Early view

Mar 16, 2023

Editorials
Article

E3-ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia (371 Online Views)

Kai Zhang, Dingdong Liu, Yafei Li, Zhencan Shi, Jun Guo, Chengjiang Gao, Hu Wang, Zhenyu Ju, Daojun Diao

https://doi.org/10.3324/haematol.2022.281955

Editorials
Article

Low T-cell proportion in the tumor microenvironment is associated with immune escape and poor survival in diffuse large B-cell lymphoma (442 Online Views)

Joo Y. Song, Mary Nwangwu, Ting-Fang He, Weiwei Zhang, Hany Meawad, Victoria Bedell, Joyce Murata-Collins, Pamela Skrabek, Michel R. Nasr, David Scott, James Godfrey, Peter Lee, Wing C. Chan, Dennis D. Weisenburger, Anamarija M. Perry, Alex F. Herrera

https://doi.org/10.3324/haematol.2022.282265

Articles

Severity and burden of sickle cell disease in France: a nationwide realworld study (62 Online Views)

Valentine Brousse, Francoise Bernaudin, Asma Melaine, Melanie Goguillot, Meghan Gallagher, Steve Benard, Anoosha Habibi

https://doi.org/10.3324/haematol.2022.282098

Pax transactivation domain-interacting protein is required for preserving hematopoietic stem cell quiescence via regulating lysosomal activity (84 Online Views)

Tong Zhang, Manman Cui, Yashu Li, Ying Cheng, Zhuying Gao, Jing Wang, Tiantian Zhang, Guoqiang Han, Rong Yin, Peipei Wang, Wen Tian, Weidong Liu, Jin Hu, Yuhua Wang, Zheming Liu, Haojian Zhang

https://doi.org/10.3324/haematol.2022.282224

Artificial intelligence to empower diagnosis of myelodysplastic syndromes by multiparametric flow cytometry (89 Online Views)

Valentin Clichet, Delphine Lebon, Nicolas Chapuis, Jaja Zhu, Valérie Bardet, Jean-Pierre Marolleau, Loïc Garçon, Alexis Caulier, Thomas Boyer

https://doi.org/10.3324/haematol.2022.282370

Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells (90 Online Views)

Daniel W. Hagey, Egle Kvedaraite, Mira Akber, André Görgens, Joman Javadi, Tatiana von Bahr Greenwood, Caroline Björklund, Selma Olsson Åkefeldt, Tova Hannegård-Hamrin, Henrik Arnell, Katalin Dobra, Nikolas Herold, Mattias Svensson, Samir EL Andaloussi, Jan-Inge Henter, Magda Lourda

https://doi.org/10.3324/haematol.2022.282638

Letters to the Editor

Mar 9, 2023

Editorials
Article

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy (363 Online Views)

Francesca Arruga, Marta Rubin, Despoina Papazoglou, Andrea Iannello, Nikolaos Ioannou, Riccardo Moia, Davide Rossi, Gianluca Gaidano, Marta Coscia, Luca Laurenti, Giovanni D’Arena, John N. Allan, Richard R. Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio

https://doi.org/10.3324/haematol.2022.282177

Editorials
Letter to the Editor

Articles

Gonadal function in pediatric Fanconi anemia patients treated with hematopoietic stem cell transplant (143 Online Views)

Jane Koo, Ines Grom-Mansencal, Jonathan C. Howell, Julie M. Rios, Parinda A. Mehta, Stella M. Davies, Kasiani C. Myers

https://doi.org/10.3324/haematol.2022.282094

Impact of central nervous system involvement in adult patients with Philadelphia-negative acute lymphoblastic leukemia: a GRAALL-2005 study (108 Online Views)

Corentin Orvain, Sylvain Chantepie, Xavier Thomas, Martine Escofrre-Barbe, Francoise Huguet, Yohan Desbrosses, Gaelle Guillerm, Madalina Uzunov, Thibaut Leguay, Sarah Barbieux, Norbert Vey, Patrice Chevallier, Jean-Valere Malfuson, Stephane Lepretre, Michael Baumann, Murat Aykut, Abdelaziz Chaib, Magalie Joris, Hacene Zerazhi, Georg Stussi, Jacques Chapiro, Celine Berthon, Caroline Bonmati, Eric Jourdan, Diana Carp, Amb roise Marcais, Maria-Pilar Gallego-Hernanz, Iona Vaida, Karin Bilger, Alban Villate, Florence Pasquier, Yves Chalandon, Sebastien Maury, Veronique Lheritier, Norbert Ifrah, Herve Dombret, Nicolas Boissel, Mathilde Hunault-Berger.

https://doi.org/10.3324/haematol.2022.282332

Letters to the Editor

Post-transplantation Burkitt lymphoma: a retrospective study of 55 patients (121 Online Views)

Pierre Walczak, Sylvain Choquet, Jacques Dantal, David Boutboul, Felipe Suarez, Marine Baron, Veronique Morel, Thomas Cluzeau, Mohamed Touati, Michelle Elias, Emmanuel Bachy, Emmanuelle Nicolas-Virelizier, Roch Houot, Geoffroy Venton, Caroline Jacquet, Marie-Pierre Moles-Moreau, Fabrice Jardin, Eric Durot, Noureddine Balegroune, Laure Ecotiere, Romain Guieze, Nassim Kamar, Loic Ysebaert, Lionel Couzi, Hugo Gonzalez, Louise Roulin, Kevin Ou, Sophie Caillard, Heiner Zimmermann, Ralf Ulrich Trappe, Damien Roos-Weil

https://doi.org/10.3324/haematol.2022.282297

The oncogenetic landscape and clinical impact of BCL11B alterations in adult and pediatric T-cell acute lymphoblastic leukemia (156 Online Views)

Marie Emilie Dourthe, Guillaume P. Andrieu, Amandine Potier, Estelle Balducci, Julie Guerder, Mathieu Simonin, Lucien Courtois, Arnaud Petit, Elizabeth Macintyre, Nicolas Boissel, André Baruchel, Vahid Asnafi

https://doi.org/10.3324/haematol.2022.282605

Mar 2, 2023

Review Articles

Articles

RNA helicase DHX15 exemplifies a unique dependency in acute leukemia (334 Online Views)

Hao Guo, Jin Xu, Peiqi Xing, Qilong Li, Donghai Wang, Chao Tang, Bruno Palhais, Juliette Roels, Jiaxu Liu, Sa Pan, Jinyan Huang, Zhaoqi Liu, Ping Zhu, Tom Taghon, Guoliang Qing, Pieter Van Vlierberghe, Hudan Liu

https://doi.org/10.3324/haematol.2022.282066

CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation (461 Online Views)

Jian Bai, Fan Fan, Chunchen Gao, Shaohua Li, Wei Li, Tiaoxia Wei, Shilin Cheng, Jinmin Yu, Chao Zheng, Junlong Zhao, Linru Zou, Lei Feng, Jing Yi, Hongyan Qin

https://doi.org/10.3324/haematol.2022.282192

The Geriatric Prognostic Index: a clinical prediction model for survival of older diffuse large B-cell lymphoma patients treated with standard immunochemotherapy (227 Online Views)

Kathrine T. Isaksen, Renate Galleberg, Maria Adele Mastroianni, Marit Rinde, Leiv Sindre Rusten, Dlawer Barzenje, Frode Ramslien, Oystein Fluge, Marit Slaaen, Peter Meyer, Knut Liestol, Erlend B. Smeland, Ole Christian Lingjarde, Harald Holte, Marianne Brodtkorb

https://doi.org/10.3324/haematol.2022.282289

PARP1 and POLD2 as prognostic biomarkers for multiple myeloma in autologous stem cell transplant (168 Online Views)

Melissa Thomas, Junan Li, Kevan King, Avinash K Persaud, Ernest Duah, Zachary Vangundy, Craig C. Hofmeister, Jatinder K. Lamba, Aik Choon Tan, Brooke L. Fridley, Ming J. Poi, Nathan D. Seligson

https://doi.org/10.3324/haematol.2022.282399

Letters to the Editor

KMT2A partner genes in infant acute lymphoblastic leukemia have prognostic significance and correlate with age, white blood cell count, sex, and central nervous system involvement: a Children’s Oncology Group P9407 trial study (153 Online Views)

Blaine W. Robinson, John A. Kairalla, Meenakshi Devidas, Andrew J. Carroll, Richard C. Harvey, Nyla A. Heerema, Cheryl L. Willman, Amanda R. Ball, Elliot C. Woods, Nancy C. Ballantyne, Karen A. Urtishak, Frederick G. Behm, Gregory H. Reaman, Joanne M. Hilden, Bruce M. Camitta, Naomi J. Winick, Jeanette Pullen, William L. Carroll, Stephen P. Hunger, ZoAnn E. Dreyer, Carolyn A. Felix

https://doi.org/10.3324/haematol.2022.281552

B-lineage acute lymphoblastic leukemia causes cell autonomous defects in long-term hematopoietic stem cell function. (94 Online Views)

Christina T Jensen, Josefine Åhsberg, Johanna Tingvall-Gustafsson, Rajesh Somasundaram, Stefan Lang, Jonas Ungerbäck, Anna Porwit, Shamit Soneji, Mikael Sigvardsson

https://doi.org/10.3324/haematol.2022.282430

Outcome of patients with acute myeloid leukemia following failure of frontline venetoclax plus hypomethylating agent therapy (216 Online Views)

Naseema Gangat, Rimal Ilyas, Isla M Johnson, Kristen McCullough, Aref Al-Kali, Hassan B Alkhateeb, Kebede H Begna, Abhishek Mangaonkar, Mark R Litzow, William Hogan, Mithun Shah, Mrinal M Patnaik, Animesh Pardanani, Ayalew Tefferi

https://doi.org/10.3324/haematol.2022.282677

Case Reports

Feb 23, 2023

Editorials
Article

Effects of nandrolone decanoate on telomere length and clinical outcome in patients with telomeropathies: a prospective trial (616 Online Views)

