July, 2019
No. 104 (7)

Editorials

Perspective Articles

Review Articles

Articles

Hematopoiesis

NIPBL: a new player in myeloid cell differentiation

Mara Mazzola, Gianluca Deflorian, Alex Pezzotta, Laura Ferrari, Grazia Fazio, Erica Bresciani, Claudia Saitta, Luca Ferrari, Monica Fumagalli, Matteo Parma, Federica Marasca, Beatrice Bodega, Paola Riva, Franco Cotelli, Andrea Biondi, Anna Marozzi, Gianni Cazzaniga, Anna Pistocchi

https://doi.org/10.3324/haematol.2018.200899

Red Cell Biology & Its Disorders

NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms

Naiara Santana-Codina, Sebastian Gableske, Maria Quiles del Rey, Beata Małachowska, Mark P. Jedrychowski, Douglas E. Biancur, Paul J. Schmidt, Mark D. Fleming, Wojciech Fendler, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias

https://doi.org/10.3324/haematol.2018.204123

Myelodysplastic Syndromes

Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide

Thorben Mährle, Nuray Akyüz, Pim Fuchs, Nicola Bonzanni, Donjete Simnica, Ulrich Germing, Anne Marie Asemissen, Johann Christoph Jann, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak, Mascha Binder

https://doi.org/10.3324/haematol.2018.208223

Acute Myeloid Leukemia

LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells

Rhys G. Morgan, Jenna Ridsdale, Megan Payne, Kate J. Heesom, Marieangela C. Wilson, Andrew Davidson, Alexander Greenhough, Sara Davies, Ann C. Williams, Allison Blair, Marian L. Waterman, Alex Tonks, Richard L. Darley

https://doi.org/10.3324/haematol.2018.202846

Loss of plasmacytoid dendritic cell differentiation is highly predictive for post-induction measurable residual disease and inferior outcomes in acute myeloid leukemia

Wenbin Xiao, Aaron D. Goldberg, Christopher A. Famulare, Sean M. Devlin, Nghia T. Nguyen, Sinnifer Sim, Charlene C. Kabel, Minal A. Patel, Erin M. McGovern, Akshar Patel, Jessica Schulman, Andrew J. Dunbar, Zachary D. Epstein-Peterson, Kamal N. Menghrajani, Bartlomiej M. Getta, Sheng F. Cai, Mark B. Geyer, Jacob L. Glass, Justin Taylor, Aaron D. Viny, Ross L. Levine, Yanming Zhang, Sergio A. Giralt, Virginia Klimek, Martin S. Tallman, Mikhail Roshal

https://doi.org/10.3324/haematol.2018.203018

Acute Lymphoblastic Leukemia

Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort

Marketa Zaliova, Jan Stuchly, Lucie Winkowska, Alena Musilova, Karel Fiser, Martina Slamova, Julia Starkova, Martina Vaskova, Ondrej Hrusak, Lucie Sramkova, Jan Stary, Jan Zuna, Jan Trka

https://doi.org/10.3324/haematol.2018.204974

ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity

Marketa Zaliova, Eliska Potuckova, Lenka Hovorkova, Alena Musilova, Lucie Winkowska, Karel Fiser, Jan Stuchly, Ester Mejstrikova, Julia Starkova, Jan Zuna, Jan Stary, Jan Trka

https://doi.org/10.3324/haematol.2018.204487

Non-Hodgkin Lymphoma

Blockade of crizotinib-induced BCL2 elevation in ALK-positive anaplastic large cell lymphoma triggers autophagy associated with cell death

