CURRENT ISSUE
April, 2026
No. 111 (4)

Landmark papers in Hematology

1

Pro and Con Article

2

Editorials

7

Review Articles

1

JAK inhibitor selection in challenging scenarios of myelofibrosis: a review (1793 Online Views)

Pankit Vachhani, Ruben Mesa, John Mascarenhas, Raajit Rampal, Stephen T. Oh, Alessandro Maria Vannucchi, Maria Laura Fox, Francesca Palandri, Francesco Passamonti, Jean-Jacques Kiladjian, Mahshid Azimi, Claire Harrison, Prithviraj Bose

https://doi.org/10.3324/haematol.2025.288654

Spotlight Review

1

Perspective Articles

1

Articles

16
Acute Myeloid Leukemia

Age-specific mutation profiles and their prognostic implications in pediatric KMT2A-rearranged acute myeloid leukemia (1174 Online Views)

Kota Shoji, Kenichi Yoshida, Shinju Iyoda, Moe Ishikawa, Miu Tanaka, Michidai Nobe, Nijika Saito, Yuto Shino, Yasuhito Nannya, Genki Yamato, Shinichi Tsujimoto, Norio Shiba, Yasuhide Hayashi, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Ai Okada, Hiroko Tanaka, Satoru Miyano, Yuhki Koga, Hiroaki Goto, Kiminori Terui, Etsuro Ito, Nobutaka Kiyokawa, Daisuke Tomizawa, Takashi Taga, Hiroshi Moritake, Akio Tawa, Junko Takita, Momoko Nishikori, Souichi Adachi, Seishi Ogawa, Hidemasa Matsuo

https://doi.org/10.3324/haematol.2025.288481

Long-term outcomes in FLT3-mutated acute myeloid leukemia after frontline hypomethylating agent, venetoclax and a FLT3 inhibitor (2106 Online Views)

Nicholas J. Short, Sanam Loghavi, Musa Yilmaz, Omer Karrar, Kunhwa Kim, Courtney D. Dinardo, Tapan M. Kadia, Manuel Maroun, Gautam Borthakur, Ghayas C. Issa, Joseph Jabbour, Betul Oran, Elizabeth J. Shpall, Uday Popat, Keyur P. Patel, Mark Routbort, Marina Konopleva, Farhad Ravandi, Hagop Kantarjian, Naval Daver

https://doi.org/10.3324/haematol.2025.288553

The comprehensive landscape of TTMV::RARA fusiondriven acute myeloid leukemia: from viral integration mechanisms to clinical outcomes (1020 Online Views)

Shu Sun, Yongjing Liu, Qing-Yu Xu, Jiayu Wang, Li Chen, Zhanrui Cheng, Wei Gao, Huili Wang, Bei Yang, Haiyan Wang, Lijun Wen, Jian Xiao, Jiacheng Lou, Haibo Yu, Na Li, Feng Wang, Yangyang Xie, JinGang Wang, Xianjing Wang, Hongjuan Xue, Kun Chen, Yin Wu, Leping Zhang, Ke Li, Shuhong Shen, Suning Chen, Huan-You Wang, KanKan Wang, Jinyan Huang, Hong-Hu Zhu

https://doi.org/10.3324/haematol.2025.288721

Cell Therapy & Immunotherapy

Human cytomegalovirus control in allogeneic stem cell transplant recipients in the letermovir era – emerging humoral and cellular players (818 Online Views)

Chris D. Lauruschkat, Hannah Görge, Kerstin Knies, Benedikt Weißbrich, Lars Dölken, Carolin Köchel, Nina Imhof, Magdalena Huber, Hartmut Hengel, Hermann Einsele, Sebastian Wurster, Sabrina Kraus

https://doi.org/10.3324/haematol.2025.288237

Chronic Myeloid Leukemia

Children with chronic-phase chronic myeloid leukemia: characteristics and outcomes from the International Registry of Childhood CML (861 Online Views)

Frédéric Millot, Joe de Keizer, Markus Metzler, Krzysztof Kalwak, Adalet Meral Günes, Barbara De Moerloose, Maaike Luesink, Antonio Molines Honrubia, Petr Sedlacek, Julia Yajima, Mirella Ampatzidou, Michael Dworzak, Birgitte Lausen, Marina Borisevich, Chi Kong Li, Alexandra Kolenova, Gordana Jakovljevic, Roula Farah, Lisa Durocher, André Baruchel, Meinolf Suttorp

https://doi.org/10.3324/haematol.2025.288283

Coagulation & its Disorders

Divergent processing of FVIII light chain variants: secretory potential versus proteasomal retention (670 Online Views)

