CURRENT ISSUE
May, 2026
No. 111 (5)

Landmark papers in Hematology

1

Editorials

7

Review Series

6
Clonal hematopoiesis

Articles

14
Acute Myeloid Leukemia

Menin inhibitor DS-1594b drives differentiation and induces synergistic lethality in combination with venetoclax in acute myeloid leukemia cells with rearranged mixed-lineage leukemia and mutated nucleophosmin-1 (1238 Online Views)

Valerio Ciaurro, Vassilena Sharlandjieva, Anna Skwarska, Catherine Chahrour, Natalia Baran, Zhihong Zeng, Cassandra Ramage, Naval Daver, Bing Z. Carter, Sovira Chaundhry, Palaniraja Thandapani, Maria Paola Martelli, Thomas A. Milne, Marina Konopleva

https://doi.org/10.3324/haematol.2024.286833

IDH2 mutation is associated with favorable outcome among older adults with newly diagnosed acute myeloid leukemia treated with hypomethylating agent-based therapy (1137 Online Views)

Fieke W. Hoff, Ying Huang, Rina Li Welkie, Ronan T. Swords, Elie Traer, Eytan M. Stein, Tara L. Lin, Maria R. Baer, Vu H. Duong, William G. Blum, Martha L. Arellano, Wendy Stock, Olatoyosi Odenike, Joshua F. Zeidner, Rebecca L. Olin, Catherine C. Smith, Gary J. Schiller, Emily K. Curran, Shivani V. Handa, Nyla A. Heerema, Timothy Chen, Molly Martycz, Mona Stefanos, Sonja G. Marcus, Leonard Rosenberg, Brian J. Druker, Ross L. Levine, Amy Burd, Ashley O. Yocum, Uma M. Borate, Alice S. Mims, John C. Byrd, Yazan F. Madanat

https://doi.org/10.3324/haematol.2025.288743
Cell Therapy & Immunotherapy

Lipid dysregulation after hematopoietic stem cell transplant (626 Online Views)

Jane Koo, Lucille Langenberg, Xueheng Zhao, Kenneth R. Setchell, Kelly E. Lake, Nathan Luebbering, Ellen Walter, Adam Lane, Kasiani C. Myers, Damien Reynaud, Anthony Sabulski, Ashley Teusink-Cross, Sonata Jodele, Stella M. Davies

https://doi.org/10.3324/haematol.2025.288933
Hematopoiesis

Loss of endothelial miR-126 drives age-related decline in hematopoiesis (703 Online Views)

Dandan Zhao, Le Xuan Truong Nguyen, Xubo Gong, Fang Chen, Xiaoli Zhao, Min-Hsuan Chen, Guido Marcucci, Bin Zhang

https://doi.org/10.3324/haematol.2025.288736
Hematopoietic Cell Transplantation

Age-related differences in donor selection priorities for allogeneic hematopoietic transplantation (1156 Online Views)

Koji Kawamura, Junya Kanda, Sachiko Seo, Fumihiko Kimura, Masahiro Hirayama, Naoyuki Uchida, Noriko Doki, Wataru Takeda, Tetsuya Nishida, Yuta Katayama, Masatsugu Tanaka, Masashi Sawa, Satoshi Yoshihara, Tetsuya Eto, Toshiro Kawakita, Hirohisa Nakamae, Shuichi Ota, Fumihiko Ishimaru, Takahiro Fukuda, Yoshiko Atsuta, Yoshinobu Kanda

https://doi.org/10.3324/haematol.2025.288004
Histiocytic Disorder

Neurodegenerative Langerhans cell histiocytosis: long-term follow-up of 63 patients from the Italian Registry (703 Online Views)

Irene Trambusti, Francesco Pegoraro, Maria Luisa Coniglio, Stefania Gaspari, Stefano Chiaravalli, Paola Corti, Carmen De Fusco, Antonino Trizzino, Antonio Verrico, Veronica Barat, Monica Cellini, Alessandra Todesco, Michele Tanturli, Katiuscia Romano, Aurora Chinnici, Linda Beneforti, Marzia Mortilla, Anna Perrone, Annalisa Tondo, Renzo Guerrini, Carmen Barba, Elena Sieni

https://doi.org/10.3324/haematol.2025.288143
Myelodysplastic Syndromes

Decitabine plus all-trans retinoic acid versus decitabine monotherapy for myelodysplastic syndromes with excess blasts: a multicenter, randomized controlled trial (1011 Online Views)

