September, 2019
No. 104 (9)

Editorials

Perspective Articles

Review Articles

Articles

Hematopoiesis

MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation

Laura Crisafulli, Sharon Muggeo, Paolo Uva, Yulei Wang, Masayuki Iwasaki, Silvia Locatelli, Achille Anselmo, Federico S. Colombo, Carmelo Carlo-Stella, Michael L. Cleary, Anna Villa, Bernhard Gentner, Francesca Ficara

https://doi.org/10.3324/haematol.2018.198499

Iron Metabolism & Its Disorders

New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia

Jing Liu, Wei Liu, Yin Liu, Yang Miao, Yifan Guo, Haoyang Song, Fudi Wang, Hongyu Zhou, Tomas Ganz, Bing Yan, Sijin Liu

https://doi.org/10.3324/haematol.2018.209874

Myeloproliferative Neoplasms

Long-term outcome after allogeneic hematopoietic cell transplantation for myelofibrosis

Marie Robin, Liesbeth C. de Wreede, Christine Wolschke, Johannes Schetelig, Diderik-Jan Eikema, Maria Teresa Van Lint, Nina Simone Knelange, Dietrich Beelen, Arne Brecht, Dietger Niederwieser, Antonin Vitek, Wolfgang Bethge, Renate Arnold, Jürgen Finke, Liisa Volin, Ibrahim Yakoub-Agha, Arnon Nagler, Xavier Poiré, Hermann Einsele, Patrice Chevallier, Ernst Holler, Per Ljungman, Stephen Robinson, Alekxandar Radujkovic, Donal McLornan, Yves Chalandon, Nicolaus Kröger

https://doi.org/10.3324/haematol.2018.205211

Chronic Myeloid Leukemia

De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways

Vera Magistroni, Mario Mauri, Deborah D’Aliberti, Caterina Mezzatesta, Ilaria Crespiatico, Miriam Nava, Diletta Fontana, Nitesh Sharma, Wendy Parker, Andreas Schreiber, David Yeung, Alessandra Pirola, Sara Readelli, Luca Massimino, Paul Wang, Praveen Khandelwal, Stefania Citterio, Michela Viltadi, Silvia Bombelli, Roberta Rigolio, Roberto Perego, Jacqueline Boultwood, Alessandro Morotti, Giuseppe Saglio, Dong-Wook Kim, Susan Branford, Carlo Gambacorti-Passerini, Rocco Piazza

https://doi.org/10.3324/haematol.2017.179937

Acute Myeloid Leukemia

Acute Lymphoblastic Leukemia

Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM

Elizabeth C. Matheson, Huw Thomas, Marian Case, Helen Blair, Rosanna K. Jackson, Dino Masic, Gareth Veal, Chris Halsey, David R. Newell, Josef Vormoor, Julie A.E. Irving

https://doi.org/10.3324/haematol.2017.185975

Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study

Carmelo Rizzari, Claudia Lanvers-Kaminsky, Maria Grazia Valsecchi, Andrea Ballerini, Cristina Matteo, Joachim Gerss, Gudrun Wuerthwein, Daniela Silvestri, Antonella Colombini, Valentino Conter, Andrea Biondi, Martin Schrappe, Anja Moericke, Martin Zimmermann, Arend von Stackelberg, Christin Linderkamp, Michael C. Frühwald, Sabine Legien, Andishe Attarbaschi, Bettina Reismüller, David Kasper, Petr Smisek, Jan Stary, Luciana Vinti, Elena Barisone, Rosanna Parasole, Concetta Micalizzi, Massimo Zucchetti, Joachim Boos

https://doi.org/10.3324/haematol.2018.206433

Non-Hodgkin Lymphoma

Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma

Blanca Gonzalez-Farre, Joan Enric Ramis-Zaldivar, Julia Salmeron-Villalobos, Olga Balagué, Verónica Celis, Jaime Verdu-Amoros, Ferran Nadeu, Constantino Sábado, Antonio Ferrández, Marta Garrido, Federico García-Bragado, María Dolores de la Maya, José Manuel Vagace, Carlos Manuel Panizo, Itziar Astigarraga, Mara Andrés, Elaine S. Jaffe, Elias Campo, Itziar Salaverria

