Articles

AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes

Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands;
Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands;
Agios Pharmaceuticals, Inc., Cambridge, MA, USA;
KSQ Therapeutics, Cambridge, MA, USA;
Agios Pharmaceuticals, Inc., Cambridge, MA, USA;
Agios Pharmaceuticals, Inc., Cambridge, MA, USA;
Agios Pharmaceuticals, Inc., Cambridge, MA, USA;
Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands;
Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands;
Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands;
Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
Agios Pharmaceuticals, Inc., Cambridge, MA, USA;
Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands;
Haematologica Early view Jan 23, 2020 https://doi.org/10.3324/haematol.2019.238865