February, 2021
No. 106 (2)

About the Cover

Editorials

Review Articles

Articles

Transplantation

Standardized monitoring of cytomegalovirus-specific immunity can improve risk stratification of recurrent cytomegalovirus reactivation after hematopoietic stem cell transplantation (2937 Online Views)

Eva Wagner-Drouet, Daniel Teschner, Christine Wolschke, Dietlinde Janson, Kerstin Schäfer-Eckart, Johannes Gärtner, Stephan Mielke, Martin Schreder, Guido Kobbe, Mustafa Kondakci, Inken Hilgendorf, Marie von Lilienfeld-Toal, Stefan Klein, Daniela Heidenreich, Sebastian Kreil, Mareike Verbeek, Sandra Grass, Markus Ditschkowski, Tanja Gromke, Martina Koch, Monika Lindemann, Thomas Hünig, Traudel Schmidt, Anne Rascle, Harald Guldan, Sascha Barabas, Ludwig Deml, Ralf Wagner, Daniel Wolff

https://doi.org/10.3324/haematol.2019.229252

Autologous stem cell transplantation for progressive systemic sclerosis: a prospective non-interventional study from the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party (10229 Online Views)

Joerg Henes, Maria Carolina Oliveira, Myriam Labopin, Manuela Badoglio, Hans Ulrich Scherer, Nicoletta Del Papa, Thomas Daikeler, Marc Schmalzing, Roland Schroers, Thierry Martin, Gregory Pugnet, Belinda Simoes, David Michonneau, Erik W.A. Marijt, Bruno Lioure, Jacques Olivier Bay, John A. Snowden, Montserrat Rovira, Anne Huynh, Francesco Onida, Lothar Kanz, Zora Marjanovic, Dominique Farge

https://doi.org/10.3324/haematol.2019.230128

Iron Metabolism & its Disorders

Induction of erythroferrone in healthy humans by micro-dose recombinant erythropoietin or high-altitude exposure (2169 Online Views)

Paul Robach, Elena Gammella, Stefania Recalcati, Domenico Girelli, Annalisa Castagna, Matthieu Roustit, Carsten Lundby, Anne-Kristine Lundby, Pierre Bouzat, Samuel Vergès, Guillaume Séchaud, Pierluigi Banco, Mario Uhr, Catherine Cornu, Pierre Sallet, Gaetano Cairo

https://doi.org/10.3324/haematol.2019.233874

C-FGF23 peptide alleviates hypoferremia during acute inflammation (2610 Online Views)

Rafiou Agoro, Min Young Park, Carole Le Henaff, Stanislovas Jankauskas, Alina Gaias, Gaozhi Chen, Moosa Mohammadi, Despina Sitara

https://doi.org/10.3324/haematol.2019.237040

Hematopoiesis

A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency (3128 Online Views)

Chantal Lagresle-Peyrou, Aurélien Olichon, Hanem Sadek, Philippe Roche, Claudine Tardy, Cindy Da Silva, Alexandrine Garrigue, Alain Fischer, Despina Moshous, Yves Collette, Capucine Picard, Jean Laurent Casanova, Isabelle André, Marina Cavazzana

https://doi.org/10.3324/haematol.2019.230250

MicroRNA-21 maintains hematopoietic stem cell homeostasis through sustaining the NF-κB signaling pathway in mice (2347 Online Views)

Mengjia Hu, Yukai Lu, Hao Zeng, Zihao Zhang, Shilei Chen, Yan Qi, Yang Xu, Fang Chen, Yong Tang, Mo Chen, Changhong Du, Mingqiang Shen, Fengchao Wang, Yongping Su, Song Wang, Junping Wang

https://doi.org/10.3324/haematol.2019.236927

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress (1570 Online Views)

