Haematologica. Open access journal of the Ferrata-Storti Foundation, a no profit organization
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
Haematologica. Open access journal of the Ferrata-Storti Foundation, a no profit organization
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
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Open access journal of the Ferrata-Storti Foundation, a non-profit organization
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7th European Myeloma Network Meeting, Prague, 16-18 April 2026
Vol. 111 No. s2
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P10 | HIGH ACCURACY OF NEXT-GENERATION FLOW IN PREDICTING MEASURABLE RESIDUAL DISEASE BY NEXT-GENERATION SEQUENCING IN THE 10⁻⁶ RANGE: A PROSPECTIVE COMPARISON WITHIN THE PHASE III EMN24 ISKIA TRIAL (214 Online Views)

M. D'Agostino1, M. Van Duin2, W. Roeloffzen3, M.A. Dimopoulos4|5, L. Rosiñol6, M. Van Der Klift7, J. Martínez-López8, A. Oriol9, E. Katodritou10, K.L. Wu11, P. Rodríguez Otero12, R. Hájek13|14, E. Dama15, D. Oddolo15, G. Gazzera15, E.M. Van Leeuwen-Segarceanu16|17, N.W.C.J. Van De Donk18, S. De Jonge-Peeters19, T.S. Slørdahl20, J. Straub21, M. Westerman22, F. Schjesvold23|24, J. Bladé6, H. Einsele25, M. Boccadoro15, P. Sonneveld2|26, A. Broijl2, F. Gay1

1 Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, Italy
2 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
3 Department of Hematology, University Medical Center Groningen, The Netherlands
4 Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Greece
5 Department of Medicine, Korea University, Seoul, Korea
6 Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clínic de Barcelona, IDIBAPS and PETHEMA/GEM, Spain
7 Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands
8 Hematology Department, Hospital Universitario de Octubre, Medicine Department Complutense University, imas12, CNIO, Madrid, Spain
9 Institut Català d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona, Spain
10 Department of Hematology, Theagenion Cancer Hospital, Thessaloniki, Greece
11 ZNA Cadix, Antwerp, Belgium
12 Cancer Center Clínica Universidad de Navarra, Pamplona, Spain
13 Department of Haematooncology, University Hospital Ostrava, Czech Republic
14 Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic
15 European Myeloma Network, Italy
16 Department of Hematology, St. Antonius Hospital
17 Nieuwegein, The Netherlands
18 Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Hematology, Cancer Center Amsterdam, The Netherlands
19 Department of Hematology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
20 Department of Hematology, St. Olavs University Hospital, Trondheim, Norway
21 Internal Medicine, Hematology Clinic, General University Hospital, Prague, Czech Republic
22 Northwest Clinics, Alkmaar, The Netherlands
23 Oslo Myeloma Center, Department of Hematology, Oslo University Hospital, Sweden
24 KG Jebsen Center for B cell malignancies, University of Oslo, Sweden
25 Department of Internal Medicine II, University Hospital Würzburg, Germany
26 European Myeloma Network, The Netherlands
Multiple Myeloma Measurable residual disease IsaKRd trial

P14 | DARATUMUMAB-BORTEZOMIB-MELPHALAN-PREDNISONE VS. DARATUMUMAB-LENALIDOMIDE-DEXAMETHASONE IN TRANSPLANT-INELIGIBLE REAL-LIFE PATIENTS WITH MULTIPLE MYELOMA: A SUBANALYSIS OF THE PHASE IV REAL MM TRIAL (203 Online Views)

L. Cani1, S. Bringhen2|3, A. Piciocchi4, N. Giuliani5|6, S. Mangiacavalli7, A.P. Falcone8, G. Benevolo1, M. Capriata9, F. Vassallo2, F. Ciceri10, F. Pane11, R. Floris12, M. Cantonetti13, S. Pezzatti14, M. D'Agostino1, A. Casson1, A. Evangelista15, E. Saraci16, M. Mirabile17, B. Gamberi18, A. Conconi19, G. Pietrantuono20, P. Galieni21, P. Curci22, G. Margiotta-Casaluci23, A. Liso24|25, M. Scaldaferri26, B. Bruno1, M. Boccadoro27, A. Larocca1

