Early view

Jul 29, 2021

Editorials
Article

Humoral serologic response to the BNT162b2 vaccine is abrogated in lymphoma patients within the first 12 months following treatment with anti-CD2O antibodies (155 Online Views)

Ronit Gurion, Uri Rozovski, Gilad Itchaki, Anat Gafter-Gvili, Chiya Leibovitch, Pia Raanani, Haim Ben-Zvi, Moran Szwarcwort, Mor Taylor-Abigadol, Eldad J. Dann, Nurit Horesh, Tsofia Inbar, Inna Tzoran, Noa Lavi, Riva Fineman, Shimrit Ringelstein-Harlev, Netanel A. Horowitz

https://doi.org/10.3324/haematol.2021.279216
Article

Safety and efficacy of BNT162b mRNA Covid19 Vaccine in patients with chronic lymphocytic leukemia (549 Online Views)

Ohad Benjamini, Lior Rokach, Gilad Itchaki, Andrei Braester, Lev Shvidel, Neta Goldschmidt, Shirley Shapira, Najib Dally, Abraham Avigdor, Galia Rahav, Yaniv Lustig, Shirley Shapiro Ben David, Riva Fineman, Alona Paz, Osnat Bairey, Aaron Polliack, Ilana Levy, Tamar Tadmor

https://doi.org/10.3324/haematol.2021.279196

Review Articles

Articles

UBA6 and NDFIP1 regulate the degradation of ferroportin (111 Online Views)

Lisa Traeger, Steffen B. Wiegand, Andrew J. Sauer, Benjamin H.P. Corman, Kathryn M. Peneyra, Florian Wunderer, Anna Fischbach, Aranya Bagchi, Rajeev Malhotra, Warren M. Zapol, Donald B. Bloch

https://doi.org/10.3324/haematol.2021.278530

Phase I/II clinical trial of temsirolimus and lenalidomide in patients with relapsed and refractory lymphomas (176 Online Views)

Ajay Major, Justin Kline, Theodore G. Karrison, Paul A. S. Fishkin, Amy S. Kimball, Adam M. Petrich, Sreenivasa Nattam, Krishna Rao, Bethany G. Sleckman, Kenneth Cohen, Koen van Besien, Aaron P. Rapoport, Sonali M. Smith

https://doi.org/10.3324/haematol.2021.278853

Letters to the Editor

Dual pyroptotic biomarkers predict erythroid response in lower risk non-del(5q) myelodysplastic syndromes treated with lenalidomide and recombinant erythropoietin (83 Online Views)

Chen Wang, Kathy L McGraw, Amy F McLemore, Rami Komrokji, Ashley A Basiorka, Najla Al Ali, Jeffrey E. Lancet, Eric Padron, Olivier Kosmider, Michaela Fontenay, Pierre Fenaux, Alan F List, David A. Sallman

https://doi.org/10.3324/haematol.2021.278855

Allogeneic hematopoietic stem cell transplantation from nonsibling 10/10 HLA-matched related donors: a single-center experience (71 Online Views)

Yaoyao Shen, Jiaqian Qi, Jia Chen, Yang Xu, Feng Chen, Xiao Ma, Miao Miao, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Depei Wu, Ying Wang

https://doi.org/10.3324/haematol.2021.278933

Case Reports

Dominance of an UBA1 mutant clone over a CALR mutant clone: from essential thrombocytemia to VEXAS. (112 Online Views)

Mehdi Hage-Sleiman, Sophie Lalevée, Hélène Guermouche, Fabrizia Favale, Michael Chaquin, Maxime Battistella, Jean-David Bouaziz, Martine Bagot, François Delhommeau, Florence Cordoliani, Pierre Hirsch

https://doi.org/10.3324/haematol.2021.279418

Jul 22, 2021

Articles

Dose-Adjusted Epoch and Rituximab for the treatment of double expressor and double hit diffuse large B-cell lymphoma: impact of TP53 mutations on clinical outcome (247 Online Views)

Anna Dodero, Anna Guidetti, Fabrizio Marino, Alessandra Tucci, Francesco Barretta, Alessandro Re, Monica Balzarotti, Cristiana Carniti, Chiara Monfrini, Annalisa Chiappella, Antonello Cabras, Fabio Facchetti, Martina Pennisi, Daoud Rahal, Valentina Monti, Liliana Devizzi, Rosalba Miceli, Federica Cocito, Lucia Farina, Francesca Ricci, Giuseppe Rossi, Carmelo Carlo-Stella, Paolo Corradini

https://doi.org/10.3324/haematol.2021.278638

Prephase rituximab/prednisone therapy and aging-related, pro-inflammatory cytokine milieu in older, vulnerable patients with newly diagnosed diffuse large B-cell lymphoma (247 Online Views)

Richard J. Lin, Colette N. Owens, Esther Drill, Augustine Iannotta, Mayan Oliveros, Dylan L. Schick, Ariela Noy, John F. Gerecitano, Pamela R. Drullinsky, Philip C. Caron, Anita Kumar, Matthew J. Matasar, Craig Moskowitz, Beatriz Korc-Grodzicki, Andrew D. Zelenetz, Gilles A. Salles, Paul A. Hamlin

https://doi.org/10.3324/haematol.2021.278719

Complement dysregulation is associated with severe COVID-19 illness (473 Online Views)

Jia Yu, Gloria F. Gerber, Hang Chen, Xuan Yuan, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky

https://doi.org/10.3324/haematol.2021.279155

Jul 15, 2021

Review Articles

2021 European Myeloma Network review and consensus statement on smoldering multiple myeloma: how to distinguish (and manage) Dr. Jekyll and Mr. Hyde (531 Online Views)

Pellegrino Musto, Monika Engelhardt, Jo Caers, Niccolo’ Bolli, Martin Kaiser, Niels van de Donk, Evangelos Terpos, Annemiek Broijl, Carlos Fernández de Larrea, Francesca Gay, Hartmut Goldschmidt, Roman Hajek, Annette Juul Vangsted, Elena Zamagni, Sonja Zweegman, Michele Cavo, Meletios Dimopoulos, Hermann Einsele, Heinz Ludwig, Giovanni Barosi, Mario Boccadoro, Maria-Victoria Mateos, Pieter Sonneveld, Jesus San Miguel

https://doi.org/10.3324/haematol.2021.278519

Articles

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia (164 Online Views)

Dimitrios Papaioannou, Hatice G. Ozer, Deedra Nicolet, Amog P. Urs, Tobias Herold, Krzysztof Mrózek, Aarif M.N. Batcha, Klaus H. Metzeler, Ayse S. Yilmaz, Stefano Volinia, Marius Bill, Jessica Kohlschmidt, Maciej Pietrzak, Christopher J. Walker, Andrew J. Carroll, Jan Braess, Bayard L. Powell, Ann-Kathrin Eisfeld, Geoffrey L. Uy, Eunice S. Wang, Jonathan E. Kolitz, Richard M. Stone, Wolfgang Hiddemann, John C. Byrd, Clara D. Bloomfield, Ramiro Garzon

https://doi.org/10.3324/haematol.2021.266643

Letters to the Editor

Case Reports

Massive cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (229 Online Views)

Sara Bonato, Andrea Artoni, Anna Lecchi, Ghil Schwarz, Silvia La Marca, Lidia Padovan, Marigrazia Clerici, Chiara Guadino, Giacomo Pietro Comi, Armando Tripodi, Flora Peyvandi

https://doi.org/10.3324/haematol.2021.279246

Intracerebral hemorrhage associated with vaccine-induced thrombotic thrombocytopenia following ChAdOx1 nCOVID-19 vaccine in a pregnant woman (686 Online Views)

Daniela P. Mendes-de-Almeida, Remy Martins-Gonçalves, Renata Morato-Santos, Gustavo Adolpho C. de Carvalho, Silas A. Martins, Lohanna Palhinha, Vanessa Sandim, Elyzabeth Avvad-Portari, Fernando A. Bozza, Robson Q. Monteiro, Patrícia T. Bozza, Pedro Kurtz

https://doi.org/10.3324/haematol.2021.279407

Jul 8, 2021

Articles

Toxicity and efficacy of chimeric antigen receptor T-cell in patients with diffuse large B cell lymphoma above the age of 70 years compare to younger patients – a matched control multi-center cohort study (541 Online Views)

Ron Ram, Sigal Grisariu, Liat Shargian-Alon, Odelia Amit, Yaeli Bar-On, Polina Stepensky, Moshe Yeshurun, Batia Avni, David Hagin, Chava Perry, Ronit Gurion, Nadav Sarid, Yair Herishanu, Ronit Gold, Chen Glait-Santar, Sigi Kay, Irit Avivi

https://doi.org/10.3324/haematol.2021.278288

Germline GATA2 variant disrupting endothelial eNOS cell function and angiogenesis can be restored by c-Jun/AP-1 upregulation (218 Online Views)

Giulio Purgatorio, Elisa Piselli, Giuseppe Guglielmini, Emanuela Falcinelli, Loredana Bury, Valeria Di Battista, Fabrizia Pellanera, Francesca Milano, Caterina Matteucci, Cristina Mecucci, Paolo Gresele

https://doi.org/10.3324/haematol.2021.278450

Letters to the Editor

Single-cell profiling reveals the dynamics of cytomegalovirusspecific T-cells in haploidentical hematopoietic stem cell transplantation (200 Online Views)

