Early view

Sep 22, 2022

Articles

Genome-wide CRISPR screens identify ferroptosis as a novel therapeutic vulnerability in acute lymphoblastic leukemia (89 Online Views)

Marie-Eve Lalonde, Marc Sasseville, Anne-Marie Gélinas, Jean-Sébastien Milanese, Kathie Béland, Simon Drouin, Elie Haddad, Richard Marcotte

https://doi.org/10.3324/haematol.2022.280786

Small molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy (77 Online Views)

Uta M. Demel, Matthias Wirth, Schayan Yousefian, Le Zhang, Konstandina Isaakidis, Judith Dönig, Marlitt Böger, Nikita Singh, Hazal Köse, Simon Haas, Stefan Müller, Markus Schick, Ulrich Keller

https://doi.org/10.3324/haematol.2022.280995

Letters to the Editor

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B cell impairment and increases the risk for infections - a retrospective matched cohort study (52 Online Views)

Michael Launspach, Dennis Temel, Emily Ohlendorf, Felix Zirngibl, Bianca Materne, Lena Oevermann, Hedwig E. Deubzer, Anton G. Henssen, Annette Künkele, Patrick Hundsdörfer, Horst von Bernuth, Axel Pruß, Angelika Eggert, Arend von Stackelberg, Peter Lang, Johannes H. Schulte

https://doi.org/10.3324/haematol.2022.281134

Von Willebrand factor in the plasma and in the tumor tissue predicts cancerassociated thrombosis and mortality (35 Online Views)

Ioannis Karampinis, Kai Nowak, Julian Koett, Christian Mess, Laura Wagner, Timo Gaiser, Frank Thomas Mayer, Lukas Goertz, Stefan Werner Schneider, Alexander Thomas Bauer

https://doi.org/10.3324/haematol.2022.281315

Donor cell-derived myelofibrosis relapse after allogeneic stem cell transplantation (35 Online Views)

Patrizia Chiusolo, Nicoletta Orlando, Sabrina Giammarco, Monica Rossi, Elisabetta Metafuni, Salvatore Leotta, Giuseppe Milone, Caterina Giovanna Valentini, Maria Bianchi, Filippo Frioni, Claudio Pellegrino, Federica Sorà, Luigi Maria Larocca, Simona Sica, Andrea Bacigalupo, Luciana Teofili

https://doi.org/10.3324/haematol.2022.281564

Contribution of measurable residual disease status to prediction accuracy of relapse and survival in adults with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation (69 Online Views)

Eduardo Rodríguez-Arbolí, Megan Othus, Corentin Orvain, Lucas C. Zarling, Brenda M. Sandmaier, Filippo Milano, Gary Schoch, Chris Davis, H. Joachim Deeg, Frederick R. Appelbaum, Rainer Storb, Roland B. Walter

https://doi.org/10.3324/haematol.2022.281631

Sep 15, 2022

Letters to the Editor

Clinical impact of clonal hematopoiesis on severe COVID-19 patients without canonical risk factors (112 Online Views)

Chang Kyung Kang, Baekgyu Choi, Sugyeong Kim, Choong Hyun Sun, Soon Ho Yoon, Kyukwang Kim, Euijin Chang, Jongtak Jung, Pyoeng Gyun Choe, Wan Beom Park, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh, Hogune Im, Joohae Kim, Yong Hoon Lee, Jaehee Lee, Hyonho Chun, Youngil Koh, Ji Yeon Lee, Joon Ho Moon, Kyoung-Ho Song, Inkyung Jung

https://doi.org/10.3324/haematol.2022.280621

Mitigation of gastrointestinal graft versus host disease with tocilizumab prophylaxis is accompanied by preservation of microbial diversity and attenuation of enterococcal domination (91 Online Views)

Saurabh Chhabra, Aniko Szabo, Annelie Clurman, Katelynn McShane, Nicholas Waters, Daniel Eastwood, Lisa Samanas, Teng Fei, Gabriel Armijo, Sameen Abedin, Walter Longo, Parameswaran Hari, Mehdi Hamadani, Nirav N. Shah, Lyndsey Runaas, James H. Jerkins, Marcel van den Brink, Jonathan U. Peled, William R. Drobyski

https://doi.org/10.3324/haematol.2022.281309

Sep 8, 2022

Articles

Targeting dual oncogenic machineries driven by TAL1 and PI3K-AKT pathways in T-cell acute lymphoblastic leukemia (187 Online Views)

Fang Qi Lim, Allison Si-Yu Chan, Rui Yokomori, Xiao Zi Huang, Madelaine Skolastika Theardy, Allen Eng Juh Yeoh, Shi Hao Tan, Takaomi Sanda

https://doi.org/10.3324/haematol.2022.280761

Activation of lncRNA NEAT1 leads to survival advantage of multiple myeloma cells by supporting a positive regulatory loop with DNA repair proteins (186 Online Views)

Elisa Taiana, Cecilia Bandini, Vanessa Katia Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Katia Todoerti, Silvia Erratico, Domenica Giannandrea, Niccolò Bolli, Nicola Amodio, Alessia Ciarrocchi, Raffaella Chiaramonte, Yvan Torrente, Roberto Piva, Antonino Neri

https://doi.org/10.3324/haematol.2022.281167

Letters to the Editor

Treatment patterns and clinical outcomes of asciminib in a real-world multi-resistant chronic myeloid leukemia patient population (173 Online Views)

Camille C.B. Kockerols, Jeroen J.W.M Janssen, Nicole M.A. Blijlevens, Saskia K. Klein, Laura G.M. van Hussen-Daenen, Gwendolyn G.Y. van Gorkom, Willem M. Smit, Peter van Balen, Bart J. Biemond, Marjan J. Cruijsen, Maarten F. Corsten, Peter A.W. te Boekhorst, Harry R. Koene, Geerte L. van Sluis, Jan J. Cornelissen, Peter E. Westerweel

https://doi.org/10.3324/haematol.2022.281386

Adverse karyotype subcategories in acute myeloid leukemia display significant differences in mutation composition and transplant-augmented survival (124 Online Views)

Ayalew Tefferi, Amritpal Singh, Naseema Gangat, Aref Al-Kali, Hassan Alkhateeb, Mithun Shah, Mrinal S. Patnaik, Michelle A. Elliott, William J. Hogan, Mark R. Litzow, Alexandra Wolanskyj-Spinner, Christopher C. Hook, Abhishek Mangaonkar, David Viswanatha, Dong Chen, Animesh Pardanani, Kebede H. Begna, Rhett P. Ketterling

https://doi.org/10.3324/haematol.2022.281495

Sep 1, 2022

Articles

ATRA works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T-cells (206 Online Views)

Estefanía García-Guerrero, Luis G. Rodríguez-Lobato, Belén Sierro-Martínez, Sophia Danhof, Stephan Bates, Silke Frenz, Larissa Härtle, Ralph Götz, Markus Sauer, Leo Rasche, K. Martin Kortüm, Jose A. Pérez-Simón, Hermann Einsele, Michael Hudecek, Sabrina R. Prommersberger

https://doi.org/10.3324/haematol.2022.281339

Aug 25, 2022

Editorials
Article

ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA axis mediated neoplastic fibrocyte generation in myeloproliferative neoplasms (146 Online Views)

Zhongxun Shi, Jinqin Liu, Yingying Zhao, Lin Yang, Yanan Cai, Peihong Zhang, Zefeng Xu, Tiejun Qin, Shiqiang Qu, Lijuan Pan, Junying Wu, Xin Yan, Zexing Li, Wenjun Zhang, Yiru Yan, Huijun Huang, Gang Huang, Bing Li, Xudong Wu, Zhijian Xiao

https://doi.org/10.3324/haematol.2021.280320

Editorials
Article

Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications (438 Online Views)

Christer Nilsson, Fredrika Linde, Erik Hulegårdh, Hege Garelius, Vladimir Lazarevic, Petar Antunovic, Jörg Cammenga, Stefan Deneberg, Anna Eriksson, Martin Jädersten, Cecilia Kämpe Björkvall, Lars Möllgård, Lovisa Wennström, Emma Ölander, Martin Höglund, Gunnar Juliusson, Sören Lehmann

https://doi.org/10.3324/haematol.2022.281233

Editorials
Article

Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia (437 Online Views)

Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Chien-Chin Lin, Wei-Ju Liao, Fu-An Li, Ling-Hui Li, Kurt Yun Mou, Steve R. Roffler, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen-Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang

https://doi.org/10.3324/haematol.2022.281151

Articles

Serum vascular endothelial growth factor is associated with cardiovascular involvement and response to therapy in Erdheim-Chester disease (183 Online Views)