1 Division of Hematology, AOU Città della Salute e della Scienza di Torino, University of Torino and Department of Molecular Biotechnology and Health Sciences, Italy
2 S. C. Ematologia, Azienda Ospedaliera Santa Croce e Carle, Cuneo, Italy
3 SSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Department of Oncology, AOU Città della Salute e della Scienza di Torino, University of Turin, Italy
4 GIMEMA Foundation, Rome, Italy
5 Department of Medicine and Surgery, University of Parma
6 Hematology, Department of Hemato-Oncology, AOU Parma, Italy
7 Division of Hematology, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy
8 Hematology, IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy
9 Haematology, Department of Translational and Precision Medicine, Azienda Ospedaliera Policlinico Umberto I, Sapienza University of Rome, Italy
10 U. O. Ematologia e Trapianto di Midollo, IRCCS Ospedale San Raffaele, Milan, Italy
11 Hematology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Italy
12 S. C. Ematologia e CTMO, Ospedale Oncologico “A. Businco”, Cagliari, Italy
13 Hematology Unit of Lymphoproliferative Disorders, Policlinico Tor Vergata
14 Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
15 Unit of Clinical Epidemiology, AOU Città della Salute e della Scienza di Torino and CPO Piemonte, Italy
16 University of Torino and Department of Molecular Biotechnology and Health Sciences, Italy
17 Hematology Unit, Ospedale di Civitanova Marche, ASUR AV3 Italy
18 Azienda USL - IRCCS di Reggio Emilia, Italy
19 Division of Hematology, Department of Medicine, Ospedale degli Infermi, Biella, Italy
20 Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy
21 UOC Ematologia e Terapia cellulare, Ospedale C. e G. Mazzoni, Ascoli Piceno, Italy
22 Hematology and Stem Cell Transplantation Unit, AOU Consorziale Policlinico, Bari, Italy
23 Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale/AOU Maggiore della Carità di Novara, Italy
24 Department of Medicine and Surgery, University of Perugia, Italy
25 Hematology/Oncology Unit, Terni Hospital, Italy
26 SC Farmacia Ospedaliera, AOU Città della Salute e della Scienza di Torino, Italy
27 European Myeloma Network, Italy
REAL MM Trial Measurable Residual Disease Multiple Myeloma
Title matches

P11 | PERIPHERAL MEASURABLE RESIDUAL DISEASE ACTIVITY ASSESSMENT BY MALDI-TOF MASS SPECTROMETRY IN PATIENTS WITH NEWLY-DIAGNOSED MULTIPLE MYELOMA IN THE PHASE 3 GMMG-HD7 TRIAL (217 Online Views)

J.X. Jin1, V.R. Ginde2, S. Huhn1|3, P.. Reichert1|3, U. Bertsch1|3, R. Fenk4, B. Besemer5, A. Boquoi6, R. Schroers7, I. Von Metzler8, M. Hänel9, C.. Mann10, L.B. Leypoldt11, B. Heilmeier12, C. Scheid13, T. Peters-Regehr14, I.W. Blau15, C. Müller-Tidow1, S. Luntz16, T.A.W. Holderried17, K. Trautmann-Grill18, D. Gezer19, M. Klaiber-Hakimi20, M. Müller21, E. Shumilov22, W. Knauf23, C.S. Michel24, T. Geer25, H. Riesenberg26, C.. Lutz27, M.S. Raab1, N. Weinhold1, M. Hoffmann28, A. Benner2, P. Findeisen29, K.C. Weisel11, H.J. Salwender30, H. Goldschmidt1|3, E.K. Mai1

1 Heidelberg Myeloma Center, Internal Medicine V, Hematology, Oncology and Rheumatology, and German-speaking Myeloma Multicenter Group GMMG, Heidelberg University Hospital and Medical Faculty Heidelberg, Germany
2 Division of Biostatistics, German Cancer Research Center
3 National Center for Tumor Diseases Heidelberg, Germany
4 Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Germany
5 Department of Internal Medicine II, University Hospital Tübingen, Germany
6 Department for Hematology and Stem Cell Transplantation, University Hospital Essen, Germany
7 Department of Hematology and Oncology, Knappschaft Kliniken, Ruhr-University Bochum, Germany
8 Department of Medicine II-Hematology and Oncology, Goethe-University Frankfurt, University Hospital, Frankfurt am Main, Germany
9 Department of Internal Medicine III, Klinikum Chemnitz, Germany
10 Department for Hematology, Oncology and Immunology, University Hospital Giessen and Marburg, Marburg, Germany
11 Department of Oncology, Hematology and BMT, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
12 Clinic for Oncology and Hematology, Hospital Barmherzige Brueder Regensburg, Germany
13 Department of Internal Medicine I, University Hospital Cologne, Germany
14 The Binding Site GmbH, part of Thermo Fisher Scientific, Schwetzingen, Germany
15 Medical Clinic, Charité University Medicine Berlin, Germany
16 Coordination Centre for Clinical Trials-KKS, University Hospital and Medical Faculty Heidelberg, Germany
17 Department of Hematology, Oncology, Stem Cell Transplantation, Immune and Cell Therapy, Clinical Immunology and Rheumatology, University Hospital Bonn, Germany
18 Department of Internal Medicine I, University Hospital Dresden, Germany
19 Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Germany
20 Clinic for Hematology, Oncology and Palliative Care, Marien Hospital Düsseldorf, Germany
21 Clinic for Hematology, Oncology and Immunology, Klinikum Siloah Hannover, Germany
22 Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Germany
23 Center for Hematology and Oncology Bethanien, Frankfurt am Main, Germany
24 Department of Internal Medicine III, University Hospital Mainz, Germany
25 Department of Internal Medicine III, Diakoneo Clinic Schwäbisch-Hall, Schwäbisch-Hall, Germany
26 Hematology/Oncology Center, Bielefeld, Germany
27 Hematology/Oncology Center, Koblenz, Germany
28 Medical Clinic A, Clinic Ludwigshafen, Germany
29 MVZ Labor Dr. Limbach und Kollegen, Heidelberg, Germany
30 Asklepios Tumorzentrum Hamburg, AK Altona and AK St Georg, Germany. °For The German-Speaking Myeloma Multicenter Group. *Contributed equally as senior authors. *Hd7 Investigators
MALDI-TOF Minimal Residual Disease Multiple Myeloma