Diego V. Clé, Luiz Fernando B. Catto, Fernanda Gutierrez-Rodrigues, Flávia S. Donaires, Andre L. Pinto, Barbara A. Santana, Luiz Guilherme Darrigo, Elvis T. Valera, Marcel Koenigkam-Santos, José Baddini-Martinez, Neal S. Young, Edson Z. Martinez, Rodrigo T. Calado

https://doi.org/10.3324/haematol.2022.281808

Editorials
Article

High rate of durable responses with undetectable minimal residual disease with frontline venetoclax and rituximab in young and fit patients with chronic lymphocytic leukemia and an adverse biologic profile: results of the GIMEMA phase II LLC1518 - 'Veritas' study (667 Online Views)

Francesca R. Mauro, Irene Della Starza, Monica Messina, Gianluigi Reda, Livio Trentin, Marta Coscia, Paolo Sportoletti, Lorella Orsucci, Valentina Arena, Gloria Margiotta Casaluci, Roberto Marasca, Roberta Murru, Luca Laurenti, Fiorella Ilariucci, Caterina Stelitano, Donato Mannina, Massimo Massaia, Gian Matteo Rigolin, Lydia Scarfò, Monia Marchetti, Luciano Levato, Monica Tani, Annalisa Arcari, Gerardo Musuraca, Marina Deodato, Piero Galieni, Valeria Belsito Patrizi, Daniela Gottardi, Anna Marina Liberati, Annamaria Giordano, Maria Chiara Molinari, Daniela Pietrasanta, Veronica Mattiello, Andrea Visentin, Candida Vitale, Francesco Albano, Antonino Neri, Lucia Anna De Novi, Maria Stefania De Propris, Mauro Nanni, Ilaria Del Giudice, Anna Guarini, Paola Fazi, Marco Vignetti, Alfonso Piciocchi, Antonio Cuneo, Robin Foà

https://doi.org/10.3324/haematol.2022.282116

Articles

Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance (470 Online Views)

Allison Barraclough, James T. England, Diego Villa, Joel Wight, Greg Hapgood, Jason Conn, Nicole Wong Doo, Eric Wenlong Li, Michael Gilbertson, Briony Shaw, Mark J. Bishton, Malik Saeed, Sumita Ratnasingam, Chathuri Abeyakoon, Geoff Chong, Shin Hnin Wai, Matthew Ku, Hui-Peng Lee, Kathryn Fleming, Constantine Tam, Genevieve Douglas, Chan Y. Cheah, Zi Yun Ng, Tukten Rolfe, Anthony K Mills, Nada Hamad, Helen Cashman, Mary Gleeson, Manjunath Narayana, Eliza A. Hawkes

https://doi.org/10.3324/haematol.2022.281375

Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia (505 Online Views)

Eline J.M. Bertrums, Jenny L. Smith, Lauren Harmon, Rhonda E. Ries, Yi-Cheng J. Wang, Todd A. Alonzo, Andrew J. Menssen, Karen M. Chisholm, Amanda R. Leonti, Katherine Tarlock, Fabiana Ostronoff, Era L. Pogosova-Agadjanyan, Gertjan J.L. Kaspers, Henrik Hasle, Michael Dworzak, Christiane Walter, Nora Muhlegger, Cristina Morerio, Laura Pardo, Betsy Hirsch, Susana Raimondi, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Jason E. Farrar, Derek Stirewalt, Xiaotu Ma, Tim I. Shaw, Scott N. Furlan, Lisa Eidenschink Brodersen, Michael R. Loken, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Timothy J. Triche, Bianca F. Goemans, Soheil Meshinchi

https://doi.org/10.3324/haematol.2022.281653

Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia (250 Online Views)

Sabine Kayser, David Martínez-Cuadrón, Rebeca Rodriguez-Veiga, Mathias Hänel, Mar Tormo, Kerstin Schäfer-Eckart, Carmen Botella, Friedrich Stölzel, Teresa Bernal del Castillo, Ulrich Keller, Carlos Rodriguez-Medina, Gerhard Held, Maria-Luz Amigo, Christoph Schliemann, Mercedes Colorado, Martin Kaufmann, Manuel Barrios Garcia, Stefan W. Krause, Martin Görner, Edgar Jost, Björn Steffen, Sven Zukunft, Uwe Platzbecker, Anthony D. Ho, Claudia D. Baldus, Hubert Serve, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Pau Montesinos, Christoph Röllig, Richard F. Schlenk

https://doi.org/10.3324/haematol.2022.282127

Letters to the Editor

Impact of vincristine dose reduction on outcomes of patients with aggressive B-cell lymphoma treated with (R) - CHOP (304 Online Views)

Moritz Bewarder, Dominic Kaddu-Mulindwa, Igor Age Kos, Vadim Lesan, Gerhard Held, Viola Poeschel, Lorenz Thurner, Joerg Thomas Bittenbring, Norbert Schmitz, Lorenz Truemper, Michael Pfreundschuh, Konstantinos Christofyllakis, Markus Loeffler, Bettina Altmann, Marita Ziepert

https://doi.org/10.3324/haematol.2022.282126

Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency (313 Online Views)

Oskar Marin-Bejar, Damia Romero-Moya, Javier Rodriguez-Ubreva, Maximiliano Distefano, Francesca Lessi, Paolo Aretini, Alessandro Liquori, Julio Castaño, Emilia Kozyra, Lili Kotmayer, Clara Bueno, José Cervera, José Carlos Rodriguez-Gallego, Josep F Nomdedeu, Laura Murillo-Sanjuán, Cristina Díaz de Heredia, Antonio Pérez-Martinez, Félix López-Cadenas, Carolina Martínez-Laperche, Nieves Dorado-Herrero, Francisco M Marco, Felipe Prósper, Pablo Menendez, David Valcárcel, Esteban Ballestar, Csaba Bödör, Anna Bigas, Albert Catalá, Marcin W Wlodarski, Alessandra Giorgetti

https://doi.org/10.3324/haematol.2022.282305

Feb 16, 2023

Editorials
Article

Development and manufacturing of novel locally produced anti-BCMA CAR-T cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results (2086 Online Views)

Nathalie Asherie, Shlomit Kfir-Erenfeld, Batia Avni, Miri Assayag, Tatyana Dubnikov, Nomi Zalcman, Eyal Lebel, Eran Zimran, Adir Shaulov, Marjorie Pick, Yael Cohen, Irit Avivi, Cyrille Cohen, Moshe E. Gatt, Sigal Grisariu, Polina Stepensky

https://doi.org/10.3324/haematol.2022.281628

Editorials
Article

Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia (1237 Online Views)

Heikki Kuusanmäki, Sari Kytölä, Ida Vänttinen, Tanja Ruokoranta, Amanda Ranta, Jani Huuhtanen, Minna Suvela, Alun Parsons, Annasofia Holopainen, Anu Partanen, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Imre Västrik, Olli Dufva, Sanna Siitonen, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Mika Kontro

https://doi.org/10.3324/haematol.2022.281692

Editorials
Article

CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine (478 Online Views)

Theodoros Karantanos, Patric Teodorescu, Marios Arvanitis, Brandy Perkins, Tania Jain, Amy E. DeZern, W. Brian Dalton, Ilias Christodoulou, Bogdan C. Paun, Ravi Varadhan, Christopher Esteb, Trivikram Rajkhowa, Challice Bonifant, Lukasz P. Gondek, Mark J. Levis, Srinivasan Yegnasubramanian, Gabriel Ghiaur, Richard J. Jones

https://doi.org/10.3324/haematol.2022.281444

Review Articles

Articles

Integrated genetic and clinical prognostic factors for aggressive adult T-cell leukemia/lymphoma (499 Online Views)

Takuro Kameda, Keisuke Kataoka, Ayako Kamiunten, Michihiro Hidaka, Hiroaki Miyoshi, Nobuaki Nakano, Kisato Nosaka, Makoto Yoshimitsu, Jun-ichirou Yasunaga, Yasunori Kogure, Kotaro Shide, Masaharu Miyahara, Takashi Sakamoto, Keiichi Akizuki, Tomonori Hidaka, Yoko Kubuki, Junji Koya, Noriaki Kawano, Kiyoshi Yamashita, Hiroshi Kawano, Takanori Toyama, Kouichi Maeda, Kosuke Marutsuka, Yoshitaka Imaizumi, Koji Kato, Takeshi Sugio, Masahito Tokunaga, Yukie Tashiro, Akifumi Takaori-Kondo, Yasushi Miyazaki, Koichi Akashi, Kenji Ishitsuka, Masao Matsuoka, Koichi Ohshima, Toshiki Watanabe, Akira Kitanaka, Atae Utsunomiya, Seishi Ogawa, Kazuya Shimoda

https://doi.org/10.3324/haematol.2022.281510

Automated production of specific T cells for treatment of refractory viral infections after allogeneic stem cell transplantation (176 Online Views)

Amadeus T Heinz, Friso G.J. Calkoen, Alexander Derbich, Lea Miltner, Christian Seitz, Michaela Doering, Christiane Braun, Daniel Atar, Michael Schumm, Florian Heubach, Anne-Marie Arendt, Ansgar Schulz, Friedhelm R Schuster, Roland Meisel, Brigitte Strahm, Juergen Finke, Beatrice Heineking, Susanne Stetter, Gerda Silling, Daniel Stachel, Bernd Gruhn, Klaus-Michael Debatin, Juergen Foell, Johannes H Schulte, Wilhelm Woessmann, Christine Mauz-Körholz, Johanna Tischer, Tobias Feuchtinger, Rupert Handgretinger, Peter Lang

https://doi.org/10.3324/haematol.2022.281996

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis (209 Online Views)

Francesca Basso-Valentina, Alessandro Donada, Vladimir T Manchev, Manuel Lisetto, Nathalie Balayn, Jean Edouard Martin, Delphine Muller, Cecilia Paola Marin Oyarzun, Hélène Duparc, Brahim Arkoun, Alessandro Cumin, Lionel Faivre, Nathalie Droin, Ida Biunno, Alessandro Pecci, Alessandra Balduini, Najet Debili, Iléana Antony-Debré, Caroline Marty, William Vainchenker, Isabelle Plo, Remi Favier, Hana Raslova

https://doi.org/10.3324/haematol.2022.282049

Letters to the Editor

Favorable pharmacokinetics and pharmacodynamics properties of Gilteritinib in cerebrospinal fluid: a potential effective treatment in relapsing meningeal acute myeloid leukaemia FLT3-ITD patients (259 Online Views)

