CURRENT ISSUE
June, 2024
No. 109 (6)

Landmark papers in Hematology

Editorials

Review Series

Immunotherapy for childhood malignancies

Articles

Acute Lymphoblastic Leukemia

CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia (1407 Online Views)

Bruno A. Cardoso, Mafalda Duque, Ana Gírio, Rita Fragoso, Mariana L. Oliveira, James R. Allen, Leila R. Martins, Nádia C. Correia, André Bortolini Silveira, Alexandra Veloso, Shunsuke Kimura, Lisa Demoen, Filip Matthijssens, Sima Jeha, Cheng Cheng, Ching-Hon Pui, Ana R. Grosso, João L. Neto, Sérgio F. de Almeida, Pieter Van Vlieberghe, Charles G. Mullighan, J. Andres Yunes, David M. Langenau, Françoise Pflumio, João T. Barata

https://doi.org/10.3324/haematol.2023.282854

Histone deacetylase inhibition sensitizes p53-deficient B-cell precursor acute lymphoblastic leukemia to chemotherapy (790 Online Views)

Willem P.J. Cox, Nils Evander, Dorette S. van Ingen Schenau, Gawin R. Stoll, Nadia Anderson, Lieke de Groot, Kari J.T. Grünewald, Rico Hagelaar, Miriam Butler, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen

https://doi.org/10.3324/haematol.2023.284101

Acute Myeloid Leukemia

Multi-gene measurable residual disease assessed by digital polymerase chain reaction has clinical and biological utility in acute myeloid leukemia patients receiving venetoclax/azacitidine (1140 Online Views)

Amanda C. Winters, Mohd Minhajuddin, Brett M. Stevens, Ajay Major, Grace Bosma, Diana Abbott, Nicholas Miltgen, Ji Yuan, Amy L. Treece, Bradford J. Siegele, Mark D. Ewalt, Jonathan A. Gutman, Craig T. Jordan, Daniel A. Pollyea

https://doi.org/10.3324/haematol.2023.283790

Genetic landscape and clinical outcomes of patients with BCOR mutated myeloid neoplasms (979 Online Views)

Anmol Baranwal, Mark Gurney, Rami Basmaci, Bahga Katamesh, Rong He, David S. Viswanatha, Patricia Greipp, James Foran, Talha Badar, Hemant Murthy, Cecilia Arana Yi, Jeanne Palmer, Abhishek A. Mangaonkar, Mrinal M. Patnaik, Mark R. Litzow, William J. Hogan, Kebede Begna, Naseema Gangat, Ayalew Tefferi, Aref Al-Kali, Mithun V. Shah, Hassan B. Alkhateeb

https://doi.org/10.3324/haematol.2023.284185

Blood Transfusion

Granulocyte transfusions in severe aplastic anemia (1437 Online Views)

Roma V. Rajput, Vaani Shah, Ruba N. Shalhoub, Kamille West-Mitchell, Nu Ri Cha, Cathy Conry-Cantilena, Susan F. Leitman, David J. Young, Brian Wells, Georg Aue, Cynthia E. Dunbar, Bhavisha A. Patel, Richard W. Childs, Neal S. Young, Colin O. Wu, Emma M. Groarke, Shelley S. Kalsi

https://doi.org/10.3324/haematol.2023.283826

Hematopoiesis

PELI2 regulates early B-cell progenitor differentiation and related leukemia via the IL-7R expression (756 Online Views)

Yan Xu, Qian Zhou, Xiaoming Wang, Aijun Zhang, Wentao Qi, Yuan Li, Chengzu Zheng, Jianmin Guan, Tao Sun, Jingxin Li, Chunhua Lu, Yuemao Shen, Baobing Zhao

https://doi.org/10.3324/haematol.2023.284041

Neoplasms of Lymphoid Tissue

Massive parallel sequencing unveils homologous recombination deficiency in follicular dendritic cell sarcoma (928 Online Views)

Luisa Lorenzi, Torsten Haferlach, Luigi Mori, Matteo Simbeni, Wencke Walter, Piera Balzarini, Manja Meggendorfer, Claudia Döring, Silvia Lonardi, Mattia Bugatti, Claudio Agostinelli, Jay Mehta, Anita Borges, Abbas Agaimy, Ingrid Simonitsch-Klupp, José Cabeçadas, Elias Campo, Stefano Aldo Pileri, Fabio Facchetti, Martin Leo Hansmann, Sylvia Hartmann

https://doi.org/10.3324/haematol.2023.283669

Myeloid Neoplasms

STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia (710 Online Views)

