CURRENT ISSUE
December, 2021
No. 106 (12)

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Editorials

Review Articles

Articles

Acute Lymphoblastic Leukemia

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations (1502 Online Views)

Željko Antić, Jiangyan Yu, Simon V. van Reijmersdal, Anke van Dijk, Linde Dekker, Wouter H. Segerink, Edwin Sonneveld, Marta Fiocco, Rob Pieters, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Ad Geurts van Kessel, Esme Waanders, Roland P. Kuiper

https://doi.org/10.3324/haematol.2020.259226

Acute Myeloid Leukemia

Plasmacytoid dendritic cells proliferation associated with acute myeloid leukemia: phenotype profile and mutation landscape (1662 Online Views)

Loria Zalmaï, Pierre-Julien Viailly, Sabeha Biichle, Meyling Cheok, Lou Soret, Fanny Angelot-Delettre, Tony Petrella, Marie-Agnès Collonge-Rame, Estelle Seilles, Sandrine Geffroy, Eric Deconinck, Etienne Daguindau, Sabrina Bouyer, Elodie Dindinaud, Victor Baunin, Magali Le Garff-Tavernier, Damien Roos-Weil, Orianne Wagner-Ballon, Véronique Salaun, Jean Feuillard, Sophie Brun, Bernard Drenou, Caroline Mayeur-Rousse, Patricia Okamba, Véronique Dorvaux, Michel Tichionni, Johann Rose, Marie Thérèse Rubio, Marie Christine Jacob, Victoria Raggueneau, Claude Preudhomme, Philippe Saas, Christophe Ferrand, Olivier Adotevi, Christophe Roumier, Fabrice Jardin, Francine Garnache-Ottou, Florian Renosi

https://doi.org/10.3324/haematol.2020.253740

Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project (1309 Online Views)

Claudia Sargas, Rosa Ayala, María Carmen Chillón, María J. Larráyoz, Estrella Carrillo-Cruz, Cristina Bilbao, Manuel Yébenes-Ramírez, Marta Llop, Inmaculada Rapado, Ramón García-Sanz, Iria Vázquez, Elena Soria, Yanira Florido-Ortega, Kamila Janusz, Carmen Botella, Josefina Serrano, David Martínez-Cuadrón, Juan Bergua, Mari Luz Amigo, Pilar Martínez-Sánchez, Mar Tormo, Teresa Bernal, Pilar Herrera-Puente, Raimundo García, Lorenzo Algarra, María J. Sayas, Lisette Costilla-Barriga, Esther Pérez-Santolalla, Inmaculada Marchante, Esperanza Lavilla-Rubira, Víctor Noriega, Juan M. Alonso-Domínguez, Miguel Á. Sanz, Joaquín Sánchez-Garcia, María T. Gómez-Casares, José A. Pérez-Simón, María J. Calasanz, Marcos González-Díaz, Joaquín Martínez-López, Eva Barragán, Pau Montesinos

https://doi.org/10.3324/haematol.2020.263806

A Pin1/PML/P53 axis activated by retinoic acid in NPM-1c acute myeloid leukemia (514 Online Views)

Rita Hleihel, Hiba El Hajj, Hsin-Chieh Wu, Caroline Berthier, Hong-Hu Zhu, Radwan Massoud, Zaher Chakhachiro, Marwan El Sabban; Hugues de The; Ali Bazarbachi

https://doi.org/10.3324/haematol.2020.274878

Acute Promyelocytic Leukemia

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative study (773 Online Views)

Sabine Kayser, Richard F. Schlenk, Delphine Lebon, Martin Carre, Katharina S. Götze, Friedrich Stölzel, Ana Berceanu, Kerstin Schäfer-Eckart, Pierre Peterlin, Yosr Hicheri, Ramy Rahme, Emmanuel Raffoux, Fatiha Chermat, Stefan W. Krause, Walter E. Aulitzky, Sophie Rigaudeau, Richard Noppeney, Celine Berthon, Martin Görner, Edgar Jost, Philippe Carassou, Ulrich Keller, Corentin Orvain, Thorsten Braun, Colombe Saillard, Ali Arar, Volker Kunzmann, Mathieu Wemeau, Maike de Wit, Dirk Niemann, Caroline Bonmati, Carsten Schwänen, Julie Abraham, Ahmad Aljijakli, Stephanie Haiat, Alwin Krämer, Albrecht Reichle, Martina Gnadler, Christophe Willekens, Karsten Spiekermann, Wolfgang Hiddemann, Carsten Müller-Tidow, Christian Thiede, Christoph Röllig, Hubert Serve, Martin Bornhäuser, Claudia D. Baldus, Eva Lengfelder, Pierre Fenaux, Uwe Platzbecker, Lionel Adès

