January, 2021
No. 106 (1)

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Editorials

Review Articles

Articles

Acute Lymphoblastic Leukemia

Clinical significance of occult central nervous system disease in adult acute lymphoblastic leukemia. A multicenter report from the Campus ALL Network (2800 Online Views)

Maria Ilaria Del Principe, Elisa Buzzatti, Alfonso Piciocchi, Fabio Forghieri, Massimiliano Bonifacio, Federica Lessi, Silvia Imbergamo, Enrico Orciuolo, Giovanni Rossi, Nicola Fracchiolla, Silvia Trappolini, Benedetta Neri, Chiara Sarlo, Patrizia Zappasodi, Michelina Dargenio, Mariagiovanna Cefalo, Maria Antonietta Irno-Consalvo, Consuelo Conti, Giovangiacinto Paterno, Gottardo De Angelis, Mariarita Sciumè, Irene Della Starza, Adriano Venditti, Robin Foà, Anna Rita Guarini

https://doi.org/10.3324/haematol.2019.231704

Outcomes after late bone marrow and very early central nervous system relapse of childhood B-acute lymphoblastic leukemia: a report from the Children's Oncology Group phase III study AALL0433 (5241 Online Views)

Glen Lew, Yichen Chen, Xiaomin Lu, Susan R. Rheingold, James A. Whitlock, Meenakshi Devidas, Caroline A. Hastings, Naomi J. Winick, William L. Carroll, Brent L. Wood, Michael J. Borowitz, Michael A. Pulsipher, Stephen P. Hunger

https://doi.org/10.3324/haematol.2019.237230

Acute Myeloid Leukemia

Measurable residual disease monitoring provides insufficient lead-time to prevent morphologic relapse in the majority of patients with core-binding factor acute myeloid leukemia (3260 Online Views)

Robert Puckrin, Eshetu G. Atenafu, Jaime O. Claudio, Steven Chan, Vikas Gupta, Dawn Maze, Caroline McNamara, Tracy Murphy, Andre C. Shuh, Karen Yee, Hassan Sibai, Mark D. Minden, Cuihong Wei, Tracy Stockley, Suzanne Kamel-Reid, Aaron D. Schimmer

https://doi.org/10.3324/haematol.2019.235721

Bone Marrow Failure

Utility of clinical comprehensive genomic characterization for diagnostic categorization in patients presenting with hypocellular bone marrow failure syndromes (3421 Online Views)

Piers Blombery, Lucy Fox, Georgina L. Ryland, Ella R. Thompson, Jennifer Lickiss, Michelle McBean, Satwica Yerneni, David Hughes, Anthea Greenway, Francoise Mechinaud, Erica M. Wood, Graham J. Lieschke, Jeff Szer, Pasquale Barbaro, John Roy, Joel Wight, Elly Lynch, Melissa Martyn, Clara Gaff, David Ritchie

https://doi.org/10.3324/haematol.2019.237693

Cell Therapy and Immunotherapy

Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis (2722 Online Views)

Valentina Capo, Sara Penna, Ivan Merelli, Matteo Barcella, Serena Scala, Luca Basso-Ricci, Elena Draghici, Eleonora Palagano, Erika Zonari, Giacomo Desantis, Paolo Uva, Roberto Cusano, Lucia Sergi Sergi, Laura Crisafulli, Despina Moshous, Polina Stepensky, Katarzyna Drabko, Zühre Kaya, Ekrem Unal, Alper Gezdirici, Giuseppe Menna, Marta Serafini, Alessandro Aiuti, Silvia Laura Locatelli, Carmelo Carlo-Stella, Ansgar S. Schulz, Francesca Ficara, Cristina Sobacchi, Bernhard Gentner, Anna Villa

https://doi.org/10.3324/haematol.2019.238261

Chronic Lymphocytic Leukemia

Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study (5658 Online Views)