Xinping Zhou, Yanjuan Lin, Yan Gao, Zheng Ge, Li Huang, Jin Zhang, Hai Cheng, Guifang Ouyang, Fanjun Meng, Yulu Tian, Yuemin Kuang, Fengping Zhou, Lixia Sheng, Weimei Jin, Gaixiang Xu, Liya Ma, Li Ye, Chen Mei, Jian Li, Jie Jin, Hongyan Tong

https://doi.org/10.3324/haematol.2025.288526
Non-Hodgkin Lymphoma

Marked survival gains in patients ≤ 65 years with advanced-stage mantle cell lymphoma: a pooled analysis of six randomized phase III trials, 1996-2020 (1067 Online Views)

Linmiao Jiang, Marco Ladetto, Olivier Hermine, Johanna C. Kluin-Nelemans, Jan Walewski, Jeanette Doorduijn, Vibeke Vergote, Eva Giné, Mats Jerkeman, Martin Hutchings, Marek Trneny, Ulrich Mey, Jon Riise, Ofer Shpilberg, Maria Gomes da Silva, Vincent Ribrag, Christian Schmidt, Wolfram Klapper, Michael Unterhalt, Martin Dreyling, Eva Hoster

https://doi.org/10.3324/haematol.2025.288929

Distinct interleukin-6 production in IPL and TAFRO subtypes of idiopathic multicentric Castleman disease (2045 Online Views)

Asami Nishikori, Midori Filiz Nishimura, Yoshito Nishimura, Rio Yamada, Tomoka Haratake, Daisuke Ennishi, Ryota Chijimatsu, Toshihiro Ito, Tomohiro Koga, Sayaka Ochi, Yuri Kawahara, Himawari Ueta, Yudai Takeda, Michael V. Gonzalez, David C. Fajgenbaum, Frits van Rhee, Shuji Momose, Yasuharu Sato

https://doi.org/10.3324/haematol.2025.288147
Platelet Biology & its Disorders

Ethnicity affects relapse-free survival in immunemediated thrombotic thrombocytopenic purpura (688 Online Views)

Júlia Weisinger, Florian Blanchard, Benoit Suzon, Christophe Deligny, Jehane Fadlallah, François Provôt, Pascale Poullin, Manon Marie, David Ribes, Gabriel Choukroun, Yahsou Delmas, Elie Azoulay, Ygal Benhamou, Maximilien Grall, Jean-Michel Halimi, Moglie Le Quintrec, Aude Servais, Thomas Papo, Camille Lepart, Claire Cartery, Valérie Chatelet, Jean-Francois Augusto, Simon Ville, Pierre Perez, Loïc Lièvre, Mathieu Legendre, Anne Rumpler, Alexandre Hertig, Virginie Rieu, Arnaud Jaccard, Patricia Zunic, Laurent Gilardin, Nihal Martis, Sara Rovira Puig, Rutuja Gupte, Maria del Mar Tolos Garcia, Margot Dierickx, Daniela Greco, Timon Albrecht, Andreea-Adela Icleanu, Raïda Bouzid, Bérangère Joly, Agnès Veyradier, Adrien Picod, Paul Coppo

https://doi.org/10.3324/haematol.2025.288789

CSF1R modulates megakaryopoiesis by targeting RUNX1 in immune thrombocytopenia (956 Online Views)

Haohao Han, Meng Zhou, Jiaqian Qi, Xiaofei Song, Xueqian Li, Ziyan Zhang, Tingting Pan, Xiaoyan Xu, Mengting Guo, Depei Wu, Yue Han

https://doi.org/10.3324/haematol.2025.288511
Red Cell Biology & its Disorders

Splenic erythrophagocytosis is regulated by ALX/FPR2 signaling (1428 Online Views)

Haley Asplund, Hector H. Dreyer, Jing-Juan Zheng, Richa Singhal, Jason L. Hellmann, Brian E. Sansbury

https://doi.org/10.3324/haematol.2025.288007

Letters to the Editor

17

Carbon footprint of direct oral anticoagulants in atrial fibrillation and venous thromboembolism (922 Online Views)

Laurence Chery, Zahra Hassani, Lise Durand, Dorothee Boisseau, Victorien Monguillon, David Grimaldi, Sebastien Taillemite, Benjamin de Sainte Marie, Nicolas Gendron

https://doi.org/10.3324/haematol.2025.300204

Cell-free BRAFV600E levels predict progression-free survival in children with Langerhans cell histiocytosis treated with dabrafenib and maintenance chemotherapy (670 Online Views)

Lei Cui, Dong Wang, Yun-Ze Zhao, Jia-Feng Yao, Chan-Juan Wang, Zi-Jing Zhao, Wei-Jing Li, Qing Zhang, Hong-Yun Lian, Hong-Hao Ma, Jian Ge, Zi-Shi Fang, Wen-Qian Wang, Jia-Jia Dong, Tian-You Wang, Zhi-Gang Li, Rui Zhang

https://doi.org/10.3324/haematol.2025.287578

Rituximab, dexamethasone, etoposide, ifosfamide and carboplatin (R-DeVIC) in relapsed or refractory central nervous system lymphoma: a retrospective multicentre clinical study (855 Online Views)