P74 | AUTOMATED PANEL-AGNOSTIC FLOW CYTOMETRIC MINIMAL RESIDUAL DISEASE DETECTION IN MULTIPLE MYELOMA USING QUALITY CONTROL-AWARE MACHINE LEARNING (175 Online Views)

E. Akar1, M. Baysal1, S. Cakmak1, S. Akpinar1, B. Turgut1

1 Hematology Department, Tekirdag Namik Kemal University Hospital, Turkey
Multiple Myeloma Minimal residual disease Quality Control

P23 | DARA-VTD AND ASCT+ LENALIDOMIDE LED TO HIGH COMPLETE REIMISSION AND MINIMAL RESIDUAL DISEASE NEGATIVITY RATES BY NGF: A REAL-WORLD STUDY OF THE TUSCAN MYELOMA NETWORK IN 228 PATIENTS (181 Online Views)

V. Venanzi1, S. Ciofini1, E. Antonioli2, G. Buda3, E. Bestoso1, D. Raspadori1, V. Candi4, L. Pengue2, M.L. Del Giudice3, A. Caremani4, S. Moretti5, G. Fontanelli5, I. Attucci2, M. T. Pirrotta5, C. Biagiotti5, S. Birtolo5, S. Grammatico5, S. Pilerci6, L. Notarfranchi7, G. Tancredi3, S. Galimberti3, M. Bocchia1, A. Gozzetti1

1 Department of Medicine Surgery and Neuroscience, Hematology, University of Siena, Italy
2 Department of Hematology, Careggi Hospital and University of Florence, Italy
3 Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Italy
4 Hematology Unit,Ospedale S. Donato, Arezzo, Italy
5 USL Toscana Centro, SOC Oncoematologia, Italy
6 Hematology Ospedale della Versilia, Lucca, Italy
7 Hematology Massa Carrara, Italy
CASSIOPEIA Trial Multiple Myeloma Tuscan network DARA-VTD

P12 | SUBCUTANEOUS DARATUMUMAB (DARA) + BORTEZOMIB/LENALIDOMIDE/DEXAMETHASONE WITH DARA + LENALIDOMIDE MAINTENANCE IN TRANSPLANT-ELIGIBLE PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: ANALYSIS OF SUSTAINED MINIMAL RESIDUAL DISEASE NEGATIVE (189 Online Views)

P. Sonneveld1, P.. Moreau2, H. Einsele3, H. Quach4, P.J. Ho5, M. Beksac6, C. Hulin7, E. Antonioli8, X. Leleu9, S. Mangiacavalli10, A. Perrot11, M. Cavo12, A. Belotti13, A. Broijl1, H. Pei14, A. Sitthi-Amorn14, R.L. Carson14, P. Rodríguez-Otero15, M.A. Dimopoulos16, M. Boccadoro17

1 Erasmus MC Cancer Institute, Rotterdam, The Netherlands
2 University Hospital Hôtel-Dieu, Nantes, France
3 Universitätsklinikum Würzburg, Germany
4 University of Melbourne, Australia
5 Royal Prince Alfred Hospital, Sydney, Australia
6 Ankara University, Turkey
7 Hôpital Haut Lévêque, Pessac, France
8 University of Florence, Italy
9 CHU Poitiers, France
10 University of Pavia, Italy
11 Centre Hospitalier Universitaire de Toulouse, France
12 Bologna University, Italy
13 ASST Spedali Civili di Brescia, Italy
14 Johnson & Johnson, USA
15 Cancer Center Clínica Universidad de Navarra, Pamplona, Spain
16 National and Kapodistrian University of Athens, Greece
17 University of Turin, Italy
Minimal residual disease NDMM Therapy

P77 | LIGHT CHAIN DEPOSITION DISEASE: A RARE CAUSE OF RENAL INJURY WITH EMERGING THERAPEUTIC OPTIONS (150 Online Views)

R. Cassano Cassano1|2, S. Galimberti3, A.G. Bonadio4, L.M.A. Melillo5, D. Giannese6, G. Buda3

1 University of Foggia, Italy
2 University of Washington, Fred Hutchinson Cancer Center, Seattle, USA
3 Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Italy
4 Department of Surgical, Medical, Molecular Pathology and Critical Area, Division of Surgical Pathology II, University of Pisa, Italy
5 Hematology, Riuniti Hospital, Foggia, Italy
6 Department of Clinical and Experimental Medicine, Nephrology Unit, University of Pisa, Italy
Light chain deposition disease Renal Impairment Multiple Myeloma

B05 | SPATIAL IMAGING UNLOCKS THE POTENTIAL OF CHARTING MULTIPLE MYELOMA AND EXTRAMEDULLARY DISEASE (205 Online Views)

V. Desantis1, A. Andriano1, G. De Martino1, T. Düking2, O. Hartwig2, G. Ingravallo3, M. Biondo3, C. Botta4, R. Ria5, A. Vacca5, A.G. Solimando5

1 Department of Precision and Regenerative Medicine and Ionian Area-DiMePRe-J, Section of Pharmacology, University of Bari Aldo Moro, Italy
2 Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany
3 Department of General Surgery and Medical-Surgical Specialties, University of Catania, Italy
4 Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy
5 Internal Medicine "Guido Baccelli", University of Bari Aldo Moro, Italy
Spatial Imaging Plasma Cell Subclones Multiple Myeloma.