Alexander C. Leeksma, Panagiotis Baliakas, Theodoros Moysiadis, Anna Puiggros, Karla Plevova, Anne-Marie van der Kevie-Kersemaekers, Hidde Posthuma, Ana E. Rodriguez-Vicente, Anh Nhi Tran, Gisela Barbany, Larry Mansouri, Rebeqa Gunnarsson, Helen Parker, Eva van den Berg, Mar Bellido, Zadie Davis, Meaghan Wall, Ilaria Scarpelli, Anders Österborg, Lotta Hansson, Marie Jarosova, Paolo Ghia, Pino Poddighe, Blanca Espinet, Sarka Pospisilova, Constantine Tam, Loïc Ysebaert, Florence Nguyen-Khac, David Oscier, Claudia Haferlach, Jacqueline Schoumans, Marian Stevens-Kroef, Eric Eldering, Kostas Stamatopoulos, Richard Rosenquist, Jonathan C. Strefford, Clemens Mellink, Arnon P. Kater

https://doi.org/10.3324/haematol.2019.239947

Chronic Myeloid Leukemia

The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission (2963 Online Views)

Sandrine Jeanpierre, Kawtar Arizkane, Supat Thongjuea, Elodie Grockowiak, Kevin Geistlich, Lea Barral, Thibault Voeltzel, Anissa Guillemin, Sandrine Gonin-Giraud, Olivier Gandrillon, Franck-Emmanuel Nicolini, Adam J. Mead, Véronique Maguer-Satta, Sylvain Lefort

https://doi.org/10.3324/haematol.2019.232793

Coagulation & its Disorders

Inhibitor incidence in an unselected cohort of previously untreated patients with severe haemophilia B: a PedNet study (3928 Online Views)

Christoph Male, Nadine G. Andersson, Anne Rafowicz, Ri Liesner, Karin Kurnik, Kathelijn Fischer, Helen Platokouki, Elena Santagostino, Hervé Chambost, Beatrice Nolan, Christoph Königs, Gili Kenet, Rolf Ljung, Marijke van den Berg, PedNet study group

https://doi.org/10.3324/haematol.2019.239160

Hematopoiesis

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development (4219 Online Views)

Matthias De Decker, Marieke Lavaert, Juliette Roels, Laurentijn Tilleman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Pieter Van Vlierberghe, Tom Taghon

https://doi.org/10.3324/haematol.2019.226126

Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins (1655 Online Views)

Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, Ignacio García-Tuñón, Manuel Sánchez-Martín, Ángel Hernández-Hernández

https://doi.org/10.3324/haematol.2019.233064

Hodgkin Lymphoma

Targeted genotyping of circulating tumor DNA for classical Hodgkin lymphoma monitoring: a prospective study (4057 Online Views)

Vincent Camus, Mathieu Viennot, Justine Lequesne, Pierre-Julien Viailly, Elodie Bohers, Lucile Bessi, Bénédicte Marcq, Pascaline Etancelin, Sydney Dubois, Jean-Michel Picquenot, Elena-Liana Veresezan, Marie Cornic, Lucie Burel, Justine Loret, Stéphanie Becker, Pierre Decazes, Pascal Lenain, Stéphane Lepretre, Emilie Lemasle, Hélène Lanic, Anne-Lise Ménard, Nathalie Contentin, Hervé Tilly, Aspasia Stamatoullas, Fabrice Jardin

https://doi.org/10.3324/haematol.2019.237719

Non-Hodgkin Lymphoma

Tandem autologous hematopoietic stem cell transplantation for treatment of adult T-cell lymphoblastic lymphoma: a multiple center prospective study in China (2373 Online Views)

Yao Liu, Jun Rao, Jiali Li, Qin Wen, Sanbin Wang, Shifeng Lou, Tonghua Yang, Bin Li, Lei Gao, Cheng Zhang, Peiyan Kong, Li Gao, Maihong Wang, Lidan Zhu, Xixi Xiang, Sha Zhou, Xue Liu, Xiangui Peng, Jiangfan Zhong, Xi Zhang

https://doi.org/10.3324/haematol.2019.226985

Plasma Cell Disorders

Preclinical development of a humanized chimeric antigen receptor against B cell maturation antigen for multiple myeloma (4396 Online Views)

