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Case Reports

Is Bruton tyrosine kinase a potential target to treat mast cell neoplasms? Systemic mastocytosis associated with chronic lymphoid leukemia successfully treated with acalabrutinib monotherapy: a case report and review of the literature

Division of Haematology and BMT, A.O.U. ‘Policlinico G.Rodolico-San Marco’, 95123 Catania, Italy; Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi," University of Messina
Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo and University of Pavia, Pavia
Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo and University of Pavia, Pavia
Department of Molecular Medicine, University of Pavia, Pavia
Department of Clinical and Experimental Medicine, University of Catania, 95123, Catania, Italy; Center of Experimental Oncology and Hematology, A.O.U. Policlinico “G.Rodolico-S.Marco”, 95123, Catania
Division of Haematology and BMT, A.O.U. ‘Policlinico G.Rodolico-San Marco’, 95123 Catania, Italy; Post-Graduation School of Haematology, University of Catania, A.O.U. ‘Policlinico-San Marco’, 95123 Catania
Division of Haematology and BMT, A.O.U. ‘Policlinico G.Rodolico-San Marco’, 95123 Catania, Italy; Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate "G.F.Ingrassia", University of Catania, 95131 Catania
Division of Haematology and BMT, A.O.U. ‘Policlinico G.Rodolico-San Marco’, 95123 Catania, Italy; Post-Graduation School of Haematology, University of Catania, A.O.U. ‘Policlinico-San Marco’, 95123 Catania, Italy; Dipartimento di Specialità Medico-Chirurgiche, CHIRMED, Sezione di Ematologia, Università degli Studi di Catania, 95131 Catania
Division of Haematology and BMT, A.O.U. ‘Policlinico G.Rodolico-San Marco’, 95123 Catania, Italy; Post-Graduation School of Haematology, University of Catania, A.O.U. ‘Policlinico-San Marco’, 95123 Catania, Italy; Dipartimento di Specialità Medico-Chirurgiche, CHIRMED, Sezione di Ematologia, Università degli Studi di Catania, 95131 Catania
Haematologica Early view Dec 11, 2025 https://doi.org/10.3324/haematol.2025.289116

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Early view : Case Reports
 
DOI
https://doi.org/10.3324/haematol.2025.289116
 
Published
2025-12-11
Published By
Ferrata Storti Foundation, Pavia, Italy
Print ISSN
0390-6078
Online ISSN
1592-8721
 
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Copyright (c) 2025 Ferrata Storti Foundation
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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ISSN 0390-6078 print | ISSN 1592-8721 online