Early view

Sep 16, 2021

Articles

Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivo (144 Online Views)

Leo Nicolai, Rainer Kaiser, Raphael Escaig, Marie-Louise Hoffknecht, Afra Anjum, Alexander Leunig, Joachim Pircher, Andreas Ehrlich, Michael Lorenz, Hellen Ishikawa-Ankerhold, William C. Aird, Steffen Massberg, Florian Gaertner

https://doi.org/10.3324/haematol.2021.278896

Letters to the Editor

Targeting Wnt signaling in acute myeloid leukemia stem cells (68 Online Views)

Felice Pepe, Marius Bill, Dimitrios Papaioannou, Malith Karunasiri, Allison Walker, Eric Naumann, Katiri Snyder, Parvathi Ranganathan, Adrienne Dorrance, Ramiro Garzon

https://doi.org/10.3324/haematol.2020.266155

Lower respiratory tract infection with Staphylococcus aureus in sickle-cell adult patients with severe acute chest syndrome - the STAPHACS Study (45 Online Views)

Alexandre Elabbadi, Guillaume Voiriot, Anne Tristan, Aude Gibelin, Charlotte Verdet, Michel Djibré, Aline Santin, Etienne-Marie Jutant, Julien Lopinto, François Vandenesch, François Lionnet, Muriel Fartoukh

https://doi.org/10.3324/haematol.2021.278827

In utero thirdhand smoke exposure modulates platelet function in a sex-dependent manner (43 Online Views)

Hamdy A. Ali, Ahmed B. Alarabi, Zubair A. Karim, Victor Rodriguez, Keziah R. Hernandez, Patricia A. Lozano, Medhat S. El-Halawany, Fatima Z. Alshbool, Fadi T. Khasawneh

https://doi.org/10.3324/haematol.2021.279388

Sep 9, 2021

Articles

Hepcidin regulation in Kenyan children with severe malaria and non-typhoidal Salmonella bacteremia (288 Online Views)

Kelvin M. Abuga, John Muthii Muriuki, Sophie M. Uyoga, Kennedy Mwai, Johnstone Makale, Reagan M. Mogire, Alex W. Macharia, Shebe Mohammed, Esther Muthumbi, Salim Mwarumba, Neema Mturi, Philip Bejon, J. Anthony G. Scott, Manfred Nairz, Thomas N. Williams, Sarah H. Atkinson

https://doi.org/10.3324/haematol.2021.279316

Letters to the Editor

Dose-adjusted EPOCH-rituximab or intensified B-NHL therapy for pediatric primary mediastinal large B-cell lymphoma (124 Online Views)

Fabian Knörr, Martin Zimmermann, Andishe Attarbaschi, Edita Kabíčková, Britta Maecker-Kolhoff, Stephanie Ruf, Ingrid Kühnle, Martin Ebinger, Anne-Kathrin Garthe, Ingrid Simonitsch-Klupp, Ilske Oschlies, Wolfram Klapper, Birgit Burkhardt, Wilhelm Woessmann

https://doi.org/10.3324/haematol.2021.278971

Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter (172 Online Views)

Killian Donovan, Athinoula Meli, Francesca Cendali, Kyung Chan Park, Rebecca Cardigan, Simon Stanworth, Stuart McKechnie, Angelo D’Alessandro, Peter A. Smethurst, Pawel Swietach

https://doi.org/10.3324/haematol.2021.279296

Sep 2, 2021

Letters to the Editor

Diabetes mellitus and risk of plasma cell and lymphoproliferative disorders in 94,579 cases and 368,348 matched controls (134 Online Views)

Urvi A. Shah, Sæmundur Rögnvaldsson, Andriy Derkach, Magnus Björkholm, Ingemar Turesson, Yael David, Malin Hultcrantz, Carlyn Tan, Hani Hassoun, Neha Korde, Alexander Lesokhin, Sham Mailankody, Sigurður Yngvi Kristinsson, C. Ola Landgren

https://doi.org/10.3324/haematol.2021.278772

Platelet activation and modulation in thrombosis with thrombocytopenia syndrome associated with ChAdO×1 nCov-19 vaccine (123 Online Views)

Mariangela Scavone, Bianca Clerici, Simone Birocchi, Tatiana Mencarini, Mariagrazia Calogiuri, Claudia Ghali, Daniele Prati, Silvia Bozzi, Paolo Villa, Marco Cattaneo, Gian Marco Podda

https://doi.org/10.3324/haematol.2021.279345

Case Reports

Aug 26, 2021

Editorials
Article

Refined HLA-DPB1 mismatch with molecular algorithms predicts outcomes in hematopoietic stem cell transplantation (170 Online Views)

Jun Zou, Piyanuch Kongtim, Betül Oran, Vasilis Kosmoliaptsis, Yudith Carmazzi, Junsheng Ma, Liang Li, Gabriela Rondon, Samer Srour, Hannah C. Copley, David Partlow, Stefan O. Ciurea, Uri Greenbaum, Qing Ma, Elizabeth J. Shpall, Richard E. Champlin, Kai Cao

https://doi.org/10.3324/haematol.2021.278993

Editorials
Letter to the Editor

Immune thrombocytopenia following vaccination during the COVID-19 pandemic (248 Online Views)

Philip Young-Ill Choi, Danny Hsu, Huyen Anh Tran, Chee Wee Tan, Anoop Enjeti, Vivien Mun Yee Chen, Beng Hock Chong, Jennifer Curnow, Dominic Pepperell, Robert Bird

https://doi.org/10.3324/haematol.2021.279442

Letters to the Editor

Allogeneic hematopoietic cell transplantation outcomes in patients with Richter’s transformation (100 Online Views)

Haesook T. Kim, Peter O. Baker, Erin Parry, Matthew Davids, Edwin P. Alyea, Vincent T. Ho, Corey Cutler, John Koreth, Mahasweta Gooptu, Rizwan Romee, Sarah Nikiforow, Joseph H. Antin, Jerome Ritz, Robert J. Soiffer, Catherine J. Wu, Jennifer R. Brown

https://doi.org/10.3324/haematol.2021.279033

Aug 19, 2021

Review Articles

Articles

Establishment of a Bernard-Soulier syndrome model in zebrafish (248 Online Views)

Qing Lin, Riyang Zhou, Panpan Meng, Liangliang Wu, Lian Yang, Wenyu Liu, Jiaye Wu, Yuhuan Cheng, Linjuan Shi, Yiyue Zhang

https://doi.org/10.3324/haematol.2021.278893

Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study (187 Online Views)

Lale Kostakoglu, Federico Mattiello, Maurizio Martelli, Laurie H. Sehn, David Belada, Chiara Ghiggi, Neil Chua, Eva González-Barca, Xiaonan Hong, Antonio Pinto, Yuankai Shi, Yoichi Tatsumi, Christopher Bolen, Andrea Knapp, Gila Sellam, Tina Nielsen, Deniz Sahin, Umberto Vitolo, Marek Trněný

https://doi.org/10.3324/haematol.2021.278663

Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease (334 Online Views)

Eileen Haring, Geoffroy Andrieux, Franziska M. Uhl, Máté Krausz, Michele Proietti, Barbara Sauer, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Annette Schmitt-Graeff, Justus Duyster, Natalie Köhler, Bodo Grimbacher, Melanie Boerries, Konrad Aumann, Robert Zeiser, Petya Apostolova

https://doi.org/10.3324/haematol.2021.278387

Letters to the Editor

Melphalan dose intensity for autologous stem cell transplantation in multiple myeloma (80 Online Views)

Samer A. Srour, Denái R. Milton, Qaiser Bashir, Yago Nieto, Neeraj Saini, May Daher, Jeremy Ramdial, Jin Im, Chitra Hosing, Ruby Delgado, Elisabet Manasanch, Hans C. Lee, Sheeba Thomas, Greg Kaufman, Krina Patel, Uday Popat, Donna Weber, Robert Orlowski, Elizabeth Shpall, Richard E. Champlin, Muzaffar H. Qazilbash

https://doi.org/10.3324/haematol.2021.279179

Biallelic mutations in the SARS2 gene presenting as congenital sideroblastic anemia (161 Online Views)

Elia Colin, Geneviève Courtois, Chantal Brouzes, Juliette Pulman, Marion Rabant, Agnès Rötig, Hélène Taffin, Mathilde Lion-Lambert, Sylvie Fabrega, Lydie Da Costa, Mariane De Montalembert, Rémi Salomon, Olivier Hermine, Lucile Couronné

https://doi.org/10.3324/haematol.2021.279138

Errata Corrige

Long-term outcomes from the phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (615 Online Views)

Johannes Duell, Kami J. Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2021.279802

Aug 12, 2021

Editorials
Case Report

Immune-mediated thrombotic thrombocytopenic purpura following Pfizer-BioNTech COVID-19 vaccine (146 Online Views)

Gaetano Giuffrida, Annalisa Condorelli, Mary Ann Di Giorgio, Uros Markovic, Roberta Sciortino, Daniela Nicolosi, Francesco Di Raimondo

https://doi.org/10.3324/haematol.2021.279535

Articles

One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors (198 Online Views)

Dietger Niederwieser, Helen Baldomero, Nosa Bazuaye, Caitrin Bupp, Naeem Chaudhri, Selim Corbacioglu, Alaa Elhaddad, Cristóbal Frutos, Sebastian Galeano, Nada Hamad, Amir Ali Hamidieh, Shahrukh Hashmi, Aloysius Ho, Mary M. Horowitz, Minako Iida, Gregorio Jaimovich, Amado Karduss, Yoshihisa Kodera, Nicolaus Kröger, Regis Péffault de Latour, Jong Wook Lee, Juliana Martínez-Rolón, Marcelo C. Pasquini, Jakob Passweg, Kristjan Paulson, Adriana Seber, John A. Snowden, Alok Srivastava, Jeff Szer, Daniel Weisdorf, Nina Worel, Mickey B.C. Koh, Mahmoud Aljurf, Hildegard Greinix, Yoshiko Atsuta, Wael Saber

https://doi.org/10.3324/haematol.2021.279189

Whole-genome profiling of primary cutaneous anaplastic large cell lymphoma (269 Online Views)