Jasper J. P. van Beek, Simone Puccio, Alessandra Roberto, Federica De Paoli, Giulia Graziano, Elisa Salviato, Giorgia Alvisi, Veronica Zanon, Alice Scarpa, Elisa Zaghi, Michela Calvi, Clara Di Vito, Rossana Mineri, Barbara Sarina, Chiara De Philippis, Armando Santoro, Jacopo Mariotti, Stefania Bramanti, Francesco Ferrari, Luca Castagna, Domenico Mavilio, Enrico Lugli

https://doi.org/10.3324/haematol.2020.276352

Acalabrutinib for treatment of diffuse large B-cell lymphoma: results from a phase 1b study (340 Online Views)

Paolo Strati, Sven de Vos, Jia Ruan, Kami J. Maddocks, Christopher R. Flowers, Simon Rule, Priti Patel, Yan Xu, Helen Wei, Melanie M. Frigault, Roser Calvo, Martin J.S. Dyer

https://doi.org/10.3324/haematol.2021.278654

Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia (146 Online Views)

Jessica Leonard, Joelle SJ Wolf, Michelle Degnin, Christopher A. Eide, Dorian LaTocha, Kyle Lenz, Beth Wilmot, Charles G. Mullighan, Mignon Loh, Stephen P Hunger, Brian J Druker, Marc M Loriaux, Jeffrey W Tyner, Bill H Chang

https://doi.org/10.3324/haematol.2021.278692

The RUNX1 Database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy (509 Online Views)

Claire C. Homan, Sarah L. King-Smith, David M. Lawrence, Peer Arts, Jinghua Feng, James Andrews, Mark Armstrong, Thuong Ha, Julia Dobbins, Michael W. Drazer, Kai Yu, Csaba Bödör, Alan Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Jude Fitzgibbon, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V. Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Rienhoff, Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Velloso, Benedict Yan, Paul Liu, Lucy A. Godley, Andreas W. Schreiber, Christopher N. Hahn, Hamish S. Scott, Anna L. Brown

https://doi.org/10.3324/haematol.2021.278762

Sex-dependent membranopathy in stored human red blood cells (155 Online Views)

Ewa Szczesny-Malysiak, Tasnim Mohaissen, Katarzyna Bulat, Magdalena Kaczmarska, Aleksandra Wajda, Katarzyna M. Marzec

https://doi.org/10.3324/haematol.2021.278895

Case Reports

Successful pregnancies after transplantation of ovarian tissue retrieved and cryopreserved at time of childhood acute lymphoblastic leukemia – A case report (280 Online Views)

Kenny A. Rodriguez-Wallberg, Milan Milenkovic, Kiriaki Papaikonomou, Victoria Keros, Britt Gustafsson, Fotios Sergouniotis, Ida Wikander, Ronak Perot, Birgit Borgström, Per Ljungman, Gisela Barbany

https://doi.org/10.3324/haematol.2021.278828

Jul 1, 2021

Editorials
Article

Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy (246 Online Views)

Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling

https://doi.org/10.3324/haematol.2021.278411

Review Articles

Articles

Long-term outcomes from the Phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma (924 Online Views)

Johannes Duell, Kami J Maddocks, Eva González-Barca, Wojciech Jurczak, Anna Marina Liberati, Sven de Vos, Zsolt Nagy, Aleš Obr, Gianluca Gaidano, Pau Abrisqueta, Nagesh Kalakonda, Marc André, Martin Dreyling, Tobias Menne, Olivier Tournilhac, Marinela Augustin, Andreas Rosenwald, Maren Dirnberger-Hertweck, Johannes Weirather, Sumeet Ambarkhane, Gilles Salles

https://doi.org/10.3324/haematol.2020.275958

A homozygous duplication of the FGG exon 8-intron 8 junction causes congenital afibrinogenemia. Lessons learned from the study of a large consanguineous Turkish family (169 Online Views)

Michel Guipponi, Frédéric Masclaux, Frédérique Sloan-Béna, Corinne Di Sanza, Namik Özbek, Flora Peyvandi, Marzia Menegatti, Alessandro Casini, Baris Malbora, Marguerite Neerman-Arbez

https://doi.org/10.3324/haematol.2021.278945

Letters to the Editor

IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kδ inhibitor idelalisib (373 Online Views)

Veronika Sandova, Gabriela Mladonicka Pavlasova, Vaclav Seda, Katerina Amruz Cerna, Sonali Sharma, Veronika Palusova, Yvona Brychtova, Sarka Pospisilova, Stacey M. Fernandes, Anna Panovska, Michael Doubek, Matthew S. Davids, Jennifer R. Brown, Jiri Mayer, Marek Mraz

https://doi.org/10.3324/haematol.2021.278644

Therapeutic potential of ruxolitinib and ponatinib in patients with EPOR-rearranged Philadelphia chromosome-like acute lymphoblastic leukemia (236 Online Views)

Lisa M Niswander, Joseph P Loftus, Élodie Lainey, Aurélie Caye-Eude, Morgane Pondrom, David A Hottman, Ilaria Iacobucci, Charles G Mullighan, Nitin Jain, Marina Konopleva, Hélène Cavé, André Baruchel, Pierre S Rohrlich, Sarah K Tasian

https://doi.org/10.3324/haematol.2021.278697

A novel classification of hematologic conditions in patients with Fanconi anemia (234 Online Views)

Yvonne Lisa Behrens, Gudrun Göhring, Randa Bawadi, Sümeyye Cöktü, Christina Reimer, Beatrice Hoffmann, Birte Sänger, Simon Käfer, Felicitas Thol, Miriam Erlacher, Charlotte M. Niemeyer, Irith Baumann, Reinhard Kalb, Detlev Schindler, Christian Peter Kratz

https://doi.org/10.3324/haematol.2021.279332

Jun 24, 2021

Articles

Improved outcome of patients with graft-versus-host disease after allogeneic hematopoietic cell transplantation for hematologic malignancies over time: an EBMT mega-file study (328 Online Views)

Hildegard T. Greinix, Dirk-Jan Eikema, Linda Koster, Olaf Penack, Ibrahim Yakoub-Agha, Silvia Montoto, Christian Chabannon, Jan Styczynski, Arnon Nagler, Marie Robin, Stephen Robinson, Yves Chalandon, Malgorzata Mikulska, Stefan Schönland, Zinaida Peric, Annalisa Ruggeri, Francesco Lanza, Liesbeth C. de Wreede, Mohamad Mohty, Grzegorz W. Basak, Nicolaus Kröger

https://doi.org/10.3324/haematol.2020.265769

Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B cell lymphoma (400 Online Views)

Sara Napoli, Luciano Cascione, Andrea Rinaldi, Filippo Spriano, Francesca Guidetti, Fangwen Zhang, Maria Teresa Cacciapuoti, Afua Adjeiwaa Mensah, Giulio Sartori, Nicolas Munz, Mattia Forcato, Silvio Bicciato, Annalisa Chiappella, Paola Ghione, Olivier Elemento, Leandro Cerchietti, Giorgio Inghirami, Francesco Bertoni

https://doi.org/10.3324/haematol.2020.267096

Older patients (aged ≥60 years) with previously untreated advanced-stage classical Hodgkin lymphoma: a detailed analysis from the phase III ECHELON-1 study (481 Online Views)

Andrew M. Evens, Joseph M. Connors, Anas Younes, Stephen M. Ansell, Won Seog Kim, John Radford, Tatyana Feldman, Joseph Tuscano, Kerry J. Savage, Yasuhiro Oki, Andrew Grigg, Christopher Pocock, Monika Dlugosz-Danecka, Keenan Fenton, Andres Forero-Torres, Rachael Liu, Hina Jolin, Ashish Gautam, Andrea Gallamini

https://doi.org/10.3324/haematol.2021.278438

Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas (398 Online Views)

Jing Gao, Michelle Y. Wang, Yuan Ren, Tint Lwin, Tao Li, Joy C Yan, Eduardo M. Sotomayor, Derek R Duckett, Bijal D. Shah, Kenneth H. Shain, Xiaohong Zhao, Jianguo Tao

https://doi.org/10.3324/haematol.2021.278743

Natural history of Waldenström macroglobulinemia following acquired resistance to ibrutinib monotherapy (325 Online Views)

Joshua N. Gustine, Shayna Sarosiek, Catherine A. Flynn, Kirsten Meid, Carly Leventoff, Timothy White, Maria Luisa Guerrera, Lian Xu, Amanda Kofides, Nicholas Tsakmaklis, Manit Munshi, Maria Demos, Christopher J. Patterson, Xia Liu, Guang Yang, Zachary R. Hunter, Andrew R. Branagan, Steven P. Treon, Jorge J. Castillo

https://doi.org/10.3324/haematol.2021.279112

Case Reports

Jun 17, 2021

Editorials
Article

Fusion gene detection by RNA sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements (341 Online Views)

Paul Kerbs, Sebastian Vosberg, Stefan Krebs, Alexander Graf, Helmut Blum, Anja Swoboda, Aarif M. N. Batcha, Ulrich Mansmann, Dirk Metzler, Caroline A. Heckman, Tobias Herold, Philipp A. Greif

https://doi.org/10.3324/haematol.2021.278436

Editorials
Article

Efficacy and safety assessment of prolonged maintenance with subcutaneous rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: results of the Phase III MabCute study (339 Online Views)

Simon Rule, Wolney Gois Barreto, Javier Briones, Angelo M. Carella, Olivier Casasnovas, Chris Pocock, Clemens-Martin Wendtner, Francesco Zaja, Susan Robson, Lachlan MacGregor, Roger R. Tschopp, Sonja Nick, Martin Dreyling

https://doi.org/10.3324/haematol.2020.274803

Editorials
Article

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells (192 Online Views)

