Review Articles



Rare inherited coagulation disorders and thrombosis (480 Online Views)

Massimo Franchini, Samin Mohsenian, Pier Mannuccio Mannucci




Reframing leukemia-niche interactions: the emerging role of the marrow adipocyte lineage (399 Online Views)

Bexultan Kazybay, Mauricio N. Ferrao Blanco, Olaf Heidenreich, Hermann Josef Vormoor


Immune checkpoint therapy in pediatric and adolescent lymphomas (1424 Online Views)

David J. Hoogstra, Ana C. Xavier, Paul Harker-Murray, Sarah Alexander, Lisa Giulino-Roth, Teresa A. Hernandez, Mitchell S. Cairo


Prognosis in marginal zone lymphoma: a comprehensive review (1437 Online Views)

Annalisa Talami, Maria Elena Nizzoli, Emilia Cappello, Stefano Luminari, Luca Arcaini




NEAT1: a multifaceted long non-coding RNA in multiple myeloma (2198 Online Views)

Gabriele Benini, Sara Taranto, Margherita Sciumè, Fabio Rigali, Raffaella Marcheselli, Andrea Abate, Stefania Mitola, Sandra Sigala, Antonio Sacco, Aldo M. Roccaro


JAK inhibitor selection in challenging scenarios of myelofibrosis: a review (7492 Online Views)

Pankit Vachhani, Ruben Mesa, John Mascarenhas, Raajit Rampal, Stephen T. Oh, Alessandro Maria Vannucchi, Maria Laura Fox, Francesca Palandri, Francesco Passamonti, Jean-Jacques Kiladjian, Mahshid Azimi, Claire Harrison, Prithviraj Bose




CHIP ahoy: charting a decade of discovery in clonal hematopoiesis (4537 Online Views)

Casey K. Wong, Alexandra McDonald, Marco M. Buttigieg, Michael J. Rauh




Treatment-related mutagenic processes in acute lymphoblastic leukemia (3618 Online Views)

Cédric G. van der Ham, Frank N. van Leeuwen, Roland P. Kuiper



Asparaginase-associated hyperammonemia (6666 Online Views)

Raheel Altaf Raja, Bodil Als-Nielsen, Allan M. Lund, Hendrik Vilstrup, Kim Peder Dalhoff, Kjeld Schmiegelow


Global estimation of the bleeding episodes treatable with desmopressin in von Willebrand disease and hemophilia A (5234 Online Views)

Alessandro Gringeri, Pier Mannuccio Mannucci, Michele Gringeri, Giancarlo Castaman, Flora Peyvandi







Clinical and laboratory risk factors for sickle cell retinopathy and maculopathy: a scoping review of the current evidence (3975 Online Views)

Rajani P. Brandsen, Roselie M.H. Diederen, Gizem Kocabas, Erfan Nur, Arjan Malekzadeh, Reinier O. Schlingemann, Bart J. Biemond


Infections in sickle cell disease (33209 Online Views)

Lily E.A. Scourfield, Amina Nardo-Marino, Thomas N. Williams, David C. Rees


Resistance to immunomodulatory drugs in multiple myeloma: the cereblon pathway and beyond (8843 Online Views)

Phaik Ju Teoh, Mun Yee Koh, Constantine Mitsiades, Sarah Gooding, Wee Joo Chng







Germline variants in acquired aplastic anemia: current knowledge and future perspectives (10734 Online Views)

Peicheng Wang, Wanzhi Jiang, Tianyi Lai, Qi Liu, Yingying Shen, Baodong Ye, Dijiong Wu


Epigenetic regulation of megakaryopoiesis and platelet formation (8113 Online Views)

Baichuan Xu, Xianpeng Ye, Zhaoyang Wen, Shilei Chen, Junping Wang




Health-related quality of life in patients with hematologic malignancies treated with chimeric antigen receptor T-cell therapy: review and current progress (5495 Online Views)

Emmanuelle Tchernonog, Aline Moignet, Amélie Anota, Sophie Bernard, Guy Bouguet, Fanny Colin, Catherine Rioufol, Loïc Ysebaert, Emmanuel Gyan


CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis (8081 Online Views)

Gael Vermeersch, Paul Proost, Sofie Struyf, Mieke Gouwy, Timothy Devos




Emicizumab: the hemophilia A game-changer (22772 Online Views)