P70 | NOVEL MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE CARE PATHWAY FOR THE EARLY DETECTION OF M-PROTEIN RELATED DISEASES (162 Online Views)

M. Minnema1, F. Verheij1, J. Kortleve2, K. Aarsman1, R. Blommers2, R. Oostvogels1, P. Westerweel2

1 Department of Hematology, UMC Utrecht, The Netherlands
2 Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands
MGUS Al Amyloidosis Multiple Myeloma

P18 | MONOCLONAL AND POLYCLONAL CIRCULATING PLASMA CELLS ARE ASSOCIATED WITH DISEASE DISSEMINATION IN MULTIPLE MYELOMA (219 Online Views)

I. Vigliotta1, A. Varacalli1, M. Talarico1|2, V. Solli2, B. Taurisano2, S. Armuzzi2, I. Pistis1, V.M. Vuong2, A. Vitale1, G. Mazzocchetti3|4, E. Borsi1, A. Croce2, M. Martello1, A. Poletti2, C. Nanni5, K. Mancuso1|2, M. Puppi1|2, M. Cavo2, E. Zamagni1|2, C. Terragna1

1 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy
2 Department of Medical and Surgical Sciences - University of Bologna, Italy
3 FABIT-Department of Pharmacy and Biotechnology, University of Bologna, Italy
4 Computational and Chemical Biology, Italian Institute of Technology, CMP3VdA, Aosta, Italy
5 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Nuclear Medicine, Bologna, Italy
Circulating Plasma Cells Multiple Myeloma NDMM

P07 | CYTOKINE AND BONE MICROENVIRONMENT PROFILES REFLECT DISEASE STAGE AND OSTEOLYTIC INVOLVEMENT IN MULTIPLE MYELOMA (203 Online Views)

J. Minarik1, J. Proskova2, V. Latal1, P. Krhovska1, T. Pika1

1 Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic
2 Department of Clinical Biochemistry Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic
Multiple Myeloma Osteolytic Involvement

P40 | EFFICACY AND SAFETY OF TALQUETAMAB + TECLISTAMAB IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA AND EXTRAMEDULLARY DISEASE: UPDATED PHASE 2 RESULTS FROM THE RedirecTT-1 STUDY WITH EXTENDED FOLLOW-UP (195 Online Views)

M.V. Mateos1, P. Rodríguez-Otero2, S.Z. Usmani3, S. Kumar4, J.C. Ye5, S. Atrash6, H. Magen7, H. Quach8, M.P. Chu9, S. Trudel10, J. Richter11, H. Chuah12, M. Gatt13, E. Medvedova14, S. Raza15, D.H. Yoon16, T. Ishida17, J.V. Matous18, L. Rosiñol19, K. Onodera20, C. Maffucci21, E. Scott21, C. Heuck21, J. Zhang21, T. Henninger21, L. O’Rourke21, P. Thakkar21, M. Festa21, L. Huang21, J. Zhou21, M. Takamoto21, L. Pei21, J. Lu21, N. Au21, M. Krevvata21, Y.C. Cohen7

1 University Hospital of Salamanca, Spain
2 Cancer Center Clínica Universidad de Navarra, Pamplona, Spain
3 Memorial Sloan Kettering Cancer Center, New York, USA
4 Mayo Clinic Rochester, USA
5 University of Texas, Houston, USA
6 Levine Cancer Institute-Atrium Health, Charlotte, USA
7 Tel Aviv University, Israel
8 University of Melbourne, Australia
9 Alberta Health Services, Edmonton, Canada
10 Princess Margaret Cancer Centre, Toronto, Canada
11 Mount Sinai Medical Center, New York, USA
12 Royal Perth Hospital, Australia
13 Hebrew University of Jerusalem, Israel
14 Oregon Health and Science University, Portland, USA
15 Cleveland Clinic, USA
16 University of Ulsan College of Medicine, Seoul, Korea
17 Japanese Red Cross Medical Center, Tokyo, Japan
18 Colorado Blood Cancer Institute, Denver, USA
19 Hospital Clínic de Barcelona, Spain
20 Tohoku University Hospital, Sendai, Japan
21 Johnson & Johnson
Multiple Myeloma RedirecTT-1 trial RRMM
Text matches

P64 | ODISSEY: A MULTICENTER, OBSERVATIONAL STUDY OF MULTIPLE MYELOMA ITALIAN PATIENTS WHO DISCONTINUED THERAPY IN CLINICAL PRACTICE (171 Online Views)

First match: Introduction. Nowadays continuous treatment until disease progression or unacceptable toxicity remains the main approach in multiple myeloma (MM). However, prolonged e ...

