CURRENT ISSUE
January, 2026
No. 111 (1)

Landmark papers in Hematology

1

Editorials

6

Review Series

7
Celebrating the Centenary of Von Willebrand Disease

Guidelines

1

Reporting blast percentage for response assessment in acute leukemias: recommendations from an EHA/ELN expert panel (2419 Online Views)

Sa A. Wang, Leonor Arenillas, Francesco Buccisano, Monika Bruggemann, Wolfgang Kern, Manuel Menes, Adriana Plesa, Louisa Stone, Dominique Wellnitz, David A. Westerman, Brent L. Wood, Sylvie D. Freeman

https://doi.org/10.3324/haematol.2025.288228

Erratum

1

Articles

18
Acute Lymphoblastic Leukemia

PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia (1670 Online Views)

Vesna S. Stanulović, Sarah Binhassan, Budoor A. Jaber, Shimaa Alazmi, Fatma M.B. Saleman, Sandeep Potluri, Guy Pratt, Christian Ludwig, Douglas G. Ward, Maarten Hoogenkamp

https://doi.org/10.3324/haematol.2024.287124

Impact of minimal residual disease on the outcome of hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia within the FORUM trial (1901 Online Views)

Adriana Balduzzi, Evgenia Glogova, Christina Peters, Petr Sedlacek, Jean-Hugues Dalle, Franco Locatelli, Roland Meisel, Birgit Burkhardt, Jochen Buechner, Jacek Wachowiak, Marc Bierings, Raquel Staciuk, Stelios Graphakos, Tayfun Güngör, Akif Yesilipek, Peter Svec, Julia Palma, Gergely Krivan, Cristina Diaz-de-Heredia, Francesca Limido, Marc Ansari, Krzysztof Kalwak, Peter Bader, Marianne Ifversen

https://doi.org/10.3324/haematol.2025.287456

Acute Myeloid Leukemia

The small GTPase ARF6 regulates sphingolipid homeostasis and supports proliferation in acute myeloid leukemia (1714 Online Views)

Helong Gary Zhao, Nataly Cruz-Rodriguez, Kent C. Johnson, Anthony D. Pomicter, Briana Bates, Benjamin Bateman, Torsten Haferlach, Tongjun Gu, Jonathan Ahmann, Dongqing Yan, Greg S. Lee, Weiquan Zhu, Jenna Bishop, Shannon J. Odelberg, Michael W. Deininger

https://doi.org/10.3324/haematol.2024.286228

Guadecitabine improved relapse-free survival in high-risk acute myeloid leukemia and myelodysplastic syndrome patients after transplant: phase II results from a single center (1632 Online Views)

Betül Oran, Peter Thall, Amin Alousi, Gheath Al-Atrash, Rohtesh Mehta, David Marin, Partow Kebriaei, Uday Popat, Roland Bassett, Qaiser Bashir, Jin Im, Amanda Olson, Jessica Jewell, Portia Smallbone, Elizabeth Shpall, Richard Champlin

https://doi.org/10.3324/haematol.2025.287628

Longer time from diagnosis to initiation of hypomethylating agents plus venetoclax for acute myeloid leukemia does not worsen survival: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND) (2180 Online Views)

Samuel J. Yates, Julian J. Weiss, Abigail Sneider, Emily Geramita, Guru Subramanian Guru Murthy, Talha Badar, Annie Im, Chenyu Lin, Wei Cheng, Yasmin Abaza, Alok Swaroop, Eric S. Winer, Mark R. Litzow, Ehab L. Atallah, Anand Ashwin Patel, Rory M. Shallis

https://doi.org/10.3324/haematol.2025.288085

Bone Marrow Failure

Hematopoietic stem cell transplantation is effective in achieving long-term survival for post-aplastic anemia myeloid neoplasms: the EBMT Severe Aplastic Anemia Report (2319 Online Views)

