Early view

Feb 18, 2021

Articles

Identification of a novel genetic locus associated with immune mediated thrombotic thrombocytopenic purpura

Matthew J Stubbs, Paul Coppo, Chris Cheshire, Agnès Veyradier, Stephanie Dufek, Adam P Levine, Mari Thomas, Vaksha Patel, John O Connolly, Michael Hubank, Ygal Benhamou, Lionel Galicier, Pascale Poullin, Robert Kleta, Daniel P Gale, Horia Stanescu, Marie A Scully

https://doi.org/10.3324/haematol.2020.274639

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E Robinson, Valentina S Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris

https://doi.org/10.3324/haematol.2020.274480

The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia

Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak

https://doi.org/10.3324/haematol.2020.263756

Letters to the Editor

The TRPV2 channel mediates Ca2+ influx and the Δ9-THC-dependent decrease in osmotic fragility in red blood cells

Anouar Belkacemi, Claudia Fecher Trost, René Tinschert, Daniel Flormann, Mahsa Malihpour, Christian Wagner, Markus R Meyer, Andreas Beck, Veit Flockerzi

https://doi.org/10.3324/haematol.2020.274951

Case Reports

Light chain proteinuria revealing mu-heavy chain disease: an atypical presentation of Waldenström macroglobulinemia in two cases

Hélène Vergneault, Djaouida Bengoufa, Aline Frazier-Mironer, Isabelle Brocheriou, Samuel Bitoun, Camille Villesuzanne, Alexis Talbot, Stéphanie Harel, Bertrand Arnulf, Bruno Royer

https://doi.org/10.3324/haematol.2020.277137

A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria

Sarah Ducamp, Sara Luscieti, Xènia Ferrer-Cortès, Gaël Nicolas, Hana Manceau, Katell Peoc’h, Yvette Y Yien, Caroline Kannengiesser, Laurent Gouya, Herve Puy, Mayka Sanchez

https://doi.org/10.3324/haematol.2020.272450

Feb 11, 2021

Editorials
Article

Crucial role of hematopoietic JAK2V617F in the development of aortic aneurysms

Tetsuro Yokokawa, Tomofumi Misaka, Yusuke Kimishima, Kento Wada, Keiji Minakawa, Koichi Sugimoto, Takafumi Ishida, Soji Morishita, Norio Komatsu, Kazuhiko Ikeda, Yasuchika Takeishi

https://doi.org/10.3324/haematol.2020.264085

Articles

Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia

Marion K. Mateos, Glenn M. Marshall, Pasquale M. Barbaro, Michael C.J. Quinn, Carly George, Chelsea Mayoh, Rosemary Sutton, Tamas Revesz, Jodie E. Giles, Draga Barbaric, Frank Alvaro, Françoise Mechinaud, Daniel Catchpoole, John A. Lawson, Georgia Chenevix-Trench, Stuart MacGregor, Rishi S. Kotecha, Luciano Dalla-Pozza, Toby N. Trahair

https://doi.org/10.3324/haematol.2020.268565

Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes

Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Giovanni A.M. Povoleri, Jessica A. Timms, Shahram Kordasti, Tanja D. de Gruijl, Arjan A. van de Loosdrecht

https://doi.org/10.3324/haematol.2020.268136

Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis

Rachel Dobson, Peter Y. Du, Lívia Rásó-Barnett, Wen-Qing Yao, Zi Chen, Calogero Casa, Hesham EI-Daly, Lorant Farkas, Elizabeth Soilleux, Penny Wright, John W. Grant, Manuel Rodriguez-Justo, George A. Follows, Hala Rashed, Margarete Fabre, E. Joanna Baxter, George Vassiliou, Andrew Wotherspoon, Ayoma D. Attygalle, Hongxiang Liu, Ming-Qing Du

https://doi.org/10.3324/haematol.2020.265991

Loss of interleukin-10 activates innate immunity to eradicate adult T cell leukemia initiating cells

Hiba El Hajj, Rita Hleihel, Marwan El Sabban, Julie Bruneau, Ghazi Zaatari, Morgane Cheminant, Ambroise Marçais, Abdou Akkouche, Hideki Hasegawa, William Hall, Hugues De Thé, Olivier Hermine, Ali Bazarbachi

https://doi.org/10.3324/haematol.2020.264523

Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates

Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano Jr.

https://doi.org/10.3324/haematol.2020.260059

Feb 4, 2021

Editorials
Article

Outcomes of Burkitt's lymphoma with central nervous system involvement: evidence from a large multi-center cohort study

Adam S. Zayac, Andrew M. Evens, Alexey Danilov, Stephen D. Smith, Deepa Jagadeesh, Lori A. Leslie, Catherine Wei, Seo-Hyun Kim, Seema Naik, Suchitra Sundaram, Nishitha Reddy, Umar Farooq, Vaishalee P. Kenkre, Narendranath Epperla, Kristie A. Blum, Nadia Khan, Daulath Singh, Juan P. Alderuccio, Amandeep Godara, Maryam Sarraf Yazdy, Catherine Diefenbach, Emma Rabinovich, Gaurav Varma, Reem Karmali, Yusra Shao, Asaad Trabolsi, Madelyn Burkart, Peter Martin, Sarah Stettner, Ayushi Chauhan, Yun Kyong Choi, Allandria Straker-Edwards, Andreas Klein, Michael C. Churnetski, Kirsten M. Boughan, Stephanie Berg, Bradley M. Haverkos, Victor M. Orellana-Noia, Christopher D'Angelo, David A. Bond, Seth M. Maliske, Ryan Vaca, Gabriella Magarelli, Amy Sperling, Max J. Gordon, Kevin A. David, Malvi Savani, Paolo Caimi, Manali Kamdar, Matthew A Lunning, Neil Palmisiano, Parameswaran Venugopal, Craig A. Portell, Veronika Bachanova, Tycel Phillips, Izidore S. Lossos, Adam J. Olszewski

https://doi.org/10.3324/haematol.2020.270876

Editorials
Article

Mobilization efficiency is critically regulated by fat via marrow PPARδ

Tomohide Suzuki, Shinichi Ishii, Masakazu Shinohara, Yuko Kawano, Kanako Wakahashi, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Michito Hamada, Satoru Takahashi, Tomoyuki Furuyashiki, Nguan Soon Tan, Toshimitsu Matsui, Yoshio Katayama

https://doi.org/10.3324/haematol.2020.265751

Editorials
Article

Endogenous and combination retinoids are active in myelomonocytic leukemias

Orsola di Martino, Haixia Niu, Gayla Hadwiger, Heikki Kuusanmaki, Margaret A. Ferris, Anh Vu, Jeremy Beales, Carl Wagner, María P. Menéndez-Gutiérrez, Mercedes Ricote, Caroline Heckman, John S. Welch

https://doi.org/10.3324/haematol.2020.264432

Editorials
Article

A multicenter total therapy strategy for de novo adult Philadelphia chromosome positive acute lymphoblastic leukemia patients. Final results of the GIMEMA LAL1509 protocol

Sabina Chiaretti, Michela Ansuinelli, Antonella Vitale, Loredana Elia, Mabel Matarazzo, Alfonso Piciocchi, Paola Fazi, Francesco Di Raimondo, Lidia Santoro, Francesco Fabbiano, Catello Califano, Giovanni Martinelli, Francesca Ronco, Felicetto Ferrara, Nicola Cascavilla, Catia Bigazzi, Alessandra Tedeschi, Simona Sica, Nicola Di Renzo, Angela Melpignano, Germana Beltrami, Marco Vignetti, Robin Foa

https://doi.org/10.3324/haematol.2020.260935

Editorials
Article

Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial

Veronika Brixner, Gesine Bug, Petra Pohler, Doris Krämer, Bernd Metzner, Andreas Voß, Jochen Casper, Ulrich Ritter, Stefan Klein, Nael Alakel, Rudolf Peceny, Hans G. Derigs, Frank Stegelmann, Martin Wolf, Hubert Schrezenmeier, Thomas Thiele, Erhard Seifried, Hans-Hermann Kapels, Andrea Döscher, Eduard K. Petershofen, Thomas H. Müller, Axel Seltsam

https://doi.org/10.3324/haematol.2020.260430

Editorials
Article

Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T cell responses in a murine acute myeloid leukemia model

Dina Stroopinsky, Jessica Liegel, Manoj Bhasin, Giulia Cheloni, Beena Thomas, Swati Bhasin, Ruchit Panchal, Haider Ghiasuddin, Maryam Rahimian, Myrna Nahas, Shira Orr, Marzia Capelletti, Daniela Torres, Cansu Tacettin, Matthew Weinstock, Lina Bisharat, Adam Morin, Kathleen M. Mahoney, Benjamin Ebert, Richard Stone, Donald Kufe, Gordon J. Freeman, Jacalyn Rosenblatt, David Avigan

https://doi.org/10.3324/haematol.2020.259457

Jan 28, 2021

Articles

A novel combination regimen of BET and FLT3 inhibition for FLT3-ITD acute myeloid leukemia

Lauren Lee, Yoshiyuki Hizukuri, Paul Severson, Benjamin Powell, Chao Zhang, Yan Ma, Maiko Narahara, Hiroyuki Sumi, Daniela Hernandez, Trivikram Rajkhowa, Gideon Bollag, Mark Levis

https://doi.org/10.3324/haematol.2020.247346

Letters to the Editor

Entospletinib and obinutuzumab in patients with relapsed/refractory chronic lymphocytic leukemia and B-cell malignancies

Adam S. Kittai, Scott Best, Bria Thurlow, Vi Lam, Taylor Hashiguchi, Shaun Goodyear, Daniel O. Persky, Craig Okada, Byung Park, Stephen E. Spurgeon, Alexey V. Danilov

https://doi.org/10.3324/haematol.2020.270298

An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia

Yoichi Tanaka, Allen Eng Juh Yeoh, Takaya Moriyama, Chi-Kong Li, Ko Kudo, Yuki Arakawa, Jassada Buaboonnam, Hui Zhang, Hsi-Che Liu, Hany Ariffin, Zhiwei Chen, Shirley K.Y. Kham, Rina Nishii, Daisuke Hasegawa, Junya Fujimura, Dai Keino, Kensuke Kondoh, Atsushi Sato, Takahiro Ueda, Masaki Yamamoto, Yuichi Taneyama, Moeko Hino, Masatoshi Takagi, Akira Ohara, Etsuro Ito, Katsuyoshi Koh, Hiroki Hori, Atsushi Manabe, Jun J. Yang, Motohiro Kato

https://doi.org/10.3324/haematol.2020.266320

Jan 21, 2021

Review Articles

Latest culture techniques: cracking the secrets of bone marrow to mass-produce erythrocytes and platelets ex vivo

Christian A. Di Buduo, Alicia Aguilar, Paolo M. Soprano, Alberto Bocconi, Carolina P. Miguel, Giovanna Mantica, Alessandra Balduini

https://doi.org/10.3324/haematol.2020.262485

Articles

Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation

Michela Faleschini, Nicole Papa, Marie-Christine Morel-Kopp, Caterina Marconi, Tania Giangregorio, Federica Melazzini, Valeria Bozzi, Marco Seri, Patrizia Noris, Alessandro Pecci, Anna Savoia, Roberta Bottega

https://doi.org/10.3324/haematol.2020.267328

Letters to the Editor

Jan 14, 2021

Articles

Long term follow-up of pediatric-onset Evans syndrome: broad immunopathological manifestations and high treatment burden

Thomas Pincez, Helder Fernandes, Thierry Leblanc, Gérard Michel, Vincent Barlogis, Yves Bertrand, Bénédicte Neven, Wadih Abou Chahla, Marlène Pasquet, Corinne Guitton, Aude Marie-Cardine, Isabelle Pellier, Corinne Armari-Alla, Joy Benadiba, Pascale Blouin, Eric Jeziorski, Frédéric Millot, Catherine Paillard, Caroline Thomas, Nathalie Cheikh, Sophie Bayart, Fanny Fouyssac, Christophe Piguet, Marianna Deparis, Claire Briandet, Eric Dore, Capucine Picard, Frédéric Rieux-Laucat, Judith Landman-Parker, Guy Leverger, Nathalie Aladjidi

https://doi.org/10.3324/haematol.2020.271106

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity

Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger

https://doi.org/10.3324/haematol.2020.269670

Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector

Yang Liu, Maria Dahl, Shubhranshu Debnath, Michael Rothe, Emma M. Smith, Tan Hooi Min Grahn, Sarah Warsi, Jun Chen, Johan Flygare, Axel Schambach, Stefan Karlsson

https://doi.org/10.3324/haematol.2020.269142

Human invariant natural killer T cells promote tolerance by preferential apoptosis induction of conventional dendritic cells

Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind

https://doi.org/10.3324/haematol.2020.267583

Letters to the Editor

Comparison of CD38 antibodies in vitro and ex vivo mechanisms of action in multiple myeloma

Michelle Kinder, Nizar J. Bahlis, Fabio Malavasi, Bart de Goeij, Alexander Babich, Jocelyn Sendecki, Joshua Rusbuldt, Kevin Bellew, Colleen Kane, Niels W.C.J. van de Donk

https://doi.org/10.3324/haematol.2020.268656

Jan 7, 2021

Articles

Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multicentre nation-wide cohort

Maddalena Casale, Gian Luca Forni, Elena Cassinerio, Daniela Pasquali, Raffaella Origa, Marilena Serra, Saveria Campisi, Angelo Peluso, Roberta Renni, Alessandro Cattoni, Elisa De Michele, Massimo Allò, Maurizio Poggi, Francesca Ferrara, Rosanna Di Concilio, Filomena Sportelli, Antonella Quarta, Maria Caterina Putti, Lucia Dora Notarangelo, Antonella Sau, Saverio Ladogana, Immacolata Tartaglione, Stefania Picariello, Alessia Marcon, Patrizia Sturiale, Domenico Roberti, Antonio Ivan Lazzarino, Silverio Perrotta

https://doi.org/10.3324/haematol.2020.272419

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia.