C. Cameron Yin, Wayne Tam, Serena M. Walker, Amandeep Kaur, Madhu M. Ouseph, Wei Xie, Olga K.Weinberg, Peng Li, Zhuang Zuo, Mark J. Routbort, Simon Chen, L. Jeffrey Medeiros, Tracy I George, Attilio Orazi, Daniel A. Arber, Adam Bagg, Robert P. Hasserjian, Sa A. Wang

https://doi.org/10.3324/haematol.2023.284311

Hemostasis

Differences in venous clot structures between hemophilic mice treated with emicizumab versus factor VIII or factor VIIIFc (1009 Online Views)

Thibaud Sefiane, Hortense Maynadié, Carmen Escurola Ettingshausen, Vincent Muczynski, Xavier Heiligenstein, Julien Dumont, Olivier D. Christophe, Cécile V. Denis, Caterina Casari, Peter J. Lenting

https://doi.org/10.3324/haematol.2023.284142

Coagulation & its Disorders

Impact of mild thrombocytopenia on bleeding and recurrent thrombosis in cancer (653 Online Views)

Rushad Patell, Charles Hsu, Minggao Shi, Michael A. Grosso, Anil Duggal, Harry R. Buller, Gary Raskob, Jeffrey I. Zwicker

https://doi.org/10.3324/haematol.2023.284192

Non-Hodgkin Lymphoma

Long-term analysis of the RiBVD phase II trial reveals the unfavorable impact of TP53 mutations and hypoalbuminemia in older adults with mantle cell lymphoma; for the LYSA group (643 Online Views)

Sylvain Carras, Alexia Torroja, Anouk Emadali, Emilie Montaut, Nicolas Daguindau, Adrian Tempescul, Anne Moreau, Emmanuelle Tchernonog, Anna Schmitt, Roch Houot, Caroline Dartigeas, Sarah Barbieux, Selim Corm, Anne Banos, Ludovic Fouillet, Jehan Dupuis, Margaret Macro, Joel Fleury, Fabrice Jardin, Clementine Sarkozy, Ghandi Damaj, Pierre Feugier, Luc Matthieu Fornecker, Cecile Chabrot, Veronique Dorvaux, Krimo Bouabdallah, Sandy Amorim, Reda Garidi, Laurent Voillat, Bertrand Joly, Nadine Morineau, Marie Pierre Moles, Hacene Zerazhi, Jean Fontan, Yazid Arkam, Magda Alexis, Vincent Delwail, Jean Pierre Vilque, Loic Ysebaert, Barbara Burroni, Mary Callanan, Steven Le Gouill, Rémy Gressin

https://doi.org/10.3324/haematol.2023.283724

Chronic Lymphocytic Leukemia

Plasma Cell Disorders

Epigenetic dysregulation of eukaryotic initiation factor 3 subunit E (eIF3E) by lysine methyltransferase REIIBP confers a pro-inflammatory phenotype in t(4;14) myeloma (697 Online Views)

Phyllis S.Y. Chong, Jing Yuan Chooi, Sze Lynn Julia Lim, Tae-Hoon Chung, Reinhard Brunmeir, Aaron Chung Yong Leow, Sabrina Hui Min Toh, Kalpnaa Balan, Muhamad Irfan Bin Azaman, Zhengwei Wu, Nagavidya Subramaniam, Leah A Vardy, Wee-Joo Chng

https://doi.org/10.3324/haematol.2023.283467

Recovery of uninvolved heavy/light chain pair immunoparesis in newly diagnosed transplant-eligible myeloma patients complements the prognostic value of minimal residual disease detection (735 Online Views)

Sunil Lakhwani, Laura Rosiñol, Noemí Puig, Miguel-Angel Pico-Picos, Laura Medina-González, Joaquín Martínez-López, Bruno Paiva, María-Teresa Cedena, Albert Oriol, Rafael Ríos-Tamayo, María-Jesús Blanchard, Isidro Jarque, Joan Bargay, José-María Moraleda, Estrella Carrillo-Cruz, Anna Sureda, Isabel Krsnik, Esther González, Luis Felipe Casado, Josep M Martí, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol, Yolanda González-Montes, Cristina Motlló, Javier De La Cruz, Rafael Alonso, María-Victoria Mateos, Joan Bladé, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández

https://doi.org/10.3324/haematol.2023.284154

Red Cell Biology & its Disorders

Epeleuton, a novel synthetic ω-3 fatty acid, reduces hypoxia/ reperfusion stress in a mouse model of sickle cell disease (704 Online Views)