Kudret Kama, Hannes Treiber, Alexandra Kutilina, Stefan Trefz, Sophie Wollnitza, Evgenii Shumilov, Juergen Finke, Georg Lenz, Gerald Wulf, Lisa Kristina Isbell, Aslihan Aksoy, Antje Jensch, Gerald Illerhaus, Julia Wendler, Elisabeth Schorb

https://doi.org/10.3324/haematol.2025.287982

Integrative clinical and molecular characterization of an acute promyelocytic leukemia-like subgroup with high early death risk in newly diagnosed acute myeloid leukemia: a multicenter study (728 Online Views)

Mingkai Shu, Wenjing Ding, Linlin Wang, Zheng Wang, Lijun Wang, Mingqing Zhu, Dandan Liu, Hongjie Shen, Yun Wang, Xueqing Dou, Xiao Ma, Yang Zhang, Yang Xu, Ying Wang, Shengli Xue, Jianhong Fu, Huiying Qiu, Xiaowen Tang, Yue Han, Jinyan Huang, Depei Wu, Haiping Dai, Lijun Wen, Suning Chen

https://doi.org/10.3324/haematol.2025.288377

Loss of nuclear myosin 1 causes hemostatic defects and immune dysregulation (612 Online Views)

Tomas Venit, Samira Khalaji, Valentina Fambri, Wael Abdrobou, Mei El Gindi, Rahul Shrestha, Pavel Hozak, Youssef Idaghdour, Jeremy C.M. Teo, Piergiorgio Percipalle

https://doi.org/10.3324/haematol.2025.288392

Single-cell profiling of CD19-directed CAR T-cell phenotypes and immune system dynamics in pediatric B-cell acute lymphoblastic leukemia (1178 Online Views)

Aleksandra Oszer, Bartlomiej Pawlik, Natalia Cwilichowska-Puslecka, Pawel Marschollek, Monika Richert-Przygonska, Monika Mielcarek-Siedziuk, Jeremy C. Crawford, Maciej Mazurek, Abhishek Koladiya, Krzysztof Kałwak, Jan Styczynski, Szymon Janczar, Marcin Poreba, M Paulina Velasquez, Kara L. Davis, Wojciech Mlynarski

https://doi.org/10.3324/haematol.2025.288397

Altered glycosylation profile of anti-HPA-1a-specific antibodies: insights from a prospective fetal and neonatal alloimmune thrombocytopenia cohort (568 Online Views)

Janita J. Oosterhoff, Arthur E.H. Bentlage, David Falck, Wenjun Wang, Jan Nouta, Manfred Wuhrer, Steinar Gijze, Thijs de Vos, Dian Winkelhorst, Ellen C. van der Schoot, Gestur Vidarsson

https://doi.org/10.3324/haematol.2025.288701

Severe allergic and anaphylactic transfusion reactions in consecutive recipients from the same donor (601 Online Views)

Patrick Terrence Brooks, Christina Mikkelsen, Ewa Anna Bartko, Vaishnavi Ravikumar, Christoffer Egeberg Hother, Lia Minculescu, Hanne Vibeke, Sisse Rye Ostrowski, Morten Bagge Hansen, Lars K Poulsen, Lars H Blom, Lene H Garvey, Morten Hanefeld Dziegiel

https://doi.org/10.3324/haematol.2025.288783

Genetic alterations of SENP6 in multiple myeloma disrupt genome and proteome stability, sensitizing to proteasome inhibition (741 Online Views)

Frederik Herzberg, Michael Korenkov, Konstandina Isaakidis, Chuanbing Zang, Matthias Wirth, Stefan Müller, Ulrich Keller, Uta M. Demel

https://doi.org/10.3324/haematol.2025.288863

Allopurinol increases DNA-thioguanine nucleotides during maintenance therapy in pediatric acute lymphoblastic leukemia (586 Online Views)

Jonatan Källström, Riitta Niinimäki, Johan Fredlund, Hartmut Vogt, Laura S. Korhonen, Anders Castor, Kjeld Schmiegelow, Maria Thastrup, Torben Ek

https://doi.org/10.3324/haematol.2025.288872

Comparative effectiveness of immunotherapy alone or with chemotherapy as first-line treatment for marginal zone lymphoma (801 Online Views)

Adam J. Olszewski, Thomas A. Ollila, Dai Chihara, Geoffrey Shouse, Natalie Grover, Reem Karmali, Pallawi Torka, Colin Thomas, Praveen Ramakrishnan Geethakumari, Stefan K. Barta, Nancy L. Bartlett, Narendranath Epperla

https://doi.org/10.3324/haematol.2025.288946

Inherited DNA repair variants are associated with clonal hematopoiesis and cardiovascular risk in men with metastatic prostate cancer (681 Online Views)