Pedro E. Alcedo Andrade, Pier Mannuccio Mannucci, Craig M. Kessler


How we manage a high D-dimer (255113 Online Views)

Massimo Franchini, Daniele Focosi, Mario Piergiulio Pezzo, Pier Mannuccio Mannucci



Clinical perspectives on the optimal use of lenalidomide plus bortezomib and dexamethasone for the treatment of newly diagnosed multiple myeloma (8154 Online Views)

Paul G. Richardson, Brian G. Durie, Laura Rosiñol, Maria-Victoria Mateos, Angela Dispenzieri, Philippe Moreau, Shaji Kumar, Noopur Raje, Nikhil Munshi, Jacob P. Laubach, Peter O’Gorman, Elizabeth O’Donnell, Peter Voorhees, Thierry Facon, Joan Bladé, Sagar Lonial, Aurore Perrot, Kenneth C. Anderson



Down syndrome and leukemia: from basic mechanisms to clinical advances (14515 Online Views)

André Baruchel, Jean-Pierre Bourquin, John Crispino, Sergi Cuartero, Henrik Hasle, Johann Hitzler, Jan-Henning Klusmann, Shai Izraeli, Andrew A. Lane, Sébastien Malinge, Karen R. Rabin, Irene Roberts, Sandra Ryeom, Sarah K. Tasian, Elvin Wagenblast




Shwachman-Diamond syndromes: clinical, genetic, and biochemical insights from the rare variants (15468 Online Views)

Nozomu Kawashima, Usua Oyarbide, Marco Cipolli, Valentino Bezzerri, Seth J. Corey







How we manage cardiovascular disease in patients with hemophilia (8688 Online Views)

Massimo Franchini, Daniele Focosi, Pier Mannuccio Mannucci



Biosimilars in rare diseases: a focus on paroxysmal nocturnal hemoglobinuria (4655 Online Views)

Austin Kulasekararaj, Robert Brodsky, Alexander Kulagin, Jun Ho Jang


Prevention and management of secondary central nervous system lymphoma (33073 Online Views)

Sabela Bobillo, Jahanzaib Khwaja, Andrés J.M. Ferreri, Kate Cwynarski


Animal models of Diamond-Blackfan anemia: updates and challenges (8048 Online Views)

Y. Lucy Liu, Aya Shibuya, Bert Glader, Mark C. Wilkes, Maria Barna, Kathleen M. Sakamoto




IgM monoclonal gammopathies of clinical significance: diagnosis and management (24137 Online Views)

Jahanzaib Khwaja, Shirley D’Sa, Monique C. Minnema, Marie José Kersten, Ashutosh Wechalekar, Josephine M. Vos






Interactions of adenoviruses with platelets and coagulation and the vaccine-induced immune thrombotic thrombocytopenia syndrome (6697 Online Views)

Paolo Gresele, Stefania Momi, Rossella Marcucci, Francesco Ramundo, Valerio De Stefano, Armando Tripodi




2021 European Myeloma Network review and consensus statement on smoldering multiple myeloma: how to distinguish (and manage) Dr. Jekyll and Mr. Hyde (14793 Online Views)

Pellegrino Musto, Monika Engelhardt, Jo Caers, Niccolo’ Bolli, Martin Kaiser, Niels van de Donk, Evangelos Terpos, Annemiek Broijl, Carlos Fernández de Larrea, Francesca Gay, Hartmut Goldschmidt, Roman Hajek, Annette Juul Vangsted, Elena Zamagni, Sonja Zweegman, Michele Cavo, Meletios Dimopoulos, Hermann Einsele, Heinz Ludwig, Giovanni Barosi, Mario Boccadoro, Maria-Victoria Mateos, Pieter Sonneveld, Jesus San Miguel


Novel immunotherapies in multiple myeloma – chances and challenges (5681 Online Views)

Leo Rasche, Ralph Wäsch, Markus Munder, Hartmut Goldschmidt, Marc S. Raab



Targeting the tumor microenvironment in chronic lymphocytic leukemia (9387 Online Views)

Rebecka Svanberg, Sine Janum, Piers E.M. Patten, Alan G. Ramsay, Carsten U. Niemann



The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance (8357 Online Views)

Yasith Mathangasinghe, Bruno Fauvet, Stephen M. Jane, Pierre Goloubinoff, Nadinath B. Nillegoda