Anais Roeser, Marine Bravetti, Lida Dong, Levi-Dan Azoulay, Frederic Charlotte, Makoto Miyara, Pascale Ghillani-Dalbin, Jean-Francois Emile, Fadwa El Kouari, Hamza Ouni, Jean-Marc Lacorte, Isabelle Brocheriou, Zahir Amoura, Fleur Cohen-Aubart, Julien Haroche

https://doi.org/10.3324/haematol.2022.280755

BCL6 inhibition ameliorates ruxolitinib resistance in CRLF2-rearranged acute lymphoblastic leukemia (253 Online Views)

Shinobu Tsuzuki, Takahiko Yasuda, Hiroaki Goto, Naoko Maeda, Koshi Akahane, Takeshi Inukai, Hideyuki Yamamoto, Sivasundaram Karnan, Akinobu Ota, Toshinori Hyodo, Hiroyuki Konishi, Yoshitaka Hosokawa, Hitoshi Kiyoi, Fumihiko Hayakawa

https://doi.org/10.3324/haematol.2022.280879

Letters to the Editor

Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization (409 Online Views)

Fiona E. Reed, Nicole M. Eskow, Elizabeth Min, Maximillian Carlino, Rubia Mancuso, Nayoung Kwon, Elenoe C. Smith, Shannon T. Larsuel, Lin Wang, Vanessa Scanlon, Diane S. Krause

https://doi.org/10.3324/haematol.2021.280499

Alpha-beta T and B-cell depleted HLA-haploidentical HSCT in children with myelodysplastic syndromes (144 Online Views)

Pietro Merli, Daria Pagliara, Tommaso Mina, Valentina Bertaina, Giuseppina Li Pira, Stefania Lazzaro, Simone Biagini, Federica Galaverna, Luisa Strocchio, Roberto Carta, Maria Luigia Catanoso, Francesco Quagliarella, Marco Becilli, Emilia Boccieri, Francesca Del Bufalo, Arianna Panigari, Annalisa Agostini, Lucia Pedace, Simone Pizzi, Cesare Perotti, Mattia Algeri, Marco Zecca, Franco Locatelli

https://doi.org/10.3324/haematol.2022.280698

Investigational Venetoclax combination therapy in acute myeloid leukemia – a systematic review and meta-analysis (95 Online Views)

Shai Shimony, Alon Rozental, Jan P. Bewersdorf, Aaron D. Goldberg, Eytan M. Stein, Alyssa A. Grimshaw, Richard M. Stone, Daniel J. DeAngelo, Ofir Wolach, Maximilian Stahl

https://doi.org/10.3324/haematol.2022.281453

Under-representation of ethnic minorities in early phase clinical trials for multiple myeloma (120 Online Views)

Samir Asher, Aikaterini Kazantzi, Fatjon Dekaj, Luke Steventon, Aisha Khatun, Louise Ainley, Annabel McMillan, Neil Rabin, Ashu Wechalekar, Jonathan Sive, Charalampia Kyriakou, Xenofon Papanikolaou, Ke Xu, Shameem Mahmood, Brendan Wisniowski, Lydia Lee, Kwee Yong, Rakesh Popat

https://doi.org/10.3324/haematol.2022.281322

Aug 18, 2022

Articles

High transferrin saturation predicts inferior clinical outcomes in patients with MDS (198 Online Views)

Jennifer Teichman, Michelle Geddes, Nancy Zhu, Mary-Margaret Keating, Mitchell Sabloff, Grace Christou, Brian Leber, Dina Khalaf, Eve St-Hilaire, Nicholas Finn, April Shamy, Karen W.L. Yee, John M. Storring, Thomas J. Nevill, Robert Delage, Mohamed Elemary, Versha Banerji, Brett Houston, Lee Mozessohn, Lisa Chodirker, Liying Zhang, Mohammed Siddiqui, Anne Parmentier, Heather A. Leitch, Rena J. Buckstein

https://doi.org/10.3324/haematol.2022.280723

Selective inhibition of MCL1 overcomes venetoclax-resistance in a murine model of myelodysplastic syndromes (429 Online Views)

Melissa A. Fischer, Yuanbin Song, Maria P. Arrate, Rana Gbyli, Matthew T. Villaume, Brianna N. Smith, Merrida A. Childress, Thomas P. Stricker, Stephanie Halene, Michael R. Savona

https://doi.org/10.3324/haematol.2022.280631

In vivo stabilization of a less toxic asparaginase variant leads to a durable anti-tumor response in acute leukemia (244 Online Views)

Maaike Van Trimpont, Amanda M. Schalk, Yanti De Visser, Hien Anh Nguyen, Lindy Reunes, Katrien Vandemeulebroecke, Evelien Peeters, Ying Su, Hyun Lee, Philip L. Lorenzi, Wai-Kin Chan, Veerle Mondelaers, Barbara De Moerloose, Tim Lammens, Steven Goossens, Pieter Van Vlierberghe, Arnon Lavie

https://doi.org/10.3324/haematol.2022.281390

Letters to the Editor

Circulating endothelial cells and the study of vascular injury in children undergoing hematopoietic stem cell transplant (170 Online Views)

Anthony Sabulski, Sheyar Abdullah, Nathan Luebbering, Benjamin Aunins, Caitlin Castillo, Kelly Lake, Alexandra Duell, Lauren Strecker, Lucille Giordullo, William Broomhead, Scott Dimeo, Elizabeth A. Odegard, Jason T. Blackard, Assem Ziady, Alix E. Seif, Christopher E. Dandoy, Benjamin L. Laskin, Sonata Jodele, Stella M. Davies

https://doi.org/10.3324/haematol.2022.280788

Hematological Historical Vignette

Aug 11, 2022

Articles

Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300 (285 Online Views)

Franziska Hettler, Christina Schreck, Sandra Romero Marquez, Thomas Engleitner, Baiba Vilne, Theresa Landspersky, Heike Weidner, Renate Hausinger, Ritu Mishra, Rupert Oellinger, Martina Rauner, Ronald Naumann, Christian Peschel, Florian Bassermann, Roland Rad, Rouzanna Istvanffy, Robert A.J. Oostendorp

https://doi.org/10.3324/haematol.2022.280760

Molecular monitoring of T-cell kinetics and migration in severe neurotoxicity after real-world CD19-specific chimeric antigen receptor-T cell therapy (1008 Online Views)

Susanna Carolina Berger, Boris Fehse, Nuray Akyüz, Maria Geffken, Christine Wolschke, Dietlinde Janson, Nico Gagelmann, Marlene Luther, Dominic Wichmann, Christian Frenzel, Guenther Thayssen, Anna Alegiani, Anita Badbaran, Silke Zeschke, Judith Dierlamm, Nicolaus Kröger, Francis A. Ayuk

https://doi.org/10.3324/haematol.2022.281110

Potent preclinical activity of FLT3-directed chimeric antigen receptor T cell immunotherapy against FLT3-mutant acute myeloid leukemia and KMT2A-rearranged acute lymphoblastic leukemia (699 Online Views)

Lisa M. Niswander, Zachary T. Graff, Christopher D. Chien, John A. Chukinas, Christina A. Meadows, Lillie C. Leach, Joseph P. Loftus, M. Eric Kohler, Sarah K. Tasian, Terry J. Fry

https://doi.org/10.3324/haematol.2022.281456

Case Reports

Aug 4, 2022

Editorials
Letter to the Editor

Morbidity and mortality of sickle cell disease patients is unaffected by splenectomy: evidence from 3 decades follow-up in a high-income setting (159 Online Views)

Valeria Maria Pinto, Barbara Gianesin, Frédéric B. Piel, Filomena Longo, Paolo Rigano, Alessandra Quota, Vincenzo Spadola, Giovanna Graziadei, Filippo Mazzi, Maria Domenica Cappellini, Aurelio Maggio, Antonio Piga, Lucia De Franceschi, Gian Luca Forni

https://doi.org/10.3324/haematol.2022.280815

Articles

Early expression of CD94 and loss of CD96 on CD8+ T cells after allogeneic SCT is predictive of subsequent relapse and survival (404 Online Views)

Kriti Verma, Wayne Croft, Hayden Pearce, Jianmin Zuo, Christine Stephens, Jane Nunnick, Francesca AM Kinsella, Ram Malladi, Paul Moss

https://doi.org/10.3324/haematol.2021.280497

Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia (219 Online Views)

Elise Sourdeau, Ludovic Suner, Mara Memoli, Alexis Genthon, Frédéric Feger, Lou Soret, Nasséra Abermil, Laurence Heuberger, Chrystele Bilhou-Nabera, Hélène Guermouche, Fabrizia Favale, Simona Lapusan, Michael Chaquin, Claire Hirschauer, Mohamad Mohty, Ollivier Legrand, François Delhommeau, Pierre Hirsch

https://doi.org/10.3324/haematol.2022.280676

Translational readthrough at F8 nonsense variants in factor VIII B domain contributes to residual expression and lowers inhibitor association (235 Online Views)