Pedro Henrique Prata, Dirk-Jan Eikema, Brian Piepenbroek, Austin Kulasekararaj, Beatrice Drexler, Jennifer M-L. Tjon, Krista Vaht, Mahmoud Aljurf, Patrice Chevallier, Tobias Gedde-Dahl, Ain Kaare, Urpu Salmenniemi, Thomas Schroeder, Jenny Byrne, Jérôme Cornillon, Fiorenza Barraco, Johan Maertens, Eleni Tholouli, Uwe Platzbecker, Nicolaus Kröger, Didier Blaise, Simona Sica, Robert Zeiser, Antonio Maria Risitano, Régis Peffault de Latour; EBMT Severe Aplastic Anemia Working Party (Collaborative Group)

https://doi.org/10.3324/haematol.2024.287205

Cell Therapy & Immunotherapy

Intensified conditioning with high-dose total marrow irradiation and myeloablative chemotherapy reduces risk of relapse without increasing toxicity in allogeneic hematopoietic stem cell transplant for high-risk myeloid malignancies: a phase II study (1831 Online Views)

Lucas Maahs, Ana Maria Avila, Matthew Koshy, Karen Sweiss, Kang-hyun Ahn, Zhengjia Chen, Chukwuemeka Uzoka, Carlos Galvez, Matias Sanchez, Paul Rubinstein, John Quigley, Elisa Zucchetti, Nadim Mahmud, Bulent Aydogan, Pritesh Patel, Damiano Rondelli

https://doi.org/10.3324/haematol.2025.287457

Cytopenias and infections following ciltacabtagene autoleucel in heavily pretreated relapsed or refractory multiple myeloma (2135 Online Views)

Danai Dima, Jennifer M. Logue, Syed Hamza Bin Waqar, Lauren C. Peres, Christelle M. Colin-Leitzinger, Gabriel De Avila, Eric C. Smith, Lawrence Skelson, Kristy L. Matte, Brandon Blue, Vanna N. Hovanky, Mahmoud Gaballa, Oren Pasvolsky, Laura B. Oswald, Gliceida Galarza M. Fortuna, Charlotte B. Wagner, Shaun DeJarnette, Christen Dillard, Fabiana Perna, Lekha Mikkilineni, Hitomi Hosoya, Ciara L. Freeman, Kenneth H. Shain, Rachid C. Baz, Ariel Grajales-Cruz, Omar Castaneda Puglianini, Melissa Alsina, Frederick L. Locke, Leyla O. Shune, Douglas W. Sborov, Krina K. Patel, Surbhi Sidana, Doris K. Hansen

https://doi.org/10.3324/haematol.2025.287783

Chronic Lymphocytic Leukemia

CD6 expression is an independent predictor of time to first treatment in chronic lymphocytic leukemia (1567 Online Views)

Laura Carrillo-Serradell, Juan Antonio Piñeyroa, Pablo Bousquets-Muñoz, Violeta Planells-Romeo, Lucía Aragón-Serrano, Sergi Casadó-Llombart, Dolors Colomer, María Velasco-de Andrés, Xose S. Puente, Julio Delgado, Pablo Mozas, Francisco Lozano

https://doi.org/10.3324/haematol.2025.287564

Rethinking the feasibility and safety of venetoclaxobinutuzumab in chronic lymphocytic leukemia: nontraditional factors may play a role in clinical practice (2127 Online Views)

Anna Maria Frustaci, Andrea Galitzia, Mariano Lucignano, Lorena Appio, Jacopo Olivieri, Alessandro Sanna, Claudia Baraté, Fabrizio Pane, Luana Schiattone, Beatrice Casadei, Isacco Ferrarini, Amalia Figuera, Paolo Sportoletti, Giacomo Loseto, Caterina Stelitano, Andrea Visentin, Melania Celli, Francesca Romana Mauro, Massimiliano Palombi, Marta Coscia, Vanessa Innao, Riccardo Moia, Marina Motta, Filomena Russo, Monica Tani, Annalisa Arcari, Elia Boccellato, Chiara Borella, Enrico Capochiani, Angela Ferrari, Massimo Gentile, Roberta Giachetti, Annamaria Giordano, Martina Bullo, Enrico Lista, Luigi Malandruccolo, Maurizio Musso, Marzia Varettoni, Federico Vozella, Francesca Cibien, Michele Merli, Laura Nocilli, Maria Cristina Pasquini, Azzurra Anna Romeo, Valentina Rossi, Gloria Turri, Anna Vanazzi, Marina Cavaliere, Alessandro Gozzetti, Lara Crucitti, Moira Lucesole, Marina Deodato, Annamaria Tomasso, Arianna Zappaterra, Roberta Murru, Caterina Patti, Luca Laurenti, Alessandra Tedeschi