Rudy Birsen, Clement Larrue, Justine Decroocq, Natacha Johnson, Nathan Guiraud, Mathilde Gotanegre, Lilia Cantero-Aguilar, Eric Grignano, Tony Huynh, Michaela Fontenay, Olivier Kosmider, Patrick Mayeux, Nicolas Chapuis, Jean Emmanuel Sarry, Jerome Tamburini, Didier Bouscary

https://doi.org/10.3324/haematol.2020.259531

Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance

Martina Moras, Claude Hattab, Pedro Gonzalez-Menendez, Claudio M. Fader, Michael Dussiot, Jerome Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi Taylor, Sophie D. Lefevre, Mariano A. Ostuni

https://doi.org/10.3324/haematol.2020.257121

Dec 30, 2020

Articles

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide.

Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer

https://doi.org/10.3324/haematol.2020.271908

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis

Thomas Milan, Magalie Celton, Karine Lagacé, Élodie Roques, Safia Safa-Tahar-Henni, Eva Bresson, Anne Bergeron, Josée Hebert, Soheil Meshinchi, Sonia Cellot, Frédéric Barabé, Brian T Wilhelm

https://doi.org/10.3324/haematol.2020.271619

Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia

Anna Hecht, Julia A. Meyer, Astrid Behnert, Eric Wong, Farid Chehab, Adam Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat, Jason E. Farrar, Mark Fluchel, Haydar Frangoul, Jennifer H. Han, Edward A. Kolb, Dennis J. Kuo, Margaret L. MacMillan, Luke Maese, Kelly W. Maloney, Aru Narendran, Benjamin Oshrine, Kirk R. Schultz, Maria L. Sulis, David Van Mater, Sarah K. Tasian, Wolf-Karsten Hofmann, Mignon L. Loh, Elliot Stieglitz

https://doi.org/10.3324/haematol.2020.270595

Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia

Alisa Damnernsawad, Daniel Bottomly, Stephen E. Kurtz, Christopher A. Eide, Shannon K. McWeeney, Jeffrey W. Tyner, Tamilla Nechiporuk

https://doi.org/10.3324/haematol.2020.257964

Letters to the Editor

Glenzocimab does not impact glycoprotein VI-dependent inflammatory haemostasis

Soumaya Jadoui, Ophélie Le Chapelain, Véronique Ollivier, Ali Mostefa-Kara, Lucas Di Meglio, Sébastien Dupont, Angèle Gros, Mialitiana Solo Nomenjanahary, Jean-Philippe Desilles, Mikaël Mazighi, Bernhard Nieswandt, Stéphane Loyau, Martine Jandrot-Perrus, Pierre H Mangin, Benoit Ho-Tin-Noé

https://doi.org/10.3324/haematol.2020.270439

Immunophenotypic changes of leukemic blasts in children with relapsed/refractory B-cell precursor acute lymphoblastic leukemia, who have been treated with Blinatumomab

Ekaterina Mikhailova, Evgeny Gluhanyuk, Olga Illarionova, Elena Zerkalenkova, Svetlana Kashpor, Natalia Miakova, Yulia Diakonova, Yulia Olshanskaya, Larisa Shelikhova, Galina Novichkova, Michael Maschan, Alexey Maschan, Alexander Popov

https://doi.org/10.3324/haematol.2019.241596

Dec 23, 2020

Articles

Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and resensitizes acute myeloid leukemia to BCL-2 inhibition

Bing Z. Carter, Po Yee Mak, Wenjing Tao, Marc Warmoes, Philip L. Lorenzi, Duncan Mak, Vivian Ruvolo, Lin Tan, Justin Cidado, Lisa Drew, Michael Andreeff

https://doi.org/10.3324/haematol.2020.260331

Letters to the Editor

Genome wide association study of silent cerebral infarction in sickle cell disease (HbSS and HbSC)

John N. Brewin, Helen Rooks, Kate Gardner, Harry Senior, Mrinmayi Morje, Hamel Patel, David Calvet, Pablo Bartolucci, Swee-Lay Thein, Stephan Menzel, David C. Rees

https://doi.org/10.3324/haematol.2020.265827

Dec 17, 2020

Articles

Baseline SUVmax is related to tumor cell proliferation and patient outcome in follicular lymphoma

Cédric Rossi, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, Don-Marc Franchini, Nadia Amara, Charlotte Syrykh, Pierre Bories, Lucie Oberic, Loïc Ysebaert, Laurent Martin, Selim Ramla, Philippine Robert, Claire Tabouret-Viaud, René-Olivier Casasnovas, Jean-Jacques Fournié, Christine Bezombes, Camille Laurent

https://doi.org/10.3324/haematol.2020.263194

Post-translational polymodification of β1-tubulin regulates motor protein localisation in platelet production and function

Abdullah O. Khan, Alexandre Slater, Annabel Maclachlan, Phillip L.R. Nicolson, Jeremy A. Pike, Jasmeet S. Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G. Thomas, Neil V. Morgan

https://doi.org/10.3324/haematol.2020.270793

Letters to the Editor

Mixed-lineage leukemia protein modulates the loading of let-7a onto AGO1 by recruiting RAN

Shouhai Zhu, Zhihong Chen, Dan Jiang, Ruiheng Wang, Xiaoyan Cheng, Dan Li, Qiongyu Xv, Fei Zhao, Wootae Kim, Guijie Guo, Chunjun Zhao, Zhenkun Lou, Han Liu

https://doi.org/10.3324/haematol.2020.268474

Immunologic characterization of COVID-19 patients with hematological cancer

Catarina Maia, Esperanza Martín-Sánchez, Juan José Garcés, Ascensión López-Díaz de Cerio, Susana Inogés, Manuel F. Landecho, Belén Gil-Alzugaray, Cristina Perez, Cirino Botta, Aintzane Zabaleta, Félix Alegre, César Rincón, Laura Blanco, Sarai Sarvide, Amaia Vilas-Zornoza, Diego Alignani, Cristina Moreno, Artur Paiva, António Martinho, Rui Alves, Enrique Colado, Covadonga Quirós, Mónica Olid, Andrés Blanco, Josepmaria Argemi, Bruno Paiva, José Ramón Yuste

https://doi.org/10.3324/haematol.2020.269878

Case Reports

Biallelic IARS2 mutations presenting as sideroblastic anemia

Giulia Barcia, Dinusha Pandithan, Benedetta Ruzzenente, Zahra Assouline, Alessandra Pennisi, Clothilde Ormieres, Claude Besmond, Charles-Joris Roux, Nathalie Boddaert, Isabelle Desguerre, David R. Thorburn, Drago Bratkovic, Arnold Munnich, Jean-Paul Bonnefont, Agnès Rötig, Julie Steffann

https://doi.org/10.3324/haematol.2020.270710

Dec 10, 2020

Articles

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway

Tongjie Wang, Chengxiang Xia, Qitong Weng, Kaitao Wang, Yong Dong, Sha Hao, Fang Dong, Xiaofei Liu, Lijuan Liu, Yang Geng, Yuxian Guan, Juan Du, Tao Cheng, Hui Cheng, Jinyong Wang

https://doi.org/10.3324/haematol.2019.239186

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia

Alaeddin Khalil, Gudrun Würthwein, Jana Golitsch, Georg Hempel, Manfred Fobker, Joachim Gerss, Anja Möricke, Martin Zimmermann, Petr Smisek, Massimo Zucchetti, Christa Nath, Andishe Attarbaschi, Arend von Stackelberg, Nicola Gökbuget, Carmelo Rizzari, Valentino Conter, Martin Schrappe, Joachim Boos, Claudia Lanvers-Kaminsky

https://doi.org/10.3324/haematol.2020.258525

Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential

Lennart Raman, Malaïka Van der Linden, Ciel De Vriendt, Bliede Van den Broeck, Kristoff Muylle, Dries Deeren, Franceska Dedeurwaerdere, Sofie Verbeke, Amélie Dendooven, Katrien De Grove, Saskia Baert, Kathleen Claes, Björn Menten, Fritz Offner, Jo Van Dorpe

https://doi.org/10.3324/haematol.2020.268813

Letters to the Editor

Minimal residual disease monitoring in acute myeloid leukemia with non-A/B/D-NPM1 mutations by digital polymerase chain reaction: feasibility and clinical use

Auriane Lesieur, Xavier Thomas, Olivier Nibourel, Nicolas Boissel, Laurène Fenwarth, Stéphane De Botton, Elise Fournier, Karine Celli-Lebras, Emmanuel Raffoux, Christian Recher, Juliette Lambert, Céline Berthon, Arnaud Pigneux, Raphael Itzykson, Pascal Turlure, Cécile Pautas, Jacques Vargaftig, Claude Preudhomme, Hervé Dombret, Nicolas Duployez

https://doi.org/10.3324/haematol.2020.260133

Dec 3, 2020

Editorials
Article

Impact of luteinizing hormone suppression on hematopoietic recovery after intensive chemotherapy in patients with leukemia

Iman Abou Dalle, Ronald Paranal, Jabra Zarka, Shilpa Paul, Koji Sasaki, Wen Li, Jing Ning, Nicholas J. Short, Maro Ohanian, Jorge E. Cortes, Elias J. Jabbour, Ghayas C. Issa

https://doi.org/10.3324/haematol.2020.256453

Articles

Phenogenomic heterogeneity of post-transplant plasmablastic lymphomas

Rebecca J. Leeman-Neill, Craig R. Soderquist, Francesca Montanari, Patricia Raciti, David Park, Dejan Radeski, Mahesh M. Mansukhani, Vundavalli V. Murty, Susan Hsiao, Bachir Alobeid, Govind Bhagat

https://doi.org/10.3324/haematol.2020.267294

Autologous stem cell transplantation is safe and effective for fit older myeloma patients: exploratory results from the Myeloma XI trial

Charlotte Pawlyn, David Cairns, Tom Menzies, John Jones, Matthew Jenner, Gordon Cook, Kevin Boyd, Mark Drayson, Martin Kaiser, Roger Owen, Walter Gregory, Gareth Morgan, Graham Jackson, Faith Davies

https://doi.org/10.3324/haematol.2020.262360

Nov 26, 2020

Review Articles

Articles

Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis

Sheila Bohler, Sehar Afreen, Juncal Fernandez-Orth, Eva-Maria Demmerath, Christian Molnar, Ying Wu, Julia Miriam Weiss, Venugopal Rao Mittapalli, Lukas Konstantinidis, Hagen Schmal, Mirjam Kunze, Miriam Erlacher

https://doi.org/10.3324/haematol.2020.252130

The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion

Audrey Astori, Gabriel Matherat, Isabelle Munoz, Emilie-Fleur Gautier, Didier Surdez, Yaël Zermati, Frédérique Verdier, Sakina Zaidi, Vincent Feuillet, Amir Kadi, Evelyne Lauret, Olivier Delattre, Carine Lefèvre, Michaela Fontenay, Evelyne Ségal-Bendirdjian, Isabelle Dusanter-Fourt, Didier Bouscary, Olivier Hermine, Patrick Mayeux, Frédéric Pendino

https://doi.org/10.3324/haematol.2020.263558

Nov 19, 2020

Articles

Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells

Sandra Romero Marquez, Franziska Hettler, Renate Hausinger, Christina Schreck, Theresa Landspersky, Lynette Henkel, Corinne Angerpointner, Ihsan E. Demir, Matthias Schiemann, Florian Bassermann, Katharina S. Götze, Rouzanna Istvánffy, Robert A.J. Oostendorp

https://doi.org/10.3324/haematol.2020.249102

Bone marrow megakaryocytic activation predicts fibrotic evolution of Philadelphia-negative myeloproliferative neoplasms

Mattia Schino, Vincenzo Fiorentino, Elena Rossi, Silvia Betti, Monica Di Cecca, Valentina Ranucci, Patrizia Chiusolo, Maurizio Martini, Valerio De Stefano, Luigi Maria Larocca

https://doi.org/10.3324/haematol.2020.264143

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways

Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling

https://doi.org/10.3324/haematol.2020.267500

Letters to the Editor

Quantitative PCR-based chimerism in bone marrow or peripheral blood to predict acute myeloid leukemia relapse in high-risk patients: results from the KIM-PB prospective study

Valentina Gambacorta, Riccardo Parolini, Elisabetta Xue, Raffaella Greco, Evelien E. Bouwmans, Cristina Toffalori, Fabio Giglio, Andrea Assanelli, Maria Teresa Lupo Stanghellini, Alessandro Ambrosi, Benedetta Mazzi, Wietse Mulder, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri, Luca Vago

https://doi.org/10.3324/haematol.2019.238543

Nov 12, 2020

Articles

A prognostic index predicting survival in transformed Waldenström macroglobulinemia