Michiko Ichii, Kenji Oritani, Jun Toda, Hideaki Saito, Henyun Shi, Hirohiko Shibayama, Daisuke Motooka, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Daisuke Okuzaki, Tadashi Matsuda, Yuzuru Kanakura

https://doi.org/10.3324/haematol.2019.225573

Gaucher Disease

Accuracy of chitotriosidase activity and CCL18 concentration in assessing type I Gaucher disease severity. A systematic review with meta-analysis of individual participant data (1932 Online Views)

Tatiana Raskovalova, Patrick B. Deegan, Pramod K. Mistry, Elena Pavlova, Ruby Yang, Ari Zimran, Juliette Berger, Céline Bourgne, Bruno Pereira, José Labarère, Marc G. Berger

https://doi.org/10.3324/haematol.2019.236083

Complications in Hematology

Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel (3638 Online Views)

Sihe Jiang, Olaf Penack, Tobias Terzer, David Schult, Joshua Majer-Lauterbach, Aleksandar Radujkovic, Igor W. Blau, Lars Bullinger, Carsten Müller-Tidow, Peter Dreger, Thomas Luft

https://doi.org/10.3324/haematol.2019.238790

Leukocyte Biology

Alternative activation of human macrophages enhances tissue factor expression and production of extracellular vesicles (3040 Online Views)

Philipp J. Hohensinner, Julia Mayer, Julia Kichbacher, Julia Kral-Pointner, Barbara Thaler, Christoph Kaun, Lena Hell, Patrick Haider, Marion Mussbacher, Johannes A. Schmid, Stefan Stojkovic, Svitlana Demyanets, Michael B. Fischer, Kurt Huber, Katharina Wöran, Christian Hengstenberg, Walter S. Speidl, Rudolf Oehler, Ingrid Pabinger, Johann Wojta

https://doi.org/10.3324/haematol.2019.220210

Red Cell Biology & its Disorders

Hemoglobin switching in mice carrying the Klf1Nan variant (1945 Online Views)

Anne Korporaal, Nynke Gillemans, Steven Heshusius, Ileana Cantú, Emile van den Akker, Thamar B. van Dijk, Marieke von Lindern, Sjaak Philipsen

https://doi.org/10.3324/haematol.2019.239830

The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene (2370 Online Views)

Cristina Fugazza, Gloria Barbarani, Sudharshan Elangovan, Maria Giuseppina Marini, Serena Giolitto, Isaura Font-Monclus, Maria Franca Marongiu, Laura Manunza, John Strouboulis, Claudio Cantù, Fabio Gasparri, Silvia M.L. Barabino, Yukio Nakamura, Sergio Ottolenghi, Paolo Moi, Antonella Ellena Ronchi

https://doi.org/10.3324/haematol.2019.241224

Chronic Myeloid Leukemia

Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells (2741 Online Views)

Takashi Yahata, Abd Aziz Ibrahim, Ken-ichi Hirano, Yukari Muguruma, Kazuhito Naka, Katsuto Hozumi, Douglas E. Vaughan, Toshio Miyata, Kiyoshi Ando

https://doi.org/10.3324/haematol.2019.230227

Non-Hodgkin Lymphoma

Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma (1913 Online Views)

Aloke Sarkar, Christine M. Stellrecht, Hima V. Vangapandu, Mary Ayres, Benny A. Kaipparettu, Jun Hyoung Park, Kumudha Balakrishnan, Jared K. Burks, Tej K. Pandita, Walter N. Hittelman, Sattva S. Neelapu, Varsha Gandhi

https://doi.org/10.3324/haematol.2019.234385

Cell free circulating tumor DNA in cerebrospinal fluid detects and monitors central nervous system involvement of B-cell lymphomas (4963 Online Views)

Sabela Bobillo, Marta Crespo, Laura Escudero, Regina Mayor, Priyanka Raheja, Cecilia Carpio, Carlota Rubio-Perez, Bárbara Tazón-Vega, Carlos Palacio, Júlia Carabia, Isabel Jiménez, Juan C. Nieto, Julia Montoro, Francisco Martínez-Ricarte, Josep Castellvi, Marc Simó, Lluis Puigdefàbregas, Pau Abrisqueta, Francesc Bosch, Joan Seoane

https://doi.org/10.3324/haematol.2019.241208

Coagulation & its Disorders

Acute Lymphoblastic Leukemia

Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma (2677 Online Views)