Orsola di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, John S. Welch

https://doi.org/10.3324/haematol.2021.278603

Articles

The GPIbα intracellular tail – role in transducing VWF- and collagen/GPVI-mediated signaling (259 Online Views)

Adela Constantinescu-Bercu, Yuxiao A. Wang, Kevin J. Woollard, Pierre Mangin, Karen Vanhoorelbeke, James T.B. Crawley, Isabelle I. Salles-Crawley

https://doi.org/10.3324/haematol.2020.278242

Jun 10, 2021

Articles

Inhibitors of A Disintegrin and Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect (327 Online Views)

Roberta Pece, Sara Tavella, Delfina Costa, Serena Varesano, Caterina Camodeca, Doretta Cuffaro, Elisa Nuti, Armando Rossello, Massimo Alfano, Cristina D’Arrigo, Denise Galante, Jean-Louis Ravetti, Marco Gobbi, Francesca Tosetti, Alessandro Poggi, Maria Raffaella Zocchi

https://doi.org/10.3324/haematol.2021.278469

Letters to the Editor

A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies (188 Online Views)

David H. Vandorpe, Boris E. Shmukler, Yann Ilboudo, Swati Bhasin, Beena Thomas, Alicia Rivera, Jay G. Wohlgemuth, Jeffrey S. Dlott, L. Michael Snyder, Colin Sieff, Manoj Bhasin, Guillaume Lettre, Carlo Brugnara, Seth L. Alper

https://doi.org/10.3324/haematol.2021.278770

Jun 3, 2021

Articles

The complex karyotype landscape in chronic lymphocytic leukemia allows to refine the risk of Richter syndrome transformation (383 Online Views)

Andrea Visentin, Laura Bonaldi, Gian Matteo Rigolin, Francesca Romana Mauro, Annalisa Martines, Federica Frezzato, Stefano Pravato, Leila Romano Gargarella, Maria Antonella Bardi, Maurizio Cavallari, Eleonora Volta, Francesco Cavazzini, Mauro Nanni, Monica Facco, Francesco Piazza, Anna Guarini, Robin Foà, Gianpietro Semenzato, Antonio Cuneo, Livio Trentin

https://doi.org/10.3324/haematol.2021.278304

IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load (276 Online Views)

Dianna Hussmann, Anna Starnawska, Louise Kristensen, Iben Daugaard, Astrid Thomsen, Tina E. Kjeldsen, Christine Søholm Hansen, Jonas Bybjerg-Grauholm, Karina Dalsgaard Johansen, Maja Ludvigsen, Thomas Kristensen, Thomas Stauffer Larsen, Michael Boe Møller, Charlotte Guldborg Nyvold, Lise Lotte Hansen, Tomasz K. Wojdacz

https://doi.org/10.3324/haematol.2021.278477

Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome (465 Online Views)

Ayala Tovy, Carina Rosas, Amos S. Gaikwad, Geraldo Medrano, Linda Zhang, Jaime M. Reyes, Yung-Hsin Huang, Tastuhiko Arakawa, Kristen Kurtz, Shannon E. Conneely, Anna G. Guzman, Rogelio Aguilar, Anne Gao, Chun-Wei Chen, Jean J. Kim, Melissa T. Carter, Amaia Lasa-Aranzasti, Irene Valenzuela, Lionel Van Maldergem, Lorenzo Brunetti, M. John Hicks, Andrea N. Marcogliese, Margaret A. Goodell, Rachel E. Rau

https://doi.org/10.3324/haematol.2021.278990

Letters to the Editor

Chromosome 1q21 abnormalities refine outcome prediction in patients with multiple myeloma – a meta-analysis of 2,596 trial patients (537 Online Views)

Niels Weinhold, Hans J. Salwender, David A. Cairns, Marc S. Raab, George Waldron, Igor W. Blau, Uta Bertsch, Thomas Hielscher, Gareth J. Morgan, Anna Jauch, Faith E. Davies, Mathias Hänel, Gordon Cook, Christoph Scheid, Richard Houlston, Hartmut Goldschmidt, Graham Jackson, Martin F. Kaiser

https://doi.org/10.3324/haematol.2021.278888

May 27, 2021

Editorials
Article

Increments in DNA-thioguanine level during thiopurine enhanced maintenance therapy of acute lymphoblastic leukemia (309 Online Views)

Rikke Hebo Larsen, Cecilie Utke Rank, Kathrine Grell, Lisbeth Nørgaard Møller, Ulrik Malthe Overgaard, Peter Kampmann, Jacob Nersting, Matilda Degn, Stine Nygaard Nielsen, Helle Holst, Birgitte Klug Albertsen, Peder Skov Wehner, Michael Thude Callesen, Jukka Kanerva, Thomas Leth Frandsen, Bodil Als-Nielsen, Lisa Lyngsie Hjalgrim, Kjeld Schmiegelow

https://doi.org/10.3324/haematol.2020.278166

Editorials
Article

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study (399 Online Views)

Sabine Kayser, Richard F. Schlenk, Delphine Lebon, Martin Carre, Katharina S. Götze, Friedrich Stölzel, Ana Berceanu, Kerstin Schäfer-Eckart, Pierre Peterlin, Yosr Hicheri, Ramy Rahme, Emmanuel Raffoux, Fatiha Chermat, Stefan W. Krause, Walter E. Aulitzky, Sophie Rigaudeau, Richard Noppeney, Celine Berthon, Martin Görner, Edgar Jost, Philippe Carassou, Ulrich Keller, Corentin Orvain, Thorsten Braun, Colombe Saillard, Ali Arar, Volker Kunzmann, Mathieu Wemeau, Maike de Wit, Dirk Niemann, Caroline Bonmati, Carsten Schwänen, Julie Abraham, Ahmad Aljijakli, Stephanie Haiat, Alwin Krämer, Albrecht Reichle, Martina Gnadler, Christophe Willekens, Karsten Spiekermann, Wolfgang Hiddemann, Carsten Müller-Tidow, Christian Thiede, Christoph Röllig, Hubert Serve, Martin Bornhäuser, Claudia D. Baldus, Eva Lengfelder, Pierre Fenaux, Uwe Platzbecker, Lionel Adès

https://doi.org/10.3324/haematol.2021.278722

Editorials
Article

A Pin1/PML/P53 axis activated by retinoic acid in NPM-1c-acute myeloid leukemia (280 Online Views)

Rita Hleihel, Hiba El Hajj, Hsin-Chieh Wu, Caroline Berthier, Hong-Hu Zhu, Radwan Massoud, Zaher Chakhachiro, Marwan El Sabban; Hugues de The; Ali Bazarbachi

https://doi.org/10.3324/haematol.2020.274878

Editorials
Letter to the Editor

Cluster of differentiation 33 single nucleotide polymorphism rs12459419 is a predictive factor in patients with nucleophosmin1 mutated acute myeloid leukemia receiving gemtuzumab ozogamicin (300 Online Views)

Katrin Teich, Julia Krzykalla, Silke Kapp-Schwoerer, Verena I. Gaidzik, Richard F. Schlenk, Peter Paschka, Daniela Weber, Walter Fiedler, Michael W.M. Kühn, Thomas Schroeder, Karin Mayer, Michael Lübbert, Dhanya Ramachandran, Axel Benner, Arnold Ganser, Hartmut Döhner, Michael Heuser, Konstanze Döhner, Felicitas Thol

https://doi.org/10.3324/haematol.2021.278894

Review Articles

Letters to the Editor

Inclusion of a shRNA targeting BCL11A into a β-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin (417 Online Views)

Silvia Pires Lourenco, Danuta Jarocha; Valentina Ghiaccio, Amaliris Guerra, Osheiza Abdulmalik, Ping La, Alexandra Zezulin, Kim Smith-Whitley, Janet L. Kwiatkowski, Virginia Guzikowski, Yukio Nakamura, Tobias Raabe, Laura Breda, Stefano Rivella

https://doi.org/10.3324/haematol.2020.276634

May 20, 2021

Letters to the Editor

Myeloma NK cells are exhausted and have impaired regulation of activation. (427 Online Views)

Criselle D’Souza, Simon P. Keam, Han Xian Aw Yeang, Michael Neeson, Kelden Richardson, Andy K. Hsu, Rachael Canfield, Natalie Bezman, Michael Robbins, Hang Quach, David S. Ritchie, Simon J. Harrison, Joseph A. Trapani, H. Miles Prince, Paul A. Beavis, Phillip K. Darcy, Paul J. Neeson

https://doi.org/10.3324/haematol.2020.277525

May 13, 2021

Editorials
Article

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality (415 Online Views)

Aaron Issaian, Ariel Hay, Monika Dzieciatkowska, Domenico Roberti, Silverio Perrotta, Zsuzsanna Darula, Jasmina Redzic, Micheal P. Busch, Grier P. Page, Stephen C. Rogers, Allan Doctor, Kirk C. Hansen, Elan Z. Eisenmesser, James C. Zimring, Angelo D’Alessandro

https://doi.org/10.3324/haematol.2020.278252

Letters to the Editor

Targeting BRD4 in acute myeloid leukemia with partial tandem duplication of the MLL gene (340 Online Views)