Lorena Perez-Amill, Guillermo Suñe, Asier Antoñana-Vildosola, Maria Castella, Amer Najjar, Jaume Bonet, Narcis Fernández-Fuentes, Susana Inogés, Ascensión López, Clara Bueno, Manel Juan, Álvaro Urbano-Ispizua, Beatriz Martín-Antonio

https://doi.org/10.3324/haematol.2019.228577

Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma (3454 Online Views)

Daniele Caracciolo, Francesca Scionti, Giada Juli, Emanuela Altomare, Gaetanina Golino, Katia Todoerti, Katia Grillone, Caterina Riillo, Mariamena Arbitrio, Michelangelo Iannone, Eugenio Morelli, Nicola Amodio, Maria Teresa Di Martino, Marco Rossi, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone

https://doi.org/10.3324/haematol.2019.240713

Platelet Biology & its Disorders

Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan (2607 Online Views)

Irene Marini, Jan Zlamal, Christoph Faul, Ursula Holzer, Stefanie Hammer, Lisann Pelzl, Wolfgang Bethge, Karina Althaus, Tamam Bakchoul

https://doi.org/10.3324/haematol.2019.236117

Low-dose Btk inhibitors selectively block platelet activation by CLEC-2 (4027 Online Views)

Phillip L.R. Nicolson, Sophie H. Nock, Joshua Hinds, Lourdes Garcia-Quintanilla, Christopher W. Smith, Joana Campos, Alexander Brill, Jeremy A. Pike, Abdullah O. Khan, Natalie S. Poulter, Diedre M. Kavanagh, Stephanie Watson, Callum N. Watson, Hayley Clifford, Aarnoud P. Huissoon, Alice Y. Pollitt, Johannes A. Eble, Guy Pratt, Steve P. Watson, Craig E. Hughes

https://doi.org/10.3324/haematol.2019.218545

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance (2805 Online Views)

Yingchun Wang, Wenchun Chen, Wei Zhang, Melissa M. Lee-Sundlov, Caterina Casari, Michael C. Berndt, Francois Lanza, Wolfgang Bergmeier, Karin M. Hoffmeister, X. Frank Zhang, Renhao Li

https://doi.org/10.3324/haematol.2019.240440

Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria (9129 Online Views)

Robert A. Brodsky, Régis Peffault de Latour, Scott T. Rottinghaus, Alexander Röth, Antonio M. Risitano, Ilene C. Weitz, Peter Hillmen, Jaroslaw P. Maciejewski, Jeff Szer, Jong Wook Lee, Austin G. Kulasekararaj, Lori Volles, Andrew I. Damokosh, Stephan Ortiz, Lori Shafner, Peng Liu, Anita Hill, Hubert Schrezenmeier

https://doi.org/10.3324/haematol.2019.236877

AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes (5118 Online Views)

Minke A.E. Rab, Brigitte A. van Oirschot, Penelope A. Kosinski, Jeffrey Hixon, Kendall Johnson, Victor Chubukov, Lenny Dang, Gerard Pasterkamp, Stephanie van Straaten, Wouter W. van Solinge, Eduard J. van Beers, Charles Kung, Richard van Wijk

https://doi.org/10.3324/haematol.2019.238865

Letters to the Editor

FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia (2190 Online Views)

Peter A. A. Norris, George B. Segel, W. Richard Burack, Ulrich J. Sachs, Suzanne N. Lissenberg-Thunnissen, Gestur Vidarsson, Behnaz Bayat, Christine M. Cserti-Gazdewich, Jeannie Callum, Yulia Lin, Donald Branch, Rick Kapur, John W. Semple, Alan H. Lazarus

https://doi.org/10.3324/haematol.2020.248385

Impact and safety of chimeric antigen receptor T-cell therapy in older, vulnerable patients with relapsed/refractory large B-cell lymphoma (3267 Online Views)