Shingo Nakahata, Chilmi Syahrul, Ayako Nakatake, Kuniyo Sakamoto, Maki Yoshihama, Ichiro Nishikata, Yoshinori Ukai, Tadashi Matsuura, Takuro Kameda, Kotaro Shide, Yoko Kubuki, Tomonori Hidaka, Akira Kitanaka, Akihiko Ito, Shigeki Takemoto, Nobuaki Nakano, Masumichi Saito, Masako Iwanaga, Yasuko Sagara, Kosuke Mochida, Masahiro Amano, Kouichi Maeda, Eisaburo Sueoka, Akihiko Okayama, Atae Utsunomiya, Kazuya Shimoda, Toshiki Watanabe, Kazuhiro Morishita

https://doi.org/10.3324/haematol.2019.234096

Chronic Lymphocytic Leukemia

Bendamustine, followed by ofatumumab and ibrutinib in chronic lymphocytic leukemia (CLL2-BIO): primary endpoint analysis of a multicenter, open-label phase-II trial (2195 Online Views)

Paula Cramer, Julia v. Tresckow, Sandra Robrecht, Jasmin Bahlo, Moritz Fürstenau, Petra Langerbeins, Natali Pflug, Othman Al-Sawaf, Werner J. Heinz, Ursula Vehling-Kaiser, Jan Dürig, Eugen Tausch, Manfred Hensel, Stephanie Sasse, Anna-Maria Fink, Kirsten Fischer, Karl-Anton Kreuzer, Sebastian Böttcher, Matthias Ritgen, Michael Kneba, Clemens-Martin Wendtner, Stephan Stilgenbauer, Barbara Eichhorst, Michael Hallek

https://doi.org/10.3324/haematol.2019.223693

Myelodysplastic Syndromes

Acute Myeloid Leukemia

Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia (2326 Online Views)

Anuhar Chaturvedi, Charu Gupta, Razif Gabdoulline, Nora M. Borchert, Ramya Goparaju, Stefan Kaulfuss, Kerstin Görlich, Renate Schottmann, Basem Othman, Julia Welzenbach, Olaf Panknin, Markus Wagner, Robert Geffers, Arnold Ganser, Felicitas Thol, Michael Jeffers, Andrea Haegebarth, Michael Heuser

https://doi.org/10.3324/haematol.2019.236992

Letters to the Editor

Novel L-nucleoside analogue, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia (1215 Online Views)

Aniket Bankar, Thirushi Piyumika Siriwardena, Biljana Rizoska, Christina Rydergård, Helen Kylefjord, Vilma Rraklli, Anders Eneroth, Pedro Pinho, Stefan Norin, Johan Bylund, Sara Moses, Richard Bethell, Simon Kavanagh, Neil Maclean, Marcela Gronda, Xiaoming Wang, Rose Hurren, Mark D. Minden, Paul Targett-Adams, Aaron D. Schimmer, Mark Albertella

https://doi.org/10.3324/haematol.2019.226795

Wip1 regulates hematopoietic stem cell development in the mouse embryo (1257 Online Views)

Wenyan He, Xiaobo Wang, Yanli Ni, Zongcheng Li, Wei Liu, Zhilin Chang, Haowen Li, Zhenyu Ju, Zhuan Li

https://doi.org/10.3324/haematol.2019.235481

CD4+ T-cell alloreactivity after haploidentical hematopoietic stem cell transplantation (1320 Online Views)