Maria Francesca Testa, Silvia Lombardi, Francesco Bernardi, Mattia Ferrarese, Donata Belvini, Paolo Radossi, Giancarlo Castaman, Mirko Pinotti, Alessio Branchini

https://doi.org/10.3324/haematol.2022.281279

Letters to the Editor

Onset of blast crisis in chronic myeloid leukemia patients in treatment-free remission (361 Online Views)

Stephanie Dulucq, Sandrine Hayette, Jean-Michel Cayuela, Frédéric Bauduer, Kaddour Chabane, Patrice Chevallier, Pascale Cony-Makhoul, Pascale Flandrin-Gresta, Caroline Le Jeune, Yannick Le Bris, Laurence Legros, Hervé Maisonneuve, Lydia Roy, Francois-Xavier Mahon, Ivan Sloma, Delphine Rea, Franck Emmanuel Nicolini

https://doi.org/10.3324/haematol.2022.280740

Pulmonary function testing for fitness assessment in asymptomatic adults with newly diagnosed acute myeloid leukemia (156 Online Views)

Raffaele Palmieri, Megan Othus, Guang-Shing Cheng, Francesco Buccisano, Giovangiacinto Paterno, Luca Maurillo, Maria Ilaria Del Principe, Giuseppe Sconocchia, Adriano Venditti, Roland B. Walter

https://doi.org/10.3324/haematol.2022.281445

Case Reports

Mass-spectrometry-based proteomics amyloid typing in clinical practice: state-of-the-art from a French nationwide cohort (231 Online Views)

Magali Colombat, Margot Gaspard, Mylène Camus, Jessica Dalloux-Chioccioli, Audrey Delas, Elsa Poullot, Anissa Moktefi, Arnaud François, Anne Moreau, Jean-Bapiste Gibier, Pierre Raynaud, Antoine Huart, Alexis Piedrafita, Julia Gilhodes, Olivier Lairez, Gilles Grateau, Sophie Georgin-Lavialle, Hervé Maisonneuve, Philippe Moreau, Arnaud Jaccard, Franck Bridoux, Violaine Plante-Bordeneuve, Thibaud Damy, Hervé Mal, Pierre Brousset, Sophie Valleix, Odile Burlet-Schiltz

https://doi.org/10.3324/haematol.2022.281431

Jul 28, 2022

Editorials
Article

Improving the anti-acute myeloid leukemia activity of CD123-specific Engager T cells by MyD88 and CD40 costimulation (959 Online Views)

Abishek Vaidya, Erin Doherty, Xiya Wu, Sujuan Huang, Nikhil Hebbar, Unmesha Thanekar, Challice L. Bonifant, Cheng Cheng, Stephen Gottschalk, M. Paulina Velasquez

https://doi.org/10.3324/haematol.2021.279301

Review Articles

Articles

Analysis of rare driving events in pediatric acute myeloid leukemia (394 Online Views)

Sanne Noort, Jolieke van Oosterwijk, Jing Ma, Elizabeth A.R. Garfinkle, Stephanie Nance, Michael Walsh, Guangchun Song, Dirk Reinhardt, Martina Pigazzi, Franco Locatelli, Henrik Hasle, Jonas Abrahamsson, Marie Jarosova, Charikleia Kelaidi, Sophia Polychronopoulou, Marry M. van den Heuvel-Eibrink, Maarten Fornerod, Tanja A. Gruber, C. Michel Zwaan

https://doi.org/10.3324/haematol.2021.280250

Letters to the Editor

Minnesota acute GvHD risk score predicts survival at onset of GvHD after PTCy prophylaxis (241 Online Views)

Federica Ardizzoia, Francesca Lorentino, Alessandro Bruno, Sarah Marktel, Fabio Giglio, Daniela Clerici, Francesca Farina, Sara Mastaglio, Simona Piemontese, Andrea A. Assanelli, Matteo G. Carrabba, Massimo Bernardi, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri, Raffaella Greco, Maria Teresa Lupo-Stanghellini

https://doi.org/10.3324/haematol.2022.281269

Case Reports

Acute myeloid leukemia early after anti-CD19 chimeric antigen receptor T cells infusion in a patient with refractory diffuse large B cell lymphoma and pre-existing clonal hematopoiesis (377 Online Views)

Lorenza Falini, Alessandra Venanzi, Valentina Tini, Alessandra Innocente, Stelvio Ballanti, Simonetta Saldi, Silvio Sivolella, Antonio Pierini, Cynthia Aristei, Enrico Tiacci, Vincenzo Maria Perriello, Brunangelo Falini

https://doi.org/10.3324/haematol.2022.281351

Jul 21, 2022

Editorials
Article

Hypercortisolemic Cushing's patients possess a distinct class of hematopoietic progenitor cells leading to erythrocytosis (387 Online Views)

Lilian Varricchio, Eliza B Geer, Fabrizio Martelli, Maria Mazzarini, Alister Funnell, James J Bieker, Thalia Papayannopoulou, Anna Rita Migliaccio

https://doi.org/10.3324/haematol.2021.280542

Editorials
Article

Time spent at home among older adults with acute myeloid leukemia receiving azacitidine- or venetoclax-based regimens (414 Online Views)

Christopher E. Jensen, Hilary M. Heiling, Konan E. Beke, Allison M. Deal, Ashley L. Bryant, Lorinda A. Coombs, Matthew C. Foster, Daniel R. Richardson

https://doi.org/10.3324/haematol.2022.280728

Letters to the Editor

Guidelines

Thrombosis in multiple myeloma: risk stratification, antithrombotic prophylaxis, and management of acute events. A consensus-based position paper from an ad hoc expert panel (364 Online Views)

Valerio De Stefano, Alessandra Larocca, Monica Carpenedo, Michele Cavo, Francesco Di Raimondo, Anna Falanga, Massimo Offidani, Maria Teresa Petrucci, Marco Ruggeri, Roberto Mario Santi, Giovanni Barosi

https://doi.org/10.3324/haematol.2022.280893

Jul 14, 2022

Editorials

Articles

RHOA regulated IGFBP2 promotes invasion and drives progression of BCR-ABL1 chronic myeloid leukemia (536 Online Views)

Hualei Zhang, Baohuan Cai, Yun Liu, Yating Chong, Atsuko Matsunaga, Stephanie Fay Mori, Xuexiu Fang, Eiko Kitamura, Chang-Sheng Chang, Ping Wang, John K Cowell, Tianxiang Hu

https://doi.org/10.3324/haematol.2022.280757

Allogeneic transplant following CAR T-cell therapy for large B-cell lymphoma (1112 Online Views)

Joanna Zurko, Jeremy Ramdial, Mazyar Shadman, Sairah Ahmed, Aniko Szabo, Lorenzo Iovino, Ana Alarcon Tomas, Craig Sauter, Miguel-Angel Perales, Nirav. N. Shah, Utkarsh H. Acharya, Caron Jacobson, Robert J. Soiffer, Trent Wang, Krishna V. Komanduri, Samantha Jaglowski, Adam S. Kittai, Nathan Denlinger, Madiha Iqbal, Mohamed A. Kharfan-Dabaja, Ernesto Ayala, Julio Chavez, Michael Jain, Frederick L. Locke, Yazeed Samara, Lihua E. Budde, Matthew G. Mei, Alexandra Della Pia, Tatyana Feldman, Nausheen Ahmed, Ryan Jacobs, Nilanjan Ghosh, Bhagirathbhai Dholaria, Olalekan O. Oluwole, Brian Hess, Ayesha Hassan, Vaishalee P. Kenkre, Patrick Reagan, Farrukh Awan, Yago Nieto, Mehdi Hamadani, Alex F. Herrera

https://doi.org/10.3324/haematol.2022.281242

Letters to the Editor

Histological, genetic characterization and follow-up of 130 patients with chronic triplenegative thrombocytosis. (566 Online Views)

Sandrine Lemoine, Clelia Mornet, Isabelle Quintin-Roue, Marie-Christine Rousselet, Laurane Cottin, Aurélie Georgeais, Ludovic Dubouis, Françoise Boyer, Corentin Orvain, Clara Caillon, Maxime Renard, Valoris Le Brun, Lenaig Le Clech, Jean-Christophe Ianotto, Emmanuelle Génin, Barbara Burroni, Valérie Ugo, Damien Luque Paz, Eric Lippert

https://doi.org/10.3324/haematol.2022.280917

Extranodal presentation in limited stage diffuse large B-cell lymphoma as a prognostic marker in three SWOG trials S0014, S0313 and S1001 (241 Online Views)