Avedis Torossian, Nicolas Broin, Julie Frentzel, Camille Daugrois, Sarah Gandarillas, Talal Al Saati, Laurence Lamant, Pierre Brousset, Sylvie Giuriato, Estelle Espinos

https://doi.org/10.3324/haematol.2017.181966

Plasma Cell Disorders

Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients

John R. Jones, Niels Weinhold, Cody Ashby, Brian A. Walker, Chris Wardell, Charlotte Pawlyn, Leo Rasche, Lorenzo Melchor, David A. Cairns, Walter M. Gregory, David Johnson, Dil B. Begum, Sidra Ellis, Amy L. Sherborne, Gordon Cook, Martin F. Kaiser, Mark T. Drayson, Roger G. Owen, Graham H. Jackson, Faith E. Davies, Mel Greaves, Gareth J. Morgan

https://doi.org/10.3324/haematol.2018.202200

Performance analysis of AL amyloidosis cardiac biomarker staging systems with special focus on renal failure and atrial arrhythmia

Tobias Dittrich, Axel Benner, Christoph Kimmich, Fabian aus dem Siepen, Kaya Veelken, Arnt V. Kristen, Tilmann Bochtler, Hugo A. Katus, Carsten Müller-Tidow, Ute Hegenbart, Stefan O. Schönland

https://doi.org/10.3324/haematol.2018.205336

Platelet Biology & its Disorders

Molecular mechanisms of bleeding disorderassociated GFI1BQ287* mutation and its affected pathways in megakaryocytes and platelets

Rinske van Oorschot, Marten Hansen, Johanna M. Koornneef, Anna E. Marneth, Saskia M. Bergevoet, Maaike G.J.M. van Bergen, Floris P.J. van Alphen, Carmen van der Zwaan, Joost H.A. Martens, Michiel Vermeulen, Pascal W.T.C. Jansen, Marijke P.A. Baltissen, Britta A.P. Laros-van Gorkom, Hans Janssen, Joop H. Jansen, Marieke von Lindern, Alexander B. Meijer, Emile van den Akker, Bert A. van der Reijden

https://doi.org/10.3324/haematol.2018.194555

Mechanisms of thrombocytopenia in platelet-type von Willebrand disease

Loredana Bury, Alessandro Malara, Stefania Momi, Eleonora Petito, Alessandra Balduini, Paolo Gresele

https://doi.org/10.3324/haematol.2018.200378

Hemostasis

Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors

Ankit S. Macwan, Niklas Boknäs, Maria P. Ntzouni, Sofia Ramström, Jonathan M. Gibbins, Lars Faxälv, Tomas L. Lindahl

https://doi.org/10.3324/haematol.2018.205815

Coagulation & Its Disorders

Six months versus two years of oral anticoagulation after a first episode of unprovoked deep-vein thrombosis. The PADIS-DVT randomized clinical trial

Francis Couturaud, Gilles Pernod, Emilie Presles, Elisabeth Duhamel, Patrick Jego, Karine Provost, Brigitte Pan-Petesch, Claire Bal dit Sollier, Cécile Tromeur, Clément Hoffmann, Luc Bressollette, Philippe Lorillon, Philippe Girard, Emmanuelle Le Moigne, Aurelia Le Hir, Marie Guégan, Silvy Laporte, Patrick Mismetti, Karine Lacut, Jean-Luc Bosson, Laurent Bertoletti, Oliver Sanchez, Guy Meyer, Christophe Leroyer, Dominique Mottier, for the “PADIS-DVT” investigators

https://doi.org/10.3324/haematol.2018.210971

Online Only Articles

Letters to the Editor

Co-inheritance of a-thalassemia dramatically decreases the risk of acute splenic sequestration in a large cohort of newborns with hemoglobin SC

Paulo V. Rezende, André R. Belisário, Érica L. Oliveira, Jéssica A. Almeida, Larissa M. M. Oliveira, Maristela B.S.R. Muniz, Marcos B. Viana

https://doi.org/10.3324/haematol.2018.209221

SDF1α-induced chemotaxis of JAK2-V617F-positive cells is dependent on Bruton tyrosine kinase and its downstream targets PI3K/AKT, PLCγ1 and RhoA

Subbaiah Chary Nimmagadda, Stephanie Frey, Peter Müller, Denise Wolleschak, Sönke Weinert, Ulrich Keller, Bärbel Edelmann, Thomas Fischer

https://doi.org/10.3324/haematol.2018.201921

Persistence with generic imatinib for chronic myeloid leukemia: a matched cohort study