Armando N. Bastidas Torres, Rutger C. Melchers, Liana van Grieken, Jacoba J. Out-Luiting, Hailiang Mei, Cedrick Agaser, Thomas B. Kuipers, Koen D. Quint, Rein Willemze, Maarten H. Vermeer, Cornelis P. Tensen

https://doi.org/10.3324/haematol.2020.263251

Renal function and clinical outcome of patients with cancer-associated venous thromboembolism randomized to receive apixaban or dalteparin. Results from the Caravaggio trial (404 Online Views)

Cecilia Becattini, Rupert Bauersachs, Giorgio Maraziti, Laurent Bertoletti, Alexander Cohen, Jean M. Connors, Dario Manfellotto, Antonio Sanchez, Benjamin Brenner, Giancarlo Agnelli

https://doi.org/10.3324/haematol.2021.279072

Letters to the Editor

Predicting risk of progression in relapsed multiple myeloma using traditional risk models, focal lesion assessment with PET-CT and minimal residual disease status (62 Online Views)

David Baker, Milan Bimali, Luis Carrillo, Archana Sachedina, Daisy Alapat, Md Shadiqul Hoque, Mathew Kottarathara, Richa Parikh, Amani Erra, Angel A. Mitma, Pankaj Mathur, Yetunde Ogunsesan, Lakshmi Yarlagadda, Sravani Gundarlapalli, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Guido Tricot, Carolina Schinke

https://doi.org/10.3324/haematol.2021.278779

Case Reports

Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels (175 Online Views)

Jonathan Douxfils, Caroline Vayne, Claire Pouplard, Thomas Lecompte, Julien Favresse, Florence Potier, Emy Gasser, Valérie Mathieux, Jean-Michel Dogné, Yves Gruel, Jérôme Rollin, François Mullier

https://doi.org/10.3324/haematol.2021.279509

Aug 5, 2021

Editorials
Article

Characteristics and outcome of patients with core binding factor acute myeloid leukemia and FLT3-ITD: results from an international collaborative study (267 Online Views)

Sabine Kayser, Michael Kramer, David Martínez-Cuadrón, Justin Grenet, Klaus H. Metzeler, Zuzana Sustkova, Marlise R. Luskin, Andrew M. Brunner, Michelle A. Elliott, Cristina Gil, Sandra Casal Marini, Zdeněk Ráčil, Petr Cetkovsky, Jan Novak, Alexander E. Perl, Uwe Platzbecker, Friedrich Stölzel, Anthony D. Ho, Christian Thiede, Richard M. Stone, Christoph Röllig, Pau Montesinos, Richard F. Schlenk, Mark J. Levis

https://doi.org/10.3324/haematol.2021.278645

Editorials
Letter to the Editor

Dual pyroptotic biomarkers predict erythroid response in lower risk non-del(5q) myelodysplastic syndromes treated with lenalidomide and recombinant erythropoietin (247 Online Views)

Chen Wang, Kathy L. McGraw, Amy F. McLemore, Rami Komrokji, Ashley A. Basiorka, Najla Al Ali, Jeffrey E. Lancet, Eric Padron, Olivier Kosmider, Michaela Fontenay, Pierre Fenaux, Alan F. List, David A. Sallman

https://doi.org/10.3324/haematol.2021.278855

Editorials
Letter to the Editor

Daratumumab, an original approach for treating multi-refractory autoimmune cytopenia (216 Online Views)

Etienne Crickx, Sylvain Audia, Ailsa Robbins, David Boutboul, Thibault Comont, Morgane Cheminant, Eric Oksenhendler, Bertrand Godeau, Marc Michel, Matthieu Mahevas

https://doi.org/10.3324/haematol.2021.279232

Articles

Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets (319 Online Views)

Inga Scheller, Sarah Beck, Vanessa Göb, Carina Gross, Raluca A. I. Neagoe, Katja Aurbach, Markus Bender, David Stegner, Zoltan Nagy, Bernhard Nieswandt

https://doi.org/10.3324/haematol.2021.278537

Clofarabine increases the eradication of minimal residual disease of primary Bprecursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome (186 Online Views)

Gabriele Escherich, Udo zur Stadt, Arndt Borkhardt, Dagmar Dilloo, Jörg Faber, Tobias Feuchtinger, Thomas Imschweiler, Norbert Jorch, Arnulf Pekrun, Irene Schmid, Franziska Schramm, Michael Spohn, Martin Zimmermann, Martin A Horstmann

https://doi.org/10.3324/haematol.2021.279357

Letters to the Editor

Jul 29, 2021

Editorials

Editorials
Article

Humoral serologic response to the BNT162b2 vaccine is abrogated in lymphoma patients within the first 12 months following treatment with anti-CD2O antibodies (402 Online Views)

Ronit Gurion, Uri Rozovski, Gilad Itchaki, Anat Gafter-Gvili, Chiya Leibovitch, Pia Raanani, Haim Ben-Zvi, Moran Szwarcwort, Mor Taylor-Abigadol, Eldad J. Dann, Nurit Horesh, Tsofia Inbar, Inna Tzoran, Noa Lavi, Riva Fineman, Shimrit Ringelstein-Harlev, Netanel A. Horowitz

https://doi.org/10.3324/haematol.2021.279216
Article

Safety and efficacy of BNT162b mRNA Covid19 Vaccine in patients with chronic lymphocytic leukemia (1167 Online Views)

Ohad Benjamini, Lior Rokach, Gilad Itchaki, Andrei Braester, Lev Shvidel, Neta Goldschmidt, Shirley Shapira, Najib Dally, Abraham Avigdor, Galia Rahav, Yaniv Lustig, Shirley Shapiro Ben David, Riva Fineman, Alona Paz, Osnat Bairey, Aaron Polliack, Ilana Levy, Tamar Tadmor

https://doi.org/10.3324/haematol.2021.279196

Review Articles

Articles

UBA6 and NDFIP1 regulate the degradation of ferroportin (320 Online Views)

Lisa Traeger, Steffen B. Wiegand, Andrew J. Sauer, Benjamin H.P. Corman, Kathryn M. Peneyra, Florian Wunderer, Anna Fischbach, Aranya Bagchi, Rajeev Malhotra, Warren M. Zapol, Donald B. Bloch

https://doi.org/10.3324/haematol.2021.278530

Phase I/II clinical trial of temsirolimus and lenalidomide in patients with relapsed and refractory lymphomas (504 Online Views)

Ajay Major, Justin Kline, Theodore G. Karrison, Paul A. S. Fishkin, Amy S. Kimball, Adam M. Petrich, Sreenivasa Nattam, Krishna Rao, Bethany G. Sleckman, Kenneth Cohen, Koen van Besien, Aaron P. Rapoport, Sonali M. Smith

https://doi.org/10.3324/haematol.2021.278853

Letters to the Editor

Allogeneic hematopoietic stem cell transplantation from nonsibling 10/10 HLA-matched related donors: a single-center experience (243 Online Views)

Yaoyao Shen, Jiaqian Qi, Jia Chen, Yang Xu, Feng Chen, Xiao Ma, Miao Miao, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Depei Wu, Ying Wang

https://doi.org/10.3324/haematol.2021.278933

Case Reports

Dominance of an UBA1 mutant clone over a CALR mutant clone: from essential thrombocytemia to VEXAS. (287 Online Views)

Mehdi Hage-Sleiman, Sophie Lalevée, Hélène Guermouche, Fabrizia Favale, Michael Chaquin, Maxime Battistella, Jean-David Bouaziz, Martine Bagot, François Delhommeau, Florence Cordoliani, Pierre Hirsch

https://doi.org/10.3324/haematol.2021.279418

Jul 22, 2021

Articles

Dose-Adjusted Epoch and Rituximab for the treatment of double expressor and double hit diffuse large B-cell lymphoma: impact of TP53 mutations on clinical outcome (503 Online Views)

Anna Dodero, Anna Guidetti, Fabrizio Marino, Alessandra Tucci, Francesco Barretta, Alessandro Re, Monica Balzarotti, Cristiana Carniti, Chiara Monfrini, Annalisa Chiappella, Antonello Cabras, Fabio Facchetti, Martina Pennisi, Daoud Rahal, Valentina Monti, Liliana Devizzi, Rosalba Miceli, Federica Cocito, Lucia Farina, Francesca Ricci, Giuseppe Rossi, Carmelo Carlo-Stella, Paolo Corradini

https://doi.org/10.3324/haematol.2021.278638

Prephase rituximab/prednisone therapy and aging-related, pro-inflammatory cytokine milieu in older, vulnerable patients with newly diagnosed diffuse large B-cell lymphoma (375 Online Views)

Richard J. Lin, Colette N. Owens, Esther Drill, Augustine Iannotta, Mayan Oliveros, Dylan L. Schick, Ariela Noy, John F. Gerecitano, Pamela R. Drullinsky, Philip C. Caron, Anita Kumar, Matthew J. Matasar, Craig Moskowitz, Beatriz Korc-Grodzicki, Andrew D. Zelenetz, Gilles A. Salles, Paul A. Hamlin

https://doi.org/10.3324/haematol.2021.278719

Complement dysregulation is associated with severe COVID-19 illness (658 Online Views)