Eric Durot, Lukshe Kanagaratnam, Saurabh Zanwar, Efstathios Kastritis, Shirley D’Sa, Ramon Garcia-Sanz, Cécile Tomowiak, Bénédicte Hivert, Elise Toussaint, Caroline Protin, Jithma P. Abeykoon, Thomas Guerrero-Garcia, Gilad Itchaki, Josephine M. Vos, Anne-Sophie Michallet, Sophie Godet, Jehan Dupuis, Stéphane Leprêtre, Joshua Bomsztyk, Pierre Morel, Véronique Leblond, Steven P. Treon, Meletios A. Dimopoulos, Prashant Kapoor, Alain Delmer, Jorge J. Castillo

https://doi.org/10.3324/haematol.2020.262899

Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project

Claudia Sargas, Rosa Ayala, María Carmen Chillón, María J. Larráyoz, Estrella Carrillo-Cruz, Cristina Bilbao, Manuel Yébenes-Ramírez, Marta Llop, Inmaculada Rapado, Ramón García-Sanz, Iria Vázquez, Elena Soria, Yanira Florido-Ortega, Kamila Janusz, Carmen Botella, Josefina Serrano, David Martínez-Cuadrón, Juan Bergua, Mari Luz Amigo, Pilar Martínez-Sánchez, Mar Tormo, Teresa Bernal, Pilar Herrera-Puente, Raimundo García, Lorenzo Algarra, María J. Sayas, Lisette Costilla-Barriga, Esther Pérez-Santolalla, Inmaculada Marchante, Esperanza Lavilla-Rubira, Víctor Noriega, Juan M. Alonso-Domínguez, Miguel Á. Sanz, Joaquín Sánchez-Garcia, María T. Gómez-Casares, José A. Pérez-Simón, María J. Calasanz, Marcos González-Díaz, Joaquín Martínez-López, Eva Barragán, Pau Montesinos

https://doi.org/10.3324/haematol.2020.263806

Letters to the Editor

Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance

Stine U. Mikkelsen, Setareh Safavi, Konstantinos Dimopoulos, Colm J. O’Rourke, Mette K. Andersen, Mette S. Holm, Claus W. Marcher, Jesper B. Andersen, Jakob W. Hansen, Kirsten Grønbæk

https://doi.org/10.3324/haematol.2020.263319

Rapid decline in estimated glomerular filtration rate in sickle cell anemia: results of a multicenter pooled analysis

Kenneth I. Ataga, Qingning Zhou, Vimal K. Derebail, Santosh L. Saraf, Jane S. Hankins, Laura R. Loehr, Melanie E. Garrett, Allison E. Ashley-Koch, Jianwen Cai, Marilyn J. Telen

https://doi.org/10.3324/haematol.2020.267419

Homozygous Southeast Asian ovalocytosis in five live-born neonates

Amanda A. Lavinya, Ruzzieatul A. Razali, Munirah A. Razak, Rashidah Mohamed, Emmanuel J. Moses, Meera Soundararajan, Lesley J. Bruce, Jeyanthy Eswaran, Narazah Mohd Yusoff

https://doi.org/10.3324/haematol.2020.268581

Nov 5, 2020

Articles

PVRIG is a novel NK cell immune checkpoint receptor in acute myeloid leukemia

Jessica Li, Sarah Whelan, Maya F. Kotturi, Deborah Meyran, Criselle D’Souza, Kyle Hansen, Spencer Liang, John Hunter, Joseph A. Trapani, Paul J. Neeson

https://doi.org/10.3324/haematol.2020.258574

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Željko Antić, Jiangyan Yu, Simon V. van Reijmersdal, Anke van Dijk, Linde Dekker, Wouter H. Segerink, Edwin Sonneveld, Marta Fiocco, Rob Pieters, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Ad Geurts van Kessel, Esme Waanders, Roland P. Kuiper

https://doi.org/10.3324/haematol.2020.259226

Phase I study of selinexor in combination with dexamethasone, ifosfamide, carboplatin, etoposide chemotherapy in patients with relapsed or refractory peripheral T-cell or naturalkiller/T-cell lymphoma

Tiffany Tang, Peter Martin, Nagavalli Somasundaram, Cindy Lim, Miriam Tao, Eileen Poon, Maica JD. Yunon, Shu Q. Toh, Sean X Yan, Mohamad Farid, Jason Y. Chan, Soon T. Lim

https://doi.org/10.3324/haematol.2020.251454

Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo

Mara N. Zeissig, Duncan R. Hewett, Vasilios Panagopoulos, Krzysztof M. Mrozik, L. Bik To, Peter I. Croucher, Andrew C.W. Zannettino, Kate Vandyke

https://doi.org/10.3324/haematol.2020.253526

Letters to the Editor

Serum monoclonal component in chronic lymphocytic leukemia: baseline correlations and prognostic impact

Pablo Mozas, Juan A. Pineyroa, Ferran Nadeu, Laura Magnano, Andrea Rivero, Alfredo Rivas-Delgado, Alex Bataller, Aleix Fabregat, Eva Gine, Tycho Baumann, Neus Villamor, Juan Ignacio Arostegui, Marta Aymerich, Armando Lopez-Guillermo, Elias Campo, Julio Delgado

https://doi.org/10.3324/haematol.2020.263228

Oct 29, 2020

Articles

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities

Caroline Scott, Damien J. Downes, Jill M. Brown, Robert Beagrie, Aude-Anais Olijnik, Matthew Gosden, Ron Schwessinger, Christopher A. Fisher, Anna Rose, David J.P Ferguson, Errin Johnson, Quentin A. Hill, Steven Okoli, Raffaele Renella, Kate Ryan, Marjorie Brand, Jim Hughes, Noemi B.A. Roy, Douglas R. Higgs, Christian Babbs, Veronica J. Buckle

https://doi.org/10.3324/haematol.2020.260158

Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria

Antonio M. Risitano, Austin G. Kulasekararaj, Jong Wook Lee, Jaroslaw P. Maciejewski, Rosario Notaro, Robert Brodsky, Mingjun Huang, Michael Geffner, Peter Browett

https://doi.org/10.3324/haematol.2020.261826

Use of the HLA-B leader to optimize cord-blood transplantation

Effie W. Petersdorf, Ted Gooley, Fernanda Volt, Chantal Kenzey, Alejandro Madrigal, Caroline McKallor, Sergio Querol, Hanadi Rafii, Vanderson Rocha, Ryad Tamouza, Christian Chabannon, Annalisa Ruggeri, Eliane Gluckman

https://doi.org/10.3324/haematol.2020.264424

Venetoclax plus bendamustine-rituximab or bendamustine-obinutuzumab in chronic lymphocytic leukemia: final results of a phase 1b study (GO28440)

Stephan Stilgenbauer, Franck Morschhauser, Clemens-Martin Wendtner, Guillaume Cartron, Michael Hallek, Barbara Eichhorst, Mark F. Kozloff, Thomas Giever, Gerard Lozanski, Yanwen Jiang, Huang Huang, Daniela Soriano Pignataro, William Schary, Kathryn Humphrey, Mehrdad Mobasher, Gilles Salles

https://doi.org/10.3324/haematol.2020.261107

SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation

Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei

https://doi.org/10.3324/haematol.2020.261891

Letters to the Editor

Pituitary iron and factors predictive of fertility status in transfusion dependent thalassemia

Sylvia T. Singer, Roland Fischer, Isabel Allen, Ashutosh Lal, Elliott Vichinsky, Qing Yuan, Zhiyue J Wang

https://doi.org/10.3324/haematol.2020.252726

Antimicrobial resistance is a risk factor for mortality in adults with sickle cell disease

Andrew Srisuwananukorn, Jin Han, Rasha Raslan, Michel Gowhari, Faiz Hussain, Franklin Njoku, Robert E Molokie, Victor R. Gordeuk, Santosh L. Saraf

https://doi.org/10.3324/haematol.2020.267872

Case Reports

Unusual survival of a twin with homozygous α0-thalassemia due to chimerism

Dejian Pang, Xuan Shang, Decheng Cai, Fang Yang, Huijie Lu, Yi Cheng, Xiaofeng Wei, Fei He, Xiangmin Xu

https://doi.org/10.3324/haematol.2020.262600

Oct 13, 2020

Articles

Zanubrutinib monotherapy for patients with treatment naïve chronic lymphocytic leukemia and 17p deletion

Constantine S. Tam, Tadeusz Robak, Paolo Ghia, Brad S. Kahl, Patricia Walker, Wojciech Janowski, David Simpson, Mazyar Shadman, Peter S. Ganly, Luca Laurenti, Stephen Opat, Monica Tani, Hanna Ciepluch, Emma Verner, Martin Šimkovič, Anders Österborg, Marek Trněný, Alessandra Tedeschi, Jason C. Paik, Sowmya B. Kuwahara, Shibao Feng, Vanitha Ramakrishnan, Aileen Cohen, Jane Huang, Peter Hillmen, Jennifer R. Brown

https://doi.org/10.3324/haematol.2020.259432

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice

Manfred Nairz, Christoph Metzendorf, Maja Vujic-Spasic, Anna-Maria Mitterstiller, Andrea Schroll, David Haschka, Alexander Hoffmann, Laura von Raffay, Richard Sparla, Christian W. Huck, Heribert Talasz, Patrizia L. Moser, Martina U. Muckenthaler, Günter Weiss

https://doi.org/10.3324/haematol.2019.241745

Pediatric-inspired chemotherapy incorporating pegaspargase is safe and results in high rates of minimal residual disease negativity in adults up to age 60 with Philadelphia chromosome-negative acute lymphoblastic leukemia

Mark B. Geyer, Ellen K. Ritchie, Arati V. Rao, Shreya Vemuri, Jessica Flynn, Meier Hsu, Sean M. Devlin, Mikhail Roshal, Qi Gao, Madhulika Shukla, Jose M. Salcedo, Peter Maslak, Martin S. Tallman, Dan Douer, Jae H. Park

https://doi.org/10.3324/haematol.2020.251686

Plasmacytoid dendritic cells proliferation associated with acute myeloid leukemia: phenotype profile and mutation landscape

Loria Zalmaï, Pierre-Julien Viailly, Sabeha Biichle, Meyling Cheok, Lou Soret, Fanny Angelot-Delettre, Tony Petrella, Marie-Agnès Collonge-Rame, Estelle Seilles, Sandrine Geffroy, Eric Deconinck, Etienne Daguindau, Sabrina Bouyer, Elodie Dindinaud, Victor Baunin, Magali Le Garff-Tavernier, Damien Roos-Weil, Orianne Wagner-Ballon, Véronique Salaun, Jean Feuillard, Sophie Brun, Bernard Drenou, Caroline Mayeur-Rousse, Patricia Okamba, Véronique Dorvaux, Michel Tichionni, Johann Rose, Marie Thérèse Rubio, Marie Christine Jacob, Victoria Raggueneau, Claude Preudhomme, Philippe Saas, Christophe Ferrand, Olivier Adotevi, Christophe Roumier, Fabrice Jardin, Francine Garnache-Ottou, Florian Renosi

https://doi.org/10.3324/haematol.2020.253740

Letters to the Editor

The survival impact of maintenance lenalidomide: an analysis of real-world data from the Canadian Myeloma Research Group national database

Hannah M. Cherniawsky, Vishal Kukreti, Donna Reece, Esther Masih-Khan, Arleigh McCurdy, Victor H. Jimenez-Zepeda, Michael Sebag, Kevin Song, Darrell White, Julie Stakiw, Richard LeBlanc, Anthony Reiman, Muhammad Aslam, Martha Louzada, Rami Kotb, Engin Gul, Eshetu Atenafu, Christopher P. Venner

https://doi.org/10.3324/haematol.2020.259093

No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma

Shin Yeu Ong, Jing Quan Lim, Nicholas Grigoropoulos, Yurike Laurensia, Dachuan Huang, Burton Kuan Hui Chia, Daryl Cheah Ming Zhe, Sahil Ajit Saraf, Chee Leong Cheng, Wen-Yu Chuang, Ming-Chung Kuo, Yi-Jiun Su, Colin Phipps, Chandramouli Nagarajan, Yuh Shan Lee, Daryl Tan Chen Lung, Lee-Yung Shih, Yeow Tee Goh, Soon Thye Lim, Choon Kiat Ong

https://doi.org/10.3324/haematol.2020.269209

Oct 5, 2020

Articles

Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans

Daniel C.J. Ferguson, Juraidah Haji Mokim, Marjolein Meinders, Edmund R.R. Moody, Tom A. Williams, Sarah Cooke, Kongtana Trakarnsanga, Deborah E. Daniels, Ivan Ferrer-Vicens, Deborah Shoemark, Chartsiam Tipgomut, Katherine A. Macinnes, Marieangela C. Wilson, Belinda K. Singleton, Jan Frayne

https://doi.org/10.3324/haematol.2020.256347

Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration

Deborah M. Stephens, Ken Boucher, Elizabeth Kander, Sameer A. Parikh, Erin M. Parry, Mazyar Shadman, John M. Pagel, Jennifer Cooperrider, Joanna Rhodes, Anthony Mato, Allison Winter, Brian Hill, Sameh Gaballa, Alexey Danilov, Tycel Phillips, Danielle M. Brander, Sonali M. Smith, Matthew Davids, Kerry Rogers, Martha J. Glenn, John C. Byrd

https://doi.org/10.3324/haematol.2020.256388

Letters to the Editor

Modulated expression of adhesion, migration and activation molecules may predict the degree of response in chronic lymphocytic leukemia patients treated with ibrutinib plus rituximab

Nadia Peragine, Maria Stefania De Propris, Stefania Intoppa, Maria Laura Milani, Paola Mariglia, Francesca Romana Mauro, Sara Raponi, Stefano Soddu, Antonio Cuneo, Gian Matteo Rigolin, Ilaria Del Giudice, Robin Foà, Anna Guarini

https://doi.org/10.3324/haematol.2020.262071

Standardization of flow cytometric minimal residual disease assessment in international clinical trials - a feasibility study from the European Myeloma Network