https://doi.org/10.3324/haematol.2025.287799

Coagulation & its Disorders

Mechanisms sensitive to different drugs mediate a proadhesive and pro-thrombotic platelet phenotype in antiphospholipid syndrome (1663 Online Views)

Marina Camera, Marta Brambilla, Paola Adele Lonati, Alessia Becchetti, Claudia Grossi, Kevin Nallio, Arianna Da Via, Laura Trespidi, Maria Orietta Borghi, Francesco Tedesco, Pier Luigi Meroni

https://doi.org/10.3324/haematol.2024.287133

Complications in Hematology

Hematopoiesis

Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop (1868 Online Views)

Ruiqing Chen, Qiongye Dong, Lihong Zhou, Hanqing He, Yingxue Du, Qianwen Sun, Toshio Suda, Tao Cheng, Jianwei Wang

https://doi.org/10.3324/haematol.2025.287765

Non-Hodgkin Lymphoma

Safety and efficacy of the combination of copanlisib and nivolumab in patients with Richter’s transformation or transformed non-Hodgkin lymphoma: results from a phase I trial (1811 Online Views)

Geoffrey Shouse, Canping Chen, Alexandra Muir, Leslie Popplewell, Tanya Siddiqi, Jasmine Zain, Alex F. Herrera, Olga Danilova, Carly Roleder, Lili Wang, Stephen E.F. Spurgeon, Adam S. Kittai, Lu Chen, Zheng Xia, Matthew S. Davids, Alexey V. Danilov

https://doi.org/10.3324/haematol.2024.286945

Plasma Cell Disorders

Macrophages promote aberrant DNA repair in multiple myeloma via the CXCL5/8-CXCR2 axis (1695 Online Views)

Mengmeng Dong, Donghua He, Jinna Zhang, Haimeng Yan, Haoguang Chen, Enfan Zhang, Yili Feng, Jingsong He, Xi Huang, Guoqiao Chen, Xiuna Sun, Fei Cheng, Huiyao Gu, Huanping Wang, Anyong Xie, Zhen Cai; Cai Lab (Collaborative Group)

https://doi.org/10.3324/haematol.2025.287312

The impact of age on survival and excess mortality after autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients (1821 Online Views)

Shohei Mizuno, Luuk Gras, Laurien G.A. Baaij, Linda Koster, Anita D'Souza, Parameswaran N. Hari, Noel Estrada-Merly, Wael Saber, Andrew J. Cowan, Minako Iida, Shinichiro Okamoto, Hiroyuki Takamatsu, Koji Kawamura, Yoshihisa Kodera, Nada Hamad, Bor-Sheng Ko, Christopher Liam, Kim Wah Ho, Ai Sim Goh, Tan Sui Keat, Alaa M. Elhaddad, Ali Bazarbachi, Brig Qamar Un N Chaudhry, Rozan Alfar, Mohamed Amine Bekadja, Malek Benakli, Cristobal Augusto Frutos Ortiz, Eloisa Riva, Estelle Verburgh, Sebastian Galeano, Francisca Bass, Hira Mian, Arleigh McCurdy, Feng Rong Wang, Daniel Neumann, Mickey Boon Chai Koh, John A. Snowden, Stefan Schönland, Donal P. McLornan, Patrick J. Hayden, Anna Maria Sureda Balari, Hildegard T. Greinix, Mahmoud Aljurf, Yoshiko Atsuta, Damiano Rondelli, Dietger W. Niederwieser, Laurent Garderet

https://doi.org/10.3324/haematol.2025.288041

Platelet Biology & its Disorders

Altered platelet lipidome in bleeding patients with unexplained platelet function defects (1971 Online Views)