Nicolas Vignal, Loïs Kelly, Etienne Lengline, Aurélie Cabannes-Hamy, Justine Siavellis, David Ghez, Hélène Sauvageon, Thorsten Braun, Evelyne Jacqz-Aigrain, Milena Kohn, Philippe Rousselot, Alexandre Puissant, Emmanuel Raffoux, Samia Mourah, Lauriane Goldwirt

https://doi.org/10.3324/haematol.2022.282596

Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice (113 Online Views)

Alessandro Mattè, Penelope A. Kosinski, Enrica Federti, Lenny Dang, Antonio Recchiuti, Roberta Russo, Angela Siciliano, Veronica Riccardi, Anne Janin, Matteo Mucci, Christophe Leboeuf, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi

https://doi.org/10.3324/haematol.2022.282614

Blast phase myeloproliferative neoplasm with prior exposure to ruxolitinib: comparative analysis of mutations and survival (156 Online Views)

Maymona G. Abdelmagid, Aref Al-Kali, Kebede H. Begna, William J. Hogan, Mark R. Litzow, Farah Fleti, Abhishek A. Mangaonkar, Mrinal S. Patnaik, Michelle A. Elliott, Hassan Alkhateeb, Min Shi, Matthew T. Howard, Kaaren K. Reichard, Rhett P. Ketterling, Mithun Shah, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi

https://doi.org/10.3324/haematol.2022.282627

Feb 9, 2023

Articles

Results from a phase I/II trial of cusatuzumab combined with azacitidine in patients with newly diagnosed acute myeloid leukemia who are ineligible for intensive chemotherapy (627 Online Views)

Thomas Pabst, Norbert Vey, Lionel Adès, Ulrike Bacher, Mario Bargetzi, Samson Fung, Gianluca Gaidano, Domenica Gandini, Anna Hultberg, Amy Johnson, Xuewen Ma, Rouven Müller, Kerri Nottage, Cristina Papayannidis, Christian Recher, Carsten Riether, Priya Shah, Jeffrey Tryon, Liang Xiu, Adrian F. Ochsenbein

https://doi.org/10.3324/haematol.2022.281563

General condition and comorbidity of long-term survivors of adult acute lymphoblastic leukemia (176 Online Views)

Nicola Gökbuget, Kristina Ihrig, Michael Stadler, Matthias Stelljes, Ahmed Elmaagli, Michael Starck, Simon Raffel, Andrea Stoltefuss, Andreas Viardot, Karl-Anton Kreuzer, Daniela Heidenreich, Andrea Renzelmann, Ralph Wäsch, Max S. Topp, Barbara Ritter, Peter Reimer, Joachim Beck, Jörg Westermann, Knut Wendelin, Nael Alakel, Maher Hanoun, Hubert Serve, Dieter Hoelzer

https://doi.org/10.3324/haematol.2022.281820

Association between the choice of the conditioning regimen and outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis (747 Online Views)

Guru Subramanian Guru Murthy, Soyoung Kim, Noel Estrada-Merly, Muhammad Bilal Abid, Mahmoud Aljurf, Amer Assal, Talha Badar, Sherif M. Badawy, Karen Ballen, Amer Beitinjaneh, Jan Cerny, Saurabh Chhabra, Zachariah DeFilipp, Bhagirathbhai Dholaria, Miguel Angel Diaz Perez, Shatha Farhan, Cesar O. Freytes, Robert Peter Gale, Siddhartha Ganguly, Vikas Gupta, Michael R. Grunwald, Nada Hamad, Gerhard C. Hildebrandt, Yoshihiro Inamoto, Tania Jain, Omer Jamy, Mark Juckett, Matt Kalaycio, Maxwell M. Krem, Hillard M. Lazarus, Mark Litzow, Reinhold Munker, Hemant S. Murthy, Sunita Nathan, Taiga Nishihori, Guillermo Ortí, Sagar S. Patel, Marjolein van der Poel, David A. Rizzieri, Bipin N. Savani, Sachiko Seo, Melhem Solh, Leo F. Verdonck, Baldeep Wirk, Jean A. Yared, Ryotaro Nakamura, Betul Oran, Bart Scott, Wael Saber

https://doi.org/10.3324/haematol.2022.281958

Sialylation regulates migration in chronic lymphocytic leukemia (289 Online Views)

Alessandro Natoni, Marina Cerreto, Maria Stefania De Propris, Ilaria Del Giudice, Roberta Soscia, Nadia Peragine, Stefania Intoppa, Maria Laura Milani, Anna Guarini, Robin Foà

https://doi.org/10.3324/haematol.2022.281999

Letters to the Editor

Midostaurin in addition to intensive chemotherapy in acute myeloid leukemia with t(8;21) and KIT and/or FLT3-ITD mutations: results of the SAL MIDOKIT trial (328 Online Views)

Leo Ruhnke, Christoph Röllig, Sylvia Herold, Tim Sauer, Christian H. Brandts, Björn Steffen, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Albrecht Reichle, Sebastian Scholl, Andreas Neubauer, Jan-Henrik Mikesch, Johannes Schetelig, Friedrich Stölzel, Michael Kramer, Annett Haake, Julia Frimmel, Alwin Krämer, Richard Schlenk, Uwe Platzbecker, Hubert Serve, Claudia D. Baldus, Carsten Müller-Tidow, Daniela Aust, Martin Bornhäuser, Gerhard Ehninger, Christian Thiede

https://doi.org/10.3324/haematol.2022.281636

Feb 2, 2023

Editorials
Article

Adipocytes control haematopoiesis and inflammation through CD40 signaling (468 Online Views)

Myrthe E. Reiche, Kikkie Poels, Laura A. Bosmans, Winnie G. Vos, Claudia M. van Tiel, Marion J.J. Gijbels, Suzanne A.B.M. Aarts, Myrthe den Toom, Linda Beckers, Christian Weber, Dorothee Atzler, Patrick C.N. Rensen, Sander Kooijman, Esther Lutgens

https://doi.org/10.3324/haematol.2022.281482

Articles

Complement protein C3a enhances adaptive immune responses towards FVIII products (377 Online Views)

Eva Ringler, Samira Ortega Iannazzo, Jessica Herzig, Lisa M. Weiss, Martina Anzaghe, Lilija Miller, Zoe Waibler

https://doi.org/10.3324/haematol.2022.281762

Clonal hematopoiesis in the donor does not adversely affect long-term outcomes following allogeneic hematopoietic stem cell transplantation: result from 13-year followup (467 Online Views)

Kyoung Ha Kim, TaeHyung Kim, Igor Novitzky-Basso, Hyewon Lee, Youngseok Yoo, Jae-Sook Ahn, Ivan Pasic, Arjun Law, Wilson Lam, Fotios V. Michelis, Armin Gerbitz, Auro Viswabandya, Jeffrey Lipton, Rajat Kumar, Jonas Mattsson, Zhaolei Zhang, Nathali Kaushansky, Yardena Brilon, Noa Chapal-Ilani, Tamir Biezuner, Liran I Shlush, Dennis Dong Hwan Kim

https://doi.org/10.3324/haematol.2022.281806

Molecular response in newly diagnosed chronic-phase chronic myeloid leukemia: prediction modeling and pathway analysis (389 Online Views)

Jerald P. Radich, Matthew Wall, Susan Branford, Catarina D. Campbell, Shalini Chaturvedi, Daniel J. DeAngelo, Michael Deininger, Justin Guinney, Andreas Hochhaus, Timothy P Hughes, Hagop M. Kantarjian, Richard A. Larson, Sai Li, Rodrigo Maegawa, Kaushal Mishra, Vanessa Obourn, Javier Pinilla-Ibarz, Das Purkayastha, Islam Sadek, Giuseppe Saglio, Alok Shrestha, Brian S. White, Brian J. Druker

https://doi.org/10.3324/haematol.2022.281878

Transcriptome analysis in acute gastrointestinal graft-versus host disease reveals a unique signature in children and shared biology with pediatric inflammatory bowel disease. (233 Online Views)

Pooja Khandelwal, Dana T Lounder, Allison Bartlett, Yael Haberman, Anil G. Jegga, Sudhir Ghandikota, Jane Koo, Nathan Luebbering, Daniel Leino, Sheyar Abdullah, Michaela Loveless, Phillip Minar, Kelly Lake, Bridget Litts, Rebekah Karns, Adam S. Nelson, Lee A. Denson, Stella M. Davies

https://doi.org/10.3324/haematol.2022.282035

High-dose carfilzomib achieves superior anti-tumor activity over lowdose and recaptures response in relapsed/refractory multiple myeloma resistant to low-dose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex (293 Online Views)

Xiang Zhou, Andrej Besse, Jessica Peter, Maximilian Johannes Steinhardt, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Xianghui Xiao, Hannah Hornburger, Larissa Haertle, Max Mendez Lopez, Umair Munawar, Angela Riedel, Seungbin Han, Elmer Maurits, Herman S. Overkleeft, Bogdan Florea, Hermann Einsele, K. Martin Kortüm, Christoph Driessen, Lenka Besse, Leo Rasche

https://doi.org/10.3324/haematol.2022.282225

Somatic genetic alterations predict haematological progression in GATA2 deficiency (397 Online Views)

Laetitia Largeaud, Matthew Collin, Nils Monselet, Francois Vergez, Vincent Fregona, Lise Larcher, Pierre Hirsch, Nicolas Duployez, Audrey Bidet, Isabelle Luquet, Jacinta Bustamante, Stephanie Dufrechou, Nais Prade, Marie Nolla, Camille Hamelle, Suzanne Tavitian, Christophe Habib, Mateo Meynier, Christine Bellanne-Chantelot, Jean Donadieu, Flore Sicre de Fontbrune, Claire Fieschi, Alina Ferster, Francois Delhommeau, Eric Delabesse, Marlene Pasquet

https://doi.org/10.3324/haematol.2022.282250

Letters to the Editor

Case Reports

H syndrome mimicking Erdheim Chester disease : new entity and therapeutic perspectives (246 Online Views)

Hippolyte Lequain, Mathieu Gerfaud-Valentin, Jean-François Emile, Yann-Gaël Gangloff, Guilaine Boursier, Christophe Deligny, Guillaume Le Guenno, Juliet Tantot, Julie Valantin, Lea Savey, Claude Bachmeyer, Yvan Jamilloux, Laurent Schaeffer, Pascal Leblanc, Pascal Sève

https://doi.org/10.3324/haematol.2022.282040

Jan 26, 2023

Editorials
Article

Contribution of fetal microchimeric cells to maternal wound healing in sickle cell ulcers (286 Online Views)