Jia Yu, Gloria F. Gerber, Hang Chen, Xuan Yuan, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky

https://doi.org/10.3324/haematol.2021.279155

Jul 15, 2021

Review Articles

2021 European Myeloma Network review and consensus statement on smoldering multiple myeloma: how to distinguish (and manage) Dr. Jekyll and Mr. Hyde (844 Online Views)

Pellegrino Musto, Monika Engelhardt, Jo Caers, Niccolo’ Bolli, Martin Kaiser, Niels van de Donk, Evangelos Terpos, Annemiek Broijl, Carlos Fernández de Larrea, Francesca Gay, Hartmut Goldschmidt, Roman Hajek, Annette Juul Vangsted, Elena Zamagni, Sonja Zweegman, Michele Cavo, Meletios Dimopoulos, Hermann Einsele, Heinz Ludwig, Giovanni Barosi, Mario Boccadoro, Maria-Victoria Mateos, Pieter Sonneveld, Jesus San Miguel

https://doi.org/10.3324/haematol.2021.278519

Articles

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia (273 Online Views)

Dimitrios Papaioannou, Hatice G. Ozer, Deedra Nicolet, Amog P. Urs, Tobias Herold, Krzysztof Mrózek, Aarif M.N. Batcha, Klaus H. Metzeler, Ayse S. Yilmaz, Stefano Volinia, Marius Bill, Jessica Kohlschmidt, Maciej Pietrzak, Christopher J. Walker, Andrew J. Carroll, Jan Braess, Bayard L. Powell, Ann-Kathrin Eisfeld, Geoffrey L. Uy, Eunice S. Wang, Jonathan E. Kolitz, Richard M. Stone, Wolfgang Hiddemann, John C. Byrd, Clara D. Bloomfield, Ramiro Garzon

https://doi.org/10.3324/haematol.2021.266643

Letters to the Editor

Case Reports

Massive cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (1136 Online Views)

Sara Bonato, Andrea Artoni, Anna Lecchi, Ghil Schwarz, Silvia La Marca, Lidia Padovan, Marigrazia Clerici, Chiara Guadino, Giacomo Pietro Comi, Armando Tripodi, Flora Peyvandi

https://doi.org/10.3324/haematol.2021.279246

Intracerebral hemorrhage associated with vaccine-induced thrombotic thrombocytopenia following ChAdOx1 nCOVID-19 vaccine in a pregnant woman (892 Online Views)

Daniela P. Mendes-de-Almeida, Remy Martins-Gonçalves, Renata Morato-Santos, Gustavo Adolpho C. de Carvalho, Silas A. Martins, Lohanna Palhinha, Vanessa Sandim, Elyzabeth Avvad-Portari, Fernando A. Bozza, Robson Q. Monteiro, Patrícia T. Bozza, Pedro Kurtz

https://doi.org/10.3324/haematol.2021.279407

Jul 8, 2021

Articles

Toxicity and efficacy of chimeric antigen receptor T-cell in patients with diffuse large B cell lymphoma above the age of 70 years compare to younger patients – a matched control multi-center cohort study (763 Online Views)

Ron Ram, Sigal Grisariu, Liat Shargian-Alon, Odelia Amit, Yaeli Bar-On, Polina Stepensky, Moshe Yeshurun, Batia Avni, David Hagin, Chava Perry, Ronit Gurion, Nadav Sarid, Yair Herishanu, Ronit Gold, Chen Glait-Santar, Sigi Kay, Irit Avivi

https://doi.org/10.3324/haematol.2021.278288

Germline GATA2 variant disrupting endothelial eNOS cell function and angiogenesis can be restored by c-Jun/AP-1 upregulation (345 Online Views)

Giulio Purgatorio, Elisa Piselli, Giuseppe Guglielmini, Emanuela Falcinelli, Loredana Bury, Valeria Di Battista, Fabrizia Pellanera, Francesca Milano, Caterina Matteucci, Cristina Mecucci, Paolo Gresele

https://doi.org/10.3324/haematol.2021.278450

Letters to the Editor

Single-cell profiling reveals the dynamics of cytomegalovirusspecific T-cells in haploidentical hematopoietic stem cell transplantation (294 Online Views)

Jasper J. P. van Beek, Simone Puccio, Alessandra Roberto, Federica De Paoli, Giulia Graziano, Elisa Salviato, Giorgia Alvisi, Veronica Zanon, Alice Scarpa, Elisa Zaghi, Michela Calvi, Clara Di Vito, Rossana Mineri, Barbara Sarina, Chiara De Philippis, Armando Santoro, Jacopo Mariotti, Stefania Bramanti, Francesco Ferrari, Luca Castagna, Domenico Mavilio, Enrico Lugli

https://doi.org/10.3324/haematol.2020.276352

Acalabrutinib for treatment of diffuse large B-cell lymphoma: results from a phase 1b study (482 Online Views)

Paolo Strati, Sven de Vos, Jia Ruan, Kami J. Maddocks, Christopher R. Flowers, Simon Rule, Priti Patel, Yan Xu, Helen Wei, Melanie M. Frigault, Roser Calvo, Martin J.S. Dyer

https://doi.org/10.3324/haematol.2021.278654

Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia (240 Online Views)

Jessica Leonard, Joelle SJ Wolf, Michelle Degnin, Christopher A. Eide, Dorian LaTocha, Kyle Lenz, Beth Wilmot, Charles G. Mullighan, Mignon Loh, Stephen P Hunger, Brian J Druker, Marc M Loriaux, Jeffrey W Tyner, Bill H Chang

https://doi.org/10.3324/haematol.2021.278692

The RUNX1 Database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy (735 Online Views)

Claire C. Homan, Sarah L. King-Smith, David M. Lawrence, Peer Arts, Jinghua Feng, James Andrews, Mark Armstrong, Thuong Ha, Julia Dobbins, Michael W. Drazer, Kai Yu, Csaba Bödör, Alan Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Jude Fitzgibbon, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V. Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Rienhoff, Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Velloso, Benedict Yan, Paul Liu, Lucy A. Godley, Andreas W. Schreiber, Christopher N. Hahn, Hamish S. Scott, Anna L. Brown

https://doi.org/10.3324/haematol.2021.278762

Sex-dependent membranopathy in stored human red blood cells (229 Online Views)

Ewa Szczesny-Malysiak, Tasnim Mohaissen, Katarzyna Bulat, Magdalena Kaczmarska, Aleksandra Wajda, Katarzyna M. Marzec

https://doi.org/10.3324/haematol.2021.278895

Case Reports

Successful pregnancies after transplantation of ovarian tissue retrieved and cryopreserved at time of childhood acute lymphoblastic leukemia – A case report (456 Online Views)

Kenny A. Rodriguez-Wallberg, Milan Milenkovic, Kiriaki Papaikonomou, Victoria Keros, Britt Gustafsson, Fotios Sergouniotis, Ida Wikander, Ronak Perot, Birgit Borgström, Per Ljungman, Gisela Barbany

https://doi.org/10.3324/haematol.2021.278828

Jul 1, 2021

Editorials
Article

Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy (372 Online Views)

Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling

https://doi.org/10.3324/haematol.2021.278411

Review Articles

Articles

A homozygous duplication of the FGG exon 8-intron 8 junction causes congenital afibrinogenemia. Lessons learned from the study of a large consanguineous Turkish family (272 Online Views)

Michel Guipponi, Frédéric Masclaux, Frédérique Sloan-Béna, Corinne Di Sanza, Namik Özbek, Flora Peyvandi, Marzia Menegatti, Alessandro Casini, Baris Malbora, Marguerite Neerman-Arbez

https://doi.org/10.3324/haematol.2021.278945

Letters to the Editor

IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kδ inhibitor idelalisib (509 Online Views)

Veronika Sandova, Gabriela Mladonicka Pavlasova, Vaclav Seda, Katerina Amruz Cerna, Sonali Sharma, Veronika Palusova, Yvona Brychtova, Sarka Pospisilova, Stacey M. Fernandes, Anna Panovska, Michael Doubek, Matthew S. Davids, Jennifer R. Brown, Jiri Mayer, Marek Mraz

https://doi.org/10.3324/haematol.2021.278644

Therapeutic potential of ruxolitinib and ponatinib in patients with EPOR-rearranged Philadelphia chromosome-like acute lymphoblastic leukemia (350 Online Views)

Lisa M Niswander, Joseph P Loftus, Élodie Lainey, Aurélie Caye-Eude, Morgane Pondrom, David A Hottman, Ilaria Iacobucci, Charles G Mullighan, Nitin Jain, Marina Konopleva, Hélène Cavé, André Baruchel, Pierre S Rohrlich, Sarah K Tasian

https://doi.org/10.3324/haematol.2021.278697

A novel classification of hematologic conditions in patients with Fanconi anemia (343 Online Views)

Yvonne Lisa Behrens, Gudrun Göhring, Randa Bawadi, Sümeyye Cöktü, Christina Reimer, Beatrice Hoffmann, Birte Sänger, Simon Käfer, Felicitas Thol, Miriam Erlacher, Charlotte M. Niemeyer, Irith Baumann, Reinhard Kalb, Detlev Schindler, Christian Peter Kratz

https://doi.org/10.3324/haematol.2021.279332

Jun 24, 2021

Articles

Improved outcome of patients with graft-versus-host disease after allogeneic hematopoietic cell transplantation for hematologic malignancies over time: an EBMT mega-file study (397 Online Views)

Hildegard T. Greinix, Dirk-Jan Eikema, Linda Koster, Olaf Penack, Ibrahim Yakoub-Agha, Silvia Montoto, Christian Chabannon, Jan Styczynski, Arnon Nagler, Marie Robin, Stephen Robinson, Yves Chalandon, Malgorzata Mikulska, Stefan Schönland, Zinaida Peric, Annalisa Ruggeri, Francesco Lanza, Liesbeth C. de Wreede, Mohamad Mohty, Grzegorz W. Basak, Nicolaus Kröger

https://doi.org/10.3324/haematol.2020.265769

Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B cell lymphoma (491 Online Views)