N. Sgherza1, E. Antonioli2, E. Zamagni3|4, C. Conticello5, F. Fazio6, S. Palmieri7, A. Cagnetta8, G. Palumbo9, A.G. Solimando10, R. Della Pepa11, C. Germano12, G. Palazzo13, C. De Risi14, A. Quinto15, G. Buda16, M. Gentile17|18, O. Annibali19, D. De Novellis20, P. Curci1, O. Battisti1, L. Pavan21|22, M. Capriata6, G. Di Carlo13, G. Proietti6, V. Del Fabro23, A.P. Falcone24, R. Spadano25, D. Derudas26, G. Mele27, G. Barilà28, M.T. Petrucci6, F. Di Raimondo5|29, F. Albano1|30, P. Musto1|30

1 Hematology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy
2 Hematology Unit, Careggi University Hospital, Firenze, Italy
3 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli", Italy
4 Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Italy
5 Division of Hematology and Stem Cell Transplantation, Policlinico“G. Rodolico-San Marco”, Catania, Italy
6 Department of Translational and Precision Medicine Hematology, Sapienza University, Roma, Italy
7 Hematology Unit, Ospedale Cardarelli, Napoli, Italy
8 Hematology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy
9 Hematology Unit, AOU Policlinico Riuniti di Foggia, Italy
10 G. Baccelli Unit of Internal Medicine, Department of Precision and Regenerative Medicine and Ionian Area-(DiMePRe-J), School of Medicine, University of Bari Aldo Moro, Italy
11 Department of Clinical Medicine and Surgery, University Federico II, Napoli,Italy
12 Hematology Unit,“Mons. Dimiccoli” Hospital, Barletta, Italy
13 Hematology Unit, “G. Moscati” Hospital, Taranto, Italy
14 Haematology and Transplant Unit, “V. Fazzi” Hospital, Lecce, Italy
15 Hematology and Cell Therapy Unit, IRCCS “G. Paolo II”, Bari, Italy
16 Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Italy
17 Hematology Unit, Department of Onco-Hematology, AO of Cosenza, Italy
18 Department of Pharmacy, Health and Nutritional Science, University of Calabria, Italy
19 Hematology, Stem Cell Transplantation, Fondazione Policlinico Universitario Campus Biomedico di Roma, Italy
20 Hematology and Transplant Center, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy
21 Department of Medicine
22 (DIMED), Hematology section, Padua University School of Medicine, Italy
23 Faculty of Medicine and Surgery “Kore”, University of Enna, Italy
24 Department of Hematology and Bone Marrow Transplant, IRCSS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Italy
25 Hematology Unit, Santo Spirito Hospital, Pescara, Italy
26 Department of Hematology, Businco Hospital, Cagliari, Italy
27 Hematology Unit,“A. Perrino” Hospital, Brindisi, Italy
28 Hematology Unit, Ospedale San Bortolo, Vicenza, Italy
29 Department of General Surgery and Medical-Surgical Specialties, Hematology Section, University of Catania, Italy
30 Department of Precision and Regenerative Medicine and Ionian Area, “Aldo Moro” University School of Medicine, Bari, Italy
Multiple Myeloma ODISSEY study Clinical Features

P63 | TECLISTAMY (EMN40): A PHASE 2 TRIAL OF TECLISTAMAB IN PATIENTS WITH PREVIOUSLY TREATED LIGHT-CHAIN AL AMYLOIDOSIS (197 Online Views)

First match: ... pse. There is no currently approved tx regimen for pts with relapsed/refractory disease. Tec, a B-cell maturation antigen (BCMA) × CD3 bispecific antibody, has demonst ...

M. Roussel1, E. Kastritis2, S.O. Schönland3, K.M. Kortüm4, B. Arnulf5|6, A. Jaccard1, S. Vara7, M. Doyle7, J.M. Schecter7, A. Carpinteiro8, F. Kwok9, G. Palladini10|11, M.C. Minnema12, M. Boccadoro13, P. Sonneveld14|15

1 Hematology, Centre Hospitalier Universitaire Dupuytren, Limoges, France
2 Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Greece
3 Department of Internal Medicine V, Heidelberg University Hospital, Germany
4 Department of Internal Medicine II, University Hospital of Würzburg, Germany
5 Immuno-Hematology, Saint Louis Hospital, AP-HP, Paris, France
6 Université Paris Cité, France
7 Johnson & Johnson
8 Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Germany
9 Department of Haematology, Westmead Hospital, Sydney, Australia
10 Department of Molecular Medicine, University of Pavia, Italy
11 Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
12 Department of Hematology, University Medical Center Utrecht, The Netherlands
13 European Myeloma Network, Italy
14 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
15 European Myeloma Network, The Netherlands
AL amyloidosis TeclistAMY (EMN40) trial

P58 | TRIAL IN PROGRESS: QUINTESSENTIAL-2 – A PHASE 3 STUDY OF ARLOCABTAGENE AUTOLEUCEL VS. STANDARD OF CARE IN ADULT PATIENTS WITH RELAPSED AND REFRACTORY MULTIPLE MYELOMA EXPOSED TO LENALIDOMIDE (195 Online Views)

First match: ... oriness has become increasingly common and poses an additional challenge as the disease is less likely to respond to subsequent treatment. G protein-coupled receptor c ...