Marius Bill, Chinmayee Goda, Felice Pepe, Hatice Gulcin Ozer, Betina McNeil, Xiaoli Zhang, Malith Karunasiri, Rohan Kulkarni, Sonu Kalyan, Dimitrios Papaioannou, Gregory Ferenchak, Ramiro Garzon, James E. Bradner, Guido Marcucci, Michael A. Caligiuri, Adrienne M. Dorrance

https://doi.org/10.3324/haematol.2020.271627

Low incidence of COVID-19 severe complications in a large cohort of children with sickle cell disease: a protective role for basal interferon-1 activation? (388 Online Views)

Valentine Brousse, Laurent Holvoet, Rémi Pescarmona, Sebastien Viel, Magali Perret, Benoit Visseaux, Valentine Marie Ferre, Ghislaine Ithier, Caroline Le Van Kim, Malika Benkerrou, Florence Missud, Berengere Koehl

https://doi.org/10.3324/haematol.2021.278573

May 6, 2021

Editorials
Article

MAP-kinase and JAK-STAT pathways dysregulation in plasmablastic lymphoma (614 Online Views)

Joan Enric Ramis-Zaldivar, Blanca Gonzalez-Farre, Alina Nicolae, Svetlana Pack, Guillem Clot, Ferran Nadeu, Anja Mottok, Heike Horn, Joo Y Song, Kai Fu, George Wright, Randy D. Gascoyne, Wing C. Chan, David W. Scott, Andrew L. Feldman, Alexandra Valera, Anna Enjuanes, Rita M. Braziel, Erlend B. Smeland, Louis M. Staudt, Andreas Rosenwald, Lisa M. Rimsza, German Ott, Elaine S Jaffe, Itziar Salaverria, Elias Campo

https://doi.org/10.3324/haematol.2020.271957

Articles

IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation (575 Online Views)

Pablo Peña-Martínez, Ramprasad Ramakrishnan, Carl Högberg, Caroline Jansson, David Gisselsson Nord, Marcus Järås

https://doi.org/10.3324/haematol.2020.270421

Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis (610 Online Views)

Yago Nieto, Stephen Gruschkus, Benigno C Valdez, Roy B Jones, Paolo Anderlini, Chitra Hosing, Uday Popat, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Neeraj Saini, Samer Srour, Katayoun Rezvani, Jeremy Ramdial, Melissa Barnett, Alison Gulbis, Terri Lynn Shigle, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Simrit Parmar, Raphael Steiner, Bouthaina Dabaja, Chelsea Pinnix, Jillian Gunther, Branko Cuglievan, Kris Mahadeo, Sajad Khazal, Hubert Chuang, Richard Champlin, Elizabeth J Shpall, Borje S Andersson

https://doi.org/10.3324/haematol.2021.278311

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome (443 Online Views)

Katia Todoerti, Domenica Ronchetti, Vanessa Favasuli, Francesco Maura, Fortunato Morabito, Niccolò Bolli, Elisa Taiana, Antonino Neri

https://doi.org/10.3324/haematol.2021.278342

Apr 29, 2021

Editorials
Article

Carfilzomib or bortezomib in combination with cyclophosphamide and dexamethasone followed by carfilzomib maintenance for patients with multiple myeloma after one prior therapy: results from a multi-centre, phase II, randomized, controlled trial (MUKfive) (556 Online Views)

Kwee L. Yong, Samantha Hinsley, Holger W. Auner, Ceri Bygrave, Martin F. Kaiser, Karthik Ramasamy, Ruth M. de Tute, Debbie Sherratt, Louise Flanagan, Mamta Garg, Stephen Hawkins, Catherine Williams, Jamie Cavenagh, Neil K. Rabin, James Croft, Gareth Morgan, Faith Davies, Roger G. Owen, Sarah R. Brown

https://doi.org/10.3324/haematol.2021.278399

Editorials
Article

Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag (1007 Online Views)

Yoshitaka Zaimoku, Bhavisha A. Patel, Ruba Shalhoub, Emma M. Groarke, Xingmin Feng, Colin O. Wu, Neal S. Young

https://doi.org/10.3324/haematol.2021.278413

Articles

LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia (681 Online Views)

Gabriel Gracia-Maldonado, Jason Clark, Matthew Burwinkel, Brenay Greenslade, Mark Wunderlich, Nathan Salomonis, Dario Leone, Evelina Gatti, Philippe Pierre, Ashish R. Kumar, Lynn H. Lee

https://doi.org/10.3324/haematol.2020.257451

Letters to the Editor

Apr 22, 2021

Editorials
Article

Evolutionary clonal trajectories in nodular lymphocyte predominant Hodgkin lymphoma with high transformation risk (450 Online Views)

Lisa Paschold, Edith Willscher, Julia Bein, Martine Vornanen, Dennis A. Eichenauer, Donjete Simnica, Benjamin Thiele, Claudia Wickenhauser, Andreas Rosenwald, Heinz-Wolfram Bernd, Wolfram Klapper, Alfred C. Feller, German Ott, Falko Fend, Sylvia Hartmann, Mascha Binder

https://doi.org/10.3324/haematol.2021.278427

Review Articles

Articles

Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy (340 Online Views)

Valentine Brousse, Corinne Pondarre, Manoelle Kossorotoff, Cecile Arnaud, Annie Kamdem, Mariane de Montalembert, Benedicte Boutonnat-Faucher, Slimane Allali, Hélène Bourdeau, Keyne Charlot, Sebastien Bertil, Lydie da Costa, Philippe Connes, David Grévent, Suzanne Verlhac

https://doi.org/10.3324/haematol.2020.278226

Clinical diagnostic value of telomere length measurement in inherited bone marrow failure syndromes (499 Online Views)

Shunsuke Miwata, Atsushi Narita, Yusuke Okuno, Kyogo Suzuki, Motoharu Hamada, Taro Yoshida, Masayuki Imaya, Ayako Yamamori, Manabu Wakamatsu, Kotaro Narita, Hironobu Kitazawa, Daisuke Ichikawa, Rieko Taniguchi, Nozomu Kawashima, Eri Nishikawa, Nobuhiro Nishio, Seiji Kojima, Hideki Muramatsu, Yoshiyuki Takahashi

https://doi.org/10.3324/haematol.2021.278334

Letters to the Editor

Survival and causes of death in 2033 patients with non-transfusion-dependent β-thalassemia (532 Online Views)

Khaled M. Musallam, Angela Vitrano, Antonella Meloni, Walter Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio

https://doi.org/10.3324/haematol.2021.278684

Apr 15, 2021

Articles

Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia (845 Online Views)

Dan Cojocari, Brianna N Smith, Julie J. Purkal, Maria P. Arrate, Jason D. Huska, Yu Xiao, Agnieszka Gorska, Leah J. Hogdal, Haley E. Ramsey, Erwin R Boghaert, Darren C. Phillips, Michael R. Savona

https://doi.org/10.3324/haematol.2020.272609

Case Reports

Apr 8, 2021

Editorials
Letter to the Editor

Heritability and association with distinct genetic loci of erythropoietin levels in the general population (374 Online Views)

Tanguy Corre, Belen Ponte, Edward Pivin, Menno Pruijm, Daniel Ackermann, Georg Ehret, Katharina Spanaus, Murielle Bochud, Roland H. Wenger

https://doi.org/10.3324/haematol.2021.278389

Articles

Letters to the Editor

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality (653 Online Views)

Rebecca J. Shaw, Simon T. Abrams, James Austin, Joseph M. Taylor, Steven Lane, Tina Dutt, Colin Downey, Min Du, Lance Turtle, J. Kenneth Baillie, Peter J.M. Openshaw, Guozheng Wang, Malcolm G. Semple, Cheng-Hock Toh

https://doi.org/10.3324/haematol.2021.278492

Apr 1, 2021

Articles

Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (914 Online Views)

Armando N. Bastidas Torres, Davy Cats, Jacoba J. Out-Luiting, Daniele Fanoni, Hailiang Mei, Luigia Venegoni, Rein Willemze, Maarten H. Vermeer, Emilio Berti, Cornelis P. Tensen

https://doi.org/10.3324/haematol.2020.274506

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma (1003 Online Views)

Man Chun John Ma, Saber Tadros, Alyssa Bouska, Tayla Heavican, Haopeng Yang, Qing Deng, Dalia Moore, Ariz Akhter, Keenan Hartert, Neeraj Jain, Jordan Showell, Sreejoyee Ghosh, Lesley Street, Marta Davidson, Christopher Carey, Joshua Tobin, Deepak Perumal, Julie M. Vose, Matthew A. Lunning, Aliyah R. Sohani, Benjamin J. Chen, Shannon Buckley, Loretta J. Nastoupil, R. Eric Davis, Jason R. Westin, Nathan H. Fowler, Samir Parekh, Maher Gandhi, Sattva Neelapu, Douglas Stewart, Kapil Bhalla, Javeed Iqbal, Timothy Greiner, Scott J. Rodig, Adnan Mansoor, Michael R. Green

https://doi.org/10.3324/haematol.2020.274258

Mar 25, 2021

Articles

Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance (565 Online Views)

Soracha E. Ward, Jamie M. O’Sullivan, Alan B. Moran, Daniel I. R. Spencer, Richard A. Gardner, Jyotika Sharma, Judicael Fazavana, Marco Monopoli, Thomas A.J. McKinnon, Alain Chion, Sandra Haberichter, James S. O’Donnell

https://doi.org/10.3324/haematol.2020.274720

Letters to the Editor

Prognostic impact of soluble CD163 in patients with diffuse large B-cell lymphoma (593 Online Views)

