February, 2014
No. 99 (2)

Editorials

Editorials & Perspectives

Review Articles

Update on treatment of light chain amyloidosis

Shameem Mahmood, Giovanni Palladini, Vaishali Sanchorawala, Ashutosh Wechalekar

https://doi.org/10.3324/haematol.2013.087619

B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies

José P. Vaqué, Nerea Martínez, Ana Batlle-López, Cristina Pérez, Santiago Montes-Moreno, Margarita Sánchez-Beato, Miguel A. Piris

https://doi.org/10.3324/haematol.2013.096248

Articles

Granulocyte colony-stimulating factor produces long-term changes in gene and microRNA expression profiles in CD34+ cells from healthy donors

Alicia Báez, Beatriz Martín-Antonio, José I. Piruat, Concepción Prats, Isabel Álvarez-Laderas, M. Victoria Barbado, Magdalena Carmona, Álvaro Urbano-Ispizua, Jose Antonio Pérez-Simón

https://doi.org/10.3324/haematol.2013.086959

Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

Tommaso Rondelli, Antonio M. Risitano, Régis Peffault de Latour, Michela Sica, Benedetta Peruzzi, Patrizia Ricci, Wilma Barcellini, Anna Paola Iori, Carla Boschetti, Veronica Valle, Veronique Frémeaux-Bacchi, Maria De Angioletti, Gerard Socie, Lucio Luzzatto, Rosario Notaro

https://doi.org/10.3324/haematol.2013.090001

Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice

Sara Santos Franco, Luigia De Falco, Saghi Ghaffari, Carlo Brugnara, David A. Sinclair, Alessandro Matte’, Achille Iolascon, Narla Mohandas, Mariarita Bertoldi, Xiuli An, Angela Siciliano, Pauline Rimmelé, Maria Domenica Cappellini, Shaday Michan, Elisa Zoratti, Janin Anne, Lucia De Franceschi

https://doi.org/10.3324/haematol.2013.090076

Comparison of placebo and best available therapy for the treatment of myelofibrosis in the phase 3 COMFORT studies

Ruben A. Mesa, Jean-Jacques Kiladjian, Srdan Verstovsek, Haifa Kathrin Al-Ali, Jason Gotlib, Heinz Gisslinger, Richard Levy, Andres Siulnik, Vikas Gupta, Mahmudul Khan, John F. DiPersio, Mari McQuitty, John V. Catalano, Deborah S. Hunter, Laurent Knoops, Michael Deininger, Francisco Cervantes, Carole Miller, Alessandro M. Vannucchi, Richard T. Silver, Tiziano Barbui, Moshe Talpaz, Giovanni Barosi, Elliott F. Winton, Estella Mendeson, Jimmie H. Harvey, Murat O. Arcasoy, Elizabeth Hexner, Roger M. Lyons, Ronald Paquette, Azra Raza, William Sun, Victor Sandor, Hagop M. Kantarjian, Claire Harrison

https://doi.org/10.3324/haematol.2013.087650

Normal karyotype is a poor prognostic factor in myeloid leukemia of Down syndrome: a retrospective, international study

Marjolein Blink, Martin Zimmermann, Christine von Neuhoff, Dirk Reinhardt, Valerie de Haas, Henrik Hasle, Maureen M. O’Brien, Batia Stark, Julie Tandonnet, Andrea Pession, Katerina Tousovska, Daniel K.L. Cheuk, Kazuko Kudo, Takashi Taga, Jeffrey E. Rubnitz, Iren Haltrich, Walentyna Balwierz, Rob Pieters, Erik Forestier, Bertil Johansson, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan

https://doi.org/10.3324/haematol.2013.089425

Intensive induction is effective in selected octogenarian acute myeloid leukemia patients: prognostic significance of karyotype and selected molecular markers used in the European LeukemiaNet classification

Meir Wetzler, Krzysztof Mrózek, Jessica Kohlschmidt, Hervé Dombret, Hartmut Döhner, Sylvain Pilorge, Utz Krug, Andrew J. Carroll, Richard A. Larson, Guido Marcucci, Wolfgang Hiddemann, Thomas Büchner, Clara D. Bloomfield

https://doi.org/10.3324/haematol.2013.092072

Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia

Rocio Sanchez, Janick St-Cyr, Marie-Eve Lalonde, Jasmine Healy, Chantal Richer, Vincent Gagné, Caroline Laverdière, Lewis B. Silverman, Stephen E. Sallan, Donna Neuberg, Jeffery L. Kutok, Ekaterini A. Kritikou, Maja Krajinovic, Daniel Sinnett

https://doi.org/10.3324/haematol.2013.085340

Unrelated umbilical cord blood transplant for adult acute lymphoblastic leukemia in first and second complete remission: a comparison with allografts from adult unrelated donors

David I. Marks, Kwang Ahn Woo, Xiaobo Zhong, Frederick R. Appelbaum, Veronika Bachanova, Juliet N. Barker, Claudio G. Brunstein, John Gibson, Partow Kebriaei, Hillard M. Lazarus, Richard Olsson, Miguel-Angel Perales, Joseph Pidala, Bipin Savani, Vanderson Rocha, Mary Eapen

https://doi.org/10.3324/haematol.2013.094193

Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

Karla Plevova, Hana Skuhrova Francova, Katerina Burckova, Yvona Brychtova, Michael Doubek, Sarka Pavlova, Jitka Malcikova, Jiri Mayer, Boris Tichy, Sarka Pospisilova

https://doi.org/10.3324/haematol.2013.087593

Actual prognosis during follow-up of survivors of B-cell non-Hodgkin lymphoma in the Netherlands

