Letters to the Editor

Germline EZH2 mutation cooperates with somatic KIT D816V to drive early pediatric advanced systemic mastocytosis

French reference center on mastocytosis and mast related disorders (CEREMAST), Imagine Institute, INSERM U1163, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris
French reference center on mastocytosis and mast related disorders (CEREMAST), Imagine Institute, INSERM U1163, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris
French reference center on mastocytosis and mast related disorders (CEREMAST), Imagine Institute, INSERM U1163, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris, France; Department of Hematology, Necker-Cochin Children’s Hospital, AP-HP, Paris Centre University, Paris
INSERM UMR 1287, Gustave Roussy Cancer Center, Paris-Saclay University, Villejuif
Department of Pathology, Necker Children’s Hospital, AP-HP, Paris Centre University, Paris
Department of Pathology, Necker Children’s Hospital, AP-HP, Paris Centre University, Paris
French reference center on mastocytosis and mast related disorders (CEREMAST), Imagine Institute, INSERM U1163, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris
Department of Pediatric Dermatology, Pellegrin Children’s Hospital Group, Bordeaux University Hospital (CHU de Bordeaux), Bordeaux
Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, Heidelberg
Department of Pediatric Hematology–Oncology, Pellegrin Children’s Hospital Group, Bordeaux University Hospital (CHU de Bordeaux), Bordeaux
INSERM UMR 1287, Gustave Roussy Cancer Center, Paris-Saclay University, Villejuif
French reference center on mastocytosis and mast related disorders (CEREMAST), Imagine Institute, INSERM U1163, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris, France; Department of Hematology, Necker-Cochin Children’s Hospital, AP-HP, Paris Centre University, Paris
French reference center on mastocytosis and mast related disorders (CEREMAST), Imagine Institute, INSERM U1163, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris, France; Department of Dermatology, Reference Center for Rare Skin Disorders in Children, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris
French reference center on mastocytosis and mast related disorders (CEREMAST), Imagine Institute, INSERM U1163, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris, France; Department of Dermatology, Reference Center for Rare Skin Disorders in Children, AP-HP, Necker Children’s Hospital, Paris Centre University, Paris
Haematologica Early view Jul 30, 2026 https://doi.org/10.3324/haematol.2025.300049