August, 2019
No. 104 (8)

Editorials

Perspective Articles

“Somatic” and “pathogenic” - is the classification strategy applicable in times of large-scale sequencing? (1680 Online Views)

Constance Baer, Wencke Walter, Stephan Hutter, Sven Twardziok, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach

https://doi.org/10.3324/haematol.2019.218917

Review Articles

Articles

Iron Metabolism & its Disorders

Rapid growth is a dominant predictor of hepcidin suppression and declining ferritin in Gambian infants (386 Online Views)

Andrew E. Armitage, Schadrac C. Agbla, Modupeh Betts, Ebrima A. Sise, Momodou W. Jallow, Ellen Sambou, Bakary Darboe, Archibald Worwui, George M. Weinstock, Martin Antonio, Sant-Rayn Pasricha, Andrew M. Prentice, Hal Drakesmith, Momodou K. Darboe, Brenda Anna Kwambana-Adams

https://doi.org/10.3324/haematol.2018.210146

Clinical and biological features in PIEZO1-hereditary xerocytosis and Gardos channelopathy: a retrospective series of 126 patients (1061 Online Views)

Véronique Picard, Corinne Guitton, Isabelle Thuret, Christian Rose, Laurence Bendelac, Kaldoun Ghazal, Patricia Aguilar-Martinez, Catherine Badens, Claire Barro, Claire Bénéteau, Claire Berger, Pascal Cathébras, Eric Deconinck, Jacques Delaunay, Jean-Marc Durand, Nadia Firah, Frédéric Galactéros, Bertrand Godeau, Xavier Jaïs, Jean-Pierre de Jaureguiberry, Camille Le Stradic, François Lifermann, Robert Maffre, Gilles Morin, Julien Perrin, Valérie Proulle, Marc Ruivard, Fabienne Toutain, Agnès Lahary, Loïc Garçon

https://doi.org/10.3324/haematol.2018.205328

Myelodysplastic Syndromes

A phase II study of guadecitabine in higher-risk myelodysplastic syndrome and low blast count acute myeloid leukemia after azacitidine failure (425 Online Views)

Marie Sébert, Aline Renneville, Cécile Bally, Pierre Peterlin, Odile Beyne-Rauzy, Laurence Legros, Marie-Pierre Gourin, Laurence Sanhes, Eric Wattel, Emmanuel Gyan, Sophie Park, Aspasia Stamatoullas, Anne Banos, Kamel Laribi, Simone Jueliger, Luke Bevan, Fatiha Chermat, Rosa Sapena, Olivier Nibourel, Cendrine Chaffaut, Sylvie Chevret, Claude Preudhomme, Lionel Adès, Pierre Fenaux

https://doi.org/10.3324/haematol.2018.207118

Myeloproliferative Neoplasms

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated (431 Online Views)

Nicolás Martínez-Calle, Marien Pascual, Raquel Ordoñez, Edurne San José Enériz, Marta Kulis, Estíbaliz Miranda, Elisabeth Guruceaga, Víctor Segura, María José Larráyoz, Beatriz Bellosillo, María José Calasanz, Carles Besses, José Rifón, José I. Martín-Subero, Xabier Agirre, Felipe Prosper

https://doi.org/10.3324/haematol.2018.204917

Chronic Myeloid Leukemia

Observational study of chronic myeloid leukemia Italian patients who discontinued tyrosine kinase inhibitors in clinical practice (593 Online Views)

Carmen Fava, Giovanna Rege-Cambrin, Irene Dogliotti, Marco Cerrano, Paola Berchialla, Matteo Dragani, Gianantonio Rosti, Fausto Castagnetti, Gabriele Gugliotta, Bruno Martino, Carlo Gambacorti-Passerini, Elisabetta Abruzzese, Chiara Elena, Patrizia Pregno, Antonella Gozzini, Isabella Capodanno, Micaela Bergamaschi, Monica Crugnola, Monica Bocchia, Sara Galimberti, Davide Rapezzi, Alessandra Iurlo, Daniele Cattaneo, Roberto Latagliata, Massimo Breccia, Michele Cedrone, Marco Santoro, Mario Annunziata, Luciano Levato, Fabio Stagno, Francesco Cavazzini, Nicola Sgherza, Valentina Giai, Luigia Luciano, Sabina Russo, Pellegrino Musto, Giovanni Caocci, Federica Sorà, Francesco Iuliano, Francesca Lunghi, Giorgina Specchia, Fabrizio Pane, Dario Ferrero, Michele Baccarani, Giuseppe Saglio

https://doi.org/10.3324/haematol.2018.205054

Acute Myeloid Leukemia

RUNX1 inhibits proliferation and induces apoptosis of t(8;21) leukemia cells via KLF4-mediated transactivation of P57 (676 Online Views)

Shuang Liu, Yanyan Xing, Wenting Lu, Shouyun Li, Zheng Tian, Haiyan Xing, Kejing Tang, Yingxi Xu, Qing Rao, Min Wang, Jianxiang Wang

https://doi.org/10.3324/haematol.2018.192773

Acute Lymphoblastic Leukemia

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms (482 Online Views)