Bianca de Jonckheere, Dino Mehic, Dominik Kopczynski, Anita Pirabe, Waltraud Schrottmaier, Anna Schmuckenschlager, Cristina Coman, Tim Dreier, Helmuth Haslacher, Alexander Tolios, Cihan Ay, Ingrid Pabinger, Johanna Gebhart, Robert Ahrends, Alice Assinger

https://doi.org/10.3324/haematol.2025.287698

Red Cell Biology & its Disorders

Early detection and management of extracranial arteriopathy reduces the incidence of silent cerebral infarcts in sickle cell anemia: a long-term prospective cohort study (1431 Online Views)

Francoise Bernaudin, Cecile Arnaud, Annie Kamdem, Jenny Youn, Manuela Vasile, Isabelle Hau, Fouad Madhi, Aline Malterre, Celine Delestrain, Ralph Epaud, Camille Jung, Suzanne Verlhac

https://doi.org/10.3324/haematol.2025.287720

Letters to the Editor

17

Post-transplant maintenance with blinatumomab for children, adolescents, and young adults with relapsed and refractory B-cell acute lymphoblastic leukemia: results of phase I in SCT-ALL-BLIN21 (2194 Online Views)

Hirotoshi Sakaguchi, Kimiyoshi Sakaguchi, Itaru Kato, Hisashi Noma, Hidefumi Hiramatsu, Hiroyuki Ishida, Hiromasa Yabe, Hiroaki Goto, Yuta Kawahara, Yuka Iijima Yamashita, Masashi Sanada, Takao Deguchi, Yoshiyuki Takahashi, Akiko M. Saito, Masatoshi Takagi, Keisuke Okuno, Takashi Taga, Keizo Horibe, Yasuhiro Okamoto, Katsuyoshi Koh, Atsushi Manabe, Katsutsugu Umeda; The Transplantation and Cellular Therapy Committee of Japanese Children’s Cancer Group (Collaborative Group)

https://doi.org/10.3324/haematol.2024.286719

Asparaginase-associated pancreatitis during therapy for pediatric acute lymphoblastic leukemia (1608 Online Views)

M. Beth McCarville, Emily Ashcraft, Raul C. Ribeiro, Matthew Rees, Hope D. Swanson, Hiroto Inaba, Sima Jeha, Cheng Cheng, Ching-Hon Pui, Seth E. Karol

https://doi.org/10.3324/haematol.2024.286803

Durable remission achieved in pediatric patients with TCF3-HLF-positive relapsed/refractory B-cell acute lymphoblastic leukemia by dual CD19- and CD22-targeted chimeric antigen receptor T-cell therapy (1743 Online Views)

Xinyu Wan, Tianyi Wang, Jing Yang, Xiaomin Yang, Wenjie Li, Lixia Ding, Liu Yang, Jing Zhang, Meng Su, Kang An, Zicha Zhou, Yue Li, Xiang Wang, Hua Zhu, Chengjuan Luo, Longjun Gu, Jing Chen, Lili Song, Yanjing Tang, Benshang Li

https://doi.org/10.3324/haematol.2024.287023

Two decades of single-institution data reveal rare longterm survivors of relapsed/refractory Burkitt lymphoma (1556 Online Views)

Rabeya Molla, Kurt Bantilan, Ellin Berman, Philip Caron, Lorenzo Falchi, Paul Hamlin, Steven Horwitz, Andrew Intlekofer, Anita Kumar, Jennifer Lue, Alison Moskowitz, Colette Owens, Maria Lia Palomba, Parastoo Bahrami Dahi, Gilles Salles, Santosha Vardhana, Gunjan Shah, Andrew Zelenetz, William Johnson, Ariela Noy

https://doi.org/10.3324/haematol.2024.287165

Metronomic low-dose regimen of decitabine and venetoclax is safe and reduces monocyte burden in chronic myelomonocytic leukemia (1539 Online Views)