Heike Singer, Payal Chawla, Katrin J. Czogalla-Nitsche, Pujan Engels, Francesco Forin, Marc Sylvester, Melanie Rath, Jens Müller, Tobias Feist, Behnaz Pezeshkpoor, Rawya Al-Rifai, Osman El-Maarri, Johannes Oldenburg

https://doi.org/10.3324/haematol.2025.288250

Hematopoiesis

Protein phosphatase 2A orchestrates hematopoietic fate determination via modulation of lactate metabolism (1364 Online Views)

Can Liu, Yao Meng, Heng Chen, Siqi Bi, Ye Tian, Zhihua Yin, Guanhua Li, Wutao Chen, Li Wu, You Wang, Nan Shen, Haibo Zhou

https://doi.org/10.3324/haematol.2025.288868

Hemostasis

Thrombin generation to predict breakthrough bleeding in patients with acquired hemophilia A under emicizumab prophylaxis (800 Online Views)

Fabius J. Pelzer, Ella I. Ertekin, Olga Oleshko, Annika Klingberg, Paul Knöbl, Christian Pfrepper, Richard Greil, Johannes Oldenburg, Ulrich J. Sachs, Wolfgang Miesbach, Karolin Trautmann-Grill, Katharina Holstein, Hermann Eichler, Patrick Möhnle, Christina Hart, Robert Klamroth, Andreas Tiede, Sonja Werwitzke

https://doi.org/10.3324/haematol.2025.288115

Leukocyte Biology & its Disorders

The dual non-competitive CXCR1/2 inhibitor ladarixin impairs neutrophil extravasation without altering intravascular adhesion (1614 Online Views)

Matteo Napoli, Sebastian Sitaru, Agnes Budke, Anna Kammerl, Georgia Querner, Roland Immler, Ina Rohwedder, Sonja Seifert, Bartolo Ferraro, Ludwig Weckbach, Sergio Catz, Andrea Aramini, Pier Giorgio Amendola, Marcello Allegretti, Riccardo Bertini, Monika Pruenster, Markus Sperandio

https://doi.org/10.3324/haematol.2025.287877

Myelodysplastic Syndromes

TGFβ-activated kinase-1 knockdown in hematopoietic stem-progenitor cells causes PANoptosis and myelodysplastic syndrome-like disease in mice (935 Online Views)

Lei Zhang, Wenyan Li, Rohit Thalla, Rongyao Ma, Ryan Mack, Ameet R. Kini, Austin Runde, Patrick A. Hagen, Kevin Barton, Jorgena Kosti-Schwartz, Peter Breslin, Hong-Long Ji, Jiwang Zhang

https://doi.org/10.3324/haematol.2025.287951

Myeloproliferative Disorders

Clonal megakaryocyte dysplasia with normal blood values: a covert, thrombosis-prone, early myeloproliferative neoplasm (731 Online Views)

Giovanni Barosi, Vittorio Rosti, Rita Campanelli, Margherita Massa, Carlotta Abbà, Adriana Carolei, Paolo Catarsi, Alessandro Inzoli, Lorena Pergola, Tiziano Barbui, Caterina Tatarelli, Maria Chiara Finazzi, Annalisa Condorelli, Silvia Salmoiraghi, Alessandro Rambaldi, Andrea Gianatti, Valerio De Stefano, Anna Gallì, Martina Gandossini, Michela Bardelli, Robert Peter Gale, Luca Malcovati

https://doi.org/10.3324/haematol.2025.288681

Non-Hodgkin Lymphoma

Outcomes of patients with relapsed or refractory primary mediastinal B-cell lymphoma after frontline DA-EPOCH-R (1163 Online Views)

Brian Hess, Alison Moskowitz, James A. Davis, Paolo Strati, Yazeed Sawalha, Jonathan Bakos, Mckenzie Sorrell, Anna C. Ferreira, Silvia Escribano-Serrat, Michelly De Castro, Taylor R. Brooks, Brian T. Hill, Gunjan L. Shah, Ayo S. Falade, Reid Merryman, Manali Kamdar, Andrew Ip, Victoria Nachar, Joseph G. Bennett, Nicole Lux, Nausheen Ahmed, Marc Hoffmann, Ann LaCasce

https://doi.org/10.3324/haematol.2025.288232

Platelet Biology & its Disorders

Novel cryptic ADAMTS13 epitopes uncover a distinct open ADAMTS13 conformation in immune-mediated TTP (748 Online Views)

