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Role of factor VIII-binding capacity of endogenous von Willebrand factor in the development of factor VIII inhibitors in patients with severe hemophilia A

CHU de Caen, Hematology Laboratory, Caen, France;INSERM, U1237, GIP Cyceron, Caen, France;Normandie Université, UNI-CAEN, UFR Santé, Caen, France
Service de Génétique et Biologie Moléculaires, APHP, Groupe Hospitalier Cochin Broca, Hôtel-Dieu, Site Cochin, Paris, France
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France
CHU de Caen, Hematology Laboratory, Caen, France;INSERM, U1237, GIP Cyceron, Caen, France;Normandie Université, UNI-CAEN, UFR Santé, Caen, France
Centres de Traitement de l’Hémophilie, APHP, Le Kremlin-Bicêtre, France
Centres de Traitement de l’Hémophilie, APHP, Hôpital Necker, Paris, France
Pediatric Hematology Department, Cairo University Pediatric Hospital, Cairo, Egypt
Faculty of Medicine, Ain Shams Center, University - Department of Pediatrics, Cairo, Egypt
Jehangir Clinical Development Center, Department of Hematology, Jehangir Hospital Premises, Pune, India
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Institute of Experimental Hematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
Institute of Experimental Hematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milano, Italy
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France
Vol. 104 No. 8 (2019): August, 2019 https://doi.org/10.3324/haematol.2018.212001