Olisaemeka Ogbue, Yael Kusne, Osama Mosalem, Kevin Thompson, Alejandro Ferrer, Krishna Kalari, Winston Tan, Leila A. Jones, Brian A. Costello, Daniel Childs, Abhishek A. Mangaonkar, Jenna A. Fernandez, Christy Finke, Terra L. Lasho, Richard Weinshilboum, Leiwei Wang, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2025.288975

Multi-omics analysis reveals a unique epigenetic signature in MYD88 wild-type Waldenström macroglobulinemia (650 Online Views)

Karan Chohan, Jonas Paludo, Surendra Dasari, Joseph P. Novak, Jithma P. Abeykoon, Saurabh Zanwar, Zhi-Zhang Yang, Shahrzad Jalali, Vaishali Bhardwaj, Jordan E. Krull, Esteban Braggio, Michelle K. Manske, Craig B. Reeder, Sikander Ailawadhi, Asher Chanan-Khan, Prashant Kapoor, Robert A. Kyle, Morie A Gertz, Anne J. Novak, Patrizia Mondello, Stephen M. Ansell

https://doi.org/10.3324/haematol.2025.289068

Rapid and accurate identification of acute promyelocytic leukemia with a novel multiparametric flow cytometric scoring system (546 Online Views)

Alessandro Laganà, David Fanciullo, Deborah Kasmi, Concetta Anna Germano, Maria Grazia Nardacci, Emilia Scalzulli, Ida Carmosino, Maria Laura Bisegna, Clara Minotti, Federica Nostro, Maria Laura Milani, Sonia Buffolino, Maria Zaira Limongi, Claudia Ielo, Daniela Diverio, Maurizio Martelli, Massimo Breccia, Maria Stefania De Propris

https://doi.org/10.3324/haematol.2025.289104

Unemployment in patients with histiocytic neoplasms is frequent and associated with clinical and treatment characteristics (455 Online Views)

Anne S. Reiner, Dana Bossert, Allison M. Sigler, Jen Silvers, Kathleen Brewer, Diane Schriner, Priya H. Marathe, Jun J. Mao, Katherine S. Panageas, Eli L. Diamond

https://doi.org/10.3324/haematol.2025.289304

Case Reports

7

Functional impact of a deep intronic variant in the RPS19 gene detected in a case of Diamond-Blackfan anemia syndrome (408 Online Views)

Rika Kanezaki, Tsutomu Toki, Ryo Okuse, Akie Kobayashi, Moeka Sato, Sayaka Kimura, Ko Kudo, Tomohiko Sato, Tatsuhiko Tanaka, Kenichi Yoshida, Yosuke Kawai, Katsushi Tokunaga, Junko Takita, Seishi Ogawa, Kiminori Terui, Etsuro Ito

https://doi.org/10.3324/haematol.2025.300131

t(11;14) multiple myeloma patient: minimal residual disease after 10 years of follow-up - a case report (399 Online Views)

Sarah Decheiver, Anais Schavgoulidze, Sabrina Maheo, Pierre-Adrien Vion, Olivier Lucidarme, Jill Corre, Laurent Garderet

https://doi.org/10.3324/haematol.2025.288950

Common ancestral origin of indeterminate dendritic cell tumor and chronic myelomonocytic leukemia in clonal hematopoiesis (573 Online Views)

Aki Sato, Nozomi Yusa, Hiroyuki Takamori, Eigo Shimizu, Koji Jimbo, Seiko Kato, Takaaki Konuma, Kazuaki Yokoyama, Seiya Imoto, Satoshi Takahashi, Yasuhito Nannya

https://doi.org/10.3324/haematol.2025.288974

A novel GATA1 variant linking germline and somatic myelodysplastic syndrome in two patients (424 Online Views)

Nuria Revilla, Mireia Atance, Jose María Grasa, Alejandro García-Ortego, Carlos Soto, Socorro María Rodríguez-Pinilla, Teresa Arquero, Sara Perlado, Selene Ledesma, Esperanza Esquinas-Tarifa, Juana Serrano-López, Jose Luis López-Lorenzo, Diego Velasco-Rodríguez, Juan Manuel Alonso-Dominguez, Raquel Mata, Pilar Llamas-Sillero, Rocío N. Salgado, Ana Rio-Machin

https://doi.org/10.3324/haematol.2025.289133

Genetic testing guides therapy in children with refractory cytopenias (384 Online Views)

Yael Gernez, Bindu Sathi, Latha Rao, Joseph D. Hernandez, Bertil Glader, Alma-Martina Cepika, Elisabeth G. Hoyte, Kirsten Mouradian, Deepika Singh, Rosa Bacchetta, May Chien, David B. Lewis, Katja G. Weinacht

https://doi.org/10.3324/haematol.2025.288839