E. Lebel1, A. Abdulgawad2, S. Bramanti3, G. Garate4, P.J. Ho5, M. Keränen6, Y. Cohen7, M. Vase8, A. Khot9, I. Kristensen10, R. Leblanc11, C. Lee12, W. Legiec13, H. Magen14, M.V. Mateos15, D. Oh16, L. Pour17, N. Schutz18, A. Spyridonidis19, K. Weisel20, J. Zaucha21, S. Larson22, A. Varshavsky-Yanovsky23, K. Grazioli24, D. Basudhar24, H. Hu24, Y. Meng24, L. Eldjerou24, S. Bal25, S. Harrison9, R. Popat26, M. Raab27, P. Rodriguez-Otero28

1 Hadassah Medical Center, Jerusalem, Israel
2 Christie NHS Foundation Trust, Manchester, UK
3 IRCCS Istituto Clinico Humanitas, Rozzano, Italy
4 Hospital Aleman, Buenos Aires, Argentina
5 Royal Prince Alfred Hospital and University of Sydney, Camperdown, Australia
6 Helsinki University Hospital, Finland
7 Tel Aviv Sourasky Medical Center and Faculty of Medical and Health Sciences, Tel Aviv University, Israel
8 Aarhus Universitetshospital, Midtjylland, Denmark
9 Peter MacCallum Cancer Centre, Royal Melbourne Hospital and University of Melbourne, Victoria, Australia
10 Odense Universitetshospital, Denmark
11 Hematology-Oncology and Cell Therapy University Institute, Hôpital Maisonneuve-Rosemont Research Center, Université de Montréal, Quebec, Canada
12 Royal Adelaide Hospital, Australia
13 St. John of Dukla Oncology Center of Lublin Land,Poland
14 Department of Hematology, Chaim Sheba Medical Center, Ramat-Gan, Faculty of Medicine, Tel Aviv University, Israel
15 Hospital Universitario de Salamanca, Spain
16 Monash Health and Monash University, Clayton, Victoria, Australia
17 Masaryk University and University Hospital Brno, Czech Republic
18 Hospital Italiano de Buenos Aires, Argentina
19 University Hospital of Patras, Greece
20 University Medical Center Hamburg-Eppendorf, Germany
21 Medical University of Gdańsk and University Clinical Center, Poland
22 UCLA Medical Center, Los Angeles, USA
23 Fox Chase Cancer Center Temple Health, Philadelphia, USA
24 Bristol Myers Squibb, Princeton, USA
25 University of Alabama at Birmingham, USA
26 University College London Hospital, UK
27 Universitaetsklinikum Heidelberg, Germany
28 Clinica Universidad de Navarra, Pamplona, Spain
QUINTESSENTIAL-2 Trial Multiple Myeloma RRMM

P33 | ARLOCABTAGENE AUTOLEUCEL, A GPRC5D-TARGETED CAR T-CELL THERAPY FOR PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA: UPDATED PHASE 1 SAFETY AND EFFICACY RESULTS IN PATIENTS WITH 1–3 PRIOR REGIMENS (303 Online Views)

First match: ... ], t[4;14], and/or t[14;16]), 68% had 1q21 gain/amp, and 32% had extramedullary disease. Pts had a median of 2 prior regimens; 29% received 3 prior regimens. All 31 pt ...

S. Bal1, M. Htut2, J. Berdeja3, L. Anderson4, A. Rossi5, T. Gregory6, L. Costa1, H. Hu7, Z. Guo7, J. Chen7, K. Jordahl7, N. Sarkis7, S. Ziyad7, W.M. Kao7, A. Kaeding7, M. Burgess7, O. Nadeem8

1 University of Alabama at Birmingham, USA
2 City of Hope Comprehensive Cancer Center, Duarte, USA
3 Greco-Hainsworth Tennessee Oncology Center for Research, Nashville, USA
4 Hematologic Malignancies and Cellular Therapy Program, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, USA
5 Icahn School of Medicine at Mount Sinai, New York, USA
6 Colorado Blood Cancer Institute, Sarah Cannon Cancer Network, Denver, USA
7 Bristol Myers Squibb, Princeton, USA
8 Dana-Farber Cancer Institute, Boston, USA
RRMM CAR-T cells BCMA

P46 | CIRCULATING PLASMA CELLS AS A DYNAMIC BIOMARKER IN MULTIPLE MYELOMA PATIENTS RECEIVING CAR-T AND BISPECIFIC ANTIBODY THERAPY (154 Online Views)

First match: ... their efficacy, standardized tools for early response assessment and peripheral residual disease (PRD) monitoring remain limited. Circulating plasma cells (CPCs), inclu ...

I. Vigliotta1, A. Varacalli1, M. Talarico1|2, M. Puppi1|2, S. Armuzzi2, B. Taurisano2, I. Pistis1, V. Solli2, V. M. Vuong2, E. Borsi1, A. Vitale1, G. Mazzocchetti3|4, A. Croce2, M. Martello1, A. Poletti2, M. Cavo2, E. Manzato1|2, E. Zamagni1|2, C. Terragna1

1 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Italy
2 Department of Medical and Surgical Sciences - University of Bologna, Italy
3 FABIT-Department of Pharmacy and Biotechnology, University of Bologna, Italy
4 Computational and Chemical Biology, Italian Institute of Technology, CMP3VdA, Aosta, Italy
RRMM CAR-T Circulating plasma cells

P45 | MODELING DORMANCY IN MULTIPLE MYELOMA: FUNCTIONAL AND TRANSCRIPTOMIC CHARACTERIZATION OF SERUM STARVATION AND CHEMOTHERAPY-INDUCED STATES (181 Online Views)

First match: ... cause of late relapse in multiple myeloma (MM), even after a prolonged minimal residual disease (MRD)-negative remission period. Therefore, robust experimental systems ...