Mansour Alkobtawi, Maria Sbeih, Karim Souaid, Qui Trung Ngô, Dany Nassar, Hugo Arbes, Henri Guillet, Anoosha Habibi, Pablo Bartolucci, Mathieu Castela, Sélim Aractingi, Bénédicte Oulès

https://doi.org/10.3324/haematol.2022.281140

Review Articles

Articles

Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia (419 Online Views)

Holly Pariury, Joshua Fandel, Stefanie Bachl, Kenny K. Ang, Sarine Markossian, Chris G. Wilson, Benjamin S. Braun, Bogdan Popescu, Margo Wohlfeil, Kyle Beckman, Simayijiang Xirenayi, Ritu P. Roy, Adam B. Olshen, Catherine Smith, Michelle R. Arkin, Mignon L. Loh, Ernesto Diaz-Flores

https://doi.org/10.3324/haematol.2022.281443

Comprehensive in silico and functional studies for classification of EPAS1/HIF2A genetic variants identified in patients with erythrocytosis (271 Online Views)

Valéna Karaghiannis, Darko Maric, Céline Garrec, Nada Maaziz, Alexandre Buffet, Loïc Schmitt, Vincent Antunes, Fabrice Airaud, Bernard Aral, Amandine Le Roy, Sébastien Corbineau, Lamisse Mansour-Hendili, Valentine Lesieur, Antoine Rimbert, Fabien Laporte, Marine Delamare, Minke Rab, Stéphane Bézieau, Bruno Cassinat, Frédéric Galacteros, Anne-Paule Gimenez-Roqueplo, Nelly Burnichon, Holger Cario, Richard van Wijk, Celeste Bento, François Girodon, David Hoogewijs, Betty Gardie

https://doi.org/10.3324/haematol.2022.281698

Duality of Nrf2 in iron-overload cardiomyopathy (248 Online Views)

Enrica Federti, Francesca Vinchi, Iana Iatcenko, Alessandra Ghigo, Alessandro Matte, Serge Cedrick Mbiandjeu Toya, Angela Siciliano, Deborah Chiabrando, Emanuela Tolosano, Steven Zebulon Vance, Veronica Riccardi, Immacolata Andolfo, Manuela Iezzi, Alessia Lamolinara, Achille Iolascon, Lucia De Franceschi

https://doi.org/10.3324/haematol.2022.281995

Therapeutic potential of fetal liver cells transplantation in hemophilia A mice (285 Online Views)

Simone Merlin, Saicharan Akula, Alessia Cottonaro, Tamara Garcia-Leal, Luis Javier Serrano, Ester Borroni, Vakhtang Kalandadze, Rocio Galiano, Chiara Borsotti, Antonio Liras, María José Sanchez, Antonia Follenzi

https://doi.org/10.3324/haematol.2022.282001

Differential inhibition of T cell receptor and STAT5 signalling pathways determines the immunomodulatory effects of dasatinib in chronic phase chronic myeloid leukemia (307 Online Views)

Patrick Harrington, Richard Dillon, Deepti Radia, Philippe Rousselot, Donal P. McLornan, Mark Ong, Anna Green, Alessandro Verde, Farzana Hussain, Kavita Raj, Shahram Kordasti, Claire Harrison, Hugues de Lavallade

https://doi.org/10.3324/haematol.2022.282005

Tislelizumab with gemcitabine and oxaliplatin in patients with relapsed or refractory classic Hodgkin lymphoma: a multicenter phase II trial (665 Online Views)

Kaiyang Ding, Hailing Liu, Jie Ma, Haiyan Yang, Lei Cao, Huihan Wang, Hongling Peng, Wei Shi, Xiaoli Zhao, Wei Wu, Huayuan Zhu, Jianyong Li, Lei Fan

https://doi.org/10.3324/haematol.2022.282266

Letters to the Editor

Case Reports

Omalizumab alleviates pruritus in myeloproliferative neoplasms (154 Online Views)

Anna Ravn Landtblom, Johanna Ungerstedt, Anette Hedlund, Magnus Tobiasson, Stefan Deneberg, Martin Jädersten

https://doi.org/10.3324/haematol.2022.281639

Jan 19, 2023

Articles

The IgG-degrading enzyme, Imlifidase, restores the therapeutic activity of FVIII in inhibitor-positive hemophilia A mice (472 Online Views)

Melissa Bou-Jaoudeh, Sandrine Delignat, Victoria Daventure, Jan Astermark, Hervé Lévesque, Jordan D. Dimitrov, Claire Deligne, Valérie Proulle, Sébastien Lacroix-Desmazes

https://doi.org/10.3324/haematol.2022.281895

The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy (363 Online Views)

Francesca Arruga, Marta Rubin, Despoina Papazoglou, Andrea Iannello, Nikolaos Ioannou, Riccardo Moia, Davide Rossi, Gianluca Gaidano, Marta Coscia, Luca Laurenti, Giovanni D’Arena, John N. Allan, Richard R. Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio

https://doi.org/10.3324/haematol.2022.282177

Letters to the Editor

Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors (491 Online Views)

Gregory W. Roloff, Frank Wen, Aubrianna Ramsland, Andrew S. Artz, Satyajit Kosuri, Wendy Stock, Olatoyosi Odenike, Richard A. Larson, Hongtao Liu, Lucy A. Godley, Michael J. Thirman, Anand A. Patel, Christopher K. Daugherty, Adam S. DuVall, Mariam T. Nawas, Emily Dworkin, Geoffrey D. Wool, Sandeep Gurbuxani, Carrie Fitzpatrick, Jeremy P. Segal, Peng Wang, Michael W. Drazer

https://doi.org/10.3324/haematol.2022.282148

Treatment patterns and real-world effectiveness of rituximab maintenance in older patients with mantle cell lymphoma: a population-based analysis (724 Online Views)

Mengyang Di, Jessica B. Long, Shalin K. Kothari, Tarsheen Sethi, Amer M. Zeidan, Nikolai A. Podoltsev, Rory M. Shallis, Rong Wang, Xiaomei Ma, Scott F. Huntington

https://doi.org/10.3324/haematol.2022.282252

TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia (208 Online Views)

Clara Bueno, Alba Martínez, Paola Alejandra Romecin, Samanta Romina Zanetti, Ricky Tirtakusuma, Eulalia Genesca, Mireia Camós, Manuel Ramírez-Orellana, Eduardo Anguita, Paola Ballerini, Franco Locatelli, José Luis Fuster, Pablo Menéndez

https://doi.org/10.3324/haematol.2022.282394

Jan 12, 2023

Review Articles

Articles

TAL1 activation in T-Cell acute lymphoblastic leukemia: A novel oncogenic 3’ neoenhancer (442 Online Views)

Charlotte Smith, Ashish Goyal, Dieter Weichenhan, Eric Allemand, Anand Mayakonda, Umut Toprak, Anna Riedel, Estelle Balducci, Manisha Manojkumar, Anastasija Pejkovska, Oliver Mücke, Etienne Sollier, Ali Bakr, Kersten Breuer, Pavlo Lutsik, Olivier Hermine, Salvatore Spicuglia, Vahid Asnafi, Christoph Plass, Aurore Touzart

https://doi.org/10.3324/haematol.2022.281583

E3-ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia (371 Online Views)

Kai Zhang, Dingdong Liu, Yafei Li, Zhencan Shi, Jun Guo, Chengjiang Gao, Hu Wang, Zhenyu Ju, Daojun Diao

https://doi.org/10.3324/haematol.2022.281955

High rate of durable responses with undetectable minimal residual disease with frontline venetoclax and rituximab in young and fit patients with chronic lymphocytic leukemia and an adverse biologic profile: results of the GIMEMA phase II LLC1518 - 'Veritas' study (667 Online Views)

Francesca R. Mauro, Irene Della Starza, Monica Messina, Gianluigi Reda, Livio Trentin, Marta Coscia, Paolo Sportoletti, Lorella Orsucci, Valentina Arena, Gloria Margiotta Casaluci, Roberto Marasca, Roberta Murru, Luca Laurenti, Fiorella Ilariucci, Caterina Stelitano, Donato Mannina, Massimo Massaia, Gian Matteo Rigolin, Lydia Scarfò, Monia Marchetti, Luciano Levato, Monica Tani, Annalisa Arcari, Gerardo Musuraca, Marina Deodato, Piero Galieni, Valeria Belsito Patrizi, Daniela Gottardi, Anna Marina Liberati, Annamaria Giordano, Maria Chiara Molinari, Daniela Pietrasanta, Veronica Mattiello, Andrea Visentin, Candida Vitale, Francesco Albano, Antonino Neri, Lucia Anna De Novi, Maria Stefania De Propris, Mauro Nanni, Ilaria Del Giudice, Anna Guarini, Paola Fazi, Marco Vignetti, Alfonso Piciocchi, Antonio Cuneo, Robin Foà

https://doi.org/10.3324/haematol.2022.282116

Low T-cell proportion in the tumor microenvironment is associated with immune escape and poor survival in diffuse large B-cell lymphoma (442 Online Views)

Joo Y. Song, Mary Nwangwu, Ting-Fang He, Weiwei Zhang, Hany Meawad, Victoria Bedell, Joyce Murata-Collins, Pamela Skrabek, Michel R. Nasr, David Scott, James Godfrey, Peter Lee, Wing C. Chan, Dennis D. Weisenburger, Anamarija M. Perry, Alex F. Herrera

https://doi.org/10.3324/haematol.2022.282265

Jan 5, 2023

Editorials

Letters to the Editor

Long-term treatment with pacritinib on a compassionate use basis in patients with advanced myelofibrosis (465 Online Views)

Claire Harrison, Abdulraheem Yacoub, Bart Scott, Adam Mead, Aaron T. Gerds, Jean-Jacques Kiladjian, Ruben Mesa, Miklos Egyed, Christof Scheid, Valentin Garcia Gutierrez, Jennifer O’Sullivan, Sarah Buckley, Kris Kanellopoulos, John Mascarenhas

https://doi.org/10.3324/haematol.2022.282089

Activity of decitabine combined with all-trans retinoic acid in oligoblastic AML: Results from a randomized 2x2 phase II trial (DECIDER) (263 Online Views)