https://doi.org/10.3324/haematol.2021.278722

Bone Marrow Transplantation

Use of the HLA-B leader to optimize cord blood transplantation (942 Online Views)

Effie W. Petersdorf, Ted Gooley, Fernanda Volt, Chantal Kenzey, Alejandro Madrigal, Caroline McKallor, Sergio Querol, Hanadi Rafii, Vanderson Rocha, Ryad Tamouza, Christian Chabannon, Annalisa Ruggeri, Eliane Gluckman

https://doi.org/10.3324/haematol.2020.264424

Cell Therapy & Immunotherapy

PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia (2609 Online Views)

Jessica Li, Sarah Whelan, Maya F. Kotturi, Deborah Meyran, Criselle D’Souza, Kyle Hansen, Spencer Liang, John Hunter, Joseph A. Trapani, Paul J. Neeson

https://doi.org/10.3324/haematol.2020.258574

Chronic Lymphocytic Leukemia

SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation (938 Online Views)

Federico Pozzo, Tamara Bittolo, Erika Tissino, Filippo Vit, Elena Vendramini, Luca Laurenti, Giovanni D’Arena, Jacopo Olivieri, Gabriele Pozzato, Francesco Zaja, Annalisa Chiarenza, Francesco Di Raimondo, Antonella Zucchetto, Riccardo Bomben, Francesca Maria Rossi, Giovanni Del Poeta, Michele Dal Bo, Valter Gattei

https://doi.org/10.3324/haematol.2020.261891

Hematopoiesis

Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis (1203 Online Views)

Sheila Bohler, Sehar Afreen, Juncal Fernandez-Orth, Eva-Maria Demmerath, Christian Molnar, Ying Wu, Julia Miriam Weiss, Venugopal Rao Mittapalli, Lukas Konstantinidis, Hagen Schmal, Mirjam Kunze, Miriam Erlacher

https://doi.org/10.3324/haematol.2020.252130

Iron Metabolism & its Disorders

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice (798 Online Views)

Manfred Nairz, Christoph Metzendorf, Maja Vujic-Spasic, Anna-Maria Mitterstiller, Andrea Schroll, David Haschka, Alexander Hoffmann, Laura von Raffay, Richard Sparla, Christian W. Huck, Heribert Talasz, Patrizia L. Moser, Martina U. Muckenthaler, Günter Weiss

https://doi.org/10.3324/haematol.2019.241745

Myeloproliferative Disorders

Bone marrow megakaryocytic activation predicts fibrotic evolution of Philadelphia-negative myeloproliferative neoplasms (1398 Online Views)

Mattia Schino, Vincenzo Fiorentino, Elena Rossi, Silvia Betti, Monica Di Cecca, Valentina Ranucci, Patrizia Chiusolo, Maurizio Martini, Valerio De Stefano, Luigi Maria Larocca

https://doi.org/10.3324/haematol.2020.264143

Non-Hodgkin Lymphoma

Plasma Cell Disorders

Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo (1273 Online Views)

Mara N. Zeissig, Duncan R. Hewett, Vasilios Panagopoulos, Krzysztof M. Mrozik, L. Bik To, Peter I. Croucher, Andrew C.W. Zannettino, Kate Vandyke

https://doi.org/10.3324/haematol.2020.253526

Red Cell Biology & its Disorders

Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria (2187 Online Views)