Richard J. Lin, Stephanie M. Lobaugh, Martina Pennisi, Hei Ton Chan, Yakup Batlevi, Josel D. Ruiz, Theresa A. Elko, Molly A. Maloy, Connie L. Batlevi, Parastoo B. Dahi, Sergio A. Giralt, Paul A. Hamlin, Elena Mead, Arela Noy, M. Lia Palomba, Bianca D. Santomasso, Craig S. Sauter, Michael Scordo, Gunjan L. Shah, Beatriz Korc-Grodzicki, Soo Jung Kim, Mari Lynne Silverberg, Chelsea A. Brooklyn, Sean M. Devlin, Miguel-Angel Perales

https://doi.org/10.3324/haematol.2019.243246

Macrophage-HFE controls iron metabolism and immune responses in aged mice (1882 Online Views)

Naveen Kumar Tangudu, Dilay Yilmaz, Katharina Wörle, Andreas Gruber, Silvia Colucci, Kerstin Leopold, Martina U. Muckenthaler, Maja Vujic Spasic

https://doi.org/10.3324/haematol.2019.235630

Factor IX alteration p.Arg338Gln (FIX Shanghai) potentiates FIX clotting activity and causes thrombosis (2085 Online Views)

Wenman Wu, Lin Xiao, Xi Wu, Xiaoling Xie, Ping Li, Changming Chen, Zhaoyue Zheng, Jiangang Ai, C. Alexander Valencia, Birong Dong, Qiulan Ding, Biao Dong, Xuefeng Wang

https://doi.org/10.3324/haematol.2019.216713

Impact of graft composition on outcomes of haploidentical bone marrow stem cell transplantation (2041 Online Views)

Rima M. Saliba, Lauren Veltri, Gabriela Rondon, Julianne Chen, Gheath Al-Atrash, Amin Alousi, Charles Martinez, LaJerald Augustine, Chitra M. Hosing, Betul Oran, Katayoun Rezvani, Elisabeth J. Shpall, Partow Kebriaei, Issa F. Khouri, Uday Popat, Richard E. Champlin, Stefan O. Ciurea

https://doi.org/10.3324/haematol.2019.227371

T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients (1159 Online Views)

Javier Sánchez-Céspedes, José Antonio Marrugal-Lorenzo, Cecilia Martín-Gandul, Nancy Rodríguez-Torres, Enrique Montero-Mateos, Ana Serna-Gallego, Virginia Escamilla-Gómez, Laura Merino, Ildefonso Espigado, Jerónimo Pachón, José Antonio Pérez-Simón, Manuela Aguilar-Guisado

https://doi.org/10.3324/haematol.2019.240101

SIRPαFc treatment targets human acute myeloid leukemia stem cells (1296 Online Views)

Oleksandr Galkin, Jessica McLeod, James A. Kennedy, Liqing Jin, Nathan Mbong, Mark Wong, Robert A. Uger, Mark D. Minden, Jayne S. Danska, Jean C.Y. Wang

https://doi.org/10.3324/haematol.2019.245167

Comparative analysis of targeted novel therapies in relapsed, refractory chronic lymphocytic leukaemia (3211 Online Views)

Toby A. Eyre, Nicole Lamanna, Lindsey E. Roeker, Chaitra S. Ujjani, Brian T. Hill, Paul M. Barr, Erick Lansigan, Bruce D. Cheson, Maryam Yazdy, John N. Allan, Joanna Rhodes, Stephen J. Schuster, Chadi Nabhan, Alan Skarbnik, Lori Leslie, Prioty Islam, Katherine Whitaker, Catherine C. Coombs, Hande H. Tuncer, John M. Pagel, Ryan Jacobs, Allison M. Winter, Neil Bailey, Andrea Sitlinger, Anna H. Schuh, George Follows, Christopher P. Fox, Danielle M. Brander, Mazyar Shadman, Anthony R. Mato

https://doi.org/10.3324/haematol.2019.241539

Platelets from patients with myocardial infarction can activate T cells (1125 Online Views)