Sara Napoli, Luciano Cascione, Andrea Rinaldi, Filippo Spriano, Francesca Guidetti, Fangwen Zhang, Maria Teresa Cacciapuoti, Afua Adjeiwaa Mensah, Giulio Sartori, Nicolas Munz, Mattia Forcato, Silvio Bicciato, Annalisa Chiappella, Paola Ghione, Olivier Elemento, Leandro Cerchietti, Giorgio Inghirami, Francesco Bertoni

https://doi.org/10.3324/haematol.2020.267096

Older patients (aged ≥60 years) with previously untreated advanced-stage classical Hodgkin lymphoma: a detailed analysis from the phase III ECHELON-1 study (624 Online Views)

Andrew M. Evens, Joseph M. Connors, Anas Younes, Stephen M. Ansell, Won Seog Kim, John Radford, Tatyana Feldman, Joseph Tuscano, Kerry J. Savage, Yasuhiro Oki, Andrew Grigg, Christopher Pocock, Monika Dlugosz-Danecka, Keenan Fenton, Andres Forero-Torres, Rachael Liu, Hina Jolin, Ashish Gautam, Andrea Gallamini

https://doi.org/10.3324/haematol.2021.278438

Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas (530 Online Views)

Jing Gao, Michelle Y. Wang, Yuan Ren, Tint Lwin, Tao Li, Joy C Yan, Eduardo M. Sotomayor, Derek R Duckett, Bijal D. Shah, Kenneth H. Shain, Xiaohong Zhao, Jianguo Tao

https://doi.org/10.3324/haematol.2021.278743

Natural history of Waldenström macroglobulinemia following acquired resistance to ibrutinib monotherapy (400 Online Views)

Joshua N. Gustine, Shayna Sarosiek, Catherine A. Flynn, Kirsten Meid, Carly Leventoff, Timothy White, Maria Luisa Guerrera, Lian Xu, Amanda Kofides, Nicholas Tsakmaklis, Manit Munshi, Maria Demos, Christopher J. Patterson, Xia Liu, Guang Yang, Zachary R. Hunter, Andrew R. Branagan, Steven P. Treon, Jorge J. Castillo

https://doi.org/10.3324/haematol.2021.279112

Jun 17, 2021

Editorials
Article

Fusion gene detection by RNA sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements (471 Online Views)

Paul Kerbs, Sebastian Vosberg, Stefan Krebs, Alexander Graf, Helmut Blum, Anja Swoboda, Aarif M. N. Batcha, Ulrich Mansmann, Dirk Metzler, Caroline A. Heckman, Tobias Herold, Philipp A. Greif

https://doi.org/10.3324/haematol.2021.278436

Editorials
Article

Efficacy and safety assessment of prolonged maintenance with subcutaneous rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: results of the Phase III MabCute study (414 Online Views)

Simon Rule, Wolney Gois Barreto, Javier Briones, Angelo M. Carella, Olivier Casasnovas, Chris Pocock, Clemens-Martin Wendtner, Francesco Zaja, Susan Robson, Lachlan MacGregor, Roger R. Tschopp, Sonja Nick, Martin Dreyling

https://doi.org/10.3324/haematol.2020.274803

Editorials
Article

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells (268 Online Views)

Orsola di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, John S. Welch

https://doi.org/10.3324/haematol.2021.278603

Articles

The GPIbα intracellular tail – role in transducing VWF- and collagen/GPVI-mediated signaling (335 Online Views)

Adela Constantinescu-Bercu, Yuxiao A. Wang, Kevin J. Woollard, Pierre Mangin, Karen Vanhoorelbeke, James T.B. Crawley, Isabelle I. Salles-Crawley

https://doi.org/10.3324/haematol.2020.278242

Jun 10, 2021

Articles

Inhibitors of A Disintegrin and Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect (430 Online Views)

Roberta Pece, Sara Tavella, Delfina Costa, Serena Varesano, Caterina Camodeca, Doretta Cuffaro, Elisa Nuti, Armando Rossello, Massimo Alfano, Cristina D’Arrigo, Denise Galante, Jean-Louis Ravetti, Marco Gobbi, Francesca Tosetti, Alessandro Poggi, Maria Raffaella Zocchi

https://doi.org/10.3324/haematol.2021.278469

Letters to the Editor

A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies (261 Online Views)

David H. Vandorpe, Boris E. Shmukler, Yann Ilboudo, Swati Bhasin, Beena Thomas, Alicia Rivera, Jay G. Wohlgemuth, Jeffrey S. Dlott, L. Michael Snyder, Colin Sieff, Manoj Bhasin, Guillaume Lettre, Carlo Brugnara, Seth L. Alper

https://doi.org/10.3324/haematol.2021.278770

Jun 3, 2021

Articles

The complex karyotype landscape in chronic lymphocytic leukemia allows to refine the risk of Richter syndrome transformation (470 Online Views)

Andrea Visentin, Laura Bonaldi, Gian Matteo Rigolin, Francesca Romana Mauro, Annalisa Martines, Federica Frezzato, Stefano Pravato, Leila Romano Gargarella, Maria Antonella Bardi, Maurizio Cavallari, Eleonora Volta, Francesco Cavazzini, Mauro Nanni, Monica Facco, Francesco Piazza, Anna Guarini, Robin Foà, Gianpietro Semenzato, Antonio Cuneo, Livio Trentin

https://doi.org/10.3324/haematol.2021.278304

IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load (352 Online Views)

Dianna Hussmann, Anna Starnawska, Louise Kristensen, Iben Daugaard, Astrid Thomsen, Tina E. Kjeldsen, Christine Søholm Hansen, Jonas Bybjerg-Grauholm, Karina Dalsgaard Johansen, Maja Ludvigsen, Thomas Kristensen, Thomas Stauffer Larsen, Michael Boe Møller, Charlotte Guldborg Nyvold, Lise Lotte Hansen, Tomasz K. Wojdacz

https://doi.org/10.3324/haematol.2021.278477

Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome (606 Online Views)

Ayala Tovy, Carina Rosas, Amos S. Gaikwad, Geraldo Medrano, Linda Zhang, Jaime M. Reyes, Yung-Hsin Huang, Tastuhiko Arakawa, Kristen Kurtz, Shannon E. Conneely, Anna G. Guzman, Rogelio Aguilar, Anne Gao, Chun-Wei Chen, Jean J. Kim, Melissa T. Carter, Amaia Lasa-Aranzasti, Irene Valenzuela, Lionel Van Maldergem, Lorenzo Brunetti, M. John Hicks, Andrea N. Marcogliese, Margaret A. Goodell, Rachel E. Rau

https://doi.org/10.3324/haematol.2021.278990

Letters to the Editor

Chromosome 1q21 abnormalities refine outcome prediction in patients with multiple myeloma – a meta-analysis of 2,596 trial patients (679 Online Views)

Niels Weinhold, Hans J. Salwender, David A. Cairns, Marc S. Raab, George Waldron, Igor W. Blau, Uta Bertsch, Thomas Hielscher, Gareth J. Morgan, Anna Jauch, Faith E. Davies, Mathias Hänel, Gordon Cook, Christoph Scheid, Richard Houlston, Hartmut Goldschmidt, Graham Jackson, Martin F. Kaiser

https://doi.org/10.3324/haematol.2021.278888

May 27, 2021

Editorials
Article

Increments in DNA-thioguanine level during thiopurine enhanced maintenance therapy of acute lymphoblastic leukemia (380 Online Views)

Rikke Hebo Larsen, Cecilie Utke Rank, Kathrine Grell, Lisbeth Nørgaard Møller, Ulrik Malthe Overgaard, Peter Kampmann, Jacob Nersting, Matilda Degn, Stine Nygaard Nielsen, Helle Holst, Birgitte Klug Albertsen, Peder Skov Wehner, Michael Thude Callesen, Jukka Kanerva, Thomas Leth Frandsen, Bodil Als-Nielsen, Lisa Lyngsie Hjalgrim, Kjeld Schmiegelow

https://doi.org/10.3324/haematol.2020.278166

Editorials
Article

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study (492 Online Views)

Sabine Kayser, Richard F. Schlenk, Delphine Lebon, Martin Carre, Katharina S. Götze, Friedrich Stölzel, Ana Berceanu, Kerstin Schäfer-Eckart, Pierre Peterlin, Yosr Hicheri, Ramy Rahme, Emmanuel Raffoux, Fatiha Chermat, Stefan W. Krause, Walter E. Aulitzky, Sophie Rigaudeau, Richard Noppeney, Celine Berthon, Martin Görner, Edgar Jost, Philippe Carassou, Ulrich Keller, Corentin Orvain, Thorsten Braun, Colombe Saillard, Ali Arar, Volker Kunzmann, Mathieu Wemeau, Maike de Wit, Dirk Niemann, Caroline Bonmati, Carsten Schwänen, Julie Abraham, Ahmad Aljijakli, Stephanie Haiat, Alwin Krämer, Albrecht Reichle, Martina Gnadler, Christophe Willekens, Karsten Spiekermann, Wolfgang Hiddemann, Carsten Müller-Tidow, Christian Thiede, Christoph Röllig, Hubert Serve, Martin Bornhäuser, Claudia D. Baldus, Eva Lengfelder, Pierre Fenaux, Uwe Platzbecker, Lionel Adès

https://doi.org/10.3324/haematol.2021.278722

Editorials
Article

A Pin1/PML/P53 axis activated by retinoic acid in NPM-1c-acute myeloid leukemia (356 Online Views)