Burak Kalin, Elisabetta Metafuni, Mariëtte ter Borg, Rebecca Wijers, Eric Braakman, Cor H.J. Lamers, Andrea Bacigalupo, Jan J. Cornelissen

https://doi.org/10.3324/haematol.2019.244152

Daratumumab inhibits acute myeloid leukaemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells (2623 Online Views)

Jayna J. Mistry, Jamie A. Moore, Prakritt Kumar, Christopher R. Marlein, Charlotte Hellmich, Genevra Pillinger, Aisha Jibril, Federica Di Palma, Angela Collins, Kristian M. Bowles, Stuart A. Rushworth

https://doi.org/10.3324/haematol.2019.242974

Clinicopathological and genetic features of limited-stage diffuse large B-cell lymphoma with late relapse: targeted sequencing analysis of gene alterations in the initial and late relapsed tumors (1253 Online Views)

Tomotaka Suzuki, Suguru Fukuhara, Junko Nomoto, Satoshi Yamashita, Akiko (Miyagi) Maeshima, Yuta Ito, Shunsuke Hatta, Sayako Yuda, Shinichi Makita, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Hirokazu Taniguchi, Toshikazu Ushijima, Koji Izutsu, Kensei Tobinai, Yukio Kobayashi

https://doi.org/10.3324/haematol.2019.235598

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis (1641 Online Views)

Zuzana Chyra, Tereza Sevcikova, Petr Vojta, Janka Puterova, Lucie Brozova, Katerina Growkova, Jana Filipova, Martina Zatopkova, Sebastian Grosicki, Agnieszka Barchnicka, Wieslaw Wiktor Jedrzejczak, Anna Waszczuk-Gajda, Alexandra Jungova, Aneta Mikulasova, Marian Hajduch, Martin Mokrejs, Ludek Pour, Martin Stork, Lubica Harvanova, Martin Mistrik, Gabor Mikala, Pawel Robak, Anna Czyz, Jakub Debski, Lidia Usnarska-Zubkiewicz, Artur Jurczyszyn, Lukas Stejskal, Gareth Morgan, Fedor Kryukov, Eva Budinska, Michal Simicek, Tomas Jelinek, Matous Hrdinka, Roman Hajek

https://doi.org/10.3324/haematol.2019.239756

Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia (2378 Online Views)

Aoli Wang, Chen Hu, Cheng Chen, Xiaofei Liang, Beilei Wang, Fengming Zou, Kailin Yu, Feng Li, Qingwang Liu, Ziping Qi, Junjie Wang, Wenliang Wang, Li Wang, Ellen L. Weisberg, Wenchao Wang, Lili Li, Jian Ge, Ruixiang Xia, Jing Liu, Qingsong Liu

https://doi.org/10.3324/haematol.2019.244186

miR-939 acts as tumor suppressor by modulating JUNB transcriptional activity in pediatric anaplastic large cell lymphoma (1139 Online Views)

Anna Garbin, Federica Lovisa, Antony B. Holmes, Carlotta C. Damanti, Ilaria Gallingani, Elisa Carraro, Benedetta Accordi, Giulia Veltri, Marco Pizzi, Emanuele S.G. d'Amore, Marta Pillon, Alessandra Biffi, Katia Basso, Lara Mussolin

https://doi.org/10.3324/haematol.2019.241307

Myeloid/lymphoid neoplasms with eosinophilia/ basophilia and ETV6-ABL1 fusion: cell-of-origin and response to tyrosine kinase inhibition (2227 Online Views)

JinJuan Yao, Lianrong Xu, Umut Aypar, Howard J. Meyerson, Dory Londono, Qi Gao, Jeeyeon Baik, James Dietz, Ryma Benayed, Allison Sigler, Mariko Yabe, Ahmet Dogan, Maria E. Arcila, Mikhail Roshal, Yanming Zhang, Michael J. Mauro, Wenbin Xiao

https://doi.org/10.3324/haematol.2020.249649

SMAD1 promoter hypermethylation and lack of SMAD1 expression in Hodgkin lymphoma: a potential target for hypomethylating drug therapy (1258 Online Views)

