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Case Reports

Longitudinal single-cell analysis reveals dynamic clonal competition and convergent evolution shaped by therapy sequencing in a young patient with chronic lymphocytic leukemia

Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Institute of Medical Genetics and Genomics, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Institute of Medical Genetics and Genomics, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Institute of Medical Genetics and Genomics, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Institute of Medical Genetics and Genomics, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Institute of Medical Genetics and Genomics, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic
Department of Internal Medicine – Hematology and Oncology, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Institute of Medical Genetics and Genomics, University Hospital Brno and Medical Faculty, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic
Haematologica Early view Aug 27, 2026 https://doi.org/10.3324/haematol.2026.301080

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Early view : Case Reports
 
DOI
https://doi.org/10.3324/haematol.2026.301080
 
Published
2026-08-27
Published By
Ferrata Storti Foundation, Pavia, Italy
Print ISSN
0390-6078
Online ISSN
1592-8721
 
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Copyright (c) 2026 Ferrata Storti Foundation
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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ISSN 0390-6078 print | ISSN 1592-8721 online