Christoph Rummelt, Olga Grishina, Claudia Schmoor, Martina Crysandt, Michael Heuser, Katharina S. Götze, Richard F. Schlenk, Konstanze Döhner, Helmut R. Salih, Gerhard Heil, Carsten Müller-Tidow, Wolfram Brugger, Andrea Kündgen, Maike de Wit, Aristoteles Giagounidis, Sebastian Scholl, Andreas Neubauer, Jürgen Krauter, Gesine Bug, Haifa Kathrin Al-Ali, Ralph Wäsch, Heiko Becker, Annette M. May, Justus Duyster, Björn Hackanson, Arnold Ganser, Hartmut Döhner, Michael Lübbert

https://doi.org/10.3324/haematol.2022.282258

Efficacy, safety, and cost of mobilization strategies in multiple myeloma: A prospective observational study (314 Online Views)

Binod Dhakal, Mei-Jei Zhang, Linda J. Burns, Xiaoying Tang, Christa Meyer, Lih-Wen Mau, Ajay K. Nooka, Edward Stadtmauer, Ivana N Micallef, Joseph McGuirk, Luciano Costa, Mark B. Juckett, Nina Shah, Richard E. Champlin, Saad Z. Usmani, Sherif S. Farag, Taiga Nishihori, Vivek Roy, Andrew Bodiford, Yvonne J. Barnes, Edward J. Drea, Parameswaran Hari, Mehdi Hamadani

https://doi.org/10.3324/haematol.2022.282269

Dec 29, 2022

Articles

Effects of nandrolone decanoate on telomere length and clinical outcome in patients with telomeropathies: a prospective trial (616 Online Views)

Diego V. Clé, Luiz Fernando B. Catto, Fernanda Gutierrez-Rodrigues, Flávia S. Donaires, Andre L. Pinto, Barbara A. Santana, Luiz Guilherme Darrigo, Elvis T. Valera, Marcel Koenigkam-Santos, José Baddini-Martinez, Neal S. Young, Edson Z. Martinez, Rodrigo T. Calado

https://doi.org/10.3324/haematol.2022.281808

Letters to the Editor

Covid-19 vaccination in patients with immune-mediated thrombotic thrombocytopenic purpura: a single-referral center experience (174 Online Views)

Silvia Maria Trisolini, Saveria Capria, Andrea Artoni, Ilaria Mancini, Mario Biglietto, Giuseppe Gentile, Flora Peyvandi, Anna Maria Testi

https://doi.org/10.3324/haematol.2022.282311

Dec 22, 2022

Editorials
Article

B and T cell acute lymphoblastic leukemia evade chemotherapy at distinct sites in the bone marrow (611 Online Views)

Malwine J. Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, César Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean-Pierre Bourquin

https://doi.org/10.3324/haematol.2021.280451

Articles

Adjusted comparison of outcomes between patients from CARTITUDE-1 versus multiple myeloma patients with prior exposure to PI, IMiD and anti-CD38 antibody from the prospective, multinational LocoMMotion study of real-world clinical practice (715 Online Views)

Maria-Victoria Mateos, Katja Weisel, Thomas Martin, Jesús G. Berdeja, Andrzej Jakubowiak, A. Keith Stewart, Sundar Jagannath, Yi Lin, Joris Diels, Francesca Ghilotti, Pushpike Thilakarathne, Nolen J Perualila, Jedelyn Cabrieto, Benjamin Haefliger, Nichola Erler-Yates, Clare Hague, Carolyn C Jackson, Jordan M Schecter, Vadim Strulev, Tonia Nesheiwat, Lida Pacaud, Hermann Einsele, Philippe Moreau

https://doi.org/10.3324/haematol.2022.280482

Reduced platelet glycoprotein Ibα shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen (401 Online Views)

Paola Simeone, Rossella Liani, Romina Tripaldi, Sonia Ciotti, Antonio Recchiuti, Vittorio Abbonante, Benedetta Porro, Piero Del Boccio, Augusto di Castelnuovo, Paola Lanuti, Marina Camera, Damiana Pieragostino, Melissa Lee-Sundlov, Myriam Luongo, Raffaella Auciello, Giuseppina Bologna, Maria Concetta Cufaro, Elena Tremoli, Karin M Hoffmeister, Francesco Cipollone, Alessandra Balduini, Francesca Santilli

https://doi.org/10.3324/haematol.2022.281006

Targeting TPO-independent strategy in the discovery of a novel megakaryocytopoiesis inducer DMAG for treatment of thrombocytopenia (345 Online Views)

Long Wang, Sha Liu, Jiesi Luo, Qi Mo, Mei Ran, Ting Zhang, Xiaoxuan Li, Wenjun Zou, Qibing Mei, Jianping Chen, Jing Yang, Jing Zeng, Feihong Huang, Anguo Wu, Chunxiang Zhang, Jianming Wu

https://doi.org/10.3324/haematol.2022.282209

Letters to the Editor

Kaposi sarcoma herpesvirus viral load as a biomarker for leptomeningeal involvement by primary effusion lymphoma (220 Online Views)

Kathryn Lurain, Ramya Ramaswami, Vickie Marshall, Elena M. Cornejo Castro, Nazzarena Labo, Wendell Miley, Kyle Moore, Romin Roshan, Ralph Mangusan, Elaine S. Jaffe, Stefania Pittaluga, Hao-Wei Wang, Mark Roth, Armando C. Filie, Thomas S. Uldrick, Denise Whitby, Robert Yarchoan

https://doi.org/10.3324/haematol.2022.281472

Sex differences in progression of kidney disease in sickle cell disease (201 Online Views)

Kenneth I. Ataga, Qingning Zhou, Santosh L. Saraf, Jane S. Hankins, Emily J. Ciccone, Laura R. Loehr, Melanie E. Garrett, Allison E. Ashley-Koch, Jianwen Cai, Marilyn J. Telen, Vimal K. Derebail

https://doi.org/10.3324/haematol.2022.281677

Allogeneic hematopoietic cell transplant for hairy cell leukemia: EBMT experience (233 Online Views)

Dai Chihara, Luuk Gras, Nienke Zinger, Nicolaus Kröger, Jiri Mayer, Jakob Passweg, Régis Peffault de Latour, Jenny Byrne, William Krüger, Jan-Paul Bohn, Uwe Platzbecker, Igor Wolfgang Blau, Francesca Bonifazi, Grzegorz Helbig, Andrew McDonald, Martin Mistrik, Mohamad Mohty, Ron Ram, Jaime Sanz, Carlos Vallejo Llamas, Robert J. Kreitman, Patrick J. Hayden, Donal McLornan, Olivier Tournilhac, Michel van Gelder, Ibrahim Yakoub-Agha

https://doi.org/10.3324/haematol.2022.281754

End-of-treatment PET in early-stage Hodgkin lymphoma: valuable in addition to interim-PET (180 Online Views)

Karan L. Chohan, Jason R. Young, Scott Lester, Muhamad Alhaj Moustafa, Allison Rosenthal, Han W. Tun, Bradford S. Hoppe, Patrick B. Johnston, Ivana N. Micallef, Thomas M. Habermann, Stephen M. Ansell

https://doi.org/10.3324/haematol.2022.282115

Retrospective analysis of a cohort of 41 de novo B-cell prolymphocytic leukemia patients: impact of genetics and targeted therapies (a FILO study) (242 Online Views)

Caroline Algrin, Louis Pérol, Elise Chapiro, Lucile Baseggio, Karim Maloum, Catherine Settegrana, Jean-François Lesesve, Justine Siavellis, Alain Delmer, Anne-Sophie Michallet, Emmanuelle Ferrant, Pierre Feugier, Cécile Tomowiak, Annie Brion, David Ghez, Luc-Matthieu Fornecker, Sarah Ivanoff, Stéphanie Struski, Laurent Sutton, Isabelle Radford-Weiss, Virginie Eclache, Christine Lefebvre, Véronique Leblond, Florence Nguyen-Khac, Damien Roos-Weil

https://doi.org/10.3324/haematol.2022.282162

Light chain amyloidosis associated with Waldenström macroglobulinemia: treatment and survival outcomes (303 Online Views)

Joshua N. Gustine, Raphael E. Szalat, Andrew Staron, Tracy Joshi, Lisa Mendelson, J. Mark Sloan, Vaishali Sanchorawala

https://doi.org/10.3324/haematol.2022.282264

Clinical and molecular features of familial chronic lymphocytic leukemia: a pilot monocentric study (168 Online Views)

Giulia Benintende, Idanna Innocenti, Alberto Fresa, Francesco Autore, Annamaria Tomasso, Alfonso Piciocchi, Florenzia Vuono, Luca Stirparo, Antonio Mosca, Andrea Bacigalupo, Valter Gattei, Dimitar Efremov, Eugenio Sangiorgi, Luca Laurenti

https://doi.org/10.3324/haematol.2022.282268

Patient-reported fatigue and pain in Erdheim-Chester disease: a registry-based, mixed methods study (207 Online Views)

Anne S. Reiner, Dana Bossert, Justin J. Buthorn, Allison M. Sigler, Selin Gonen, Deanna Fournier, Kathleen Brewer, Jessica Corkran, Gaurav Goyal, Carl E. Allen, Kenneth L. McClain, Thomas M. Atkinson, Kathleen A. Lynch, Jun J. Mao, Katherine S. Panageas, Eli L. Diamond

https://doi.org/10.3324/haematol.2022.282287

IELSG40/CLEO phase II trial of clarithromycin and lenalidomide in relapsed/refractory extranodal marginal zone lymphoma (230 Online Views)

Maria Cristina Pirosa, Marianna Sassone, Barbara Kiesewetter, Armando Lopez Guillermo, Liliana Devizzi, Eva Domingo Domènech, Alessandra Tucci, Donato Mannina, Michele Merli, Antonio Salar, Carlo Visco, Fabiana Esposito, Luisella Bonomini, Emanuele Zucca, Andrés J. M. Ferreri, Markus Raderer

https://doi.org/10.3324/haematol.2022.281963

Case Reports

Dec 15, 2022

Review Articles

Articles

Exome sequencing in 116 patients with inherited thrombocytopenia that remained of unknown origin after systematic phenotype-driven diagnostic workup (311 Online Views)