Saskia A.M. van de Schans, Liza N. van Steenbergen, Jan Willem W. Coebergh, Maryska L.G. Janssen-Heijnen, Dick Johan van Spronsen

https://doi.org/10.3324/haematol.2012.081885

Risk factors for Epstein-Barr virus-related post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation

Michael Uhlin, Helena Wikell, Mikael Sundin, Ola Blennow, Markus Maeurer, Olle Ringden, Jacek Winiarski, Per Ljungman, Mats Remberger, Jonas Mattsson

https://doi.org/10.3324/haematol.2013.087338

Soft-tissue extramedullary multiple myeloma prognosis is significantly worse in comparison to bone-related extramedullary relapse

Ludek Pour, Sabina Sevcikova, Henrieta Greslikova, Renata Kupska, Petra Majkova, Lenka Zahradova, Viera Sandecka, Zdenek Adam, Marta Krejci, Petr Kuglik, Roman Hajek

https://doi.org/10.3324/haematol.2013.094409

Development of a coordinated allo T cell and auto B cell response against autosomal PTK2B after allogeneic hematopoietic stem cell transplantation

Anita N. Kremer, Judith C. van der Griendt, Edith D. van der Meijden, M. Willy Honders, Burcu Ayoglu, Jochen M. Schwenk, Peter Nilsson, J.H. Frederik Falkenburg, Marieke Griffioen

https://doi.org/10.3324/haematol.2013.086652

Alternative donor hematopoietic stem cell transplantation for mature lymphoid malignancies after reduced-intensity conditioning regimen: similar outcomes with umbilical cord blood and unrelated donor peripheral blood

Celso Arrais Rodrigues, Vanderson Rocha, Peter Dreger, Claudio Brunstein, Henrik Sengeloev, Jürgen Finke, Mohamad Mohty, Bernard Rio, Eefke Petersen, François Guilhot, Dietger Niederwieser, Jan J. Cornelissen, Pavel Jindra, Arnon Nagler, Nathalie Fegueux, Hélène Schoemans, Stephen Robinson, Annalisa Ruggeri, Eliane Gluckman, Carmen Canals, Anna Sureda

https://doi.org/10.3324/haematol.2013.088997

Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

José Luis Piñana, Jaime Sanz, Alessandra Picardi, Christelle Ferrá, Rodrigo Martino, Pere Barba, Marta Gonzalez-Vicent, María Jesús Pascual, Carmen Martín, Amparo Verdeguer, Cristina Diaz de Heredia, Pau Montesinos, José-María Ribera, Miguel Sanz, William Arcese, Guillermo Sanz

https://doi.org/10.3324/haematol.2013.091009

Response endpoints and failure-free survival after initial treatment for acute graft-versus-host disease

Yoshihiro Inamoto, Paul J. Martin, Barry E. Storer, Marco Mielcarek, Rainer F. Storb, Paul A. Carpenter

https://doi.org/10.3324/haematol.2013.093062

Guidelines

European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma

Monika Engelhardt, Evangelos Terpos, Martina Kleber, Francesca Gay, Ralph Wäsch, Gareth Morgan, Michele Cavo, Niels van de Donk, Andreas Beilhack, Benedetto Bruno, Hans Erik Johnsen, Roman Hajek, Christoph Driessen, Heinz Ludwig, Meral Beksac, Mario Boccadoro, Christian Straka, Sara Brighen, Martin Gramatzki, Alessandra Larocca, Henk Lokhorst, Valeria Magarotto, Fortunato Morabito, Meletios A. Dimopoulos, Hermann Einsele, Pieter Sonneveld, Antonio Palumbo

https://doi.org/10.3324/haematol.2013.099358

Errata Corrige

European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia

Diana Averbuch, Christina Orasch, Catherine Cordonnier, David M. Livermore, Malgorzata Mikulska, Claudio Viscoli, Inge C. Gyssens, Winfried V. Kern, Galina Klyasova, Oscar Marchetti, Dan Engelhard, Murat Akova

https://doi.org/10.3324/haematol.2014.103770

Letters to the Editor

High XBP1 expression is a marker of better outcome in multiple myeloma patients treated with bortezomib

Manuela Gambella, Alberto Rocci, Roberto Passera, Francesca Gay, Paola Omedè, Claudia Crippa, Paolo Corradini, Alessandra Romano, Davide Rossi, Marco Ladetto, Mario Boccadoro, Antonio Palumbo

https://doi.org/10.3324/haematol.2013.090142

Efficacy and safety of sildenafil for the treatment of severe pulmonary hypertension in patients with hemoglobinopathies: results from a long-term follow up

Giorgio Derchi, Manuela Balocco, Patrizio Bina, Vincenzo Caruso, Domenico G D’Ascola, Roberto Littera, Raffaella Origa, Maria D. Cappellini, Gian L. Forni

https://doi.org/10.3324/haematol.2013.095810

Rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases

Annette Fasan, Claudia Haferlach, Alexander Kohlmann, Frank Dicker, Christiane Eder, Wolfgang Kern, Torsten Haferlach, Susanne Schnittger

https://doi.org/10.3324/haematol.2013.099754

Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group

Thomas Burmeister, Gesine Bartels, Daniela Gröger, Heiko Trautmann, Stefan Schwartz, Klaus Lenz, Carola Tietze-Bürger, Andreas Viardot, Ralph Wäsch, Heinz-August Horst, Richard Reinhardt, Nicola Gökbuget, Dieter Hoelzer, Michael Kneba, Monika Brüggemann

https://doi.org/10.3324/haematol.2013.090720

Obituary