Rita Hleihel, Hiba El Hajj, Hsin-Chieh Wu, Caroline Berthier, Hong-Hu Zhu, Radwan Massoud, Zaher Chakhachiro, Marwan El Sabban; Hugues de The; Ali Bazarbachi

https://doi.org/10.3324/haematol.2020.274878

Editorials
Letter to the Editor

Cluster of differentiation 33 single nucleotide polymorphism rs12459419 is a predictive factor in patients with nucleophosmin1 mutated acute myeloid leukemia receiving gemtuzumab ozogamicin (367 Online Views)

Katrin Teich, Julia Krzykalla, Silke Kapp-Schwoerer, Verena I. Gaidzik, Richard F. Schlenk, Peter Paschka, Daniela Weber, Walter Fiedler, Michael W.M. Kühn, Thomas Schroeder, Karin Mayer, Michael Lübbert, Dhanya Ramachandran, Axel Benner, Arnold Ganser, Hartmut Döhner, Michael Heuser, Konstanze Döhner, Felicitas Thol

https://doi.org/10.3324/haematol.2021.278894

Letters to the Editor

Inclusion of a shRNA targeting BCL11A into a β-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin (495 Online Views)

Silvia Pires Lourenco, Danuta Jarocha; Valentina Ghiaccio, Amaliris Guerra, Osheiza Abdulmalik, Ping La, Alexandra Zezulin, Kim Smith-Whitley, Janet L. Kwiatkowski, Virginia Guzikowski, Yukio Nakamura, Tobias Raabe, Laura Breda, Stefano Rivella

https://doi.org/10.3324/haematol.2020.276634

May 13, 2021

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Article

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality (481 Online Views)

Aaron Issaian, Ariel Hay, Monika Dzieciatkowska, Domenico Roberti, Silverio Perrotta, Zsuzsanna Darula, Jasmina Redzic, Micheal P. Busch, Grier P. Page, Stephen C. Rogers, Allan Doctor, Kirk C. Hansen, Elan Z. Eisenmesser, James C. Zimring, Angelo D’Alessandro

https://doi.org/10.3324/haematol.2020.278252

Letters to the Editor

Low incidence of COVID-19 severe complications in a large cohort of children with sickle cell disease: a protective role for basal interferon-1 activation? (435 Online Views)

Valentine Brousse, Laurent Holvoet, Rémi Pescarmona, Sebastien Viel, Magali Perret, Benoit Visseaux, Valentine Marie Ferre, Ghislaine Ithier, Caroline Le Van Kim, Malika Benkerrou, Florence Missud, Berengere Koehl

https://doi.org/10.3324/haematol.2021.278573

May 6, 2021

Editorials
Article

MAP-kinase and JAK-STAT pathways dysregulation in plasmablastic lymphoma (796 Online Views)

Joan Enric Ramis-Zaldivar, Blanca Gonzalez-Farre, Alina Nicolae, Svetlana Pack, Guillem Clot, Ferran Nadeu, Anja Mottok, Heike Horn, Joo Y Song, Kai Fu, George Wright, Randy D. Gascoyne, Wing C. Chan, David W. Scott, Andrew L. Feldman, Alexandra Valera, Anna Enjuanes, Rita M. Braziel, Erlend B. Smeland, Louis M. Staudt, Andreas Rosenwald, Lisa M. Rimsza, German Ott, Elaine S Jaffe, Itziar Salaverria, Elias Campo

https://doi.org/10.3324/haematol.2020.271957

Articles

IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation (684 Online Views)

Pablo Peña-Martínez, Ramprasad Ramakrishnan, Carl Högberg, Caroline Jansson, David Gisselsson Nord, Marcus Järås

https://doi.org/10.3324/haematol.2020.270421

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis (707 Online Views)

Yago Nieto, Stephen Gruschkus, Benigno C Valdez, Roy B Jones, Paolo Anderlini, Chitra Hosing, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Neeraj Saini, Samer Srour, Katayoun Rezvani, Jeremy Ramdial, Melissa Barnett, Alison Gulbis, Terri Lynn Shigle, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Simrit Parmar, Raphael Steiner, Bouthaina Dabaja, Chelsea Pinnix, Jillian Gunther, Branko Cuglievan, Kris Mahadeo, Sajad Khazal, Hubert Chuang, Richard Champlin, Elizabeth J Shpall, Borje S Andersson

https://doi.org/10.3324/haematol.2021.278311

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome (541 Online Views)

Katia Todoerti, Domenica Ronchetti, Vanessa Favasuli, Francesco Maura, Fortunato Morabito, Niccolò Bolli, Elisa Taiana, Antonino Neri

https://doi.org/10.3324/haematol.2021.278342

Apr 29, 2021

Editorials
Article

Carfilzomib or bortezomib in combination with cyclophosphamide and dexamethasone followed by carfilzomib maintenance for patients with multiple myeloma after one prior therapy: results from a multi-centre, phase II, randomized, controlled trial (MUKfive) (632 Online Views)

Kwee L. Yong, Samantha Hinsley, Holger W. Auner, Ceri Bygrave, Martin F. Kaiser, Karthik Ramasamy, Ruth M. de Tute, Debbie Sherratt, Louise Flanagan, Mamta Garg, Stephen Hawkins, Catherine Williams, Jamie Cavenagh, Neil K. Rabin, James Croft, Gareth Morgan, Faith Davies, Roger G. Owen, Sarah R. Brown

https://doi.org/10.3324/haematol.2021.278399

Editorials
Article

Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag (1184 Online Views)

Yoshitaka Zaimoku, Bhavisha A. Patel, Ruba Shalhoub, Emma M. Groarke, Xingmin Feng, Colin O. Wu, Neal S. Young

https://doi.org/10.3324/haematol.2021.278413

Articles

LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia (776 Online Views)

Gabriel Gracia-Maldonado, Jason Clark, Matthew Burwinkel, Brenay Greenslade, Mark Wunderlich, Nathan Salomonis, Dario Leone, Evelina Gatti, Philippe Pierre, Ashish R. Kumar, Lynn H. Lee

https://doi.org/10.3324/haematol.2020.257451

Apr 22, 2021

Editorials
Article

Evolutionary clonal trajectories in nodular lymphocyte predominant Hodgkin lymphoma with high transformation risk (525 Online Views)

Lisa Paschold, Edith Willscher, Julia Bein, Martine Vornanen, Dennis A. Eichenauer, Donjete Simnica, Benjamin Thiele, Claudia Wickenhauser, Andreas Rosenwald, Heinz-Wolfram Bernd, Wolfram Klapper, Alfred C. Feller, German Ott, Falko Fend, Sylvia Hartmann, Mascha Binder

https://doi.org/10.3324/haematol.2021.278427

Articles

Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy (381 Online Views)

Valentine Brousse, Corinne Pondarre, Manoelle Kossorotoff, Cecile Arnaud, Annie Kamdem, Mariane de Montalembert, Benedicte Boutonnat-Faucher, Slimane Allali, Hélène Bourdeau, Keyne Charlot, Sebastien Bertil, Lydie da Costa, Philippe Connes, David Grévent, Suzanne Verlhac

https://doi.org/10.3324/haematol.2020.278226

Apr 15, 2021

Articles

Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia (1027 Online Views)

Dan Cojocari, Brianna N Smith, Julie J. Purkal, Maria P. Arrate, Jason D. Huska, Yu Xiao, Agnieszka Gorska, Leah J. Hogdal, Haley E. Ramsey, Erwin R Boghaert, Darren C. Phillips, Michael R. Savona

https://doi.org/10.3324/haematol.2020.272609

Case Reports

Apr 8, 2021

Articles

Apr 1, 2021

Articles

Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (1046 Online Views)

Armando N. Bastidas Torres, Davy Cats, Jacoba J. Out-Luiting, Daniele Fanoni, Hailiang Mei, Luigia Venegoni, Rein Willemze, Maarten H. Vermeer, Emilio Berti, Cornelis P. Tensen

https://doi.org/10.3324/haematol.2020.274506

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma (1150 Online Views)

Man Chun John Ma, Saber Tadros, Alyssa Bouska, Tayla Heavican, Haopeng Yang, Qing Deng, Dalia Moore, Ariz Akhter, Keenan Hartert, Neeraj Jain, Jordan Showell, Sreejoyee Ghosh, Lesley Street, Marta Davidson, Christopher Carey, Joshua Tobin, Deepak Perumal, Julie M. Vose, Matthew A. Lunning, Aliyah R. Sohani, Benjamin J. Chen, Shannon Buckley, Loretta J. Nastoupil, R. Eric Davis, Jason R. Westin, Nathan H. Fowler, Samir Parekh, Maher Gandhi, Sattva Neelapu, Douglas Stewart, Kapil Bhalla, Javeed Iqbal, Timothy Greiner, Scott J. Rodig, Adnan Mansoor, Michael R. Green

https://doi.org/10.3324/haematol.2020.274258

Mar 25, 2021

Articles

Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance (615 Online Views)

Soracha E. Ward, Jamie M. O’Sullivan, Alan B. Moran, Daniel I. R. Spencer, Richard A. Gardner, Jyotika Sharma, Judicael Fazavana, Marco Monopoli, Thomas A.J. McKinnon, Alain Chion, Sandra Haberichter, James S. O’Donnell

https://doi.org/10.3324/haematol.2020.274720

Mar 18, 2021

Articles

β-thalassemia minor is a beneficial determinant of red blood cell storage lesion (628 Online Views)

Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Davide Stefanoni, Francesca Cendali, Lorenzo Bertolone, Fabia Gamboni, Monika Dzieciatkowska, Pantelis Rousakis, Athina Vergaki, Vassilis Soulakis, Ourania E. Tsitsilonis, Konstantinos Stamoulis, Issidora S. Papassideri, Anastasios G. Kriebardis, Angelo D’Alessandro, Marianna H. Antonelou

https://doi.org/10.3324/haematol.2020.273946

Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia (1014 Online Views)