Caterina Marconi, Alessandro Pecci, Flavia Palombo, Federica Melazzini, Roberta Bottega, Elena Nardi, Valeria Bozzi, Michela Faleschini, Serena Barozzi, Tania Giangregorio, Pamela Magini, Carlo L. Balduini, Anna Savoia, Marco Seri, Patrizia Noris, Tommaso Pippucci

https://doi.org/10.3324/haematol.2022.280993

Overexpression of the key metabolic protein CPT1A defines mantle cell lymphoma patients with poor response to standard high dose chemotherapy independent of MIPI and complement established high-risk factors (263 Online Views)

Anna Sandström Gerdtsson, Joana de Matos Rodrigues, Christian Winther Eskelund, Simon Husby, Kirsten Grønbæk, Riikka Räty, Arne Kolstad, Christian Geisler, Anna Porwit, Mats Jerkeman, Sara Ek

https://doi.org/10.3324/haematol.2022.281420

CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine (478 Online Views)

Theodoros Karantanos, Patric Teodorescu, Marios Arvanitis, Brandy Perkins, Tania Jain, Amy E. DeZern, W. Brian Dalton, Ilias Christodoulou, Bogdan C. Paun, Ravi Varadhan, Christopher Esteb, Trivikram Rajkhowa, Challice Bonifant, Lukasz P. Gondek, Mark J. Levis, Srinivasan Yegnasubramanian, Gabriel Ghiaur, Richard J. Jones

https://doi.org/10.3324/haematol.2022.281444

Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia (1237 Online Views)

Heikki Kuusanmäki, Sari Kytölä, Ida Vänttinen, Tanja Ruokoranta, Amanda Ranta, Jani Huuhtanen, Minna Suvela, Alun Parsons, Annasofia Holopainen, Anu Partanen, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Imre Västrik, Olli Dufva, Sanna Siitonen, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Mika Kontro

https://doi.org/10.3324/haematol.2022.281692

Letters to the Editor

Pirtobrutinib results in reversible platelet dysfunction compared to ibrutinib and acalabrutinib (490 Online Views)

Alexander P Bye, Neline Kriek, Tanya Sage, Suzannah J Rawlings, Catherine Prodger, Murali Kesavan, Charlotte Lees, Stephen Booth, Louise G Cowen, Kirsty Shefferd, Michael J Desborough, Jonathan M Gibbins, Toby A Eyre

https://doi.org/10.3324/haematol.2022.281402

Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19 (216 Online Views)

Matthias H. Busch, Sjoerd A.M.E.G. Timmermans, Sander M.J. van Kuijk, Joop P. Aendekerk, Renée Ysermans, Daan P.C. van Doorn, Judith Potjewijd, Marcel C.G. van de Poll, Iwan C.C. van der Horst, Jan G.M.C. Damoiseaux, Henri M.H. Spronk, Hugo ten Cate, Chris P. Reutelingsperger, Magdolna Nagy, Pieter van Paassen

https://doi.org/10.3324/haematol.2022.281693

Combination therapy with crizotinib and vinblastine for relapsed or refractory pediatric ALK-positive anaplastic large cell lymphoma (278 Online Views)

Fabian Knörr, Kim P.J. Schellekens, Reineke A. Schoot, Judith Landman-Parker, Heiko-Manuel Teltschik, Jan Förster, Amambay Riquelme, Alwin D.R. Huitema, Natasha K.A. van Eijkelenburg, Auke Beishuizen, C. Michel Zwaan, Wilhelm Woessmann, Jasper van der Lugt

https://doi.org/10.3324/haematol.2022.281896

Predictors of response to venetoclax plus hypomethylating agent therapy and survival in blast-phase myeloproliferative neoplasm (380 Online Views)

Naseema Gangat, Rimal Ilyas, Kristen McCullough, Kebede H. Begna, Aref Al-Kali, Mrinal M. Patnaik, Mark R. Litzow, William J. Hogan, Abhishek Mangaonkar, Hassan Alkhateeb, Mithun V. Shah, Michelle A. Elliott, James M. Foran, Talha Badar, Jeanne M. Palmer, Curtis A. Hanson, Animesh Pardanani, Ayalew Tefferi

https://doi.org/10.3324/haematol.2022.282019

Dec 7, 2022

Editorials
Article

Allogeneic, Off-the-Shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high risk patients (626 Online Views)

Spyridoula Vasileiou, LaQuisa Hill, Manik Kuvalekar, Aster G. Workineh, Ayumi Watanabe, Yovana Velazquez, Suhasini Lulla, Kimberly Mooney, Natalia Lapteva, Bambi J. Grilley, Helen E. Heslop, Cliona M. Rooney, Malcolm K. Brenner, Todd N. Eagar, George Carrum, Kevin A. Grimes, Ann M. Leen, Premal Lulla

https://doi.org/10.3324/haematol.2022.281946

Articles

Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsuficiency (506 Online Views)

Avigail Rein, Ifat Geron, Eitan Kugler, Hila Fishman, Eyal Gottlieb, Ifat Abramovich, Amir Giladi, Ido Amit, Roger Mulet-Lazaro, Ruud Delwel, Stefan Gröschel, Smadar Levin-Zaidman, Nili Dezorella, Vered Holdengreber, Tata Nageswara Rao, Joanne Yacobovich, Orna Steinberg-Shemer, Qiu-Hua Huang, Yun Tan, Sai-Juan Chen, Shai Izraeli, Yehudit Birger

https://doi.org/10.3324/haematol.2022.279437

Adipocytes control haematopoiesis and inflammation through CD40 signaling (468 Online Views)

Myrthe E. Reiche, Kikkie Poels, Laura A. Bosmans, Winnie G. Vos, Claudia M. van Tiel, Marion J.J. Gijbels, Suzanne A.B.M. Aarts, Myrthe den Toom, Linda Beckers, Christian Weber, Dorothee Atzler, Patrick C.N. Rensen, Sander Kooijman, Esther Lutgens

https://doi.org/10.3324/haematol.2022.281482

Letters to the Editor

Time without transfusion reliance: a novel patient-centric metric for new therapies in myelodysplastic syndromes (453 Online Views)

Joshua F. Zeidner, Flora Mazerolle, Jonathan Norton, Antoine Regnault, Fjoralba Kristo, Heather Romero, Robert J. Fram, Douglas V. Faller, Mehul Dalal, Lionel Ades, Mikkael A. Sekeres

https://doi.org/10.3324/haematol.2022.281856

Pirtobrutinib and venetoclax combination overcomes resistance to targeted and CAR Tcell therapy in aggressive mantle cell lymphoma (534 Online Views)

Yang Liu, Fangfang Yan, Vivian Changying Jiang, Yijing Li, Yuxuan Che, Joseph McIntosh, Alexa Jordan, Ian Hou, Lei Nie, Jingling Jin, Wei Wang, Heng-Huan Lee, Yixin Yao, Michael Wang

https://doi.org/10.3324/haematol.2022.282031

Case Reports

Sirolimus as frontline therapy for PTEN-mutated histiocytic sarcoma (286 Online Views)

Karan L. Chohan, Jithma P. Abeykoon, Jason R. Young, W. Oliver Tobin, Mathew J. Koster, Mithun V. Shah, Jay H. Ryu, Robert Vassallo, Karen L. Rech., Aishwarya Ravindran, Gaurav Goyal, Ronald S. Go, N. Nora Bennani

https://doi.org/10.3324/haematol.2022.282207

Dec 1, 2022

Editorials
Article

ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study (428 Online Views)

David Sibon, Bettina Bisig, Christophe Bonnet, Elsa Poullot, Emmanuel Bachy, Doriane Cavalieri, Virginie Fataccioli, Cloe Bregnard, Fanny Drieux, Julie Bruneau, Francois Lemonnier, Aurelie Dupuy, Celine Bossard, Marie Parrens, Krimo Bouabdallah, Nicolas Ketterer, Gregoire Berthod, Anne Cairoli, Gandhi Damaj, Olivier Tournilhac, Jean-Philippe Jais, Philippe Gaulard, Laurence de Leval

https://doi.org/10.3324/haematol.2022.281442
Article

DUSP22 rearrangement is associated with distinctive immunophenotype but not outcome in patients with systemic ALK-negative anaplastic large cell lymphoma (336 Online Views)

Lianqun Qiu, Guilin Tang, Shaoying Li, Francisco Vega, Pei Lin, Sa A. Wang, Wei Wang, Swaminathan P. Iyer, Luis Malpica, Roberto N. Miranda, Sergej Konoplev, Zhenya Tang, Hong Fang, L. Jeffrey Medeiros, Jie Xu

https://doi.org/10.3324/haematol.2022.281222

Editorials
Article

Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on Cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation (747 Online Views)

Elena Tassi, Maddalena Noviello, Pantaleo De Simone, Maria T. Lupo-Stanghellini, Matteo Doglio, Francesca Serio, Danilo Abbati, Valeria Beretta, Veronica Valtolina, Giacomo Oliveira, Sara Racca, Edoardo Campodonico, Eliana Ruggiero, Daniela Clerici, Fabio Giglio, Francesca Lorentino, Roee Dvir, Elisabetta Xue, Francesca Farina, Chiara Oltolini, Francesco Manfredi, Luca Vago, Consuelo Corti, Massimo Bernardi, Massimo Clementi, Liselotte Brix, Fabio Ciceri, Jacopo Peccatori, Raffaella Greco, Chiara Bonini

https://doi.org/10.3324/haematol.2022.280685

Editorials

Editorials
Article

Targeting glutaminase is therapeutically effective in ibrutinib-resistant mantle cell lymphoma (412 Online Views)

Lingzhi Li, Lei Nie, Alexa Jordan, Qingsong Cai, Yang Liu, Yijing Li, Yuxuan Che, Jovanny Vargas, Zhihong Chen, Angela Leeming, Wei Wang, Yixin Yao, Michael Wang, Vivian Changying Jiang

https://doi.org/10.3324/haematol.2022.281538

Articles

Immune thrombotic thrombocytopenic purpura plasmas induce calcium- and IgG-dependent endothelial activation: correlations with disease severity (272 Online Views)