Alessandro Mattè, Enrica Federti, Antonio Recchiuti, Moayed Hamza, Giulia Ferri, Veronica Riccardi, Jacopo Ceolan, Alice Passarini, Filippo Mazzi, Angela Siciliano, Deepak L Bhatt, David Coughlan, John Climax, Elisa Gremese, Carlo Brugnara, Lucia De Franceschi

https://doi.org/10.3324/haematol.2023.284028

Letters to the Editor

A retrospective analysis of gene fusions and treatment outcomes in pediatric acute megakaryoblastic leukemia without Down syndrome (436 Online Views)

Kyogo Suzuki, Asahito Hama, Yusuke Okuno, Yinyan Xu, Atsushi Narita, Nao Yoshida, Hideki Muramatsu, Nobuhiro Nishio, Koji Kato, Seiji Kojima, Keon Hee Yoo, Yoshiyuki Takahashi

https://doi.org/10.3324/haematol.2023.283760

Hepatosplenic T-cell lymphoma displays an original oyster-shell cytological pattern and a genomic profile distinct from that of γδ T-cell large granular lymphocytic leukemia (676 Online Views)

Anne Desmares, Simon Bouzy, Florian Thonier, Julien Goustille, Francisco Llamas-Gutierrez, Franck Genevieve, Laurane Cottin, Lucile Baseggio, Pierre Lemaire, Carinne Lecoq Lafon, Pascale Cornillet-Lefebvre, Anne-Cécile Galoisy, Chantal Brouzes, Emmanuelle Rault, Elodie Dindinaud, Carole Fleury, Florence Blanc-Jouvan, Soraya Wuilleme, Valérie Bardet, Thierry Fest, Thierry Lamy, Mikael Roussel, Mélanie Pannetier, Cédric Pastoret

https://doi.org/10.3324/haematol.2023.283856

Update and European consensus on a patient-centered core outcome set for multiple myeloma in clinical practice and research (532 Online Views)

Simone Oerlemans, Belle H. de Rooij, Christine Bennink, Lars Bullinger, Annemiek Broijl, Mattia D’Agostino, Edward Laane, Maria Teresa Lupo-Stanghellini, Aurore Perrot, Ruth Wester, Viorica Cursaru, Hans Scheurer, Jan Vesseur, Mehul Dalal, Rohini Sen, Tanja Stamm, Heinz Ludwig, Pieter Sonneveld

https://doi.org/10.3324/haematol.2023.284282

Longitudinal dynamics and clinically available predictors of poor response to COVID-19 vaccination in multiple myeloma (448 Online Views)

Gaurav Agarwal, Sally Moore, Ross Sadler, Sherin Varghese, Alison Turner, Lucia Y Chen, Jemma Larham, Nathanael Gray, Oluremi Carty, Joe Barrett, Constantinos Koshiaris, Jaimal Kothari, Stella Bowcock, Udo Oppermann, Vicky Gamble, Gordon Cook, Chara Kyriakou, Mark Drayson, Supratik Basu, Sarah McDonald, Shelagh McKinley, Sarah Gooding, Muhammad K Javaid, Karthik Ramasamy

https://doi.org/10.3324/haematol.2023.284286

TENT5C/FAM46C modulation in vivo reveals a trade-off between antibody secretion and tumor growth in multiple myeloma (613 Online Views)

Massimo Resnati, Sara Pennacchio, Lisa Viviani, Tommaso Perini, Maria Materozzi, Ugo Orfanelli, Jessica Bordini, Raffaella Molteni, Mario Nuvolone, Matteo Da Vià, Francesca Lazzaroni, Niccolò Bolli, Simone Cenci, Enrico Milan

https://doi.org/10.3324/haematol.2023.284299

Randomized phase III GnG study on two schedules of gemtuzumab ozogamicin as adjunct to intensive induction therapy and double-blinded intensive postremission therapy with or without glasdegib in patients with newly diagnosed acute myeloid leukemia (533 Online Views)

Sonia Jaramillo, Johannes Krisam, Lucian Le Cornet, Markus Kratzmann, Lukas Baumann, Olga Eissymont, Martina Crysandt, Martin Görner, Sabine Kayser, Stefan Krause, Christoph Schliemann, Tobias Gaska, Martin Kaufmann, Jens Chemnitz, Markus Schaich, Alexander Hoellein, Uwe Platzbecker, Meinhard Kieser, Carsten Müller-Tidow, Richard F. Schlenk

https://doi.org/10.3324/haematol.2023.284346

A randomized, double-blind study of zinpentraxin alfa in patients with myelofibrosis who were previously treated with or ineligible for ruxolitinib: stage 2 of a phase II trial (703 Online Views)