Quintijn Bonnez, Febe Boudry, Laure De Waele, Lisa Vermeersch, Kadri Kangro, Inge Pareyn, Edwige Tellier, Gilles Kaplanski, Claudia Tersteeg, Bérangère S. Joly, Paul Coppo, Agnès Veyradier, Simon F. De Meyer, Karen Vanhoorelbeke

https://doi.org/10.3324/haematol.2025.288097

Letters to the Editor

15

Role of donor regulatory T-cell adoptive immunotherapy in B-cell immunity after hematopoietic cell transplantation (511 Online Views)

Sara Piccinelli, Roberto Limongello, Valerio Viglione, Eni Hohxa, Tiziana Zei, Roberta Iacucci Ostini, Barbara Bigerna, Alessia Tabarrini, Rebecca Sembenico, Sara Tricarico, Francesco Zorutti, Maria Paola Martelli, Alessandra Carotti, Massimo Fabrizio Martelli, Andrea Velardi, Loredana Ruggeri, Antonella Mancusi, Antonio Pierini

https://doi.org/10.3324/haematol.2024.286905

Talquetamab, a GPRC5D×CD3 bispecific antibody, in Chinese patients with relapsed/refractory multiple myeloma: efficacy and safety from the phase 1/2 MonumenTAL-1 study (1212 Online Views)

Gang An, Jie Jin, Zhen Cai, Hongmei Jing, Chengcheng Fu, Pengcheng He, Zhongjun Xia, Rui Liu, Liang Li, Xue Gai, Hong Zhang, Dian Zhu, Xinchao Luo, Binbin Sun, Hongmei Xu, Longen Zhou, Michela Campagna, Tara J. Masterson, Bonnie W. Lau, Thomas Renaud, Christoph Heuck, Indrajeet Singh, Deeksha Vishwamitra, Lugui Qiu

https://doi.org/10.3324/haematol.2025.287334

Recovery of spermatogenesis following bone marrow transplantation (374 Online Views)

Joseph Daniele, Sasha Savkovic, Amanda Idan, Ting Zhang, Veena Jayadev, Ann J. Conway, David J. Handelsman

https://doi.org/10.3324/haematol.2025.288089

Clinical outcomes of WHO2022 and ICC MDS entities with risk stratification by IPSS-R and IPSS-M (559 Online Views)

Daehun Kwag, Byunggyu Bae, Jin Jung, Hoon Seok Kim, Jong-Mi Lee, Ari Ahn, Ji Sang Yoon, So Yeon Park, Silvia Park, Myungshin Kim, Yoo-Jin Kim, Yonggoo Kim

https://doi.org/10.3324/haematol.2025.288090

Identification of a novel MYO1F::MLLT10 fusion in adult acute monocytic leukemia (445 Online Views)

Bhaumik Shah, Roniya Francis, Jianming Pei, Ryan Neumann-Domer, Nicholas Mackrides, Joseph R. Testa, Reza Nejati

https://doi.org/10.3324/haematol.2025.288255

Ixazomib maintenance therapy in transplant-eligible multiple myeloma: real-world evidence from three large German centers (917 Online Views)

Peter May, Michael Rassner, Marion Hoegner, Wajma Shahbaz, Ralph Wäsch, Ana M.G. Martinez, Burkhard Schmidt, Sebastian Theurich, Monika Engelhardt, Florian Bassermann, Johannes Jung

https://doi.org/10.3324/haematol.2025.288320

TNF-α signaling drives myeloid skewing and clonal expansion of stem and progenitor cells in RUNX1-familial platelet disorder (663 Online Views)

Mona Mohammadhosseini, Aishwarya Sahasrabudhe, Luiza H. Ostrowski, John McClatchy, Rebekah Knight, Kathryn Schabel, Ryland Kagan, Erica Bresciani, Paul Liu, Anupriya Agarwal

https://doi.org/10.3324/haematol.2025.288410

The impact of daratumumab-containing induction on stem cell mobilization, collection and engraftment in newly diagnosed multiple myeloma: results of the prospective DILEMMA study (729 Online Views)

Caterina Giovanna Valentini, Claudio Pellegrino, Patrizia Chiusolo, Elena Rossi, Rossella Ladiana, Tommaso Za, Simona Sica, Livio Pagano, Valerio De Stefano, Luciana Teofili

https://doi.org/10.3324/haematol.2025.288411

Expanded clinical, genetic, and biological spectrum of filaminopathies with hematological involvement (587 Online Views)

Charlotte Brillon, Marjorie Poggi, Mathieu Fiore, Cyril Goizet, Sophie Bayart, Mélanie Y. Daniel, Jean-Baptiste Valentin, Nathalie Hezard, Johannes Van Agthoven, Véronique Sbarra, Marie Loosveld, Céline Falaise, Marie-Christine Alessi, Manal Ibrahim-Kosta, Paul Saultier

https://doi.org/10.3324/haematol.2025.288445

Clinical and genomic features of macrofocal multiple myeloma: a distinct profile (548 Online Views)