Edwige Tellier, Agnès Widemann, Raphaël Cauchois, Julien Faccini, Marie Lagarde, Marion Brun, Philippe Robert, Stéphane Robert, Richard Bachelier, Pascale Poullin, Elien Roose, Karen Vanhoorelbeke, Paul Coppo, Françoise Dignat-George, Gilles Kaplanski

https://doi.org/10.3324/haematol.2022.280651

Letters to the Editor

Targeting cytokine-induced leukemic stem cell persistence in chronic myeloid leukemia by IKK2-inhibition (302 Online Views)

Marlena Bütow, Fabio J. Testaquadra, Julian Baumeister, Tiago Maié, Nicolas Chatain, Timo Jaquet, Stefan Tillmann, Martina Crysandt, Ivan G. Costa, Tim H. Brümmendorf, Mirle Schemionek

https://doi.org/10.3324/haematol.2022.280922

Nov 24, 2022

Articles

Hyperactive CREB subpopulations increase during therapy in paediatric B lineage acute lymphoblastic leukaemia (288 Online Views)

Dino Masic, Kayleigh Fee, Hayden Bell, Marian Case, Gabby Witherington, Sophie Lansbury, Juan Ojeda-Garcia, David McDonald, Claire Schwab, Frederik W. van Delft, Andrew Filby, Julie Anne Elizabeth Irving

https://doi.org/10.3324/haematol.2022.281177

Targeting glutaminase is therapeutically effective in ibrutinib-resistant mantle cell lymphoma (412 Online Views)

Lingzhi Li, Lei Nie, Alexa Jordan, Qingsong Cai, Yang Liu, Yijing Li, Yuxuan Che, Jovanny Vargas, Zhihong Chen, Angela Leeming, Wei Wang, Yixin Yao, Michael Wang, Vivian Changying Jiang

https://doi.org/10.3324/haematol.2022.281538

Letters to the Editor

Landscape of immunoglobulin heavy chain gamma gene class switch recombination in patients with adult T-cell leukemia–lymphoma (272 Online Views)

Hiroaki Hiramatsu, Kisato Nosaka, Shigeru Kusumoto, Nobuaki Nakano, Ilseung Choi, Makoto Yoshimitsu, Yoshitaka Imaizumi, Michihiro Hidaka, Hidenori Sasaki, Junya Makiyama, Eiichi Ohtsuka, Tatsuro Jo, Masao Ogata, Asahi Ito, Kentaro Yonekura, Hiro Tatetsu, Takeharu Kato, Toshiro Kawakita, Youko Suehiro, Kenji Ishitsuka, Shinsuke Iida, Takaji Matsutani, Hiroyoshi Nishikawa, Atae Utsunomiya, Ryuzo Ueda, Takashi Ishida

https://doi.org/10.3324/haematol.2022.281435

Nov 17, 2022

Editorials
Article

Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through inhibition of autophagy (787 Online Views)

Weiguo Zhang, Guopan Yu, Hongying Zhang, Mahesh Basyal, Charlie Ly, Bin Yuan, Vivian Ruvolo, Sujan Piya, Seemana Bhattacharya, Qi Zhang, Gautam Borthakur, Venkata Battula, Marina Konopleva, William G. Rice, Michael Andreeff

https://doi.org/10.3324/haematol.2022.280884

Editorials
Letter to the Editor

Age- and gender-matched controls needed for platelet-based biomarker studies (254 Online Views)

Siamack Sabrkhany, Marijke J.E. Kuijpers, Sander M.J. van Kuijk, Arjan W. Griffioen, Mirjam G.A. oude Egbrink

https://doi.org/10.3324/haematol.2022.281726

Review Articles

Animal models of Diamond-Blackfan anemia: updates and challenges (1468 Online Views)

Y. Lucy Liu, Aya Shibuya, Bert Glader, Mark C. Wilkes, Maria Barna, Kathleen M. Sakamoto

https://doi.org/10.3324/haematol.2022.282042

Articles

Diffuse large B-cell lymphoma in octogenarians aged 85 and older can benefit from treatment with curative intent: a report on 129 patients prospectively registered in the Elderly Project of the Fondazione Italiana Linfomi (FIL) (1581 Online Views)

Alessandra Tucci, Francesco Merli, Alberto Fabbri, Luigi Marcheselli, Chiara Pagani, Benedetta Puccini, Dario Marino, Manuela Zanni, Elsa Pennese, Leonardo Flenghi, Annalisa Arcari, Barbara Botto, Melania Celli, Caterina Mammi, Alessandro Re, Giulia Campostrini, Agostino Tafuri, Vittorio R. Zilioli, Emanuele Cencini, Roberto Sartori, Chiara Bottelli, Michele Merli, Luigi Petrucci, Guido Gini, Monica Balzarotti, Federica Cavallo, Gerardo Musuraca, Stefano Luminari, Giuseppe Rossi, Michele Spina

https://doi.org/10.3324/haematol.2022.281407

Letters to the Editor

Axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma patients in complete metabolic response (381 Online Views)

Andrew P. Jallouk, Sushanth Gouni, Jason Westin, Lei Feng, Haleigh Mistry, Raphael E. Steiner, Jinsu James, Mansoor Noorani, Sandra Horowitz, Nahum Puebla-Osorio, Luis E. Fayad, Swaminathan P. Iyer, Misha Hawkins, Christopher R. Flowers, Sairah Ahmed, Loretta J. Nastoupil, Partow Kebriaei, Elizabeth J. Shpall, Sattva S. Neelapu, Yago Nieto, Paolo Strati

https://doi.org/10.3324/haematol.2022.281954

Case Reports

Clinical response to dabrafenib and chemotherapy in clonally-related histiocytosis and acute lymphoblastic leukemia (1466 Online Views)

Gervaise Hubert, Henrique Bittencourt, Caroline Laverdière, Pierre Teira, Sonia Cellot, Sylvie Langlois, Alexandre Rouette, Thomas Sontag, Daniel Sinnett, Dorothée Dal-Soglio, Sophie Turpin, Thai Hoa Tran

https://doi.org/10.3324/haematol.2022.281926

Nov 10, 2022

Articles

Allogeneic, Off-the-Shelf, SARS-CoV-2-specific T cells (ALVR109) for the treatment of COVID-19 in high risk patients (626 Online Views)

Spyridoula Vasileiou, LaQuisa Hill, Manik Kuvalekar, Aster G. Workineh, Ayumi Watanabe, Yovana Velazquez, Suhasini Lulla, Kimberly Mooney, Natalia Lapteva, Bambi J. Grilley, Helen E. Heslop, Cliona M. Rooney, Malcolm K. Brenner, Todd N. Eagar, George Carrum, Kevin A. Grimes, Ann M. Leen, Premal Lulla

https://doi.org/10.3324/haematol.2022.281946

Contribution of fetal microchimeric cells to maternal wound healing in sickle cell ulcers (286 Online Views)

Mansour Alkobtawi, Maria Sbeih, Karim Souaid, Qui Trung Ngô, Dany Nassar, Hugo Arbes, Henri Guillet, Anoosha Habibi, Pablo Bartolucci, Mathieu Castela, Sélim Aractingi, Bénédicte Oulès

https://doi.org/10.3324/haematol.2022.281140

Letters to the Editor

Longitudinal analysis of the evolution of cellular immunity to SARS-CoV-2 induced by infection and vaccination (1414 Online Views)

Spyridoula Vasileiou, Manik Kuvalekar, Yovana Velazquez, Ayumi Watanabe, Mansi Narula, Aster G. Workineh, Matthew French-Kim, Alejandro Torres Chavez, Sarah Gilmore, Cliona M. Rooney, Ann M. Leen

https://doi.org/10.3324/haematol.2022.281947

Perspective Articles

Nov 3, 2022

Articles

B and T cell acute lymphoblastic leukemia evade chemotherapy at distinct sites in the bone marrow (611 Online Views)

Malwine J. Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, César Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean-Pierre Bourquin

https://doi.org/10.3324/haematol.2021.280451

Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia patients enrolled in measurable residual disease-oriented trials (667 Online Views)

Celia González-Gil, Mireia Morgades, Thaysa Lopes, Francisco Fuster-Tormo, Jesús García-Chica, Ran Zhao, Pau Montesinos, Anna Torrent, Marina Diaz-Beya, Rosa Coll, Lourdes Hermosín, Santiago Mercadal, José González-Campos, Lurdes Zamora, Teresa Artola, Ferran Vall-Llovera, Mar Tormo, Cristina Gil-Cortés, Pere Barba, Andrés Novo, Jordi Ribera, Teresa Bernal, Paula López de Ugarriza, María-Paz Queipo, Pilar Martínez-Sánchez, Alicia Giménez, Teresa González-Martínez, Antonia Cladera, José Cervera, Rosa Fernández-Martín, María Ángeles Ardaiz, María Jesús Vidal, Ángela Baena, Nuria López-Bigas, Anna Bigas, Jaroslaw Maciejewski, Alberto Orfao, Josep Maria Ribera, Eulalia Genescà

https://doi.org/10.3324/haematol.2022.281196

An objective assessment in newly diagnosed multiple myeloma to avoid treatment complications and strengthen therapy adherence (269 Online Views)

Maximilian Holler, Gabriele Ihorst, Heike Reinhardt, Amelie Rösner, Magdalena Braun, Mandy-Deborah Möller, Esther Dreyling, Katja Schoeller, Sophia Scheubeck, Ralph Wäsch, Monika Engelhardt

https://doi.org/10.3324/haematol.2022.281489

Oct 27, 2022

Editorials
Article

Improved survival in myeloma patients– a nationwide registry study of 4647 patients ≥75 years treated in Denmark and Sweden (446 Online Views)

Kari Lenita Falck Moore, Ingemar Turesson, Anna Genell, Tobias W. Klausen, Dorota Knut-Bojanowska, Louise Redder, Ingigerdur Sverrisdottir, Jonathan Thorsen, Annette J. Vangsted, Cecilie H. Blimark

https://doi.org/10.3324/haematol.2021.280424

Oct 20, 2022

Editorials
Article

Pathology review identifies frequent misdiagnoses in recurrent classic Hodgkin lymphoma in a nation-wide cohort: Implications for clinical and epidemiological studies (389 Online Views)

Max V. Boot, Michael Schaapveld, Esther C. van den Broek, Nathalie J. Hijmering, PALGA Group, Kimberly van der Oord, Flora E. van Leeuwen, Avinash G. Dinmohamed, Lianne Koens, Daphne de Jong

https://doi.org/10.3324/haematol.2022.280840

Review Articles

Oct 13, 2022

Editorials
Letter to the Editor

Clonal hematopoiesis by DNMT3A mutations as a common finding in idiopathic splanchnic vein thrombosis (379 Online Views)