Heli Vajavaara, Frida Ekeblad, Harald Holte, Judit Jorgensen, Suvi-Katri Leivonen, Mattias Berglund, Peter Kamper, Holger J. Moller, Francesco d’Amore, Daniel Molin, Gunilla Enblad, Maja Ludvigsen, Ingrid Glimelius, Sirpa Leppa

https://doi.org/10.3324/haematol.2020.278182

Mar 18, 2021

Editorials
Article

Phase 2 study of acalabrutinib in ibrutinib-intolerant patients with relapsed/refractory chronic lymphocytic leukemia (2208 Online Views)

Kerry A. Rogers, Philip A. Thompson, John N. Allan, Morton Coleman, Jeff P. Sharman, Bruce D. Cheson, Daniel Jones, Raquel Izumi, Melanie M. Frigault, Cheng Quah, Rakesh K. Raman, Priti Patel, Min Hui Wang, Thomas J. Kipps

https://doi.org/10.3324/haematol.2020.272500

Articles

β-thalassemia minor is a beneficial determinant of red blood cell storage lesion (554 Online Views)

Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Davide Stefanoni, Francesca Cendali, Lorenzo Bertolone, Fabia Gamboni, Monika Dzieciatkowska, Pantelis Rousakis, Athina Vergaki, Vassilis Soulakis, Ourania E. Tsitsilonis, Konstantinos Stamoulis, Issidora S. Papassideri, Anastasios G. Kriebardis, Angelo D’Alessandro, Marianna H. Antonelou

https://doi.org/10.3324/haematol.2020.273946

Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia (862 Online Views)

Taeko Kaburagi, Genki Yamato, Norio Shiba, Kenichi Yoshida, Yusuke Hara, Ken Tabuchi, Yuichi Shiraishi, Kentaro Ohki, Manabu Sotomatsu, Hirokazu Arakawa, Hidemasa Matsuo, Akira Shimada, Tomohiko Taki, Nobutaka Kiyokawa, Daisuke Tomizawa, Keizo Horibe, Satoru Miyano, Takashi Taga, Souichi Adachi, Seishi Ogawa, Yasuhide Hayashi

https://doi.org/10.3324/haematol.2020.269431

Integrative prognostic models predict long-term survival after immunochemotherapy in chronic lymphocytic leukemia patients (473 Online Views)

Johannes Bloehdorn, Julia Krzykalla, Karlheinz Holzmann, Andreas Gerhardinger, Billy Michael Chelliah Jebaraj, Jasmin Bahlo, Kathryn Humphrey, Eugen Tausch, Sandra Robrecht, Daniel Mertens, Christof Schneider, Kirsten Fischer, Michael Hallek, Hartmut Döhner, Axel Benner, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2020.251561

Mar 11, 2021

Articles

Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients (560 Online Views)

Silvia Ramos-Campoy, Anna Puiggros, Sílvia Beà, Sandrine Bougeon, María José Larráyoz, Dolors Costa, Helen Parker, Gian Matteo Rigolin, Margarita Ortega, María Laura Blanco, Rosa Collado, Rocío Salgado, Tycho Baumann, Eva Gimeno, Carolina Moreno, Francesc Bosch, Xavier Calvo, María José Calasanz, Antonio Cuneo, Jonathan C. Strefford, Florence Nguyen-Khac, David Oscier, Claudia Haferlach, Jacqueline Schoumans, Blanca Espinet

https://doi.org/10.3324/haematol.2020.274456

Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune)therapy (611 Online Views)

Marc Zapatka, Eugen Tausch, Selcen Öztürk, Deyan Yordanov Yosifov, Martina Seiffert, Thorsten Zenz, Christof Schneider, Johannes Blöhdorn, Hartmut Döhner, Daniel Mertens, Peter Lichter, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2020.265777

ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells (581 Online Views)

Vikas Madan, Zeya Cao, Weoi Woon Teoh, Pushkar Dakle, Lin Han, Pavithra Shyamsunder, Maya Jeitany, Siqin Zhou, Jia Li, Hazimah Binte Mohd Nordin, JiZhong Shi, Shuizhou Yu, Henry Yang, Md Zakir Hossain, Wee Joo Chng, H. Phillip Koeffler

https://doi.org/10.3324/haematol.2020.260562

Feb 25, 2021

Articles

Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia (639 Online Views)

Eun-Ji Choi, Young-Uk Cho, Eun-Hye Hur, Seongsoo Jang, Nayoung Kim, Han-Seung Park, Jung-Hee Lee, Kyoo-Hyung Lee, Si-Hwan Kim, Sang-Hyun Hwang, Eul-Ju Seo, Chan-Jeoung Park, Je-Hwan Lee

https://doi.org/10.3324/haematol.2020.270553

Feb 18, 2021

Articles

Identification of a novel genetic locus associated with immune mediated thrombotic thrombocytopenic purpura (521 Online Views)

Matthew J. Stubbs, Paul Coppo, Chris Cheshire, Agnès Veyradier, Stephanie Dufek, Adam P. Levine, Mari Thomas, Vaksha Patel, John O. Connolly, Michael Hubank, Ygal Benhamou, Lionel Galicier, Pascale Poullin, Robert Kleta, Daniel P. Gale, Horia Stanescu, Marie A Scully

https://doi.org/10.3324/haematol.2020.274639

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma (1061 Online Views)

Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E. Robinson, Valentina S. Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W. Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris

https://doi.org/10.3324/haematol.2020.274480

The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia (607 Online Views)

Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak

https://doi.org/10.3324/haematol.2020.263756

Feb 11, 2021

Articles

Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia (729 Online Views)

Marion K. Mateos, Glenn M. Marshall, Pasquale M. Barbaro, Michael C.J. Quinn, Carly George, Chelsea Mayoh, Rosemary Sutton, Tamas Revesz, Jodie E. Giles, Draga Barbaric, Frank Alvaro, Françoise Mechinaud, Daniel Catchpoole, John A. Lawson, Georgia Chenevix-Trench, Stuart MacGregor, Rishi S. Kotecha, Luciano Dalla-Pozza, Toby N. Trahair

https://doi.org/10.3324/haematol.2020.268565

Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes (677 Online Views)

Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Giovanni A.M. Povoleri, Jessica A. Timms, Shahram Kordasti, Tanja D. de Gruijl, Arjan A. van de Loosdrecht

https://doi.org/10.3324/haematol.2020.268136

Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis (808 Online Views)

Rachel Dobson, Peter Y. Du, Lívia Rásó-Barnett, Wen-Qing Yao, Zi Chen, Calogero Casa, Hesham EI-Daly, Lorant Farkas, Elizabeth Soilleux, Penny Wright, John W. Grant, Manuel Rodriguez-Justo, George A. Follows, Hala Rashed, Margarete Fabre, E. Joanna Baxter, George Vassiliou, Andrew Wotherspoon, Ayoma D. Attygalle, Hongxiang Liu, Ming-Qing Du

https://doi.org/10.3324/haematol.2020.265991

Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates (1068 Online Views)

Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano Jr.

https://doi.org/10.3324/haematol.2020.260059

Jan 21, 2021

Articles

Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation (412 Online Views)

Michela Faleschini, Nicole Papa, Marie-Christine Morel-Kopp, Caterina Marconi, Tania Giangregorio, Federica Melazzini, Valeria Bozzi, Marco Seri, Patrizia Noris, Alessandro Pecci, Anna Savoia, Roberta Bottega

https://doi.org/10.3324/haematol.2020.267328

Jan 14, 2021

Articles

Long term follow-up of pediatric-onset Evans syndrome: broad immunopathological manifestations and high treatment burden (623 Online Views)

Thomas Pincez, Helder Fernandes, Thierry Leblanc, Gérard Michel, Vincent Barlogis, Yves Bertrand, Bénédicte Neven, Wadih Abou Chahla, Marlène Pasquet, Corinne Guitton, Aude Marie-Cardine, Isabelle Pellier, Corinne Armari-Alla, Joy Benadiba, Pascale Blouin, Eric Jeziorski, Frédéric Millot, Catherine Paillard, Caroline Thomas, Nathalie Cheikh, Sophie Bayart, Fanny Fouyssac, Christophe Piguet, Marianna Deparis, Claire Briandet, Eric Dore, Capucine Picard, Frédéric Rieux-Laucat, Judith Landman-Parker, Guy Leverger, Nathalie Aladjidi

https://doi.org/10.3324/haematol.2020.271106

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity (1562 Online Views)

Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger

https://doi.org/10.3324/haematol.2020.269670

Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector (1122 Online Views)

Yang Liu, Maria Dahl, Shubhranshu Debnath, Michael Rothe, Emma M. Smith, Tan Hooi Min Grahn, Sarah Warsi, Jun Chen, Johan Flygare, Axel Schambach, Stefan Karlsson

https://doi.org/10.3324/haematol.2020.269142

Human invariant natural killer T cells promote tolerance by preferential apoptosis induction of conventional dendritic cells (494 Online Views)

Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind

https://doi.org/10.3324/haematol.2020.267583

Jan 7, 2021

Articles

Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multicentre nation-wide cohort (752 Online Views)

Maddalena Casale, Gian Luca Forni, Elena Cassinerio, Daniela Pasquali, Raffaella Origa, Marilena Serra, Saveria Campisi, Angelo Peluso, Roberta Renni, Alessandro Cattoni, Elisa De Michele, Massimo Allò, Maurizio Poggi, Francesca Ferrara, Rosanna Di Concilio, Filomena Sportelli, Antonella Quarta, Maria Caterina Putti, Lucia Dora Notarangelo, Antonella Sau, Saverio Ladogana, Immacolata Tartaglione, Stefania Picariello, Alessia Marcon, Patrizia Sturiale, Domenico Roberti, Antonio Ivan Lazzarino, Silverio Perrotta

https://doi.org/10.3324/haematol.2020.272419

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia. (1859 Online Views)