Steven Goossens, Jueqiong Wang, Cedric S. Tremblay, Jelle De Medts, Sara T’Sas, Thao Nguyen, Jesslyn Saw, Katharina Haigh, David J. Curtis, Pieter Van Vlierberghe, Geert Berx, Tom Taghon, Jody J. Haigh

https://doi.org/10.3324/haematol.2018.207837

DNMT3A mutation is associated with increased age and adverse outcome in adult T-cell acute lymphoblastic leukemia (2414 Online Views)

Jonathan Bond, Aurore Touzart, Stéphane Leprêtre, Carlos Graux, Mario Bargetzi, Ludovic Lhermitte, Guillaume Hypolite, Thibaut Leguay, Yosr Hicheri, Gaëlle Guillerm, Karin Bilger, Véronique Lhéritier, Mathilde Hunault, Françoise Huguet, Yves Chalandon, Norbert Ifrah, Elizabeth Macintyre, Hervé Dombret, Vahid Asnafi, Nicolas Boissel

https://doi.org/10.3324/haematol.2018.197848

Non-Hodgkin Lymphoma

Human leukocyte antigen class II expression is a good prognostic factor in adult T-cell leukemia/lymphoma (539 Online Views)

Mai Takeuchi, Hiroaki Miyoshi, Naoko Asano, Noriaki Yoshida, Kyohei Yamada, Eriko Yanagida, Mayuko Moritsubo, Michiko Nakata, Takeshi Umeno, Takaharu Suzuki, Satoru Komaki, Hiroko Muta, Takuya Furuta, Masao Seto, Koichi Ohshima

https://doi.org/10.3324/haematol.2018.205567

The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models (695 Online Views)

Stuart W. Hicks, Chiara Tarantelli, Alan Wilhem, Eugenio Gaudio, Min Li, Alberto J. Arribas, Filippo Spriano, Roberta Bordone, Luciano Cascione, Katharine C. Lai, Qifeng Qiu, Monica Taborelli, Davide Rossi, Georg Stussi, Emanuele Zucca, Anastasios Stathis, Callum M. Sloss, Francesco Bertoni

https://doi.org/10.3324/haematol.2018.211011

Plasma Cell Disorders

Once-weekly versus twice-weekly carfilzomib in patients with newly diagnosed multiple myeloma: a pooled analysis of two phase I/II studies (661 Online Views)

Sara Bringhen, Roberto Mina, Maria Teresa Petrucci, Gianluca Gaidano, Stelvio Ballanti, Pellegrino Musto, Massimo Offidani, Stefano Spada, Giulia Benevolo, Elena Ponticelli, Piero Galieni, Michele Cavo, Tommaso Caravita Di Toritto, Francesco Di Raimondo, Vittorio Montefusco, Antonio Palumbo, Mario Boccadoro, Alessandra Larocca

https://doi.org/10.3324/haematol.2018.208272

Platelet Biology & its Disorders

Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice (480 Online Views)

Surasak Wichaiyo, Sian Lax, Samantha J. Montague, Zhi Li, Beata Grygielska, Jeremy A. Pike, Elizabeth J. Haining, Alexander Brill, Steve P. Watson, Julie Rayes

https://doi.org/10.3324/haematol.2018.208363

All-trans retinoic acid protects mesenchymal stem cells from immune thrombocytopenia by regulating the complement–interleukin-1β loop (456 Online Views)

Xiaolu Zhu, Yanan Wang, Qian Jiang, Hao Jiang, Jin Lu, Yazhe Wang, Yuan Kong, Yingjun Chang, Lanping Xu, Jun Peng, Ming Hou, Xiaojun Huang, Xiaohui Zhang

https://doi.org/10.3324/haematol.2018.204446

Hemostasis

Recurrent stroke: the role of thrombophilia in a large international pediatric stroke population (584 Online Views)

Gabrielle deVeber, Fenella Kirkham, Kelsey Shannon, Leonardo Brandão, Ronald Sträter, Gili Kenet, Hartmut Clausnizer, Mahendranath Moharir, Martina Kausch, Rand Askalan, Daune MacGregor, Monika Stoll, Antje Torge, Nomazulu Dlamini, Vijeja Ganesan, Mara Prengler, Jaspal Singh, Ulrike Nowak-Göttl

https://doi.org/10.3324/haematol.2018.211433

Stem Cell Transplantation

Fecal microbiota transplantation before or after allogeneic hematopoietic transplantation in patients with hematologic malignancies carrying multidrug-resistance bacteria (976 Online Views)

Giorgia Battipaglia, Florent Malard, Marie Therèse Rubio, Annalisa Ruggeri, Anne Claire Mamez, Eolia Brissot, Federica Giannotti, Remy Dulery, Anne Christine Joly, Minh Tam Baylatry, Marie Jeanne Kossmann, Jacques Tankovic, Laurent Beaugerie, Harry Sokol, Mohamad Mohty

https://doi.org/10.3324/haematol.2018.198549

Online Only Articles

Letters to the Editor

Diet and gender influence survival of transgenic Berkley sickle cell mice (312 Online Views)

