Early view

Perspective Article

Novel dynamic outcome indicators and clinical endpoints in myelodysplastic syndrome; the European LeukemiaNet MDS Registry and MDS-RIGHT project perspective

Theo de Witte, Luca Malcovati, Pierre Fenaux, David Bowen, Argiris Symeonidis, Moshe Mittelman, Reinhard Stauder, Guillermo Sanz, Jaroslav Čermák, Saskia Langemeijer, Eva Hellström-Lindberg, Ulrich Germing, Mette Skov Holm, Krzysztof Mądry, Aurelia Tatic, António Medina Almeida, Aleksandar Savic, Inga Mandac Rogulj, Raphael Itzykson, Marlijn Hoeks, Hege Gravdahl Garelius, Dominic Culligan, Ioannis Kotsianidis, Lionel Ades, Arjan A. Van de Loosdrecht, Corine van Marrewijk, Ge Yu, Simon Crouch, Alex Smith

Articles

Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro

Thomas Hoefer, Akshita Rana, Be'eri Niego, Shweta Jagdale, Hugo J. Albers, Elizabeth E. Gardiner, Robert K. Andrews, Andries D. Van der Meer, Christoph E. Hagemeyer, Erik Westein

Review Articles

Why is it critical to achieve a deep molecular response in chronic myeloid leukemia?

Susan Branford

Review Articles

Translational and clinical advances in acute graft-versus-host disease

Mahasweta Gooptu, John Koreth

Articles

Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma

Youssef Youssef, Vrajesh Karkhanis, Wing Keung Chan, Frankie Jeney, Alessandro Canella, Xiaoli Zhang, Shelby Sloan, Alexander Prouty, JoBeth Helmig-Mason, Liudmyla Tsyba, Walter Hanel, Xuguang Zheng, Pu Zhang, Ji-Hyun Chung, David M. Lucas, Zachary Kauffman, Karilyn Larkin, Anne M. Strohecker, Hatice G. Ozer, Rosa Lapalombella, Hui Zhou, Zijun Y. Xu-Monette, Ken H. Young, Ruolan Han, Elmar Nurmemmedov, Gerard Nuovo, Kami Maddocks, John C. Byrd, Robert A. Baiocchi, Lapo Alinari

Articles

The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis.

Mahran Shoukier, Gautam Borthakur, Elias Jabbour, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Jairo Matthews, Lucia Masarova, Kiran Naqvi, Koji Sasaki, Srdan Verstovsek, Jorge Cortes

Articles

A deep molecular response of splenic marginal zone lymphoma to front-line checkpoint blockade

Peter G. Miller, Adam S. Sperling, Christopher J. Gibson, Olga Pozdnyakova, Waihay J. Wong, Michael P. Manos, Elizabeth I. Buchbinder, F. Stephen Hodi, Benjamin L. Ebert, Matthew S. Davids

Articles

Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations

Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak

Articles

Intravenous iron preparations transiently generate non-transferrin-bound iron from two proposed pathways

Maciej W. Garbowski, Sukhvinder Bansal, John B. Porter, Claudio Mori, Susanna Burckhardt, Robert C. Hider

Letters to the Editor

Very low incidence of Clostridioides difficile infection in pediatric sickle cell disease patients

Philip Lee, Arpan A. Sinha, Vijaya L. Soma, Carlos Cruz, Tao Wang, Olga Aroniadis, Betsy C. Herold, Paul S. Frenette, David L. Goldman, Deepa Manwani

Centenary Review

Pediatric acute lymphoblastic leukemia

Hiroto Inaba, Charles G. Mullighan

Articles

CDKN2A deletion is a frequent event associated with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS)

Francesco Maura, Anna Dodero, Cristiana Carniti, Niccolò Bolli, Martina Magni, Valentina Monti, Antonello Cabras, Daniel Leongamornlert, Federico Abascal, Benjamin Diamond, Bernardo Rodriguez-Martin, Jorge Zamora, Adam Butler, Inigo Martincorena, Jose M. C. Tubio, Peter J. Campbell, Annalisa Chiappella, Giancarlo Pruneri, Paolo Corradini

Articles

No evidence of hemoglobin damage by SARS-CoV-2 infection

Anthony W. DeMartino, Jason J. Rose, Matthew B. Amdahl, Matthew R. Dent, Faraaz A. Shah, William Bain, Bryan J. McVerry, Georgios D. Kitsios, Jesús Tejero, Mark T. Gladwin

Articles

Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells

Angelo D’Alessandro, Ariel Hay, Monika Dzieciatkowska, Benjamin C. Brown, Evan J Morrison, Kirk C. Hansen, James C Zimring

Articles

Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency

Birgit van Dooijeweert, Melissa H. Broeks, Nanda M. Verhoeven-Duif, Eduard J. van Beers, Edward E.S. Nieuwenhuis, Wouter W. van Solinge, Marije Bartels, Judith J. Jans, Richard van Wijk

Letters to the Editor

Quantitative PCR-based chimerism in bone marrow or peripheral blood to predict acute myeloid leukemia relapse in high-risk patients: results from the KIM-PB prospective study

Valentina Gambacorta, Riccardo Parolini, Elisabetta Xue, Raffaella Greco, Evelien E. Bouwmans, Cristina Toffalori, Fabio Giglio, Andrea Assanelli, Maria Teresa Lupo Stanghellini, Alessandro Ambrosi, Benedetta Mazzi, Wietse Mulder, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri, Luca Vago

Letters to the Editor

Detectable mutations precede late myeloid neoplasia in aplastic anemia

Bhavisha A. Patel, Jack Ghannam, Emma M. Groarke, Meghali Goswami, Laura Dillon, Fernanda Gutierrez-Rodrigues, Olga Rios, Diego Quinones Raffo, Jennifer Lotter, Neal S. Young, Christopher S. Hourigan

Letters to the Editor

Exosomes-driven lipolysis and bone marrow niche remodeling supports leukemia expansion

Bijender Kumar, Marvin Orellana, Jamison Brooks, Srideshikan Sargur Madabushi, Paresh Vishwasrao, Liliana E. Parra, James Sanchez, Amandeep Salhotra, Anthony Stein, Ching-Cheng Chen, Guido Marcucci, Susanta Kumar Hui

Letters to the Editor

Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients

Paul Telfer, Josu de la Fuente, Mamta Sohal, Ralph Brown, Perla Eleftheriou, Noémi Roy, Frédéric B. Piel, Subarna Chakravorty, Kate Gardner, Mark Velangi, Emma Drasar, Farrukh Shah, John B. Porter, Sara Trompeter, Wale Atoyebi, Richard Szydlo, Kofi A. Anie, Kate Ryan, Joseph Sharif, Josh Wright, Emma Astwood, C. Sarah Nicolle, Amy Webster, David J. Roberts, Sanne Lugthart, Banu Kaya, Moji Awogbade, David C. Rees, Rob Hollingsworth, Baba Inusa, Jo Howard, D. Mark Layton

Articles

Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype

Antonio Vogelsberg, Julia Steinhilber, Barbara Mankel, Birgit Federmann, Janine Schmidt, Ivonne A. Montes-Mojarro, Katrin Hüttl, Maria Rodriguez-Pinilla, Praveen Baskaran, Sven Nahnsen, Miguel A. Piris, German Ott, Leticia Quintanilla-Martinez, Irina Bonzheim, Falko Fend

Articles

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease

Sara El Hoss, Sylvie Cochet, Auria Godard, Hongxia Yan, Michaël Dussiot, Giacomo Frati, Bénédicte Boutonnat-Faucher, Sandrine Laurance, Olivier Renaud, Laure Joseph, Annarita Miccio, Valentine Brousse, Mohandas Narla, Wassim El Nemer

Articles

Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system

Barbara Maurer, Tania Brandstoetter, Sebastian Kollmann, Veronika Sexl, Michaela Prchal-Murphy

Articles

Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNFα, IL-6 and IL-11 cytokines.

Paolo Giannoni, Cecilia Marini, Giovanna Cutrona, Serena Matis, Maria Cristina Capra, Francesca Puglisi, Paola Luzzi, Simona Pigozzi, Gabriele Gaggero, Antonino Neri, Katia Todoerti, Fortunato Morabito, Adalberto Ibatici, Maurizio Miglino, Micaela Bergamaschi, Silvia Bruno, Gian Mario Sambuceti, Jean Louis Ravetti, Manlio Ferrarini, Franco Fais, Daniela de Totero

Articles

Clinical significance of chromatin-spliceosome acute myeloid leukemia: a report from the Northern Italy Leukemia Group (NILG) randomized trial 02/06

Chiara Caprioli, Federico Lussana, Silvia Salmoiraghi, Roberta Cavagna, Ksenija Buklijas, Lara Elidi, Pamela Zanghi', Anna Michelato, Federica Delaini, Elena Oldani, Tamara Intermesoli, Anna Grassi, Giacomo Gianfaldoni, Francesco Mannelli, Dario Ferrero, Ernesta Audisio, Elisabetta Terruzzi, Lorella De Paoli, Chiara Cattaneo, Erika Borlenghi, Irene Cavattoni, Monica Tajana, Anna Maria Scattolin, Daniele Mattei, Paolo Corradini, Leonardo Campiotti, Fabio Ciceri, Massimo Bernardi, Elisabetta Todisco, Agostino Cortelezzi, Brunangelo Falini, Chiara Pavoni, Renato Bassan, Orietta Spinelli, Alessandro Rambaldi

Articles

Combinatorial molecule screening identifies a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells

Simon Hultmark, Aurélie Baudet, Ludwig Schmiderer, Pavan Prabhala, Sara Palma-Tortosa, Carl Sandén, Thoas Fioretos, Rajkumar Sasidharan, Christer Larsson, Sören Lehmann, Gunnar Juliusson, Fredrik Ek, Mattias Magnusson

Articles

Oxidative stress activates red cell adhesion to laminin in sickle cell disease

Maria Alejandra Lizarralde-Iragorri, Sophie D. Lefevre, Sylvie Cochet, Sara El Hoss, Valentine Brousse, Anne Filipe, Michael Dussiot, Slim Azouzi, Caroline Le Van Kim, Fernando Rodrigues-Lima, Olivier Français, Bruno Le Pioufle, Thomas Klei, Robin van Bruggen, Wassim El Nemer

Letters to the Editor

Hemostatic alterations in COVID-19

Flora Peyvandi, Andrea Artoni, Cristina Novembrino, Stefano Aliberti, Mauro Panigada, Marco Boscarino, Roberta Gualtierotti, Federica Rossi, Roberta Palla, Ida Martinelli, Giacomo Grasselli, Francesco Blasi, Armando Tripodi

Letters to the Editor

How to implement endurance exercise training in sickle cell disease

Laurent A. Messonnier, Manon Riccetti, Benjamin Chatel, Frédéric Galactéros, Barnabas Gellen, Thomas Rupp, Léonard Féasson, Pablo Bartolucci

Review Articles

New insights into the basic biology of acute graft-versus-host-disease

Alicia Li, Ciril Abraham, Ying Wang, Yi Zhang

Review Articles

The molecular basis for the prothrombotic state in sickle cell disease

Arun S. Shet, Maria A. Lizarralde-Iragorri, Rakhi P. Naik

Articles

Interleukin-1 receptor inhibition reduces stroke size in a murine model of sickle cell disease

Jessica Venugopal, Jintao Wang, Jalal Mawri, Chiao Guo, Daniel Eitzman

Articles

Efficacy, safety and immunological profile of combining rituximab with belimumab for adults with persistent or chronic immune thrombocytopenia: results from a prospective phase 2b trial

Matthieu Mahévas, Imane Azzaoui, Etienne Crickx, Florence Canoui-Poitrine, Delphine Gobert, Laetitia Languille, Nicolas Limal, Constance Guillaud, Laure Croisille, Mohamed Jeljeli, Fréderic Batteux, Samia Baloul, Olivier Fain, France Pirenne, Jean-Claude Weill, Claude-Agnès Reynaud, Bertrand Godeau, Marc Michel

Articles

A 3-gene signature based on MYC, BCL-2 and NFKBIA improves risk stratification in diffuse large B-cell lymphoma.

Enrico Derenzini, Saveria Mazzara, Federica Melle, Giovanna Motta, Marco Fabbri, Riccardo Bruna, Claudio Agostinelli, Alessandra Cesano, Chiara Antonia Corsini, Ning Chen, Simona Righi, Elena Sabattini, Annalisa Chiappella, Angelica Calleri, Stefano Fiori, Valentina Tabanelli, Antonello Cabras, Giancarlo Pruneri, Umberto Vitolo, Alessandro Massimo Gianni, Alessandro Rambaldi, Paolo Corradini, Pier Luigi Zinzani, Corrado Tarella, Stefano Pileri

Letters to the Editor

Molecular Attributes Underlying Central Nervous System and Systemic Relapse in Diffuse Large B-cell Lymphoma

Keren Isaev, Daisuke Ennishi, Laura Hilton, Brian Skinnider, Karen L. Mungall, Andrew J. Mungall, Mehran Bakhtiari, Rosemarie Tremblay-LeMay, Anjali Silva, Susana Ben-Neriah, Merrill Boyle, Diego Villa, Marco A. Marra, Christian Steidl, Randy D. Gascoyne, Ryan Morin, Kerry J. Savage, David W. Scott, Robert Kridel

Letters to the Editor

Lack of activation-induced cytidine deaminase expression in in situ follicular neoplasia

Tanu Goyal, Sarah L. Ondrejka, Juraj Bodo, Lisa Durkin, Eric D. Hsi

Letters to the Editor

The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia

Yun Zhou, Haiwei Lian, Ning Shen, Sovannarith Korm, Andrew Kwok Ping Lam, Olivia Layton, Leah N. Huiting, Dun Li, Kelly Miao, Aozhuo Zeng, Esther Landesman-Bollag, David C. Seldin, Hui Fu, Li Hong, Hui Feng

Letters to the Editor

Gender-specific transcriptional profiles identified in β-thalassemia patients

Aikaterini Nanou, Chrisavgi Toumpeki, Pavlos Fanis, Nicoletta Bianchi, Lucia Carmela Cosenza, Cristina Zuccato, George Sentis, Giorgos Giagkas, Coralea Stephanou, Marios Phylactides, Soteroula Christou, Michalis Hadjigavriel, Maria Sitarou, Carsten W. Lederer, Roberto Gambari, Marina Kleanthous, Eleni Katsantoni

Case Reports

Clonal independence of JAK2 and CALR or MPL mutations in co-mutated myeloproliferative neoplasms demonstrated by single cell DNA sequencing

Ella R. Thompson, Tamia Nguyen, Yamuna Kankanige, Paul Yeh, Michael Ingbritsen, Michelle McBean, Timothy Semple, Gisela Mir Arnau, Kate Burbury, Nora Lee, Amit Khot, David Westerman, Piers Blombery

Case Reports

Severe delayed hemolytic transfusion reaction due to anti-Fy3 in a patient with sickle cell disease undergoing red cell exchange prior to hematopoietic progenitor cell collection for gene therapy

Elizabeth F. Stone, Scott T. Avecilla, David L. Wuest, Christine Lomas-Francis, Connie M. Westhoff, David L. Diuguid, Michel Sadelain, Farid Boulad, Patricia A. Shi

Case Reports

Monoclonal gammopathy of clinical significance: In vivo demonstration of the anti-thrombotic effect of an acquired Anti-Thrombin Antibody

Berenice Schell, Celine Desconclois, Xavier Mariette, Cecile Goujard, Peter J. Lenting, Cecile V. Denis, Valerie Proulle

Case Reports

Treatment with emapalumab in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis-related graft failure and disseminated BCGitis

Francesca Tucci, Vera Gallo, Federica Barzaghi, Francesca Ferrua, Maddalena Migliavacca, Valeria Calbi, Matteo Doglio, Elena Sophia Fratini, Zeynep Karakas, Sukru Guner, Matilde Zambelli, Cristina Parisi, Raffaella Milani, Salvatore Gattillo, Benedetta Mazzi, Chiara Oltolini, Maurizio Barbera, Cristina Baldoli, Daniela Maria Cirillo, Veronica Asnaghi, Cristina De Min, Maria Pia Cicalese, Fabio Ciceri, Alessandro Aiuti, Maria Ester Bernardo

Articles

A pilot study of ruxolitinib as a front-line therapy for 12 children with secondary hemophagocytic lymphohistiocytosis

Qing Zhang, Ang Wei, Hong-Hao Ma, Li Zhang, Hong-Yun Lian, Dong Wang, Yun-Ze Zhao, Lei Cui, Wei-Jing Li, Ying Yang, Tian-You Wang, Zhi-Gang Li, Rui Zhang