European Myeloma Network perspective on CAR T-Cell therapies for multiple myeloma (11427 Online Views)

Benedetto Bruno, Ralph Wäsch, Monika Engelhardt, Francesca Gay, Luisa Giaccone, Mattia D’Agostino, Luis-Gerardo Rodríguez-Lobato, Sophia Danhof, Nico Gagelmann, Nicolaus Kröger, Rakesh Popat, Niels W.C.J. van de Donk, Evangelos Terpos, Meletios A. Dimopoulos, Pieter Sonneveld, Hermann Einsele, Mario Boccadoro



T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective (9194 Online Views)

Fleur S. Peters, Jonathan C. Strefford, Eric Eldering, Arnon P. Kater


Chronic organ injuries in children with sickle cell disease (5831 Online Views)

Slimane Allali, Melissa Taylor, Joséphine Brice, Mariane de Montalembert



Latest culture techniques: cracking the secrets of bone marrow to mass-produce erythrocytes and platelets ex vivo (11136 Online Views)

Christian A. Di Buduo, Alicia Aguilar, Paolo M. Soprano, Alberto Bocconi, Carolina P. Miguel, Giovanna Mantica, Alessandra Balduini













Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding (7211 Online Views)

Alicia Veninga, Ilaria De Simone, Johan W.M. Heemskerk, Hugo ten Cate, Paola E.J. van der Meijden





Multiple myeloma with central nervous system relapse (26465 Online Views)

Philip A. Egan, Patrick T Elder, W. Ian Deighan, Sheila J.M. O’Connor, H. Denis Alexander


Geriatric assessment in older patients with a hematologic malignancy: a systematic review (9628 Online Views)

Ellen R.M. Scheepers, Ariel M. Vondeling, Noortje Thielen, René van der Griend, Reinhard Stauder, Marije E. Hamaker






Glanzmann thrombasthenia: genetic basis and clinical correlates (37305 Online Views)

Juliana Perez Botero, Kristy Lee, Brian R Branchford, Paul F Bray, Kathleen Freson, Michele P. Lambert, Minjie Luo, Shruthi Mohan, Justyne E. Ross, Wolfgang Bergmeier, Jorge Di Paola


How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies (5268 Online Views)

David Wu, Xi Luo, Simone Feurstein, Chimene Kesserwan, Shruthi Mohan, Daniel E. Pineda-Alvarez, Lucy A. Godley, on behalf of the collaborative group of the American Society of Hematology - Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel


The variable manifestations of disease in pyruvate kinase deficiency and their management (39180 Online Views)

Hanny Al-Samkari, Eduard J. van Beers, Kevin H.M. Kuo, Wilma Barcellini, Paola Bianchi, Andreas Glenthøj, María del Mar Mañú Pereira, Richard van Wijk, Bertil Glader, Rachael F. Grace


An international registry of patients with plasminogen deficiency (HISTORY) (8440 Online Views)

Amy D. Shapiro, Marzia Menegatti, Roberta Palla, Marco Boscarino, Christopher Roberson, Paolo Lanzi, Joel Bowen, Charles Nakar, Isaac A. Janson, Flora Peyvandi


Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management (29769 Online Views)

Pasquale Pignatelli, Evaristo Ettorre, Danilo Menichelli, Arianna Pani, Francesco Violi, Daniele Pastori


Innate immune cells, major protagonists of sickle cell disease pathophysiology (8181 Online Views)

Slimane Allali, Thiago Trovati Maciel, Olivier Hermine, Mariane de Montalembert


Fibrin(ogen) in human disease: both friend and foe (113134 Online Views)

Rui Vilar, Richard J. Fish, Alessandro Casini, Marguerite Neerman-Arbez




MYD88 in the driver’s seat of B-cell lymphomagenesis: from molecular mechanisms to clinical implications (14474 Online Views)

Ruben A.L. de Groen, Anne M.R. Schrader, Marie José Kersten, Steven T. Pals, Joost S.P. Vermaat






Updates on the hematologic tumor microenvironment and its therapeutic targeting (5660 Online Views)

Dorian Forte, Daniela S. Krause, Michael Andreeff, Dominique Bonnet, Simón Méndez-Ferrer









Thrombopoietin receptor agonists: ten years later (59268 Online Views)

Waleed Ghanima, Nichola Cooper, Francesco Rodeghiero, Bertrand Godeau, James B. Bussel