Rudy Birsen, Clement Larrue, Justine Decroocq, Natacha Johnson, Nathan Guiraud, Mathilde Gotanegre, Lilia Cantero-Aguilar, Eric Grignano, Tony Huynh, Michaela Fontenay, Olivier Kosmider, Patrick Mayeux, Nicolas Chapuis, Jean Emmanuel Sarry, Jerome Tamburini, Didier Bouscary

https://doi.org/10.3324/haematol.2020.259531

Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance (689 Online Views)

Martina Moras, Claude Hattab, Pedro Gonzalez-Menendez, Claudio M. Fader, Michael Dussiot, Jerome Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi Taylor, Sophie D. Lefevre, Mariano A. Ostuni

https://doi.org/10.3324/haematol.2020.257121

Dec 30, 2020

Articles

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide. (2265 Online Views)

Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer

https://doi.org/10.3324/haematol.2020.271908

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis (983 Online Views)

Thomas Milan, Magalie Celton, Karine Lagacé, Élodie Roques, Safia Safa-Tahar-Henni, Eva Bresson, Anne Bergeron, Josée Hebert, Soheil Meshinchi, Sonia Cellot, Frédéric Barabé, Brian T Wilhelm

https://doi.org/10.3324/haematol.2020.271619

Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia (901 Online Views)

Anna Hecht, Julia A. Meyer, Astrid Behnert, Eric Wong, Farid Chehab, Adam Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat, Jason E. Farrar, Mark Fluchel, Haydar Frangoul, Jennifer H. Han, Edward A. Kolb, Dennis J. Kuo, Margaret L. MacMillan, Luke Maese, Kelly W. Maloney, Aru Narendran, Benjamin Oshrine, Kirk R. Schultz, Maria L. Sulis, David Van Mater, Sarah K. Tasian, Wolf-Karsten Hofmann, Mignon L. Loh, Elliot Stieglitz

https://doi.org/10.3324/haematol.2020.270595

Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia (1096 Online Views)

Alisa Damnernsawad, Daniel Bottomly, Stephen E. Kurtz, Christopher A. Eide, Shannon K. McWeeney, Jeffrey W. Tyner, Tamilla Nechiporuk

https://doi.org/10.3324/haematol.2020.257964

Dec 23, 2020

Articles

Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and resensitizes acute myeloid leukemia to BCL-2 inhibition (1161 Online Views)

Bing Z. Carter, Po Yee Mak, Wenjing Tao, Marc Warmoes, Philip L. Lorenzi, Duncan Mak, Vivian Ruvolo, Lin Tan, Justin Cidado, Lisa Drew, Michael Andreeff

https://doi.org/10.3324/haematol.2020.260331

Dec 17, 2020

Articles

Baseline SUVmax is related to tumor cell proliferation and patient outcome in follicular lymphoma (861 Online Views)

Cédric Rossi, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, Don-Marc Franchini, Nadia Amara, Charlotte Syrykh, Pierre Bories, Lucie Oberic, Loïc Ysebaert, Laurent Martin, Selim Ramla, Philippine Robert, Claire Tabouret-Viaud, René-Olivier Casasnovas, Jean-Jacques Fournié, Christine Bezombes, Camille Laurent

https://doi.org/10.3324/haematol.2020.263194

Post-translational polymodification of β1-tubulin regulates motor protein localisation in platelet production and function (688 Online Views)

Abdullah O. Khan, Alexandre Slater, Annabel Maclachlan, Phillip L.R. Nicolson, Jeremy A. Pike, Jasmeet S. Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G. Thomas, Neil V. Morgan

https://doi.org/10.3324/haematol.2020.270793

Dec 10, 2020

Articles

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway (908 Online Views)

Tongjie Wang, Chengxiang Xia, Qitong Weng, Kaitao Wang, Yong Dong, Sha Hao, Fang Dong, Xiaofei Liu, Lijuan Liu, Yang Geng, Yuxian Guan, Juan Du, Tao Cheng, Hui Cheng, Jinyong Wang

https://doi.org/10.3324/haematol.2019.239186

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia (711 Online Views)

Alaeddin Khalil, Gudrun Würthwein, Jana Golitsch, Georg Hempel, Manfred Fobker, Joachim Gerss, Anja Möricke, Martin Zimmermann, Petr Smisek, Massimo Zucchetti, Christa Nath, Andishe Attarbaschi, Arend von Stackelberg, Nicola Gökbuget, Carmelo Rizzari, Valentino Conter, Martin Schrappe, Joachim Boos, Claudia Lanvers-Kaminsky

https://doi.org/10.3324/haematol.2020.258525

Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential (703 Online Views)

Lennart Raman, Malaïka Van der Linden, Ciel De Vriendt, Bliede Van den Broeck, Kristoff Muylle, Dries Deeren, Franceska Dedeurwaerdere, Sofie Verbeke, Amélie Dendooven, Katrien De Grove, Saskia Baert, Kathleen Claes, Björn Menten, Fritz Offner, Jo Van Dorpe

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Dec 3, 2020

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Phenogenomic heterogeneity of post-transplant plasmablastic lymphomas (636 Online Views)

Rebecca J. Leeman-Neill, Craig R. Soderquist, Francesca Montanari, Patricia Raciti, David Park, Dejan Radeski, Mahesh M. Mansukhani, Vundavalli V. Murty, Susan Hsiao, Bachir Alobeid, Govind Bhagat

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Autologous stem cell transplantation is safe and effective for fit older myeloma patients: exploratory results from the Myeloma XI trial (753 Online Views)

Charlotte Pawlyn, David Cairns, Tom Menzies, John Jones, Matthew Jenner, Gordon Cook, Kevin Boyd, Mark Drayson, Martin Kaiser, Roger Owen, Walter Gregory, Gareth Morgan, Graham Jackson, Faith Davies

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Nov 26, 2020

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Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis (983 Online Views)

Sheila Bohler, Sehar Afreen, Juncal Fernandez-Orth, Eva-Maria Demmerath, Christian Molnar, Ying Wu, Julia Miriam Weiss, Venugopal Rao Mittapalli, Lukas Konstantinidis, Hagen Schmal, Mirjam Kunze, Miriam Erlacher

https://doi.org/10.3324/haematol.2020.252130

The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion (726 Online Views)

Audrey Astori, Gabriel Matherat, Isabelle Munoz, Emilie-Fleur Gautier, Didier Surdez, Yaël Zermati, Frédérique Verdier, Sakina Zaidi, Vincent Feuillet, Amir Kadi, Evelyne Lauret, Olivier Delattre, Carine Lefèvre, Michaela Fontenay, Evelyne Ségal-Bendirdjian, Isabelle Dusanter-Fourt, Didier Bouscary, Olivier Hermine, Patrick Mayeux, Frédéric Pendino

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Nov 19, 2020

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Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells (663 Online Views)

Sandra Romero Marquez, Franziska Hettler, Renate Hausinger, Christina Schreck, Theresa Landspersky, Lynette Henkel, Corinne Angerpointner, Ihsan E. Demir, Matthias Schiemann, Florian Bassermann, Katharina S. Götze, Rouzanna Istvánffy, Robert A.J. Oostendorp

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Bone marrow megakaryocytic activation predicts fibrotic evolution of Philadelphia-negative myeloproliferative neoplasms (1161 Online Views)

Mattia Schino, Vincenzo Fiorentino, Elena Rossi, Silvia Betti, Monica Di Cecca, Valentina Ranucci, Patrizia Chiusolo, Maurizio Martini, Valerio De Stefano, Luigi Maria Larocca

https://doi.org/10.3324/haematol.2020.264143

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways (691 Online Views)

Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling

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Nov 12, 2020

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A prognostic index predicting survival in transformed Waldenström macroglobulinemia (1042 Online Views)

Eric Durot, Lukshe Kanagaratnam, Saurabh Zanwar, Efstathios Kastritis, Shirley D’Sa, Ramon Garcia-Sanz, Cécile Tomowiak, Bénédicte Hivert, Elise Toussaint, Caroline Protin, Jithma P. Abeykoon, Thomas Guerrero-Garcia, Gilad Itchaki, Josephine M. Vos, Anne-Sophie Michallet, Sophie Godet, Jehan Dupuis, Stéphane Leprêtre, Joshua Bomsztyk, Pierre Morel, Véronique Leblond, Steven P. Treon, Meletios A. Dimopoulos, Prashant Kapoor, Alain Delmer, Jorge J. Castillo

https://doi.org/10.3324/haematol.2020.262899

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Claudia Sargas, Rosa Ayala, María Carmen Chillón, María J. Larráyoz, Estrella Carrillo-Cruz, Cristina Bilbao, Manuel Yébenes-Ramírez, Marta Llop, Inmaculada Rapado, Ramón García-Sanz, Iria Vázquez, Elena Soria, Yanira Florido-Ortega, Kamila Janusz, Carmen Botella, Josefina Serrano, David Martínez-Cuadrón, Juan Bergua, Mari Luz Amigo, Pilar Martínez-Sánchez, Mar Tormo, Teresa Bernal, Pilar Herrera-Puente, Raimundo García, Lorenzo Algarra, María J. Sayas, Lisette Costilla-Barriga, Esther Pérez-Santolalla, Inmaculada Marchante, Esperanza Lavilla-Rubira, Víctor Noriega, Juan M. Alonso-Domínguez, Miguel Á. Sanz, Joaquín Sánchez-Garcia, María T. Gómez-Casares, José A. Pérez-Simón, María J. Calasanz, Marcos González-Díaz, Joaquín Martínez-López, Eva Barragán, Pau Montesinos