Taeko Kaburagi, Genki Yamato, Norio Shiba, Kenichi Yoshida, Yusuke Hara, Ken Tabuchi, Yuichi Shiraishi, Kentaro Ohki, Manabu Sotomatsu, Hirokazu Arakawa, Hidemasa Matsuo, Akira Shimada, Tomohiko Taki, Nobutaka Kiyokawa, Daisuke Tomizawa, Keizo Horibe, Satoru Miyano, Takashi Taga, Souichi Adachi, Seishi Ogawa, Yasuhide Hayashi

https://doi.org/10.3324/haematol.2020.269431

Integrative prognostic models predict long-term survival after immunochemotherapy in chronic lymphocytic leukemia patients (544 Online Views)

Johannes Bloehdorn, Julia Krzykalla, Karlheinz Holzmann, Andreas Gerhardinger, Billy Michael Chelliah Jebaraj, Jasmin Bahlo, Kathryn Humphrey, Eugen Tausch, Sandra Robrecht, Daniel Mertens, Christof Schneider, Kirsten Fischer, Michael Hallek, Hartmut Döhner, Axel Benner, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2020.251561

Mar 11, 2021

Articles

Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients (650 Online Views)

Silvia Ramos-Campoy, Anna Puiggros, Sílvia Beà, Sandrine Bougeon, María José Larráyoz, Dolors Costa, Helen Parker, Gian Matteo Rigolin, Margarita Ortega, María Laura Blanco, Rosa Collado, Rocío Salgado, Tycho Baumann, Eva Gimeno, Carolina Moreno, Francesc Bosch, Xavier Calvo, María José Calasanz, Antonio Cuneo, Jonathan C. Strefford, Florence Nguyen-Khac, David Oscier, Claudia Haferlach, Jacqueline Schoumans, Blanca Espinet

https://doi.org/10.3324/haematol.2020.274456

Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune)therapy (677 Online Views)

Marc Zapatka, Eugen Tausch, Selcen Öztürk, Deyan Yordanov Yosifov, Martina Seiffert, Thorsten Zenz, Christof Schneider, Johannes Blöhdorn, Hartmut Döhner, Daniel Mertens, Peter Lichter, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2020.265777

ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells (647 Online Views)

Vikas Madan, Zeya Cao, Weoi Woon Teoh, Pushkar Dakle, Lin Han, Pavithra Shyamsunder, Maya Jeitany, Siqin Zhou, Jia Li, Hazimah Binte Mohd Nordin, JiZhong Shi, Shuizhou Yu, Henry Yang, Md Zakir Hossain, Wee Joo Chng, H. Phillip Koeffler

https://doi.org/10.3324/haematol.2020.260562

Feb 25, 2021

Articles

Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia (775 Online Views)

Eun-Ji Choi, Young-Uk Cho, Eun-Hye Hur, Seongsoo Jang, Nayoung Kim, Han-Seung Park, Jung-Hee Lee, Kyoo-Hyung Lee, Si-Hwan Kim, Sang-Hyun Hwang, Eul-Ju Seo, Chan-Jeoung Park, Je-Hwan Lee

https://doi.org/10.3324/haematol.2020.270553

Feb 18, 2021

Articles

Identification of a novel genetic locus associated with immune mediated thrombotic thrombocytopenic purpura (553 Online Views)

Matthew J. Stubbs, Paul Coppo, Chris Cheshire, Agnès Veyradier, Stephanie Dufek, Adam P. Levine, Mari Thomas, Vaksha Patel, John O. Connolly, Michael Hubank, Ygal Benhamou, Lionel Galicier, Pascale Poullin, Robert Kleta, Daniel P. Gale, Horia Stanescu, Marie A Scully

https://doi.org/10.3324/haematol.2020.274639

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma (1207 Online Views)

Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E. Robinson, Valentina S. Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W. Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris

https://doi.org/10.3324/haematol.2020.274480

The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia (674 Online Views)

Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak

https://doi.org/10.3324/haematol.2020.263756

Feb 11, 2021

Articles

Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia (818 Online Views)

Marion K. Mateos, Glenn M. Marshall, Pasquale M. Barbaro, Michael C.J. Quinn, Carly George, Chelsea Mayoh, Rosemary Sutton, Tamas Revesz, Jodie E. Giles, Draga Barbaric, Frank Alvaro, Françoise Mechinaud, Daniel Catchpoole, John A. Lawson, Georgia Chenevix-Trench, Stuart MacGregor, Rishi S. Kotecha, Luciano Dalla-Pozza, Toby N. Trahair

https://doi.org/10.3324/haematol.2020.268565

Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes (747 Online Views)

Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Giovanni A.M. Povoleri, Jessica A. Timms, Shahram Kordasti, Tanja D. de Gruijl, Arjan A. van de Loosdrecht

https://doi.org/10.3324/haematol.2020.268136

Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis (915 Online Views)

Rachel Dobson, Peter Y. Du, Lívia Rásó-Barnett, Wen-Qing Yao, Zi Chen, Calogero Casa, Hesham EI-Daly, Lorant Farkas, Elizabeth Soilleux, Penny Wright, John W. Grant, Manuel Rodriguez-Justo, George A. Follows, Hala Rashed, Margarete Fabre, E. Joanna Baxter, George Vassiliou, Andrew Wotherspoon, Ayoma D. Attygalle, Hongxiang Liu, Ming-Qing Du

https://doi.org/10.3324/haematol.2020.265991

Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates (1131 Online Views)

Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano Jr.

https://doi.org/10.3324/haematol.2020.260059

Jan 21, 2021

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Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation (454 Online Views)

Michela Faleschini, Nicole Papa, Marie-Christine Morel-Kopp, Caterina Marconi, Tania Giangregorio, Federica Melazzini, Valeria Bozzi, Marco Seri, Patrizia Noris, Alessandro Pecci, Anna Savoia, Roberta Bottega

https://doi.org/10.3324/haematol.2020.267328

Jan 14, 2021

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Long term follow-up of pediatric-onset Evans syndrome: broad immunopathological manifestations and high treatment burden (687 Online Views)

Thomas Pincez, Helder Fernandes, Thierry Leblanc, Gérard Michel, Vincent Barlogis, Yves Bertrand, Bénédicte Neven, Wadih Abou Chahla, Marlène Pasquet, Corinne Guitton, Aude Marie-Cardine, Isabelle Pellier, Corinne Armari-Alla, Joy Benadiba, Pascale Blouin, Eric Jeziorski, Frédéric Millot, Catherine Paillard, Caroline Thomas, Nathalie Cheikh, Sophie Bayart, Fanny Fouyssac, Christophe Piguet, Marianna Deparis, Claire Briandet, Eric Dore, Capucine Picard, Frédéric Rieux-Laucat, Judith Landman-Parker, Guy Leverger, Nathalie Aladjidi

https://doi.org/10.3324/haematol.2020.271106

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity (1648 Online Views)

Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger

https://doi.org/10.3324/haematol.2020.269670

Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector (1221 Online Views)

Yang Liu, Maria Dahl, Shubhranshu Debnath, Michael Rothe, Emma M. Smith, Tan Hooi Min Grahn, Sarah Warsi, Jun Chen, Johan Flygare, Axel Schambach, Stefan Karlsson

https://doi.org/10.3324/haematol.2020.269142

Human invariant natural killer T cells promote tolerance by preferential apoptosis induction of conventional dendritic cells (538 Online Views)

Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind

https://doi.org/10.3324/haematol.2020.267583

Jan 7, 2021

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Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multicentre nation-wide cohort (814 Online Views)

Maddalena Casale, Gian Luca Forni, Elena Cassinerio, Daniela Pasquali, Raffaella Origa, Marilena Serra, Saveria Campisi, Angelo Peluso, Roberta Renni, Alessandro Cattoni, Elisa De Michele, Massimo Allò, Maurizio Poggi, Francesca Ferrara, Rosanna Di Concilio, Filomena Sportelli, Antonella Quarta, Maria Caterina Putti, Lucia Dora Notarangelo, Antonella Sau, Saverio Ladogana, Immacolata Tartaglione, Stefania Picariello, Alessia Marcon, Patrizia Sturiale, Domenico Roberti, Antonio Ivan Lazzarino, Silverio Perrotta

https://doi.org/10.3324/haematol.2020.272419

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia. (2169 Online Views)

Rudy Birsen, Clement Larrue, Justine Decroocq, Natacha Johnson, Nathan Guiraud, Mathilde Gotanegre, Lilia Cantero-Aguilar, Eric Grignano, Tony Huynh, Michaela Fontenay, Olivier Kosmider, Patrick Mayeux, Nicolas Chapuis, Jean Emmanuel Sarry, Jerome Tamburini, Didier Bouscary

https://doi.org/10.3324/haematol.2020.259531

Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance (760 Online Views)

Martina Moras, Claude Hattab, Pedro Gonzalez-Menendez, Claudio M. Fader, Michael Dussiot, Jerome Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi Taylor, Sophie D. Lefevre, Mariano A. Ostuni

https://doi.org/10.3324/haematol.2020.257121

Dec 30, 2020

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CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide. (2542 Online Views)

Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer

https://doi.org/10.3324/haematol.2020.271908

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis (1089 Online Views)

Thomas Milan, Magalie Celton, Karine Lagacé, Élodie Roques, Safia Safa-Tahar-Henni, Eva Bresson, Anne Bergeron, Josée Hebert, Soheil Meshinchi, Sonia Cellot, Frédéric Barabé, Brian T Wilhelm

https://doi.org/10.3324/haematol.2020.271619

Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia (1006 Online Views)