Deborah M. Stephens, Hongli Li, Louis S. Constine, Thomas J. Fitzgerald, John P. Leonard, Brad S. Kahl, Joo Y. Song, Michael L. LeBlanc, Sonali M. Smith, Daniel O. Persky, Jonathan W. Friedberg

https://doi.org/10.3324/haematol.2022.281004

Inflammation in Waldenström macroglobulinemia is associated with 6q deletion and need for treatment initiation (247 Online Views)

Nathalie Forgeard, Marine Baron, Jonathan Caron, Clementine Boccon-Gibod, Daphne Krzisch, Nayara Guedes, Veronique Morel, Nathalie Jacque, Maya Ouzegdouh, Sylvain Choquet, Clotilde Bravetti, Florence Nguyen-Khac, Elise Chapiro, Veronique Leblond, Damien Roos-Weil

https://doi.org/10.3324/haematol.2022.281053

Jul 7, 2022

Articles

Comparative analysis of oral and intravenous iron therapy in rat models of inflammatory anemia and iron deficiency (711 Online Views)

Lara Valente de Souza, Alexander Hoffmann, Christine Fischer, Verena Petzer, Malte Asshoff, Igor Theurl, Piotr Tymoszuk, Markus Seifert, Natascha Brigo, Richard Hilbe, Egon Demetz, Laura Von Raffay, Sylvia Berger, Marina Barros-Pinkelnig, Guenter Weiss

https://doi.org/10.3324/haematol.2022.281149

Letters to the Editor

Association of FLT3-ITD length with overall survival in acute myeloid leukemia: a systematic review and meta-analysis (579 Online Views)

Tobias B. Polak, Joost van Rosmalen, Stijn Dirven, Julia K. Herzig, Jacqueline Cloos, Soheil Meshinchi, Konstanze Döhner, Jeroen J.W.M. Janssen, David G.J. Cucchi

https://doi.org/10.3324/haematol.2022.281218

Platelet functional abnormalities and clinical presentation in pediatric patients with germline RUNX1, ANKRD26, and ETV6 mutations (855 Online Views)

Galina S. Ovsyannikova, Daria V. Fedorova, Ivan P. Tesakov, Alexey A. Martyanov, Anastasia A. Ignatova, Evgeniya A. Ponomarenko, Pavel A. Zharkov, Anna V. Pavlova, Elena V. Raykina, Michael A. Maschan, Mikhail A. Panteleev, Galina A. Novichkova, Anastasia N. Sveshnikova, Nataliya S. Smetanina

https://doi.org/10.3324/haematol.2022.281340

Case Reports

Jun 30, 2022

Editorials
Article

Comparison of autologous and allogeneic hematopoietic cell transplantation strategies in patients with primary plasma cell leukemia, with dynamic prediction modelling (628 Online Views)

Sarah Lawless, Simona Iacobelli, Nina Simone Knelange, Patrice Chevallier, Didier Blaise, Noel Milpied, Roberto Foà, Jan J. Cornelissen, Bruno Lioure, Ruben Benjamin, Xavier Poiré, Monique C. Minnema, Matthew Collin, Stig Lenhoff, John A. Snowden, Stella Santarone, Keith M. O. Wilson, Fernanda Trigo, Peter Dreger, Lara H. Böhmer, Hein Putter, Laurent Garderet, Nicolaus Kröger, Ibrahim Yaukoub-Agha, Stefan Schönland, Curly Morris

https://doi.org/10.3324/haematol.2021.280568

Editorials
Article

Comparison of autologous and allogeneic hematopoietic cell transplantation strategies in patients with primary plasma cell leukemia, with dynamic prediction modelling (628 Online Views)

Sarah Lawless, Simona Iacobelli, Nina Simone Knelange, Patrice Chevallier, Didier Blaise, Noel Milpied, Roberto Foà, Jan J. Cornelissen, Bruno Lioure, Ruben Benjamin, Xavier Poiré, Monique C. Minnema, Matthew Collin, Stig Lenhoff, John A. Snowden, Stella Santarone, Keith M. O. Wilson, Fernanda Trigo, Peter Dreger, Lara H. Böhmer, Hein Putter, Laurent Garderet, Nicolaus Kröger, Ibrahim Yaukoub-Agha, Stefan Schönland, Curly Morris

https://doi.org/10.3324/haematol.2021.280568

Articles

Combination elotuzumab and lenalidomide treatment efficacy is dependent on crosstalk between NK cells, monocytes and myeloma cells (497 Online Views)

Kelden Richardson, Simon P. Keam, Joe Jiang Zhu, Deborah Meyran, Criselle D’Souza, Sean Macdonald, Kerry Campbell, Michael Robbins, Natalie A. Bezman, Kirsten Todd, Hang Quach, David S. Ritchie, Simon J. Harrison, H. Miles Prince, Joseph A. Trapani, Misty R. Jenkins, Paul A. Beavis, Phillip K. Darcy, Paul J. Neeson

https://doi.org/10.3324/haematol.2021.279930

Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma (1837 Online Views)

Mi Kwon, Gloria Iacoboni, Juan Luis Reguera, Lucía López Corral, Rafael Hernani Morales, Valentín Ortiz-Maldonado, Manuel Guerreiro, Ana Carolina Caballero, María Luisa Guerra Domínguez, Jose Maria Sanchez Pina, Alberto Mussetti, Juan Manuel Sancho, Mariana Bastos-Oreiro, Eva Catala, Javier Delgado, Hugo Luzardo Henriquez, Jaime Sanz, María Calbacho, Rebeca Bailén, Cecilia Carpio, Jose Maria Ribera, Anna Sureda, Javier Briones, Juan Carlos Hernandez-Boluda, Nuria Martínez Cebrián, Jose Luis Diez Martin, Alejandro Martín, Pere Barba

https://doi.org/10.3324/haematol.2022.280805

Clinical features of hepatitis E infections in patients with hematological disorders (312 Online Views)

Susanne Ghandili, Cecilia Lindhauer, Sven Pischke, Julian Schulze zur Wiesch, Philipp H. von Kroge, Susanne Polywka, Carsten Bokemeyer, Walter Fiedler, Nicolaus Kröger, Francis Ayuk, Raissa Adjallé, Franziska Modemann

https://doi.org/10.3324/haematol.2022.280853

Letters to the Editor

Myeloablative fractionated busulfan conditioning regimen with post-transplant cyclophosphamide in HLA matched and haploidentical transplantation: results of a phase II study (229 Online Views)

Uday R. Popat, Borje S Andersson, Roland Bassett, Jitesh Kawedia, Ben C. Valdez, Amin M. Alousi, Gheath Al-Atrash, Qaiser Bashir, Chitra M. Hosing, Jin S. Im, Partow Kebriaei, David Marin, Yago Nieto, Betul Oran, Amanda Olson, Muzaffar H. Qazilbash, Samer A. Srour, Elizabeth J. Shpall, Richard E. Champlin, Rohtesh S. Mehta

https://doi.org/10.3324/haematol.2022.280778

Molecular predictors of response to venetoclax plus hypomethylating agent in treatment-naïve acute myeloid leukemia (587 Online Views)

Naseema Gangat, Isla Johnson, Kristen McCullough, Faiqa Farrukh, Aref Al-Kali, Hassan Alkhateeb, Kebede Begna, Abhishek Mangaonkar, Mark Litzow, William Hogan, Mithun Shah, Mrinal Patnaik, Animesh Pardanani, Ayalew Tefferi

https://doi.org/10.3324/haematol.2022.281214

Jun 23, 2022

Editorials
Article

STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment (406 Online Views)

Jordy C.G. van der Zwet, Valentina Cordo’, Jessica G.C.A.M. Buijs-Gladdines, Rico Hagelaar, Willem K. Smits, Eric Vroegindeweij, Laura T.M. Graus, Vera Poort, Marloes Nulle, Rob Pieters, Jules P.P. Meijerink

https://doi.org/10.3324/haematol.2021.280405

Articles

Impaired immunosuppressive role of myeloid-derived suppressor cells in acquired aplastic anemia (563 Online Views)

Peiyuan Dong, Lingyun Chen, Hongfei Wu, Jiali Huo, Zhongxing Jiang, Yingqi Shao, Xiang Ren, Jinbo Huang, Xingxin Li, Min Wang, Neng Nie, Jing Zhang, Peng Jin, Yizhou Zheng, Meili Ge

https://doi.org/10.3324/haematol.2021.280292

In-depth characterization of intratumoral heterogeneity in refractory B-cell non-Hodgkin lymphoma through the lens of a Research Autopsy Program (290 Online Views)

Keren Isaev, Ting Liu, Mehran Bakhtiari, Kit Tong, Rashmi Goswami, Bernard Lam, Ilinca Lungu, Paul M. Krzyzanowski, Amit Oza, Neesha Dhani, Anca Prica, Michael Crump, Robert Kridel

https://doi.org/10.3324/haematol.2022.280900

Letters to the Editor

A phase I/II multicenter, open-label, dose escalation and randomized trial of BI 836858 in patients with low or intermediate-1 risk myelodysplastic syndrome (297 Online Views)

