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Case Reports

Clonal expansion of CAR-T cells harboring lentivector integration in the PLAAT4 gene following anti-CD19 CAR T-cell therapy in a context of cutaneous T-cell lymphoma

Sorbonne University, INSERM, Institut Pierre Louis d’Epidémiologie et de Sante Publique (IPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, Virology department, Paris
Sorbonne University, Paris, France, Department of Biological Hematology, Pitié- Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris
Sorbonne Université, INSERM U1135, Center for Immunology and Infectious Diseases (CIMI), Department of Immunology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris
Sorbonne University, INSERM UMRS-938, Saint-Antoine Research Center, TGF-ß, signalisation cellulaire et cancer, Department of Endocrine and Oncological Biochemistry, Unit of Cellular and Molecular Oncobiology, AP-HP, Pitié-Salpêtrière Hospital, Assistance Publique – Hôpitaux de Paris, Paris
Sorbonne University, INSERM UMRS-938, Saint-Antoine Research Center, TGF-ß, signalisation cellulaire et cancer, Department of Endocrine and Oncological Biochemistry, Unit of Cellular and Molecular Oncobiology, AP-HP, Pitié-Salpêtrière Hospital, Assistance Publique – Hôpitaux de Paris, Paris
Sorbonne University, Department of Pathological Anatomy and Cytology, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière Charles Foix, Paris
Sorbonne University, Paris, France, Department of Biological Hematology, Pitié- Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris
Sorbonne Université, INSERM U1135, Center for Immunology and Infectious Diseases (CIMI), Department of Immunology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris
Sorbonne Université, INSERM U1135, Center for Immunology and Infectious Diseases (CIMI), Department of Immunology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris
Department of Hematology, University Hospital of Rennes, UMR U1236, INSERM, University of Rennes, French Blood Establishment, Rennes
Sorbonne University, Department of Clinical Hematology and Cellular Therapy, Hôpital Saint-Antoine, Assistance Publique—Hôpitaux de Paris, INSERM, UMRs 938, Centre de recherche Saint-Antoine (CRSA), Paris, France; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston
Sorbonne University, INSERM, Institut Pierre Louis d’Epidémiologie et de Sante Publique (IPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, Virology department, Paris
Sorbonne University, INSERM, Institut Pierre Louis d’Epidémiologie et de Sante Publique (IPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, Virology department, Paris
Sorbonne University, Unit of Dermatology, Pitié-Salpêtrière Hospital, Assistance Publique – Hôpitaux de Paris, Paris
Sorbonne University, INSERM, Institut Pierre Louis d’Epidémiologie et de Sante Publique (IPLESP), Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, Virology department, Paris
Sorbonne University, Department of Clinical Hematology, Pitié-Salpêtrière Hospital, Assistance Publique – Hôpitaux de Paris, Paris
Haematologica Early view Jun 11, 2026 https://doi.org/10.3324/haematol.2026.300851

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Early view : Case Reports
 
DOI
https://doi.org/10.3324/haematol.2026.300851
 
Published
2026-06-11
Published By
Ferrata Storti Foundation, Pavia, Italy
Print ISSN
0390-6078
Online ISSN
1592-8721
 
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ISSN 0390-6078 print | ISSN 1592-8721 online