Srdan Verstovsek, Moshe Talpaz, Martha Wadleigh, Alessandro Isidori, Peter te Boekhorst, Michael R. Savona, Prithviraj Bose, Olga Pozdnyakova, Ruben Mesa, Tarec C. El-Galaly, Jennifer O’Sullivan, Katia Gamel, Brian Higgins, Sudhakar Katakam, Boyan Todorov, Kerstin Trunzer, Claire N. Harrison

https://doi.org/10.3324/haematol.2023.284410

Targeting CCR4 with mogamulizumab in refractory CD3-CD4+ lymphocytic-variant hypereosinophilic syndrome (548 Online Views)

Emmanuel Ledoult, Matthieu Groh, Bertrand Meresse, Romain Dubois, Jacques Trauet, Elise Toussaint, Marie Delbeke, Eric Hachulla, Louis Terriou, Adèle De Masson, Michele Vasseur, Myriam Labalette, David Launay, Jean-Emmanuel Kahn, Guillaume Lefevre

https://doi.org/10.3324/haematol.2023.284429

Role of red cell mass evaluation in myeloproliferative neoplasms with splanchnic vein thrombosis and normal hemoglobin value: a study of the France Intergroupe des Syndromes myeloprolifératifs (456 Online Views)

Jean Galtier, Louis Drevon, Yannick Le Bris, Stephane Giraudier, Mathieu Wemeau, Laurence Legros, Damien Luque Paz, François Girodon, Jean-Jacques Kiladjian, Charles Mesguich, Marie Parrens, Clémence Mediavilla, Lydia Roy, Alexandre Guy, Olivier Mansier, Jean-Christophe Ianotto, Chloe James

https://doi.org/10.3324/haematol.2023.284488

A phase II randomized, placebo-controlled, multicenter trial to evaluate the efficacy of cytomegalovirus PepVax vaccine in preventing cytomegalovirus reactivation and disease after allogeneic hematopoietic stem cell transplant (581 Online Views)

Ryotaro Nakamura, Corinna La Rosa, Dongyun Yang, Joshua A. Hill, Armin Rashidi, Hannah Choe, Qiao Zhou, Chetan Raj Lingaraju, Teodora Kaltcheva, Jeffrey Longmate, Jennifer Drake, Cynthia Slape, Lupe Duarte, Monzr M. Al Malki, Vinod A. Pullarkat, Ahmed Aribi, Steven Devine, Michael R. Verneris, Jeffrey S. Miller, Stephen J. Forman, Ibrahim Aldoss, Don J. Diamond

https://doi.org/10.3324/haematol.2023.284544

The outcome of allogeneic hematopoietic stem cell transplantation among elderly patients with severe aplastic anemia and a predictive model from the Chinese Blood and Marrow Transplant Registry group (875 Online Views)

Zheng-Li Xu, Lan-Ping Xu, Yi-Cheng Zhang, Yu-Hong Zhou, Er-Lie Jiang, Jian-Ping Zhang, Bin Fu, Gui-Fang Ouyang, Xian-Min Song, Xue-Jun Zhang, Yu-Jun Dong, Nai-Nong Li, Ling Wang, Xi Zhang, Peng-Cheng He, Fan-Sheng Kong, Hui-Xia Liu, Li Liu, Lin Liu, Tai-Wu Xiao, Wen-Wei Xu, Xiao-Jun Xu, Guo-Lin Yuan, Hai Yi, Dan Yu, Li Yu, Xiao-Jun Huang

https://doi.org/10.3324/haematol.2023.284581

Case Reports

Cerebral venous sinus thrombosis and thrombocytopenia due to heparin-independent anti-PF4 antibodies after adenovirus infection (1105 Online Views)

Günalp Uzun, Jan Zlamal, Karina Althaus, Andrea Bevot, Florian Hennersdorf, Nina Wolska, Anna Jock, Jan Kern, Vanya Icheva, Sven Poli, Ulrike Ernemann, Andreas Neu, Tamam Bakchoul

https://doi.org/10.3324/haematol.2023.284127

Treatment of immune-mediated thrombotic thrombocytopenic purpura without plasma exchange (521 Online Views)

Marco Capecchi, Giada Gazzola, Pasquale Agosti, Pasqualina De Leo, Ilaria Mancini, Barbara Ferrari, Juri Alessandro Giannotta, Andrea Artoni, Flora Peyvandi

https://doi.org/10.3324/haematol.2023.284438