Rami S. Komrokji, Hetty E. Carraway, Ulrich Germing, Martin Wermke, Amer M. Zeidan, Eric Fu, Björn Rüter, Ute Burkard, Annika Osswald, James M. Foran

https://doi.org/10.3324/haematol.2021.280500

Primary outcomes by 1q21+ status for isatuximab-treated patients with relapsed/refractory multiple myeloma: Subgroup analyses from ICARIA-MM and IKEMA (1727 Online Views)

Tom Martin, Paul G Richardson, Thierry Facon, Philippe Moreau, Aurore Perrot, Ivan Spicka, Kamlesh Bisht, Marlene Inchauspé, France Casca, Sandrine Macé, Helgi van de Velde, Kenshi Suzuki

https://doi.org/10.3324/haematol.2022.280660

COVID-19 vaccine-induced adverse events predict immunogenicity among recipients of allogeneic haematopoietic stem cell transplantation (242 Online Views)

Hanna Grauers Wiktorin, Sigrun Einarsdottir, Andreas Törnell, Mohammad Arabpour, Nuttida Issdisai, Jesper Waldenström, Johan Ringlander, Magnus Lindh, Martin Lagging, Kristoffer Hellstrand, Anna Martner

https://doi.org/10.3324/haematol.2022.280813

SARS-CoV-2-specific cellular response following third COVID-19 vaccination in patients with chronic lymphocytic leukemia (313 Online Views)

Sibylle C. Mellinghoff, Leonie Mayer, Sandra Robrecht, Leonie M. Weskamm, Christine Dahlke, Henning Gruell, Maike Schlotz, Kanika Vanshylla, Hans A. Schloser, Martin Thelen, Anna-Maria Fink, Kirsten Fischer, Florian Klein, Marylyn M. Addo, Barbara Eichhorst, Michael Hallek, Petra Langerbeins

https://doi.org/10.3324/haematol.2022.280982

Daunorubicin-60 vs daunorubicin-90 vs idarubicin-12 for induction chemotherapy in acute myeloid leukemia: a retrospective analysis of the Mayo Clinic experience (297 Online Views)

Ayalew Tefferi, Naseema Gangat, Mithun Shah, Hassan Alkhateeb, Mrinal S. Patnaik, Aref Al-Kali, Michelle A. Elliott, William J. Hogan, Mark R. Litzow, Christopher C. Hook, Abhishek Mangaonkar, David Viswanatha, Dong Chen, Animesh Pardanani, Rhett P. Ketterling, Kebede H. Begna

https://doi.org/10.3324/haematol.2022.281045

Case Reports

Jun 16, 2022

Editorials
Article

Prediction of complete remission and survival in acute myeloid leukemia using supervised machine learning (691 Online Views)

Jan-Niklas Eckardt, Christoph Röllig, Klaus Metzeler, Michael Kramer, Sebastian Stasik, Julia-Annabell Georgi, Peter Heisig, Karsten Spiekermann, Utz Krug, Jan Braess, Dennis Görlich, Cristina M. Sauerland, Bernhard Woermann, Tobias Herold, Wolfgang E. Berdel, Wolfgang Hiddemann, Frank Kroschinsky, Johannes Schetelig, Uwe Platzbecker, Carsten Müller-Tidow, Tim Sauer, Hubert Serve, Claudia Baldus, Kerstin Schäfer-Eckart, Martin Kaufmann, Stefan Krause, Mathias Hänel, Christoph Schliemann, Maher Hanoun, Christian Thiede, Martin Bornhäuser, Karsten Wendt, Jan Moritz Middeke

https://doi.org/10.3324/haematol.2021.280027

Articles

Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome (500 Online Views)

Luis Veloza, Doriane Cavalieri, Edoardo Missiaglia, Albane Ledoux-Pilon, Bettina Bisig, Bruno Pereira, Christophe Bonnet, Elsa Poullot, Leticia Quintanilla-Martinez, Romain Dubois, Francisco Llamas-Gutierrez, Céline Bossard, Roland De Wind, Fanny Drieux, Juliette Fontaine, Marie Parrens, Jeremy Sandrini, Virginie Fataccioli, Marie-Hélène Delfau-Larue, Adrien Daniel, Faustine Lhomme, Lauriane Clément-Filliatre, François Lemonnier, Anne Cairoli, Pierre Morel, Sylvie Glaisner, Bertrand Joly, Abderrazak El Yamani, Kamel Laribi, Emmanuel Bachy, Reiner Siebert, David Vallois, Philippe Gaulard, Olivier Tournilhac, Laurence de Leval

https://doi.org/10.3324/haematol.2022.281226

Jun 9, 2022

Articles

PET-imaging assessment for guiding strategy in patients with relapsed/refractory large B-cell lymphoma receiving CAR T-cells (512 Online Views)

Jean Galtier, Laetitia Vercellino, Loic Chartier, Pierre Olivier, Claire Tabouret-Viaud, Charles Mesguich, Roberta Di Blasi, Amandine Durand, Léo Raffy, François-Xavier Gros, Isabelle Madelaine, Veronique Meignin, Miryam Mebarki, Marie-Thérèse Rubio, Pierre Feugier, Olivier Casasnovas, Michel Meignan, Catherine Thieblemont

https://doi.org/10.3324/haematol.2021.280550

Characteristics and outcome of patients with acute myeloid leukemia and trisomy 4 (383 Online Views)

Sabine Kayser, David Martínez-Cuadrón, Maher Hanoun, Friedrich Stölzel, Cristina Gil, H. Christian Reinhardt, Eliana Aguiar, Kerstin Schäfer-Eckart, Juan Miguel Bergua Burgues, Björn Steffen, Teresa Bernal, Stefan W. Krause, Rosalía Riaza, Christoph Schliemann, Jose Cervera, Martin Kaufmann, Laura Torres-Miñana, Mathias Hänel, Evelyn Acuña-Cruz, Edgar Jost, Jesus Lorenzo Algarra, Martina Crysandt, Lars Fransecky, Javier Cornago-Navascues, Sabrina Kraus, Joaquin Martinez-Lopez, Hermann Einsele, Dirk Niemann, Andreas Neubauer, Ruth Seggewiß-Bernhardt, Sebastian Scholl, Stefan A. Klein, Christoph Schmid, Markus Schaich, Martin Schmidt-Hieber, Sven Zukunft, Anthony D. Ho, Uwe Platzbecker, Claudia D. Baldus, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Hubert Serve, Mark Levis, Pau Montesinos, Christoph Röllig, Richard F. Schlenk

https://doi.org/10.3324/haematol.2022.281137

Case Reports

May 31, 2022

Editorials
Article

APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis (599 Online Views)

Simon Stritt, Paquita Nurden, Alan T. Nurden, Jean-François Schved, Jean-Claude Bordet, Maguelonne Roux, Marie-Christine Alessi, David-Alexandre Trégouët, Taija Mäkinen, Muriel Giansily-Blaizot

https://doi.org/10.3324/haematol.2022.280816

Articles

High-risk stage IIB Hodgkin lymphoma treated in the H10 and AHL2011 trials: TMTV is a useful risk factor to stratify patients at baseline (468 Online Views)

Cédric Rossi, Marc André, Jehan Dupuis, Franck Morschhauser, Bertrand Joly, Julien Lazarovici, Hervé Ghesquières, Aspasia Stamatoullas, Emmanuelle Nicolas-Virelizier, Pierre Feugier, Anne-Claire Gac, Hannah Moatti, Luc-Matthieu Fornecker, Bénédicte Deau, Clémentine Joubert, Catherine Fortpied, John Raemaekers, Massimo Federico, Salim Kanoun, Michel Meignan, Alexandra Traverse-Glehen, Anne-Ségolène Cottereau, René-Olivier Casasnova

https://doi.org/10.3324/haematol.2021.280004

May 26, 2022

Editorials
Article

Durable discontinuation of systemic therapy in patients affected by chronic graft-versus-host disease (1163 Online Views)

George L. Chen, Lynn Onstad, Paul J. Martin, Paul Carpenter, Joseph Pidala, Sally Arai, Corey Cutler, Betty K. Hamilton, Stephanie J. Lee, Mukta Arora

https://doi.org/10.3324/haematol.2021.279814

Editorials
Article

Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease (362 Online Views)

Iryna A. Khasabova, Jacob Gable, Malcolm Johns, Sergey G. Khasabov, Alexander E. Kalyuzhny, Mikhail Y. Golovko, Svetlana A. Golovko, Stacy Kiven, Kalpna Gupta, Virginia S. Seybold, Donald A. Simone

https://doi.org/10.3324/haematol.2021.280460

Articles

Regulation of Human T-cell leukemia virus type 1 antisense promoter by myocyte enhancer factor-2C in the context of adult T-cell leukemia and lymphoma (474 Online Views)