Articles

Impaired nodal shrinkage and apoptosis define the independent adverse outcome of NOTCH1 mutated patients under ibrutinib therapy in chronic lymphocytic leukaemia

Giovanni Del Poeta, Annalisa Biagi, Luca Laurenti, Annalisa Chiarenza, Federico Pozzo, Idanna Innocenti, Massimiliano Postorino, Francesca Maria Rossi, Maria Ilaria Del Principe, Riccardo Bomben, Paolo de Fabritiis, Antonio Bruno, Maria Cantonetti, Francesco Di Raimondo, Antonella Zucchetto, Valter Gattei

Articles

3D co-culture model of chronic lymphocytic leukemia bone marrow microenvironment predicts patient-specific response to mobilizing agents

Federica Barbaglio, Daniela Belloni, Lydia Scarfò, Francesca Vittoria Sbrana, Maurilio Ponzoni, Lucia Bongiovanni, Luca Pavesi, Desiree Zambroni, Kostas Stamatopoulos, Valeria R. Caiolfa, Elisabetta Ferrero, Paolo Ghia, Cristina Scielzo

Articles

Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1

Gehong Dong, Yuping Li, Logan Lee, Xuxiang Liu, Yunfei Shi, Xiaoqian Liu, Alyssa Bouska, Qiang Gong, Lingbo Kong, Jinhui Wang, Chih-Hong Lou, Timothy W. McKeithan, Javeed Iqbal, Wing C. Chan

Articles

Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus

Petros Kountouris, Kyriaki Michailidou, Soteroula Christou, Michael Hadjigavriel, Maria Sitarou, Anita Kolnagou, Marina Kleanthous, Paul Telfer

Articles

MYB bi-allelic targeting abrogates primitive clonogenic progenitors while the emergence of primitive blood cells is not affected

Zahir Shah, Elena S. Filonenko, Vasily Ramensky, Chenyu Fan, Cuihua Wang, Hanif Ullah, Baoyun Zhang, Pavel Volchkov, Igor M. Samokhvalov

Articles

Elastography improves accuracy of early hepato-biliary complications diagnosis after allogeneic stem cell transplantation

Pierre-Edouard Debureaux, Pierre Bourrier, Pierre-Emmanuel Rautou, Anne-Marie Zagdanski, Morgane De Boutiny, Simona Pagliuca, Aurélien Sutra Del Galy, Marie Robin, Régis Peffault de Latour, Aurélie Plessier, Flore Sicre de Fontbrune, Aliénor Xhaard, Pedro Henrique de Lima Prata, Dominique Valla, Gérard Socié, David Michonneau

Articles

Altered T-cell subset repertoire affects treatment outcome of patients with myelofibrosis

Ivo Veletic, Sanja Prijic, Taghi Manshouri, Graciela M. Nogueras-Gonzalez, Srdan Verstovsek, Zeev Estrov

Articles

Hematopoietic recovery and immune reconstitution after axicabtagene ciloleucel in patients with large B-cell lymphoma

Paolo Strati, Ankur Varma, Sherry Adkins, Loretta J. Nastoupil, Jason Westin, Fredrick B. Hagemeister, Nathan H. Fowler, Hun J. Lee, Luis E. Fayad, Felipe Samaniego, Sairah Ahmed, Yiming Chen, Sandra Horowitz, Sara Arafat, Swapna Johncy, Partow Kebriaei, Victor Eduardo Mulanovich, Ella Ariza Heredia, Sattva S. Neelapu

Articles

Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse

Esther Onecha, Inmaculada Rapado, María Luz Morales, Gonzalo Carreño-Tarragona, Pilar Martinez-Sanchez, Xabier Gutierrez, José María Sáchez Pina, María Linares, Miguel Gallardo, Joaquín Martinez-López, Rosa Ayala

Articles

Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat

Elisabeth Oppliger Leibundgut, Monika Haubitz, Bart Burington, Oliver G. Ottmann, Gary Spitzer, Olatoyosi Odenike, Michael A. McDevitt, Alexander Röth, David S. Snyder, Gabriela M. Baerlocher

Letters to the Editor

Clinical characteristics and outcome of multiple myeloma patients with concomitant COVID-19 at Comprehensive Cancer Centers in Germany

Monika Engelhardt, Khalid Shoumariyeh, Amelie Rösner, Gabriele Ihorst, Francesca Biavasco, Katharina Meckel, Ivana von Metzler, Sebastian Treurich, Holger Hebart, Matthias Grube, Miriam Kull, Florian Bassermann, Kerstin Schäfer-Eckart, Anette Hoferer, Hermann Einsele, Leo Rasche, Ralph Wäsch

Case Reports

Acute leucoencephalomyelopathy and quadriparesis after CAR T-cell therapy

Ranjit Nair, Gaëlle Drillet, Faustine Lhomme, Anthony Le Bras, Laure Michel, John Rossi, Marika Sherman, Allen Xue, Anne Kerber, Nutchawan Jittapiromsak, Linda Chi, Sudhakar Tummala, Sattva S. Neelapu, Roch Houot

Case Reports

Eculizumab for complement mediated thrombotic microangiopathy in sickle cell disease

Satheesh Chonat, Sara Graciaa, H. Stella Shin, Joanna G. Newton, Maa-Ohui Quarmyne, Jeanne Boudreaux, Amy Tang, Patricia E. Zerra, Margo R. Rollins, Cassandra D. Josephson, Clark Brown, Clinton H. Joiner, Ross M. Fasano, Sean R. Stowell

Centenary Review

Multiple myeloma: the (r)evolution of current therapy and a glance into future

Annamaria Gulla, Kenneth C. Anderson

Review Articles

Potential targeting of FLT3 AML

Alexander J. Ambinder, Mark Levis

Articles

CAMT-MPL: Congenital Amegakaryocytic Thrombocytopenia caused by MPL mutations - Heterogeneity of a monogenic disorder - Comprehensive analysis of 56 patients

Manuela Germeshausen, Matthias Ballmaier

Articles

Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating beta2 integrin clustering

Gabriele Zuchtriegel, Bernd Uhl, Robert Pick, Michaela Ramsauer, Julian Dominik, Laura A. Mittmann, Martin Canis, Sandip Kanse, Markus Sperandio, Fritz Krombach, Christoph A. Reichel

Articles

Cell type specific novel lncRNAs and circRNAs in the BLUEPRINT haematopoietic transcriptomes atlas.

Luigi Grassi, Osagie G. Izuogu, Natasha A.N. Jorge, Denis Seyres, Mariona Bustamante, Frances Burden, Samantha Farrow, Neda Farahi, Fergal J. Martin, Adam Frankish, Jonathan M. Mudge, Myrto Kostadima, Romina Petersen, John J. Lambourne, Sophia Rowlston, Enca Martin-Rendon, Laura Clarke, Kate Downes, Xavier Estivill, Paul Flicek, Joost H.A. Martens, Marie-Laure Yaspo, Hendrik G. Stunnenberg, Willem H. Ouwehand, Fabio Passetti, Ernest Turro, Mattia Frontini

Articles

Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma. A proof of concept single arm multicenter trial

Cesare Perotti, Fausto Baldanti, Raffaele Bruno, Claudia Del Fante, Elena Seminari, Salvatore Casari, Elena Percivalle, Claudia Glingani, Valeria Musella, Mirko Belliato, Martina Garuti, Federica Meloni, Marilena Frigato, Antonio Di Sabatino, Catherine Klersy, Giuseppe De Donno, Massimo Franchini, Covid-19 plasma task force

Letters to the Editor

Complement C5 inhibition in patients with COVID-19 - a promising target?

Regis Peffault de Latour, Anne Bergeron, Etienne Lengline, Thibault Dupont, Armance Marchal, Lionel Galicier, Nathalie de Castro, Louise Bondeelle, Michael Darmon, Clairelyne Dupin, Guillaume Dumas, Pierre Leguen, Isabelle Madelaine, Sylvie Chevret, Jean-Michel Molina, Elie Azoulay, Veronique Fremeaux-Bacchi, CORE GROUP

Letters to the Editor

Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR

Audrey Belot, Ophélie Gourbeyre, Anais Palin, Aude Rubio, Amélie Largounez, Céline Besson-Fournier, Chloé Latour, Megane Lorgouilloux, Inka Gallitz, Alexandra Montagner, Arnaud Polizzi, Marion Régnier, Sarra Smati, An-Sheng Zhang, Manuel D. Diaz-Munoz, Andrea U. Steinbicker, Hervé Guillou, Marie-Paule Roth, Hélène Coppin, Delphine Meynard

Letters to the Editor

Perforin gene variant A91V in young patients with severe COVID-19.

Oscar Cabrera-Marante, Edgard Rodríguez de Frías, Daniel E. Pleguezuelo, Luis M. Allende, Antonio Serrano, Rocío Laguna-Goya, María Esther Mancebo, Paloma Talayero, Luis Álvarez-Vallina, Pablo Morales, Maria José Castro-Panete, Estela Paz-Artal

Letters to the Editor

ABO blood groups are not associated with risk of acquiring the SARS-CoV-2 infection in young adults

Laurys Boudin, Frédéric Janvier, Olivier Bylicki, Fabien Dutasta

Case Reports

Apparent recessive inheritance of sideroblastic anemia type 2 due to uniparental isodisomy at the SLC25A38 locus

Immacolata Andolfo, Stefania Martone, Michela Ribersani, Simona Bianchi, Francesco Manna, Rita Genesio, Antonella Gambale, Piero Pignataro, Anna Maria Testi, Achille Iolascon, Roberta Russo

Articles

Co-occurrence of cohesin complex and Ras signaling mutations during progression from myelodysplastic syndromes to secondary acute myeloid leukemia

Marta Martín-Izquierdo, María Abáigar, Jesús M Hernández-Sánchez, David Tamborero, Félix López-Cadenas, Fernando Ramos, Eva Lumbreras, Andrés Madinaveitia-Ochoa, Marta Megido, Jorge Labrador, Javier Sánchez-Real, Carmen Olivier, Julio Dávila, Carlos Aguilar, Juan N Rodríguez, Guillermo Martín-Nuñez, Sandra Santos-Mínguez, Cristina Miguel-García, Rocío Benito, María Díez-Campelo, Jesús M Hernández-Rivas

Articles

Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B cell–type diffuse large B-cell lymphoma

Lorenz Thurner, Sylvia Hartmann, Moritz Bewarder, Natalie Fadle, Evi Regitz, Claudia Schormann, Natalia Quiroga, Maria Kemele, Wolfram Klapper, Andreas Rosenwald, Lorenz Trümper, Rainer Maria Bohle, Anna Nimmesgern, Christina Körbel, Matthias W. Lascke, Michael D. Menger, Stefan Barth, Boris Kubuschok, Anja Mottok, Dominic Kaddu-Mulindwa, Martin-Leo Hansmann, Viola Pöschel, Gerhard Held, Niels Murawski, Stephan Stilgenbauer, Frank Neumann, Klaus-Dieter Preuss, Michael Pfreundschuh

Articles

Endothelial damage and dysfunction in acute graft-versus-host disease

Steffen Cordes, Zeinab Mokhtari, Maria Bartosova, Sarah Mertlitz, Katarina Riesner, Yu Shi, Jörg Mengwasser, Martina Kalupa, Aleixandria McGeary, Johanna Schleifenbaum, Jens Schrezenmeier, Lars Bullinger, Maribel Diaz-Ricart, Marta Palomo, Enric Carrreras, Gernot Beutel, Claus Peter Schmitt, Andreas Beilhack, Olaf Penack

Articles

BMP signaling is required for postnatal murine hematopoietic stem cell self-renewal

Sarah Warsi, Ulrika Blank, Maria Dahl, Tan Hooi Min Grahn, Ludwig Schmiderer, Silja Andradottir, Stefan Karlsson

Articles

An international, multicenter study of intravenous bevacizumab for bleeding in hereditary hemorrhagic telangiectasia: the InHIBIT-Bleed study

Hanny Al-Samkari, Raj S. Kasthuri, Joseph G. Parambil, Hasan A. Albitar, Yahya A. Almodallal, Carolina Vázquez, Marcelo M. Serra, Sophie Dupuis-Girod, Craig B. Wilsen, Justin P. McWilliams, Evan H. Fountain, James R. Gossage, Clifford R. Weiss, Muhammad A. Latif, Assaf Issachar, Meir Mei-Zahav, Mary E. Meek, Miles Conrad, Josanna Rodriguez-Lopez, David J. Kuter, Vivek N. Iyer

Articles

Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect

Eileen Haring, Franziska M. Uhl, Geoffroy Andrieux, Michele Proietti, Alla Bulashevska, Barbara Sauer, Lukas M. Braun, Enrique de Vega Gomez, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Marie Follo, Annette Schmitt-Graeff, Joerg Buescher, Justus Duyster, Bodo Grimbacher, Melanie Boerries, Erika L. Pearce, Robert Zeiser, Petya Apostolova

Articles

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

Christian W. Thorball, Tiphaine Oudot-Mellakh, Nava Ehsan, Christian Hammer, Federico A. Santoni, Jonathan Niay, Dominique Costagliola, Cécile Goujard, Laurence Meyer, Sophia S. Wang, Shehnaz K. Hussain, Ioannis Theodorou, Matthias Cavassini, Andri Rauch, Manuel Battegay, Matthias Hoffmann, Patrick Schmid, Enos Bernasconi, Huldrych F. Günthard, Pejman Mohammadi, Paul J. McLaren, Charles S. Rabkin, Caroline Besson, Jacques Fellay

Articles

Fenofibrate reduces osteonecrosis without affecting antileukemic efficacy in dexamethasone treated mice

Emily R. Finch, Monique A. Payton, David A. Jenkins, Xiangjun Cai, Lie Li, Seth E. Karol, Mary V. Relling, Laura J. Janke

Letters to the Editor

Bi 38-3 is a novel CD38/CD3 bispecific T-cell engager with low toxicities for the treatment of multiple myeloma.

Maxime Fayon, Carolina Martinez-Cingolani, Audrey Abecassis, Nathalie Roders, Elisabeth Nelson, Caroline Choisy, Alexis Talbot, Armand Bensussan, Jean-Paul Fermand, Bertrand Arnulf, Jean-Christophe Bories

Case Reports

First description of revertant mosaicism in familial platelet disorder with predisposition to acute myelogenous leukemia: correlation with the clinical phenotype

Ana C. Glembotsky, Cecilia P. Marin Oyarzún, Geraldine De Luca, Christophe Marzac, Nathalie Auger, Nora P. Goette, Rosana F. Marta, Hana Raslova, Paula G. Heller

Articles

DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch

Michaela Novakova, Marketa Zaliova, Karel Fiser, Barbora Vakrmanova, Lucie Slamova, Alena Musilova, Monika Brüggemann, Matthias Ritgen, Eva Fronkova, Tomas Kalina, Jan Stary, Lucie Winkowska, Peter Svec, Alexandra Kolenova, Jan Stuchly, Jan Zuna, Jan Trka, Ondrej Hrusak, Ester Mejstrikova

Articles

Survival of patients with newly diagnosed high-grade myeloid neoplasms who do not meet standard trial eligibility

Mary-Elizabeth M. Percival, Megan Othus, Sarah Mirahsani, Kelda M. Gardner, Carole Shaw, Anna B. Halpern, Pamela S. Becker, Paul C. Hendrie, Mohamed L. Sorror, Roland B. Walter, Elihu H. Estey

Letters to the Editor

Effect of post-consolidation regimen on symptomatic osteonecrosis in three DCOG acute lymphoblastic leukemia protocols

Jenneke E. van Atteveld, Hester A. de Groot-Kruseman, Marta Fiocco, Maarten H. Lequin, Sebastian J.C.M.M. Neggers, Saskia M.F. Pluijm, Inge M. van der Sluis, Rob Pieters, Marry M. van den Heuvel-Eibrink

Letters to the Editor

Homozygous missense variant in UBE2T is associated with mild Fanconi anemia phenotype

Laura Schultz-Rogers, Francis P. Lach, Kimberly A. Rickman, Alejandro Ferrer, Abhishek A. Mangaonkar, Tanya L. Schwab, Christopher T. Schmitz, Karl J. Clark, Nikita R. Dsouza, Michael T. Zimmermann, Mark Litzow, Nicole Jacobi, Eric W. Klee, Agata Smogorzewska, Mrinal M. Patnaik

Articles

Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity

Lando Janssen, Nicole M.A. Blijlevens, Meggie M.C.M. Drissen, Esmée A. Bakker, Malou A.H. Nuijten, Jeroen J.W.M. Janssen, Silvie Timmers, Maria T.E. Hopman