Om B. Jahagirdar, Aditya M. Mittal, Waogwende L. Song-Naba, Ritu Jha, Stacy B. Kiven, Susan T. Thompson, John E Connett, Kalpna Gupta

https://doi.org/10.3324/haematol.2018.208322

Stem cell transplantation for congenital dyserythropoietic anemia: an analysis from the European Society for Blood and Marrow Transplantation (380 Online Views)

Maurizio Miano, Dirk-Jan Eikema, Mahmoud Aljurf, Pieter J. van’t Veer, Gülyüz Öztürk, Matthias Wölfl, Frans Smiers, Angsar Schulz, Gerard Socié, Kim Vettenranta, Cristina Diaz de Heredia, Marco Zecca, Johan Maertens, Montserrat Rovira, Jorge Sierra, Duygu Uckan-Cetinkaya, Elena Skorobogatova, Ali Bülent Antmen, Jean-Hugues Dalle, Miroslaw Markiewicz, Rose Marie Hamladji, Vassiliki Kitra-Roussou, Giorgio La Nasa, Gergely Kriván, Amal Al-Seiraihy, Stefano Giardino, Antonio Maria Risitano, Regis Peffault de Latour, Carlo Dufour

https://doi.org/10.3324/haematol.2018.206623

CD371 cell surface expression: a unique feature of DUX4-rearranged acute lymphoblastic leukemia (444 Online Views)

Dagmar Schinnerl, Ester Mejstrikova, Angela Schumich, Marketa Zaliova, Klaus Fortschegger, Karin Nebral, Andishe Attarbaschi, Karel Fiser, Maximilian O. Kauer, Niko Popitsch, Sabrina Haslinger, Andrea Inthal, Barbara Buldini, Giuseppe Basso, Jean-Pierre Bourquin, Giuseppe Gaipa, Monika Brüggemann, Tamar Feuerstein, Margarita Maurer-Granofszky, Renate Panzer-Grümayer, Jan Trka, Georg Mann, Oskar A. Haas, Ondrej Hrusak, Michael N. Dworzak, Sabine Strehl

https://doi.org/10.3324/haematol.2018.214353

Long-term follow up after third-party viral-specific cytotoxic lymphocytes for immunosuppression- and Epstein-Barr virus-associated lymphoproliferative disease (455 Online Views)

Sajida Kazi, Abhinav Mathur, Gwen Wilkie, Kirsty Cheal, Richard Battle, Neil McGowan, Neil Fraser, Emily Hargreaves, David Turner, John D.M. Campbell, Marc Turner, Mark A. Vickers

https://doi.org/10.3324/haematol.2018.207548

Post-transplant outcome of ovarian tissue cryopreserved after chemotherapy in hematologic malignancies (381 Online Views)

Catherine Poirot, Anne Fortin, Nathalie Dhédin, Pauline Brice, Gérard Socié, Jean-Marc Lacorte, Jean-Paul Akakpo, Catherine Genestie, Jean-Paul Vernant, Thierry Leblanc, Jean Gabarre, Alain Delmer, Yasmina Badachi, Véronique Drouineaud, Céline Chalas, Sophie Egels, Philippe Touraine, Marc Dommergues, Géraldine Lebègue, Jean-Philippe Wolf, Frédérique Capron, Gilles Lefebvre, Nicolas Boissel

https://doi.org/10.3324/haematol.2018.211094

Role of factor VIII-binding capacity of endogenous von Willebrand factor in the development of factor VIII inhibitors in patients with severe hemophilia A (343 Online Views)

Yohann Repessé, Catherine Costa, Roberta Palla, Elika Farrokhi Moshai, Annie Borel-Derlon, Roseline D’Oiron, Chantal Rothschild, Amal El-Beshlawy, Mohsen Elalfy, Vijay Ramanan, Peyman Eshghi, Johannes Oldenburg, Anna Pavlova, Frits R Rosendaal, Flora Peyvandi, Srinivas V. Kaveri, Sébastien Lacroix-Desmazes

https://doi.org/10.3324/haematol.2018.212001

Shared cell of origin in a patient with Erdheim-Chester disease and acute myeloid leukemia (372 Online Views)

Armin Ghobadi, Christopher A. Miller, Tiandao Li, Michelle O’Laughlin, Yi-Shan Lee, Mohga Ali, Peter Westervelt, John F. DiPersio, Lukas Wartman

https://doi.org/10.3324/haematol.2019.217794

Epstein-Barr virus-associated lymphoproliferative disease during imatinib mesylate treatment for chronic myeloid leukemia (302 Online Views)

Junko Yamaguchi, Takahiro Fujino, Reiko Isa, Daichi Nishiyama, Saeko Kuwahara-Ota, Yuka Kawaji, Taku Tsukamoto, Yoshiaki Chinen, Yuji Shimura, Tsutomu Kobayashi, Shigeo Horiike, Kei Kohno, Shigeo Nakamura, Junya Kuroda

https://doi.org/10.3324/haematol.2019.217141

Comment