Davine Hofste op Bruinink, Stefania Oliva, Lucie Rihova, Alexander Schmitz, Milena Gilestro, Jeroen te Marvelde, Romana Kralova, Helle Høholt, Annemiek Broijl, Hans Erik Johnsen, Roman Hajek, Mario Boccadoro, Pieter Sonneveld, Paola Omedè, Vincent H.J. van der Velden

https://doi.org/10.3324/haematol.2020.267831

Sep 28, 2020

Articles

Engineered type 1 regulatory T cells designed for clinical use kill primary pediatric acute myeloid leukemia cells

Brandon Cieniewicz, Molly Javier Uyeda, Ping (Pauline) Chen, Ece Canan Sayitoglu, Jeffrey Mao-Hwa Liu, Grazia Andolfi, Katharine Greenthal, Alice Bertaina, Silvia Gregori, Rosa Bacchetta, Norman James Lacayo, Alma-Martina Cepika, Maria Grazia Roncarolo

https://doi.org/10.3324/haematol.2020.263129

Platelet proteome and function in X–linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome

Daniel Bergemalm, Sofia Ramström, Caroline Kardeby, Kjell Hultenby, Anna Göthlin Eremo, Carina Sihlbom, Jörgen Bergström, Jan Palmblad, Maria Åström

https://doi.org/10.3324/haematol.2020.249805

Letters to the Editor

Benefit of intermediate-dose cytarabine containing induction in molecular subgroups of acute myeloid leukemia

Hui Wei, Chunlin Zhou, Dong Lin, Bingcheng Liu, Yan Li, Xingli Zhao, Shuning Wei, Benfa Gong, Kaiqi Liu, Xiaoyuan Gong, Yuntao Liu, Guangji Zhang, Jiayuan Chen, Junping Zhang, Jingjing Jin, Shaowei Qiu, Runxia Gu, Ying Wang, Yingchang Mi, Jianxiang Wang

https://doi.org/10.3324/haematol.2020.267526

Case Reports

Pathogenetic and clinical study of a patient with thrombocytopenia due to the p.E527K gain-of-function variant of SRC

Serena Barozzi, Christian A. Di Buduo, Caterina Marconi, Valeria Bozzi, Marco Seri, Francesca Romano, Alessandra Balduini, Alessandro Pecci

https://doi.org/10.3324/haematol.2020.268516

Sep 21, 2020

Articles

Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro

Thomas Hoefer, Akshita Rana, Be'eri Niego, Shweta Jagdale, Hugo J. Albers, Elizabeth E. Gardiner, Robert K. Andrews, Andries D. Van der Meer, Christoph E. Hagemeyer, Erik Westein

https://doi.org/10.3324/haematol.2020.250761

Sep 14, 2020

Articles

Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma

Youssef Youssef, Vrajesh Karkhanis, Wing Keung Chan, Frankie Jeney, Alessandro Canella, Xiaoli Zhang, Shelby Sloan, Alexander Prouty, JoBeth Helmig-Mason, Liudmyla Tsyba, Walter Hanel, Xuguang Zheng, Pu Zhang, Ji-Hyun Chung, David M. Lucas, Zachary Kauffman, Karilyn Larkin, Anne M. Strohecker, Hatice G. Ozer, Rosa Lapalombella, Hui Zhou, Zijun Y. Xu-Monette, Ken H. Young, Ruolan Han, Elmar Nurmemmedov, Gerard Nuovo, Kami Maddocks, John C. Byrd, Robert A. Baiocchi, Lapo Alinari

https://doi.org/10.3324/haematol.2020.268235

The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis

Mahran Shoukier, Gautam Borthakur, Elias Jabbour, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Jairo Matthews, Lucia Masarova, Kiran Naqvi, Koji Sasaki, Srdan Verstovsek, Jorge Cortes

https://doi.org/10.3324/haematol.2020.260125

Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations

Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak

https://doi.org/10.3324/haematol.2020.254193

Intravenous iron preparations transiently generate non-transferrin-bound iron from two proposed pathways

Maciej W. Garbowski, Sukhvinder Bansal, John B. Porter, Claudio Mori, Susanna Burckhardt, Robert C. Hider

https://doi.org/10.3324/haematol.2020.250803

Letters to the Editor

Very low incidence of Clostridioides difficile infection in pediatric sickle cell disease patients

Philip Lee, Arpan A. Sinha, Vijaya L. Soma, Carlos Cruz, Tao Wang, Olga Aroniadis, Betsy C. Herold, Paul S. Frenette, David L. Goldman, Deepa Manwani

https://doi.org/10.3324/haematol.2019.244582

Sep 10, 2020

Articles

CDKN2A deletion is a frequent event associated with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS)

Francesco Maura, Anna Dodero, Cristiana Carniti, Niccolò Bolli, Martina Magni, Valentina Monti, Antonello Cabras, Daniel Leongamornlert, Federico Abascal, Benjamin Diamond, Bernardo Rodriguez-Martin, Jorge Zamora, Adam Butler, Inigo Martincorena, Jose M. C. Tubio, Peter J. Campbell, Annalisa Chiappella, Giancarlo Pruneri, Paolo Corradini

https://doi.org/10.3324/haematol.2020.262659

Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells

Angelo D’Alessandro, Ariel Hay, Monika Dzieciatkowska, Benjamin C. Brown, Evan J Morrison, Kirk C. Hansen, James C Zimring

https://doi.org/10.3324/haematol.2020.266676

Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency

Birgit van Dooijeweert, Melissa H. Broeks, Nanda M. Verhoeven-Duif, Eduard J. van Beers, Edward E.S. Nieuwenhuis, Wouter W. van Solinge, Marije Bartels, Judith J. Jans, Richard van Wijk

https://doi.org/10.3324/haematol.2020.266957

Letters to the Editor

Quantitative PCR-based chimerism in bone marrow or peripheral blood to predict acute myeloid leukemia relapse in high-risk patients: results from the KIM-PB prospective study

Valentina Gambacorta, Riccardo Parolini, Elisabetta Xue, Raffaella Greco, Evelien E. Bouwmans, Cristina Toffalori, Fabio Giglio, Andrea Assanelli, Maria Teresa Lupo Stanghellini, Alessandro Ambrosi, Benedetta Mazzi, Wietse Mulder, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri, Luca Vago

https://doi.org/10.3324/haematol.2019.238543

Exosomes-driven lipolysis and bone marrow niche remodeling supports leukemia expansion

Bijender Kumar, Marvin Orellana, Jamison Brooks, Srideshikan Sargur Madabushi, Paresh Vishwasrao, Liliana E. Parra, James Sanchez, Amandeep Salhotra, Anthony Stein, Ching-Cheng Chen, Guido Marcucci, Susanta Kumar Hui

https://doi.org/10.3324/haematol.2019.246058

Aug 27, 2020

Articles

Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype

Antonio Vogelsberg, Julia Steinhilber, Barbara Mankel, Birgit Federmann, Janine Schmidt, Ivonne A. Montes-Mojarro, Katrin Hüttl, Maria Rodriguez-Pinilla, Praveen Baskaran, Sven Nahnsen, Miguel A. Piris, German Ott, Leticia Quintanilla-Martinez, Irina Bonzheim, Falko Fend

https://doi.org/10.3324/haematol.2020.254854

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease

Sara El Hoss, Sylvie Cochet, Auria Godard, Hongxia Yan, Michaël Dussiot, Giacomo Frati, Bénédicte Boutonnat-Faucher, Sandrine Laurance, Olivier Renaud, Laure Joseph, Annarita Miccio, Valentine Brousse, Mohandas Narla, Wassim El Nemer

https://doi.org/10.3324/haematol.2020.265462

Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNFα, IL-6 and IL-11 cytokines

Paolo Giannoni, Cecilia Marini, Giovanna Cutrona, Serena Matis, Maria Cristina Capra, Francesca Puglisi, Paola Luzzi, Simona Pigozzi, Gabriele Gaggero, Antonino Neri, Katia Todoerti, Fortunato Morabito, Adalberto Ibatici, Maurizio Miglino, Micaela Bergamaschi, Silvia Bruno, Gian Mario Sambuceti, Jean Louis Ravetti, Manlio Ferrarini, Franco Fais, Daniela de Totero

https://doi.org/10.3324/haematol.2019.231456

Clinical significance of chromatin-spliceosome acute myeloid leukemia: a report from the Northern Italy Leukemia Group (NILG) randomized trial 02/06

Chiara Caprioli, Federico Lussana, Silvia Salmoiraghi, Roberta Cavagna, Ksenija Buklijas, Lara Elidi, Pamela Zanghi', Anna Michelato, Federica Delaini, Elena Oldani, Tamara Intermesoli, Anna Grassi, Giacomo Gianfaldoni, Francesco Mannelli, Dario Ferrero, Ernesta Audisio, Elisabetta Terruzzi, Lorella De Paoli, Chiara Cattaneo, Erika Borlenghi, Irene Cavattoni, Monica Tajana, Anna Maria Scattolin, Daniele Mattei, Paolo Corradini, Leonardo Campiotti, Fabio Ciceri, Massimo Bernardi, Elisabetta Todisco, Agostino Cortelezzi, Brunangelo Falini, Chiara Pavoni, Renato Bassan, Orietta Spinelli, Alessandro Rambaldi

https://doi.org/10.3324/haematol.2020.252825

Combinatorial molecule screening identifies a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells

Simon Hultmark, Aurélie Baudet, Ludwig Schmiderer, Pavan Prabhala, Sara Palma-Tortosa, Carl Sandén, Thoas Fioretos, Rajkumar Sasidharan, Christer Larsson, Sören Lehmann, Gunnar Juliusson, Fredrik Ek, Mattias Magnusson

https://doi.org/10.3324/haematol.2020.249177

Oxidative stress activates red cell adhesion to laminin in sickle cell disease

Maria Alejandra Lizarralde-Iragorri, Sophie D. Lefevre, Sylvie Cochet, Sara El Hoss, Valentine Brousse, Anne Filipe, Michael Dussiot, Slim Azouzi, Caroline Le Van Kim, Fernando Rodrigues-Lima, Olivier Français, Bruno Le Pioufle, Thomas Klei, Robin van Bruggen, Wassim El Nemer

https://doi.org/10.3324/haematol.2020.261586

Letters to the Editor

Hemostatic alterations in COVID-19

Flora Peyvandi, Andrea Artoni, Cristina Novembrino, Stefano Aliberti, Mauro Panigada, Marco Boscarino, Roberta Gualtierotti, Federica Rossi, Roberta Palla, Ida Martinelli, Giacomo Grasselli, Francesco Blasi, Armando Tripodi

https://doi.org/10.3324/haematol.2020.262634

How to implement endurance exercise training in sickle cell disease

Laurent A. Messonnier, Manon Riccetti, Benjamin Chatel, Frédéric Galactéros, Barnabas Gellen, Thomas Rupp, Léonard Féasson, Pablo Bartolucci

https://doi.org/10.3324/haematol.2020.267047

Aug 13, 2020

Articles

Efficacy, safety and immunological profile of combining rituximab with belimumab for adults with persistent or chronic immune thrombocytopenia: results from a prospective phase 2b trial

Matthieu Mahévas, Imane Azzaoui, Etienne Crickx, Florence Canoui-Poitrine, Delphine Gobert, Laetitia Languille, Nicolas Limal, Constance Guillaud, Laure Croisille, Mohamed Jeljeli, Fréderic Batteux, Samia Baloul, Olivier Fain, France Pirenne, Jean-Claude Weill, Claude-Agnès Reynaud, Bertrand Godeau, Marc Michel

https://doi.org/10.3324/haematol.2020.259481

A 3-gene signature based on MYC, BCL-2 and NFKBIA improves risk stratification in diffuse large B-cell lymphoma

Enrico Derenzini, Saveria Mazzara, Federica Melle, Giovanna Motta, Marco Fabbri, Riccardo Bruna, Claudio Agostinelli, Alessandra Cesano, Chiara Antonia Corsini, Ning Chen, Simona Righi, Elena Sabattini, Annalisa Chiappella, Angelica Calleri, Stefano Fiori, Valentina Tabanelli, Antonello Cabras, Giancarlo Pruneri, Umberto Vitolo, Alessandro Massimo Gianni, Alessandro Rambaldi, Paolo Corradini, Pier Luigi Zinzani, Corrado Tarella, Stefano Pileri

https://doi.org/10.3324/haematol.2019.236455

Letters to the Editor

Molecular attributes underlying central nervous system and systemic relapse in diffuse large B-cell lymphoma

Keren Isaev, Daisuke Ennishi, Laura Hilton, Brian Skinnider, Karen L. Mungall, Andrew J. Mungall, Mehran Bakhtiari, Rosemarie Tremblay-LeMay, Anjali Silva, Susana Ben-Neriah, Merrill Boyle, Diego Villa, Marco A. Marra, Christian Steidl, Randy D. Gascoyne, Ryan Morin, Kerry J. Savage, David W. Scott, Robert Kridel

https://doi.org/10.3324/haematol.2020.255950

The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia

Yun Zhou, Haiwei Lian, Ning Shen, Sovannarith Korm, Andrew Kwok Ping Lam, Olivia Layton, Leah N. Huiting, Dun Li, Kelly Miao, Aozhuo Zeng, Esther Landesman-Bollag, David C. Seldin, Hui Fu, Li Hong, Hui Feng

https://doi.org/10.3324/haematol.2020.246918

Gender-specific transcriptional profiles identified in β-thalassemia patients

Aikaterini Nanou, Chrisavgi Toumpeki, Pavlos Fanis, Nicoletta Bianchi, Lucia Carmela Cosenza, Cristina Zuccato, George Sentis, Giorgos Giagkas, Coralea Stephanou, Marios Phylactides, Soteroula Christou, Michalis Hadjigavriel, Maria Sitarou, Carsten W. Lederer, Roberto Gambari, Marina Kleanthous, Eleni Katsantoni

https://doi.org/10.3324/haematol.2020.248013

Jul 30, 2020

Articles

A pilot study of ruxolitinib as a front-line therapy for 12 children with secondary hemophagocytic lymphohistiocytosis