Magdalena M. Gerlach, Anna Stelling-Germani, Cheuk Ting Wu, Sebastian Newrzela, Claudia Döring, Visar Vela, Anne Müller, Sylvia Hartmann, Alexandar Tzankov

https://doi.org/10.3324/haematol.2020.249276

Efficacy of recombinant erythropoietin in autoimmune hemolytic anemia: a multicenter international study (5250 Online Views)

Bruno Fattizzo, Marc Michel, Anna Zaninoni, Juri Giannotta, Stephanie Guillet, Henrik Frederiksen, Josephine M.I. Vos, Francesca R. Mauro, Bernd Jilma, Andrea Patriarca, Francesco Zaja, Anita Hill, Sigbiørn Berentsen, Wilma Barcellini

https://doi.org/10.3324/haematol.2020.250522

Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2 (3198 Online Views)

Joshua H. Bourne, Martina Colicchia, Ying Di, Eleyna Martin, Alexander Slater, Lubka T. Roumenina, Jordan D. Dimitrov, Steve P. Watson, Julie Rayes

https://doi.org/10.3324/haematol.2020.246488

The clinical and biological characteristics of NUP98-KDM5A in pediatric acute myeloid leukemia (3829 Online Views)

Sanne Noort, Priscilla Wander, Todd A. Alonzo, Jenny Smith, Rhonda E. Ries, Robert B. Gerbing, M. Emmy M. Dolman, Franco Locatelli, Dirk Reinhardt, Andre Baruchel, Jan Stary, Jan J. Molenaar, Ronald W. Stam, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Soheil Meshinchi

https://doi.org/10.3324/haematol.2019.236745

Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation (2287 Online Views)

Yoko Nishinaka-Arai, Akira Niwa, Shiori Matsuo, Yasuhiro Kazuki, Yuwna Yakura, Takehiko Hiroma, Tsutomu Toki, Tetsushi Sakuma, Takashi Yamamoto, Etsuro Ito, Mitsuo Oshimura, Tatsutoshi Nakahata, Megumu K. Saito

https://doi.org/10.3324/haematol.2019.242693

Case Reports

Emapalumab treatment in an ADA-SCID patient with refractory hemophagocytic lymphohistiocytosis- related graft failure and disseminated bacillus Calmette-Guérin infection (2552 Online Views)

Francesca Tucci, Vera Gallo, Federica Barzaghi, Francesca Ferrua, Maddalena Migliavacca, Valeria Calbi, Matteo Doglio, Elena Sophia Fratini, Zeynep Karakas, Sukru Guner, Matilde Zambelli, Cristina Parisi, Raffaella Milani, Salvatore Gattillo, Benedetta Mazzi, Chiara Oltolini, Maurizio Barbera, Cristina Baldoli, Daniela Maria Cirillo, Veronica Asnaghi, Cristina De Min, Maria Pia Cicalese, Fabio Ciceri, Alessandro Aiuti, Maria Ester Bernardo

https://doi.org/10.3324/haematol.2020.255620

Detectable mutations precede late myeloid neoplasia in aplastic anemia (2397 Online Views)

Bhavisha A. Patel, Jack Ghannam, Emma M. Groarke, Meghali Goswami, Laura Dillon, Fernanda Gutierrez-Rodrigues, Olga Rios, Diego Quinones Raffo, Jennifer Lotter, Neal S. Young, Christopher S. Hourigan

https://doi.org/10.3324/haematol.2020.263046

A deep molecular response of splenic marginal zone lymphoma to front-line checkpoint blockade (1820 Online Views)

Peter G. Miller, Adam S. Sperling, Christopher J. Gibson, Olga Pozdnyakova, Waihay J. Wong, Michael P. Manos, Elizabeth I. Buchbinder, F. Stephen Hodi, Benjamin L. Ebert, Matthew S. Davids

https://doi.org/10.3324/haematol.2020.258426