Anna Hecht, Julia A. Meyer, Astrid Behnert, Eric Wong, Farid Chehab, Adam Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat, Jason E. Farrar, Mark Fluchel, Haydar Frangoul, Jennifer H. Han, Edward A. Kolb, Dennis J. Kuo, Margaret L. MacMillan, Luke Maese, Kelly W. Maloney, Aru Narendran, Benjamin Oshrine, Kirk R. Schultz, Maria L. Sulis, David Van Mater, Sarah K. Tasian, Wolf-Karsten Hofmann, Mignon L. Loh, Elliot Stieglitz

https://doi.org/10.3324/haematol.2020.270595

Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia (1206 Online Views)

Alisa Damnernsawad, Daniel Bottomly, Stephen E. Kurtz, Christopher A. Eide, Shannon K. McWeeney, Jeffrey W. Tyner, Tamilla Nechiporuk

https://doi.org/10.3324/haematol.2020.257964

Dec 23, 2020

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Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and resensitizes acute myeloid leukemia to BCL-2 inhibition (1339 Online Views)

Bing Z. Carter, Po Yee Mak, Wenjing Tao, Marc Warmoes, Philip L. Lorenzi, Duncan Mak, Vivian Ruvolo, Lin Tan, Justin Cidado, Lisa Drew, Michael Andreeff

https://doi.org/10.3324/haematol.2020.260331

Dec 17, 2020

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Baseline SUVmax is related to tumor cell proliferation and patient outcome in follicular lymphoma (940 Online Views)

Cédric Rossi, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, Don-Marc Franchini, Nadia Amara, Charlotte Syrykh, Pierre Bories, Lucie Oberic, Loïc Ysebaert, Laurent Martin, Selim Ramla, Philippine Robert, Claire Tabouret-Viaud, René-Olivier Casasnovas, Jean-Jacques Fournié, Christine Bezombes, Camille Laurent

https://doi.org/10.3324/haematol.2020.263194

Post-translational polymodification of β1-tubulin regulates motor protein localisation in platelet production and function (762 Online Views)

Abdullah O. Khan, Alexandre Slater, Annabel Maclachlan, Phillip L.R. Nicolson, Jeremy A. Pike, Jasmeet S. Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G. Thomas, Neil V. Morgan

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Dec 10, 2020

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Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway (1020 Online Views)

Tongjie Wang, Chengxiang Xia, Qitong Weng, Kaitao Wang, Yong Dong, Sha Hao, Fang Dong, Xiaofei Liu, Lijuan Liu, Yang Geng, Yuxian Guan, Juan Du, Tao Cheng, Hui Cheng, Jinyong Wang

https://doi.org/10.3324/haematol.2019.239186

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia (779 Online Views)

Alaeddin Khalil, Gudrun Würthwein, Jana Golitsch, Georg Hempel, Manfred Fobker, Joachim Gerss, Anja Möricke, Martin Zimmermann, Petr Smisek, Massimo Zucchetti, Christa Nath, Andishe Attarbaschi, Arend von Stackelberg, Nicola Gökbuget, Carmelo Rizzari, Valentino Conter, Martin Schrappe, Joachim Boos, Claudia Lanvers-Kaminsky

https://doi.org/10.3324/haematol.2020.258525

Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential (765 Online Views)

Lennart Raman, Malaïka Van der Linden, Ciel De Vriendt, Bliede Van den Broeck, Kristoff Muylle, Dries Deeren, Franceska Dedeurwaerdere, Sofie Verbeke, Amélie Dendooven, Katrien De Grove, Saskia Baert, Kathleen Claes, Björn Menten, Fritz Offner, Jo Van Dorpe

https://doi.org/10.3324/haematol.2020.268813

Dec 3, 2020

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Phenogenomic heterogeneity of post-transplant plasmablastic lymphomas (713 Online Views)

Rebecca J. Leeman-Neill, Craig R. Soderquist, Francesca Montanari, Patricia Raciti, David Park, Dejan Radeski, Mahesh M. Mansukhani, Vundavalli V. Murty, Susan Hsiao, Bachir Alobeid, Govind Bhagat

https://doi.org/10.3324/haematol.2020.267294

Autologous stem cell transplantation is safe and effective for fit older myeloma patients: exploratory results from the Myeloma XI trial (860 Online Views)

Charlotte Pawlyn, David Cairns, Tom Menzies, John Jones, Matthew Jenner, Gordon Cook, Kevin Boyd, Mark Drayson, Martin Kaiser, Roger Owen, Walter Gregory, Gareth Morgan, Graham Jackson, Faith Davies

https://doi.org/10.3324/haematol.2020.262360

Nov 26, 2020

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Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis (1046 Online Views)

Sheila Bohler, Sehar Afreen, Juncal Fernandez-Orth, Eva-Maria Demmerath, Christian Molnar, Ying Wu, Julia Miriam Weiss, Venugopal Rao Mittapalli, Lukas Konstantinidis, Hagen Schmal, Mirjam Kunze, Miriam Erlacher

https://doi.org/10.3324/haematol.2020.252130

The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion (791 Online Views)

Audrey Astori, Gabriel Matherat, Isabelle Munoz, Emilie-Fleur Gautier, Didier Surdez, Yaël Zermati, Frédérique Verdier, Sakina Zaidi, Vincent Feuillet, Amir Kadi, Evelyne Lauret, Olivier Delattre, Carine Lefèvre, Michaela Fontenay, Evelyne Ségal-Bendirdjian, Isabelle Dusanter-Fourt, Didier Bouscary, Olivier Hermine, Patrick Mayeux, Frédéric Pendino

https://doi.org/10.3324/haematol.2020.263558

Nov 19, 2020

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Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells (713 Online Views)

Sandra Romero Marquez, Franziska Hettler, Renate Hausinger, Christina Schreck, Theresa Landspersky, Lynette Henkel, Corinne Angerpointner, Ihsan E. Demir, Matthias Schiemann, Florian Bassermann, Katharina S. Götze, Rouzanna Istvánffy, Robert A.J. Oostendorp

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Bone marrow megakaryocytic activation predicts fibrotic evolution of Philadelphia-negative myeloproliferative neoplasms (1209 Online Views)

Mattia Schino, Vincenzo Fiorentino, Elena Rossi, Silvia Betti, Monica Di Cecca, Valentina Ranucci, Patrizia Chiusolo, Maurizio Martini, Valerio De Stefano, Luigi Maria Larocca

https://doi.org/10.3324/haematol.2020.264143

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways (754 Online Views)

Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling

https://doi.org/10.3324/haematol.2020.267500

Nov 12, 2020

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A prognostic index predicting survival in transformed Waldenström macroglobulinemia (1134 Online Views)

Eric Durot, Lukshe Kanagaratnam, Saurabh Zanwar, Efstathios Kastritis, Shirley D’Sa, Ramon Garcia-Sanz, Cécile Tomowiak, Bénédicte Hivert, Elise Toussaint, Caroline Protin, Jithma P. Abeykoon, Thomas Guerrero-Garcia, Gilad Itchaki, Josephine M. Vos, Anne-Sophie Michallet, Sophie Godet, Jehan Dupuis, Stéphane Leprêtre, Joshua Bomsztyk, Pierre Morel, Véronique Leblond, Steven P. Treon, Meletios A. Dimopoulos, Prashant Kapoor, Alain Delmer, Jorge J. Castillo

https://doi.org/10.3324/haematol.2020.262899

Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project (1047 Online Views)

Claudia Sargas, Rosa Ayala, María Carmen Chillón, María J. Larráyoz, Estrella Carrillo-Cruz, Cristina Bilbao, Manuel Yébenes-Ramírez, Marta Llop, Inmaculada Rapado, Ramón García-Sanz, Iria Vázquez, Elena Soria, Yanira Florido-Ortega, Kamila Janusz, Carmen Botella, Josefina Serrano, David Martínez-Cuadrón, Juan Bergua, Mari Luz Amigo, Pilar Martínez-Sánchez, Mar Tormo, Teresa Bernal, Pilar Herrera-Puente, Raimundo García, Lorenzo Algarra, María J. Sayas, Lisette Costilla-Barriga, Esther Pérez-Santolalla, Inmaculada Marchante, Esperanza Lavilla-Rubira, Víctor Noriega, Juan M. Alonso-Domínguez, Miguel Á. Sanz, Joaquín Sánchez-Garcia, María T. Gómez-Casares, José A. Pérez-Simón, María J. Calasanz, Marcos González-Díaz, Joaquín Martínez-López, Eva Barragán, Pau Montesinos

https://doi.org/10.3324/haematol.2020.263806

Nov 5, 2020

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PVRIG is a novel NK cell immune checkpoint receptor in acute myeloid leukemia (2169 Online Views)

Jessica Li, Sarah Whelan, Maya F. Kotturi, Deborah Meyran, Criselle D’Souza, Kyle Hansen, Spencer Liang, John Hunter, Joseph A. Trapani, Paul J. Neeson

https://doi.org/10.3324/haematol.2020.258574

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations (1166 Online Views)

Željko Antić, Jiangyan Yu, Simon V. van Reijmersdal, Anke van Dijk, Linde Dekker, Wouter H. Segerink, Edwin Sonneveld, Marta Fiocco, Rob Pieters, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Ad Geurts van Kessel, Esme Waanders, Roland P. Kuiper

https://doi.org/10.3324/haematol.2020.259226

Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo (1112 Online Views)

Mara N. Zeissig, Duncan R. Hewett, Vasilios Panagopoulos, Krzysztof M. Mrozik, L. Bik To, Peter I. Croucher, Andrew C.W. Zannettino, Kate Vandyke

https://doi.org/10.3324/haematol.2020.253526

Oct 29, 2020

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Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities (811 Online Views)