Qing Zhang, Ang Wei, Hong-Hao Ma, Li Zhang, Hong-Yun Lian, Dong Wang, Yun-Ze Zhao, Lei Cui, Wei-Jing Li, Ying Yang, Tian-You Wang, Zhi-Gang Li, Rui Zhang

https://doi.org/10.3324/haematol.2020.253781

Impaired nodal shrinkage and apoptosis define the independent adverse outcome of NOTCH1 mutated patients under ibrutinib therapy in chronic lymphocytic leukaemia

Giovanni Del Poeta, Annalisa Biagi, Luca Laurenti, Annalisa Chiarenza, Federico Pozzo, Idanna Innocenti, Massimiliano Postorino, Francesca Maria Rossi, Maria Ilaria Del Principe, Riccardo Bomben, Paolo de Fabritiis, Antonio Bruno, Maria Cantonetti, Francesco Di Raimondo, Antonella Zucchetto, Valter Gattei

https://doi.org/10.3324/haematol.2020.251488

3D co-culture model of chronic lymphocytic leukemia bone marrow microenvironment predicts patient-specific response to mobilizing agents

Federica Barbaglio, Daniela Belloni, Lydia Scarfò, Francesca Vittoria Sbrana, Maurilio Ponzoni, Lucia Bongiovanni, Luca Pavesi, Desiree Zambroni, Kostas Stamatopoulos, Valeria R. Caiolfa, Elisabetta Ferrero, Paolo Ghia, Cristina Scielzo

https://doi.org/10.3324/haematol.2020.248112

Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1

Gehong Dong, Yuping Li, Logan Lee, Xuxiang Liu, Yunfei Shi, Xiaoqian Liu, Alyssa Bouska, Qiang Gong, Lingbo Kong, Jinhui Wang, Chih-Hong Lou, Timothy W. McKeithan, Javeed Iqbal, Wing C. Chan

https://doi.org/10.3324/haematol.2020.254276

Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus

Petros Kountouris, Kyriaki Michailidou, Soteroula Christou, Michael Hadjigavriel, Maria Sitarou, Anita Kolnagou, Marina Kleanthous, Paul Telfer

https://doi.org/10.3324/haematol.2020.260224

MYB bi-allelic targeting abrogates primitive clonogenic progenitors while the emergence of primitive blood cells is not affected

Zahir Shah, Elena S. Filonenko, Vasily Ramensky, Chenyu Fan, Cuihua Wang, Hanif Ullah, Baoyun Zhang, Pavel Volchkov, Igor M. Samokhvalov

https://doi.org/10.3324/haematol.2020.249193

Elastography improves accuracy of early hepato-biliary complications diagnosis after allogeneic stem cell transplantation

Pierre-Edouard Debureaux, Pierre Bourrier, Pierre-Emmanuel Rautou, Anne-Marie Zagdanski, Morgane De Boutiny, Simona Pagliuca, Aurélien Sutra Del Galy, Marie Robin, Régis Peffault de Latour, Aurélie Plessier, Flore Sicre de Fontbrune, Aliénor Xhaard, Pedro Henrique de Lima Prata, Dominique Valla, Gérard Socié, David Michonneau

https://doi.org/10.3324/haematol.2019.245407

Altered T-cell subset repertoire affects treatment outcome of patients with myelofibrosis

Ivo Veletic, Sanja Prijic, Taghi Manshouri, Graciela M. Nogueras-Gonzalez, Srdan Verstovsek, Zeev Estrov

https://doi.org/10.3324/haematol.2020.249441

Hematopoietic recovery and immune reconstitution after axicabtagene ciloleucel in patients with large B-cell lymphoma

Paolo Strati, Ankur Varma, Sherry Adkins, Loretta J. Nastoupil, Jason Westin, Fredrick B. Hagemeister, Nathan H. Fowler, Hun J. Lee, Luis E. Fayad, Felipe Samaniego, Sairah Ahmed, Yiming Chen, Sandra Horowitz, Sara Arafat, Swapna Johncy, Partow Kebriaei, Victor Eduardo Mulanovich, Ella Ariza Heredia, Sattva S. Neelapu

https://doi.org/10.3324/haematol.2020.254045

Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse

Esther Onecha, Inmaculada Rapado, María Luz Morales, Gonzalo Carreño-Tarragona, Pilar Martinez-Sanchez, Xabier Gutierrez, José María Sáchez Pina, María Linares, Miguel Gallardo, Joaquín Martinez-López, Rosa Ayala

https://doi.org/10.3324/haematol.2020.254623

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat

Elisabeth Oppliger Leibundgut, Monika Haubitz, Bart Burington, Oliver G. Ottmann, Gary Spitzer, Olatoyosi Odenike, Michael A. McDevitt, Alexander Röth, David S. Snyder, Gabriela M. Baerlocher

https://doi.org/10.3324/haematol.2020.252817

Case Reports

Acute leucoencephalomyelopathy and quadriparesis after CAR T-cell therapy

Ranjit Nair, Gaëlle Drillet, Faustine Lhomme, Anthony Le Bras, Laure Michel, John Rossi, Marika Sherman, Allen Xue, Anne Kerber, Nutchawan Jittapiromsak, Linda Chi, Sudhakar Tummala, Sattva S. Neelapu, Roch Houot

https://doi.org/10.3324/haematol.2020.259952

Jul 23, 2020

Review Articles

Articles

Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating beta2 integrin clustering

Gabriele Zuchtriegel, Bernd Uhl, Robert Pick, Michaela Ramsauer, Julian Dominik, Laura A. Mittmann, Martin Canis, Sandip Kanse, Markus Sperandio, Fritz Krombach, Christoph A. Reichel

https://doi.org/10.3324/haematol.2019.226241

Cell type specific novel lncRNAs and circRNAs in the BLUEPRINT haematopoietic transcriptomes atlas.

Luigi Grassi, Osagie G. Izuogu, Natasha A.N. Jorge, Denis Seyres, Mariona Bustamante, Frances Burden, Samantha Farrow, Neda Farahi, Fergal J. Martin, Adam Frankish, Jonathan M. Mudge, Myrto Kostadima, Romina Petersen, John J. Lambourne, Sophia Rowlston, Enca Martin-Rendon, Laura Clarke, Kate Downes, Xavier Estivill, Paul Flicek, Joost H.A. Martens, Marie-Laure Yaspo, Hendrik G. Stunnenberg, Willem H. Ouwehand, Fabio Passetti, Ernest Turro, Mattia Frontini

https://doi.org/10.3324/haematol.2019.238147

Letters to the Editor

Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR

Audrey Belot, Ophélie Gourbeyre, Anais Palin, Aude Rubio, Amélie Largounez, Céline Besson-Fournier, Chloé Latour, Megane Lorgouilloux, Inka Gallitz, Alexandra Montagner, Arnaud Polizzi, Marion Régnier, Sarra Smati, An-Sheng Zhang, Manuel D. Diaz-Munoz, Andrea U. Steinbicker, Hervé Guillou, Marie-Paule Roth, Hélène Coppin, Delphine Meynard

https://doi.org/10.3324/haematol.2019.237321

Jul 16, 2020

Articles

Co-occurrence of cohesin complex and Ras signaling mutations during progression from myelodysplastic syndromes to secondary acute myeloid leukemia

Marta Martín-Izquierdo, María Abáigar, Jesús M Hernández-Sánchez, David Tamborero, Félix López-Cadenas, Fernando Ramos, Eva Lumbreras, Andrés Madinaveitia-Ochoa, Marta Megido, Jorge Labrador, Javier Sánchez-Real, Carmen Olivier, Julio Dávila, Carlos Aguilar, Juan N Rodríguez, Guillermo Martín-Nuñez, Sandra Santos-Mínguez, Cristina Miguel-García, Rocío Benito, María Díez-Campelo, Jesús M Hernández-Rivas

https://doi.org/10.3324/haematol.2020.248807

Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B cell–type diffuse large B-cell lymphoma

Lorenz Thurner, Sylvia Hartmann, Moritz Bewarder, Natalie Fadle, Evi Regitz, Claudia Schormann, Natalia Quiroga, Maria Kemele, Wolfram Klapper, Andreas Rosenwald, Lorenz Trümper, Rainer Maria Bohle, Anna Nimmesgern, Christina Körbel, Matthias W. Lascke, Michael D. Menger, Stefan Barth, Boris Kubuschok, Anja Mottok, Dominic Kaddu-Mulindwa, Martin-Leo Hansmann, Viola Pöschel, Gerhard Held, Niels Murawski, Stephan Stilgenbauer, Frank Neumann, Klaus-Dieter Preuss, Michael Pfreundschuh

https://doi.org/10.3324/haematol.2019.241653

Endothelial damage and dysfunction in acute graft-versus-host disease

Steffen Cordes, Zeinab Mokhtari, Maria Bartosova, Sarah Mertlitz, Katarina Riesner, Yu Shi, Jörg Mengwasser, Martina Kalupa, Aleixandria McGeary, Johanna Schleifenbaum, Jens Schrezenmeier, Lars Bullinger, Maribel Diaz-Ricart, Marta Palomo, Enric Carrreras, Gernot Beutel, Claus Peter Schmitt, Andreas Beilhack, Olaf Penack

https://doi.org/10.3324/haematol.2020.253716

BMP signaling is required for postnatal murine hematopoietic stem cell self-renewal

Sarah Warsi, Ulrika Blank, Maria Dahl, Tan Hooi Min Grahn, Ludwig Schmiderer, Silja Andradottir, Stefan Karlsson

https://doi.org/10.3324/haematol.2019.236125

An international, multicenter study of intravenous bevacizumab for bleeding in hereditary hemorrhagic telangiectasia: the InHIBIT-Bleed study

Hanny Al-Samkari, Raj S. Kasthuri, Joseph G. Parambil, Hasan A. Albitar, Yahya A. Almodallal, Carolina Vázquez, Marcelo M. Serra, Sophie Dupuis-Girod, Craig B. Wilsen, Justin P. McWilliams, Evan H. Fountain, James R. Gossage, Clifford R. Weiss, Muhammad A. Latif, Assaf Issachar, Meir Mei-Zahav, Mary E. Meek, Miles Conrad, Josanna Rodriguez-Lopez, David J. Kuter, Vivek N. Iyer

https://doi.org/10.3324/haematol.2020.261859

Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect

Eileen Haring, Franziska M. Uhl, Geoffroy Andrieux, Michele Proietti, Alla Bulashevska, Barbara Sauer, Lukas M. Braun, Enrique de Vega Gomez, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Marie Follo, Annette Schmitt-Graeff, Joerg Buescher, Justus Duyster, Bodo Grimbacher, Melanie Boerries, Erika L. Pearce, Robert Zeiser, Petya Apostolova

https://doi.org/10.3324/haematol.2019.242990

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

Christian W. Thorball, Tiphaine Oudot-Mellakh, Nava Ehsan, Christian Hammer, Federico A. Santoni, Jonathan Niay, Dominique Costagliola, Cécile Goujard, Laurence Meyer, Sophia S. Wang, Shehnaz K. Hussain, Ioannis Theodorou, Matthias Cavassini, Andri Rauch, Manuel Battegay, Matthias Hoffmann, Patrick Schmid, Enos Bernasconi, Huldrych F. Günthard, Pejman Mohammadi, Paul J. McLaren, Charles S. Rabkin, Caroline Besson, Jacques Fellay

https://doi.org/10.3324/haematol.2020.247023

Fenofibrate reduces osteonecrosis without affecting antileukemic efficacy in dexamethasone treated mice

Emily R. Finch, Monique A. Payton, David A. Jenkins, Xiangjun Cai, Lie Li, Seth E. Karol, Mary V. Relling, Laura J. Janke

https://doi.org/10.3324/haematol.2020.252767

Letters to the Editor

Bi 38-3 is a novel CD38/CD3 bispecific T-cell engager with low toxicities for the treatment of multiple myeloma.