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Nov 5, 2020

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PVRIG is a novel NK cell immune checkpoint receptor in acute myeloid leukemia (1926 Online Views)

Jessica Li, Sarah Whelan, Maya F. Kotturi, Deborah Meyran, Criselle D’Souza, Kyle Hansen, Spencer Liang, John Hunter, Joseph A. Trapani, Paul J. Neeson

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Željko Antić, Jiangyan Yu, Simon V. van Reijmersdal, Anke van Dijk, Linde Dekker, Wouter H. Segerink, Edwin Sonneveld, Marta Fiocco, Rob Pieters, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Ad Geurts van Kessel, Esme Waanders, Roland P. Kuiper

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Mara N. Zeissig, Duncan R. Hewett, Vasilios Panagopoulos, Krzysztof M. Mrozik, L. Bik To, Peter I. Croucher, Andrew C.W. Zannettino, Kate Vandyke

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Oct 29, 2020

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Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities (740 Online Views)

Caroline Scott, Damien J. Downes, Jill M. Brown, Robert Beagrie, Aude-Anais Olijnik, Matthew Gosden, Ron Schwessinger, Christopher A. Fisher, Anna Rose, David J.P Ferguson, Errin Johnson, Quentin A. Hill, Steven Okoli, Raffaele Renella, Kate Ryan, Marjorie Brand, Jim Hughes, Noemi B.A. Roy, Douglas R. Higgs, Christian Babbs, Veronica J. Buckle

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Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria (1501 Online Views)

Antonio M. Risitano, Austin G. Kulasekararaj, Jong Wook Lee, Jaroslaw P. Maciejewski, Rosario Notaro, Robert Brodsky, Mingjun Huang, Michael Geffner, Peter Browett

https://doi.org/10.3324/haematol.2020.261826

Use of the HLA-B leader to optimize cord-blood transplantation (686 Online Views)

Effie W. Petersdorf, Ted Gooley, Fernanda Volt, Chantal Kenzey, Alejandro Madrigal, Caroline McKallor, Sergio Querol, Hanadi Rafii, Vanderson Rocha, Ryad Tamouza, Christian Chabannon, Annalisa Ruggeri, Eliane Gluckman

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Venetoclax plus bendamustine-rituximab or bendamustine-obinutuzumab in chronic lymphocytic leukemia: final results of a phase 1b study (GO28440) (1263 Online Views)

Stephan Stilgenbauer, Franck Morschhauser, Clemens-Martin Wendtner, Guillaume Cartron, Michael Hallek, Barbara Eichhorst, Mark F. Kozloff, Thomas Giever, Gerard Lozanski, Yanwen Jiang, Huang Huang, Daniela Soriano Pignataro, William Schary, Kathryn Humphrey, Mehrdad Mobasher, Gilles Salles

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SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation (673 Online Views)

Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei

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Oct 13, 2020

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Zanubrutinib monotherapy for patients with treatment naïve chronic lymphocytic leukemia and 17p deletion (3679 Online Views)

Constantine S. Tam, Tadeusz Robak, Paolo Ghia, Brad S. Kahl, Patricia Walker, Wojciech Janowski, David Simpson, Mazyar Shadman, Peter S. Ganly, Luca Laurenti, Stephen Opat, Monica Tani, Hanna Ciepluch, Emma Verner, Martin Šimkovič, Anders Österborg, Marek Trněný, Alessandra Tedeschi, Jason C. Paik, Sowmya B. Kuwahara, Shibao Feng, Vanitha Ramakrishnan, Aileen Cohen, Jane Huang, Peter Hillmen, Jennifer R. Brown

https://doi.org/10.3324/haematol.2020.259432

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice (624 Online Views)

Manfred Nairz, Christoph Metzendorf, Maja Vujic-Spasic, Anna-Maria Mitterstiller, Andrea Schroll, David Haschka, Alexander Hoffmann, Laura von Raffay, Richard Sparla, Christian W. Huck, Heribert Talasz, Patrizia L. Moser, Martina U. Muckenthaler, Günter Weiss

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Loria Zalmaï, Pierre-Julien Viailly, Sabeha Biichle, Meyling Cheok, Lou Soret, Fanny Angelot-Delettre, Tony Petrella, Marie-Agnès Collonge-Rame, Estelle Seilles, Sandrine Geffroy, Eric Deconinck, Etienne Daguindau, Sabrina Bouyer, Elodie Dindinaud, Victor Baunin, Magali Le Garff-Tavernier, Damien Roos-Weil, Orianne Wagner-Ballon, Véronique Salaun, Jean Feuillard, Sophie Brun, Bernard Drenou, Caroline Mayeur-Rousse, Patricia Okamba, Véronique Dorvaux, Michel Tichionni, Johann Rose, Marie Thérèse Rubio, Marie Christine Jacob, Victoria Raggueneau, Claude Preudhomme, Philippe Saas, Christophe Ferrand, Olivier Adotevi, Christophe Roumier, Fabrice Jardin, Francine Garnache-Ottou, Florian Renosi

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Oct 5, 2020

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Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans (855 Online Views)

Daniel C.J. Ferguson, Juraidah Haji Mokim, Marjolein Meinders, Edmund R.R. Moody, Tom A. Williams, Sarah Cooke, Kongtana Trakarnsanga, Deborah E. Daniels, Ivan Ferrer-Vicens, Deborah Shoemark, Chartsiam Tipgomut, Katherine A. Macinnes, Marieangela C. Wilson, Belinda K. Singleton, Jan Frayne

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Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration (1818 Online Views)

Deborah M. Stephens, Ken Boucher, Elizabeth Kander, Sameer A. Parikh, Erin M. Parry, Mazyar Shadman, John M. Pagel, Jennifer Cooperrider, Joanna Rhodes, Anthony Mato, Allison Winter, Brian Hill, Sameh Gaballa, Alexey Danilov, Tycel Phillips, Danielle M. Brander, Sonali M. Smith, Matthew Davids, Kerry Rogers, Martha J. Glenn, John C. Byrd

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Sep 28, 2020

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Engineered type 1 regulatory T cells designed for clinical use kill primary pediatric acute myeloid leukemia cells (987 Online Views)

Brandon Cieniewicz, Molly Javier Uyeda, Ping (Pauline) Chen, Ece Canan Sayitoglu, Jeffrey Mao-Hwa Liu, Grazia Andolfi, Katharine Greenthal, Alice Bertaina, Silvia Gregori, Rosa Bacchetta, Norman James Lacayo, Alma-Martina Cepika, Maria Grazia Roncarolo

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Platelet proteome and function in X–linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome (1212 Online Views)

Daniel Bergemalm, Sofia Ramström, Caroline Kardeby, Kjell Hultenby, Anna Göthlin Eremo, Carina Sihlbom, Jörgen Bergström, Jan Palmblad, Maria Åström

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Sep 21, 2020

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Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro (896 Online Views)

Thomas Hoefer, Akshita Rana, Be'eri Niego, Shweta Jagdale, Hugo J. Albers, Elizabeth E. Gardiner, Robert K. Andrews, Andries D. Van der Meer, Christoph E. Hagemeyer, Erik Westein

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Sep 14, 2020

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Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma (1038 Online Views)

Youssef Youssef, Vrajesh Karkhanis, Wing Keung Chan, Frankie Jeney, Alessandro Canella, Xiaoli Zhang, Shelby Sloan, Alexander Prouty, JoBeth Helmig-Mason, Liudmyla Tsyba, Walter Hanel, Xuguang Zheng, Pu Zhang, Ji-Hyun Chung, David M. Lucas, Zachary Kauffman, Karilyn Larkin, Anne M. Strohecker, Hatice G. Ozer, Rosa Lapalombella, Hui Zhou, Zijun Y. Xu-Monette, Ken H. Young, Ruolan Han, Elmar Nurmemmedov, Gerard Nuovo, Kami Maddocks, John C. Byrd, Robert A. Baiocchi, Lapo Alinari

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The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis (710 Online Views)

Mahran Shoukier, Gautam Borthakur, Elias Jabbour, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Jairo Matthews, Lucia Masarova, Kiran Naqvi, Koji Sasaki, Srdan Verstovsek, Jorge Cortes

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Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations (895 Online Views)

Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak

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Sep 10, 2020

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CDKN2A deletion is a frequent event associated with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) (817 Online Views)

Francesco Maura, Anna Dodero, Cristiana Carniti, Niccolò Bolli, Martina Magni, Valentina Monti, Antonello Cabras, Daniel Leongamornlert, Federico Abascal, Benjamin Diamond, Bernardo Rodriguez-Martin, Jorge Zamora, Adam Butler, Inigo Martincorena, Jose M. C. Tubio, Peter J. Campbell, Annalisa Chiappella, Giancarlo Pruneri, Paolo Corradini

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Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells (520 Online Views)

Angelo D’Alessandro, Ariel Hay, Monika Dzieciatkowska, Benjamin C. Brown, Evan J Morrison, Kirk C. Hansen, James C Zimring

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Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency (754 Online Views)