Z.S. Najafabadi1, N. Afrin2, M. Helal2, H. Fischer1, M. John2, E. Stanojkovska1, J. Mersi1, S. Kadel1, J. Waldschmidt1, M. Kortüm1, K. Kretzschmar2, H. Einsele1, A. Riedel2, L. Rasche1|2

1 Internal Medicine II, Universitätsklinikum Würzburg, Germany
2 Mildred Scheel Early Career Centre for Cancer Research Würzburg, The Julius-Maximilians-Universität Würzburg, Germany
Multiple Myeloma Cancer cell dormancy 3D Model

P48 | LONG-TERM PROGRESSION-FREE SURVIVAL BENEFIT WITH CILTACABTAGENE AUTOLEUCEL IN STANDARD-RISK RELAPSED/REFRACTORY MULTIPLE MYELOMA (193 Online Views)

First match: ... tics (n=12), were not included in the as-treated analysis. Twelve-month minimal residual disease (MRD)-negative complete response (CR) was defined per the International ...

D. Dytfeld1, L.J. Costa2, A. Oriol3, S. Manier4|5, P.M. Voorhees6, Y. Lin7, M. Htut8, W. Roeloffzen9, P. J. Ho10|11, U. Shah12|13, M. Zhao14, Q. Li15, A. Balogh15, K. Li15, A. Slaughter15, N. Benachour15, C. Lonardi15, A. Ghosh15, H. Sun15, N. Lendvai15, T. Lengil15, N. Patel16, M. Koneru16, E. Florendo16, O. C. Filho16, V. Mahajan16, P. Rodríguez-Otero17, C. Strouse18, A.K. Stewart19|20, S. Sidana21

1 Poznan University of Medical Sciences, Poznań, Poland
2 University of Alabama at Birmingham, USA
3 Hospital Germans Trias i Pujol, Barcelona, Spain
4 University of Lille, France
5 Centre Hospitalier Universitaire Lille, France
6 Wake Forest University, Charlotte, USA
7 Mayo Clinic, Rochester, USA
8 City of Hope Comprehensive Cancer Center, Duarte, USA
9 University Medical Center Groningen, The Netherlands
10 Royal Prince Alfred Hospital, Sydney, Australia
11 The University of Sydney, Australia
12 Memorial Sloan Kettering Cancer Center, New York, USA
13 Weill Cornell Medical College, New York, USA
14 IQVIA, Shangai, China
15 Johnson & Johnson
16 Legend Biotech USA Inc, Somerset, USA
17 Universidad de Navarra, Pamplona, Spain
18 University of Iowa, Iowa City, USA
19 University Health Network, Toronto, Canada
20 The Princess Margaret Cancer Centre, Toronto, Canada
21 Stanford University, USA
CARTITUDE-4 Multiple Myeloma Progression free

P56 | BASELINE IMMUNE PROFILE PREDICTS RESPONSE TO BISPECIFIC ANTIBODIES IN RELAPSED/REFRACTORY MULTIPLE MYELOMA: A REAL-WORLD MONOCENTRIC EXPLORATORY ANALYSIS (168 Online Views)

First match: ... y, Naples, Italy. Eligible patients had received ≥3 prior therapy lines and had measurable disease according to IMWG criteria. BsAbs included teclistamab, elranatamab, an ...

R. Della Pepa1, A. Leone1, L. Esposito1, G.L. D'Elia1, V. Cerbone2, M. Raia2, G. Scalia2, F. Pane1

1 Division of Hematology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Italy
2 Clinical and Experimental Cytometry Unit, Centre for Advanced Biotechnology Franco Salvatore, CEINGE Biotecnologie Avanzate, Naples, Italy

P24 | APPROACHING CURE IN MULTIPLE MYELOMA: A DUAL-CENTER EXPERIENCE AMONG PATIENTS DIAGNOSED BEFORE 2010 (170 Online Views)

First match: Background. Although multiple myeloma (MM) has been known as an incurable disease for many decades, recent advances have extended the survival of MM patients, resultin ...

G. Cengiz Seval1, H. Aytekin2, T. Otlu1, U. Calıs1, M. Beksac1|2

1 Ankara University Faculty of Medicine Department of Hematology, Turkey
2 Istinye University Ankara Liv Hospital, Turkey
Multiple myeloma NDMM Minimal Residual Disease

P34 | CEVOSTAMAB PLUS POMALIDOMIDE AND DEXAMETHASONE IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA: BIOMARKER ANALYSES FROM CAMMA 1 ARM B (171 Online Views)

First match: ... , 15 and 22) were given. Treatment was continued until unacceptable toxicity or disease progression. Soluble BCMA (sBCMA) was measured in plasma using LC/MS and multip ...