CRISPR to fix bad blood: a new tool in basic and clinical hematology (13127 Online Views)

Elisa González-Romero, Cristina Martínez-Valiente, Cristian García-Ruiz, Rafael P. Vázquez-Manrique, José Cervera, Alejandra Sanjuan-Pla



State-of-the-art review: allogeneic stem cell transplantation for myelofibrosis in 2019 (13845 Online Views)

Donal P. McLornan, Ibrahim Yakoub-Agha, Marie Robin, Yves Chalandon, Claire N. Harrison, Nicolaus Kroger



IgG4-related disease: what a hematologist needs to know (385090 Online Views)

Luke Y.C. Chen, Andre Mattman, Michael A. Seidman, Mollie N. Carruthers


CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies (13547 Online Views)

Lucia Prieto-Torres, Socorro M. Rodriguez-Pinilla, Arantza Onaindia, Mariano Ara, Luis Requena, Miguel Á. Piris






TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics (24969 Online Views)

Elias Campo, Florence Cymbalista, Paolo Ghia, Ulrich Jäger, Sarka Pospisilova, Richard Rosenquist, Anna Schuh, Stephan Stilgenbauer


Preclinical human models and emerging therapeutics for advanced systemic mastocytosis (9044 Online Views)

Michel Arock, Ghaith Wedeh, Gregor Hoermann, Siham Bibi, Cem Akin, Barbara Peter, Karoline V. Gleixner, Karin Hartmann, Joseph H. Butterfield, Dean D. Metcalfe, Peter Valent



Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts (23669 Online Views)

Peter Valent, Guntram Büsche, Igor Theurl, Iris Z. Uras, Ulrich Germing, Reinhard Stauder, Karl Sotlar, Wolfgang Füreder, Peter Bettelheim, Michael Pfeilstöcker, Rainer Oberbauer, Wolfgang R. Sperr, Klaus Geissler, Jürg Schwaller, Richard Moriggl, Marie C. Béné, Ulrich Jäger, Hans-Peter Horny, Olivier Hermine


Cardiovascular adverse events in modern myeloma therapy – Incidence and risks. A review from the European Myeloma Network (EMN) and Italian Society of Arterial Hypertension (SIIA) (8622 Online Views)

Sara Bringhen, Alberto Milan, Claudio Ferri, Ralph Wäsch, Francesca Gay, Alessandra Larocca, Marco Salvini, Evangelos Terpos, Hartmut Goldschmidt, Michele Cavo, Maria Teresa Petrucci, Heinz Ludwig, Holger W. Auner, Jo Caers, Martin Gramatzki, Mario Boccadoro, Hermann Einsele, Pieter Sonneveld, Monika Engelhardt




Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers (5610 Online Views)

Johana Hrdinová, Silvia D’Angelo, Nuno A. G. Graça, Bogac Ercig, Karen Vanhoorelbeke, Agnès Veyradier, Jan Voorberg, Paul Coppo





From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives (10433 Online Views)

Francesca Gay, Monika Engelhardt, Evangelos Terpos, Ralph Wäsch, Luisa Giaccone, Holger W. Auner, Jo Caers, Martin Gramatzki, Niels van de Donk, Stefania Oliva, Elena Zamagni, Laurent Garderet, Christian Straka, Roman Hajek, Heinz Ludwig, Herman Einsele, Meletios Dimopoulos, Mario Boccadoro, Nicolaus Kröger, Michele Cavo, Hartmut Goldschmidt, Benedetto Bruno, Pieter Sonneveld


The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source (9985 Online Views)

Barnaby Peacock-Young, Fraser L. Macrae, Darren J. Newton, Anita Hill, Robert A S Ariëns








Is immunotherapy here to stay in multiple myeloma? (4912 Online Views)

Paula Rodríguez-Otero, Bruno Paiva, Monika Engelhardt, Felipe Prósper, Jesús F. San Miguel


Propagation of thrombosis by neutrophils and extracellular nucleosome networks (5934 Online Views)

Susanne Pfeiler, Konstantin Stark, Steffen Massberg, Bernd Engelmann



Anti-thymocyte globulin as graft-versus-host disease prevention in the setting of allogeneic peripheral blood stem cell transplantation: a review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (6826 Online Views)

Frédéric Baron, Mohamad Mohty, Didier Blaise, Gérard Socié, Myriam Labopin, Jordi Esteve, Fabio Ciceri, Sebastian Giebel, Norbert Claude Gorin, Bipin N Savani, Christoph Schmid, Arnon Nagler