Elena E. Solomou, Katerina Katsanaki, Elena Kalyvioti, Vasilios Gizas, Angelos Perperis, Dora Babali, Evgenia Verigou, Haralambos Gogos, George Hahalis, Periklis Davlouros, Dimitrios Alexopoulos

https://doi.org/10.3324/haematol.2019.243402

Elotuzumab, lenalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: Italian, multicenter, retrospective clinical experience with 300 cases outside of controlled clinical trials (2551 Online Views)

Massimo Gentile, Giorgina Specchia, Daniele Derudas, Monica Galli, Cirino Botta, Stefano Rocco, Concetta Conticello, Catello Califano, Nicola Giuliani, Silvia Mangiacavalli, Enrico Attingenti, Alessandra Lombardo, Marino Brunori, Elena Rossi, Elisabetta Antonioli, Roberto Ria, Renato Zambello, Nicola Di Renzo, Giuseppe Mele, Gianpaolo Marcacci, Pellegrino Musto, Silvana Capalbo, Nicola Cascavilla, Claudio Cerchione, Angelo Belotti, Clelia Criscuolo, Giuseppina Uccello, Paola Curci, Ernesto Vigna, Vincenzo Fraticelli, Donatella Vincelli, Angela Bonalumi, Agostina Siniscalchi, Raffaella Stocchi, Massimo Martino, Stelvio Ballanti, Dominella Gangemi, Alfredo Gagliardi, Barbara Gamberi, Alessandra Pompa, Anna Grazia Recchia, Giovanni Tripepi, Annalisa Pitino, Ferdinando Frigeri, Ugo Consoli, Sara Bringhen, Elena Zamagni, Francesca Patriarca, Valerio De Stefano, Francesco Di Raimondo, Salvatore Palmieri, Maria Teresa Petrucci, Massimo Offidani, Mario Boccadoro, Michele Cavo, Fortunato Morabito

https://doi.org/10.3324/haematol.2019.241513

High bias and low precision for estimated versus measured glomerular filtration rate in pediatric sickle cell anemia (1407 Online Views)

Jeffrey D. Lebensburger, Jeffrey Gossett, Rima Zahr, Winfred C. Wang, Kenneth I. Ataga, Jeremie H. Estepp, Guolian Kang, Jane S. Hankins

https://doi.org/10.3324/haematol.2019.242156

Low incidence of EPOR mutations in idiopathic erythrocytosis (1580 Online Views)

Mathilde Filser, Bernard Aral, Fabrice Airaud, Aurélie Chauveau, Aisha Bruce, Yann Polfrit, Anne Thiebaut, Martin Gauthier, Cédric Le Maréchal, Eric Lippert, Stéphane Béziau, Céline Garrec, Betty Gardie, François Girodon

https://doi.org/10.3324/haematol.2019.244160

FcγRIIb-BCR coligation inhibits BCR signaling in chronic lymphocytic leukemia (1811 Online Views)

Rosa Bosch, Alba Mora, Carolina Cuellar, Gerardo Ferrer, Sergey Gorlatov, Josep Nomdedéu, Emili Montserrat, Jorge Sierra, Kanti R. Rai, Nicholas Chiorazzi, Carol Moreno

https://doi.org/10.3324/haematol.2019.245795

Case Reports

Clonal independence of JAK2 and CALR or MPL mutations in comutated myeloproliferative neoplasms demonstrated by single cell DNA sequencing (2976 Online Views)

Ella R. Thompson, Tamia Nguyen, Yamuna Kankanige, Paul Yeh, Michael Ingbritsen, Michelle McBean, Timothy Semple, Gisela Mir Arnau, Kate Burbury, Nora Lee, Amit Khot, David Westerman, Piers Blombery

https://doi.org/10.3324/haematol.2020.260448

Errata Corrige