Articles

CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity

Julia C. Gutjahr, Elisabeth Bayer, Xiaobing Yu, Julia M. Laufer, Jan P. Höpner, Suzana Tesanovic, Andrea Härzschel, Georg Auer, Tanja Rieß, Astrid Salmhofer, Eva Szenes, Theresa Haslauer, Valerie Durand-Onayli, Andrea Ramspacher, Sandra P. Pennisi, Marc Artinger, Nadja Zaborsky, Alexandre Chigaev, Fritz Aberger, Daniel Neureiter, Lisa Pleyer, Daniel F. Legler, Veronique Orian-Rousseau, Richard Greil, Tanja N. Hartmann

Case Reports

Anti-C5 antibody treatment for delayed hemolytic transfusion reactions in sickle cell disease

Aline Floch, Alexandre Morel, Fabian Zanchetta-Balint, Catherine Cordonnier-Jourdin, Slimane Allali, Maximilien Grall, Ghislaine Ithier, Benjamin Carpentier, Sadaf Pakdaman, Jean-Claude Merle, Radjiv Goulabchand, Tackwa Khalifeh, Ana Berceanu, Cécile Helmer, Christelle Chantalat-Auger, Véronique Frémeaux-Bacchi, Marc Michel, Mariane de Montalembert, Armand Mekontso-Dessap, France Pirenne, Anoosha Habibi, Pablo Bartolucci

Case Reports

Dramatic presentation of acquired thombotic thrombocytopenic purpura associated with COVID-19

Marco Capecchi, Cristina Mocellin, Chiara Abbruzzese, Ilaria Mancini, Daniele Prati, Flora Peyvandi

Articles

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor

Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore, Charity Atkins, Edward R. Long, Monica N. Montoute, Zining Wu, Wendy Halsey, Dean E. McNulty, Daniela Ennulat, Lourdes Rueda, Melissa Pappalardi, Ryan G. Kruger, Michael T. McCabe, Ali Raoof, Roger Butlin, Alexandra Stowell, Mark Cockerill, Ian Waddell, Donald Ogilvie, Juan Luengo, Allan Jordan, Andrew B. Benowitz

Articles

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis

Ana B. Arroyo, María P. Fernández-Pérez, Alberto del Monte, Sonia Águila, Raúl Méndez, Rebecca Hernández-Antolín, Nuria García-Barber, Ascensión M de los Reyes-García, Paula González-Jiménez, María I. Arcas, Vicente Vicente, Rosario Menéndez, Vicente Andrés, Rocío González-Conejero, Constantino Martínez

Articles

Membrane protein CAR promotes hematopoietic regeneration upon stress

Guojin Wu, Cheng Cheng Zhang

Letters to the Editor

Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis

Fredrik H. Schjesvold, Paul G. Richardson, Thierry Facon, Adrián Alegre, Andrew Spencer, Artur Jurczyszyn, Kazutaka Sunami, Laurent Frenzel, Chang-Ki Min, Sophie Guillonneau, Peggy L. Lin, Solenn Le-Guennec, Frank Campana, Helgi van de Velde, Samira Bensfia, Sara Bringhen

Letters to the Editor

Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma.

Keiichiro Watanabe, Ariunzaya Bat-Erdene, Hirofumi Tenshin, Qu Cui, Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Takeshi Harada, Hirokazu Miki, Kimiko Sogabe, Masahiro Oura, Ryohei Sumitani, Yukari Mitsui, Itsuro Endo, Eiji Tanaka, Makoto Kawatani, Hiroyuki Osada, Toshio Matsumoto, Masahiro Abe

Letters to the Editor

Infrequent "chronic lymphocytic leukemia-specific" immunoglobulin stereotypes in aged individuals with or without low count monoclonal B cell lymphocytosis

Andreas Agathangelidis, Chrysi Galigalidou, Lydia Scarfò, Theodoros Moysiadis, Alessandra Rovida, Maria Gounari, Fotis Psomopoulos, Pamela Ranghetti, Alex Galanis, Frederic Davi, Kostas Stamatopoulos, Anastasia Chatzidimitriou, Paolo Ghia

Articles

Impact on survival through consolidation radiotherapy for diffuse large B-cell lymphoma: a comprehensive meta-analysis

Martin D. Berger, Sven Trelle, Annina E. Büchi, Sabrina Jegerlehner, Codruta Ionescu, Thierry Lamy de la Chapelle, Urban Novak

Articles

Comparison of total body irradiation versus non- total body irradiation containing regimens for de novo acute myeloid leukemia in children

Christopher E. Dandoy, Stella M. Davies, Kwang Woo Ahn, Yizeng He, Anders E. Kolb, John Levine, Stephanie Bo-Subait, Hisham Abdel-Azim, Neel Bhatt, Joseph Chewing, Shahinaz Gadalla, Nicholas Gloude, Robert Hayashi, Nahal R. Lalefar, Jason Law, Margaret MacMillan, Tracy O'Brien, Timothy Prestidge, Akshay Sharma, Peter Shaw, Lena Winestone, Mary Eapen

Letters to the Editor

Transfer of stem cell niche-residential regulatory T cells prevents post-irradiation bone marrow injury

Miwako Kakiuchi, Yuichi Hirata, Simon C. Robson, Joji Fujisaki

Letters to the Editor

Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance.

Hannah Åbacka, Jesper S. Hansen, Peng Huang, Raminta Venskutonytė, Axel Hyrenius-Wittsten, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Filippo Minutolo, Anna K. Hagström-Andersson, Karin Lindkvist-Petersson

Letters to the Editor

Human platelets are a source of collagen I

Anastasia Kyselova, Sven Zukunft, Deborah Puppe, Ilka Wittig, W. Alexander Mann, Imke Dornauf, Ingrid Fleming, Voahanginirina Randriamboavonjy

Letters to the Editor

Germline pathogenic variants in transcription factors predisposing to pediatric acute myeloid leukemia: results from the French ELAM02 trial

Laurène Fenwarth, Nicolas Duployez, Alice Marceau-Renaut, Wadih Abou Chahla, Stéphane Ducassou, Virginie Gandemer, Marlène Pasquet, Thierry Leblanc, Pascale Schneider, Carine Domenech, Paul Saultier, Guy Leverger, Hélène Lapillonne, Claude Preudhomme, Arnaud Petit

Letters to the Editor

Concomitant constitutive LNK and NFE2 mutation with loss of sumoylation in a case of hereditary thrombocythemia

Lukas Clemens Böckelmann, Titiksha Basu, Albert Gründer, Wei Wang, Jan Breucker, Sandra Kaiser, Andrea Pichler, Heike Luise Pahl

Articles

Efficacy of minimal residual disease driven immune-intervention after allogeneic hematopoietic stem cell transplantation for high-risk chronic lymphocytic leukemia: results of a prospective multicentric trial

Olivier Tournilhac, Magali Le Garff-Tavernier, Stéphanie Nguyen Quoc, Edouard Forcade, Patrice Chevallier, Faezeh Legrand-Izadifar, Gandhi Laurent Damaj, David Michonneau, Cécile Tomowiak, Cécile Borel, Corentin Orvain, Pascal Turlure, Rabah Redjou, Gaëlle Guillerm, Laure Vincent, Celestine Simand, Richard Lemal, Claire Quiney, Patricia Combes, Bruno Pereira, Laure Calvet, Aurélie Cabrespine, Jacques-Olivier Bay, Véronique Leblond, Nathalie Dhédin, French Innovative Leukemia Organization (FILO), Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

Articles

Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay

Gaëtan Juban, Nathalie Sakakini, Hedia Chagraoui, David Cruz Hernandez, Qian Cheng, Kelly Soady, Bilyana Stoilova, Catherine Garnett, Dominic Waithe, Georg Otto, Jessica Doondeea, Batchimeg Usukhbayar, Elena Karkoulia, Maria Alexiou, John Strouboulis, Edward Morrissey, Irene Roberts, Catherine Porcher, Paresh Vyas

Articles

Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential

Aled O'Neill, Desmond Chin, Darren Tan, A Qilah Banu Bte Abdul Majeed, Ayako Nakamura-Ishizu, Toshio Suda

Case Reports

COVID-19 in patients with sickle cell disease - a case series from a UK Tertiary Hospital

Subarna Chakravorty, Giselle Padmore-Payne, Fester Ike, Virginia Tshibangu, Charlotte Graham, David Rees, Sara Stuart-Smith

Articles

Allogeneic hematopoietic cell transplantation with non-myeloablative conditioning for patients with hematologic malignancies: Improved outcomes over two decades

Jason P. Cooper, Barry E. Storer, Noa Granot, Boglark Gyurkocza, Mohamed L. Sorror, Thomas R. Chauncey, Judith Shizuru, Georg-Nikolaus Franke, Michael B. Maris, Michael Boyer, Benedetto Bruno, Firoozeh Sahebi, Amelia A. Langston, Parameswaran Hari, Edward D. Agura, Søren Lykke Petersen, Richard T. Maziarz, Wolfgang Bethge, Julie Asch, Jonathan A. Gutman, Gitte Olesen, Andrew M. Yeager, Kai Hübel, William J. Hogan, David G. Maloney, Marco Mielcarek, Paul J. Martin, Mary E.D. Flowers, George E. Georges, Ann E. Woolfrey, H. Joachim Deeg, Bart L. Scott, George B. McDonald, Rainer Storb, Brenda M. Sandmaier

Articles

Fc-engineering significantly improves the recruitment of immune effector cells by anti-ICAM-1 antibody MSH-TP15 for myeloma therapy

Katja Klausz, Michael Cieker, Christian Kellner, Thies Rösner, Anna Otte, Steffen Krohn, Anja Lux, Falk Nimmerjahn, Thomas Valerius, Martin Gramatzki, Matthias Peipp

Articles

Lenalidomide before and after ASCT for transplant-eligible patients of all ages in the randomized, phase III, Myeloma XI trial

Graham H. Jackson, Faith E. Davies, Charlotte Pawlyn, David A. Cairns, Alina Striha, Corinne Collett, Anna Waterhouse, John R. Jones, Bhuvan Kishore, Mamta Garg, Cathy D. Williams, Kamaraj Karunanithi, Jindriska Lindsay, David Allotey, Salim Shafeek, Matthew W. Jenner, Gordon Cook, Nigel H. Russell, Martin F. Kaiser, Mark T. Drayson, Roger G. Owen, Walter M. Gregory, Gareth J. Morgan, UK NCRI Haematological Oncology Clinical Studies Group

Articles

A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies

Hanny Al-Samkari, Aric D. Parnes, Katayoon Goodarzi, James I. Weitzman, Jean M. Connors, David J. Kuter

Articles

Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores the angiogenic homeostasis and suppresses tumor progression.

Antonio G. Solimando, Matteo C. Da Vià, Patrizia Leone, Paola Borrelli, Giorgio A. Croci, Paula Tabares, Andreas Brandl, Giuseppe Di Lernia, Francesco P. Bianchi, Silvio Tafuri, Torsten Steinbrunn, Alessandra Balduini, Assunta Melaccio, Simona De Summa, Antonella Argentiero, Hilka Rauert-Wunderlich, Maria A. Frassanito, Paolo Ditonno, Erik Henke, Wolfram Klapper, Roberto Ria, Carolina Terragna, Leo Rasche, Andreas Rosenwald, K. Martin Kortüm, Michele Cavo, Domenico Ribatti, Vito Racanelli, Hermann Einsele, Angelo Vacca, Andreas Beilhack

Letters to the Editor

Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression

Ivan Sloma, Philip Beer, Christophe Desterke, Elizabeth Bulaeva, Misha Bilenky, Annaïck Carles, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G. Turhan, Orianne Wagner-Ballon, Philippe Gaulard, Keith Humphries, Martin Hirst, Connie J. Eaves

Letters to the Editor

Frequency and prognostic impact of ZEB2 H1038 and 1072 mutations in childhood B-other acute lymphoblastic leukemia

Marketa Zaliova, Eliska Potuckova, Julius Lukes, Lucie Winkowska, Julia Starkova, Iveta Janotova, Lucie Sramkova, Jan Stary, Jan Zuna, Martin Stanulla, Martin Zimmermann, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert, Gunnar Cario, Jan Trka

Letters to the Editor

Outcomes of relapsed or refractory acute myeloid leukemia after frontline hypomethylating agent and venetoclax regimens

Abhishek Maiti, Caitlin R. Rausch, Jorge E. Cortes, Naveen Pemmaraju, Naval G. Daver, Farhad Ravandi, Guillermo Garcia-Manero, Gautam Borthakur, Kiran Naqvi, Maro Ohanian, Nicholas J. Short, Yesid Alvarado, Tapan M. Kadia, Koichi Takahashi, Musa Yilmaz, Nitin Jain, Steven Kornblau, Guillermo Montalban Bravo, Koji Sasaki, Michael Andreeff, Prithiviraj Bose, Alessandra Ferrajoli, Ghayas C. Issa, Elias J. Jabbour, Lucia Masarova, Philip A. Thompson, Sa Wang, Sergej Konoplev, Sherry A. Pierce, Jing Ning, Wei Qiao, John S. Welch, Hagop M. Kantarjian, Courtney D. DiNardo, Marina Y. Konopleva

Articles

Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913

Sabina Chiaretti, Monica Messina, Irene Della Starza, Alfonso Piciocchi, Luciana Cafforio, Marzia Cavalli, Akram Taherinasab, Michela Ansuinelli, Loredana Elia, Guglielmo Albertini Petroni, Roberta La Starza, Martina Canichella, Alessia Lauretti, Maria Ctristina Puzzolo, Valentina Pierini, Alessandra Santoro, Orietta Spinelli, Valerio Apicella, Saveria Capria, Francesco Di Raimondo, Paolo De Fabritiis, Cristina Papayannidis, Anna Candoni, Roberto Cairoli, Marco Cerrano, Nicola Fracchiolla, Daniele Mattei, Chiara Cattaneo, Antonella Vitale, Enrico Crea, Paola Fazi, Cristina Mecucci, Alessandro Rambaldi, Anna Guarini, Renato Bassan, Robin Foà

Articles

Deciphering the Ets-1/2-mediated transcriptional regulation of F8 gene identifies a minimal F8 promoter for hemophilia A gene therapy

Rosella Famà, Ester Borroni, Simone Merlin, Chiara Airoldi, Silvia Pignani, Alessia Cucci, Davide Corà, Valentina Bruscaggin, Sharon Scardellato, Stefania Faletti, Giuliana Pelicci, Mirko Pinotti, Gillian E. Walker, Antonia Follenzi

Articles

Anti-RhD antibody therapy modulates human natural killer cell function

Shlomo Elias, Inbal Kol, Shira Kahlon, Rajaa Amore, Mariam Zeibak, Dror Mevorach, Uriel Elchalal, Orly Zelig, Ofer Mandelboim

Articles

Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling

Amanda J. Unsworth, Alexander P. Bye, Tanya Sage, Renato S. Gaspar, Nathan Eaton, Caleb Drew, Alexander Stainer, Neline Kriek, Peter J. Volberding, James L. Hutchinson, Ryan Riley, Sarah Jones, Stuart J. Mundell, Weiguo Cui, Hervé Falet, Jonathan M. Gibbins

Articles

Hemoglobin switching in mice carrying the Klf1Nan variant

Anne Korporaal, Nynke Gillemans, Steven Heshusius, Ileana Cantú, Emile van den Akker, Thamar B. van Dijk, Marieke von Lindern, Sjaak Philipsen

Letters to the Editor

Clinical spectrum and therapeutic management of auto-immune myelofibrosis: a nation-wide study of 30 cases

Philippe Mertz, Emilie Chalayer, Zahir Amoura, Pascal Cathebras, Laurent Chiche, Nathalie Coestedoat, Alban Deroux, Elisabeth Diot, Stéphane Durupt, Emmanuel Forestier, Audrey Gorse, Laurent Hudier, Martin Killian, Olivier Lambotte, Claire Lecomte, Emmanuel Ledoult, Camille Martinez, Alexis Mathian, Anne Sophie Morin, Nicolas Noel, Marc Pineton De Chambrun, Louis Terriou, Jean Sibilia, Jacques-Eric Gottenberg, Anne-Sophie Korganow, Laurent Arnaud, Thierry Martin

Review Articles

Thromboinflammatory mechanisms in sickle cell disease - challenging the hemostatic balance

Nicola Conran, Erich V. De Paula

Articles

2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance

Alisa Dong, Valentina Ghiaccio, Irene Motta, Shuling Guo, Raechel Peralta, Susan M. Freier, Andy Watt, Sagar Damle, Yasuhiro Ikawa, Danuta Jarocha, Maxwell Chappell, Coralea Stephanou, Paola Delbini, Connie Chen, Soteroula Christou, Marina Kleanthous, Kim Smith-Whitley, Deepa Manwani, Carla Casu, Osheiza Abdulmalik, Maria Domenica Cappellini, Stefano Rivella, Laura Breda