Bradley Rockwell, Mendel Goldfinger, Ioannis Mantzaris, Aditi Shastri, Yogen Saunthararajah, Kira Gritsman, Alejandro R. Sica, Noah Kornblum, Nishi Shah, David Levitz, Lauren C. Shapiro, Ridhi Gupta, Anne Munoz, Aradhika Dhawan, Karen Fehn, Monica Comas, Jhannine Verceles, Dennis L. Cooper, Marina Konopleva, Eric J. Feldman, Amit Verma

https://doi.org/10.3324/haematol.2024.287253

Flow cytometric analysis of cerebrospinal fluid identifies patients with occult central nervous system involvement in relapsed pediatric acute lymphoblastic leukemia (1385 Online Views)

Maria Thastrup, Hanne Vibeke Marquart, Mette Levinsen, Aina Ulvmoen, Birgitte Klug Albertsen, Cornelis Jan Pronk, Marianne Olsen, Peder Wehner, Mervi Taskinen, Bodil Als-Nielsen, Kjeld Schmiegelow

https://doi.org/10.3324/haematol.2025.287392

Bortezomib-melphalan-prednisone versus lenalidomide-dexamethasone in elderly patients with multiple myeloma: the Real MM phase IV trial (1763 Online Views)

Sara Bringhen, Lorenzo Cani, Nicola Giuliani, Silvia Mangiacavalli, Giulia Benevolo, Elisabetta Antonioli, Renato Zambello, Roberto Ria, Iolanda Donatella Vincelli, Sonia Ronconi, Sonia More, Antonietta Pia Falcone, Alessandro Allegra, Mattia D'Agostino, Andrea Evangelista, Andrea Capra, Elisa Sciorsci, Paola Curci, Patrizia Tosi, Anna Marina Liberati, Anna Maria Cafro, Angelo Belotti, Francesca Patriarca, Donato Mannina, Katia Mancuso, Francesco Cattel, Giovannino Ciccone, Benedetto Bruno, Mario Boccadoro, Alessandra Larocca

https://doi.org/10.3324/haematol.2025.287510

Metallothionein 1 mediates growth and survival of Dnmt3a;Npm1-mutant acute myeloid leukemia (1492 Online Views)

Patricia A. Colom Díaz, Jayna J. Mistry, Kira A. Young, Chih-Hsing Chou, Nathan Boyer, Ross L. Levine, Nathan Salomonis, H. Leighton Grimes, Jennifer J. Trowbridge

https://doi.org/10.3324/haematol.2025.287662

Efficacy, safety, and health-related quality of life in transplant-ineligible newly diagnosed multiple myeloma patients receiving bortezomib maintenance therapy: a study of the Korean Multiple Myeloma Working Party KMMWP-174 study (1510 Online Views)

Jung Yeon Lee, Seungpil Jung, Suein Choi, Sung-Soo Park, Jin Seok Kim, Je-Jung Lee, Seong Kyu Park, Hyo Jung Kim, Gyeong-Won Lee, Young Hoon Park, Hyeon-Seok Eom, Jeong-A Kim, Min Kyoung Kim, Yundeok Kim, Ho-Jin Shin, Ho Sup Lee, Jihyun Kwon, Chang-Ki Min

https://doi.org/10.3324/haematol.2025.287889

FOXM1 down-regulation is a trigger of isatuximab-induced direct cell death in multiple myeloma cells with 1q+ (2298 Online Views)

Jiro Kikuchi, Naoki Osada, Sae Matsuoka, Tomomi Ohta, Hirotaka Kazama, Heigoro Shirai, Marco Meloni, Marielle Chiron, Hiroshi Yasui, Hideki Nakasone, Yusuke Furukawa

https://doi.org/10.3324/haematol.2025.287904

Pregnancy and childbirth in women with thalassemia: past and present (1368 Online Views)