Giovanna Carrà, Emilia Giugliano, Sofia Camerlo, Giorgio Rosati, Enrica Branca, Beatrice Maffeo, Isabella Russo, Rocco Piazza, Daniela Cilloni, Alessandro Morotti

https://doi.org/10.3324/haematol.2022.281705

Editorials

Articles

Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through inhibition of autophagy (787 Online Views)

Weiguo Zhang, Guopan Yu, Hongying Zhang, Mahesh Basyal, Charlie Ly, Bin Yuan, Vivian Ruvolo, Sujan Piya, Seemana Bhattacharya, Qi Zhang, Gautam Borthakur, Venkata Battula, Marina Konopleva, William G. Rice, Michael Andreeff

https://doi.org/10.3324/haematol.2022.280884

Case Reports

Leon's helmet (239 Online Views)

Hugo Gonzalez, Alice Marceau-Renaut, Marc Spentchian, Maen Hassoun, Geoffroy Guignedoux

https://doi.org/10.3324/haematol.2022.281125

Oct 6, 2022

Articles

Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on Cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation (747 Online Views)

Elena Tassi, Maddalena Noviello, Pantaleo De Simone, Maria T. Lupo-Stanghellini, Matteo Doglio, Francesca Serio, Danilo Abbati, Valeria Beretta, Veronica Valtolina, Giacomo Oliveira, Sara Racca, Edoardo Campodonico, Eliana Ruggiero, Daniela Clerici, Fabio Giglio, Francesca Lorentino, Roee Dvir, Elisabetta Xue, Francesca Farina, Chiara Oltolini, Francesco Manfredi, Luca Vago, Consuelo Corti, Massimo Bernardi, Massimo Clementi, Liselotte Brix, Fabio Ciceri, Jacopo Peccatori, Raffaella Greco, Chiara Bonini

https://doi.org/10.3324/haematol.2022.280685

Development and manufacturing of novel locally produced anti-BCMA CAR-T cells for the treatment of relapsed/refractory multiple myeloma: phase I clinical results (2086 Online Views)

Nathalie Asherie, Shlomit Kfir-Erenfeld, Batia Avni, Miri Assayag, Tatyana Dubnikov, Nomi Zalcman, Eyal Lebel, Eran Zimran, Adir Shaulov, Marjorie Pick, Yael Cohen, Irit Avivi, Cyrille Cohen, Moshe E. Gatt, Sigal Grisariu, Polina Stepensky

https://doi.org/10.3324/haematol.2022.281628

Letters to the Editor

Age- and gender-matched controls needed for platelet-based biomarker studies (254 Online Views)

Siamack Sabrkhany, Marijke J.E. Kuijpers, Sander M.J. van Kuijk, Arjan W. Griffioen, Mirjam G.A. oude Egbrink

https://doi.org/10.3324/haematol.2022.281726

Sep 29, 2022

Editorials
Article

Heterogeneity in long term outcomes for R-ISS stage II in newly diagnosed multiple myeloma patients (487 Online Views)

Anais Schavgoulidze, Valerie Lauwers-Cances, Aurore Perrot, Titouan Cazaubiel, Marie-Lorraine Chretien, Philippe Moreau, Thierry Facon, Xavier Leleu, Lionel Karlin, Anne-Marie Stoppa, Olivier Decaux, Karim Belhadj, Bertrand Arnulf, Mohamad Mohty, Clara M ariette, Cecile Fohrer-Sonntag, Pascal Lenain, Jean-Pierre Marolleau, Mourad Tiab, Carla Araujo, Frederique Orsini-Piocelle, Arnaud Jaccard, Murielle Roussel, Lotfi Benboubker, Jean-Richard Eveillard, Mamoun Dib, Marion Divoux, Michel Attal, Herve Avet-Loiseau, Jill Corre

https://doi.org/10.3324/haematol.2021.280566

Articles

Plasminogen activator-coated nanobubbles targeting cell-bound β2-glycoprotein I as a novel thrombus-specific thrombolytic strategy (415 Online Views)

Paolo Macor, Paolo Durigutto, Monica Argenziano, Kate Smith-Jackson, Sara Capolla, Valeria Di Leonardo, Kevin Marchbank, Valerio Stefano Tolva, Fabrizio Semeraro, Concetta T. Ammollo, Mario Colucci, Roberta Cavalli, Pierluigi Meroni, Francesco Tedesco

https://doi.org/10.3324/haematol.2022.281505

Aug 25, 2022

Editorials
Article

ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA axis mediated neoplastic fibrocyte generation in myeloproliferative neoplasms (758 Online Views)

Zhongxun Shi, Jinqin Liu, Yingying Zhao, Lin Yang, Yanan Cai, Peihong Zhang, Zefeng Xu, Tiejun Qin, Shiqiang Qu, Lijuan Pan, Junying Wu, Xin Yan, Zexing Li, Wenjun Zhang, Yiru Yan, Huijun Huang, Gang Huang, Bing Li, Xudong Wu, Zhijian Xiao

https://doi.org/10.3324/haematol.2021.280320

Editorials
Article

Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications (904 Online Views)

Christer Nilsson, Fredrika Linde, Erik Hulegårdh, Hege Garelius, Vladimir Lazarevic, Petar Antunovic, Jörg Cammenga, Stefan Deneberg, Anna Eriksson, Martin Jädersten, Cecilia Kämpe Björkvall, Lars Möllgård, Lovisa Wennström, Emma Ölander, Martin Höglund, Gunnar Juliusson, Sören Lehmann

https://doi.org/10.3324/haematol.2022.281233

Editorials
Article

Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia (953 Online Views)

Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Chien-Chin Lin, Wei-Ju Liao, Fu-An Li, Ling-Hui Li, Kurt Yun Mou, Steve R. Roffler, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang

https://doi.org/10.3324/haematol.2022.281151

Aug 4, 2022

Editorials
Letter to the Editor

Morbidity and mortality of sickle cell disease patients is unaffected by splenectomy: evidence from 3 decades follow-up in a high-income setting (363 Online Views)

Valeria Maria Pinto, Barbara Gianesin, Frédéric B. Piel, Filomena Longo, Paolo Rigano, Alessandra Quota, Vincenzo Spadola, Giovanna Graziadei, Filippo Mazzi, Maria Domenica Cappellini, Aurelio Maggio, Antonio Piga, Lucia De Franceschi, Gian Luca Forni

https://doi.org/10.3324/haematol.2022.280815

Jul 28, 2022

Editorials
Article

Improving the anti-acute myeloid leukemia activity of CD123-specific Engager T cells by MyD88 and CD40 costimulation (1571 Online Views)

Abishek Vaidya, Erin Doherty, Xiya Wu, Sujuan Huang, Nikhil Hebbar, Unmesha Thanekar, Challice L. Bonifant, Cheng Cheng, Stephen Gottschalk, M. Paulina Velasquez

https://doi.org/10.3324/haematol.2021.279301

Jul 21, 2022

Editorials
Article

Hypercortisolemic Cushing's patients possess a distinct class of hematopoietic progenitor cells leading to erythrocytosis (693 Online Views)

Lilian Varricchio, Eliza B Geer, Fabrizio Martelli, Maria Mazzarini, Alister Funnell, James J Bieker, Thalia Papayannopoulou, Anna Rita Migliaccio

https://doi.org/10.3324/haematol.2021.280542

Editorials
Article

Time spent at home among older adults with acute myeloid leukemia receiving azacitidine- or venetoclax-based regimens (772 Online Views)

Christopher E. Jensen, Hilary M. Heiling, Konan E. Beke, Allison M. Deal, Ashley L. Bryant, Lorinda A. Coombs, Matthew C. Foster, Daniel R. Richardson

https://doi.org/10.3324/haematol.2022.280728

Jul 14, 2022

Editorials

Jun 30, 2022

Editorials
Article

Comparison of autologous and allogeneic hematopoietic cell transplantation strategies in patients with primary plasma cell leukemia, with dynamic prediction modelling (1024 Online Views)

Sarah Lawless, Simona Iacobelli, Nina Simone Knelange, Patrice Chevallier, Didier Blaise, Noel Milpied, Roberto Foà, Jan J. Cornelissen, Bruno Lioure, Ruben Benjamin, Xavier Poiré, Monique C. Minnema, Matthew Collin, Stig Lenhoff, John A. Snowden, Stella Santarone, Keith M. O. Wilson, Fernanda Trigo, Peter Dreger, Lara H. Böhmer, Hein Putter, Laurent Garderet, Nicolaus Kröger, Ibrahim Yaukoub-Agha, Stefan Schönland, Curly Morris

https://doi.org/10.3324/haematol.2021.280568

Editorials

Articles

Comparison of autologous and allogeneic hematopoietic cell transplantation strategies in patients with primary plasma cell leukemia, with dynamic prediction modelling (1024 Online Views)

Sarah Lawless, Simona Iacobelli, Nina Simone Knelange, Patrice Chevallier, Didier Blaise, Noel Milpied, Roberto Foà, Jan J. Cornelissen, Bruno Lioure, Ruben Benjamin, Xavier Poiré, Monique C. Minnema, Matthew Collin, Stig Lenhoff, John A. Snowden, Stella Santarone, Keith M. O. Wilson, Fernanda Trigo, Peter Dreger, Lara H. Böhmer, Hein Putter, Laurent Garderet, Nicolaus Kröger, Ibrahim Yaukoub-Agha, Stefan Schönland, Curly Morris

https://doi.org/10.3324/haematol.2021.280568

Jan 13, 2022

Articles

Oncogenic TYK2P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade (1295 Online Views)

Katharina Woess, Sabine Macho-Maschler, Dorette S. van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, Claus Vogl, Anna Koren, Stefan Kubicek, Anna Orlova, Richard Moriggl, Birgit Strobl, Veronika Sexl, Frank N. van Leeuwen, Roland P. Kuiper, Mathias Mueller

https://doi.org/10.3324/haematol.2021.279848

Aug 19, 2021

Errata Corrige

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (2712 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2021.279802

May 10, 2018

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells (1086 Online Views)

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

https://doi.org/10.3324/haematol.2018.189399