Antonio M. Risitano, Austin G. Kulasekararaj, Jong Wook Lee, Jaroslaw P. Maciejewski, Rosario Notaro, Robert Brodsky, Mingjun Huang, Michael Geffner, Peter Browett

https://doi.org/10.3324/haematol.2020.261826

Letters to the Editor

Daratumumab, an original approach for treating multi-refractory autoimmune cytopenia (415 Online Views)

Etienne Crickx, Sylvain Audia, Ailsa Robbins, David Boutboul, Thibault Comont, Morgane Cheminant, Eric Oksenhendler, Bertrand Godeau, Marc Michel, Matthieu Mahevas

https://doi.org/10.3324/haematol.2021.279232

Biallelic mutations in the SARS2 gene presenting as congenital sideroblastic anemia (287 Online Views)

Elia Colin, Geneviève Courtois, Chantal Brouzes, Juliette Pulman, Marion Rabant, Agnès Rötig, Hélène Taffin, Mathilde Lion-Lambert, Sylvie Fabrega, Lydie Da Costa, Mariane De Montalembert, Rémi Salomon, Olivier Hermine, Lucile Couronné

https://doi.org/10.3324/haematol.2021.279138

Melphalan dose intensity for autologous stem cell transplantation in multiple myeloma (462 Online Views)

Samer A. Srour, Denái R. Milton, Qaiser Bashir, Yago Nieto, Neeraj Saini, May Daher, Jeremy Ramdial, Jin Im, Chitra Hosing, Ruby Delgado, Elisabet Manasanch, Hans C. Lee, Sheeba Thomas, Greg Kaufman, Krina Patel, Uday Popat, Donna Weber, Robert Orlowski, Elizabeth Shpall, Richard E. Champlin, Muzaffar H. Qazilbash

https://doi.org/10.3324/haematol.2021.279179

Predicting risk of progression in relapsed multiple myeloma using traditional risk models, focal lesion assessment with PET-CT and minimal residual disease status (189 Online Views)

David Baker, Milan Bimali, Luis Carrillo, Archana Sachedina, Daisy Alapat, Md Shadiqul Hoque, Mathew Kottarathara, Richa Parikh, Amani Erra, Angel A. Mitma, Pankaj Mathur, Yetunde Ogunsesan, Lakshmi Yarlagadda, Sravani Gundarlapalli, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Guido Tricot, Carolina Schinke

https://doi.org/10.3324/haematol.2021.278779

Allogeneic hematopoietic cell transplantation outcomes in patients with Richter’s transformation (410 Online Views)

Haesook T. Kim, Peter O. Baker, Erin Parry, Matthew Davids, Edwin P. Alyea, Vincent T. Ho, Corey Cutler, John Koreth, Mahasweta Gooptu, Rizwan Romee, Sarah Nikiforow, Joseph H. Antin, Jerome Ritz, Robert J. Soiffer, Catherine J. Wu, Jennifer R. Brown

https://doi.org/10.3324/haematol.2021.279033

Platelet activation and modulation in thrombosis with thrombocytopenia syndrome associated with ChAdO×1 nCov-19 vaccine (334 Online Views)

Mariangela Scavone, Bianca Clerici, Simone Birocchi, Tatiana Mencarini, Mariagrazia Calogiuri, Claudia Ghali, Daniele Prati, Silvia Bozzi, Paolo Villa, Marco Cattaneo, Gian Marco Podda

https://doi.org/10.3324/haematol.2021.279345

Dose-adjusted EPOCH-rituximab or intensified B-NHL therapy for pediatric primary mediastinal large B-cell lymphoma (406 Online Views)

Fabian Knörr, Martin Zimmermann, Andishe Attarbaschi, Edita Kabíčková, Britta Maecker-Kolhoff, Stephanie Ruf, Ingrid Kühnle, Martin Ebinger, Anne-Kathrin Garthe, Ingrid Simonitsch-Klupp, Ilske Oschlies, Wolfram Klapper, Birgit Burkhardt, Wilhelm Woessmann

https://doi.org/10.3324/haematol.2021.278971

Lower respiratory tract infection with Staphylococcus aureus in sickle-cell adult patients with severe acute chest syndrome - the STAPHACS Study (285 Online Views)

Alexandre Elabbadi, Guillaume Voiriot, