Editor

PD-1 blockade and allogeneic hematopoietic stem cell transplantation in Hodgkin lymphoma, a matter of time: a national study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (113 Online Views)

Eleonore Kaphan, Francois Bettega, Nicolas Vallet, Nathalie Fegueux, Marie Robin, Ali Bazarbachi, Stephanie Nguyen, David Beauvais, Edouard Forcade, Maria Carolina Montes De Oca, Raynier Devillier, Patrice Chevallier, Michael Loschi, Anne Huynh, Jacques-Olivier Bay, Marie-Therese Rubio, Felipe Suarez, Sylvie Francois, Xavier Poire, Nathalie Contentin, Deborah Desmier, Amandine Charbonnier, Jerome Cornillon, Sylvain Chantepie, Pascal Turlure, Claude-Eric Bulabois, David Michonneau, Alban Villate; SFGM-TC (Collaborative Group)

https://doi.org/10.3324/haematol.2024.284968

Changes in sex-specific incidence of lymphoid neoplasms across the lifespan (61 Online Views)

Bryan Valcarcel, Sara J. Schonfeld, Sarah S. Jackson, Graça M. Dores, Martha S. Linet, Lindsay M. Morton

https://doi.org/10.3324/haematol.2024.285281

Soluble SLAMF7 is generated by alternative splicing in multiple myeloma cells (124 Online Views)

Jiro Kikuchi, Mitsuo Hori, Naoki Osada, Sae Matsuoka, Atsushi Suzuki, Satoshi Kakugawa, Hiroshi Yasui, Takeshi Harada, Hirofumi Tenshin, Masahiro Abe, Hideki Nakasone, Yusuke Furukawa

https://doi.org/10.3324/haematol.2024.285368

De-escalation of corticosteroids and clonal remission in UBA1 mutation-driven VEXAS syndrome with 5-azacytidine (99 Online Views)

Roochi Trikha, Kar Lok Kong, James Galloway, Tanya N. Basu, Lynn Quek, Jamie Wilson, Louise Gamble, Henna Wong, Steven Best, Austin Kulasekararaj

https://doi.org/10.3324/haematol.2024.285519

Jun 6, 2024

Articles

Long-term efficacy and safety of tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: final analysis of phase IIb results (295 Online Views)

Shinya Rai, Won Seog Kim, Kiyoshi Ando, Ilseung Choi, Koji Izutsu, Norifumi Tsukamoto, Dai Maruyama, Kunihiro Tsukasaki, Junya Kuroda, Jun Ando, Michihiro Hidaka, Youngil Koh, Hisashi Kato, Toshiki Uchida, Deok Hwan Yang, Kenji Ishitsuka, Kenichi Ishizawa, Jin Seok Kim, Hong Ghi Lee, Hironobu Minami, Hyeon Seok Eom, Mitsutoshi Kurosawa, Jae Hoon Lee, Jong Seok Lee, Won Sik Lee, Hirokazu Nagai, Takero Shindo, Dok Hyun Yoon, Shinichiro Yoshida, Mireille Gillings, Hiroshi Onogi, Kensei Tobinai

https://doi.org/10.3324/haematol.2023.283992

Epstein-Barr Virus and immune status imprint the immunogenomics of non-Hodgkin lymphomas occurring in immune-suppressed environments (258 Online Views)

Marine Baron, Karim Labreche, Marianne Veyri, Nathalie Désiré, Amira Bouzidi, Fatou Seck-Thiam, Frédéric Charlotte, Alice Rousseau, Véronique Morin, Cécilia Nakid-Cordero, Baptiste Abbar, Alberto Picca, Marie Le Cann, Noureddine Balegroune, Nicolas Gauthier, Ioannis Theodorou, Mehdi Touat, Véronique Morel, Franck Bielle, Assia Samri, Agusti Alentorn, Marc Sanson, Damien Roos-Weil, Corinne Haioun, Elsa Poullot, Anne Langlois de Septenville, Frédéric Davi, Amélie Guihot, Pierre-Yves Boelle, Véronique Leblond, Florence Coulet, Jean-Philippe Spano, Sylvain Choquet, Brigitte Autran; IDeATIon study group (Collaborative Group)

https://doi.org/10.3324/haematol.2023.284332

IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia (213 Online Views)

Britt M. T. Vervoort, Miriam Butler, Kari J.T. Grünewald, Dorette S. van Ingen Schenau, Trisha M. Tee, Luc Lucas, Alwin D. R. Huitema, Judith M. Boer, Beat C. Bornhauser, Jean-Pierre Bourquin, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen

https://doi.org/10.3324/haematol.2023.284357

Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma (435 Online Views)

Nicholas Davies, Tegan Francis, Ceri Oldreive, Maria Azam, Jordan Wilson, Philip J. Byrd, Megan Burley, Archana Sharma-Oates, Peter Keane, Sael Alatawi, Martin R. Higgs, Zbigniew Rudzki, Maha Ibrahim, Tracey Perry, Angelo Agathaggelou, Anne-Marie Hewitt, Edward Smith, Constanze Bonifer, Mark O’Connor, Josep V. Forment, Paul G. Murray, Eanna Fennell, Gemma Kelly, Catherine Chang, Grant S. Stewart, Tatjana Stankovic, Marwan Kwok, Alexander Malcolm Taylor

https://doi.org/10.3324/haematol.2023.284404

Asciminib stands out as the superior tyrosine kinase inhibitor to combine with anti-CD20 monoclonal antibodies for the treatment of CD20+ Philadelphia-positive B-cell precursor acute lymphoblastic leukemia in preclinical models (307 Online Views)

Krzysztof Domka, Agnieszka Dąbkowska, Martyna Janowska, Zuzanna Urbańska, Agata Pastorczak, Magdalena Winiarska, Klaudyna Fidyt, Mieszko Lachota, Elżbieta Patkowska, Łukasz Sędek, Bartosz Perkowski, Jaromir Hunia, Justyna Jakubowska, Beata Krzymieniewska, Ewa Lech-Marańda, Wojciech Młynarski, Tomasz Szczepański, Małgorzata Firczuk

https://doi.org/10.3324/haematol.2023.284853

Impact of genetic alterations on central nervous system progression of primary vitreoretinal lymphoma (181 Online Views)

Kota Yoshifuji, Daichi Sadato, Takashi Toya, Yotaro Motomura, Chizuko Hirama, Hiroshi Takase, Kouhei Yamamoto, Yuka Harada, Takehiko Mori, Toshikage Nagao

https://doi.org/10.3324/haematol.2023.284953

Factor VIII promotes angiogenesis and vessel stability regulating extracellular matrix proteins (174 Online Views)

Cristina Olgasi, Alessia Cucci, Ivan Molineris, Simone Assanelli, Francesca Anselmi, Chiara Borsotti, Chiara Sgromo, Andrea Lauria, Simone Merlin, Gillian E. Walker, Salvatore Oliviero, Antonia Follenzi

https://doi.org/10.3324/haematol.2024.285089

Superior outcomes and high-risk features with carfilzomib, lenalidomide, and dexamethasone combination therapy for patients with relapsed and refractory multiple myeloma: Results of the multicenter KMMWP2201 study (282 Online Views)

Ji Hyun Lee, Jimin Choi, Chang-Ki Min, Sung-Soo Park, Jae-Cheol Jo, Yoo Jin Lee, Jin Seok Kim, Hyeon-Seok Eom, Jongheon Jung, Joon Ho Moon, Hee Jeong Cho, Myung-won Lee, Sung-Soo Yoon, Ja Min Byun, Jae Hoon Lee, Je-Jung Lee, Sung-Hoon Jung, Ho-Jin Shin, Do Young Kim, Jun Ho Yi, Seung-Shin Lee, Young Rok Do, Dok Hyun Yoon, Hyungwoo Cho, Won Sik Lee, Ho Sup Lee, Jieun Uhm, Hyo Jung Kim, Hee Ryeong Jang, Sung-Hyun Kim, Kihyun Kim

https://doi.org/10.3324/haematol.2024.285534

Letters to the Editor

May 30, 2024

Editorials
Article

A predictive classifier of poor prognosis in transplanted patients with juvenile myelomonocytic leukemia: a study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (469 Online Views)

Déborah Meyran, Chloé Arfeuille, Sylvie Chevret, Quentin Neven, Aurélie Caye-Eude, Elodie Lainey, Arnaud Petit, Fanny Rialland, Gérard Michel, Dominique Plantaz, Charlotte Jubert, Alexandre Theron, Virginie Gandemer, Marie Ouachée-Chardin, Catherine Paillard, Bénédicte Bruno, Nimrod Buchbinder, Cécile Pochon, Charlotte Calvo, Mony Fahd, André Baruchel, Hélène Cavé, Jean-Hugues Dalle, Marion Strullu

https://doi.org/10.3324/haematol.2023.284103

Spotlight Review

Articles

The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival (259 Online Views)

Vesna S. Stanulović, Shorog Al Omair, Michelle A.C. Reed, Jennie Roberts, Sandeep Potluri, Taylor Fulton-Ward, Nancy Gudgeon, Emma L. Bishop, Juliette Roels, Tracey A. Perry, Sovan Sarkar, Guy Pratt, Tom Taghon, Sarah Dimeloe, Ulrich L. Günther, Christian Ludwig, Maarten Hoogenkamp

https://doi.org/10.3324/haematol.2023.283471

Deep phenotyping of nodal T-cell lymphomas reveals immune alterations and therapeutic targets (230 Online Views)

Pierre Stephan, Jimmy Perrot, Allison Voisin, Maud Barbery, Thibault Andrieu, Maxime Grimont, Julie Caramel, Mathilde Bardou, Garance Tondeur, Edoardo Missiaglia, Philippe Gaulard, François Lemmonier, Laurence de Leval, Emmanuel Bachy, Pierre Sujobert, Laurent Genestier, Alexandra Traverse-Glehen, Yenkel Grinberg-Bleyer

https://doi.org/10.3324/haematol.2023.284448

Mucosal-associated invariant T cells are functionally impaired in pediatric and young adult patients following allogeneic hematopoietic stem cell transplantation and their recovery correlates with clinical outcomes (475 Online Views)

Federica Galaverna, Sara Flamini, Carmen Dolores De Luca, Ilaria Pili, Emilia Boccieri, Francesca Benini, Francesco Quagliarella, Chiara Rosignoli, Marco Rosichini, Shirley Genah, Marialuigia Catanoso, Antonella Cardinale, Gabriele Volpe, Marianna Coccetti, Angela Pitisci, Giuseppina Li Pira, Roberto Carta, Barbarella Lucarelli, Francesca Del Bufalo, Valentina Bertaina, Marco Becilli, Daria Pagliara, Mattia Algeri, Pietro Merli, Franco Locatelli, Enrico Velardi

https://doi.org/10.3324/haematol.2023.284649

Management of complications of chimeric antigen receptor T-cell therapy: a report by the European Society of Blood and Marrow Transplantation (607 Online Views)

Olaf Penack, Christophe Peczynski, William Boreland, Daniel Wolff, Ivan Moiseev, Hélène Schoemans, Christian Koenecke, Charlotte Graham, Zinaida Peric

https://doi.org/10.3324/haematol.2023.284810

Prognostic impact of ‘multi-hit’ versus ‘single hit’ TP53 alteration in patients with acute myeloid leukemia: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (704 Online Views)

Talha Badar, Ahmad Nanaa, Ehab Atallah, Rory M. Shallis, Emily C. Craver, Zhuo Li, Aaron D. Goldberg, Antoine N. Saliba, Anand Patel, Jan P. Bewersdorf, Adam Duvall, Madelyn Burkart, Danielle Bradshaw, Yasmin Abaza, Maximilian Stahl, Neil Palmisiano, Guru Subramanian Guru Murthy, Amer M. Zeidan, Vamsi Kota, Mrinal M. Patnaik, Mark R. Litzow

https://doi.org/10.3324/haematol.2024.285000

LILRB4 represents a promising target for immunotherapy by dual targeting tumor cells and myeloid-derived suppressive cells in multiple myeloma (529 Online Views)

Lixin Gong, Hao Sun, Lanting Liu, Xiyue Sun, Teng Fang, Zhen Yu, Weiwei Sui, Jingyu Xu, Tingyu Wang, Fangshuo Feng, Lei Lei, Wei Rui, Yuxuan Liu, Xueqiang Zhao, Gang An, Xin Lin, Lugui Qiu, Mu Hao

https://doi.org/10.3324/haematol.2024.285099

The role of PALLD-STAT3 interaction in megakaryocyte differentiation and thrombocytopenia treatment (249 Online Views)

Guoming Li, Haojie Jiang, Lingbin Wang, Tingting Liang, Chen Ding, Mina Yang, Yingzhi Shen, Min Xin, Lin Zhang, Jing Dai, Xueqing Sun, Xuejiao Chen, Junling Liu, Yanyan Xu

https://doi.org/10.3324/haematol.2024.285242

Letters to the Editor

Validation and molecular integration of the RR6 model to predict survival after 6 months of therapy with ruxolitinib (247 Online Views)

Giacomo Coltro, Giulio Capecchi, Margherita Maffioli, Francesco Mannelli, Barbara Mora, Alessandro Atanasio, Alessandra Iurlo, Chiara Maccari, Mirko Farina, Elena Nacca, Marianna Caramella, Leonardo Signori, Miriam Borella, Lorenza Bertù, Maria Esposito, Paola Guglielmelli, Francesco Passamonti, Alessandro Maria Vannucchi

https://doi.org/10.3324/haematol.2024.285098

CCL22 mutations in large granular lymphocytic leukemia (136 Online Views)

Yuga Mizuno, Toru Kawakami, Daigo Higano, Shotaro Miyairi, Ami Asakura, Fumihiro Kawakami, Keijiro Sato, Shuji Matsuzawa, Sayaka Nishina, Hitoshi Sakai, Yumiko Higuchi, Kazuyuki Matsuda, Hideyuki Nakazawa, Fumihiro Ishida

https://doi.org/10.3324/haematol.2024.285404

Infrequent fractures and resilient bone mineral density: bone health in patients with Fanconi anemia (113 Online Views)

Jane Koo, Jonathan C. Howell, Lindsey Hornung, Anthony Sabulski, Parinda A. Mehta, Stella M. Davies, Kasiani C. Myers

https://doi.org/10.3324/haematol.2024.285612

Case Reports

Treatment strategies for progressive immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome: case series (266 Online Views)

Jack J. Scala, Michael J. Eckrich, Keagan Lipak, Bonnie Yates, Constance Yuan, Hao-Wei Wang, Saurabh Dahiya, Jan-Inge Henter, Jeffrey S. Huo, Matthew J. Frank, Nirali N. Shah

https://doi.org/10.3324/haematol.2023.284784

Late-onset NPM1 mutation in a MYC-amplified relapsed/refractory acute myeloid leukemia patient treated with gemtuzumab ozogamicin and glasdegib (288 Online Views)

Sonia Jaramillo, Michael Scherer, Chelsea Szu-Tu, Sergi Beneyto-Calabuig, Carsten Müller-Tidow, Richard F. Schlenk, Michael Hundemer, Lars Velten, Caroline Pabst

https://doi.org/10.3324/haematol.2023.284922

Myeloid neoplasm with histiocytosis and spleen tyrosine kinase fusion responds to fostamatinib (284 Online Views)

Zachary Risch, Benjamin H. Kaffenberger, Catherine G. Chung, Eric Samorodnitsky, Emily L. Hoskins, Thuy Dao, Amy Smith, Sarah A. Wall, Jonathan Brammer, Julie W. Reeser, Michele R. Wing, Julia F. Hopkins, Lee A. Albacker, Lynne V. Abruzzo, Caprice D. Eisele, Aharon G. Freud, Sameek Roychowdhury, Katherine E. Walsh

https://doi.org/10.3324/haematol.2024.285146

May 23, 2024

Review Articles

Articles

Checkpoint inhibition enhances cell contacts between CD4+ T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma (244 Online Views)

Kübra Yadigaroglu, Sonja Scharf, Steffen Gretser, Hendrik Schäfer, Aresu Sadeghi Shoreh Deli, Andreas G. Loth, Hasmik Yegoryan, Roland Schmitz, Emmanuel Donnadieu, Martin-Leo Hansmann, Sylvia Hartmann

https://doi.org/10.3324/haematol.2023.284512

Use of defibrotide in COVID-19 pneumonia: comparison of a phase II study and a matched real-world cohort control (252 Online Views)

Annalisa Ruggeri, Francesco Corrado, Antonio Voza, Lee-Jen Wei, Gloria Catalano, Carmine Liberatore, Rosamaria Nitti, Carlo Fedeli, Alessandro Bruno, Eleonora Calabretta, Fabio Giglio, Fabio Sciutti, Francesca Lunghi, Giovanni Landoni, Alessio Aghemo, Massimo Iacobelli, Patrizia Rovere Querini, Paul G. Richardson, Andrea Assanelli, Jacopo Peccatori, Fabio Ciceri, Carmelo Carlo-Stella

https://doi.org/10.3324/haematol.2024.285345

Letters to the Editor

Combination low-intensity chemotherapy plus inotuzumab ozogamicin, blinatumomab and rituximab for pediatric patients with relapsed/refractory B-cell acute lymphoblastic leukemia (272 Online Views)

Amber Gibson, Cesar Nunez, Lindsay Robusto, Brianna Kammerer, Miriam Garcia, Michael Roth, Rachna Sheth, Priti Tewari, Aline Hittle, Laurie Toepfer, Romeo Torres, Nicholas J. Short, Elias Jabbour, Nitin Jain, Branko Cuglievan, David McCall

https://doi.org/10.3324/haematol.2023.284950

Clinical phenotype of adult-onset systemic histiocytosis harboring BRAF in-frame deletions (156 Online Views)

Matthias Papo, Jérôme Razanamahéry, Malik Da Silva, Zofia Hélias-Rodzewicz, Vsevolod Potapenko, Suzanna Bota, Vanessa Leguy-Seguin, Stéphane Dominique, Raphaël Lhote, Quentin Moyon, Dov Taïeb, Tom Abrassart, Marion Campana, Visal Keo, Etienne Rivière, Olivier Lucidarme, Fleur Cohen-Aubart, Zahir Amoura, Julien Haroche, Jean-François Emile

https://doi.org/10.3324/haematol.2024.285273

Simultaneous targeting of B-cell malignancies and human immunodeficiency virus with bispecific chimeric antigen receptor T cells (130 Online Views)

Ryan Urak, Saghar Pahlavanneshan, Brenna Gittins, Ryotaro Nakamura, John A. Zaia, John H. Baird, Mary C. Clark, Stephen J. Forman, Xiuli Wang

https://doi.org/10.3324/haematol.2024.285321

Comments

May 16, 2024

Editorials
Article

Cell-free DNA from nail clippings as source of normal control for genomic studies in hematologic malignancies (664 Online Views)

Melissa Krystel-Whittemore, Kseniya Petrova-Drus, Ryan N. Ptashkin, Mark D. Ewalt, JinJuan Yao, Ying Liu, Menglei Zhu, Jamal Benhamida, Benjamin Durham, Jyoti Kumar, Khedoudja Nafa, Iwona Kiecka, Anita S. Bowman, Erika Gedvilaite, Jacklyn Casanova, Yun-Te Lin, Abhinita S. Mohanty, Satshil Rana, Anoop Balakrishnan Rema, Ivelise Rijo, Nelio Chaves, Paulo Salazar, Anita Yun, Sean Lachhander, Wei Wang, Mohammad S. Haque, Wenbin Xiao, Mikhail Roshal, Sergio Giralt, Gilles Salles, Raajit Rampal, Eytan M. Stein, Miguel-Angel Perales, Steven Horwitz, Ann Jakubowski, Doris Ponce, Alina Markova, Ozge Birsoy, Diana Mandelker, Simon Mantha, Ahmet Dogan, Ryma Benayed, Marc Ladanyi, Michael F. Berger, A. Rose Brannon, Ahmet Zehir, Chad Vanderbilt, Maria E. Arcila

https://doi.org/10.3324/haematol.2024.285054

Editorials
Article

Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment (347 Online Views)

Sarah Liane Linguet, Suzanne Verlhac, Florence Missud, Laurent Holvoet-Vermaut, Valentine Brousse, Ghislaine Ithier, Alexandra Ntorkou, Emmanuelle Lesprit, Malika Benkerrou, Manoëlle Kossorotoff, Berengere Koehl

https://doi.org/10.3324/haematol.2023.283773

Editorials

Editorials
Letter to the Editor

Expedited evaluation of hereditary hematopoietic malignancies in the setting of stem cell transplantation (527 Online Views)

Gregory W. Roloff, Satyajit Kosuri, Mariam T. Nawas, Adam S. DuVall, Anand A. Patel, Peter A. Riedell, Olatoyosi Odenike, Wendy Stock, Richard A. Larson, Michael R. Bishop, Emma Nunley, Lucy A. Godley, Feighanne Hathaway, Daniela del Gaudio, Soma Das, Lorraine E. Canham, Michael W. Drazer

https://doi.org/10.3324/haematol.2023.284584

Letters to the Editor

Emapalumab as salvage therapy for adults with malignancy-associated hemophagocytic lymphohistiocytosis (307 Online Views)

William T. Johnson, Zachary D. Epstein-Peterson, Nivetha Ganesan, Timothy Pak, Tiffany Chang, Phuong Dao, Alison J. Moskowitz, Robert N. Stuver, Paola Ghione, Natasha Galasso, Niloufer Khan, M. Lia Palomba, Philip C. Caron, Anita Kumar, Roni Tamari, Jennifer K. Lue, Ariela Noy, Lorenzo Falchi, Andrew M. Intlekofer, Boglarka Gyurkocza, Miguel-Angel Perales, Michael Scordo, A. Zara Herskovits, Gilles Salles, Santosha A. Vardhana, Steven M. Horwitz

https://doi.org/10.3324/haematol.2023.284179

Comments

May 9, 2024

Editorials
Article

Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study (549 Online Views)

Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek

https://doi.org/10.3324/haematol.2023.284390

Editorials
Article

HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells (536 Online Views)

Tamara De Vos, Nicole Oatman, Lena Boehme, Tom Putteman, Imke Velghe, Yana Van Droogenbroeck, Stijn De Munter, Michaela Cesnekova, Filip Van Nieuwerburgh, Bart Vandekerckhove, Jan Philippe, Tom Taghon

https://doi.org/10.3324/haematol.2023.283432

Editorials
Article

Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia (658 Online Views)

Sarah A. Pötgens, Violaine Havelange, Sophie Lecop, Fuyong Li, Audrey M. Neyrinck, Florence Bindels, Nathalie Neveux, Jean-Baptiste Demoulin, Ine Moors, Tessa Kerre, Johan Maertens, Jens Walter, Hélène Schoemans, Nathalie M. Delzenne, Laure B. Bindels

https://doi.org/10.3324/haematol.2023.284138

Articles

Targeting CD19-positive lymphomas with the antibody-drug conjugate loncastuximab tesirine: preclinical evidence as single agent and in combination therapy (557 Online Views)

Chiara Tarantelli, David Wald, Nicolas Munz, Filippo Spriano, Alessio Bruscaggin, Eleonora Cannas, Luciano Cascione, Eugenio Gaudio, Alberto J. Arribas, Shivaprasad Manjappa, Gaetanina Golino, Lorenzo Scalise, Maria Teresa Cacciapuoti, Emanuele Zucca, Anastasios Stathis, Giorgio Inghirami, Patrick H. van Berkel, Davide Rossi, Paolo F. Caimi, Francesca Zammarchi, Francesco Bertoni

https://doi.org/10.3324/haematol.2023.284197

Anti-T-lymphocyte globulin exposure is associated with acute graft-versus-host disease and relapse in pediatric acute lymphoblastic leukemia patients undergoing hematopoietic stem cell transplantation: a multinational prospective study (506 Online Views)

Lisa V.E. Oostenbrink, Erik G.J. von Asmuth, Cornelia M. Jol-van der Zijde, Anja M. Jansen-Hoogendijk, Carly Vervat, Robbert G.M. Bredius, Maarten J.D. van Tol, Marco W. Schilham, Petr Sedlacek, Marianne Ifversen, Adriana Balduzzi, Peter Bader, Christina Peters, Dirk Jan A.R. Moes, Arjan C. Lankester

https://doi.org/10.3324/haematol.2023.284632

The diversity of the microbiome impacts chronic lymphocytic leukemia development in mice and humans (348 Online Views)

Tereza Faitova, Mariana Coelho, Caspar da Cunha-Bang, Selcen Ozturk, Ece Kartal, Peer Bork, Martina Seiffert, Carsten U. Niemann

https://doi.org/10.3324/haematol.2023.284693

Continuous and differential improvement in worldwide access to hematopoietic cell transplantation: activity has doubled in a decade with a notable increase in unrelated and non-identical related donors (479 Online Views)

Yoshiko Atsuta, Helen Baldomero, Daniel Neumann, Anna Sureda, Jakob D. DeVos, Minako Iida, Amado Karduss, Duncan Purtill, Alaa M. Elhaddad, Nosa G. Bazuaye, Carmem Bonfim, Rafael de la Camara, Naeem A. Chaudhri, Fabio Ciceri, Cinthya Correa, Cristobal Frutos, Sebastian Galeano, Laurent Garderet, Oscar Gonzalez-Ramella, Raffaella Greco, Nada Hamad, Mette D. Hazenberg, Mary M. Horowitz, Krzysztof Kalwak, Bor-Sheng Ko, Yoshihisa Kodera, Mickey BC Koh, Kaiyan Liu, Donal P. McLornan, Joon Ho Moon, Benedicte Neven, Shinichiro Okamoto, Marcelo C Pasquini, Jakob R. Passweg, Kristjan Paulson, Damiano Rondelli, Annalisa Ruggeri, Adriana Seber, John A. Snowden, Alok Srivastava, Jeff Szer, Daniel Weisdorf, Nina Worel, Hildegard Greinix, Wael Saber, Mahmoud Aljurf, Dietger Niederwieser

https://doi.org/10.3324/haematol.2024.285002

Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 Protocol (342 Online Views)

Bernward Zeller, Nira Arad-Cohen, Daniel Cheuk, Barbara De Moerloose, Jose M. Fernandez Navarro, Henrik Hasle, Kirsi Jahnukainen, Kristian Lovvik Juul-Dam, Gertjan Kaspers, Zanna Kovalova, Olafur G. Jonsson, Birgitte Lausen, Monica Munthe-Kaas, Ulrika Noren Nystrom, Josefine Palle, Ramune Pasauliene, Cornelis J. Pronk, Kadri Saks, Anne Tierens, Jonas Abrahamsson

https://doi.org/10.3324/haematol.2024.285285

Letters to the Editor

A rescue approach in refractory diffuse large B-cell lymphoma with obinutuzumab-redirected cytokine-induced killer cells: a first-in-human case report (360 Online Views)

Francesca Elice, Roberta Sommaggio, Elisa Cappuzzello, Marcello Riva, Maria Chiara Tisi, Martina Bernardi, Angela Bozza, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Ilaria Giaretta, Anna Dalla Pieta, Mauro Krampera, Carlo Visco, Livio Trentin, Andrea Visentin, Alberto Tosetto, Giuseppe Astori, Antonio Rosato

https://doi.org/10.3324/haematol.2023.284881

The insertion/deletion polymorphism rs201494641 at ITGA9 influences blood CD34+ cell levels by altering ZNF384 binding (172 Online Views)

Caterina Cafaro, Zain Ali, Antton Lamarca, Daniela Torres Di Bello, Laura Duran Lozano, Ludvig Ekdahl, Malte Thodberg, Maroulio Pertesi, Aitzkoa Lopez de Lapuente Portilla, Björn Nilsson

https://doi.org/10.3324/haematol.2024.285363

Case Reports

A case of familial donor-derived acute myeloid leukemia with underlying pre-leukemic mutations (198 Online Views)

Luca Vincenzo Cappelli, Clara Minotti, Manja Meggendorfer, Marietta Truger, Torsten Haferlach, Cristina Mecucci, Caterina Matteucci, Caterina Alati, Anna Paola Iori, Maurizio Martelli, Robin Foà

https://doi.org/10.3324/haematol.2024.285156

May 2, 2024

Editorials

Articles

Treatment of chronic-phase chronic myeloid leukemia in patients randomized to dasatinib or imatinib after suboptimal responses to three months of imatinib therapy: final 5-year results from DASCERN (518 Online Views)

Jorge E. Cortes, Qian Jiang, Jianxiang Wang, Jianyu Weng, Huanling Zhu, Xiaoli Liu, Andreas Hochhaus, Dong-Wook Kim, Jerald Radich, Michael Savona, Patricia Martin-Regueira, Oumar Sy, Giuseppe Saglio

https://doi.org/10.3324/haematol.2023.283428

The initial molecular response predicts the deep molecular response but not treatment-free remission maintenance in a real-world chronic myeloid leukemia cohort (357 Online Views)

Sandrine Saugues, Céline Lambert, Elisabeth Daguenet, Gabrielle Roth-Guepin, Françoise Huguet, Pascale Cony-Makhoul, Hyacinthe Johnson Ansah, Martine Escoffre-Barbe, Ali Turhan, Philippe Rousselot, Andreï Tchirkov, Dalil Hamroun, Eric Hermet, Bruno Pereira, Marc G. Berger

https://doi.org/10.3324/haematol.2023.284860

Outcomes and genetic dynamics of acute myeloid leukemia at first relapse (925 Online Views)

Alex Bataller, Hagop Kantarjian, Alexandre Bazinet, Tapan Kadia, Naval Daver, Courtney D. DiNardo, Gautam Borthakur, Sanam Loghavi, Keyur Patel, Guilin Tang, Koji Sasaki, Nicholas J. Short, Musa Yilmaz, Ghayas C. Issa, Yesid Alvarado, Guillermo Montalban-Bravo, Abhishek Maiti, Hussein A. Abbas, Koichi Takahashi, Sherry Pierce, Elias Jabbour, Guillermo Garcia-Manero, Farhad Ravandi

https://doi.org/10.3324/haematol.2024.285057

Letters to the Editor

CD22-targeted glyco-engineered natural killer cells offer a further treatment option for B-cell acute lymphoblastic leukemia (239 Online Views)

Xin Jin, Rui Sun, Zhu Li, Xianwu Wang, Xia Xiong, Wenyi Lu, Hairong Lyu, Xia Xiao, Yunpeng Tian, Hongkai Zhang, Zhihong Fang, Luqiao Wang, Mingfeng Zhao

https://doi.org/10.3324/haematol.2023.284241

Soluble urokinase plasminogen activator receptor is associated with kidney disease and its progression in sickle cell anemia (235 Online Views)

Rima S. Zahr, Sara R. Rashkin, Maria Armila Ruiz, Laila Elsherif, Guohui Ren, Guadalupe Salas, Kenneth I. Ataga, Victor R. Gordeuk, Jeffrey Lebensburger, Xu Zhang, Santosh L. Saraf

https://doi.org/10.3324/haematol.2023.284920

Comments

Apr 24, 2024

Editorials
Article

Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing (427 Online Views)

Haley Newman, Mary Egan Clark, Derek Wong, Jinhua Wu, Garrett M Brodeur, Stephen P Hunger, Sarah K Tasian, Timothy Olson, Julia T. Warren, David T Teachey, Kira Bona, Jeffrey Schubert, Netta Golenberg, Maha Patel, Elizabeth H Denenberg, Elizabeth A Fanning, Jiani Chen, Tamara Luke, Sarah Charles, Daniel Gallo, Kajia Cao, Weixuan Fu, Zhiqian Fan, Lea F Surrey, Gerald Wertheim, Minjie Luo, Suzanne P MacFarland, Marilyn M Li, Yiming Zhong

https://doi.org/10.3324/haematol.2023.284855

Editorials
Article

Impact and utility of follicular lymphoma GELF criteria in routine care: an Australasian Lymphoma Alliance study (514 Online Views)

Allison Barraclough, Shivam Agrawal, Dipti Talaulikar, Geoffrey Chong, Edward Yoo, Chan Y. Cheah, Nunzio Franco, Bianca Nguyen, Howard Mutsando, Fatima Tahir, Judith Trotman, Jing Huang, Colm Keane, Mitchel Lincoln, Tara Cochrane, Anna M. Johnston, Michael Dickinson, Stephen Opat, Zoe K. McQuilten, Erica M. Wood, Gayathri St George, Eliza A. Hawkes

https://doi.org/10.3324/haematol.2023.284538

Editorials

Articles

Monocyte response to SARS-CoV-2 protein ORF8 is associated with severe COVID-19 infection in patients with chronic lymphocytic leukemia (265 Online Views)

Gordon J. Ruan, Xiaosheng Wu, Kimberly A. Gwin, Michelle K Manske, Jithma P. Abeykoon, Vaishali Bhardwaj, Taylor L. Witter, Matthew J. Schellenberg, Kari G Rabe, Neil E. Kay, Sameer A. Parikh, Thomas E. Witzig

https://doi.org/10.3324/haematol.2023.284617

Time from diagnosis to treatment has no impact on survival in newly diagnosed acute myeloid leukemia treated with venetoclax-based regimens (506 Online Views)

David Baden, Sven Zukunft, Gema Hernandez, Nadine Wolgast, Sophie Steinhauser, Alexander Pohlmann, Christoph Schliemann, Jan-Henrik Mikesch, Bjorn Steffen, Tim Sauer, Maher Hanoun, Kerstin Schafer-Eckart, Stefan W. Krause, Mathias Hanel, Hermann Einsele, Edgar Jost, Tim H. Brummendorf, Sebastian Scholl, Andreas Hochhaus, Andreas Neubauer, Andreas Burchert, Martin Kaufmann, Dirk Niemann, Markus Schaich, Wolfgang Blau, Alexander Kiani, Martin Gorner, Ulrich Kaiser, Johannes Kullmer, Thomas Weber, Wolfgang E Berdel, Gerhard Ehninger, Carsten Muller-Tidow, Uwe Platzbecker, Hubert Serve, Martin Bornhauser, Christoph Rollig, Claudia D Baldus, Lars Fransecky

https://doi.org/10.3324/haematol.2024.285225

Letters to the Editor

Differential activation of basal and IL-7-induced PI3K/Akt/mTOR and JAK/STAT5 signaling distinguishes pediatric from adult acute lymphoblastic leukemia (258 Online Views)

Marta B. Fernandes, A. Margarida Gomes, Mariana L. Oliveira, Joana Caldas, Paulo Lúcio, Rathana Kim, Aurélie Caye-Eude, Filomena Pereira, Aida B. de Sousa, Alessia De Stefano, Matilde Y. Follo, Maria V. Soares, João F. Lacerda, Joana Desterro, Hélène Cavé, Emmanuelle Clappier, Ximo Duarte, Patrícia Ribeiro, João T. Barata

https://doi.org/10.3324/haematol.2023.284102

Apr 18, 2024

Editorials
Letter to the Editor

TP53 DNA binding domain mutational status and rituximab-based treatment are independent prognostic factors for pediatric Burkitt lymphoma patients stratification (394 Online Views)

Gaia Martire, Federica Lovisa, Elisa Carraro, Domenico Rizzato, Simone Cesaro, Rosa Maria Mura, Annalisa Tondo, Cinzia Bertolin, Francesca Boaretto, Leonardo Salviati, Alessandra Biffi, Marta Pillon, Lara Mussolin

https://doi.org/10.3324/haematol.2023.284868

Editorials
Article

Small extracellular vesicles derived from acute myeloid leukemia cells promote leukemogenesis by transferring miR-221-3p (708 Online Views)

Mengyu Li, Guohuan Sun, Jinlian Zhao, Shuangshuang Pu, Yanling Lv, Yifei Wang, Yapu Li, Xiangnan Zhao, Yajie Wang, Shangda Yang, Tao Cheng, Hui Cheng

https://doi.org/10.3324/haematol.2023.284145

Editorials
Letter to the Editor

Systemic diffuse large B-cell lymphoma involving the central nervous system have high rates of defective antigen presentation and immune surveillance (657 Online Views)

Joel Wight, Piers Blombery, Jennifer Lickiss, Melinda Burgess, Clare Gould, Adrian Minson, Fiona Swain, Muhammed B. Sabdia, Maher K. Gandhi, Andrew Birchley, Colm Keane, Eliza A Hawkes

https://doi.org/10.3324/haematol.2023.284600

Editorials
Article

Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease (613 Online Views)

Angelo D’Alessandro, Kang Le, Maureen Lundt, Quan Li, Emily B. Dunkelberger, Troy Cellmer, Andrew J. Worth, Spurthi Patil, Chris Huston, Abby Grier, Monika Dzieciatkowska, Daniel Stephenson, William A. Eaton, Swee Lay Thein

https://doi.org/10.3324/haematol.2023.284831

Letters to the Editor

Validation of mutated CEBPA bZIP as a distinct prognosis entity in acute myeloid leukemia: a study by the Spanish PETHEMA registry (341 Online Views)

Esther Prados de la Torre, Josefina Serrano, David Martínez-Cuadrón, Laura Torres, Claudia Sargas, Rosa Ayala, Cristina Bilbao-Sieyro, María Carmen Chillón, María José Larráyoz, Elena Soria, Clara Aparicio-Pérez, Juan M. Bergua, Teresa Bernal, Cristina Gil, Mar Tormo, Lorenzo Algarra, Juan M. Alonso-Domínguez, Eduardo Rodriguez-Arbolí, Pilar Martínez-Sanchez, Ana Oliva, Ana M. Colorado-Araujo, Carlos Rodríguez-Medina, Susana Vives, Lourdes Hermosín, Joaquín Martínez-López, Ramón García-Sanz, José A. Pérez-Simón, María José Calasanz, María Teresa Gómez-Casares, Eva Barragán, Joaquín Sánchez-García J, Pau Montesinos

https://doi.org/10.3324/haematol.2023.284601

IRF4-BLOC1S5: the first rearrangement gene identified in TEMPI syndrome (272 Online Views)

Ming Zhao, Jia Liu, Qing Yu, Wenbin Xu, Zilu Zhang, Ze Fu, Mingyuan Jia, Xinyi Zeng, Chengyu Wu, Chenjing Ye, Chao Wu, Yingli Wu, Ruibao Ren, Junmin Li, Kankan Wang, Hua Yan

https://doi.org/10.3324/haematol.2023.284727

Outcome of infants with acute lymphoblastic leukemia treated with the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia 2015 study protocol (357 Online Views)

Alex WK Leung, Jiaoyang Cai, Zhi Wan, Jiefen Qin, Yongjun Fang, Lirong Sun, Jiashi Zhu, Shaoyan Hu, Ningling Wang, Pan Gao, Xin Tian, Xiaofan Zhu, Fen Zhou, Xuedong Wu, Xiuli Ju, Xiaowen Zhai, Hua Jiang, Qun Hu, Changda Liang, Liangchun Yang, Hui Zhang, Jingyan Tang, Ju Gao, Ching-Hon Pui, Chi-kong Li

https://doi.org/10.3324/haematol.2024.285201

Hypomethylating agents are associated with high rates of hematologic toxicity in patients with secondary myeloid neoplasms developing after acquired aplastic anemia (345 Online Views)

Matthew P. Connor, Neeharika Prathapa, Noelle V. Frey, Saar I. Gill, Elizabeth O. Hexner, Ximena Jordan Bruno, Catherine E. Lai, Alison W. Loren, Selina M. Luger, Andrew H. Matthews, Shannon R. McCurdy, Alexander E Perl, David L. Porter, Arlene Zeringue, Joseph H. Oved, Timothy S. Olson, Keith W. Pratz, Daria V. Babushok

https://doi.org/10.3324/haematol.2024.285275

Apr 11, 2024

Editorial
Article

Enhancement of PRMT6 binding to a novel germline GATA1 mutation associated with congenital anemia (531 Online Views)

Yingsi Lu, Qingqing Zhu, Yun Wang, Meiling Luo, Junbin Huang, Qian Liang, Lifen Huang, Jing Ouyang, Chenxin Li, Nannan Tang, Yan Li, Tingting Kang, Yujia Song, Xiaoyu Xu, Liping Ye, Guoxing Zheng, Chun Chen, Chengming Zhu

https://doi.org/10.3324/haematol.2023.284183

Editorial
Article

Germline bi-allelic SH2B3/LNK alteration predisposes to a neonatal juvenile myelomonocytic leukemia-like disorder (773 Online Views)

Chloé Arfeuille, Yoann Vial, Margaux Cadenet, Aurélie Caye-Eude, Odile Fenneteau, Quentin Neven, Adeline A Bonnard, Simone Pizzi, Giovanna Carpentieri, Yline Capri, Katia Girardi, Lucia Pedace, Marina Macchiaiolo, Kamel Boudhar, Monia ben Khaled, Wadih Abou Chahla, Anne Lutun, Mony Fahd, Séverine Drunat, Elisabetta Flex, Jean-Hugues Dalle, Marion Strullu, Franco Locatelli, Marco Tartaglia, Hélène Cavé

https://doi.org/10.3324/haematol.2023.283917
Article

LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia (953 Online Views)

Astrid Wintering, Anna Hecht, Julia Meyer, Eric B. Wong, Juwita Hübner, Sydney Abelson, Kira Feldman, Vanessa E. Kennedy, Cheryl A.C. Peretz, Deborah L. French, Jean Ann Maguire, Chintan Jobaliya, Marta Rojas Vasquez, Sunil Desai, Robin Dulman, Eneida Nemecek, Hilary Haines, Mahmoud Hammad, Alaa El Haddad, Scott C. Kogan, Zied Abdullaev, Farid F. Chehab, Sarah K. Tasian, Catherine C. Smith, Mignon L. Loh, Elliot Stieglitz

https://doi.org/10.3324/haematol.2023.283776

Review Articles

Articles

Letters to the Editor

Expedited evaluation of hereditary hematopoietic malignancies in the setting of stem cell transplantation (527 Online Views)

Gregory W. Roloff, Satyajit Kosuri, Mariam T. Nawas, Adam S. DuVall, Anand A. Patel, Peter A. Riedell, Olatoyosi Odenike, Wendy Stock, Richard A. Larson, Michael R. Bishop, Emma Nunley, Lucy A. Godley, Feighanne Hathaway, Daniela del Gaudio, Soma Das, Lorraine E. Canham, Michael W. Drazer

https://doi.org/10.3324/haematol.2023.284584

Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes (517 Online Views)

Agata Gruszczynska, Abhishek Maiti, Christopher A. Miller, Sai Mukund Ramakrishnan, Daniel C. Link, Geoffrey L. Uy, Allegra A. Petti, Kala Hayes, Courtney D. DiNardo, Farhad Ravandi, Timothy J. Ley, David H. Spencer, Feng Gao, Marina Y. Konopleva, John S. Welch

https://doi.org/10.3324/haematol.2022.281396

Apr 4, 2024

Editorials
Article

ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression (786 Online Views)

Wenqian Xu, Feng Tian, Xiaolu Tai, Gaoxian Song, Yuanfang Liu, Liquan Fan, Xiangqin Weng, Eunjeong Yang, Meng Wang, Martin Bornhäuser, Chao Zhang, Richard B. Lock, Jason W.H. Wong, Jin Wang, Duohui Jing, Jian-Qing Mi

https://doi.org/10.3324/haematol.2023.284121

Articles

CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia (571 Online Views)

Chi Zhang, Kathy Yuen Yee Chan, Wing Hei Ng, John Tak Kit Cheung, Qiwei Sun, Han Wang, Po Yee Chung, Frankie Wai Tsoi Cheng, Alex Wing Kwan Leung, Xiao-Bing Zhang, Po Yi Lee, Siu Ping Fok, Guanglan Lin, Ellen Ngar Yun Poon, Jian-Hua Feng, Yan-Lai Tang, Xue-Qun Luo, Li-Bin Huang, Wei Kang, Patrick Ming Kuen Tang, Junbin Huang, Chun Chen, Junchao Dong, Ester Mejstrikova, Jiaoyang Cai, Yu Liu, Shuhong Shen, Jun J Yang, Patrick Man Pan Yuen, Chi Kong Li, Kam Tong Leung

https://doi.org/10.3324/haematol.2023.282952

HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells (536 Online Views)

Tamara De Vos, Nicole Oatman, Lena Boehme, Tom Putteman, Imke Velghe, Yana Van Droogenbroeck, Stijn De Munter, Michaela Cesnekova, Filip Van Nieuwerburgh, Bart Vandekerckhove, Jan Philippe, Tom Taghon

https://doi.org/10.3324/haematol.2023.283432

Hematopoiesis post anti-CD117 monoclonal antibody treatment in wild-type and Fanconi anemia settings (502 Online Views)

Morgane Denis, Leah Swartzrock, Hana Willner, Quenton R. Bubb, Ethan Haslett, Yan Yi Chan, Anzhi Chen, Mark R. Krampf, Agnieszka D. Czechowicz

https://doi.org/10.3324/haematol.2023.284275

Endurance training improves oxygen uptake/demand mismatch, metabolic flexibility and recovery in patients with sickle cell disease (339 Online Views)

Loïs Mougin, Manon Riccetti, Angèle N. Merlet, Pablo Bartolucci, Barnabas Gellen, Léo Blervaque, Thomas d’Humières, Frédéric Galactéros, Chi-An W. Emhoff, Léonard Féasson, Laurent A. Messonnier

https://doi.org/10.3324/haematol.2023.284474

Mutual regulation of CD4+ T cells and intravascular fibrin in infections (607 Online Views)

Tonina T. Mueller, Mona Pilartz, Manovriti Thakur, Torben LangHeinrich, Junfu Luo, Rebecca Block, Jonathan K.L. Hoeflinger, Sarah Meister, Flavio Karaj, Laura Garcia Perez, Rupert Öllinger, Thomas Engleitner, Jakob Thoss, Michael Voelkl, Claudia Tersteeg, Uwe Koedel, Alexander Zigman Kohlmaier, Daniel Teupser, Malgorzata Wygrecka, Haifeng Ye, Klaus T. Preissner, Helena Radbruch, Sefer Elezkurtaj, Matthias Mack, Philipp von Hundelshausen, Christian Weber, Steffen Massberg, Christian Schulz, Roland Rad, Samuel Huber, Hellen Ishikawa-Ankerhold, Bernd Engelmann

https://doi.org/10.3324/haematol.2023.284619

A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia (585 Online Views)

Guru Subramanian Guru Murthy, Antoine N. Saliba, Aniko Szabo, Alexandra Harrington, Sameem Abedin, Karen Carlson, Laura Michaelis, Lyndsey Runaas, Arielle Baim, Alex Hinman, Sonia Maldonado-Schmidt, Annapoorna Venkatachalam, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Mark Litzow, Scott H. Kaufmann, Ehab Atallah

https://doi.org/10.3324/haematol.2024.285014

Soluble B-cell maturation antigen in lacrimal fluid as a potential biomarker and mediator of keratopathy in multiple myeloma (735 Online Views)

Umair Munawar, Johanna Theuersbacher, Maximilian J. Steinhardt, Xiang Zhou, Seungbin Han, Silvia Nerreter, Cornelia Vogt, Shilpa Kurian, Thorsten Keller, Ann-Katrin Regensburger, Eva Teufel, Julia Mersi, Max Bittrich, Franziska Seifert, Malik S. Haider, Leo Rasche, Jost Hillenkamp, Hermann Einsele, Daniel Kampik, K. Martin Kortüm, Johannes M. Waldschmidt

https://doi.org/10.3324/haematol.2024.285205

Letters to the Editor

Sotatercept for anemia of myelofibrosis: a phase II investigator-initiated study (772 Online Views)

Prithviraj Bose, Lucia Masarova, Naveen Pemmaraju, Sharon D. Bledsoe, Naval G. Daver, Elias J. Jabbour, Tapan M. Kadia, Zeev Estrov, Steven M. Kornblau, Michael Andreeff, Nitin Jain, Jorge E. Cortes, Gautam Borthakur, Yesid Alvarado, Mary Ann Richie, Mackenzie H. Dobbins, Selene A. McCrackin, Lingsha Zhou, Sherry A. Pierce, Xuemei Wang, Allison M. Pike, Guillermo Garcia-Manero, Hagop M. Kantarjian, Srdan Verstovsek

https://doi.org/10.3324/haematol.2023.284078

Dexamethasone treatment for COVID-19 is related to increased mortality in hematologic malignancy patients: results from the EPICOVIDEHA Registry (1259 Online Views)

Tommaso Francesco Aiello, Jon Salmanton-Garcia, Francesco Marchesi, Barbora Weinbergerova, Andreas Glenthoj, Jens Van Praet, Francesca Farina, Julio Davila-Valls, Sonia Martin-Perez, Shaimaa El-Ashwah, Martin Schonlein, Iker Falces-Romero, Jorge Labrador, Uluhan Sili, Caterina Buquicchio, Antonio Vena, Gaetan Plantefeve, Verena Petzer, Monika M. Biernat, Tobias Lahmer, Ildefonso Espigado, Jaap Van Doesum, Ola Blennow, Klara Piukovics, Carlo Tascini, Michail Samarkos, Yavuz M. Bilgin, Luana Fianchi, Federico Itri, Toni Valković, Nicola S. Fracchiolla, Michelina Dargenio, Moraima Jimenez, Ferenc Magyari, Alberto Lopez-Garcia, Lucia Prezioso, Natasha Čolović, Evgenii Shumilov, Ghaith Abu-Zeinah, Carolin Krekeler, Esperanza Lavilla-Rubira, Mario Virgilio Papa, Tomas Jose Gonzalez-Lopez, Laszlo Imre Pinczes, Fatih Demirkan, Natasha Ali, Caroline Besson, Guillemette Fouquet, Alessandra Romano, Jose-Angel Hernandez-Rivas, Maria Ilaria Del Principe, Avinash Aujayeb, Maria Merelli, Sylvain Lamure, Joyce Marques De Almeida, Maria Gomes Da Silva, Noha Eisa, Joseph Meletiadis, Ikhwan Rinaldi, Olimpia Finizio, Ozren Jaksic, Mario Delia, Summiya Nizamuddin, Monia Marchetti, Marriyam Ijaz, Marina Machado, Rebeca Bailen-Almorox, Martin Čerňan, Nicola Coppola, Eleni Gavriilaki, Chiara Cattaneo, Ana Groh, Zlate Stojanoski, Nurettin Erben, Nicola Pantic, Gustavo-Adolfo Mendez, Roberta Di Blasi, Stef Meers, Cristina De Ramon, Nathan C. Bahr, Ziad Emarah, Gina Varricchio, Milche Cvetanoski, Ramon Garcia-Sanz, Mirjana Mitrovic, Raphael Lievin, Michaela Hanakova, Zdeněk Račil, Maria Vehreschild, Athanasios Tragiannidis, Raquel Nunes Rodrigues, Daniel Garcia-Bordallo, Raul Cordoba, Alba Cabirta, Anna Nordlander, Emanuele Ammatuna, Elena Arellano, Dominik Wolf, Romane Prin, Alessandro Limongelli, Martina Bavastro, Gokce Melis Colak, Stefanie Grafe, Ditte Stampe Hersby, Laman Rahimli, Oliver A. Cornely, Carolina Garcia-Vidal, Livio Pagano; EPICOVIDEHA study group (Collaborative Group)

https://doi.org/10.3324/haematol.2023.284678

Outcomes after chimeric antigen receptor T-cell therapy across large B-cell lymphoma subtypes (398 Online Views)

Christianne Bourlon, Claire Roddie, Tobias Menne, Jane Norman, Maeve O’Reilly, Adam Gibb, Caroline Besley, Sridhar Chaganti, Carlos Gonzalez Arias, Ceri Jones, Abdalla Dikair, Sharon Allen, Frances Seymour, Wendy Osborne, Amrith Mathew, William Townsend, Piers EM Patten, Eleni Thoulouli, Ahmed Abdulgawad, Sanne Lugthart, Robin Sanderson, Amy A Kirkwood, Andrea Kuhnl

https://doi.org/10.3324/haematol.2024.285010

Universal germline genetic testing in patients with hematologic malignancies using DNA isolated from nail clippings (324 Online Views)

Ozge Ceyhan-Birsoy, Elise Fiala, Satshil Rana, Margaret Sheehan, Jennifer Kennedy, Zarina Yelskaya, Vikas Rai, Yirong Li, Ciyu Yang, Donna Wong, Ivelise Rijo, Jacklyn Casanova, Joshua Somar, Nikita Mehta, Hyeonjin Park, Silvana Ostafi, Kanika Arora, Angelika Padunan, Mark D. Ewalt, Umut Aypar, Panieh Terraf, Maksym Misyura, Sofia Haque, Gerald G. Behr, Tamanna Haque, Maria Sulis, Mark B. Geyer, Christopher Forlenza, Meghan C. Thompson, Maria Carlo, Alicia Latham, Ying Liu, Ahmet Zehir, Rose Brannon, Michael Berger, Luis A Diaz Jr, Ahmet Dogan, Marc Ladanyi, Kseniya Petrova-Drus, Khedoudja Nafa, Kenneth Offit, Maria Arcila, Zsofia K. Stadler, Michael F. Walsh, Diana Mandelker

https://doi.org/10.3324/haematol.2024.285055

Mar 28, 2024

Editorials
Article

IELSG38: phase II trial of front-line chlorambucil plus subcutaneous rituximab induction and maintenance in mucosa-associated lymphoid tissue lymphoma (687 Online Views)

Anastasios Stathis, Maria Cristina Pirosa, Lorella Orsucci, Pierre Feugier, Monica Tani, Hervé Ghesquières, Gerardo Musuraca, Francesca Gaia Rossi, Francesco Merli, Romain Guièze, Emmanuel Gyan, Guido Gini, Dario Marino, Remy Gressin, Franck Morschhauser, Federica Cavallo, Francesca Palombi, Annarita Conconi, Benoît Tessoulin, Hervé Tilly, Manuela Zanni, Maria Giuseppina Cabras, Enrico Capochiani, Catello Califano, Melania Celli, Alessandro Pulsoni, Francesco Angrilli, Ubaldo Occhini, René-Olivier Casasnovas, Guillaume Cartron, Liliana Devizzi, Corinne Haioun, Anna Marina Liberati, Roch Houot, Michele Merli, Giuseppe Pietrantuono, Francesca Re, Michele Spina, Francesco Landi, Franco Cavalli, Francesco Bertoni, Davide Rossi, Nicoletta Ielmini, Elena Borgo, Stefano Luminari, Emanuele Zucca, Catherine Thieblemont

https://doi.org/10.3324/haematol.2023.283918

Editorials
Article

A Japanese retrospective study of non-tuberculous mycobacterial infection in children, adolescents, and young adult patients with hematologic-oncologic diseases (717 Online Views)

Yusuke Tsumura, Hideki Muramatsu, Nobuyuki Tetsuka, Takahiro Imaizumi, Kikue Sato, Kento Inoue, Yoshitomo Motomura, Yuko Cho, Daiki Yamashita, Daichi Sajiki, Ryo Maemura, Ayako Yamamori, Masayuki Imaya, Manabu Wakamatsu, Kotaro Narita, Shinsuke Kataoka, Motoharu Hamada, Rieko Taniguchi, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Yoshihiko Hoshino, Yoshiyuki Takahashi

https://doi.org/10.3324/haematol.2023.283636

Articles

Tocilizumab administration in cytokine release syndrome is associated with hypofibrinogenemia after chimeric antigen receptor T-cell therapy for hematologic malignancies (603 Online Views)

Markus Perl, Konstantin Herfeld, Dennis C. Harrer, Matthias Höpting, Marina Schweiger, Ulrich Sterz, Leonard Knödler, Susanne Heimerl, Leo Hansmann, Wolfgang Herr, Hendrik Poeck, Daniel Wolff, Matthias Edinger, Christina Hart, Matthias A. Fante

https://doi.org/10.3324/haematol.2023.284564

Long-term outcomes and renal responses following autologous hematopoietic stem cell transplantation for light chain deposition disease: a retrospective study on behalf of the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation (313 Online Views)

Laurent Garderet, Luuk Gras, Linda Koster, Liesbeth de Wreede, Rovira Montserrat, Laure Vincent, Roland Fenk, Kamaraj Karunanithi, Dries Deeren, Martin Kaufmann, Jürgen Kuball, Hakan Ozdogu, Maria Jesus Pascual Cascon, Jakob Passweg, Adam Rye, Urpu Salmenniemi, John Snowden, Charlotte Toftmann Hansen, Xavier Leleu, Lauris Gastaud, Joanna Drozd Sokolowska, Kavita Raj, Meral Beksac, Stefan Schönland, Patrick Hayden, Donal McLornan

https://doi.org/10.3324/haematol.2023.284520

Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia (658 Online Views)

Sarah A. Pötgens, Violaine Havelange, Sophie Lecop, Fuyong Li, Audrey M. Neyrinck, Florence Bindels, Nathalie Neveux, Jean-Baptiste Demoulin, Ine Moors, Tessa Kerre, Johan Maertens, Jens Walter, Hélène Schoemans, Nathalie M. Delzenne, Laure B. Bindels

https://doi.org/10.3324/haematol.2023.284138

MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications (441 Online Views)

Chengfeng Bi, Yuhua Huang, Roshia Ali, Fang Wang, Xia Yang, Alyssa Bouska, Lu Xu, Xinbao Hao, Matthew A. Lunning, Wing C. Chan, Javeed Iqbal, Dennis D. Weisenburger, Julie M. Vose, Kai Fu

https://doi.org/10.3324/haematol.2023.283811

Letters to the Editor

Elderly long-term survivors in the Nordic phase II study with first-line maintenance temozolomide for primary central nervous system lymphoma: a 10-year follow-up (318 Online Views)

Elisa Jacobsen Pulczynski, Mikkel Runason Simonsen, Outi Kuittinen, Unn-Merete Fagerli, Martin Erlanson, Øystein Fluge, Sirpa Leppä, Bjørn Østenstad, Alexander Fosså, Mikael Eriksson, Tarec El-Galaly, Hanne Kuitunen, Karin Papworth, Maria Ljungqvist, Martin B. Pedersen, Marjukka Pollari

https://doi.org/10.3324/haematol.2024.285207

Non-myeloma light chain cast nephropathy: a multicenter retrospective study on clinicopathological characteristics (274 Online Views)

Ana Cristina Martins, Jean-Baptiste Gibier, Charles Ronsin, Christine Kandel-Aznar, Anne Moreau, Marion Chapal, Diogo Francisco, Hamza Sakhi, Julie Oniszczuk, Lorraine Gueguen, Anne Grunenwald, Mathilde Devaux, Alexandre Karras, Virginie Royal, Marion Rabant, Viviane Gnemmi, Jérôme Olagne, Jean-Paul Duong Van Huyen, Pierre Isnard

https://doi.org/10.3324/haematol.2024.285031

High annualized bleeding rates in pediatric patients with inherited platelet function disorders (237 Online Views)

Shelly Saini, Song Zhang, Sean Yates, Jessica Garcia, Ruchika Sharma, Joseph Formella, Ravindra Sarode, Ayesha Zia

https://doi.org/10.3324/haematol.2024.284996

Acute myeloid leukemia with mast cell differentiation is characterized by interstitial mast cells, complex karyotype, TP53 alterations and poor prognosis (303 Online Views)

Do Hwan Kim, Sa A. Wang, Wei Wang, Guilin Tang, Shaoying Li, C. Cameron Yin, Pei Lin, Marina Konopleva, M. James You, Roberto N. Miranda, Xiaoqiong Wang, Qing Wei, L. Jeffrey Medeiros, Jie Xu

https://doi.org/10.3324/haematol.2024.284976

Cladribine plus cytarabine plus venetoclax in acute myeloid leukemia relapsed or refractory to venetoclax plus hypomethylating agent (906 Online Views)

Nickolas Steinauer, Kristen McCullough, Aref Al-Kali, Hassan B. Alkhateeb, Kebede H. Begna, Abhishek A. Mangaonkar, Antoine N. Saliba, Mehrdad Torghabeh, Mark R. Litzow, William J. Hogan, Mithun Shah, Mrinal M. Patnaik, Animesh Pardanani, Talha Badar, Hemant Murthy, James Foran, Cecilia Arana Yi, Ayalew Tefferi, Naseema Gangat

https://doi.org/10.3324/haematol.2024.284962

Case Reports

BCMA x CD3 T-cell engager in a patient with penta-refractory multiple myeloma and HIV: a clinical and immunological report (383 Online Views)

Leon Cords, Christoph Schaefers, Abdulaziz Kamili, Christian Hoffmann, Sophia Cichutek, Friedrich Haag, Susanne Polywka, Carsten Bokemeyer, Lisa Leypoldt, Winfried Alsdorf, Julian Schulze zur Wiesch, Katja C. Weisel

https://doi.org/10.3324/haematol.2023.284917

Mar 21, 2024

Editorials
Article

B-cell precursor acute lymphoblastic leukemia elicits an interferon-α/β response in bone marrow-derived mesenchymal stroma (421 Online Views)

Mandy W. E. Smeets, Elisabeth M. P. Steeghs, Jan Orsel, Femke Stalpers, Myrthe M. P. Vermeeren, Christina H. J. Veltman, Lotte Slenders, Stefan Nierkens, Cesca van de Ven, Monique L. den Boer

https://doi.org/10.3324/haematol.2023.283494

Articles

Steroid-free combination of 5-azacytidine and venetoclax for the treatment of multiple myeloma (1345 Online Views)

Lyndsey Flanagan, Aisling Coughlan, Nicola Cosgrove, Andrew Roe, Yu Wang, Stephanie Gilmore, Izabela Drozdz, Claire Comerford, Jeremy Ryan, Emma Minihane, Salma Parvin, Michael O’Dwyer, John Quinn, Philip Murphy, Simon Furney, Siobhan Glavey, Tríona Ní Chonghaile; Leukemia Research Foundation, Science Foundation Ireland, Breakthrough Cancer Research (Collaborative Group)

https://doi.org/10.3324/haematol.2023.283771

Letters to the Editor

Systemic diffuse large B-cell lymphoma involving the central nervous system have high rates of defective antigen presentation and immune surveillance (657 Online Views)

Joel Wight, Piers Blombery, Jennifer Lickiss, Melinda Burgess, Clare Gould, Adrian Minson, Fiona Swain, Muhammed B. Sabdia, Maher K. Gandhi, Andrew Birchley, Colm Keane, Eliza A Hawkes

https://doi.org/10.3324/haematol.2023.284600

Mar 14, 2024

Editorials
Article

D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells (650 Online Views)

Kathrin Hammon, Kathrin Renner, Michael Althammer, Florian Voll, Nathalie Babl, Sonja-Maria Decking, Peter J. Siska, Carina Matos, Zugey Elizabeth Cárdenas Conejo, Karina Mendes, Friederike Einwag, Heiko Siegmund, Sabine Iberl, Raffaela S. Berger, Katja Dettmer, Rebecca Schoenmehl, Christoph Brochhausen, Wolfgang Herr, Peter J. Oefner, Michael Rehli, Simone Thomas, Marina Kreutz

https://doi.org/10.3324/haematol.2023.283597

Articles

Imatinib treatment and longitudinal growth in pediatric patients with chronic myeloid leukemia: Influence of demographic, pharmacological, and genetic factors in the German CML-PAED cohort (446 Online Views)

Sophie Stiehler, Stephanie Sembill, Oliver Schleicher, Michaela Marx, Manfred Rauh, Manuela Krumbholz, Axel Karow, Meinolf Suttorp, Joachim Woelfle, Carlo Maj, Markus Metzler

https://doi.org/10.3324/haematol.2023.284668

Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment (347 Online Views)

Sarah Liane Linguet, Suzanne Verlhac, Florence Missud, Laurent Holvoet-Vermaut, Valentine Brousse, Ghislaine Ithier, Alexandra Ntorkou, Emmanuelle Lesprit, Malika Benkerrou, Manoëlle Kossorotoff, Berengere Koehl

https://doi.org/10.3324/haematol.2023.283773

Letters to the Editor

Bendamustine and rituximab as first-line treatment for symptomatic splenic marginal zone lymphoma: long-term outcome and impact of early unmeasurable minimal residual disease attainment from the BRISMA/IELSG36 phase II study (553 Online Views)

Emilio Iannitto, Simone Ferrero, Côme Bommier, Daniela Drandi, Martina Ferrante, Krimo Bouabdallah, Sylvain Carras, Guido Gini, Vincent Camus, Salvatrice Mancuso, Luigi Marcheselli, Angela Ferrari, Michele Merli, Benoit Tessoulin, Caterina Stelitano, Kheira Beldjord, Giovanni Roti, Fabrice Jardin, Barbara Castagnari, Francesca Palombi, Lucile Baseggio, Alexandra Traverse-Glehen, Claudio Tripodo, Anna Marina Liberati, Margherita Parolini, Sara Usai, Caterina Patti, Massimo Federico, Maurizio Musso, Marco Ladetto, Emanuele Zucca, Catherine Thieblemont

https://doi.org/10.3324/haematol.2023.284109

Low-dose non-steroidal anti-inflammatory drugs: a promising approach for the treatment of symptomatic bone marrow failure in Ghosal hematodiaphyseal dysplasia (358 Online Views)

Jonathan Bordat, Felipe Suarez, Valérie Cormier-Daire, Regis Peffault de Latour, Jean Soulier, Veronique Meignin, Mathilde Doyard, Lise Larcher, Stephane Vanderbecken, Flore Sicre de Fontbrune

https://doi.org/10.3324/haematol.2023.284098

Case Reports

Classical meets malignant hematology: a case of acquired εγδβ-thalassemia in clonal hematopoiesis (298 Online Views)

Armin P. Piehler, Marietta Truger, Jan-Hendrik Kozik, Sandra Weissmann, Martin Schwonzen, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Gregor Hoermann, Claudia Haferlach

https://doi.org/10.3324/haematol.2024.285083

Mar 7, 2024

Editorials

Editorials
Letter to the Editor

Genomic landscape of patients in a phase II study of zanubrutinib in ibrutinib- and/or acalabrutinib-intolerant patients with B-cell malignancies (663 Online Views)

Linlin Xu, Mazyar Shadman, Ian W. Flinn, Moshe Y. Levy, Ryan Porter, John M. Burke, Syed F. Zafar, Jennifer L. Cultrera, Jamal Misleh, Edwin C. Kingsley, Habte A. Yimer, Benjamin Freeman, Arvind Chaudhry, Praveen K. Tumula, Mitul D. Gandhi, Rocco Crescenzo, Kunthel By, Aileen Cohen, Dih-Yih Chen, Adam Idoine, Sudhir Manda, Jeff P. Sharman, Vanitha Ramakrishnan

https://doi.org/10.3324/haematol.2023.283861

Review Articles

Articles

Cell-free DNA from nail clippings as source of normal control for genomic studies in hematologic malignancies (664 Online Views)

Melissa Krystel-Whittemore, Kseniya Petrova-Drus, Ryan N. Ptashkin, Mark D. Ewalt, JinJuan Yao, Ying Liu, Menglei Zhu, Jamal Benhamida, Benjamin Durham, Jyoti Kumar, Khedoudja Nafa, Iwona Kiecka, Anita S. Bowman, Erika Gedvilaite, Jacklyn Casanova, Yun-Te Lin, Abhinita S. Mohanty, Satshil Rana, Anoop Balakrishnan Rema, Ivelise Rijo, Nelio Chaves, Paulo Salazar, Anita Yun, Sean Lachhander, Wei Wang, Mohammad S. Haque, Wenbin Xiao, Mikhail Roshal, Sergio Giralt, Gilles Salles, Raajit Rampal, Eytan M. Stein, Miguel-Angel Perales, Steven Horwitz, Ann Jakubowski, Doris Ponce, Alina Markova, Ozge Birsoy, Diana Mandelker, Simon Mantha, Ahmet Dogan, Ryma Benayed, Marc Ladanyi, Michael F. Berger, A. Rose Brannon, Ahmet Zehir, Chad Vanderbilt, Maria E. Arcila

https://doi.org/10.3324/haematol.2024.285054

Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease (613 Online Views)

Angelo D’Alessandro, Kang Le, Maureen Lundt, Quan Li, Emily B. Dunkelberger, Troy Cellmer, Andrew J. Worth, Spurthi Patil, Chris Huston, Abby Grier, Monika Dzieciatkowska, Daniel Stephenson, William A. Eaton, Swee Lay Thein

https://doi.org/10.3324/haematol.2023.284831

Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases (457 Online Views)

Faiqa Farrukh, Maymona Abdelmagid, Abhishek Mangaonkar, Mrinal Patnaik, Aref Al-Kali, Michelle A. Elliott, Kebede H. Begna, Christopher C. Hook, William J. Hogan, Animesh Pardanani, Mark R. Litzow, Rhett P. Ketterling, Naseema Gangat, Daniel A. Arber, Attilio Orazi, Rong He, Kaaren Reichard, Ayalew Tefferi

https://doi.org/10.3324/haematol.2023.284719

Impact and utility of follicular lymphoma GELF criteria in routine care: an Australasian Lymphoma Alliance study (514 Online Views)

Allison Barraclough, Shivam Agrawal, Dipti Talaulikar, Geoffrey Chong, Edward Yoo, Chan Y. Cheah, Nunzio Franco, Bianca Nguyen, Howard Mutsando, Fatima Tahir, Judith Trotman, Jing Huang, Colm Keane, Mitchel Lincoln, Tara Cochrane, Anna M. Johnston, Michael Dickinson, Stephen Opat, Zoe K. McQuilten, Erica M. Wood, Gayathri St George, Eliza A. Hawkes

https://doi.org/10.3324/haematol.2023.284538

Small extracellular vesicles derived from acute myeloid leukemia cells promote leukemogenesis by transferring miR-221-3p (708 Online Views)

Mengyu Li, Guohuan Sun, Jinlian Zhao, Shuangshuang Pu, Yanling Lv, Yifei Wang, Yapu Li, Xiangnan Zhao, Yajie Wang, Shangda Yang, Tao Cheng, Hui Cheng

https://doi.org/10.3324/haematol.2023.284145

Letters to the Editor

Incidence and outcome of central nervous system relapse after hematopoietic stem cell transplantation in patients suffering from acute myeloid leukemia and acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (381 Online Views)

Sabine Blum, Yves Chalandon, Myriam Labopin, Jürgen Finke, Tobias Gedde-Dahl, Tarek Ben Othman, Jan J. Cornelissen, Pavel Jindra, Hélène Labussière-Wallet, Matthew Collin, Stig Lenhoff, Guido Kobbe, Norma C. Gutiérrez, Arnon Nagler, Mohamad Mohty

https://doi.org/10.3324/haematol.2023.284858

Case Reports

HJV mutations causing hemochromatosis: variable phenotypic expression in a pair of twins (317 Online Views)

Akhila Vadivelan, Sarah Zhang, Daniel N. Srole, Elizabeth A. Marcus, George Carvalho Neto, Elizabeta Nemeth, Tomas Ganz, Satiro De Oliveira

https://doi.org/10.3324/haematol.2023.284134

Perspective Articles

Feb 29, 2024

Review Articles

Spotlight Review

Articles

B-cell precursor acute lymphoblastic leukemia elicits an interferon-α/β response in bone marrow-derived mesenchymal stroma (421 Online Views)

Mandy W. E. Smeets, Elisabeth M. P. Steeghs, Jan Orsel, Femke Stalpers, Myrthe M. P. Vermeeren, Christina H. J. Veltman, Lotte Slenders, Stefan Nierkens, Cesca van de Ven, Monique L. den Boer

https://doi.org/10.3324/haematol.2023.283494

Characterization of zanubrutinib safety and tolerability profile and comparison with ibrutinib safety profile in patients with B-cell malignancies: post-hoc analysis of a large clinical trial safety database (1636 Online Views)

Jennifer R. Brown, Paolo Ghia, Wojciech Jurczak, Brad S. Kahl, Nicole Lamanna, Tadeusz Robak, Mazyar Shadman, Constantine S. Tam, Lugui Qiu, Jason Paik, Tommi Salmi, Liping Wang, Jun Zhang, Meng Zhang, Aileen Cohen, Han Ma, Alessandra Tedeschi

https://doi.org/10.3324/haematol.2023.283846

UBTF tandem duplications in pediatric myelodysplastic syndrome and acute myeloid leukemia: implications for clinical screening and diagnosis (767 Online Views)

Juan M. Barajas, Masayuki Umeda, Lisett Contreras, Mahsa Khanlari, Tamara Westover, Michael P. Walsh, Emily Xiong, Chenchen Yang, Brittney Otero, Marc Arribas-Layton, Sherif Abdelhamed, Guangchun Song, Xiaotu Ma, Melvin E. Thomas 3rd, Jing Ma, Jeffery M. Klco

https://doi.org/10.3324/haematol.2023.284683

Letters to the Editor

Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia (564 Online Views)

Lena Blumel, Flavia Bernardi, Daniel Picard, Jacob Torrejon Diaz, Vera H. Jepsen, Rebecca Hasselmann, Julian Schliehe-Diecks, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovka, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourqin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer

https://doi.org/10.3324/haematol.2023.283928

Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia (528 Online Views)

Shannon L. Carey-Smith, Maryam H. Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Sang Lin, Jesse D. Armitage, Vivien T. Nguyen, Kathryn Bentley, Jette Ford, Sajla Singh, Joyce Oommen, Anouchka P. Laurent, Thomas Mercher, John D. Crispino, Andrew P. Montgomery, Michael Kassiou, Thierry Besson, Emmanuel Deau, Laurent Meijer, Laurence C. Cheung, Rishi S. Kotecha, Sébastien Malinge

https://doi.org/10.3324/haematol.2023.284271

Mycophenolate mofetil is associated with inferior overall survival in cytomegalovirus seropositive patients with acute myeloid leukemia undergoing hematopoietic cell transplantation (349 Online Views)

Rima M. Saliba, Stephanie J. Lee, Paul A Carpenter, Geoffrey R Hill, Catherine J. Lee, Amin Alousi, May Daher, George Chen, Richard E. Champlin, Katayoun Rezvani, Elizabeth J. Shpall, Rohtesh S. Mehta

https://doi.org/10.3324/haematol.2023.284501

Health-related quality of life in relapsed/refractory multiple myeloma treated with melflufen and dexamethasone: analyses from the phase III OCEAN study (858 Online Views)

Fredrik H. Schjesvold, Heinz Ludwig, Sossana Delimpasi, Pawel Robak, Daniel Coriu, Waldemar Tomczak, Ludek Pour, Ivan Spicka, Meletios-Athanasios Dimopoulos, Tamas Masszi, Natalia G. Chernova, Anna Sandberg, Marcus Thuresson, Stefan Norin, Nicolaas A. Bakker, Maria-Victoria Mateos, Paul G. Richardson, Pieter Sonneveld

https://doi.org/10.3324/haematol.2023.284635

Feb 22, 2024

Editorials
Article

Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma (1262 Online Views)

Stien De Coninck, Renate De Smedt, Beatrice Lintermans, Lindy Reunes, Hansen J. Kosasih, Alexandra Reekmans, Lauren M. Brown, Nadine Van Roy, Bruno Palhais, Juliette Roels, Malaika Van der Linden, Jo Van Dorpe, Panagiotis Ntziachristos, Frederik W. van Delft, Marc R. Mansour, Tim Pieters, Tim Lammens, Barbara De Moerloose, Charles E. de Bock, Steven Goossens, Pieter Van Vlierberghe

https://doi.org/10.3324/haematol.2023.283981

Articles

Transfusion of ever-pregnant donor red blood cells and mortality of male patients (260 Online Views)

Sarah J. Valk, Camila Caram-Deelder, Rolf. H.H. Groenwold, Dorothea Evers, Karen M.K. de Vooght, Daan van de Kerkhof, Marielle J Wondergem, Nathalie C.V. Péquériaux, Francisca Hudig, Jaap Jan Zwaginga, Rutger A. Middelburg, Johanna G. van der Bom

https://doi.org/10.3324/haematol.2023.283550

Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842 (608 Online Views)