Kiran K. Madugula, Julie Joseph, Catherine DeMarino, Rashida Ginwala, Vanessa Teixeira, Zafar K. Khan, Dominic Sales, Sydney Wilson, Fatah Kashanchi, Amanda W. Rushing, Isabelle Lemasson, Edward W. Harhaj, Murali Janakiram, B. Hilda Ye, Pooja Jain

https://doi.org/10.3324/haematol.2021.279542

Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells (501 Online Views)

Sarah Warsi, Maria Dahl, Emma M. K. Smith, Anna Rydstrom, Els Mansell, Valgardur Sigurdsson, Julia Sjoberg, Shamit Soneji, Emma Rorby, Kavitha Siva, Tan H. M. Grahn, Yang Liu, Ulrika Blank, Goran Karlsson, Stefan Karlsson

https://doi.org/10.3324/haematol.2021.279799

Comparable long-term outcomes between upfront haploidentical and identical sibling donor transplant in aplastic anemia: a national registry-based study (961 Online Views)

Zheng-Li Xu, Lan-Ping Xu, De-Pei Wu, Shun-Qing Wang, Xi Zhang, Rui Xi, Su-Jun Gao, Ling-Hui Xia, Jian-Min Yang, Ming Jiang, Xin Wang, Qi-Fa Liu, Jia Chen, Ming Zhou, Xiao-Jun Huang

https://doi.org/10.3324/haematol.2022.280758

Kinetics of early and late molecular recurrences after first-line imatinib cessation in chronic myeloid leukemia: updated results from the STIM2 trial (360 Online Views)

Stéphanie Dulucq, Franck E. Nicolini, Delphine Rea, Pascale Cony-Makhoul, Aude Charbonnier, Martine Escoffre-Barbe, Valérie Coiteux, Pascal Lenain, Françoise Rigal-Huguet, Jixing Liu, Agnès Guerci-Bresler, Laurence Legros, Jean-Christophe Ianotto, Martine Gardembas, Pascal Turlure, Viviane Dubruille, Philippe Rousselot, Juliana Martiniuc, Henry Jardel, Hyacinthe Johnson-Ansah, Bertrand Joly, Tawfiq Henni, Emilie Cayssials, Patricia Zunic, Marc G. Berger, Bruno Villemagne, Fanny Robbesyn, Stephane Morisset, François-Xavier Mahon, Gabriel Etienne

https://doi.org/10.3324/haematol.2022.280811

Case Reports

The successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARS-CoV2 infection and multisystem inflammatory syndrome in children (347 Online Views)

Tarun Aurora, Noel Joseph, Senthil Velan Bhoopalan, Miguela A. Caniza, Tim Flerlage, Saad Ghafoor, Jane Hankins, Diego R. Hijano, Rohith Jesudas, Justin Kirkham, Hugo Martinez, Gabriela Maron Alfaro, Akshay Sharma, Melissa Hines

https://doi.org/10.3324/haematol.2022.280603

May 19, 2022

Editorials
Article

Impact of PET-CT status on progression-free survival for relapsed follicular lymphoma patients undergoing autologous stem cell transplant (501 Online Views)

Toby A. Eyre, Sally F. Barrington, Jessica Okosun, Clementina Abamba, Rachel M. Pearce, Julia Lee, Ben Carpenter, Charles R. Crawley, Adrian J.C. Bloor, Maria Gilleece, Emma Nicholson, Nimish Shah, Kim Orchard, Ram Malladi, William M. Townsend

https://doi.org/10.3324/haematol.2021.280287

May 12, 2022

Editorials
Letter to the Editor

Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation (413 Online Views)

Annalisa Ruggeri, Liesbeth C. de Wreede, Carlheinz R. Müller, Pietro Crivello, Edouard F. Bonneville, Effie W. Petersdorf, Gerard Socié, Valérie Dubois, Riitta Niittyvuopio, Juha Peräsaari, Ibrahim Yakoub-Agha, Jan J. Cornelissen, Lotte Wieten, Tobias Gedde-Dahl, Edouard Forcade, Charles R. Crawley, Steven G.E. Marsh, Virginie Gandemer, Eleni Tholouli, Claude-Eric Bulabois, Anne Huynh, Goda Choi, Eric Deconinck, Maija Itäla-Remes, Stig Lenhoff, Mats Bengtsson, Jan-Erik Johansson, Gwendolyn van Gorkom, Jorinde D. Hoogenboom, Luca Vago, Vanderson Rocha, Chiara Bonini, Christian Chabannon, Katharina Fleischhauer

https://doi.org/10.3324/haematol.2021.280055

Articles

Assessment of functional shunting in patients with sickle cell disease (318 Online Views)

Liza Afzali-Hashemi, Lena Václavů, John C. Wood, Bart J. Biemond, Aart J. Nederveen, Henk J.M.M. Mutsaerts, Anouk Schrantee

https://doi.org/10.3324/haematol.2021.280183

COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA) (1100 Online Views)

Francesco Marchesi, Jon Salmanton-García, Ziad Emarah, Klára Piukovics, Marcio Nucci, Alberto López-García, Zdeněk Ráčil, Francesca Farina, Marina Popova, Sofia Zompi, Ernesta Audisio, Marie-Pierre Ledoux, Luisa Verga, Barbora Weinbergerová, Tomas Szotkovski, Maria Gomes Da Silva, Nicola Fracchiolla, Nick De Jonge, Graham Collins, Monia Marchetti, Gabriele Magliano, Carolina García-Vidal, Monika M. Biernat, Jaap Van Doesum, Marina Machado, Fatih Demirkan, Murtadha Al-Khabori, Pavel Žák, Benjamín Víšek, Igor Stoma, Gustavo-Adolfo Méndez, Johan Maertens, Nina Khanna, Ildefonso Espigado, Giulia Dragonetti, Luana Fianchi, Maria Ilaria Del Principe, Alba Cabirta, Irati Ormazabal-Vélez, Ozren Jaksic, Caterina Buquicchio, Valentina Bonuomo, Josip Batinić, Ali S. Omrani, Sylvain Lamure, Olimpia Finizio, Noemí Fernández, Iker Falces-Romero, Ola Blennow, Rui Bergantim, Natasha Ali, Sein Win, Jens Van Praet, Maria Chiara Tisi, Ayten Shirinova, Martin Schönlein, Juergen Prattes, Monica Piedimonte, Verena Petzer, Milan Navrátil, Austin Kulasekararaj, Pavel Jindra, Jiří Sramek, Andreas Glenthøj, Rita Fazzi, Cristina De Ramón-Sánchez, Chiara Cattaneo, Maria Calbacho, Nathan C. Bahr, Shaimaa El-Ashwah, Raul Cordoba, Michaela Hanakova, Giovanni Zambrotta, Mariarita Sciumè, Stephen Booth, Raquel Nunes Rodrigues, Maria Vittoria Sacchi, Nicole García-Poutón, Juan-Alberto Martín-González, Sofya Khostelidi, Stefanie Gräfe, Laman Rahimli, Emanuele Ammatuna, Alessandro Busca, Paolo Corradini, Martin Hoenigl, Nikolai Klimko, Philipp Koehler, Antonio Pagliuca, Francesco Passamonti, Oliver A. Cornely, Livio Pagano

https://doi.org/10.3324/haematol.2022.280847

May 5, 2022

Articles

Patient- and physician-reported pain after tyrosine kinase inhibitor discontinuation among patients with chronic myeloid leukemia (684 Online Views)

Kathryn E Flynn, Ehab Atallah, Li Lin, Neil P Shah, Richard T Silver, Richard A. Larson, Javier Panilla-Ibarz, James E. Thompson, Vivian G. Oehler, Jerald P. Radich, Vamsi Kota, Michael J Mauro, Charles A Schiffer, Jorge Cortes, Kevin P Weinfurt

https://doi.org/10.3324/haematol.2021.280377

Relapse of immune-mediated thrombotic thrombocytopenic purpura following mRNA COVID-19 vaccination: a prospective cohort study (771 Online Views)

Gaetano Giuffrida, Uros Markovic, Annalisa Condorelli, Marianna Calagna, Stephanie Grasso, Andrea Duminuco, Carla Riccobene, Angelo Curto Pelle, Guido Zanghi, Francesco Di Raimondo

https://doi.org/10.3324/haematol.2022.280702

Apr 28, 2022

Editorials
Article

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas (665 Online Views)