https://doi.org/10.3324/haematol.2018.207928

Chronic Lymphocytic Leukemia

Cell Therapy & Immunotherapy

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

Simone C. Oostindie, Hilma J. van der Horst, Margaret A. Lindorfer, Erika M. Cook, Jillian C. Tupitza, Clive S. Zent, Richard Burack, Karl R. VanDerMeid, Kristin Strumane, Martine E. D. Chamuleau, Tuna Mutis, Rob N. de Jong, Janine Schuurman, Esther C. W. Breij, Frank J. Beurskens, Paul W. H. I. Parren, Ronald P. Taylor

https://doi.org/10.3324/haematol.2018.207266

Platelet Biology & its Disorders

CD45 expression discriminates waves of embryonic megakaryocytes in the mouse

Isabel Cortegano, Natalia Serrano, Carolina Ruiz, Mercedes Rodríguez, Carmen Prado, Mario Alía, Andrés Hidalgo, Eva Cano, Belén de Andrés, María-Luisa Gaspar

https://doi.org/10.3324/haematol.2018.192559

Fatal dysfunction and disintegration of thrombin-stimulated platelets

Oleg V. Kim, Tatiana A. Nevzorova, Elmira R. Mordakhanova, Anastasia A. Ponomareva, Izabella A. Andrianova, Giang Le Minh, Amina G. Daminova, Alina D. Peshkova, Mark S. Alber, Olga Vagin, Rustem I. Litvinov, John W. Weisel

https://doi.org/10.3324/haematol.2018.202309


Hemostasis

Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells

Peter J. Noy, Rebecca L. Gavin, Dario Colombo, Elizabeth J. Haining, Jasmeet S. Reyat, Holly Payne, Ina Thielmann, Adam B. Lokman, Georgiana Neag, Jing Yang, Tammy Lloyd, Neale Harrison, Victoria L. Heath, Chris Gardiner, Katharine M. Whitworth, Joseph Robinson, Chek Z. Koo, Alessandro Di Maio, Paul Harrison, Steven P. Lee, Francesco Michelangeli, Neena Kalia, G. Ed Rainger, Bernhard Nieswandt, Alexander Brill, Steve P. Watson, Michael G. Tomlinson

https://doi.org/10.3324/haematol.2018.194241

Online Only Articles

Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life

Rima S. Zahr, Evadnie Rampersaud, Guolian Kang, Mitchell J. Weiss, Gang Wu, Robert L. Davis, Jane S. Hankins, Jeremie H. Estepp, Jeffrey Lebensburger

https://doi.org/10.3324/haematol.2018.212779

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

Daniel A. Pollyea, Chelsea Harris, Jennifer L. Rabe, Brenna R. Hedin, Lesly De Arras, Sigrid Katz, Emily Wheeler, Rafael Bejar, Matthew J. Walter, Craig T. Jordan, Eric M. Pietras, Scott Alper

https://doi.org/10.3324/haematol.2018.214155

Adult patients with de novo acute myeloid leukemia show a functional deregulation of redox balance at diagnosis which is correlated with molecular subtypes and overall survival

Julie Mondet, Caroline Lo Presti, Catherine Garrel, Kristina Skaare, Clara Mariette, Sylvain Carras, Sophie Park, Martin Carré, Claude-Eric Bulabois, Lysiane Molina, Rémy Gressin, Anne Thiebaut, Stéphane Courby, Nuria Socoro-Yuste, Patrice Faure, Anne Mc Leer-Florin, Jean-Yves Cahn, Pascal Mossuz

https://doi.org/10.3324/haematol.2018.206821

Sorafenib improves survival of FLT3-mutated acute myeloid leukemia in relapse after allogeneic stem cell transplantation: a report of the EBMT Acute Leukemia Working Party