Haiping Luo, Qiqi Li, Jiaxin Hong, Zhibin Huang, Wenhui Deng, Kunpeng Wei, Siyu Lu, Hailong Wang, Wenqing Zhang, Wei Liu

https://doi.org/10.3324/haematol.2023.283647

Outcome of primary hemophagocytic lymphohistiocytosis: a report on 143 patients from the Italian Registry (484 Online Views)

Francesco Pegoraro, Aurora Chinnici, Linda Beneforti, Michele Tanturli, Irene Trambusti, Carmela De Fusco, Concetta Micalizzi, Veronica Barat, Simone Cesaro, Stefania Gaspari, Fabiola Dell’Acqua, Alessandra Todesco, Fabio Timeus, Maurizio Aricò, Claudio Favre, Annalisa Tondo, Maria Luisa Coniglio, Elena Sieni; AIEOP Histiocytosis Working Group (Collaborative Group)

https://doi.org/10.3324/haematol.2023.283893

IELSG38: phase II trial of front-line chlorambucil plus subcutaneous rituximab induction and maintenance in mucosa-associated lymphoid tissue lymphoma (687 Online Views)

Anastasios Stathis, Maria Cristina Pirosa, Lorella Orsucci, Pierre Feugier, Monica Tani, Hervé Ghesquières, Gerardo Musuraca, Francesca Gaia Rossi, Francesco Merli, Romain Guièze, Emmanuel Gyan, Guido Gini, Dario Marino, Remy Gressin, Franck Morschhauser, Federica Cavallo, Francesca Palombi, Annarita Conconi, Benoît Tessoulin, Hervé Tilly, Manuela Zanni, Maria Giuseppina Cabras, Enrico Capochiani, Catello Califano, Melania Celli, Alessandro Pulsoni, Francesco Angrilli, Ubaldo Occhini, René-Olivier Casasnovas, Guillaume Cartron, Liliana Devizzi, Corinne Haioun, Anna Marina Liberati, Roch Houot, Michele Merli, Giuseppe Pietrantuono, Francesca Re, Michele Spina, Francesco Landi, Franco Cavalli, Francesco Bertoni, Davide Rossi, Nicoletta Ielmini, Elena Borgo, Stefano Luminari, Emanuele Zucca, Catherine Thieblemont

https://doi.org/10.3324/haematol.2023.283918

A predictive classifier of poor prognosis in transplanted patients with juvenile myelomonocytic leukemia: a study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (469 Online Views)

Déborah Meyran, Chloé Arfeuille, Sylvie Chevret, Quentin Neven, Aurélie Caye-Eude, Elodie Lainey, Arnaud Petit, Fanny Rialland, Gérard Michel, Dominique Plantaz, Charlotte Jubert, Alexandre Theron, Virginie Gandemer, Marie Ouachée-Chardin, Catherine Paillard, Bénédicte Bruno, Nimrod Buchbinder, Cécile Pochon, Charlotte Calvo, Mony Fahd, André Baruchel, Hélène Cavé, Jean-Hugues Dalle, Marion Strullu

https://doi.org/10.3324/haematol.2023.284103

Enhancement of PRMT6 binding to a novel germline GATA1 mutation associated with congenital anemia (531 Online Views)

Yingsi Lu, Qingqing Zhu, Yun Wang, Meiling Luo, Junbin Huang, Qian Liang, Lifen Huang, Jing Ouyang, Chenxin Li, Nannan Tang, Yan Li, Tingting Kang, Yujia Song, Xiaoyu Xu, Liping Ye, Guoxing Zheng, Chun Chen, Chengming Zhu

https://doi.org/10.3324/haematol.2023.284183

Selective pharmacologic targeting of CTPS1 shows single-agent activity and synergizes with BCL2 inhibition in aggressive mantle cell lymphoma (437 Online Views)

Romane Durand, Céline Bellanger, Charlotte Kervoëlen, Benoit Tessoulin, Christelle Dousset, Emmanuelle Menoret, Hélène Asnagli, Andrew Parker, Philip Beer, Catherine Pellat-Deceunynck, David Chiron

https://doi.org/10.3324/haematol.2023.284345

A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma (719 Online Views)

Hayley M. Sabol, Cody Ashby, Manish Adhikari, Aric Anloague, Japneet Kaur, Sharmin Khan, Samrat Roy Choudhury, Carolina Schinke, Michela Palmieri, C. Lowry Barnes, Elena Ambrogini, Intawat Nookaew, Jesus Delgado-Calle

https://doi.org/10.3324/haematol.2023.284443

Genomic profiling of pediatric hematologic malignancies and diagnosis of cancer predisposition syndromes: tumor-only versus paired tumor-normal sequencing (427 Online Views)

Haley Newman, Mary Egan Clark, Derek Wong, Jinhua Wu, Garrett M Brodeur, Stephen P Hunger, Sarah K Tasian, Timothy Olson, Julia T. Warren, David T Teachey, Kira Bona, Jeffrey Schubert, Netta Golenberg, Maha Patel, Elizabeth H Denenberg, Elizabeth A Fanning, Jiani Chen, Tamara Luke, Sarah Charles, Daniel Gallo, Kajia Cao, Weixuan Fu, Zhiqian Fan, Lea F Surrey, Gerald Wertheim, Minjie Luo, Suzanne P MacFarland, Marilyn M Li, Yiming Zhong

https://doi.org/10.3324/haematol.2023.284855

Letters to the Editor

Pubertal development of transfusion-dependent thalassemia patients in the era of oral chelation with deferasirox: results from the French registry (307 Online Views)

Mathilde Veneziano Broccia, Julia Vergier, Audrey Benoit, Yoann Huguenin, Anne Lambilliotte, Marie Pierre Castex, Stephanie Gourdon, Ghislaine Ithier, Kamila Kebaili, Pierre Rohrlich, Corinne Pondarre, Abdourahim Chamouine, Pauline Simon, Kokou Placide Agbo Kpati, Slimane Allali, Sandrine Baron-Joly, Sophie Bayart, Nicolas Billaud, Valentine Brousse, Cecile Dumesnil, Nathalie Garnier, Isabelle Guichard, Laure Joseph, Annie Kamdem, Julie Maitre, Catherine Mathey, Catherine Paillard, Aurelie Phulpin, Cecile Renard, Cecile Stoven, Mohamed Touati, Capucine Trochu, Suzanne Mathieu Nafissi, Catherine Badens, Sarah Szepetowski, Isabelle Thuret

https://doi.org/10.3324/haematol.2023.283610

Belantamab mafodotin: an important treatment option for vulnerable patients with triple class exposed relapsed and/or refractory multiple myeloma (542 Online Views)

Maria Victoria Mateos, Katja Weisel, Evangelos Terpos, Sossana Delimpasi, Efstathios Kastritis, Elena Zamagni, Michel Delforge, Enrique Ocio, Eirini Katodritou, Francesca Gay, Alessandra Larocca, Xavier Leleu, Paula Rodriguez Otero, Fredik Schjesvold, Michele Cavo, Meletios A. Dimopoulos

https://doi.org/10.3324/haematol.2023.284694

TP53 DNA binding domain mutational status and rituximab-based treatment are independent prognostic factors for pediatric Burkitt lymphoma patients stratification (394 Online Views)

Gaia Martire, Federica Lovisa, Elisa Carraro, Domenico Rizzato, Simone Cesaro, Rosa Maria Mura, Annalisa Tondo, Cinzia Bertolin, Francesca Boaretto, Leonardo Salviati, Alessandra Biffi, Marta Pillon, Lara Mussolin

https://doi.org/10.3324/haematol.2023.284868

Case Reports

Phenomenon of tumor flare with talquetamab in a patient with extramedullary myeloma (427 Online Views)

Mark Forsberg, Santiago Beltran, Mendel Goldfinger, Murali Janakiram, Deepak Kalbi, Amit Verma, Dennis Cooper, Nishi Shah

https://doi.org/10.3324/haematol.2023.284436

Feb 15, 2024

Editorials
Article

Matching-adjusted indirect comparison from the Lymphoma Epidemiology of Outcomes Consortium for Real World Evidence (LEO CReWE) study to a clinical trial of mosunetuzumab in relapsed or refractory follicular lymphoma (1025 Online Views)

Matthew J. Maurer, Carla Casulo, Melissa C. Larson, Thomas M. Habermann, Izidore S. Lossos, Yucai Wang, Loretta J. Nastoupil, Christopher Strouse, Dai Chihara, Peter Martin, Jonathon B. Cohen, Brad S. Kahl, W Richard Burack, Jean L. Koff, Yong Mun, Anthony Masaquel, Mei Wu, Michael C. Wei, Ashwini Shewade, Jia Li, James R. Cerhan, Brian K. Link, Christopher R. Flowers

https://doi.org/10.3324/haematol.2023.283737

Review Articles

Spotlight Review

Articles

Selinexor, daratumumab, bortezomib and dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma: results of the phase II, non-randomized, multicenter GEM-SELIBORDARA study (1178 Online Views)

Verónica González-Calle, Paula Rodríguez-Otero, Anna Sureda, Felipe de Arriba, Marta Reinoso, Paz Ribas, Ana Pilar González-Rodríguez, Yolanda González, Albert Oriol, Joaquín Martínez-López, Marta Sonia González, Miguel T. Hernández, Maialen Sirvent, Teresa Cedena, Noemí Puig, Bruno Paiva, Joan Bladé, Juan José Lahuerta, Jesús F. San-Miguel, María-Victoria Mateos

https://doi.org/10.3324/haematol.2023.284089

ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression (786 Online Views)

Wenqian Xu, Feng Tian, Xiaolu Tai, Gaoxian Song, Yuanfang Liu, Liquan Fan, Xiangqin Weng, Eunjeong Yang, Meng Wang, Martin Bornhäuser, Chao Zhang, Richard B. Lock, Jason W.H. Wong, Jin Wang, Duohui Jing, Jian-Qing Mi

https://doi.org/10.3324/haematol.2023.284121

Belantamab mafodotin, lenalidomide and dexamethasone in transplant-ineligible patients with newly diagnosed multiple myeloma: Part 1 results of a phase I/II study (623 Online Views)

Evangelos Terpos, Maria Gavriatopoulou, Ioannis Ntanasis-Stathopoulos, Panagiotis Malandrakis, Despina Fotiou, Magdalini Migkou, Foteini Theodorakakou, Vasiliki Spiliopoulou, Ioannis V Kostopoulos, Rodanthi-Eleni Syrigou, Evangelos Eleutherakis-Papaiakovou, Stavros Gkolfinopoulos, Ourania E Tsitsilonis, Efstathios Kastritis, Meletios A. Dimopoulos

https://doi.org/10.3324/haematol.2023.284347

Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study (549 Online Views)

Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek

https://doi.org/10.3324/haematol.2023.284390

Guidelines

Approaches for bridging therapy prior to chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic B-lineage leukaemia in children and young adults (695 Online Views)

Tobias Feuchtinger, Peter Bader, Marion Subklewe, Maike Breidenbach, Semjon Willier, Markus Metzler, Nicola Gökbuget, Julia Hauer, Fabian Müller, Paul-Gerhardt Schlegel, Michael Frühwald, Christoph Schmid, Anja Troeger, Claudia Baldus, Roland Meisel, Annette Künkele, Max Topp, Jean-Pierre Bourquin, Gunnar Cario, Arend von Stackelberg, Christina Peters

https://doi.org/10.3324/haematol.2023.283780

Feb 8, 2024

Review Articles

Articles

Feb 1, 2024

Articles

Patterns of lower risk myelodysplastic syndrome progression: factors predicting progression to high-risk myelodysplastic syndrome and acute myeloid leukemia (831 Online Views)

Akriti G. Jain, Somedeb Ball, Luis Aguirre, Najla Al Ali, David Kaldas, Sara Tinsley-Vance, Andrew Kuykendall, Onyee Chan, Kendra Sweet, Jeffrey E. Lancet, Eric Padron, David A. Sallman, Rami Komrokji

https://doi.org/10.3324/haematol.2023.283661

CD74 is expressed in a subset of pediatric acute myeloid leukemia patients and is a promising target for therapy: a report from the Children’s Oncology Group (538 Online Views)

Andrew J. Menssen, Chad A. Hudson, Todd Alonzo, Robert Gerbing, Laura Pardo, Amanda Leonti, Jacqueline A. Cook, Fan-Chi Hsu, Loren L. Lott, Fangyan Dai, Collette Fearing, Keely Ghirardelli, Tiffany Hylkema, Katherine Tarlock, Keith R. Loeb, Edward A. Kolb, Todd Cooper, Jessica Pollard, Denise A. Wells, Michael R. Loken, Richard Aplenc, Soheil Meshinchi, Lisa Eidenschink Brodersen

https://doi.org/10.3324/haematol.2023.283757

Isatuximab-pomalidomide-dexamethasone versus pomalidomide-dexamethasone in patients with relapsed and refractory multiple myeloma: final overall survival analysis (1976 Online Views)