R. Popat1, S. Harrison2, C. H. Riley3, H.S. Mian4, A. Spencer5, N. Lavi6, L. Paris7, T. Jelínek8, M. Szarejko9, S. Grosicki10, K. Kim11, I. Sandhu12, S. Chebon13, T. Tyagi14, P. Sewpaul15, L. Richardson15, K. Trunzer13, A. Mishra14, S. Trudel16

1 University College London Hospitals NHS Foundation Trust, UK
2 Peter MacCallum Cancer Centre, Sir Peter MacCallum Department of Oncology, Melbourne University and The Royal Melbourne Hospital, Australia
3 Rigshospitalet, Copenhagen, Denmark
4 McMaster University, Hamilton, Canada
5 Alfred Health-Monash University, Melbourne, Australia
6 Rambam Health Care Campus, Haifa, Israel
7 ASST Papa Giovanni XXIII, Bergamo, Italy
8 Department of Hematooncology, University Hospital Ostrava and University of Ostrava, Czech Republic
9 Medical University of Gdansk, Poland
10 Medical University of Silesia, Katowice, Poland
11 Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea
12 Cross Cancer Institute, University of Alberta, Edmonton, Canada
13 F. Hoffmann-La Roche Ltd, Basel, Switzerland
14 Genentech, Inc, South San Francisco, USA
15 Roche Products Ltd, Welwyn, UK
16 Princess Margaret Cancer Centre and University of Toronto, Canada
CAMMA 1 study BCMA Multiple Myeloma

B07 | PROGNOSTIC ROLE OF STANDARDIZED (18)F-FDG-PET/CT AND WB-DW-MRI IN RELAPSED/REFRACTORY MULTIPLE MYELOMA PATIENTS RECEIVING T CELL-REDIRECTING THERAPIES (278 Online Views)

First match: ... /refractory multiple myeloma (RRMM), with unprecedented response rates, minimal residual disease (MRD) negativity and outcome. The prognostic role of functional imaging ...

M. Talarico1|2, A. Cattabriga1|3, L. Pagnini1|4, V. Solli1|2, S. Barbato1|2, S. Ghibellini1|2, S. Masci1|2, E. Manzato1|2, M. Puppi1|2, M. Iezza1|2, K. Mancuso1|2, L. Pantani2, P. Tacchetti2, C. Terragna2, M. Ursi5, E. Maffini5, F. Bonifazi5, S. Brocchi3, C. Mosconi1|3, C. Nanni4, S. Fanti1|4, E. Zamagni1|2

1 Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Italy
2 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Italy
3 Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy
4 Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy
5 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy
RRMM Functional Imaging T-cell Therapy

P22 | WHEN TRIAL DESIGN MEETS APPROVED MAINTENANCE: A SINGLE-CENTER REAL-WORLD EXPERIENCE WITH DARA-VTD INDUCTION AND CONSOLIDATION FOLLOWED BY LENALIDOMIDE MAINTENANCE IN TRANSPLANT-ELIGIBLE MULTIPLE MYELOMA (204 Online Views)

First match: ... val (OS) were analyzed. Results. Among 103 patients, 19 (18%) had ISS stage III disease and 15 (15%) had high-risk cytogenetics (IMS-IMWG 2025 definition). Twenty-four ...

A. Belotti1, S. Terlizzi2, S. Martorana2, R. Ribolla1, C. Crippa1, S. Ferrari1, N. Bianchetti1, C. Bottelli1, C. Cattaneo1, M. Chiarini3, V. Giustini3, A. Roccaro4, A. Tucci1

1 Department of Hematology, ASST Spedali Civili di Brescia, Italy
2 University of Brescia, Italy
3 Clinical Chemistry Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Italy
4 Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, Italy
CASSIOPEIA trial Dara-VTd Transplant-eligible

B10 | HEPTA-REFRACTORY MULTIPLE MYELOMA: BIOLOGY, PROGNOSIS, AND TREATMENT (263 Online Views)

First match: ... a (MM) eventually relapse. An increasing number of patients are presenting with disease refractory to CD38-targeting antibodies, two immunomodulatory drugs (IMiDs), tw ...

C. Riedhammer1, M. Truger2, H. Lee3, L.B. Leypoldt4|5, M. Meggendorfer2, S. Hutter2, H. Müller2, J. Mersi1, S.K. Kadel1, T. Buchwald1, R. Kosch4, M. Helal6, N. Afrin6, A. Rosenwald7, E. Gerhard-Hartmann7, A. Brioli8|9, J. Krönke8, T. Haferlach2, C. Haferlach2, K.C. Weisel4, P. Neri3, H. Einsele1, K.M. Kortüm1, J.M. Waldschmidt1, N. Bahlis3, N. Weinhold10|11, L. Rasche1|6

1 Department of Internal Medicine 2, University Hospital of Würzburg, Germany
2 MLL Munich Leukemia Laboratory, Germany
3 Arnie Charbonneau Cancer Institute, University of Calgary, Canada
4 Department of Hematology, Oncology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Germany
5 Mildred Scheel Early Career Center, University Medical Center Hamburg-Eppendorf, Germany
6 Mildred Scheel Early Career Center, University Hospital Würzburg, Germany
7 Institute of Pathology, University of Würzburg, Germany
8 Department of Internal Medicine C, University Hospital of Greifswald, Germany
9 Hannover Medical School, Clinic for Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Germany
10 Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Medical Faculty, Heidelberg University, Germany
11 Clinical Cooperation Unit Molecular Hematology/Oncology, Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg University and German Cancer Research Center, Germany
Multiple myeloma Hepta-refractory Immunotherapy.
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