Ali Bazarbachi, Myriam Labopin, Giorgia Battipaglia, Azedine Djabali, Jakob Passweg, Gerard Socié, Edouard Forcade, Didier Blaise, Patrice Chevallier, Corentin Orvain, Jan J. Cornelissen, William Arcese, Sylvain Chantepie, Khowla Hashaishi, Jean El Cheikh, Michael Medinger, Jordi Esteve, Arnon Nagler, Mohamad Mohty

https://doi.org/10.3324/haematol.2018.211615

TP53, ETV6 and RUNX1 germline variants in a case series of patients developing secondary neoplasms after treatment for childhood acute lymphoblastic leukemia

Stefanie V. Junk, Norman Klein, Sabine Schreek, Martin Zimmermann, Anja Möricke, Kirsten Bleckmann, Julia Alten, Elif Dagdan, Gunnar Cario, Christian P. Kratz, Martin Schrappe, Martin Stanulla

https://doi.org/10.3324/haematol.2018.205849

A high definition picture of key genes and pathways mutated in pediatric follicular lymphoma

Federica Lovisa, Andrea Binatti, Alessandro Coppe, Simona Primerano, Elisa Carraro, Marta Pillon, Marco Pizzi, Vincenza Guzzardo, Salvatore Buffardi, Fulvio Porta, Piero Farruggia, Raffaela De Santis, Pietro Bulian, Giuseppe Basso, Elena Lazzari, Emanuele S.G. d’Amore, Stefania Bortoluzzi, Lara Mussolin

https://doi.org/10.3324/haematol.2018.211631

A B-cell receptor-related gene signature predicts response to ibrutinib treatment in mantle cell lymphoma cell lines

Tiziana D’Agaro, Antonella Zucchetto, Filippo Vit, Tamara Bittolo, Erika Tissino, Francesca Maria Rossi, Massimo Degan, Francesco Zaja, Pietro Bulian, Michele Dal Bo, Simone Ferrero, Marco Ladetto, Alberto Zamò, Valter Gattei, Riccardo Bomben

https://doi.org/10.3324/haematol.2018.212811

A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis

Lenka Besse, Andrej Besse, Max Mendez-Lopez, Katerina Vasickova, Miroslava Sedlackova, Petr Vanhara, Marianne Kraus, Jürgen Bader, Renan B. Ferreira, Ronald K. Castellano, Brian K. Law, Christoph Driessen

https://doi.org/10.3324/haematol.2018.207704

Quantitative dynamic 18F-fluorodeoxyglucose positron emission tomography/computed tomography before autologous stem cell transplantation predicts survival in multiple myeloma

Christos Sachpekidis, Maximilian Merz, Annette Kopp-Schneider, Anna Jauch, Marc-Steffen Raab, Sandra Sauer, Jens Hillengass, Hartmut Goldschmidt, Antonia Dimitrakopoulou-Strauss

https://doi.org/10.3324/haematol.2018.213041

The diagnostic performance of renal function-adjusted D-dimer testing in individuals suspected of having venous thromboembolism

Vincent ten Cate, Markus Nagler, Marina Panova-Noeva, Lisa Eggebrecht, Natalie Arnold, Heidrun Lamparter, M Iris Hermanns, Hugo ten Cate, Martin H. Prins, Christine Espinola-Klein, Thomas Münzel, Karl J. Lackner, Philipp S. Wild, Jürgen H. Prochaska

https://doi.org/10.3324/haematol.2018.213322

Case Report

Venetoclax resistance and acquired BCL2 mutations in chronic lymphocytic leukemia

Eugen Tausch, William Close, Anna Dolnik, Johannes Bloehdorn, Brenda Chyla, Lars Bullinger, Hartmut Döhner, Daniel Mertens, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2019.222588