Articles

Eltrombopag monotherapy can improve hematopoiesis in patients with low to intermediate risk-1 myelodysplastic syndrome

Alana Vicente, Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Emma Groarke, Valentina Giudice, Jennifer Lotter, Xingmin Feng, Sachiko Kajigaya, Barbara Weinstein, Evette Barranta, Matthew J. Olnes, Ankur R. Parikh, Maher Albitar, Colin O. Wu, Ruba Shalhoub, Katherine R. Calvo, Danielle M. Townsley, Phillip Scheinberg, Cynthia E. Dunbar, Neal S. Young, Thomas Winkler

Articles

Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

Sigal Tavor, Tali Shalit, Noa Chapal Ilani, Yoni Moskovitz, Nir Livnat, Yoram Groner, Haim Barr, Mark D. Minden, Alexander Plotnikov, Michael W. Deininger, Nathali Kaushansky, Liran I. Shlush

Articles

A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia

Hiroki Mizumaki, Kazuyoshi Hosomichi, Kohei Hosokawa, Takeshi Yoroidaka, Tatsuya Imi, Yoshitaka Zaimoku, Takamasa Katagiri, Mai Anh Thi Nguyen, Dung Cao Tran, Mahmoud Ibrahim Yousef Elbadry, Kazuhisa Chonabayashi, Yoshinori Yoshida, Hiroyuki Takamatsu, Tatsuhiko Ozawa, Fumihiro Azuma, Hiroyuki Kishi, Yoichi Fujii, Seishi Ogawa, Atsushi Tajima, Shinji Nakao

Articles

Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia

Chujing Zhang, Stella Amanda, Cheng Wang, Tze King Tan, Muhammad Zulfaqar Ali, Wei Zhong Leong, Ley Moy Ng, Shojiro Kitajima, Zhenhua Li, Allen Eng Juh Yeoh, Shi Hao Tan, Takaomi Sanda

Articles

Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma

Naoki Oishi, Tanya Hundal, Jessica L. Phillips, Surendra Dasari, Guangzhen Hu, David S. Viswanatha, Rong He, Ming Mai, Hailey K. Jacobs, Nada H. Ahmed, Sergei I. Syrbu, Youssef Salama, Jennifer R. Chapman, Francisco Vega, Jagmohan Sidhu, N. Nora Bennani, Alan L. Epstein, L. Jeffrey Medeiros, Mark W. Clemens, Roberto N. Miranda, Andrew L. Feldman

Articles

Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models

Raghuveer Singh Mali, Qi Zhang, RosaAnna DeFilippis, Antonio Cavazos, Vinitha Mary Kuruvilla, Jayant Raman, Vidhi Mody, Edna F. Choo, Monique Dail, Neil P. Shah, Marina Konopleva, Deepak Sampath, Elisabeth A. Lasater

Articles

Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia

Nyla A. Heerema, Natarajan Muthusamy, Qiuhong Zhao, Amy S. Ruppert, Heather Breidenbach, Leslie A. Andritsos, Michael R. Grever, Kami J. Maddocks, Jennifer Woyach, Farrukh Awan, Meixiao Long, Amber Gordon, Caitlin Coombes, John C. Byrd

Articles

Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia

Joseph P. Loftus, Anella Yahiaoui, Patrick A. Brown, Lisa M. Niswander, Asen Bagashev, Min Wang, Allyson Schauf, Stacey Tannheimer, Sarah K. Tasian

Articles

Brentuximab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone as frontline treatment for patients with CD30-positive B-cell lymphomas

Jakub Svoboda, Steven M. Bair, Daniel J. Landsburg, Sunita Dwivedy Nasta, Sarah J. Nagle, Stefan K. Barta, Nadia Khan, Joanne Filicko-O'Hara, Sameh Gaballa, Lauren Strelec, Elise Chong, Sheryl Mitnick, Terease S. Waite, Cara King, Hatcher Ballard, Matthew Youngman, James Gerson, John P. Plastaras, Amit Maity, Agata M. Bogusz, Stacy S. Hung, Hisae Nakamura, Reza Nejati, Christian Steidl, Megan Lim, Marco Ruella, Stephen J. Schuster

Letters to the Editor

Validation of the revised myeloma comorbidity index and other comorbidity scores in a multicenter German study group multiple myeloma trial

Sandra Maria Dold, Mandy-Deborah Möller, Gabriele Ihorst, Christian Langer, Wolfram Pönisch, Lars-Olof Mügge, Stefan Knop, Johannes Jung, Christine Greil, Ralph Wäsch, Monika Engelhardt

Letters to the Editor

CCND2 mutations are infrequent events in BCR-ABL1 negative myeloproliferative neoplasm patients

Bruno Cassinat, Emmanuelle Verger, Nabih Maslah, Nicolas Gauthier, William Vainchenker, Stéphane Giraudier, Jean-Jacques Kiladjian

Articles

The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia

Teresa D'Altri, Anna S. Wilhelmson, Mikkel B. Schuster, Anne Wenzel, Adrija Kalvisa, Sachin Pundhir, Anne Meldgaard Hansen, Bo T. Porse

Articles

Analysis of the tumor microenvironment by whole-slide image analysis identifies low B cell content as a predictor of adverse outcome in advanced-stage classical Hodgkin lymphoma treated with BEACOPP

Ron Daniel Jachimowicz, Luise Pieper, Sarah Reinke, Artur Gontarewicz, Annette Plütschow, Heinz Haverkamp, Leonie Frauenfeld, Falko Fend, Mathis Overkamp, Franziska Jochims, Christoph Thorns, Martin Leo Hansmann, Peter Möller, Andreas Rosenwald, Harald Stein, Hans Christian Reinhardt, Peter Borchmann, Bastian von Tresckow, Andreas Engert, Wolfram Klapper

Articles

CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T-cells

Marika Guercio, Domenico Orlando, Stefano Di Cecca, Matilde Sinibaldi, Iolanda Boffa, Simona Caruso, Zeinab Abbaszadeh, Antonio Camera, Biancamaria Cembrola, Katia Bovetti, Simona Manni, Ignazio Caruana, Roselia Ciccone, Francesca Del Bufalo, Pietro Merli, Luciana Vinti, Katia Girardi, Annalisa Ruggeri, Cristiano De Stefanis, Marco Pezzullo, Ezio Giorda, Marco Scarsella, Rita De Vito, Sabina Barresi, Andrea Ciolfi, Marco Tartaglia, Lorenzo Moretta, Franco Locatelli, Concetta Quintarelli, Biagio De Angelis

Articles

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers

Thomas Lewis, David B. Corcoran, David E. Thurston, Peter J. Giles, Kevin Ashelford, Elisabeth J. Walsby, Christopher D. Fegan, Andrea G.S. Pepper, Khondaker Miraz Rahman, Chris Pepper

Letters to the Editor

Donor cell leukemia: reappearance of gene mutations in donor cells - more than an incidental phenomenon?

Tal Shahar Gabay, Noa Chapal-Ilani, Yoni Moskovitz, Tamir Biezuner, Barak Oron, Yardena Brilon, Anna Fridman-Dror, Rawan Sabah, Ran Balicer, Amos Tanay, Netta Mendelson-Cohen, Eldad J. Dann, Riva Fineman, Nathali Kaushansky, Shlomit Yehudai-Reshef, Tsila Zuckerman, Liran I. Shlush

Letters to the Editor

The clinical and biological characteristics of NUP98-KDM5A in pediatric acute myeloid leukemia

Sanne Noort, Priscilla Wander, Todd A. Alonzo, Jenny Smith, Rhonda E. Ries, Robert B. Gerbing, M. Emmy M. Dolman, Franco Locatelli, Dirk Reinhardt, Andre Baruchel, Jan Stary, Jan J. Molenaar, Ronald W. Stam, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Soheil Meshinchi

Letters to the Editor

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

Zuzana Chyra, Tereza Sevcikova, Petr Vojta, Janka Puterova, Lucie Brozova, Katerina Growkova, Jana Filipova, Martina Zatopkova, Sebastian Grosicki, Agnieszka Barchnicka, Wieslaw Wiktor Jedrzejczak, Anna Waszczuk-Gajda, Alexandra Jungova, Aneta Mikulasova, Marian Hajduch, Martin Mokrejs, Ludek Pour, Martin Stork, Lubica Harvanova, Martin Mistrik, Gabor Mikala, Pawel Robak, Anna Czyz, Jakub Debski, Lidia Usnarska-Zubkiewicz, Artur Jurczyszyn, Lukas Stejskal, Gareth Morgan, Fedor Kryukov, Eva Budinska, Michal Simicek, Tomas Jelinek, Matous Hrdinka, Roman Hajek

Letters to the Editor

Clinical activity of abemaciclib in patients with relapsed or refractory mantle cell lymphoma - a phase II study

Franck Morschhauser, Kamal Bouabdallah, Stephan Stilgenbauer, Catherine Thieblemont, Sophie de Guibert, Florian Zettl, Lawrence M. Gelbert, P. Kellie Turner, Siva Rama Prasad Kambhampati, Li Li, Lily Q. Li, Sean Buchanan, Susana Barriga, Melissa M. Bear, Martin Wilhelm, Georg Hess

Letters to the Editor

Acute myeloid leukemia shapes the bone marrow stromal niche in vivo

Alice Pievani, Samantha Donsante, Chiara Tomasoni, Alessandro Corsi, Francesco Dazzi, Andrea Biondi, Mara Riminucci, Marta Serafini

Articles

Subcutaneous daratumumab in patients with relapsed or refractory multiple myeloma: Part 2 of the open-label, multicenter, dose-escalation phase 1b study (PAVO)

Jesus San-Miguel, Saad Z. Usmani, Maria-Victoria Mateos, Niels W.C.J. van de Donk, Jonathan L. Kaufman, Philippe Moreau, Albert Oriol, Torben Plesner, Lotfi Benboubker, Kevin Liu, Peter Hellemans, Tara Masterson, Pamela L. Clemens, Man Luo, Andrew Farnsworth, Hareth Nahi, Ajai Chari

Articles

Post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prevention in haploidentical transplantation for adult acute lymphoblastic leukemia

Arnon Nagler, Abraham S. Kanate, Myriam Labopin, Fabio Ciceri, Emanuele Angelucci, Yener Koc, Zafer Gülbas, William Arcese, Johanna Tischer, Pietro Pioltelli, Hakan Ozdogu, Boris Afanasyev, Depei Wu, Mutlu Arat, Zinaida Peric, Sebastian Giebel, Bipin Savani, Mohamad Mohty

Articles

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice

Sara Fañanas-Baquero, Israel Orman, Federico Becerra Aparicio, Silvia Bermudez de Miguel, Jordi Garcia Merino, Rosa Yañez, Yolanda Fernandez Sainz, Rebeca Sánchez, Mercedes Dessy-Rodríguez, Omaira Alberquilla, David Alfaro, Agustin Zapata, Juan A. Bueren, Jose Carlos Segovia, Oscar Quintana-Bustamante

Articles

Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk

Rhodri J. King, Katharina Schuett, Christian Tiede, Vera Jankowski, Vicky John, Abhi Trehan, Katie Simmons, Sreenivasan Ponnambalam, Robert F. Storey, Colin W.G. Fishwick, Michael J. McPherson, Darren C. Tomlinson, Ramzi A. Ajjan

Letters to the Editor

Chemoimmunotherapy with rituximab, cyclophosphamide and prednisolone in IgM paraproteinaemic neuropathy: evidence of sustained improvement in electrophysiological, serological and functional outcomes.

Nancy T.H. Colchester, David Allen, Haider A. Katifi, Tracy Burt, Robert N. Lown, Ashwin A. Pinto, Andrew S. Duncombe

Letters to the Editor

Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2

Joshua H. Bourne, Martina Colicchia, Ying Di, Eleyna Martin, Alexander Slater, Lubka T. Roumenina, Jordan D. Dimitrov, Steve P. Watson, Julie Rayes

Letters to the Editor

Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation

Yoko Nishinaka-Arai, Akira Niwa, Shiori Matsuo, Yasuhiro Kazuki, Yuwna Yakura, Takehiko Hiroma, Tsutomu Toki, Tetsushi Sakuma, Takashi Yamamoto, Etsuro Ito, Mitsuo Oshimura, Tatsutoshi Nakahata, Megumu K. Saito

Letters to the Editor

FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression

Man-Hua Liu, Jing Chen, Yun-Sheng Yang, Yin-Qi Wang, Guo-Qiang Chen, Yu Zhang, Ying Huang

Letters to the Editor

Efficacy of recombinant erythropoietin in autoimmune haemolytic anaemia: a multicentre international study

Bruno Fattizzo, Marc Michel, Anna Zaninoni, Juri Giannotta, Stephanie Guillet, Henrik Frederiksen, Josephine M.I. Vos, Francesca R. Mauro, Bernd Jilma, Andrea Patriarca, Francesco Zaja, Anita Hill, Sigbiørn Berentsen, Wilma Barcellini

Articles

Immune reconstitution and associated infections following axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma

Jennifer M. Logue, Elisa Zucchetti, Christina A. Bachmeier, Gabriel S. Krivenko, Victoria Larson, Daniel Ninh, Giovanni Grillo, Biwei Cao, Jongphil Kim, Julio C. Chavez, Aliyah Baluch, Farhad Khimani, Aleksandr Lazaryan, Taiga Nishihori, Hien D. Liu, Javier Pinilla-Ibarz, Bijal D. Shah, Rawan Faramand, Anna E. Coghill, Marco L. Davila, Bhagirathbhai R. Dholaria, Michael D. Jain, Frederick L. Locke

Articles

Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target

Hugo Larose, Nina Prokoph, Jamie D. Matthews, Michaela Schlederer, Sandra Högler, Ali F. Alsulami, Stephen P. Ducray, Edem Nuglozeh, Feroze M.S. Fazaludeen, Ahmed Elmouna, Monica Ceccon, Luca Mologni, Carlo Gambacorti-Passerini, Gerald Hoefler, Cosimo Lobello, Sarka Pospisilova, Andrea Janikova, Wilhelm Woessmann, Christine Damm-Welk, Martin Zimmermann, Alina Federova, Andrea Malone, Owen Smith, Mariusz Wasik, Giorgio Inghirami, Laurence Lamant, Tom L. Blundell, Wolfram Klapper, Olaf Merkel, G.A. Amos Burke, Shahid Mian, Ibraheem Ashankyty, Lukas Kenner, Suzanne D. Turner

Articles

Individualized dosing guidelines for PEGasparaginase and factors influencing the clearance: a population pharmacokinetic model

Robin Q.H. Kloos, Ron Mathôt, Rob Pieters, Inge M. van der Sluis

Articles

A zebrafish model for HAX1-associated congenital neutropenia

Larissa Doll, Narges Aghaallaei, Advaita M. Dick, Karl Welte, Julia Skokowa, Baubak Bajoghli

Articles

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification

Mania Ackermann, Kathrin Haake, Henning Kempf, Paul Kaschutnig, Anna-Carina Weiss, Ariane H.H. Nguyen, Markus Abeln, Sylvia Merkert, Mark Phillip Kühnel, Dorothee Hartmann, Danny Jonigk, Thomas Thum, Andreas Kispert, Michael D. Milsom, Nico Lachmann

Articles

Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells

Ismael Boussaid, Salomé Le Goff, Célia Floquet, Emilie-Fleur Gautier, Anna Raimbault, Pierre-Julien Viailly, Dina Al Dulaimi, Barbara Burroni, Isabelle Dusanter-Fourt, Isabelle Hatin, Patrick Mayeux, Bertrand Cosson, Michaela Fontenay

Articles

Factor VIII activity and bleeding risk during prophylaxis for severe hemophilia A: a population pharmacokinetic model

Andreas Tiede, Faraizah Abdul Karim, Victor Jiménez-Yuste, Robert Klamroth, Sandra Lejniece, Takashi Suzuki, Andreas Groth, Elena Santagostino

Articles

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation

Alicia Bornert, Julie Boscher, Fabien Pertuy, Anita Eckly, David Stegner, Catherine Strassel, Christian Gachet, François Lanza, Catherine Léon

Articles

Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver

Xiaolin Ma, Yun Li, Yuji Kondo, Huiping Shi, Jingjing Han, Yizhi Jiang, Xia Bai, Stephanie A. Archer-Hartmann, Parastoo Azadi, Changgeng Ruan, Jianxin Fu, Lijun Xia, Jiangsu Institute of Hematology, Soochow University, China

Articles

RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks

Sophie G. Kellaway, Peter Keane, Ella Kennett, Constanze Bonifer

Articles

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

Melissa V Chan, Melissa A Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E Allan, Matthew L Edin, Darryl C Zeldin, Ginger L Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B O'Donnell, Liang Dong, Michael G Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H Ouwehand, Ernest Turro, NIHR BioResource, Daniel P Hart, Kathleen Freson, Michael A Laffan, Timothy D Warner