Paul G. Richardson, Aurore Perrot, Jesus San Miguel, Meral Beksac, Ivan Spicka, Xavier Leleu, Fredrik Schjesvold, Philippe Moreau, Meletios A. Dimopoulos, Shang-Yi Huang, Jiri Minarik, Michele Cavo, H. Miles Prince, Sandrine Macé, Rick Zhang, Franck Dubin, Mony Chenda Morisse, Kenneth C. Anderson

https://doi.org/10.3324/haematol.2023.284325

Jan 25, 2024

Editorials

Articles

Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy (609 Online Views)

Mika Casey, Carol Lee, Sharon M. Hoyte, Rebecca L. Johnston, Wing Yu Kwok, Soi Cheng Law, Maher K Gandhi, Simon J Harrison, Kyohei Nakamura

https://doi.org/10.3324/haematol.2023.284435

Letters to the Editor

Genomic landscape of patients in a phase II study of zanubrutinib in ibrutinib- and/or acalabrutinib-intolerant patients with B-cell malignancies (663 Online Views)

Linlin Xu, Mazyar Shadman, Ian W. Flinn, Moshe Y. Levy, Ryan Porter, John M. Burke, Syed F. Zafar, Jennifer L. Cultrera, Jamal Misleh, Edwin C. Kingsley, Habte A. Yimer, Benjamin Freeman, Arvind Chaudhry, Praveen K. Tumula, Mitul D. Gandhi, Rocco Crescenzo, Kunthel By, Aileen Cohen, Dih-Yih Chen, Adam Idoine, Sudhir Manda, Jeff P. Sharman, Vanitha Ramakrishnan

https://doi.org/10.3324/haematol.2023.283861

Jan 18, 2024

Articles

Phase I study of the Syk inhibitor sovleplenib in relapsed or refractory mature B-cell tumors (612 Online Views)

Yuqin Song, Junning Cao, Qingyuan Zhang, Caixia Li, Lugui Qiu, Junyuan Qi, Huilai Zhang, Wenyu Li, Lihong Liu, Hongmei Jing, Keshu Zhou, Weijing Zhang, Liling Zhang, Daqi Li, Liqun Zou, Haiyan Yang, Wenbin Qian, Hui Zhou, Jianda Hu, Hongyan Yin, Sisi Fu, Songhua Fan, Qian Xu, Jian Wang, Xiaoyun Jia, Guangxiu Dai, Weiguo Su, Jun Zhu

https://doi.org/10.3324/haematol.2022.282401

D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells (650 Online Views)

Kathrin Hammon, Kathrin Renner, Michael Althammer, Florian Voll, Nathalie Babl, Sonja-Maria Decking, Peter J. Siska, Carina Matos, Zugey Elizabeth Cárdenas Conejo, Karina Mendes, Friederike Einwag, Heiko Siegmund, Sabine Iberl, Raffaela S. Berger, Katja Dettmer, Rebecca Schoenmehl, Christoph Brochhausen, Wolfgang Herr, Peter J. Oefner, Michael Rehli, Simone Thomas, Marina Kreutz

https://doi.org/10.3324/haematol.2023.283597

Pediatric-inspired regimen for adolescent and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia: a prospective study from China (786 Online Views)

Xiaoyuan Gong, Qiuyun Fang, Runxia Gu, Shaowei Qiu, Kaiqi Liu, Dong Lin, Chunlin Zhou, Guangji Zhang, Benfa Gong, Yuntao Liu, Yan Li, Bingcheng Liu, Ying Wang, Hui Wei, Yingchang Mi, Jianxiang Wang

https://doi.org/10.3324/haematol.2023.284228

Carfilzomib, thalidomide, and dexamethasone is safe and effective in relapsed and/or refractory multiple myeloma: final report of the single arm, multicenter phase II ALLG MM018/AMN002 study. (602 Online Views)

Slavisa Ninkovic, Simon J Harrison, Je-Jung Lee, Nick Murphy, Jae Hoon Lee, Jane Estell, Vivien M Chen, Noemi Horvath, Kihuyn Kim, Richard Eek, Bradley Augustson, Soo-Mee Bang, Shang-Yi Huang, Rajeev Rajagopal, Ferenc Szabo, Daniel Engeler, Belinda E Butcher, Peter Mollee, Brian Durie, Wee Joo Chng, Hang Quach

https://doi.org/10.3324/haematol.2023.284238

Autologous stem cell transplant in fit patients with refractory or early relapsed diffuse large B-cell lymphoma that responded to salvage chemotherapy (928 Online Views)

Aung M. Tun, Yucai Wang, Seth Maliske, Ivana Micallef, David J. Inwards, Thomas M. Habermann, Luis Porrata, Jonas Paludo, Jose Villasboas Bisneto, Allison Rosenthal, Mohamed A Kharfan-Dabaja, Stephen M. Ansell, Grzegorz S. Nowakowski, Umar Farooq, Patrick B. Johnston

https://doi.org/10.3324/haematol.2023.284704

Jan 11, 2024

Articles

Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease (881 Online Views)

Mateo Sarmiento Bustamante, Sheila K. Pierson, Yue Ren, Adam Bagg, Joshua D. Brandstadter, Gordan Srkalovic, Natalie Mango, Daisy Alapat, Mary Jo Lechowicz, Hongzhe Li, Frits van Rhee, Megan S. Lim, David C. Fajgenbaum

https://doi.org/10.3324/haematol.2023.283603

Elucidation of molecular basis of osteolytic bone lesions in advanced multiple myeloma (748 Online Views)

Dongyeop Shin, Myung-Jin Kim, Soyeon Chun, Dongchan Kim, Chansu Lee, Kwang-Sung Ahn, Eunyoung Jung, Dayeon Kim, Byung-Chul Lee, Daehee Hwang, Yonghwan Kim, Sung-Soo Yoon

https://doi.org/10.3324/haematol.2023.283784

Prior cancer and risk of monoclonal gammopathy of undetermined significance: a population-based study in Iceland and Sweden (641 Online Views)

Sæmundur Rögnvaldsson, Sigrun Thorsteinsdóttir, Elisavet Syriopoulou, Ingigerdur Sverrisdottir, Ingemar Turesson, Elias Eythorsson, Jon Thorir Oskarsson, Thorir Einarsson Long, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni A. Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir, Thor Aspelund, Gauti Kjartan Gislason, Andri Olafsson, Jon Kristinn Sigurdsson, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Magnus Bjorkholm, Ola Landgren, Thorvardur Jon Love, Sigurdur Yngvi Kristinsson

https://doi.org/10.3324/haematol.2023.284365

Jan 4, 2024

Articles

Matched unrelated donor transplantation versus haploidentical transplantation with post-transplant cyclophosphamide in children with acute myeloid leukemia: a PDWP-EBMT study (1105 Online Views)

Annalisa Ruggeri, Nicole Santoro, Jacques-Emmanuel Galimard, Krzysztof Kalwak, Mattia Algeri, Ludmila Zubarovskaya, Krzysztof Czyzewski, Elena Skorobogatova, Petr Sedlacek, Caroline Besley, Adriana Balduzzi, Yves Bertrand, Julia Peristeri, Franca Fagioli, Mariane Ifversen, Jolanta Gozdzik, Christina Peters, Birgitta Versluijs, Alessandra Biffi, Arcangelo Prete, Maura Faraci, Ibrahim Ghemlas, Ivana Bodova, Olga Aleinikova, Arnaud Dalissier, Vanderson Rocha, Selim Corbacioglu

https://doi.org/10.3324/haematol.2023.284445

Inotuzumab ozogamicin combined with chemotherapy in pediatric B-cell precursor CD22+ acute lymphoblastic leukemia: results of the phase IB ITCC-059 trial (951 Online Views)

Edoardo Pennesi, Erica Brivio, Anneke C. J. Ammerlaan, Yilin Jiang, Vincent H. J. van der Velden, H. Berna Beverloo, Barbara Sleight, Franco Locatelli, Benoit Brethon, Claudia Rossig, Gernot Engstler, Anna Nilsson, Benedicte Bruno, Arnaud Petit, Bella Bielorai, Carmelo Rizzari, Fanny Rialland, Alba Rubio-San-Simón, Francisco J. Bautista Sirvent, Cristina Diaz-de-Heredia, Susana Rives, Christian M. Zwaan

https://doi.org/10.3324/haematol.2023.284409

Case Reports

Dec 28, 2023

Articles

LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia (953 Online Views)

Astrid Wintering, Anna Hecht, Julia Meyer, Eric B. Wong, Juwita Hübner, Sydney Abelson, Kira Feldman, Vanessa E. Kennedy, Cheryl A.C. Peretz, Deborah L. French, Jean Ann Maguire, Chintan Jobaliya, Marta Rojas Vasquez, Sunil Desai, Robin Dulman, Eneida Nemecek, Hilary Haines, Mahmoud Hammad, Alaa El Haddad, Scott C. Kogan, Zied Abdullaev, Farid F. Chehab, Sarah K. Tasian, Catherine C. Smith, Mignon L. Loh, Elliot Stieglitz

https://doi.org/10.3324/haematol.2023.283776

TLR3 agonism augments CD47 inhibition in acute myeloid leukemia (737 Online Views)

Haley E. Ramsey, Agnieszka E. Gorska, Brianna N. Smith, Andrew J. Monteith, Londa Fuller, Maria P. Arrate, Michael R. Savona

https://doi.org/10.3324/haematol.2023.283850

Dec 14, 2023

Guidelines

Nov 30, 2023

Articles

Matching-adjusted indirect comparison from the Lymphoma Epidemiology of Outcomes Consortium for Real World Evidence (LEO CReWE) study to a clinical trial of mosunetuzumab in relapsed or refractory follicular lymphoma (1025 Online Views)

Matthew J. Maurer, Carla Casulo, Melissa C. Larson, Thomas M. Habermann, Izidore S. Lossos, Yucai Wang, Loretta J. Nastoupil, Christopher Strouse, Dai Chihara, Peter Martin, Jonathon B. Cohen, Brad S. Kahl, W Richard Burack, Jean L. Koff, Yong Mun, Anthony Masaquel, Mei Wu, Michael C. Wei, Ashwini Shewade, Jia Li, James R. Cerhan, Brian K. Link, Christopher R. Flowers

https://doi.org/10.3324/haematol.2023.283737

Nov 16, 2023

Articles

Germline bi-allelic SH2B3/LNK alteration predisposes to a neonatal juvenile myelomonocytic leukemia-like disorder (773 Online Views)

Chloé Arfeuille, Yoann Vial, Margaux Cadenet, Aurélie Caye-Eude, Odile Fenneteau, Quentin Neven, Adeline A Bonnard, Simone Pizzi, Giovanna Carpentieri, Yline Capri, Katia Girardi, Lucia Pedace, Marina Macchiaiolo, Kamel Boudhar, Monia ben Khaled, Wadih Abou Chahla, Anne Lutun, Mony Fahd, Séverine Drunat, Elisabetta Flex, Jean-Hugues Dalle, Marion Strullu, Franco Locatelli, Marco Tartaglia, Hélène Cavé

https://doi.org/10.3324/haematol.2023.283917

Pilot study of lung cancer screening for survivors of Hodgkin lymphoma (460 Online Views)

Rachel Broadbent, Philip Crosbie, Christopher J. Armitage, Ben Taylor, Sean Tenant, Joseph Mercer, John Radford, Kim Linton

https://doi.org/10.3324/haematol.2023.283287

Oct 26, 2023

Articles

A Japanese retrospective study of non-tuberculous mycobacterial infection in children, adolescents, and young adult patients with hematologic-oncologic diseases (717 Online Views)

Yusuke Tsumura, Hideki Muramatsu, Nobuyuki Tetsuka, Takahiro Imaizumi, Kikue Sato, Kento Inoue, Yoshitomo Motomura, Yuko Cho, Daiki Yamashita, Daichi Sajiki, Ryo Maemura, Ayako Yamamori, Masayuki Imaya, Manabu Wakamatsu, Kotaro Narita, Shinsuke Kataoka, Motoharu Hamada, Rieko Taniguchi, Eri Nishikawa, Atsushi Narita, Nobuhiro Nishio, Seiji Kojima, Yoshihiko Hoshino, Yoshiyuki Takahashi

https://doi.org/10.3324/haematol.2023.283636

Aug 19, 2021

Errata Corrige

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (3635 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2021.279802

May 10, 2018

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells (1380 Online Views)

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

https://doi.org/10.3324/haematol.2018.189399