Caroline Scott, Damien J. Downes, Jill M. Brown, Robert Beagrie, Aude-Anais Olijnik, Matthew Gosden, Ron Schwessinger, Christopher A. Fisher, Anna Rose, David J.P Ferguson, Errin Johnson, Quentin A. Hill, Steven Okoli, Raffaele Renella, Kate Ryan, Marjorie Brand, Jim Hughes, Noemi B.A. Roy, Douglas R. Higgs, Christian Babbs, Veronica J. Buckle

https://doi.org/10.3324/haematol.2020.260158

Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria (1714 Online Views)

Antonio M. Risitano, Austin G. Kulasekararaj, Jong Wook Lee, Jaroslaw P. Maciejewski, Rosario Notaro, Robert Brodsky, Mingjun Huang, Michael Geffner, Peter Browett

https://doi.org/10.3324/haematol.2020.261826

Use of the HLA-B leader to optimize cord-blood transplantation (772 Online Views)

Effie W. Petersdorf, Ted Gooley, Fernanda Volt, Chantal Kenzey, Alejandro Madrigal, Caroline McKallor, Sergio Querol, Hanadi Rafii, Vanderson Rocha, Ryad Tamouza, Christian Chabannon, Annalisa Ruggeri, Eliane Gluckman

https://doi.org/10.3324/haematol.2020.264424

Venetoclax plus bendamustine-rituximab or bendamustine-obinutuzumab in chronic lymphocytic leukemia: final results of a phase 1b study (GO28440) (1405 Online Views)

Stephan Stilgenbauer, Franck Morschhauser, Clemens-Martin Wendtner, Guillaume Cartron, Michael Hallek, Barbara Eichhorst, Mark F. Kozloff, Thomas Giever, Gerard Lozanski, Yanwen Jiang, Huang Huang, Daniela Soriano Pignataro, William Schary, Kathryn Humphrey, Mehrdad Mobasher, Gilles Salles

https://doi.org/10.3324/haematol.2020.261107

SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation (764 Online Views)

Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei

https://doi.org/10.3324/haematol.2020.261891

Oct 13, 2020

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Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice (677 Online Views)

Manfred Nairz, Christoph Metzendorf, Maja Vujic-Spasic, Anna-Maria Mitterstiller, Andrea Schroll, David Haschka, Alexander Hoffmann, Laura von Raffay, Richard Sparla, Christian W. Huck, Heribert Talasz, Patrizia L. Moser, Martina U. Muckenthaler, Günter Weiss

https://doi.org/10.3324/haematol.2019.241745

Plasmacytoid dendritic cells proliferation associated with acute myeloid leukemia: phenotype profile and mutation landscape (1317 Online Views)

Loria Zalmaï, Pierre-Julien Viailly, Sabeha Biichle, Meyling Cheok, Lou Soret, Fanny Angelot-Delettre, Tony Petrella, Marie-Agnès Collonge-Rame, Estelle Seilles, Sandrine Geffroy, Eric Deconinck, Etienne Daguindau, Sabrina Bouyer, Elodie Dindinaud, Victor Baunin, Magali Le Garff-Tavernier, Damien Roos-Weil, Orianne Wagner-Ballon, Véronique Salaun, Jean Feuillard, Sophie Brun, Bernard Drenou, Caroline Mayeur-Rousse, Patricia Okamba, Véronique Dorvaux, Michel Tichionni, Johann Rose, Marie Thérèse Rubio, Marie Christine Jacob, Victoria Raggueneau, Claude Preudhomme, Philippe Saas, Christophe Ferrand, Olivier Adotevi, Christophe Roumier, Fabrice Jardin, Francine Garnache-Ottou, Florian Renosi

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Oct 5, 2020

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Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans (913 Online Views)

Daniel C.J. Ferguson, Juraidah Haji Mokim, Marjolein Meinders, Edmund R.R. Moody, Tom A. Williams, Sarah Cooke, Kongtana Trakarnsanga, Deborah E. Daniels, Ivan Ferrer-Vicens, Deborah Shoemark, Chartsiam Tipgomut, Katherine A. Macinnes, Marieangela C. Wilson, Belinda K. Singleton, Jan Frayne

https://doi.org/10.3324/haematol.2020.256347

Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration (1883 Online Views)

Deborah M. Stephens, Ken Boucher, Elizabeth Kander, Sameer A. Parikh, Erin M. Parry, Mazyar Shadman, John M. Pagel, Jennifer Cooperrider, Joanna Rhodes, Anthony Mato, Allison Winter, Brian Hill, Sameh Gaballa, Alexey Danilov, Tycel Phillips, Danielle M. Brander, Sonali M. Smith, Matthew Davids, Kerry Rogers, Martha J. Glenn, John C. Byrd

https://doi.org/10.3324/haematol.2020.256388

Sep 28, 2020

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Engineered type 1 regulatory T cells designed for clinical use kill primary pediatric acute myeloid leukemia cells (1076 Online Views)

Brandon Cieniewicz, Molly Javier Uyeda, Ping (Pauline) Chen, Ece Canan Sayitoglu, Jeffrey Mao-Hwa Liu, Grazia Andolfi, Katharine Greenthal, Alice Bertaina, Silvia Gregori, Rosa Bacchetta, Norman James Lacayo, Alma-Martina Cepika, Maria Grazia Roncarolo

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Platelet proteome and function in X–linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome (1353 Online Views)

Daniel Bergemalm, Sofia Ramström, Caroline Kardeby, Kjell Hultenby, Anna Göthlin Eremo, Carina Sihlbom, Jörgen Bergström, Jan Palmblad, Maria Åström

https://doi.org/10.3324/haematol.2020.249805

Sep 21, 2020

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Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro (973 Online Views)

Thomas Hoefer, Akshita Rana, Be'eri Niego, Shweta Jagdale, Hugo J. Albers, Elizabeth E. Gardiner, Robert K. Andrews, Andries D. Van der Meer, Christoph E. Hagemeyer, Erik Westein

https://doi.org/10.3324/haematol.2020.250761

Sep 14, 2020

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Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma (1167 Online Views)

Youssef Youssef, Vrajesh Karkhanis, Wing Keung Chan, Frankie Jeney, Alessandro Canella, Xiaoli Zhang, Shelby Sloan, Alexander Prouty, JoBeth Helmig-Mason, Liudmyla Tsyba, Walter Hanel, Xuguang Zheng, Pu Zhang, Ji-Hyun Chung, David M. Lucas, Zachary Kauffman, Karilyn Larkin, Anne M. Strohecker, Hatice G. Ozer, Rosa Lapalombella, Hui Zhou, Zijun Y. Xu-Monette, Ken H. Young, Ruolan Han, Elmar Nurmemmedov, Gerard Nuovo, Kami Maddocks, John C. Byrd, Robert A. Baiocchi, Lapo Alinari

https://doi.org/10.3324/haematol.2020.268235

The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis (843 Online Views)

Mahran Shoukier, Gautam Borthakur, Elias Jabbour, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Jairo Matthews, Lucia Masarova, Kiran Naqvi, Koji Sasaki, Srdan Verstovsek, Jorge Cortes

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Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations (1017 Online Views)

Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak

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Sep 10, 2020

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CDKN2A deletion is a frequent event associated with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) (880 Online Views)

Francesco Maura, Anna Dodero, Cristiana Carniti, Niccolò Bolli, Martina Magni, Valentina Monti, Antonello Cabras, Daniel Leongamornlert, Federico Abascal, Benjamin Diamond, Bernardo Rodriguez-Martin, Jorge Zamora, Adam Butler, Inigo Martincorena, Jose M. C. Tubio, Peter J. Campbell, Annalisa Chiappella, Giancarlo Pruneri, Paolo Corradini

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Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells (557 Online Views)

Angelo D’Alessandro, Ariel Hay, Monika Dzieciatkowska, Benjamin C. Brown, Evan J Morrison, Kirk C. Hansen, James C Zimring

https://doi.org/10.3324/haematol.2020.266676

Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency (820 Online Views)

Birgit van Dooijeweert, Melissa H. Broeks, Nanda M. Verhoeven-Duif, Eduard J. van Beers, Edward E.S. Nieuwenhuis, Wouter W. van Solinge, Marije Bartels, Judith J. Jans, Richard van Wijk

https://doi.org/10.3324/haematol.2020.266957

Aug 27, 2020

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Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype (1371 Online Views)

Antonio Vogelsberg, Julia Steinhilber, Barbara Mankel, Birgit Federmann, Janine Schmidt, Ivonne A. Montes-Mojarro, Katrin Hüttl, Maria Rodriguez-Pinilla, Praveen Baskaran, Sven Nahnsen, Miguel A. Piris, German Ott, Leticia Quintanilla-Martinez, Irina Bonzheim, Falko Fend

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Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease (1227 Online Views)

Sara El Hoss, Sylvie Cochet, Auria Godard, Hongxia Yan, Michaël Dussiot, Giacomo Frati, Bénédicte Boutonnat-Faucher, Sandrine Laurance, Olivier Renaud, Laure Joseph, Annarita Miccio, Valentine Brousse, Mohandas Narla, Wassim El Nemer

https://doi.org/10.3324/haematol.2020.265462

Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNFα, IL-6 and IL-11 cytokines (822 Online Views)

Paolo Giannoni, Cecilia Marini, Giovanna Cutrona, Serena Matis, Maria Cristina Capra, Francesca Puglisi, Paola Luzzi, Simona Pigozzi, Gabriele Gaggero, Antonino Neri, Katia Todoerti, Fortunato Morabito, Adalberto Ibatici, Maurizio Miglino, Micaela Bergamaschi, Silvia Bruno, Gian Mario Sambuceti, Jean Louis Ravetti, Manlio Ferrarini, Franco Fais, Daniela de Totero

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