Articles

Targeting of the A2A adenosine receptor counteracts immunosuppression in vivo in a mouse model of chronic lymphocytic leukemia

Francesca Arruga, Sara Serra, Nicoletta Vitale, Giulia Guerra, Andrea Papait, Benjamin Baffour Gyau, Francesco Tito, Dimitar Efremov, Tiziana Vaisitti, Silvia Deaglio

Articles

Second malignancies after treatment of childhood non-Hodgkin lymphoma: a report of the Berlin-Frankfurt-Muenster study group

Olga Moser, Martin Zimmermann, Ulrike Meyer, Wolfram Klapper, Ilske Oschlies, Martin Schrappe, Andishe Attarbaschi, Georg Mann, Felix Niggli, Claudia Spix, Udo Kontny, Thomas Klingebiel, Alfred Reiter, Birgit Burkhardt, Wilhelm Woessmann

Letters to the Editor

miR-939 acts as tumor suppressor by modulating JUNB transcriptional activity in pediatric anaplastic large cell lymphoma

Anna Garbin, Federica Lovisa, Antony B. Holmes, Carlotta C. Damanti, Ilaria Gallingani, Elisa Carraro, Benedetta Accordi, Giulia Veltri, Marco Pizzi, Emanuele S.G. d'Amore, Marta Pillon, Alessandra Biffi, Katia Basso, Lara Mussolin

Letters to the Editor

Myeloid/lymphoid neoplasms with eosinophilia/ basophilia and ETV6-ABL1 fusion: cell-of-origin and response to tyrosine kinase inhibition

JinJuan Yao, Lianrong Xu, Umut Aypar, Howard J. Meyerson, Dory Londono, Qi Gao, Jeeyeon Baik, James Dietz, Ryma Benayed, Allison Sigler, Mariko Yabe, Ahmet Dogan, Maria E. Arcila, Mikhail Roshal, Yanming Zhang, Michael J. Mauro, Wenbin Xiao

Letters to the Editor

SMAD1 promoter hypermethylation and lack of SMAD1 expression in Hodgkin lymphoma: a potential target for hypomethylating drug therapy

Magdalena M. Gerlach, Anna Stelling-Germani, Cheuk Ting Wu, Sebastian Newrzela, Claudia Döring, Visar Vela, Anne Müller, Sylvia Hartmann, Alexandar Tzankov

Letters to the Editor

Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia

Aoli Wang, Chen Hu, Cheng Chen, Xiaofei Liang, Beilei Wang, Fengming Zou, Kailin Yu, Feng Li, Qingwang Liu, Ziping Qi, Junjie Wang, Wenliang Wang, Li Wang, Ellen L. Weisberg, Wenchao Wang, Lili Li, Jian Ge, Ruixiang Xia, Jing Liu, Qingsong Liu

Articles

MYC rearrangement but not extra MYC copies is an independent prognostic factor in patients with mantle cell lymphoma

Lifu Wang, Guilin Tang, L. Jeffrey Medeiros, Jie Xu, Wenting Huang, C. Cameron Yin, Michael Wang, Preetesh Jain, Pei Lin, Shaoying Li

Articles

Genetic lesions in MYC and STAT3 drive oncogenic transcription factor overexpression in plasmablastic lymphoma.

Julia Garcia-Reyero, Nerea Martinez Magunacelaya, Sonia Gonzalez de Villambrosia, Sanam Loghavi, Angela Gomez Mediavilla, Raul Tonda, Sergi Beltran, Marta Gut, Ainara Pereña Gonzalez, Emanuele d' Ámore, Carlo Visco, Joseph D. Khoury, Santiago Montes-Moreno

Articles

Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study

Lesley-Ann Sutton, Viktor Ljungström, Anna Enjuanes, Diego Cortese, Aron Skaftason, Eugen Tausch, Katerina Stano Kozubik, Ferran Nadeu, Marine Armand, Jikta Malcikova, Tatjana Pandzic, Jade Forster, Zadie Davis, David Oscier, Davide Rossi, Paolo Ghia, Jonathan C. Strefford, Sarka Pospisilova, Stephan Stilgenbauer, Frederic Davi, Elias Campo, Kostas Stamatopoulos, Richard Rosenquist, European Research Initiative on CLL (ERIC)

Articles

Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study

Marie José Kersten, Julia Driessen, Josée M. Zijlstra, Wouter J. Plattel, Franck Morschhauser, Pieternella J. Lugtenburg, Pauline Brice, Martin Hutchings, Thomas Gastinne, Roberto Liu, Coreline N. Burggraaff, Marcel Nijland, Sanne H. Tonino, Anne I. J. Arens, Roelf Valkema, Harm van Tinteren, Marta Lopez-Yurda, Arjan Diepstra, Daphne De Jong, Anton Hagenbeek

Articles

TAK1 is a pivotal therapeutic target for tumor progression and bone destruction in myeloma

Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Asuka Oda, Ariunzaya Bat-Erdene, Takeshi Harada, Shingen Nakamura, Mohannad Ashtar, So Shimizu, Masami Iwasa, Kimiko Sogabe, Masahiro Oura, Shiro Fujii, Kumiko Kagawa, Hirokazu Miki, Itsuro Endo, Tatsuji Haneji, Toshio Matsumoto, Masahiro Abe

Case Reports

Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia

Barbara Schmaltz-Panneau, Anne Pagnier, Séverine Clauin, Julien Buratti, Caroline Marty, Odile Fenneteau, Klaus Dieterich, Blandine Beaupain, Jean Donadieu, Isabelle Plo, Christine Bellanné-Chantelot

Articles

Endothelial injury, F-actin and vitamin-D binding protein after hematopoietic stem cell transplant and association with clinical outcomes

Nathan Luebbering, Sheyar Abdullah, Dana Lounder, Adam Lane, Nikhil Dole, Jeremy Rubinstein, Martin Hewison, Nicholas Gloude, Sonata Jodele, Kitty M.R. Perentesis, Kelly Lake, Bridget Litts, Alexandra Duell, Christopher E. Dandoy, Stella M. Davies

Articles

Genome editing of donor-derived T-cells to generate allogenic chimeric antigen receptor-modified T cells: Optimizing αβ T cell-depleted haploidentical hematopoietic stem cell transplantation

Volker Wiebking, Ciaran M. Lee, Nathalie Mostrel, Premanjali Lahiri, Rasmus Bak, Gang Bao, Maria Grazia Roncarolo, Alice Bertaina, Matthew H. Porteus

Articles

Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity

Angelo D'Alessandro, Xiaoyun Fu, Tamir Kanias, Julie A. Reisz, Rachel Culp-Hill, Yuelong Guo, Mark T. Gladwin, Grier Page, Steven Kleinman, Marion Lanteri, Mars Stone, Michael P. Busch, James C. Zimring, Recipient Epidemiology and Donor Evaluation Study-III (REDS III)

Articles

Diagnosis and prognosis are comforted by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study.

Sophie Vantyghem, Pierre Peterlin, Sylvain Thépot, Audrey Ménard, Viviane Dubruille, Camille Debord, Thierry Guillaume, Alice Garnier, Amandine Le Bourgeois, Soraya Wuilleme, Catherine Godon, Olivier Theisen, Marion Eveillard, Jacques Delaunay, Hervé Maisonneuve, Nadine Morineau, Bruno Villemagne, Stéphane Vigouroux, François Subiger, Elsa Lestang, Marion Loirat, Anne Parcelier, Pascal Godmer, Mélanie Mercier, Adrien Trebouet, Damien Luque Paz, Ronan Le Calloch, Lenaig Le Clech, Céline Bossard, Anne Moreau, Valérie Ugo, Mathilde Hunault, Philippe Moreau, Steven Le Gouill, Patrice Chevallier, Marie C. Béné, Yannick Le Bris

Articles

Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia

Anuhar Chaturvedi, Charu Gupta, Razif Gabdoulline, Nora M. Borchert, Ramya Goparaju, Stefan Kaulfuss, Kerstin Görlich, Renate Schottmann, Basem Othman, Julia Welzenbach, Olaf Panknin, Markus Wagner, Robert Geffers, Arnold Ganser, Felicitas Thol, Michael Jeffers, Andrea Haegebarth, Michael Heuser

Articles

Genotype-phenotype association and variant characterization in Diamond-Blackfan anemia caused by pathogenic variants in RPL35A

D. Matthew Gianferante, Marcin W. Wlodarski, Evangelia Atsidaftos, Lydie Da Costa, Polyxeni Delaporta, Jason E. Farrar, Frederick D. Goldman, Maryam Hussain, Antonis Kattamis, Thierry Leblanc, Jeffrey M. Lipton, Charlotte M. Niemeyer, Dagmar Pospisilova, Paola Quarello, Ugo Ramenghi, Vijay G. Sankaran, Adrianna Vlachos, Jana Volejnikova, Blanche P. Alter, Sharon A. Savage, Neelam Giri

Articles

Immunophenotypic characterization of reactive and neoplastic plasmacytoid dendritic cells permits establishment of a 10-color flow cytometric panel for initial workup and residual disease evaluation of blastic plasmacytoid dendritic cell neoplasm

Wei Wang, Joseph D. Khoury, Roberto N. Miranda, Jeffrey L. Jorgensen, Jie Xu, Sanam Loghavi, Shaoying Li, Naveen Pemmaraju, Than Nguyen, L. Jeffrey Medeiros, Sa A. Wang

Letters to the Editor

Primary therapy and survival in patients aged over 70-years-old with primary central nervous system lymphoma: a contemporary, nationwide, population-based study in the Netherlands

Matthijs van der Meulen, Jacoline E.C. Bromberg, Marcel Nijland, Otto Visser, Jeanette K. Doorduijn, Avinash G. Dinmohamed

Letters to the Editor

Validated single-tube multiparameter flow cytometry approach for the assessment of minimal residual disease in multiple myeloma

Sandra Maria Dold, Veronika Riebl, Dagmar Wider, Marie Follo, Milena Pantic, Gabriele Ihorst, Justus Duyster, Robert Zeiser, Ralph Wäsch, Monika Engelhardt

Articles

Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport

Ellie Karampini, Petra E. Bürgisser, Jenny Olins, Aat A. Mulder, Carolina R. Jost, Dirk Geerts, Jan Voorberg, Ruben Bierings

Articles

Stem cell factor Is implicated In microenvironmental interactions and cellular dynamics of chronic lymphocytic leukemia

George I. Gavriilidis, Stavroula Ntoufa, Nikos Papakonstantinou, Konstantia Kotta, Triantafyllia Koletsa, Elisavet Chartomatsidou, Theodoros Moysiadis, Niki Stavroyianni, Achilles Anagnostopoulos, Eleni Papadaki, Asterios S. Tsiftsoglou, Kostas Stamatopoulos

Letters to the Editor

FcγRIIb-BCR co-ligation inhibits BCR signaling in chronic lymphocytic leukemia

Rosa Bosch, Alba Mora, Carolina Cuellar, Gerardo Ferrer, Sergey Gorlatov, Josep Nomdedéu, Emili Montserrat, Jorge Sierra, Kanti R. Rai, Nicholas Chiorazzi, Carol Moreno

Letters to the Editor

Clinicopathological and genetic features of limited-stage diffuse large B-cell lymphoma with late relapse: targeted sequencing analysis of gene alterations in the initial and late relapsed tumors

Tomotaka Suzuki, Suguru Fukuhara, Junko Nomoto, Satoshi Yamashita, Akiko (Miyagi) Maeshima, Yuta Ito, Shunsuke Hatta, Sayako Yuda, Shinichi Makita, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Hirokazu Taniguchi, Toshikazu Ushijima, Koji Izutsu, Kensei Tobinai, Yukio Kobayashi

Letters to the Editor

The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway

Patricia Hermand, Slim Azouzi, Emilie-Fleur Gautier, François Guillonneau, Vincent Bondet, Darragh Duffy, Sebastien Dechavanne, Pierre-Louis Tharaux, Patrick Mayeux, Caroline Le Van Kim, Berengere Koehl

Articles

Genomic alterations in patients with somatic loss of the Y chromosome as the sole cytogenetic finding in bone marrow cells

Madhu M. Ouseph, Robert P. Hasserjian, Paola Dal Cin, Scott B. Lovitch, David P. Steensma, Valentina Nardi, Olga K. Weinberg

Articles

The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma.

Manuel Montesinos-Rongen, Monica Terrao, Caroline May, Katrin Marcus, Ingmar Blümcke, Martin Hellmich, Ralf Küppers, Anna Brunn, Martina Deckert

Articles

C-FGF23 peptide alleviates hypoferremia during acute inflammation

Rafiou Agoro, Min Young Park, Carole Le Henaff, Stanislovas Jankauskas, Alina Gaias, Gaozhi Chen, Moosa Mohammadi, Despina Sitara

Letters to the Editor

Daratumumab inhibits acute myeloid leukaemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells

Jayna J Mistry, Jamie A Moore, Prakritt Kumar, Christopher R Marlein, Charlotte Hellmich, Genevra Pillinger, Aisha Jibril, Federica Di Palma, Angela Collins, Kristian M Bowles, Stuart A. Rushworth

Articles

The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia

Xinyu Li, Yongwei Su, Katie Hege, Gerard Madlambayan, Holly Edwards, Tristan Knight, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jay Yang, Regan Miller, Guan Wang, Lijing Zhao, Yue Wang, Hai Lin, Jeffrey W. Taub, Yubin Ge

Articles

P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3

Wenli Feng, Xiao Yang, Lina Wang, Rong Wang, Feifei Yang, Hao Wang, Xiaoli Liu, Qian Ren, Yingchi Zhang, Xiaofan Zhu, Guoguang Zheng

Letters to the Editor

Low incidence of EPOR mutations in idiopathic erythrocytosis

Mathilde Filser, Bernard Aral, Fabrice Airaud, Aurélie Chauveau, Aisha Bruce, Yann Polfrit, Anne Thiebaut, Martin Gauthier, Cédric Le Maréchal, Eric Lippert, Stéphane Béziau, Céline Garrec, Betty Gardie, François Girodon

Letters to the Editor

CD4+ T-cell alloreactivity after haploidentical hematopoietic stem cell transplantation

Burak Kalin, Elisabetta Metafuni, Mariëtte ter Borg, Rebecca Wijers, Eric Braakman, Cor H.J. Lamers, Andrea Bacigalupo, Jan J. Cornelissen

Articles

Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia

Yuzhe Shi, Melanie C. Beckett, Helen J. Blair, Ricky Tirtakusuma, Sirintra Nakjang, Amir Enshaei, Christina Halsey, Josef Vormoor, Olaf Heidenreich, Anja Krippner-Heidenreich, Frederik W. van Delft

Articles

Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice

Bola S. Hanna, Haniyeh Yazdanparast, Yasmin Demerdash, Philipp M. Roessner, Ralph Schulz, Peter Lichter, Stephan Stilgenbauer, Martina Seiffert

Articles

Bendamustine, followed by ofatumumab and ibrutinib in chronic lymphocytic leukemia (CLL2-BIO): primary endpoint analysis of a multicentre, open-label phase-II trial

Paula Cramer, Julia v. Tresckow, Sandra Robrecht, Jasmin Bahlo, Moritz Fürstenau, Petra Langerbeins, Natali Pflug, Othman Al-Sawaf, Werner J. Heinz, Ursula Vehling-Kaiser, Jan Dürig, Eugen Tausch, Manfred Hensel, Stephanie Sasse, Anna-Maria Fink, Kirsten Fischer, Karl-Anton Kreuzer, Sebastian Böttcher, Matthias Ritgen, Michael Kneba, Clemens-Martin Wendtner, Stephan Stilgenbauer, Barbara Eichhorst, Michael Hallek

Articles

Response-adapted therapy with infusional EPOCH chemotherapy plus rituximab in HIV- associated, B-cell non-Hodgkin's lymphoma

Joseph A. Sparano, Jeannette Y. Lee, Lawrence D. Kaplan, Juan Carlos Ramos, Richard F. Ambinder, William Wachsman, David Aboulafia, Ariela Noy, David H. Henry, Lee Ratner, Ethel Cesarman, Amy Chadburn, Ronald Mitsuyasu

Articles

The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene

Cristina Fugazza, Gloria Barbarani, Sudharshan Elangovan, Maria Giuseppina Marini, Serena Giolitto, Isaura Font-Monclus, Maria Franca Marongiu, Laura Manunza, John Strouboulis, Claudio Cantù, Fabio Gasparri, Silvia M.L. Barabino, Yukio Nakamura, Sergio Ottolenghi, Paolo Moi, Antonella Ellena Ronchi