The emerging role of immune checkpoint inhibition in malignant lymphoma (4901 Online Views)

Ida Hude, Stephanie Sasse, Andreas Engert, Paul J. Bröckelmann



The myeloma stem cell concept, revisited: from phenomenology to operational terms (7945 Online Views)

Hans Erik Johnsen, Martin Bøgsted, Alexander Schmitz, Julie Støve Bødker, Tarec Christoffer El-Galaly, Preben Johansen, Peter Valent, Niklas Zojer, Els Van Valckenborgh, Karin Vanderkerken, Mark van Duin, Pieter Sonneveld, Martin Perez-Andres, Alberto Orfao, Karen Dybkær


‘Trained immunity’: consequences for lymphoid malignancies (5069 Online Views)

Wendy B.C. Stevens, Mihai G. Netea, Arnon P. Kater, Walter J.F.M. van der Velden


New insights on hereditary erythrocyte membrane defects (17771 Online Views)

Immacolata Andolfo, Roberta Russo, Antonella Gambale, Achille Iolascon


Osteonecrosis in children with acute lymphoblastic leukemia (8085 Online Views)

Marina Kunstreich, Sebastian Kummer, Hans-Juergen Laws, Arndt Borkhardt, Michaela Kuhlen


Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice (11306 Online Views)

Celalettin Ustun, Michel Arock, Hanneke C. Kluin-Nelemans, Andreas Reiter, Wolfgang R. Sperr, Tracy George, Hans-Peter Horny, Karin Hartmann, Karl Sotlar, Gandhi Damaj, Olivier Hermine, Srdan Verstovsek, Dean D. Metcalfe, Jason Gotlib, Cem Akin, Peter Valent



Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond (4976 Online Views)

Richard Rosenquist, Andreas Rosenwald, Ming-Qing Du, Gianluca Gaidano, Patricia Groenen, Andrew Wotherspoon, Paolo Ghia, Philippe Gaulard, Elias Campo, Kostas Stamatopoulos






Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies (24317 Online Views)

Abdallah Abou Zahr, Mohamed E. Salama, Nicole Carreau, Douglas Tremblay, Srdan Verstovsek, Ruben Mesa, Ronald Hoffman, John Mascarenhas





Role of the tumor microenvironment in mature B-cell lymphoid malignancies (10534 Online Views)

Nathan H. Fowler, Chan Yoon Cheah, Randy D. Gascoyne, John Gribben, Sattva S. Neelapu, Paolo Ghia, Catherine Bollard, Stephen Ansell, Michael Curran, Wyndham H. Wilson, Susan O’Brien, Cliona Grant, Richard Little, Thorsten Zenz, Loretta J. Nastoupil, Kieron Dunleavy


Chronic myeloid leukemia: reminiscences and dreams (18824 Online Views)

Tariq I. Mughal, Jerald P. Radich, Michael W. Deininger, Jane F. Apperley, Timothy P. Hughes, Christine J. Harrison, Carlo Gambacorti-Passerini, Giuseppe Saglio, Jorge Cortes, George Q. Daley






Risk factors for relapse after allogeneic transplantation in acute myeloid leukemia (4776 Online Views)

Gert J. Ossenkoppele, Jeroen J.W.M. Janssen, Arjan A. van de Loosdrecht


Humanized hemato-lymphoid system mice (8890 Online Views)

Alexandre P.A. Theocharides, Anthony Rongvaux, Kristin Fritsch, Richard A. Flavell, Markus G. Manz






Environmental determinants of severity in sickle cell disease (17487 Online Views)

Sanjay Tewari, Valentine Brousse, Frédéric B. Piel, Stephan Menzel, David C. Rees







Epigenetics in the hematologic malignancies (5489 Online Views)

Chun Yew Fong, Jessica Morison, Mark A. Dawson






Survival analysis in hematologic malignancies: recommendations for clinicians (6405 Online Views)

Julio Delgado, Arturo Pereira, Neus Villamor, Armando López-Guillermo, Ciril Rozman


Early lymphoid lesions: conceptual, diagnostic and clinical challenges (11025 Online Views)

Karthik A. Ganapathi, Stefania Pittaluga, Oreofe O. Odejide, Arnold S. Freedman, Elaine S. Jaffe