Maxime Fayon, Carolina Martinez-Cingolani, Audrey Abecassis, Nathalie Roders, Elisabeth Nelson, Caroline Choisy, Alexis Talbot, Armand Bensussan, Jean-Paul Fermand, Bertrand Arnulf, Jean-Christophe Bories

https://doi.org/10.3324/haematol.2019.242453

Jul 9, 2020

Articles

DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch

Michaela Novakova, Marketa Zaliova, Karel Fiser, Barbora Vakrmanova, Lucie Slamova, Alena Musilova, Monika Brüggemann, Matthias Ritgen, Eva Fronkova, Tomas Kalina, Jan Stary, Lucie Winkowska, Peter Svec, Alexandra Kolenova, Jan Stuchly, Jan Zuna, Jan Trka, Ondrej Hrusak, Ester Mejstrikova

https://doi.org/10.3324/haematol.2020.250423

Survival of patients with newly diagnosed high-grade myeloid neoplasms who do not meet standard trial eligibility

Mary-Elizabeth M. Percival, Megan Othus, Sarah Mirahsani, Kelda M. Gardner, Carole Shaw, Anna B. Halpern, Pamela S. Becker, Paul C. Hendrie, Mohamed L. Sorror, Roland B. Walter, Elihu H. Estey

https://doi.org/10.3324/haematol.2020.254938

Letters to the Editor

Effect of post-consolidation regimen on symptomatic osteonecrosis in three DCOG acute lymphoblastic leukemia protocols

Jenneke E. van Atteveld, Hester A. de Groot-Kruseman, Marta Fiocco, Maarten H. Lequin, Sebastian J.C.M.M. Neggers, Saskia M.F. Pluijm, Inge M. van der Sluis, Rob Pieters, Marry M. van den Heuvel-Eibrink

https://doi.org/10.3324/haematol.2020.257550

Homozygous missense variant in UBE2T is associated with mild Fanconi anemia phenotype

Laura Schultz-Rogers, Francis P. Lach, Kimberly A. Rickman, Alejandro Ferrer, Abhishek A. Mangaonkar, Tanya L. Schwab, Christopher T. Schmitz, Karl J. Clark, Nikita R. Dsouza, Michael T. Zimmermann, Mark Litzow, Nicole Jacobi, Eric W. Klee, Agata Smogorzewska, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2020.259275

Jul 2, 2020

Articles

Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity

Lando Janssen, Nicole M.A. Blijlevens, Meggie M.C.M. Drissen, Esmée A. Bakker, Malou A.H. Nuijten, Jeroen J.W.M. Janssen, Silvie Timmers, Maria T.E. Hopman

https://doi.org/10.3324/haematol.2020.247767

CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity

Julia C. Gutjahr, Elisabeth Bayer, Xiaobing Yu, Julia M. Laufer, Jan P. Höpner, Suzana Tesanovic, Andrea Härzschel, Georg Auer, Tanja Rieß, Astrid Salmhofer, Eva Szenes, Theresa Haslauer, Valerie Durand-Onayli, Andrea Ramspacher, Sandra P. Pennisi, Marc Artinger, Nadja Zaborsky, Alexandre Chigaev, Fritz Aberger, Daniel Neureiter, Lisa Pleyer, Daniel F. Legler, Veronique Orian-Rousseau, Richard Greil, Tanja N. Hartmann

https://doi.org/10.3324/haematol.2019.231944

Jun 25, 2020

Articles

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore, Charity Atkins, Edward R. Long, Monica N. Montoute, Zining Wu, Wendy Halsey, Dean E. McNulty, Daniela Ennulat, Lourdes Rueda, Melissa Pappalardi, Ryan G. Kruger, Michael T. McCabe, Ali Raoof, Roger Butlin, Alexandra Stowell, Mark Cockerill, Ian Waddell, Donald Ogilvie, Juan Luengo, Allan Jordan, Andrew B. Benowitz

https://doi.org/10.3324/haematol.2020.248658

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis

Ana B. Arroyo, María P. Fernández-Pérez, Alberto del Monte, Sonia Águila, Raúl Méndez, Rebecca Hernández-Antolín, Nuria García-Barber, Ascensión M de los Reyes-García, Paula González-Jiménez, María I. Arcas, Vicente Vicente, Rosario Menéndez, Vicente Andrés, Rocío González-Conejero, Constantino Martínez

https://doi.org/10.3324/haematol.2019.240226

Letters to the Editor

Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis

Fredrik H. Schjesvold, Paul G. Richardson, Thierry Facon, Adrián Alegre, Andrew Spencer, Artur Jurczyszyn, Kazutaka Sunami, Laurent Frenzel, Chang-Ki Min, Sophie Guillonneau, Peggy L. Lin, Solenn Le-Guennec, Frank Campana, Helgi van de Velde, Samira Bensfia, Sara Bringhen

https://doi.org/10.3324/haematol.2020.253450

Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma.

Keiichiro Watanabe, Ariunzaya Bat-Erdene, Hirofumi Tenshin, Qu Cui, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Takeshi Harada, Hirokazu Miki, Kimiko Sogabe, Masahiro Oura, Ryohei Sumitani, Yukari Mitsui, Itsuro Endo, Eiji Tanaka, Makoto Kawatani, Hiroyuki Osada, Toshio Matsumoto, Masahiro Abe

https://doi.org/10.3324/haematol.2019.244418

Infrequent "chronic lymphocytic leukemia-specific" immunoglobulin stereotypes in aged individuals with or without low count monoclonal B cell lymphocytosis

Andreas Agathangelidis, Chrysi Galigalidou, Lydia Scarfò, Theodoros Moysiadis, Alessandra Rovida, Maria Gounari, Fotis Psomopoulos, Pamela Ranghetti, Alex Galanis, Frederic Davi, Kostas Stamatopoulos, Anastasia Chatzidimitriou, Paolo Ghia

https://doi.org/10.3324/haematol.2020.247908

Jun 18, 2020

Articles

Impact on survival through consolidation radiotherapy for diffuse large B-cell lymphoma: a comprehensive meta-analysis

Martin D. Berger, Sven Trelle, Annina E. Büchi, Sabrina Jegerlehner, Codruta Ionescu, Thierry Lamy de la Chapelle, Urban Novak

https://doi.org/10.3324/haematol.2020.249680

Comparison of total body irradiation versus non- total body irradiation containing regimens for de novo acute myeloid leukemia in children

Christopher E. Dandoy, Stella M. Davies, Kwang Woo Ahn, Yizeng He, Anders E. Kolb, John Levine, Stephanie Bo-Subait, Hisham Abdel-Azim, Neel Bhatt, Joseph Chewing, Shahinaz Gadalla, Nicholas Gloude, Robert Hayashi, Nahal R. Lalefar, Jason Law, Margaret MacMillan, Tracy O'Brien, Timothy Prestidge, Akshay Sharma, Peter Shaw, Lena Winestone, Mary Eapen

https://doi.org/10.3324/haematol.2020.249458

Letters to the Editor

Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance.

Hannah Åbacka, Jesper S. Hansen, Peng Huang, Raminta Venskutonytė, Axel Hyrenius-Wittsten, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Filippo Minutolo, Anna K. Hagström-Andersson, Karin Lindkvist-Petersson

https://doi.org/10.3324/haematol.2020.246843

Human platelets are a source of collagen I

Anastasia Kyselova, Sven Zukunft, Deborah Puppe, Ilka Wittig, W. Alexander Mann, Imke Dornauf, Ingrid Fleming, Voahanginirina Randriamboavonjy

https://doi.org/10.3324/haematol.2020.255612

Germline pathogenic variants in transcription factors predisposing to pediatric acute myeloid leukemia: results from the French ELAM02 trial

Laurène Fenwarth, Nicolas Duployez, Alice Marceau-Renaut, Wadih Abou Chahla, Stéphane Ducassou, Virginie Gandemer, Marlène Pasquet, Thierry Leblanc, Pascale Schneider, Carine Domenech, Paul Saultier, Guy Leverger, Hélène Lapillonne, Claude Preudhomme, Arnaud Petit

https://doi.org/10.3324/haematol.2020.248872

Concomitant constitutive LNK and NFE2 mutation with loss of sumoylation in a case of hereditary thrombocythemia

Lukas Clemens Böckelmann, Titiksha Basu, Albert Gründer, Wei Wang, Jan Breucker, Sandra Kaiser, Andrea Pichler, Heike Luise Pahl

https://doi.org/10.3324/haematol.2020.246587

Jun 11, 2020

Articles

Efficacy of minimal residual disease driven immune-intervention after allogeneic hematopoietic stem cell transplantation for high-risk chronic lymphocytic leukemia: results of a prospective multicentric trial

Olivier Tournilhac, Magali Le Garff-Tavernier, Stéphanie Nguyen Quoc, Edouard Forcade, Patrice Chevallier, Faezeh Legrand-Izadifar, Gandhi Laurent Damaj, David Michonneau, Cécile Tomowiak, Cécile Borel, Corentin Orvain, Pascal Turlure, Rabah Redjou, Gaëlle Guillerm, Laure Vincent, Celestine Simand, Richard Lemal, Claire Quiney, Patricia Combes, Bruno Pereira, Laure Calvet, Aurélie Cabrespine, Jacques-Olivier Bay, Véronique Leblond, Nathalie Dhédin, French Innovative Leukemia Organization (FILO), Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

https://doi.org/10.3324/haematol.2019.239566

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

Gaëtan Juban, Nathalie Sakakini, Hedia Chagraoui, David Cruz Hernandez, Qian Cheng, Kelly Soady, Bilyana Stoilova, Catherine Garnett, Dominic Waithe, Georg Otto, Jessica Doondeea, Batchimeg Usukhbayar, Elena Karkoulia, Maria Alexiou, John Strouboulis, Edward Morrissey, Irene Roberts, Catherine Porcher, Paresh Vyas

https://doi.org/10.3324/haematol.2019.244541

Jun 4, 2020

Articles

Allogeneic hematopoietic cell transplantation with non-myeloablative conditioning for patients with hematologic malignancies: Improved outcomes over two decades

Jason P. Cooper, Barry E. Storer, Noa Granot, Boglark Gyurkocza, Mohamed L. Sorror, Thomas R. Chauncey, Judith Shizuru, Georg-Nikolaus Franke, Michael B. Maris, Michael Boyer, Benedetto Bruno, Firoozeh Sahebi, Amelia A. Langston, Parameswaran Hari, Edward D. Agura, Søren Lykke Petersen, Richard T. Maziarz, Wolfgang Bethge, Julie Asch, Jonathan A. Gutman, Gitte Olesen, Andrew M. Yeager, Kai Hübel, William J. Hogan, David G. Maloney, Marco Mielcarek, Paul J. Martin, Mary E.D. Flowers, George E. Georges, Ann E. Woolfrey, H. Joachim Deeg, Bart L. Scott, George B. McDonald, Rainer Storb, Brenda M. Sandmaier

https://doi.org/10.3324/haematol.2020.248187

Fc-engineering significantly improves the recruitment of immune effector cells by anti-ICAM-1 antibody MSH-TP15 for myeloma therapy

Katja Klausz, Michael Cieker, Christian Kellner, Thies Rösner, Anna Otte, Steffen Krohn, Anja Lux, Falk Nimmerjahn, Thomas Valerius, Martin Gramatzki, Matthias Peipp

https://doi.org/10.3324/haematol.2020.251371

Lenalidomide before and after ASCT for transplant-eligible patients of all ages in the randomized, phase III, Myeloma XI trial

Graham H. Jackson, Faith E. Davies, Charlotte Pawlyn, David A. Cairns, Alina Striha, Corinne Collett, Anna Waterhouse, John R. Jones, Bhuvan Kishore, Mamta Garg, Cathy D. Williams, Kamaraj Karunanithi, Jindriska Lindsay, David Allotey, Salim Shafeek, Matthew W. Jenner, Gordon Cook, Nigel H. Russell, Martin F. Kaiser, Mark T. Drayson, Roger G. Owen, Walter M. Gregory, Gareth J. Morgan, UK NCRI Haematological Oncology Clinical Studies Group

https://doi.org/10.3324/haematol.2020.247130

Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores the angiogenic homeostasis and suppresses tumor progression.

Antonio G. Solimando, Matteo C. Da Vià, Patrizia Leone, Paola Borrelli, Giorgio A. Croci, Paula Tabares, Andreas Brandl, Giuseppe Di Lernia, Francesco P. Bianchi, Silvio Tafuri, Torsten Steinbrunn, Alessandra Balduini, Assunta Melaccio, Simona De Summa, Antonella Argentiero, Hilka Rauert-Wunderlich, Maria A. Frassanito, Paolo Ditonno, Erik Henke, Wolfram Klapper, Roberto Ria, Carolina Terragna, Leo Rasche, Andreas Rosenwald, K. Martin Kortüm, Michele Cavo, Domenico Ribatti, Vito Racanelli, Hermann Einsele, Angelo Vacca, Andreas Beilhack

https://doi.org/10.3324/haematol.2019.239913

Letters to the Editor

Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression

Ivan Sloma, Philip Beer, Christophe Desterke, Elizabeth Bulaeva, Misha Bilenky, Annaïck Carles, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G. Turhan, Orianne Wagner-Ballon, Philippe Gaulard, Keith Humphries, Martin Hirst, Connie J. Eaves

https://doi.org/10.3324/haematol.2020.249243

Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia

Marketa Zaliova, Eliska Potuckova, Julius Lukes, Lucie Winkowska, Julia Starkova, Iveta Janotova, Lucie Sramkova, Jan Stary, Jan Zuna, Martin Stanulla, Martin Zimmermann, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert, Gunnar Cario, Jan Trka

https://doi.org/10.3324/haematol.2020.249094

Outcomes of relapsed or refractory acute myeloid leukemia after frontline hypomethylating agent and venetoclax regimens