Birgit van Dooijeweert, Melissa H. Broeks, Nanda M. Verhoeven-Duif, Eduard J. van Beers, Edward E.S. Nieuwenhuis, Wouter W. van Solinge, Marije Bartels, Judith J. Jans, Richard van Wijk

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Aug 27, 2020

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Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype (1262 Online Views)

Antonio Vogelsberg, Julia Steinhilber, Barbara Mankel, Birgit Federmann, Janine Schmidt, Ivonne A. Montes-Mojarro, Katrin Hüttl, Maria Rodriguez-Pinilla, Praveen Baskaran, Sven Nahnsen, Miguel A. Piris, German Ott, Leticia Quintanilla-Martinez, Irina Bonzheim, Falko Fend

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Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease (1113 Online Views)

Sara El Hoss, Sylvie Cochet, Auria Godard, Hongxia Yan, Michaël Dussiot, Giacomo Frati, Bénédicte Boutonnat-Faucher, Sandrine Laurance, Olivier Renaud, Laure Joseph, Annarita Miccio, Valentine Brousse, Mohandas Narla, Wassim El Nemer

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Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis: role of TNFα, IL-6 and IL-11 cytokines (755 Online Views)

Paolo Giannoni, Cecilia Marini, Giovanna Cutrona, Serena Matis, Maria Cristina Capra, Francesca Puglisi, Paola Luzzi, Simona Pigozzi, Gabriele Gaggero, Antonino Neri, Katia Todoerti, Fortunato Morabito, Adalberto Ibatici, Maurizio Miglino, Micaela Bergamaschi, Silvia Bruno, Gian Mario Sambuceti, Jean Louis Ravetti, Manlio Ferrarini, Franco Fais, Daniela de Totero

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Clinical significance of chromatin-spliceosome acute myeloid leukemia: a report from the Northern Italy Leukemia Group (NILG) randomized trial 02/06 (1110 Online Views)

Chiara Caprioli, Federico Lussana, Silvia Salmoiraghi, Roberta Cavagna, Ksenija Buklijas, Lara Elidi, Pamela Zanghi', Anna Michelato, Federica Delaini, Elena Oldani, Tamara Intermesoli, Anna Grassi, Giacomo Gianfaldoni, Francesco Mannelli, Dario Ferrero, Ernesta Audisio, Elisabetta Terruzzi, Lorella De Paoli, Chiara Cattaneo, Erika Borlenghi, Irene Cavattoni, Monica Tajana, Anna Maria Scattolin, Daniele Mattei, Paolo Corradini, Leonardo Campiotti, Fabio Ciceri, Massimo Bernardi, Elisabetta Todisco, Agostino Cortelezzi, Brunangelo Falini, Chiara Pavoni, Renato Bassan, Orietta Spinelli, Alessandro Rambaldi

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Combinatorial molecule screening identifies a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells (925 Online Views)

Simon Hultmark, Aurélie Baudet, Ludwig Schmiderer, Pavan Prabhala, Sara Palma-Tortosa, Carl Sandén, Thoas Fioretos, Rajkumar Sasidharan, Christer Larsson, Sören Lehmann, Gunnar Juliusson, Fredrik Ek, Mattias Magnusson

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Oxidative stress activates red cell adhesion to laminin in sickle cell disease (791 Online Views)

Maria Alejandra Lizarralde-Iragorri, Sophie D. Lefevre, Sylvie Cochet, Sara El Hoss, Valentine Brousse, Anne Filipe, Michael Dussiot, Slim Azouzi, Caroline Le Van Kim, Fernando Rodrigues-Lima, Olivier Français, Bruno Le Pioufle, Thomas Klei, Robin van Bruggen, Wassim El Nemer

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Aug 13, 2020

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Matthieu Mahévas, Imane Azzaoui, Etienne Crickx, Florence Canoui-Poitrine, Delphine Gobert, Laetitia Languille, Nicolas Limal, Constance Guillaud, Laure Croisille, Mohamed Jeljeli, Fréderic Batteux, Samia Baloul, Olivier Fain, France Pirenne, Jean-Claude Weill, Claude-Agnès Reynaud, Bertrand Godeau, Marc Michel

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A 3-gene signature based on MYC, BCL-2 and NFKBIA improves risk stratification in diffuse large B-cell lymphoma (829 Online Views)

Enrico Derenzini, Saveria Mazzara, Federica Melle, Giovanna Motta, Marco Fabbri, Riccardo Bruna, Claudio Agostinelli, Alessandra Cesano, Chiara Antonia Corsini, Ning Chen, Simona Righi, Elena Sabattini, Annalisa Chiappella, Angelica Calleri, Stefano Fiori, Valentina Tabanelli, Antonello Cabras, Giancarlo Pruneri, Umberto Vitolo, Alessandro Massimo Gianni, Alessandro Rambaldi, Paolo Corradini, Pier Luigi Zinzani, Corrado Tarella, Stefano Pileri

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Jul 30, 2020

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Impaired nodal shrinkage and apoptosis define the independent adverse outcome of NOTCH1 mutated patients under ibrutinib therapy in chronic lymphocytic leukaemia (486 Online Views)

Giovanni Del Poeta, Annalisa Biagi, Luca Laurenti, Annalisa Chiarenza, Federico Pozzo, Idanna Innocenti, Massimiliano Postorino, Francesca Maria Rossi, Maria Ilaria Del Principe, Riccardo Bomben, Paolo de Fabritiis, Antonio Bruno, Maria Cantonetti, Francesco Di Raimondo, Antonella Zucchetto, Valter Gattei

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3D co-culture model of chronic lymphocytic leukemia bone marrow microenvironment predicts patient-specific response to mobilizing agents (813 Online Views)

Federica Barbaglio, Daniela Belloni, Lydia Scarfò, Francesca Vittoria Sbrana, Maurilio Ponzoni, Lucia Bongiovanni, Luca Pavesi, Desiree Zambroni, Kostas Stamatopoulos, Valeria R. Caiolfa, Elisabetta Ferrero, Paolo Ghia, Cristina Scielzo

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Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1 (790 Online Views)

Gehong Dong, Yuping Li, Logan Lee, Xuxiang Liu, Yunfei Shi, Xiaoqian Liu, Alyssa Bouska, Qiang Gong, Lingbo Kong, Jinhui Wang, Chih-Hong Lou, Timothy W. McKeithan, Javeed Iqbal, Wing C. Chan

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Effect of HBB genotype on survival in a cohort of transfusion-dependent thalassemia patients in Cyprus (442 Online Views)

Petros Kountouris, Kyriaki Michailidou, Soteroula Christou, Michael Hadjigavriel, Maria Sitarou, Anita Kolnagou, Marina Kleanthous, Paul Telfer

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Elastography improves accuracy of early hepato-biliary complications diagnosis after allogeneic stem cell transplantation (577 Online Views)

Pierre-Edouard Debureaux, Pierre Bourrier, Pierre-Emmanuel Rautou, Anne-Marie Zagdanski, Morgane De Boutiny, Simona Pagliuca, Aurélien Sutra Del Galy, Marie Robin, Régis Peffault de Latour, Aurélie Plessier, Flore Sicre de Fontbrune, Aliénor Xhaard, Pedro Henrique de Lima Prata, Dominique Valla, Gérard Socié, David Michonneau

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Altered T-cell subset repertoire affects treatment outcome of patients with myelofibrosis (460 Online Views)

Ivo Veletic, Sanja Prijic, Taghi Manshouri, Graciela M. Nogueras-Gonzalez, Srdan Verstovsek, Zeev Estrov

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Hematopoietic recovery and immune reconstitution after axicabtagene ciloleucel in patients with large B-cell lymphoma (1559 Online Views)

Paolo Strati, Ankur Varma, Sherry Adkins, Loretta J. Nastoupil, Jason Westin, Fredrick B. Hagemeister, Nathan H. Fowler, Hun J. Lee, Luis E. Fayad, Felipe Samaniego, Sairah Ahmed, Yiming Chen, Sandra Horowitz, Sara Arafat, Swapna Johncy, Partow Kebriaei, Victor Eduardo Mulanovich, Ella Ariza Heredia, Sattva S. Neelapu

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Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse (906 Online Views)

Esther Onecha, Inmaculada Rapado, María Luz Morales, Gonzalo Carreño-Tarragona, Pilar Martinez-Sanchez, Xabier Gutierrez, José María Sáchez Pina, María Linares, Miguel Gallardo, Joaquín Martinez-López, Rosa Ayala

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Dynamics of mutations in patients with essential thrombocythemia treated with imetelstat (812 Online Views)

Elisabeth Oppliger Leibundgut, Monika Haubitz, Bart Burington, Oliver G. Ottmann, Gary Spitzer, Olatoyosi Odenike, Michael A. McDevitt, Alexander Röth, David S. Snyder, Gabriela M. Baerlocher

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Jul 23, 2020

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Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating beta2 integrin clustering (671 Online Views)

Gabriele Zuchtriegel, Bernd Uhl, Robert Pick, Michaela Ramsauer, Julian Dominik, Laura A. Mittmann, Martin Canis, Sandip Kanse, Markus Sperandio, Fritz Krombach, Christoph A. Reichel

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Cell type specific novel lncRNAs and circRNAs in the BLUEPRINT haematopoietic transcriptomes atlas. (936 Online Views)

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May 10, 2018

Articles

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells (482 Online Views)

Beibei Zhang, Pilar Ayuda Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink, Bjørn Tore Gjertsen Group, Emmet McCormack Group

https://doi.org/10.3324/haematol.2018.189399