Cristina Lopez, Nikolai Schleussner, Stephan H. Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L. Sczakiel, Helene Kretzmer, Umut H. Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C. Gonzalez Sanchez, Gordana Apic, Daniel Hubschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M. Muller, Julian Seufert, Steve Hoffmann, Jan O. Korbel, Robert B. Russell, Roland Schule, Lorenz Trumper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kuppers, Matthias Schlesner, Stephan Mathas, Reiner Siebert

https://doi.org/10.3324/haematol.2021.280005

Editorials

Editorials

Editorials
Article

Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement (816 Online Views)

Simon Bomken, Amir Enshaei, Edward C. Schwalbe, Aneta Mikulasova, Yunfeng Dai, Masood Zaka, Kent T.M. Fung, Matthew Bashton, Huezin Lim, Lisa Jones, Nefeli Karataraki, Emily Winterman, Cody Ashby, Andishe Attarbaschi, Yves Bertrand, Jutta Bradtke, Barbara Buldini, G.A. Amos Burke, Giovanni Cazzaniga, Gudrun Gohring, Hesta A. de Groot-Kruseman, Claudia Haferlach, Luca Lo Nigro, Mayur Parihar, Adriana Plesa, Emma Seaford, Edwin Sonneveld, Sabine Strehl, Vincent H.J. van der Velden, Vikki Rand, Stephen P. Hunger, Christine J. Harrison, Chris M. Bacon, Frederik W. van Delft, Mignon L. Loh, John Moppett, Josef Vormoor, Brian A. Walker, Anthony V. Moorman, Lisa J. Russell

https://doi.org/10.3324/haematol.2021.280557

Articles

Resistance to PI3κδ inhibitors in marginal zone lymphoma can be reverted by targeting the IL-6/PDGFRA axis (1257 Online Views)

Alberto J. Arribas, Sara Napoli, Luciano Cascione, Giulio Sartori, Laura Barnabei, Eugenio Gaudio, Chiara Tarantelli, Afua Adjeiwaa Mensah, Filippo Spriano, Antonella Zucchetto, Francesca M Rossi, Andrea Rinaldi, Manuel Castro de Moura, Sandra Jovic, Roberta Bordone-Pittau, Alessandra Di Veroli, Anastasios Stathis, Gabriele Cruciani, Georg Stussi, Valter Gattei, Jennifer R Brown, Manel Esteller, Emanuele Zucca, Davide Rossi, Francesco Bertoni

https://doi.org/10.3324/haematol.2021.279957

Total late effect burden in long-term lymphoma survivors after high-dose therapy with autologous stem-cell transplant and its effect on health-related quality of life (884 Online Views)

Knut Smeland, Harald Holte, Unn-Merete Fagerli, Hanne Bersvendsen, Marianne J. Hjermstad, Jon H. Loge, Klaus Murbrach, Marianne D. Linnsund, Oystein Fluge, Jo S. Stenehjem, May B. Lund, Stein Kvaloy, Cecilie E. Kiserud

https://doi.org/10.3324/haematol.2021.280413

Phenotypic and functional characterization of the CD6-ALCAM T cell costimulatory pathway after allogeneic cell transplantation (685 Online Views)

Benedetta Rambaldi, Haesook T. Kim, Yohei Arihara, Takeru Asano, Carol Reynolds, Mariah Manter, Max Halpern, Augustine Weber, John Koreth, Corey Cutler, Mahasweta Gooptu, Sarah Nikiforow, Vincent T. Ho, Joseph H. Antin, Rizwan Romee, Jeanette Ampudia, Cherie Ng, Stephen Connelly, Robert J. Soiffer, Jerome Ritz

https://doi.org/10.3324/haematol.2021.280444

Erdheim-Chester disease: look it in the eye. An orbital MRI study (299 Online Views)

Julien Haroche, Yoram Gueniche, Damien Galanaud, Fleur Cohen-Aubart, Didier Dormont, Théophile Rousseau, Zahir Amoura, Valerie Touitou, Natalia Shor

https://doi.org/10.3324/haematol.2021.280510

Apr 21, 2022

Editorials
Article

The mutational landscape in chronic myelomonocytic leukemia and its impact on allogeneic hematopoietic cell transplantation outcomes: a Center for Blood and Marrow Transplantation Research (CIBMTR) analysis (1418 Online Views)

Matthew Mei, Raju Pillai, Soyoung Kim, Noel Estrada-Merly, Michelle Afkhami, Lixin Yang, Zhuo Meng, Muhammad Bilal Abid, Mahmoud Aljurf, Ulrike Bacher, Amer Beitinjaneh, Christopher Bredeson, Jean-Yves Cahn, Jan Cerny, Edward Copelan, Corey Cutler, Zachariah DeFilipp, Miguel Angel Diaz Perez, Nosha Farhadfar, César O. Freytes, Shahinaz M. Gadalla, Siddhartha Ganguly, Robert Peter Gale, Usama Gergis, Michael R. Grunwald, Betty K. Hamilton, Shahrukh Hashmi, Gerhard C. Hildebrandt, Hillard M. Lazarus, Mark Litzow, Reinhold Munker, Hemant S. Murthy, Sunita Nathan, Taiga Nishihori, Sagar S. Patel, David Rizzieri, Sachiko Seo, Mithun Vinod Shah, Melhem Solh, Leo F. Verdonck, Ravi Vij, Ronald M. Sobecks, Betul Oran, Bart L. Scott, Wael Saber, Ryotaro Nakamura

https://doi.org/10.3324/haematol.2021.280203

Editorials
Letter to the Editor

Crosstalk between β-catenin and WT1 signalling activity in acute myeloid leukemia (627 Online Views)

Megan Wagstaff, Olga Tsaponina, Gilian Caalim, Hayley Greenfield, Leanne Milton-Harris, Erika J Mancini, Allison Blair, Kate J Heesom, Alex Tonks, Richard L Darley, Stefan G Roberts, Rhys G Morgan

https://doi.org/10.3324/haematol.2021.280294

Articles

Evidence of protective effects of recombinant ADAMTS13* in humanized model for sickle cell disease (489 Online Views)

Paolo Rossato, Enrica Federti, Alessandro Matte, Helmut Glantschnig, Fabio Canneva, Maria Schuster, Sogue Coulibaly, Gerald Schrenk, Dirk Voelkel, Michael Dockal, Barbara Plaimauer, Immacolata Andolfo, Achille Iolascon, Hanspeter Rottensteiner, Herbert Gritsch, Friedrich Scheiflinger, Werner Hoellriegl, Lucia De Franceschi

https://doi.org/10.3324/haematol.2021.280233

Apr 14, 2022

Editorials

Articles

Genomic determinants impacting the clinical outcome of mogamulizumab treatment for adult T-cell leukemia/lymphoma (580 Online Views)

Norio Tanaka, Seiichi Mori, Kazuma Kiyotani, Yuki Ota, Osamu Gotoh, Shigeru Kusumoto, Nobuaki Nakano, Youko Suehiro, Asahi Ito, Ilseung Choi, Eiichi Ohtsuka, Michihiro Hidaka, Kisato Nosaka, Makoto Yoshimitsu, Yoshitaka Imaizumi, Shinsuke Iida, Atae Utsunomiya, Tetsuo Noda, Hiroyoshi Nishikawa, Ryuzo Ueda, Takashi Ishida

https://doi.org/10.3324/haematol.2021.280352

Apr 7, 2022

Articles

Treatment-free remission in chronic myeloid leukemia patients treated front-line with nilotinib: 10-year follow-up of the GIMEMA CML 0307 study (720 Online Views)

Gabriele Gugliotta, Fausto Castagnetti, Massimo Breccia, Luciano Levato, Tamara Intermesoli, Mariella D'Adda, Marzia Salvucci, Fabio Stagno, Giovanna Rege-Cambrin, Mario Tiribelli, Bruno Martino, Monica Bocchia, Michele Cedrone, Elena Trabacchi, Francesco Cavazzini, Ferdinando Porretto, Federica Sorà, Maria Pina Simula, Francesco Albano, Simona Soverini, Robin Foà, Fabrizio Pane, Michele Cavo, Giuseppe Saglio, Michele Baccarani, Gianantonio Rosti

https://doi.org/10.3324/haematol.2021.280175

Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model (583 Online Views)

Nuria Fabregas Bregolat, Maja Ruetten, Milene Costa da Silva, Mostafa A. Aboouf, Hyrije Ademi, Nadine von Büren, Julia Armbruster, Martina Stirn, Sandro Altamura, Oriana Marques, Josep M. Monné Rodriguez, Victor J. Samillan, Rashim Pal Singh, Ben Wielockx, Martina U. Muckenthaler, Max Gassmann, Markus Thiersch

https://doi.org/10.3324/haematol.2022.280732

The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodies (555 Online Views)

Caroline Vayne, Raghavendra Palankar, Sandra Billy, Stefan Handtke, Thomas Thiele, Charlotte Cordonnier, Claire Pouplard, Andreas Greinacher, Yves Gruel, Jérôme Rollin

https://doi.org/10.3324/haematol.2021.280251

Mar 31, 2022

Articles

Final analysis of the phase 3 non-inferiority COLUMBA study of subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (1249 Online Views)