The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy (6632 Online Views)

Graham Packham, Serge Krysov, Alex Allen, Natalia Savelyeva, Andrew J. Steele, Francesco Forconi, Freda K. Stevenson




Heme and erythropoieis: more than a structural role (23128 Online Views)

Deborah Chiabrando, Sonia Mercurio, Emanuela Tolosano


Nature and importance of follicular lymphoma precursors (5798 Online Views)

Emilie Mamessier, Florence Broussais-Guillaumot, Bruno Chetaille, Reda Bouabdallah, Luc Xerri, Elaine S. Jaffe, Bertrand Nadel


Why methylation is not a marker predictive of response to hypomethylating agents (4786 Online Views)

Maria Teresa Voso, Valeria Santini, Emiliano Fabiani, Luana Fianchi, Marianna Criscuolo, Giulia Falconi, Francesco Guidi, Stefan Hohaus, Giuseppe Leone


Primary thrombocytosis in children (20991 Online Views)

Nicole Kucine, Katherine M. Chastain, Michelle B. Mahler, James B. Bussel



Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy (7005 Online Views)

Siham Bibi, Melis Dilara Arslanhan, Florent Langenfeld, Sylvie Jeanningros, Sabine Cerny-Reiterer, Emir Hadzijusufovic, Luba Tchertanov, Richard Moriggl, Peter Valent, Michel Arock


Management and treatment of osteonecrosis in children and adolescents with acute lymphoblastic leukemia (5825 Online Views)

Mariël L. te Winkel, Rob Pieters, Ernst-Jan D. Wind, J.H.J.M. (Gert) Bessems, Marry M. van den Heuvel-Eibrink


Measurement of adherence to BCR-ABL inhibitor therapy in chronic myeloid leukemia: current situation and future challenges (7316 Online Views)

Lucien Noens, Marja Hensen, Izabela Kucmin-Bemelmans, Christina Lofgren, Isabelle Gilloteau, Bernard Vrijens


Update on treatment of light chain amyloidosis (10065 Online Views)

Shameem Mahmood, Giovanni Palladini, Vaishali Sanchorawala, Ashutosh Wechalekar


B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies (6470 Online Views)

José P. Vaqué, Nerea Martínez, Ana Batlle-López, Cristina Pérez, Santiago Montes-Moreno, Margarita Sánchez-Beato, Miguel A. Piris


Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies (4904 Online Views)

Elias Jabbour, Oliver G. Ottmann, Michael Deininger, Andreas Hochhaus



Advances in myelofibrosis: a clinical case approach (7563 Online Views)

John O. Mascarenhas, Attilio Orazi, Kapil N. Bhalla, Richard E. Champlin, Claire Harrison, Ronald Hoffman


Management recommendations for chronic myelomonocytic leukemia: consensus statements from the SIE, SIES, GITMO groups (5530 Online Views)

Francesco Onida, Giovanni Barosi, Giuseppe Leone, Luca Malcovati, Enrica Morra, Valeria Santini, Giorgina Specchia, Sante Tura


Autophagy in blood cancers: biological role and therapeutic implications (7252 Online Views)

Alessio Nencioni, Michele Cea, Fabrizio Montecucco, Valter D. Longo, Franco Patrone, Angelo M. Carella, Tessa L. Holyoake, G. Vignir Helgason



Classical Hodgkin’s lymphoma: the Lymphoma Study Association guidelines for relapsed and refractory adult patients eligible for transplant (6674 Online Views)

Eric Van Den Neste, Olivier Casasnovas, Marc André, Mohamed Touati, Delphine Senecal, Véronique Edeline, Aspasia Stamatoullas, Luc Fornecker, Bénédicte Deau, Thomas Gastinne, Oumédaly Reman, Isabelle Gaillard, Cécile Borel, Pauline Brice, Christophe Fermé



Indications for hematopoietic stem cell transplantation in patients with follicular lymphoma: a consensus project of the EBMT-Lymphoma Working Party (5123 Online Views)

Silvia Montoto, Paolo Corradini, Martin Dreyling, Michele Ghielmini, Eva Kimby, Armando López-Guillermo, Stephen Mackinnon, Robert E. Marcus, Gilles Salles, Harry C Schouten, Anna Sureda, Peter Dreger


Non-transfusion-dependent thalassemias (17621 Online Views)