Anna Demurtas, Barbara Gianesin, Antonietta Zappu, Elena Cassinerio, Simona Leoni, Paolo Ricchi, Carmina Fatigati, Giovan Battista Ruffo, Francesca Miciotto, Domenico Roberti, Immacolata Tartaglione, Anna Maria Pasanisi, Filomena Longo, Francesco Sorrentino, Alessandra Salvo, Lucia De Franceschi, Roberto Lisi, Mauro Murgia, Valentina Pisano, Paola Maria Grazia Sanna, Epifania Rita Testa, Isabella Atzeni, Raffaella Mariani, Caterina Giovanna Valentini, Francesco Arcioni, Luca Barcella, Martina Culcasi, Angelantonio Vitucci, Eleonora Miulli, Pellegrina Pugliese, Ilaria Fotzi, Cristina Paci, Susanna Barella, Antonia Gigante, Gian Luca Forni, Raffaella Origa

https://doi.org/10.3324/haematol.2025.287908

Perioperative management of total hip arthroplasty in hemophilia A following gene therapy (1496 Online Views)

Yanyan Shao, Chuanlong Wu, Wei Liu, Yu Liu, Qiulan Ding, Wenman Wu, Xuefeng Wang, Lei Zhang, Chuan He, Jing Dai

https://doi.org/10.3324/haematol.2025.288074

Characteristics of patients with newly diagnosed acute myeloid leukemia not receiving treatment (1376 Online Views)

Oudai Alkabbani, Yazan Jabban, Rong He, David Viswanatha, Kurt Bessonen, Patricia Greipp, Dragan Jevremovic, James M. Foran, Talha Badar, Cecilia Arana Yi, Yael Kusne, Antoine N. Saliba, Mehrdad Hefazi, Aasiya Matin, William J. Hogan, Abhishek Mangaonkar, Hassan Alkhateeb, Mrinal Patnaik, Mithun Shah, Kebede Begna, Mark R. Litzow, Aref Al-Kali

https://doi.org/10.3324/haematol.2025.288105

Proteomic shifts post-plasma cell therapy in AL amyloid plaques and potential implications for light chaindirected anti-fibril monoclonal antibodies (1326 Online Views)

Matthew J. Rees, Surendra Dasari, Ellen D. McPhail, Angela Dispenzieri, Cristine M. Charlesworth, Eli Muchtar, Morie Gertz, Navin Gupta, Emilie Anderson, Samantha N. Quang, Christopher Dick, Shaji Kumar, Taxiarchis Kourelis

https://doi.org/10.3324/haematol.2025.288217

Case Reports

4

Extensive non-clonal CAR T-cell expansion causing fatal hyperinflammatory syndrome with immune effector cell-associated hemophagocytic lymphohistiocytosis, cytokine release syndrome, and neurotoxicity syndrome (917 Online Views)

Andreas Riedel, Anna M.P. Stanger, Lucca M. Kimmich, Stefan Hug, Adrian E. Fehn, Jan C. Schroeder, Britta Besemer, Nicolas Casadei, German Demidov, Prithivi Jung Thapa, Christoph Faul, Luca Hensen, Claudia Lengerke, Wolfgang Bethge

https://doi.org/10.3324/haematol.2025.288162

ALK-positive histiocytosis and a clonally related chronic myelomonocytic leukemia (604 Online Views)

Gerben E. Breimer, Elisa A. Rozeman, Weibel W. Braunius, Laura G.M. Daenen, Lennart A. Kester, Roos J. Leguit, Rutger Mahieu, Nienke Solleveld-Westerink, Louise Straatman, Frans Schutgens

https://doi.org/10.3324/haematol.2025.288275

Peripheral monoclonal plasmacytosis in infective endocarditis: a tangled web (619 Online Views)

Giuseppe Bertuglia, Enrico Amaducci, Davide Stella, Angela Dattolo, Giorgia Andrea Impala, Sabrina Aliberti, Giuseppina Prato, Mauro Giorgi, Benedetto Bruno, Francesca Gay

https://doi.org/10.3324/haematol.2025.288276

Progressive multifocal leukoencephalopathy and BK virus-nephropathy with bispecific antibody therapy in multiple myeloma (521 Online Views)

Ariel Siegel, Sidorela Reci, Leah Grossman, Charles Gleason, John Crary, Lusheng Song, Jin Park, Daniel Verina, Shriya Desai, Katerina Kappes, Isaac Stillman, Joshua LaBaer, Adolfo Aleman, Sundar Jagannath, Samir Parekh

https://doi.org/10.3324/haematol.2025.288521