Saad Z. Usmani, Hareth Nahi, Wojciech Legiec, Sebastian Grosicki, Vladimir Vorobyev, Ivan Spicka, Vania Hungria, Sibirina Korenkova, Nizar J. Bahlis, Max Flogegard, Joan Bladé, Philippe Moreau, Martin Kaiser, Shinsuke Iida, Jacob Laubach, Hila Magen, Michele Cavo, Cyrille Hulin, Darrell White, Valerio De Stefano, Kristen Lantz, Lisa O’Rourke, Christoph Heuck, Maria Delioukina, Xiang Qin, Ivo Nnane, Ming Qi, Maria-Victoria Mateos

https://doi.org/10.3324/haematol.2021.279459

Glycolytic enzyme PFKFB3 determines bone marrow endothelial progenitor cell damage post chemotherapy and irradiation (762 Online Views)

Zhong-Shi Lyu, Shu-Qian Tang, Tong Xing, Yang Zhou, Meng Lv, Hai-Xia Fu, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Hsiang-Ying Lee, Yuan Kong, Xiao-Jun Huang

https://doi.org/10.3324/haematol.2021.279756

Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes (731 Online Views)

Stavroula Anastasopoulou, Rikke Linnemann Nielsen, Bodil Als-Nielsen, Joanna Banerjee, Mats A. Eriksson, Marianne Helenius, Mats M. Heyman, Inga Maria Johannsdottir, Olafur Gisli Jonsson, Stuart MacGregor, Marion K. Mateos, Chelsea Mayoh, Sirje Mikkel, Ida Hed Myrberg, Riitta Niinimäki, Kjeld Schmiegelow, Mervi Taskinen, Goda Vaitkeviciene, Anna Warnqvist, Benjamin Wolthers, Arja Harila-Saari, Susanna Ranta

https://doi.org/10.3324/haematol.2021.280016

Preclinical evaluation and structural optimization of anti-BCMA CAR to target multiple myeloma (963 Online Views)

Ortal Harush, Nathalie Asherie, Shlomit Kfir-Erenfeld, Galit Adler, Tilda Barliya, Miri Assayag, Moshe E. Gatt, Polina Stepensky, Cyrille J. Cohen

https://doi.org/10.3324/haematol.2021.280169

Fc galactosylation of anti-platelet hIgG1 alloantibodies enhance complement activation on platelets (654 Online Views)

Thijs L.J. van Osch, Janita J. Oosterhoff, Arthur E. H. Bentlage, Jan Nouta, Carolien A. M. Koeleman, Dionne M. Geerdes, Juk Yee Mok, Sebastiaan Heidt, Arend Mulder, Wim J. E. van Esch, Rick Kapur, Leendert Porcelijn, C. Ellen van der Schoot, Masja de Haas, Manfred Wuhrer, Jan Voorberg, Gestur Vidarsson

https://doi.org/10.3324/haematol.2021.280493

Mar 24, 2022

Editorials
Article

Autologous stem cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study (1089 Online Views)

Alejandro Martín García-Sancho, Monica Bellei, Miriam López-Parra, Giuseppe Gritti, María Cortés, Silvana Novelli, Carlos Panizo, Luigi Petrucci, Antonio Gutiérrez, Ivan Dlouhy, Mariana Bastos-Oreiro, Juan M. Sancho, María J. Ramírez, José M. Moraleda, Estrella Carrillo, Ana I. Jiménez-Ubieto, Isidro Jarque, Lorella Orsucci, Estefanía García-Torres, Carlos Montalbán, Anna Dodero, Reyes Arranz, Natalia de las Heras, María J. Pascual, Javier López-Jiménez, Michelle Spina, Alessandro Re, Sonia González de Villambrosia, Sabela Bobillo, Massimo Federico, Dolores Caballero

https://doi.org/10.3324/haematol.2021.279426

Mar 17, 2022

Editorials
Article

Clinical relevance of an objective – limit of detection – limit of quantification - based flow cytometry approach for measurable residual disease assessment in acute myeloid leukemia. A post-hoc analysis of the GIMEMA AML1310 trial. (563 Online Views)

Francesco Buccisano, Raffaele Palmieri, Alfonso Piciocchi, Valentina Arena, Luca Maurillo, Maria-Ilaria Del Principe, Giovangiacinto Paterno, Maria-Antonietta Irno-Consalvo, Tiziana Ottone, Mariadomenica Divona, Consuelo Conti, Daniela Fraboni, Serena Lavorgna, William Arcese, Maria Teresa Voso, Adriano Venditti

https://doi.org/10.3324/haematol.2021.279777

Editorials

Articles

Mar 10, 2022

Editorials
Article

The IL32/BAFF axis supports prosurvival dialogs in the lymphoma ecosystem and is disrupted by NIK inhibition (665 Online Views)

Salomé Decombis, Antonin Papin, Céline Bellanger, Clara Sortais, Christelle Dousset, Yannick Le Bris, Thiphanie Riveron, Stéphanie Blandin, Philippe Hulin, Benoit Tessoulin, Mathieu Rouel, Steven Le Gouill, Agnès Moreau-Aubry, Catherine Pellat-Deceunynck, David Chiron

https://doi.org/10.3324/haematol.2021.279800

Feb 24, 2022

Editorials
Article

Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia (985 Online Views)

Amos Tuval, Yardena Brilon, Hadas Azogy, Yoni Moskovitz, Dena Leshkowitz, Tomer M Salame, Mark D Minden, Perry Tal, Varda Rotter, Moshe Oren, Nathali Kaushansky, Liran I Shlush

https://doi.org/10.3324/haematol.2021.280329

Feb 17, 2022

Editorials
Article

The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of acute myeloid leukemias (1086 Online Views)

Rosa Paolillo, Mathias Boulanger, Pierre Gâtel, Ludovic Gabellier, Marion De Toledo, Denis Tempé, Rawan Hallal, Dana Akl, Jérôme Moreaux, Hayeon Baik, Elise Gueret, Christian Recher, Jean-Emmanuel Sarry, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis

https://doi.org/10.3324/haematol.2021.279889

Feb 3, 2022

Editorials
Article

Temsirolimus combined with cyclophosphamide and etoposide for pediatric patients with relapsed/refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium trial (TACL 2014-001) (684 Online Views)

Sarah K. Tasian, Lewis B. Silverman, James A. Whitlock, Richard Sposto, Joseph P. Loftus, Eric S. Schafer, Kirk R. Schultz, Raymond J. Hutchinson, Paul S. Gaynon, Etan Orgel, Caroline M. Bateman, Todd M. Cooper, Theodore W. Laetsch, Maria Luisa Sulis, Yueh-Yun Chi, Jemily Malvar, Alan S. Wayne, Susan R. Rheingold

https://doi.org/10.3324/haematol.2021.279520

Editorials
Article

YTHDF3 modulates hematopoietic stem cells by recognizing RNA m6A modification on Ccnd1 (1237 Online Views)

Xiaofei Zhang, Tingting Cong, Lei Wei, Bixi Zhong, Xiaowo Wang, Jin Sun, Shuxia Wang, Meng Michelle Xu, Ping Zhu, Hong Jiang, Jianwei Wang

https://doi.org/10.3324/haematol.2021.279739

Jan 13, 2022

Editorials
Article

Clinical relevance of proteomic profiling in de novo pediatric acute myeloid leukemia: a Children’s Oncology Group study (932 Online Views)

Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Chenyue W. Hu, Rhonda E. Ries, Andrew Ligeralde, Gaye N. Jenkins, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Amina A. Qutub, Eveline S.J.M. de Bont, Terzah M. Horton, Steven M. Kornblau

https://doi.org/10.3324/haematol.2021.279672

Articles

Oncogenic TYK2P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade (826 Online Views)

Katharina Woess, Sabine Macho-Maschler, Dorette S. van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, Claus Vogl, Anna Koren, Stefan Kubicek, Anna Orlova, Richard Moriggl, Birgit Strobl, Veronika Sexl, Frank N. van Leeuwen, Roland P. Kuiper, Mathias Mueller

https://doi.org/10.3324/haematol.2021.279848

Aug 19, 2021

Errata Corrige

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (2154 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2021.279802

Aug 5, 2021

Articles

Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets (1178 Online Views)

Inga Scheller, Sarah Beck, Vanessa Göb, Carina Gross, Raluca A. I. Neagoe, Katja Aurbach, Markus Bender, David Stegner, Zoltan Nagy, Bernhard Nieswandt

https://doi.org/10.3324/haematol.2021.278537

May 10, 2018

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells (851 Online Views)

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

https://doi.org/10.3324/haematol.2018.189399