Abhishek Maiti, Caitlin R. Rausch, Jorge E. Cortes, Naveen Pemmaraju, Naval G. Daver, Farhad Ravandi, Guillermo Garcia-Manero, Gautam Borthakur, Kiran Naqvi, Maro Ohanian, Nicholas J. Short, Yesid Alvarado, Tapan M. Kadia, Koichi Takahashi, Musa Yilmaz, Nitin Jain, Steven Kornblau, Guillermo Montalban Bravo, Koji Sasaki, Michael Andreeff, Prithiviraj Bose, Alessandra Ferrajoli, Ghayas C. Issa, Elias J. Jabbour, Lucia Masarova, Philip A. Thompson, Sa Wang, Sergej Konoplev, Sherry A. Pierce, Jing Ning, Wei Qiao, John S. Welch, Hagop M. Kantarjian, Courtney D. DiNardo, Marina Y. Konopleva

https://doi.org/10.3324/haematol.2020.252569

May 28, 2020

Articles

Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913

Sabina Chiaretti, Monica Messina, Irene Della Starza, Alfonso Piciocchi, Luciana Cafforio, Marzia Cavalli, Akram Taherinasab, Michela Ansuinelli, Loredana Elia, Guglielmo Albertini Petroni, Roberta La Starza, Martina Canichella, Alessia Lauretti, Maria Ctristina Puzzolo, Valentina Pierini, Alessandra Santoro, Orietta Spinelli, Valerio Apicella, Saveria Capria, Francesco Di Raimondo, Paolo De Fabritiis, Cristina Papayannidis, Anna Candoni, Roberto Cairoli, Marco Cerrano, Nicola Fracchiolla, Daniele Mattei, Chiara Cattaneo, Antonella Vitale, Enrico Crea, Paola Fazi, Cristina Mecucci, Alessandro Rambaldi, Anna Guarini, Renato Bassan, Robin Foà

https://doi.org/10.3324/haematol.2020.247973

Deciphering the Ets-1/2-mediated transcriptional regulation of F8 gene identifies a minimal F8 promoter for hemophilia A gene therapy

Rosella Famà, Ester Borroni, Simone Merlin, Chiara Airoldi, Silvia Pignani, Alessia Cucci, Davide Corà, Valentina Bruscaggin, Sharon Scardellato, Stefania Faletti, Giuliana Pelicci, Mirko Pinotti, Gillian E. Walker, Antonia Follenzi

https://doi.org/10.3324/haematol.2019.239202

Anti-RhD antibody therapy modulates human natural killer cell function

Shlomo Elias, Inbal Kol, Shira Kahlon, Rajaa Amore, Mariam Zeibak, Dror Mevorach, Uriel Elchalal, Orly Zelig, Ofer Mandelboim

https://doi.org/10.3324/haematol.2019.238097

Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling

Amanda J. Unsworth, Alexander P. Bye, Tanya Sage, Renato S. Gaspar, Nathan Eaton, Caleb Drew, Alexander Stainer, Neline Kriek, Peter J. Volberding, James L. Hutchinson, Ryan Riley, Sarah Jones, Stuart J. Mundell, Weiguo Cui, Hervé Falet, Jonathan M. Gibbins

https://doi.org/10.3324/haematol.2019.223529

Letters to the Editor

Clinical spectrum and therapeutic management of auto-immune myelofibrosis: a nation-wide study of 30 cases

Philippe Mertz, Emilie Chalayer, Zahir Amoura, Pascal Cathebras, Laurent Chiche, Nathalie Coestedoat, Alban Deroux, Elisabeth Diot, Stéphane Durupt, Emmanuel Forestier, Audrey Gorse, Laurent Hudier, Martin Killian, Olivier Lambotte, Claire Lecomte, Emmanuel Ledoult, Camille Martinez, Alexis Mathian, Anne Sophie Morin, Nicolas Noel, Marc Pineton De Chambrun, Louis Terriou, Jean Sibilia, Jacques-Eric Gottenberg, Anne-Sophie Korganow, Laurent Arnaud, Thierry Martin

https://doi.org/10.3324/haematol.2020.249896

May 21, 2020

Articles

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance

Alisa Dong, Valentina Ghiaccio, Irene Motta, Shuling Guo, Raechel Peralta, Susan M. Freier, Andy Watt, Sagar Damle, Yasuhiro Ikawa, Danuta Jarocha, Maxwell Chappell, Coralea Stephanou, Paola Delbini, Connie Chen, Soteroula Christou, Marina Kleanthous, Kim Smith-Whitley, Deepa Manwani, Carla Casu, Osheiza Abdulmalik, Maria Domenica Cappellini, Stefano Rivella, Laura Breda

https://doi.org/10.3324/haematol.2019.226852

A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia

Hiroki Mizumaki, Kazuyoshi Hosomichi, Kohei Hosokawa, Takeshi Yoroidaka, Tatsuya Imi, Yoshitaka Zaimoku, Takamasa Katagiri, Mai Anh Thi Nguyen, Dung Cao Tran, Mahmoud Ibrahim Yousef Elbadry, Kazuhisa Chonabayashi, Yoshinori Yoshida, Hiroyuki Takamatsu, Tatsuhiko Ozawa, Fumihiro Azuma, Hiroyuki Kishi, Yoichi Fujii, Seishi Ogawa, Atsushi Tajima, Shinji Nakao

https://doi.org/10.3324/haematol.2020.247809

May 15, 2020

Articles

Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia

Chujing Zhang, Stella Amanda, Cheng Wang, Tze King Tan, Muhammad Zulfaqar Ali, Wei Zhong Leong, Ley Moy Ng, Shojiro Kitajima, Zhenhua Li, Allen Eng Juh Yeoh, Shi Hao Tan, Takaomi Sanda

https://doi.org/10.3324/haematol.2019.245639

Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma

Naoki Oishi, Tanya Hundal, Jessica L. Phillips, Surendra Dasari, Guangzhen Hu, David S. Viswanatha, Rong He, Ming Mai, Hailey K. Jacobs, Nada H. Ahmed, Sergei I. Syrbu, Youssef Salama, Jennifer R. Chapman, Francisco Vega, Jagmohan Sidhu, N. Nora Bennani, Alan L. Epstein, L. Jeffrey Medeiros, Mark W. Clemens, Roberto N. Miranda, Andrew L. Feldman

https://doi.org/10.3324/haematol.2019.245860

Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models

Raghuveer Singh Mali, Qi Zhang, RosaAnna DeFilippis, Antonio Cavazos, Vinitha Mary Kuruvilla, Jayant Raman, Vidhi Mody, Edna F. Choo, Monique Dail, Neil P. Shah, Marina Konopleva, Deepak Sampath, Elisabeth A. Lasater

https://doi.org/10.3324/haematol.2019.244020

Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia

Nyla A. Heerema, Natarajan Muthusamy, Qiuhong Zhao, Amy S. Ruppert, Heather Breidenbach, Leslie A. Andritsos, Michael R. Grever, Kami J. Maddocks, Jennifer Woyach, Farrukh Awan, Meixiao Long, Amber Gordon, Caitlin Coombes, John C. Byrd

https://doi.org/10.3324/haematol.2018.212571

Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia

Joseph P. Loftus, Anella Yahiaoui, Patrick A. Brown, Lisa M. Niswander, Asen Bagashev, Min Wang, Allyson Schauf, Stacey Tannheimer, Sarah K. Tasian

https://doi.org/10.3324/haematol.2019.241729

Brentuximab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone as frontline treatment for patients with CD30-positive B-cell lymphomas

Jakub Svoboda, Steven M. Bair, Daniel J. Landsburg, Sunita Dwivedy Nasta, Sarah J. Nagle, Stefan K. Barta, Nadia Khan, Joanne Filicko-O'Hara, Sameh Gaballa, Lauren Strelec, Elise Chong, Sheryl Mitnick, Terease S. Waite, Cara King, Hatcher Ballard, Matthew Youngman, James Gerson, John P. Plastaras, Amit Maity, Agata M. Bogusz, Stacy S. Hung, Hisae Nakamura, Reza Nejati, Christian Steidl, Megan Lim, Marco Ruella, Stephen J. Schuster

https://doi.org/10.3324/haematol.2019.238675

Letters to the Editor

Validation of the revised myeloma comorbidity index and other comorbidity scores in a multicenter German study group multiple myeloma trial

Sandra Maria Dold, Mandy-Deborah Möller, Gabriele Ihorst, Christian Langer, Wolfram Pönisch, Lars-Olof Mügge, Stefan Knop, Johannes Jung, Christine Greil, Ralph Wäsch, Monika Engelhardt

https://doi.org/10.3324/haematol.2020.254235

CCND2 mutations are infrequent events in BCR-ABL1 negative myeloproliferative neoplasm patients

Bruno Cassinat, Emmanuelle Verger, Nabih Maslah, Nicolas Gauthier, William Vainchenker, Stéphane Giraudier, Jean-Jacques Kiladjian

https://doi.org/10.3324/haematol.2020.252643

May 7, 2020

Articles

The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia

Teresa D'Altri, Anna S. Wilhelmson, Mikkel B. Schuster, Anne Wenzel, Adrija Kalvisa, Sachin Pundhir, Anne Meldgaard Hansen, Bo T. Porse

https://doi.org/10.3324/haematol.2019.235150

Analysis of the tumor microenvironment by whole-slide image analysis identifies low B cell content as a predictor of adverse outcome in advanced-stage classical Hodgkin lymphoma treated with BEACOPP

Ron Daniel Jachimowicz, Luise Pieper, Sarah Reinke, Artur Gontarewicz, Annette Plütschow, Heinz Haverkamp, Leonie Frauenfeld, Falko Fend, Mathis Overkamp, Franziska Jochims, Christoph Thorns, Martin Leo Hansmann, Peter Möller, Andreas Rosenwald, Harald Stein, Hans Christian Reinhardt, Peter Borchmann, Bastian von Tresckow, Andreas Engert, Wolfram Klapper

https://doi.org/10.3324/haematol.2019.243287

CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T-cells

Marika Guercio, Domenico Orlando, Stefano Di Cecca, Matilde Sinibaldi, Iolanda Boffa, Simona Caruso, Zeinab Abbaszadeh, Antonio Camera, Biancamaria Cembrola, Katia Bovetti, Simona Manni, Ignazio Caruana, Roselia Ciccone, Francesca Del Bufalo, Pietro Merli, Luciana Vinti, Katia Girardi, Annalisa Ruggeri, Cristiano De Stefanis, Marco Pezzullo, Ezio Giorda, Marco Scarsella, Rita De Vito, Sabina Barresi, Andrea Ciolfi, Marco Tartaglia, Lorenzo Moretta, Franco Locatelli, Concetta Quintarelli, Biagio De Angelis

https://doi.org/10.3324/haematol.2019.231183

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers

Thomas Lewis, David B. Corcoran, David E. Thurston, Peter J. Giles, Kevin Ashelford, Elisabeth J. Walsby, Christopher D. Fegan, Andrea G.S. Pepper, Khondaker Miraz Rahman, Chris Pepper

https://doi.org/10.3324/haematol.2019.238584

Letters to the Editor

Clinical activity of abemaciclib in patients with relapsed or refractory mantle cell lymphoma - a phase II study

Franck Morschhauser, Kamal Bouabdallah, Stephan Stilgenbauer, Catherine Thieblemont, Sophie de Guibert, Florian Zettl, Lawrence M. Gelbert, P. Kellie Turner, Siva Rama Prasad Kambhampati, Li Li, Lily Q. Li, Sean Buchanan, Susana Barriga, Melissa M. Bear, Martin Wilhelm, Georg Hess

https://doi.org/10.3324/haematol.2019.224535

Acute myeloid leukemia shapes the bone marrow stromal niche in vivo

Alice Pievani, Samantha Donsante, Chiara Tomasoni, Alessandro Corsi, Francesco Dazzi, Andrea Biondi, Mara Riminucci, Marta Serafini

https://doi.org/10.3324/haematol.2020.247205

Apr 30, 2020

Articles

Subcutaneous daratumumab in patients with relapsed or refractory multiple myeloma: Part 2 of the open-label, multicenter, dose-escalation phase 1b study (PAVO)

Jesus San-Miguel, Saad Z. Usmani, Maria-Victoria Mateos, Niels W.C.J. van de Donk, Jonathan L. Kaufman, Philippe Moreau, Albert Oriol, Torben Plesner, Lotfi Benboubker, Kevin Liu, Peter Hellemans, Tara Masterson, Pamela L. Clemens, Man Luo, Andrew Farnsworth, Hareth Nahi, Ajai Chari

https://doi.org/10.3324/haematol.2019.243790

Post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prevention in haploidentical transplantation for adult acute lymphoblastic leukemia

Arnon Nagler, Abraham S. Kanate, Myriam Labopin, Fabio Ciceri, Emanuele Angelucci, Yener Koc, Zafer Gülbas, William Arcese, Johanna Tischer, Pietro Pioltelli, Hakan Ozdogu, Boris Afanasyev, Depei Wu, Mutlu Arat, Zinaida Peric, Sebastian Giebel, Bipin Savani, Mohamad Mohty

https://doi.org/10.3324/haematol.2020.247296

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice

Sara Fañanas-Baquero, Israel Orman, Federico Becerra Aparicio, Silvia Bermudez de Miguel, Jordi Garcia Merino, Rosa Yañez, Yolanda Fernandez Sainz, Rebeca Sánchez, Mercedes Dessy-Rodríguez, Omaira Alberquilla, David Alfaro, Agustin Zapata, Juan A. Bueren, Jose Carlos Segovia, Oscar Quintana-Bustamante

https://doi.org/10.3324/haematol.2019.233924

Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk

Rhodri J. King, Katharina Schuett, Christian Tiede, Vera Jankowski, Vicky John, Abhi Trehan, Katie Simmons, Sreenivasan Ponnambalam, Robert F. Storey, Colin W.G. Fishwick, Michael J. McPherson, Darren C. Tomlinson, Ramzi A. Ajjan

https://doi.org/10.3324/haematol.2019.239558

Letters to the Editor

Apr 23, 2020

Articles

Immune reconstitution and associated infections following axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma

Jennifer M. Logue, Elisa Zucchetti, Christina A. Bachmeier, Gabriel S. Krivenko, Victoria Larson, Daniel Ninh, Giovanni Grillo, Biwei Cao, Jongphil Kim, Julio C. Chavez, Aliyah Baluch, Farhad Khimani, Aleksandr Lazaryan, Taiga Nishihori, Hien D. Liu, Javier Pinilla-Ibarz, Bijal D. Shah, Rawan Faramand, Anna E. Coghill, Marco L. Davila, Bhagirathbhai R. Dholaria, Michael D. Jain, Frederick L. Locke

https://doi.org/10.3324/haematol.2019.238634

Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target

Hugo Larose, Nina Prokoph, Jamie D. Matthews, Michaela Schlederer, Sandra Högler, Ali F. Alsulami, Stephen P. Ducray, Edem Nuglozeh, Feroze M.S. Fazaludeen, Ahmed Elmouna, Monica Ceccon, Luca Mologni, Carlo Gambacorti-Passerini, Gerald Hoefler, Cosimo Lobello, Sarka Pospisilova, Andrea Janikova, Wilhelm Woessmann, Christine Damm-Welk, Martin Zimmermann, Alina Federova, Andrea Malone, Owen Smith, Mariusz Wasik, Giorgio Inghirami, Laurence Lamant, Tom L. Blundell, Wolfram Klapper, Olaf Merkel, G.A. Amos Burke, Shahid Mian, Ibraheem Ashankyty, Lukas Kenner, Suzanne D. Turner

https://doi.org/10.3324/haematol.2019.238766

A zebrafish model for HAX1-associated congenital neutropenia

Larissa Doll, Narges Aghaallaei, Advaita M. Dick, Karl Welte, Julia Skokowa, Baubak Bajoghli

https://doi.org/10.3324/haematol.2019.240200

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann

https://doi.org/10.3324/haematol.2019.228064

Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells

Ismael Boussaid, Salomé Le Goff, Célia Floquet, Emilie-Fleur Gautier, Anna Raimbault, Pierre-Julien Viailly, Dina Al Dulaimi, Barbara Burroni, Isabelle Dusanter-Fourt, Isabelle Hatin, Patrick Mayeux, Bertrand Cosson, Michaela Fontenay

https://doi.org/10.3324/haematol.2019.239970

Factor VIII activity and bleeding risk during prophylaxis for severe hemophilia A: a population pharmacokinetic model

Andreas Tiede, Faraizah Abdul Karim, Victor Jiménez-Yuste, Robert Klamroth, Sandra Lejniece, Takashi Suzuki, Andreas Groth, Elena Santagostino

https://doi.org/10.3324/haematol.2019.241554

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation

Alicia Bornert, Julie Boscher, Fabien Pertuy, Anita Eckly, David Stegner, Catherine Strassel, Christian Gachet, François Lanza, Catherine Léon

https://doi.org/10.3324/haematol.2019.239111

Apr 17, 2020

Articles

Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver

Xiaolin Ma, Yun Li, Yuji Kondo, Huiping Shi, Jingjing Han, Yizhi Jiang, Xia Bai, Stephanie A. Archer-Hartmann, Parastoo Azadi, Changgeng Ruan, Jianxin Fu, Lijun Xia, Jiangsu Institute of Hematology, Soochow University, China

https://doi.org/10.3324/haematol.2019.225987

Apr 16, 2020

Articles

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

Melissa V Chan, Melissa A Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E Allan, Matthew L Edin, Darryl C Zeldin, Ginger L Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B O'Donnell, Liang Dong, Michael G Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H Ouwehand, Ernest Turro, NIHR BioResource, Daniel P Hart, Kathleen Freson, Michael A Laffan, Timothy D Warner

https://doi.org/10.3324/haematol.2019.235895

Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia

Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio

https://doi.org/10.3324/haematol.2019.242016

Second malignancies after treatment of childhood non-Hodgkin lymphoma: a report of the Berlin-Frankfurt-Muenster study group

Olga Moser, Martin Zimmermann, Ulrike Meyer, Wolfram Klapper, Ilske Oschlies, Martin Schrappe, Andishe Attarbaschi, Georg Mann, Felix Niggli, Claudia Spix, Udo Kontny, Thomas Klingebiel, Alfred Reiter, Birgit Burkhardt, Wilhelm Woessmann

https://doi.org/10.3324/haematol.2019.244780

Apr 9, 2020

Articles

MYC rearrangement but not extra MYC copies is an independent prognostic factor in patients with mantle cell lymphoma

Lifu Wang, Guilin Tang, L. Jeffrey Medeiros, Jie Xu, Wenting Huang, C. Cameron Yin, Michael Wang, Preetesh Jain, Pei Lin, Shaoying Li

https://doi.org/10.3324/haematol.2019.243071

Genetic lesions in MYC and STAT3 drive oncogenic transcription factor overexpression in plasmablastic lymphoma.

Julia Garcia-Reyero, Nerea Martinez Magunacelaya, Sonia Gonzalez de Villambrosia, Sanam Loghavi, Angela Gomez Mediavilla, Raul Tonda, Sergi Beltran, Marta Gut, Ainara Pereña Gonzalez, Emanuele d' Ámore, Carlo Visco, Joseph D. Khoury, Santiago Montes-Moreno

https://doi.org/10.3324/haematol.2020.251579

Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study

Marie José Kersten, Julia Driessen, Josée M. Zijlstra, Wouter J. Plattel, Franck Morschhauser, Pieternella J. Lugtenburg, Pauline Brice, Martin Hutchings, Thomas Gastinne, Roberto Liu, Coreline N. Burggraaff, Marcel Nijland, Sanne H. Tonino, Anne I. J. Arens, Roelf Valkema, Harm van Tinteren, Marta Lopez-Yurda, Arjan Diepstra, Daphne De Jong, Anton Hagenbeek

https://doi.org/10.3324/haematol.2019.243238

TAK1 is a pivotal therapeutic target for tumor progression and bone destruction in myeloma

Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Asuka Oda, Ariunzaya Bat-Erdene, Takeshi Harada, Shingen Nakamura, Mohannad Ashtar, So Shimizu, Masami Iwasa, Kimiko Sogabe, Masahiro Oura, Shiro Fujii, Kumiko Kagawa, Hirokazu Miki, Itsuro Endo, Tatsuji Haneji, Toshio Matsumoto, Masahiro Abe

https://doi.org/10.3324/haematol.2019.234476

Case Reports

Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia

Barbara Schmaltz-Panneau, Anne Pagnier, Séverine Clauin, Julien Buratti, Caroline Marty, Odile Fenneteau, Klaus Dieterich, Blandine Beaupain, Jean Donadieu, Isabelle Plo, Christine Bellanné-Chantelot

https://doi.org/10.3324/haematol.2020.247825

Apr 2, 2020

Articles

Endothelial injury, F-actin and vitamin-D binding protein after hematopoietic stem cell transplant and association with clinical outcomes

Nathan Luebbering, Sheyar Abdullah, Dana Lounder, Adam Lane, Nikhil Dole, Jeremy Rubinstein, Martin Hewison, Nicholas Gloude, Sonata Jodele, Kitty M.R. Perentesis, Kelly Lake, Bridget Litts, Alexandra Duell, Christopher E. Dandoy, Stella M. Davies

https://doi.org/10.3324/haematol.2019.233478

Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity

Angelo D'Alessandro, Xiaoyun Fu, Tamir Kanias, Julie A. Reisz, Rachel Culp-Hill, Yuelong Guo, Mark T. Gladwin, Grier Page, Steven Kleinman, Marion Lanteri, Mars Stone, Michael P. Busch, James C. Zimring, Recipient Epidemiology and Donor Evaluation Study-III (REDS III)

https://doi.org/10.3324/haematol.2020.246603

Genotype-phenotype association and variant characterization in Diamond-Blackfan anemia caused by pathogenic variants in RPL35A

D. Matthew Gianferante, Marcin W. Wlodarski, Evangelia Atsidaftos, Lydie Da Costa, Polyxeni Delaporta, Jason E. Farrar, Frederick D. Goldman, Maryam Hussain, Antonis Kattamis, Thierry Leblanc, Jeffrey M. Lipton, Charlotte M. Niemeyer, Dagmar Pospisilova, Paola Quarello, Ugo Ramenghi, Vijay G. Sankaran, Adrianna Vlachos, Jana Volejnikova, Blanche P. Alter, Sharon A. Savage, Neelam Giri

https://doi.org/10.3324/haematol.2020.246629

Mar 26, 2020

Articles

Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport

Ellie Karampini, Petra E. Bürgisser, Jenny Olins, Aat A. Mulder, Carolina R. Jost, Dirk Geerts, Jan Voorberg, Ruben Bierings

https://doi.org/10.3324/haematol.2019.242727

Stem cell factor is implicated in microenvironmental interactions and cellular dynamics of chronic lymphocytic leukemia

George I. Gavriilidis, Stavroula Ntoufa, Nikos Papakonstantinou, Konstantia Kotta, Triantafyllia Koletsa, Elisavet Chartomatsidou, Theodoros Moysiadis, Niki Stavroyianni, Achilles Anagnostopoulos, Eleni Papadaki, Asterios S. Tsiftsoglou, Kostas Stamatopoulos

https://doi.org/10.3324/haematol.2019.236513

Mar 19, 2020

Articles

The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma

Manuel Montesinos-Rongen, Monica Terrao, Caroline May, Katrin Marcus, Ingmar Blümcke, Martin Hellmich, Ralf Küppers, Anna Brunn, Martina Deckert

https://doi.org/10.3324/haematol.2019.242701

Mar 12, 2020

Articles

The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia

Xinyu Li, Yongwei Su, Katie Hege, Gerard Madlambayan, Holly Edwards, Tristan Knight, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jay Yang, Regan Miller, Guan Wang, Lijing Zhao, Yue Wang, Hai Lin, Jeffrey W. Taub, Yubin Ge

https://doi.org/10.3324/haematol.2019.233445

P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3

Wenli Feng, Xiao Yang, Lina Wang, Rong Wang, Feifei Yang, Hao Wang, Xiaoli Liu, Qian Ren, Yingchi Zhang, Xiaofan Zhu, Guoguang Zheng

https://doi.org/10.3324/haematol.2019.243360

Mar 5, 2020

Articles

Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia

Yuzhe Shi, Melanie C. Beckett, Helen J. Blair, Ricky Tirtakusuma, Sirintra Nakjang, Amir Enshaei, Christina Halsey, Josef Vormoor, Olaf Heidenreich, Anja Krippner-Heidenreich, Frederik W. van Delft

https://doi.org/10.3324/haematol.2019.241026

Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice

Bola S. Hanna, Haniyeh Yazdanparast, Yasmin Demerdash, Philipp M. Roessner, Ralph Schulz, Peter Lichter, Stephan Stilgenbauer, Martina Seiffert

https://doi.org/10.3324/haematol.2019.238154

Feb 27, 2020

Articles

Response-adapted therapy with infusional EPOCH chemotherapy plus rituximab in HIV- associated, B-cell non-Hodgkin's lymphoma

Joseph A. Sparano, Jeannette Y. Lee, Lawrence D. Kaplan, Juan Carlos Ramos, Richard F. Ambinder, William Wachsman, David Aboulafia, Ariela Noy, David H. Henry, Lee Ratner, Ethel Cesarman, Amy Chadburn, Ronald Mitsuyasu

https://doi.org/10.3324/haematol.2019.243386

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice

Antonella Nai, Maria Rosa Lidonnici, Giorgia Federico, Mariateresa Pettinato, Violante Olivari, Federica Carrillo, Simonetta Geninatti Crich, Giuliana Ferrari, Clara Camaschella, Laura Silvestri, Francesca Carlomagno

https://doi.org/10.3324/haematol.2019.241232

The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice

Frederik Denorme, Kimberly Martinod, Aline Vandenbulcke, Cécile V. Denis, Peter J. Lenting, Hans Deckmyn, Karen Vanhoorelbeke, Simon F. De Meyer

https://doi.org/10.3324/haematol.2019.241042

Carfilzomib, cyclophosphamide and dexamethasone for newly diagnosed, high-risk myeloma patients not eligible for transplant: a pooled analysis of two studies

Roberto Mina, Francesca Bonello, Maria Teresa Petrucci, Anna Marina Liberati, Concetta Conticello, Stelvio Ballanti, Pellegrino Musto, Attilio Olivieri, Giulia Benevolo, Andrea Capra, Milena Gilestro, Piero Galieni, Michele Cavo, Agostina Siniscalchi, Antonio Palumbo, Vittorio Montefusco, Gianluca Gaidano, Paola Omedé, Mario Boccadoro, Sara Bringhen

https://doi.org/10.3324/haematol.2019.243428

Feb 20, 2020

Articles

G-CSF directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells

Miner Xie, Shanshan Zhang, Fang Dong, Qingyun Zhang, Jinhong Wang, Chenchen Wang, Caiying Zhu, Sen Zhang, Bingqing Luo, Peng Wu, Hideo Ema

https://doi.org/10.3324/haematol.2019.239251

Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia

Xin Li, Zi Sheng, Yuanxin Sun, Yuanjian Wang, Miao Xu, Zhiyue Zhang, Hui Li, Linlin Shao, Yanqi Zhang, Jinming Yu, Chunhong Ma, Chengjiang Gao, Ming Hou, Heyu Ni, Jun Peng, Ji Ma, Qi Feng

https://doi.org/10.3324/haematol.2018.204040

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