Khaled M. Musallam, Stefano Rivella, Elliott Vichinsky, Eliezer A. Rachmilewitz


Iron refractory iron deficiency anemia (14983 Online Views)

Luigia De Falco, Mayka Sanchez, Laura Silvestri, Caroline Kannengiesser, Martina U. Muckenthaler, Achille Iolascon, Laurent Gouya, Clara Camaschella, Carole Beaumont



Clinical implications of the molecular genetics of chronic lymphocytic leukemia (3632 Online Views)

Robin Foà, Ilaria Del Giudice, Anna Guarini, Davide Rossi, Gianluca Gaidano


Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3) (21936 Online Views)

Anna Skiada, Fanny Lanternier, Andreas H. Groll, Livio Pagano, Stephan Zimmerli, Raoul Herbrecht, Olivier Lortholary, George L. Petrikkos





Infections in myelodysplastic syndromes (12163 Online Views)

Andréa Toma, Pierre Fenaux, François Dreyfus, Catherine Cordonnier


Molecular pathogenesis of Waldenström’s macroglobulinemia (5081 Online Views)

Esteban Braggio, Casey Philipsborn, Anne Novak, Lucy Hodge, Stephen Ansell, Rafael Fonseca




Acute myeloid leukemia developing in patients with autoimmune diseases (8942 Online Views)

Safaa M. Ramadan, Tamer M Fouad, Valentina Summa, Syed KH Hasan, Francesco Lo-Coco


Thrombolytic therapy for central venous catheter occlusion (14807 Online Views)

Jacquelyn L. Baskin, Ulrike Reiss, Judith A. Wilimas, Monika L. Metzger, Raul C. Ribeiro, Ching-Hon Pui, Scott C. Howard





An overview of the progress on double umbilical cord blood transplantation (4395 Online Views)

Anastasia Sideri, Nikolaos Neokleous, Philippe Brunet De La Grange, Bernadette Guerton, Marie-Caroline Le Bousse Kerdilles, Georges Uzan, Corina Peste-Tsilimidos, Eliane Gluckman




Chronic lymphocytic leukemia and autoimmunity: a systematic review (18461 Online Views)

Kate Hodgson, Gerardo Ferrer, Emili Montserrat, Carol Moreno


The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues (3582 Online Views)

Richard A. Van Etten, Steffen Koschmieder, Francois Delhommeau, Danilo Perrotti, Tessa Holyoake, Animesh Pardanani, Ruben Mesa, Tony Green, Amr R. Ibrahim, Tariq Mughal, Robert Peter Gale, John Goldman


The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disorders (8466 Online Views)

Anna Merlo, Riccardo Turrini, Riccardo Dolcetti, Debora Martorelli, Elena Muraro, Patrizia Comoli, Antonio Rosato



PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers (9262 Online Views)

Laurent Brault, Christelle Gasser, Franz Bracher, Kilian Huber, Stefan Knapp, Jürg Schwaller


Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia (11813 Online Views)

Sophie Park, Nicolas Chapuis, Jérôme Tamburini, Valérie Bardet, Pascale Cornillet-Lefebvre, Lise Willems, Alexa Green, Patrick Mayeux, Catherine Lacombe, Didier Bouscary



Lymphoma stem cells: enough evidence to support their existence? (4460 Online Views)

Jose A. Martinez-Climent, Lorena Fontan, Randy D. Gascoyne, Reiner Siebert, Felipe Prosper


Anti-CD20 monoclonal antibodies: historical and future perspectives (7604 Online Views)

Sean H. Lim, Stephen A. Beers, Ruth R. French, Peter W.M. Johnson, Martin J. Glennie, Mark S. Cragg


Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies (6558 Online Views)

Sigurdur Y. Kristinsson, Lynn R. Goldin, Magnus Björkholm, Jill Koshiol, Ingemar Turesson, Ola Landgren




Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis (6038 Online Views)

Andrew J. Ramsay, John D. Hooper, Alicia R. Folgueras, Gloria Velasco, Carlos López-Otín


Platelet receptors and signaling in the dynamics of thrombus formation (15817 Online Views)

José Rivera, María Luisa Lozano, Leyre Navarro-Núñez, Vicente Vicente



Mesenchymal stem cells: the fibroblasts’ new clothes? (6796 Online Views)

Muzlifah A. Haniffa, Matthew P. Collin, Christopher D. Buckley, Francesco Dazzi