Adi J. Klil-Drori, Hui Yin, Laurent Azoulay, Michaël Harnois, Michel-Olivier Gratton, Lambert Busque, Sarit E. Assouline

https://doi.org/10.3324/haematol.2018.211235

miR-101 suppresses the development of MLL-rearranged acute myeloid leukemia

Estrella Gonzales-Aloy, Patrick Connerty, Basit Salik, Bing Liu, Andrew J. Woo, Michelle Haber, Murray D. Norris, Jianlong Wang, Jenny Y. Wang

https://doi.org/10.3324/haematol.2018.209437

Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia

Laurence C. Cheung, Mark N. Cruickshank, Anastasia M. Hughes, Sajla Singh, Grace-Alyssa Chua, Jette Ford, Emanuela Ferrari, Joyce Oommen, Sébastien Malinge, Richard B. Lock, Ursula R. Kees, Rishi S. Kotecha

https://doi.org/10.3324/haematol.2018.192906

Allogeneic transplantation in high-risk chronic lymphocytic leukemia: a single-center, intent-to-treat analysis

Almuth Hoffmann, Sascha Dietrich, Susanne Hain, Michael Rieger, Ute Hegenbart, Leopold Sellner, Anthony D. Ho, Carsten Müller-Tidow, Peter Dreger

https://doi.org/10.3324/haematol.2018.209486

The Bruton tyrosine kinase inhibitor zanubrutinib (BGB-3111) demonstrated synergies with other anti-lymphoma targeted agents

Chiara Tarantelli, Lu Zhang, Elisabetta Curti, Eugenio Gaudio, Filippo Spriano, Valdemar Priebe, Luciano Cascione, Alberto J. Arribas, Emanuele Zucca, Davide Rossi, Anastasios Stathis, Francesco Bertoni

https://doi.org/10.3324/haematol.2018.214759

PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma

Barbara Muz, Maurizio Buggio, Feda Azab, Pilar de la Puente, Mark Fiala, Mahesh V. Padval, David T. Weaver, Jonathan A. Pachter, Ravi Vij, Abdel Kareem Azab

https://doi.org/10.3324/haematol.2018.194688

A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation

Jed Paul, Hideki Nakasone, Bita Sahaf, Fang Wu, Kathy Wang, Vincent Ho, Juan Wu, Haesook Kim, Bruce Blazar, Jerome Ritz, Alan Howard, Corey Cutler, David Miklos

https://doi.org/10.3324/haematol.2018.199646

Case Report

A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia

Jesse J.C. Cheah, Anna L. Brown, Andreas W. Schreiber, Jinghua Feng, Milena Babic, Sarah Moore, Chun-Chun Young, Miriam Fine, Kerry Phillips, Michael Guandalini, Peter Wilson, Nicola Poplawski, Christopher N. Hahn, Hamish S. Scott

https://doi.org/10.3324/haematol.2018.207316

Multisystem autoimmune disease caused by increased STAT3 phosphorylation and dysregulated gene expression

Francesca Todaro, Nicola Tamassia, Marinella Pinelli, Daniele Moratto, Laura Dotta, Alessia Grassi, Filippo Consonni, Mauro Giacomelli, Paolo Lionetti, Elisa Gardiman, Marco A. Cassatella, Eleonora Gambineri, Roberto Berni Canani, Raffaele Badolato

https://doi.org/10.3324/haematol.2018.202374

Branched clonal evolution: nodal follicular lymphoma and primary diffuse large B-cell lymphoma of the central nervous system

Gilberto I. Barranco, Sara Fernández, Raquel Oña, Julia González-Rincón, Angel Martínez-Ramírez, Ana Teijo, Francisca I. Camacho, Fernando J. Pinedo, Margarita Sánchez-Beato, Lucia Pedrosa, Adolfo de la Fuente, Mónica Estévez, Rebeca Iglesias, Carlos Montalbán, Juan F. García

https://doi.org/10.3324/haematol.2018.214981

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