Jin Liu, Jianling Fan, Xinyi Zhou, Xi Chen, Xiaoli Hu, Haiyan He, Lina Jin, Weijun Fu, Jian Hou, Juan Du

https://doi.org/10.3324/haematol.2025.288535

Patient-centered care strategies for Jehovah’s Witnesses with acute leukemia and high-grade myeloid neoplasms (1928 Online Views)

Jabra Zarka, Aref Al-Kali, Hassan B. Alkhateeb, Aasiya Matin, Naseema Gangat, William J. Hogan, James Foran, Hemant Murthy, Cecilia Arana Yi, Dhauna Karam Prasad, Syeda Mina, Mark R. Litzow, Kebede H. Begna, Antoine N. Saliba

https://doi.org/10.3324/haematol.2025.288622

TE-1146, a novel anti-CD38-antibody-lenalidomide conjugate, demonstrates potent ex vivo anti-myeloma activity (704 Online Views)

Shih-Syuan Cheng, Jing-Gu Jiang, Shih-Chiang Lin, Yueh-Hsiang Yu, Tse Wen Chang, Carmay Lim, Yuan-Bin Yu, Hsing-Mao Chu

https://doi.org/10.3324/haematol.2025.288692

Clinical and germline risk factors for multiple treatmentrelated toxicities in pediatric acute lymphoblastic leukemia (598 Online Views)

Marion K. Mateos, Chelsea Mayoh, Patricia Sullivan, Pasquale M. Barbaro, Michael C.J. Quinn, Carly George, Rosemary Sutton, Tom Revesz, Jodie E. Giles, Draga Barbaric, Frank Alvaro, Rachel Conyers, Daniel Catchpoole, Stuart MacGregor, Rishi S. Kotecha, Luciano Dalla-Pozza, Toby N. Trahair, Glenn M. Marshall

https://doi.org/10.3324/haematol.2025.288939

Proteomic analysis of pericardial effusions in hematopoietic stem cell transplant recipients (445 Online Views)

Jane Koo, Aaron Webster, Kelly E. Lake, Nathan Luebbering, Christopher Dandoy, Sonata Jodele, Thomas D. Ryan, Stella M. Davies, Anthony Sabulski

https://doi.org/10.3324/haematol.2025.289076

Case Reports

3

Teclistamab for heavily pretreated relapsed/refractory POEMS syndrome (1807 Online Views)

Alexis Talbot, Nathalie Forgeard, Tristan Vaugeois, Floriane Theves, Sabrine Dimassi, Bruno Royer, Pierre-Edouard Debureaux, Véronique Meignin, Laetitia Vercellino, David Boutboul, Bertrand Arnulf, Stéphanie Harel

https://doi.org/10.3324/haematol.2025.287606

CNS infiltration by zamtocabtagene autoleucel tandem CD20/CD19 CAR T cells leading to complete remission in a patient with primary CNS lymphoma (845 Online Views)

Nancy M. Hardy, Jean A. Yared, Tim Luetkens, Haroon Ahmad, Rediet Mulatu, Daniel Yamoah, Xiaoxuan Fan, Samuel Weeks, Sophia A. Bredar, Ashley Gelin, Jillian M. Baker, Kenneth A. Dietze, Aerielle Matsangos, Ariel Fromowitz, Johanna Theruvath, Louisa Wirthlin, Remigiusz Kaleta, Anna Wijatyk, Rima Koka, Michael E. Kallen, Kim G. Hankey, Aaron P. Rapoport, Djordje Atanackovic

https://doi.org/10.3324/haematol.2025.288856

Comments

2

Erratum

1

Erratum to: “Impact of hematopoietic cell transplantation and quizartinib in newly diagnosed patients with acute myeloid leukemia and FMS-like tyrosine kinase 3-internal tandem duplications in the QuANTUM-First trial” (3 Online Views)

Richard F. Schlenk, Pau Montesinos, Hee-Je Kim, Antonio Romero-Aguilar, Radovan Vrhovac, Elżbieta Patkowska, Pavel Žák, Po-Nan Wang, James Hanyok, Li Liu, Yasser Mostafa Kamel, Karima Imadalou, Arnaud Lesegretain, Jorge Cortes, Mikkael A. Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Alexander E. Perl, Mark J. Levis, Harry P. Erba

https://doi.org/10.3324/haematol.2025.289379