Articles

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice

Antonella Nai, Maria Rosa Lidonnici, Giorgia Federico, Mariateresa Pettinato, Violante Olivari, Federica Carrillo, Simonetta Geninatti Crich, Giuliana Ferrari, Clara Camaschella, Laura Silvestri, Francesca Carlomagno

Articles

The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice

Frederik Denorme, Kimberly Martinod, Aline Vandenbulcke, Cécile V. Denis, Peter J. Lenting, Hans Deckmyn, Karen Vanhoorelbeke, Simon F. De Meyer

Articles

Carfilzomib, cyclophosphamide and dexamethasone for newly diagnosed, high-risk myeloma patients not eligible for transplant: a pooled analysis of two studies

Roberto Mina, Francesca Bonello, Maria Teresa Petrucci, Anna Marina Liberati, Concetta Conticello, Stelvio Ballanti, Pellegrino Musto, Attilio Olivieri, Giulia Benevolo, Andrea Capra, Milena Gilestro, Piero Galieni, Michele Cavo, Agostina Siniscalchi, Antonio Palumbo, Vittorio Montefusco, Gianluca Gaidano, Paola Omedé, Mario Boccadoro, Sara Bringhen

Letters to the Editor

Elotuzumab, lenalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: Italian, multicenter, retrospective clinical experience with 300 cases outside of controlled clinical trials

Massimo Gentile, Giorgina Specchia, Daniele Derudas, Monica Galli, Cirino Botta, Stefano Rocco, Concetta Conticello, Catello Califano, Nicola Giuliani, Silvia Mangiacavalli, Enrico Attingenti, Alessandra Lombardo, Marino Brunori, Elena Rossi, Elisabetta Antonioli, Roberto Ria, Renato Zambello, Nicola Di Renzo, Giuseppe Mele, Gianpaolo Marcacci, Pellegrino Musto, Silvana Capalbo, Nicola Cascavilla, Claudio Cerchione, Angelo Belotti, Clelia Criscuolo, Giuseppina Uccello, Paola Curci, Ernesto Vigna, Vincenzo Fraticelli, Donatella Vincelli, Angela Bonalumi, Agostina Siniscalchi, Raffaella Stocchi, Massimo Martino, Stelvio Ballanti, Dominella Gangemi, Alfredo Gagliardi, Barbara Gamberi, Alessandra Pompa, Anna Grazia Recchia, Giovanni Tripepi, Annalisa Pitino, Ferdinando Frigeri, Ugo Consoli, Sara Bringhen, Elena Zamagni, Francesca Patriarca, Valerio De Stefano, Francesco Di Raimondo, Salvatore Palmieri, Maria Teresa Petrucci, Massimo Offidani, Mario Boccadoro, Michele Cavo, Fortunato Morabito

Letters to the Editor

Wip1 regulates hematopoietic stem cell development in the mouse embryo

Wenyan He, Xiaobo Wang, Yanli Ni, Zongcheng Li, Wei Liu, Zhilin Chang, Haowen Li, Zhenyu Ju, Zhuan Li

Letters to the Editor

Chronic lymphocytic leukemias with trisomy 12 show a distinct DNA methylation profile linked to altered chromatin activation

Maria Tsagiopoulou, Vicente Chapaprieta, Martí Duran-Ferrer, Theodoros Moysiadis, Fotis Psomopoulos, Panagoula Kollia, Nikos Papakonstantinou, Elias Campo, Kostas Stamatopoulos, Jose I. Martin-Subero

Letters to the Editor

High bias and low precision for estimated versus measured glomerular filtration rate in pediatric sickle cell anemia

Jeffrey D. Lebensburger, Jeffrey Gossett, Rima Zahr, Winfred C. Wang, Kenneth I. Ataga, Jeremie H. Estepp, Guolian Kang, Jane S. Hankins

Letters to the Editor

Platelets from patients with myocardial infarction can activate T cells

Elena E. Solomou, Katerina Katsanaki, Elena Kalyvioti, Vasilios Gizas, Angelos Perperis, Dora Babali, Evgenia Verigou, Haralambos Gogos, George Hahalis, Periklis Davlouros, Dimitrios Alexopoulos

Letters to the Editor

Decolonization of multi-drug resistant bacteria by fecal microbiota transplantation in five pediatric patients before allogeneic hematopoietic stem cell transplantation: gut microbiota profiling, infectious and clinical outcomes.

Pietro Merli, Lorenza Putignani, Annalisa Ruggeri, Federica Del Chierico, Livia Gargiullo, Federica Galaverna, Stefania Gaspari, Daria Pagliara, Alessandra Russo, Stefania Pane, Luisa Strocchio, Mattia Algeri, Francesca Rea, Erminia Francesca Romeo, Paola Bernaschi, Andrea Onetti Muda, Bruno Dallapiccola, Franco Locatelli

Letters to the Editor

FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia

Peter A. A. Norris, George B. Segel, W. Richard Burack, Ulrich J. Sachs, Suzanne N. Lissenberg-Thunnissen, Gestur Vidarsson, Behnaz Bayat, Christine M. Cserti-Gazdewich, Jeannie Callum, Yulia Lin, Donald Branch, Rick Kapur, John W. Semple, Alan H. Lazarus

Letters to the Editor

Impact of graft composition on outcomes of haploidentical bone marrow stem cell transplantation

Rima M. Saliba, Lauren Veltri, Gabriela Rondon, Julianne Chen, Gheath Al-Atrash, Amin Alousi, Charles Martinez, LaJerald Augustine, Chitra M. Hosing, Betul Oran, Katayoun Rezvani, Elisabeth J. Shpall, Partow Kebriaei, Issa F. Khouri, Uday Popat, Richard E. Champlin, Stefan O. Ciurea

Articles

Targeted genotyping of circulating tumor DNA for classical Hodgkin Lymphoma monitoring: a prospective study

Vincent Camus, Mathieu Viennot, Justine Lequesne, Pierre-Julien Viailly, Elodie Bohers, Lucile Bessi, Bénédicte Marcq, Pascaline Etancelin, Sydney Dubois, Jean-Michel Picquenot, Elena-Liana Veresezan, Marie Cornic, Lucie Burel, Justine Loret, Stéphanie Becker, Pierre Decazes, Pascal Lenain, Stéphane Lepretre, Emilie Lemasle, Hélène Lanic, Anne-Lise Ménard, Nathalie Contentin, Hervé Tilly, Aspasia Stamatoullas, Fabrice Jardin

Articles

G-CSF directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells

Miner Xie, Shanshan Zhang, Fang Dong, Qingyun Zhang, Jinhong Wang, Chenchen Wang, Caiying Zhu, Sen Zhang, Bingqing Luo, Peng Wu, Hideo Ema

Articles

Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia

Xin Li, Zi Sheng, Yuanxin Sun, Yuanjian Wang, Miao Xu, Zhiyue Zhang, Hui Li, Linlin Shao, Yanqi Zhang, Jinming Yu, Chunhong Ma, Chengjiang Gao, Ming Hou, Heyu Ni, Jun Peng, Ji Ma, Qi Feng

Articles

Iron deficiency induced thrombocytosis increases thrombotic tendency in rats

Kristine Jimenez, Florentina Leitner, Aran Leitner, Gisela Scharbert, Philipp Schwabl, Anne-Margarethe Kramer, Anita Krnjic, Joachim Friske, Thomas Helbich, Rayko Evstatiev, Vineeta Khare, Christoph Gasche

Articles

Identification of an immunogenic DKK1 long peptide for immunotherapy of human multiple myeloma

Rong Li, Chengyun Zheng, Qiang Wang, Enguang Bi, Maojie Yang, Jian Hou, Weijun Fu, Qing Yi, Jianfei Qian

Articles

Cell free circulating tumor DNA in cerebrospinal fluid detects and monitors central nervous system involvement of B-cell lymphomas

Sabela Bobillo, Marta Crespo, Laura Escudero, Regina Mayor, Priyanka Raheja, Cecilia Carpio, Carlota Rubio-Perez, Bárbara Tazón-Vega, Carlos Palacio, Júlia Carabia, Isabel Jiménez, Juan C. Nieto, Julia Montoro, Francisco Martínez-Ricarte, Josep Castellvi, Marc Simó, Lluis Puigdefàbregas, Pau Abrisqueta, Francesc Bosch, Joan Seoane

Articles

Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma

Daniele Caracciolo, Francesca Scionti, Giada Juli, Emanuela Altomare, Gaetanina Golino, Katia Todoerti, Katia Grillone, Caterina Riillo, Mariamena Arbitrio, Michelangelo Iannone, Eugenio Morelli, Nicola Amodio, Maria Teresa Di Martino, Marco Rossi, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone

Articles

Differential RNA splicing as a potentially important driver mechanism in multiple myeloma

Michael A. Bauer, Cody Ashby, Christopher Wardell, Eileen M. Boyle, Maria Ortiz, Erin Flynt, Anjan Thakurta, Gareth Morgan, Brian A. Walker

Articles

Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma

Matias Autio, Suvi-Katri Leivonen, Oscar Brück, Satu Mustjoki, Judit Mészáros Jørgensen, Marja-Liisa Karjalainen-Lindsberg, Klaus Beiske, Harald Holte, Teijo Pellinen, Sirpa Leppä

Letters to the Editor

Exome sequencing reveals heterogeneous clonal dynamics in donor cell myeloid neoplasms after stem cell transplantation

Julia Suárez-González, Juan Carlos Triviño, Guiomar Bautista, José Antonio García-Marco, Ángela Figuera, Antonio Balas, José Luis Vicario, Francisco José Ortuño, Raúl Teruel, José María Álamo, Diego Carbonell, Cristina Andrés-Zayas, Nieves Dorado, Gabriela Rodríguez-Macías, Mi Kwon, José Luis Díez-Martín, Carolina Martínez-Laperche, Ismael Buño, Spanish Group for Hematopoietic Transplantation (GETH)

Letters to the Editor

Macrophage-HFE controls iron metabolism and immune responses in aged mice

Naveen Kumar Tangudu, Dilay Yilmaz, Katharina Wörle, Andreas Gruber, Silvia Colucci, Kerstin Leopold, Martina U. Muckenthaler, Maja Vujic Spasic

Letters to the Editor

Factor IX alteration p.Arg338Gln (FIX Shanghai) potentiates FIX clotting activity and causes thrombosis

Wenman Wu, Lin Xiao, Xi Wu, Xiaoling Xie, Ping Li, Changming Chen, Zhaoyue Zheng, Jiangang Ai, Alexander Valencia, Birong Dong, Qiulan Ding, Biao Dong, Xuefeng Wang

Letters to the Editor

Comparative analysis of targeted novel therapies in relapsed, refractory chronic lymphocytic leukaemia

Toby A. Eyre, Nicole Lamanna, Lindsey E. Roeker, Chaitra S. Ujjani, Brian T. Hill, Paul M. Barr, Erick Lansigan, Bruce D. Cheson, Maryam Yazdy, John N. Allan, Joanna Rhodes, Stephen J. Schuster, Chadi Nabhan, Alan Skarbnik, Lori Leslie, Prioty Islam, Katherine Whitaker, Catherine C. Coombs, Hande H. Tuncer, John M. Pagel, Ryan Jacobs, Allison M. Winter, Neil Bailey, Andrea Sitlinger, Anna H. Schuh, George Follows, Christopher P. Fox, Danielle M. Brander, Mazyar Shadman, Anthony R. Mato

Letters to the Editor

Impact and safety of chimeric antigen receptor T cell therapy in older, vulnerable patients with relapsed/refractory large b-cell lymphoma

Richard J. Lin, Stephanie M. Lobaugh, Martina Pennisi, Hei Ton Chan, Yakup Batlevi, Josel D. Ruiz, Theresa A. Elko, Molly A. Maloy, Connie L. Batlevi, Parastoo B. Dahi, Sergio A. Giralt, Paul A. Hamlin, Elena Mead, Arela Noy, M. Lia Palomba, Bianca D. Santomasso, Craig S. Sauter, Michael Scordo, Gunjan L. Shah, Beatriz Korc-Grodzicki, Soo Jung Kim, Mari Lynne Silverberg, Chelsea A. Brooklyn, Sean M. Devlin, Miguel-Angel Perales

Articles

Utility of clinical comprehensive genomic characterisation for diagnostic categorisation in patients presenting with hypocellular bone marrow failure syndromes

Piers Blombery, Lucy Fox, Georgina L. Ryland, Ella R. Thompson, Jennifer Lickiss, Michelle McBean, Satwica Yerneni, David Hughes, Anthea Greenway, Francoise Mechinaud, Erica M. Wood, Graham J. Lieschke, Jeff Szer, Pasquale Barbaro, John Roy, Joel Wight, Elly Lynch, Melissa Martyn, Clara Gaff, David Ritchie

Articles

Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma

Shingo Nakahata, Chilmi Syahrul, Ayako Nakatake, Kuniyo Sakamoto, Maki Yoshihama, Ichiro Nishikata, Yoshinori Ukai, Tadashi Matsuura, Takuro Kameda, Kotaro Shide, Yoko Kubuki, Tomonori Hidaka, Akira Kitanaka, Akihiko Ito, Shigeki Takemoto, Nobuaki Nakano, Masumichi Saito, Masako Iwanaga, Yasuko Sagara, Kosuke Mochida, Masahiro Amano, Kouichi Maeda, Eisaburo Sueoka, Akihiko Okayama, Atae Utsunomiya, Kazuya Shimoda, Toshiki Watanabe, Kazuhiro Morishita

Letters to the Editor

SIRPαFc treatment targets human acute myeloid leukemia stem cells.

Oleksandr Galkin, Jessica McLeod, James A. Kennedy, Liqing Jin, Nathan Mbong, Mark Wong, Robert A. Uger, Mark D. Minden, Jayne S. Danska, Jean C.Y. Wang

Letters to the Editor

Lenalidomide, dexamethasone and alemtuzumab or ofatumumab in high-risk chronic lymphocytic leukaemia: final results of the NCRI CLL210 trial

Andrew R. Pettitt, Richard Jackson, Silvia Cicconi, Fotis Polydoros, Christina Yap, James Dodd, Matthew Bickerstaff, Michael Stackpoole, Umair T. Khan, Stacey Carruthers, Melanie Oates, Ke Lin, Sarah E. Coupland, Geetha Menon, Nagesh Kalakonda, Helen McCarthy, Adrian Bloor, Anna Schuh, Andrew Duncombe, Claire Dearden, Christopher Fegan, Ben Kennedy, Renata Walewska, Scott Marshall, Christopher P. Fox, Peter Hillmen

Letters to the Editor

A 70% cut-off for MYC protein expression in diffuse large B cell lymphoma identifies a high-risk group of patients

Marita Ziepert, Stefano Lazzi, Raffaella Santi, Federica Vergoni, Massimo Granai, Virginia Mancini, Annette Staiger, Heike Horn, Markus Löffler, Viola Pöschel, Gerhald Held, Gerald Wulf, Lorenz H. Trümper, Norbert Schmitz, Andreas Rosenwald, Elena Sabattini, Kikkeri N. Naresh, Harald Stein, German Ott, Lorenzo Leoncini

Letters to the Editor

Peripheral neuropathy and monoclonal gammopathy of undetermined significance: a population-based study including 15,351 cases and 58,619 matched controls

Sæmundur Rögnvaldsson, Vilhjálmur Steingrímsson, Ingemar Turesson, Magnus Björkholm, Ola Landgren, Sigurður Yngvi Kristinsson

Letters to the Editor

NPAS4L is involved in avian hemangioblast specification

Wei Weng, Hiroki Nagai, Sofiane Hamidi, Guojun Sheng

Letters to the Editor

Efficacy of anti-PD1 re-treatment in patients with Hodgkin lymphoma who relapsed after anti-PD1 discontinuation

Guillaume Manson, Pauline Brice, Charles Herbaux, Kamal Bouabdallah, Chloé Antier, Florence Poizeau, Laurent Dercle, Roch Houot

Letters to the Editor

Ixazomib-Thalidomide-low dose dexamethasone induction followed by maintenance therapy with ixazomib or placebo in newly diagnosed multiple myeloma patients not eligible for autologous stem cell transplantation; results from the randomized phase II HOVON-126/NMSG 21.13 trial

Sonja Zweegman, Claudia A.M. Stege, Einar Haukas, Fredrik H. Schjesvold, Mark-David Levin, Anders Waage, Rineke B.L. Leys, Saskia K. Klein, Damian Szatkowski, Per Axelsson, Trung Hieu Do, Dorota Knut-Bojanowska, Ellen van der Spek, Asta Svirskaite, Anja Klostergaard, Morten Salomo, Celine Blimark, Paula F. Ypma, Ulf-Henrik Mellqvist, Pino J. Poddighe, Marian Stevens-Kroef, Niels W.C.J. van de Donk, Pieter Sonneveld, Markus Hansson, Bronno van der Holt, Niels Abildgaard

Letters to the Editor

Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2

Alessia Pagani, Mariateresa Pettinato, Silvia Colucci, Alessandro Dulja, Martina Rauner, Antonella Nai, Clara Camaschella, Sandro Altamura, Martina U. Muckenthaler, Laura Silvestri

Letters to the Editor

Safe and efficient peripheral blood stem cell collection in patients with sickle cell disease using plerixafor

Naoya Uchida, Alexis Leonard, David Stroncek, Sandhya R. Panch, Kamille West, Eoghan Molloy, Thomas E. Hughes, Sara Hauffe, Tiffani Taylor, Courtney Fitzhugh, Jane S. Hankins, Megan Wilson, Akshay Sharma, Shengdar Q. Tsai, Mitch J. Weiss, Matthew Hsieh, John F. Tisdale

Letters to the Editor

Brentuximab vedotin in the treatment of elderly Hodgkin lymphoma patients at first relapse or with primary refractory disease: a phase II study of FIL ONLUS

Vittorio Stefoni, Miriam Marangon, Alessandro Re, Arben Lleshi, Maurizio Bonfichi, Antonello Pinto, Nicola Bianchetti, Cinzia Pellegrini, Lisa Argnani, Pier Luigi Zinzani

Letters to the Editor

Impact of idelalisib on health-related quality of life in patients with relapsed chronic lymphocytic leukemia in a phase III randomized trial

Paolo Ghia, Steven E. Coutre, Bruce D. Cheson, Jacqueline C. Barrientos, Peter Hillmen, Andrew R. Pettitt, Andrew D. Zelenetz, Sanatan Shreay, Michael Hallek, Richard R. Furman

Articles

uPA-mediated plasminogen activation is enhanced by polyphosphate

Claire S Whyte, Nicola J Mutch

Articles

Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma

Aloke Sarkar, Christine M. Stellrecht, Hima V. Vangapandu, Mary Ayres, Benny A. Kaipparettu, Jun Hyoung Park, Kumudha Balakrishnan, Jared K. Burks, Tej K. Pandita, Walter N. Hittelman, Sattva S. Neelapu, Varsha Gandhi

Letters to the Editor

Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice

Sarah Ebinger, Christina Zeller, Michela Carlet, Daniela Senft, Johannes W. Bagnoli, Wen-Hsin Liu, Maja Rothenberg-Thurley, Wolfgang Enard, Klaus H. Metzeler, Tobias Herold, Karsten Spiekermann, Binje Vick, Irmela Jeremias

Articles

Accuracy of chitotriosidase activity and CCL18 concentration in assessing type I Gaucher disease severity. A systematic review with meta-analysis of individual participant data.

Tatiana Raskovalova, Patrick B. Deegan, Pramod K. Mistry, Elena Pavlova, Ruby Yang, Ari Zimran, Juliette Berger, Céline Bourgne, Bruno Pereira, José Labarère, Marc G. Berger

Articles

Outcomes after late bone marrow and very early central nervous system relapse of childhood B-Acute lymphoblastic leukemia: a report from the Children's Oncology Group phase III study AALL0433

Glen Lew, Yichen Chen, Xiaomin Lu, Susan R. Rheingold, James A. Whitlock, Meenakshi Devidas, Caroline A. Hastings, Naomi J. Winick, William L. Carroll, Brent L. Wood, Michael J. Borowitz, Michael A. Pulsipher, Stephen P. Hunger

Articles

The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission

Sandrine Jeanpierre, Kawtar Arizkane, Supat Thongjuea, Elodie Grockowiak, Kevin Geistlich, Lea Barral, Thibault Voeltzel, Anissa Guillemin, Sandrine Gonin-Giraud, Olivier Gandrillon, Franck-Emmanuel Nicolini, Adam J. Mead, Véronique Maguer-Satta, Sylvain Lefort

Articles

Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells

Takashi Yahata, Abd Aziz Ibrahim, Ken-ichi Hirano, Yukari Muguruma, Kazuhito Naka, Katsuto Hozumi, Douglas E. Vaughan, Toshio Miyata, Kiyoshi Ando

Letters to the Editor

High rate of MRD-responses in young and fit patients with IGHV mutated chronic lymphocytic leukemia treated with front-line fludarabine, cyclophosphamide, and intensified dose of ofatumumab (FCO2)

Francesca R Mauro, Stefano Molica, Stefano Soddu, Fiorella Ilariucci, Marta Coscia, Francesco Zaja, Emanuele Angelucci, Francesca Re, Anna Marina Liberati, Alessandra Tedeschi, Gianluigi Reda, Daniela Pietrasanta, Alessandro Gozzetti, Roberta Battistini, Giovanni Del Poeta, Caterina Musolino, Mauro Nanni, Alfonso Piciocchi, Marco Vignetti, Antonino Neri, Francesco Albano, Antonio Cuneo, Ilaria Del Giudice, Irene Della Starza, Maria Stefania De Propris, Sara Raponi, Anna R Guarini, Robin Foà

Letters to the Editor

Germline biallelic PIK3CG mutations in a multifaceted immunodeficiency with immune dysregulation

Marini Thian, Birgit Hoeger, Anton Kamnev, Fiona Poyer, Sevgi Köstel Bal, Michael Caldera, Raúl Jiménez-Heredia, Jakob Huemer, Winfried F. Pickl, Miriam Groß, Stephan Ehl, Carrie L. Lucas, Jörg Menche, Caroline Hutter, Andishe Attarbaschi, Loïc Dupré, Kaan Boztug

Letters to the Editor

Elevated TWIST1 expression in myelodysplastic syndromes/acute myeloid leukemia reduces efficacy of hypomethylating therapy with decitabine

Hongjiao Li, Yi Wang, Xingchen Pang, Chenglian Xie, H. Joachim Deeg, Hui Wang, Ting Wan, Jinpeng Wu, Feng Guan, Xiang Li

Articles

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress

Michiko Ichii, Kenji Oritani, Jun Toda, Hideaki Saito, Henyun Shi, Hirohiko Shibayama, Daisuke Motooka, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Daisuke Okuzaki, Tadashi Matsuda, Yuzuru Kanakura

Articles

Alternative activation of human macrophages enhances tissue factor expression and production of extracellular vesicles

Philipp J. Hohensinner, Julia Mayer, Julia Kichbacher, Julia Kral-Pointner, Barbara Thaler, Christoph Kaun, Lena Hell, Patrick Haider, Marion Mussbacher, Johannes A. Schmid, Stefan Stojkovic, Svitlana Demyanets, Michael B. Fischer, Kurt Huber, Katharina Wöran, Christian Hengstenberg, Walter S. Speidl, Rudolf Oehler, Ingrid Pabinger, Johann Wojta

Articles

CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs

Jiahuan Chen, Beiying An, Biao Yu, Xiaohuan Peng, Hongming Yuan, Qiangbing Yang, Xue Chen, Tingting Yu, Lingyu Wang, Xinwei Zhang, He Wang, Xiaodong Zou, Daxin Pang, Hongsheng Ouyang, Xiaochun Tang

Articles

Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study

Alexander C. Leeksma, Panagiotis Baliakas, Theodoros Moysiadis, Anna Puiggros, Karla Plevova, Anne-Marie van der Kevie-Kersemaekers, Hidde Posthuma, Ana E. Rodriguez-Vicente, Anh Nhi Tran, Gisela Barbany, Larry Mansouri, Rebeqa Gunnarsson, Helen Parker, Eva van den Berg, Mar Bellido, Zadie Davis, Meaghan Wall, Ilaria Scarpelli, Anders Österborg, Lotta Hansson, Marie Jarosova, Paolo Ghia, Pino Poddighe, Blanca Espinet, Sarka Pospisilova, Constantine Tam, Loïc Ysebaert, Florence Nguyen-Khac, David Oscier, Claudia Haferlach, Jacqueline Schoumans, Marian Stevens-Kroef, Eric Eldering, Kostas Stamatopoulos, Richard Rosenquist, Jonathan C. Strefford, Clemens Mellink, Arnon P. Kater

Articles

Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium.

Timo Rademakers, Marieke Goedhart, Mark Hoogenboezem, Alexander García Ponce, Jos van Rijssel, Maryna Samus, Michael Schnoor, Stefan Butz, Stephan Huveneers, Dietmar Vestweber, Martijn A. Nolte, Carlijn Voermans, Jaap D. van Buul

Articles

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance

Yingchun Wang, Wenchun Chen, Wei Zhang, Melissa M. Lee-Sundlov, Caterina Casari, Michael C. Berndt, Francois Lanza, Wolfgang Bergmeier, Karin M. Hoffmeister, X. Frank Zhang, Renhao Li

Articles

AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes

Minke A.E. Rab, Brigitte A. van Oirschot, Penelope A. Kosinski, Jeffrey Hixon, Kendall Johnson, Victor Chubukov, Lenny Dang, Gerard Pasterkamp, Stephanie van Straaten, Wouter W. van Solinge, Eduard J. van Beers, Charles Kung, Richard van Wijk

Articles

Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel

Sihe Jiang, Olaf Penack, Tobias Terzer, David Schult, Joshua Majer-Lauterbach, Aleksandar Radujkovic, Igor W. Blau, Lars Bullinger, Carsten Müller-Tidow, Peter Dreger, Thomas Luft

Articles

MicroRNA-21 maintains hematopoietic stem cell homeostasis through sustaining the NF-κB signaling pathway in mice

Mengjia Hu, Yukai Lu, Hao Zeng, Zihao Zhang, Shilei Chen, Yan Qi, Yang Xu, Fang Chen, Yong Tang, Mo Chen, Changhong Du, Mingqiang Shen, Fengchao Wang, Yongping Su, Song Wang, Junping Wang

Letters to the Editor

Venetoclax as monotherapy and in combination with hypomethylating agents or low dose cytarabine in relapsed and treatment refractory acute myeloid leukemia: a systematic review and meta-analysis

Jan Philipp Bewersdorf, Smith Giri, Rong Wang, Robert T. Williams, Martin S. Tallman, Amer M. Zeidan, Maximilian Stahl

Letters to the Editor

The role of 18F-FDG-PET in detecting Richter's transformation of chronic lymphocytic leukemia in patients receiving therapy with a B-cell receptor inhibitor

Yucai Wang, Kari G. Rabe, Michael S. Bold, Min Shi, Curtis A. Hanson, Susan M. Schwager, Timothy G. Call, Saad S. Kenderian, Eli Muchtar, Suzanne R. Hayman, Amber B. Koehler, Amie L. Fonder, Asher A. Chanan-Khan, Daniel L. Van Dyke, Susan L. Slager, Neil E. Kay, Wei Ding, Jose F. Leis, Sameer A. Parikh

Letters to the Editor

T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients

Javier Sánchez-Céspedes, José Antonio Marrugal-Lorenzo, Cecilia Martín-Gandul, Nancy Rodríguez-Torres, Enrique Montero-Mateos, Ana Serna-Gallego, Virginia Escamilla-Gómez, Laura Merino, Ildefonso Espigado, Jerónimo Pachón, José Antonio Pérez-Simón, Manuela Aguilar-Guisado

Articles

Low dose Btk inhibitors selectively block platelet activation by CLEC-2

Phillip L.R. Nicolson, Sophie H. Nock, Joshua Hinds, Lourdes Garcia-Quintanilla, Christopher W. Smith, Joana Campos, Alexander Brill, Jeremy A. Pike, Abdullah O. Khan, Natalie S. Poulter, Diedre M. Kavanagh, Stephanie Watson, Callum N. Watson, Hayley Clifford, Aarnoud P. Huissoon, Alice Y. Pollitt, Johannes A. Eble, Guy Pratt, Steve P. Watson, Craig E. Hughes

Articles

Autologous stem cell transplantation for progressive systemic sclerosis: a prospective non-interventional study from the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party

Joerg Henes, Maria Carolina Oliveira, Myriam Labopin, Manuela Badoglio, Hans Ulrich Scherer, Nicoletta Del Papa, Thomas Daikeler, Marc Schmalzing, Roland Schroers, Thierry Martin, Gregory Pugnet, Belinda Simoes, David Michonneau, Erik W.A. Marijt, Bruno Lioure, Jacques Olivier Bay, John A. Snowden, Montserrat Rovira, Anne Huynh, Francesco Onida, Lothar Kanz, Zora Marjanovic, Dominique Farge

Articles

Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria

Robert A. Brodsky, Régis Peffault de Latour, Scott T. Rottinghaus, Alexander Röth, Antonio M. Risitano, Ilene C. Weitz, Peter Hillmen, Jaroslaw P. Maciejewski, Jeff Szer, Jong Wook Lee, Austin G. Kulasekararaj, Lori Volles, Andrew I. Damokosh, Stephan Ortiz, Lori Shafner, Peng Liu, Anita Hill, Hubert Schrezenmeier

Articles

Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis

Valentina Capo, Sara Penna, Ivan Merelli, Matteo Barcella, Serena Scala, Luca Basso-Ricci, Elena Draghici, Eleonora Palagano, Erika Zonari, Giacomo Desantis, Paolo Uva, Roberto Cusano, Lucia Sergi Sergi, Laura Crisafulli, Despina Moshous, Polina Stepensky, Katarzyna Drabko, Zühre Kaya, Ekrem Unal, Alper Gezdirici, Giuseppe Menna, Marta Serafini, Alessandro Aiuti, Silvia Laura Locatelli, Carmelo Carlo-Stella, Ansgar S. Schulz, Francesca Ficara, Cristina Sobacchi, Bernhard Gentner, Anna Villa

Letters to the Editor

High-throughput analysis of the T cell receptor gene repertoire in low-count monoclonal B cell lymphocytosis reveals a distinct profile from chronic lymphocytic leukemia

Andreas Agathangelidis, Chrysi Galigalidou, Lydia Scarfò, Theodoros Moysiadis, Alessandra Rovida, Elisavet Vlachonikola, Electra Sofou, Fotis Psomopoulos, Anna Vardi, Pamela Ranghetti, Alexandra Siorenta, Alex Galanis, Kostas Stamatopoulos, Anastasia Chatzidimitriou, Paolo Ghia

Letters to the Editor

HLA-DRB1*11 is a strong risk factor for acquired thrombotic thrombocytopenic purpura in children

Bérangère S. Joly, Pascale Loiseau, Michael Darmon, Thierry Leblanc, Hervé Chambost, Fanny Fouyssac, Vincent Guigonis, Jérôme Harambat, Alain Stepanian, Paul Coppo, Agnès Veyradier

Articles

Inhibitor incidence in an unselected cohort of previously untreated patients with severe haemophilia B: a PedNet study

Christoph Male, Nadine G. Andersson, Anne Rafowicz, Ri Liesner, Karin Kurnik, Kathelijn Fischer, Helen Platokouki, Elena Santagostino, Hervé Chambost, Beatrice Nolan, Christoph Königs, Gili Kenet, Rolf Ljung, Marijke van den Berg, PedNet study group

Articles

Analysis of retrotransposon subfamily DNA methylation reveals novel early epigenetic changes in chronic lymphocytic leukaemia

Timothy M. Barrow, Nicole Wong Doo, Roger L. Milne, Graham G. Giles, Elaine Willmore, Gordon Strathdee, Hyang-Min Byun

Articles

A role for hepcidin in the anemia caused by Trypanosoma brucei infection

João V. Neves, Ana C. Gomes, David M. Costa, Carolina Barroso, Sophie Vaulont, Anabela Cordeiro da Silva, Joana Tavares, Pedro N.S. Rodrigues

Articles

A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency

Chantal Lagresle-Peyrou, Aurélien Olichon, Hanem Sadek, Philippe Roche, Claudine Tardy, Cindy Da Silva, Alexandrine Garrigue, Alain Fischer, Despina Moshous, Yves Collette, Capucine Picard, Jean Laurent Casanova, Isabelle André, Marina Cavazzana

Articles

Induction of erythroferrone in healthy humans by micro-dose recombinant erythropoietin or high-altitude exposure

Paul Robach, Elena Gammella, Stefania Recalcati, Domenico Girelli, Annalisa Castagna, Matthieu Roustit, Carsten Lundby, Anne-Kristine Lundby, Pierre Bouzat, Samuel Vergès, Guillaume Séchaud, Pierluigi Banco, Mario Uhr, Catherine Cornu, Pierre Sallet, Gaetano Cairo

Articles

HES1 and HES4 have non-redundant roles downstream of Notch during early human T cell development.

Matthias De Decker, Marieke Lavaert, Juliette Roels, Laurentijn Tilleman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Pieter Van Vlierberghe, Tom Taghon

Articles

Targeting CD205 with the antibody drug conjugate MEN1309/OBT076 is an active new therapeutic strategy in lymphoma models

Eugenio Gaudio, Chiara Tarantelli, Filippo Spriano, Francesca Guidetti, Giulio Sartori, Roberta Bordone, Alberto J. Arribas, Luciano Cascione, Mario Bigioni, Giuseppe Merlino, Alessio Fiascarelli, Alessandro Bressan, Afua Adjeiwaa Mensah, Gaetanina Golino, Renzo Lucchini, Elena Bernasconi, Davide Rossi, Emanuele Zucca, Georg Stussi, Anastasios Stathis, Robert S. Boyd, Rachel L. Dusek, Arnima Bisht, Nickolas Attanasio, Christian Rohlff, Andrea Pellacani, Monica Binaschi, Francesco Bertoni

Articles

Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins

Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, Ignacio García-Tuñón, Manuel Sánchez-Martín, Ángel Hernández-Hernández

Articles

Preclinical development of a humanized chimeric antigen receptor against B cell maturation antigen for multiple myeloma

Lorena Perez-Amill, Guillermo Suñe, Asier Antoñana-Vildosola, Maria Castella, Amer Najjar, Jaume Bonet, Narcis Fernández-Fuentes, Susana Inogés, Ascensión López, Clara Bueno, Manel Juan, Alvaro Urbano-Ispizua, Beatriz Martín-Antonio

Articles

Prospective isolation of radiation induced erythroid stress progenitors reveals unique transcriptomic and epigenetic signatures enabling increased erythroid output

Sofie Singbrant, Alexander Mattebo, Mikael Sigvardsson, Tobias Strid, Johan Flygare

Articles

WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia

Juncheng Hu, Tianci Wang, Jin Xu, Sanyun Wu, Liyuan Wang, Hexiu Su, Jue Jiang, Ming Yue, Jingchao Wang, Donghai Wang, Peng Li, Fuling Zhou, Yu Liu, Guoliang Qing, Hudan Liu

Articles

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1

Eugen Tausch, Philipp Beck, Richard F. Schlenk, Billy J. Jebaraj, Anna Dolnik, Deyan Y. Yosifov, Peter Hillmen, Fritz Offner, Ann Janssens, K. Govind Babu, Sebastian Grosicki, Jiri Mayer, Panagiotis Panagiotidis, Astrid McKeown, Ira V. Gupta, Alexandra Skorupa, Celine Pallaud, Lars Bullinger, Daniel Mertens, Hartmut Döhner, Stephan Stilgenbauer

Letters to the Editor

Phlebotomy as an efficient long-term treatment of congenital erythropoietic porphyria

Arienne Mirmiran, Antoine Poli, Cecile Ged, Caroline Schmitt, Thibaud Lefebvre, Hana Manceau, Raêd Daher, Boualem Moulouel, Katell Peoc'h, Sylvie Simonin, Jean-Marc Blouin, Jean-Charles Deybach, Gaël Nicolas, Hervé Puy, Emmanuel Richard, Laurent Gouya

Letters to the Editor

High expression of the stem cell marker GPR56 at diagnosis identifies acute myeloid leukemia patients at higher relapse risk after allogeneic stem cell transplantation in context with the CD34+/CD38- population

Madlen Jentzsch, Marius Bill, Juliane Grimm, Julia Schulz, Luba Schuhmann, Dominic Brauer, Karoline Goldmann, Franziska Wilke, Georg-Nikolaus Franke, Gerhard Behre, Wolfram Pönisch, Vladan Vucinic, Dietger Niederwieser, Uwe Platzbecker, Sebastian Schwind

Articles

Measurable residual disease monitoring provides insufficient lead-time to prevent morphologic relapse in the majority of patients with core-binding factor acute myeloid leukemia

Robert Puckrin, Eshetu G. Atenafu, Jaime O. Claudio, Steven Chan, Vikas Gupta, Dawn Maze, Caroline McNamara, Tracy Murphy, Andre C. Shuh, Karen Yee, Hassan Sibai, Mark D. Minden, Cuihong Wei, Tracy Stockley, Suzanne Kamel-Reid, Aaron D. Schimmer

Articles

Early progression of disease predicts shorter survival in MALT lymphoma patients receiving systemic treatment

Annarita Conconi, Catherine Thieblemont, Luciano Cascione, Valter Torri, Barbara Kiesewetter, Gloria Margiotta Casaluci, Gianluca Gaidano, Markus Raderer, Franco Cavalli, Armando Lopez Guillermo, Peter W. Johnson, Emanuele Zucca

Articles

Prognostic impact of prevalent chronic lymphocytic leukemia stereotyped subsets: analysis within prospective clinical trials of the German CLL Study Group (GCLLSG)

Sonia Jaramillo, Andreas Agathangelidis, Christof Schneider, Jasmin Bahlo, Sandra Robrecht, Eugen Tausch, Johannes Bloehdorn, Manuela Hoechstetter, Kirsten Fischer, Barbara Eichhorst, Valentin Goede, Michael Hallek, Hartmut Döhner, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos, Stephan Stilgenbauer

Articles

Clinical significance of occult central nervous system disease in adult acute lymphoblastic leukemia. A multicenter report from the campus all network

Maria Ilaria Del Principe, Elisa Buzzatti, Alfonso Piciocchi, Fabio Forghieri, Massimiliano Bonifacio, Federica Lessi, Silvia Imbergamo, Enrico Orciuolo, Giovanni Rossi, Nicola Fracchiolla, Silvia Trappolini, Benedetta Neri, Chiara Sarlo, Patrizia Zappasodi, Michelina Dargenio, Mariagiovanna Cefalo, Maria Antonietta Irno-Consalvo, Consuelo Conti, Giovangiacinto Paterno, Gottardo De Angelis, Mariarita Sciumè, Irene Della Starza, Adriano Venditti, Robin Foà, Anna Rita Guarini

Articles

Standardized monitoring of cytomegalovirus-specific immunity can improve risk stratification of recurrent cytomegalovirus reactivation after hematopoietic stem cell transplantation

Eva Wagner-Drouet, Daniel Teschner, Christine Wolschke, Dietlinde Janson, Kerstin Schäfer-Eckart, Johannes Gärtner, Stephan Mielke, Martin Schreder, Guido Kobbe, Mustafa Kondakci, Inken Hilgendorf, Marie von Lilienfeld-Toal, Stefan Klein, Daniela Heidenreich, Sebastian Kreil, Mareike Verbeek, Sandra Graß, Markus Ditschkowski, Tanja Gromke, Martina Koch, Monika Lindemann, Thomas Hünig, Traudel Schmidt, Anne Rascle, Harald Guldan, Sascha Barabas, Ludwig Deml, Ralf Wagner, Daniel Wolff

Articles

Migfilin supports hemostasis and thrombosis through regulating platelet αIIbβ3 outside-in signaling.

Yangfan Zhou, Mengjiao Hu, Xiaoyan Chen, Shuai Wang, Jingke Li, Lina Sa, Li Li, Jiaqi Huang, Hongqiang Cheng, Hu Hu

Articles

Novel aptamer to von Willebrand factor A1 domain (TAGX-0004) shows total inhibition of thrombus formation superior to ARC1779 and comparable to caplacizumab

Kazuya Sakai, Tatsuhiko Someya, Kaori Harada, Hideo Yagi, Taei Matsui, Masanori Matsumoto

Articles

Somatic mutations and T-cell clonality in patients with immunodeficiency

Paula Savola, Timi Martelius, Matti Kankainen, Jani Huuhtanen, Sofie Lundgren, Yrjö Koski, Samuli Eldfors, Tiina Kelkka, Mikko A.I. Keränen, Pekka Ellonen, Panu E. Kovanen, Soili Kytölä, Janna Saarela, Harri Lähdesmäki, Mikko R.J. Seppänen, Satu Mustjoki

Articles

Leukemia cells remodel marrow adipocytes via TRPV4-dependent lipolysis

Shaoxin Yang, Wei Lu, Chong Zhao, Yuanmei Zhai, Yanyu Wei, Jiali Liu, Yehua Yu, Zhiqiang Li, Jun Shi

Articles

Treatment of patients with MYC rearrangement positive large B-cell lymphoma with R-CHOP plus lenalidomide: results of a multicenter HOVON phase II trial

Martine E.D. Chamuleau, Coreline N. Burggraaff, Marcel Nijland, Katerina Bakunina, Rogier Mous, Pieternella J. Lugtenburg, Daan Dierickx, Gustaaf W. van Imhoff, Joost S.P. Vermaat, Erik A.F. Marijt, Otto Visser, Caroline Mandigers, Yavuz M. Bilgin, Aart Beeker, Mark F. Durian, Bas van Rees, Lara H. Bohmer, Lidwine W. Tick, Rinske S. Boersma, Tjeerd J.F. Snijders, Harry C. Schouten, Harry R. Koene, Eva de Jongh, Nathalie Hijmering, Arjan Diepstra, Anke van den Berg, Anne I.J. Arens, Julia Huijbregts, Otto Hoekstra, Josee M. Zijlstra, Daphne de Jong, Marie José Kersten

Articles

Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet life span

Irene Marini, Jan Zlamal, Christoph Faul, Ursula Holzer, Stefanie Hammer, Lisann Pelzl, Wolfgang Bethge, Karina Althaus, Tamam Bakchoul

Articles

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

Ilaria M.C. Orlando, Véronique N. Lafleur, Federica Storti, Patrick Spielmann, Lisa Crowther, Sara Santambrogio, Johannes Schödel, David Hoogewijs, David R. Mole, Roland H. Wenger

Articles

Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity

Vinothkumar Rajan, Nicole Melong, Wing Hing Wong, Benjamin King, R. Spencer Tong, Nithin Mahajan, Daniel Gaston, Troy Lund, David Rittenberg, Graham Dellaire, Clinton J.V. Campbell, Todd Druley, Jason N. Berman

Letters to the Editor

Long-term outcomes after splenectomy in children with immune thrombocytopenia: an update on the registry data from the Intercontinental Cooperative ITP Study Group

Maria L. Avila, Nour Amiri, Eleanor Pullenayegum, Victor Blanchette, Paul Imbach, Thomas Kühne, Intercontinental Cooperative ITP Study Group

Letters to the Editor

The novel L-nucleoside analogue, 5-Fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia

Aniket Bankar, Thirushi Piyumika Siriwardena, Biljana Rizoska, Christina Rydergård, Helen Kylefjord, Vilma Rraklli, Anders Eneroth, Pedro Pinho, Stefan Norin, Johan Bylund, Sara Moses, Richard Bethell, Simon Kavanagh, Neil Maclean, Marcela Gronda, Xiaoming Wang, Rose Hurren, Mark D. Minden, Paul Targett-Adams, Aaron D. Schimmer, Mark Albertella

Articles

Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation

Gael B. Morrow, Claire S. Whyte, Nicola J. Mutch

Articles

Targeting CD47/TNFAIP8 by miR-155 overcomes drug resistance and inhibits tumor growth through induction of phagocytosis and apoptosis in multiple myeloma

Nasrin Rastgoo, Jian Wu, Mariah Liu, Maryam Pourabdollah, Eshetu G. Atenafu, Donna Reece, Weimin Chen, Hong Chang

Articles

Tandem autologous hematopoietic stem cell transplantation for treatment of adult T-cell lymphoblastic lymphoma: a multiple center prospective study in China

Yao Liu, Jun Rao, Jiali Li, Qin Wen, Sanbin Wang, Shifeng Lou, Tonghua Yang, Bin Li, Lei Gao, Cheng Zhang, Peiyan Kong, Li Gao, Maihong Wang, Lidan Zhu, Xixi Xiang, Sha Zhou, Xue Liu, Xiangui Peng, Jiangfan Zhong, Xi Zhang

Articles

Myeloproliferative and lymphoproliferative malignancies occurring in the same patient: a nationwide discovery cohort

Johanne M. Holst, Trine L. Plesner, Martin B. Pedersen, Henrik Frederiksen, Michael B. Møller, Michael R. Clausen, Marcus C. Hansen, Stephen Jacques Hamilton-Dutoit, Peter Nørgaard, Preben Johansen, Tobias Ramm Eberlein, Bo K. Mortensen, Gustav Mathiasen, Andreas Øvlisen, Rui Wang, Chao Wang, Weiwei Zhang, Hans Beier Ommen, Jesper Stentoft, Maja Ludvigsen, Wayne Tam, Wing C. Chan, Giorgio Inghirami, Francesco d'Amore

Articles

Predictors of recovery following allogeneic CD34+-selected cell infusion without conditioning to correct poor graft function

Maria M Cuadrado, Richard M Szydlo, Mike Watts, Nishil Patel, Hanna Renshaw, Jude Dorman, Mark Lowdell, Stuart Ings, Chloe Anthias, Alejandro Madrigal, Stephen Mackinnon, Panagiotis Kottaridis, Ben Carpenter, Rachael Hough, Emma Morris, Kirsty Thomson, Karl S Peggs, Ronjon Chakraverty

Articles

Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

Nuno A.G. Graça, Bogac Ercig, Leydi Carolina Velásquez Pereira, Kadri Kangro, Paul Kaijen, Gerry A.F. Nicolaes, Agnès Veyradier, Paul Coppo, Karen Vanhoorelbeke, Andres Männik, Jan Voorberg

Articles

Dominant negative Gfi1b mutations cause moderate thrombocytopenia and an impaired stress thrombopoiesis associated with mild erythropoietic abnormalities in mice

Hugues Beauchemin, Peiman Shooshtharizadeh, Jordan Pinder, Graham Dellaire, Tarik Möröy

Articles

ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies

Oronza A. Botrugno, Silvia Bianchessi, Desirée Zambroni, Michela Frenquelli, Daniela Belloni, Lucia Bongiovanni, Stefania Girlanda, Simona Di Terlizzi, Marina Ferrarini, Elisabetta Ferrero, Maurilio Ponzoni, Magda Marcatti, Giovanni Tonon

Articles

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner

Nicolas Receveur, Dmitry Nechipurenko, Yannick Knapp, Aleksandra Yakusheva, Eric Maurer, Cécile V. Denis, François Lanza, Mikhail Panteleev, Christian Gachet, Pierre H. Mangin

Articles

Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight

Tiffany C. Timmer, Rosa de Groot, Judith J.M. Rijnhart, Jeroen Lakerveld, Johannes Brug, Corine W.M. Perenboom, A. Mireille Baart, Femmeke J. Prinsze, Saurabh Zalpuri, C. Ellen van der Schoot, Wim L.A.M. de Kort, Katja van den Hurk

Articles

The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs

Debora Soncini, Stefania Orecchioni, Samantha Ruberti, Paola Minetto, Claudia Martinuzzi, Luca Agnelli, Katia Todoerti, Antonia Cagnetta, Maurizio Miglino, Marino Clavio, Paola Contini, Riccardo Varaldo, Micaela Bergamaschi, Fabio Guolo, Mario Passalacqua, Alessio Nencioni, Fiammetta Monacelli, Marco Gobbi, Antonino Neri, Giovanni Abbadessa, Sudharshan Eathiraj, Brian Schwartz, Francesco Bertolini, Roberto M. Lemoli, Michele Cea

Articles

Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease

Jing Li, Si-yeon Jeong, Bei Xiong, Alan Tseng, Andrew B. Mahon, Steven Isaacman, Victor R. Gordeuk, Jaehyung Cho

Articles

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

Susanna H. M. Sluka, Simon F. Stämpfli, Alexander Akhmedov, Tanja Klein-Rodewald, Adrián Sanz-Moreno, Marion Horsch, Paula Grest, Andrea S. Rothmeier, Birgit Rathkolb, Anja Schrewe, Johannes Beckers, Frauke Neff, Eckhard Wolf, Giovanni G. Camici, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Thomas F. Lüscher, Wolfram Ruf, Felix C. Tanner

Letters to the Editor

Mixed myeloid chimerism and relapse of myelofibrosis after allogeneic stem cell transplantation

Samer A. Srour, Amanda Olson, Stefan O. Ciurea, Parth Desai, Qaiser Bashir, Betul Oran, Prithviraj Bose, Rohtesh Mehta, Keyur P. Patel, Naveen Pemmaraju, Naval Daver, Srdan Verstovsek, Richard E. Champlin, Uday R. Popat

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

Letters to the Editor

Chunyan Gu, Haibo Cheng, Hongbao Yang, Yong Bian, Yaohui Wang, Yifen Zhang, Michael Pisano, Gang Hu, Ye Yang

Letters to the Editor

MK2 is a therapeutic target for high-risk multiple myeloma

Chunyan Gu, Haibo Cheng, Hongbao Yang, Yong Bian, Yaohui Wang, Yifen Zhang, Michael Pisano, Gang Hu, Ye Yang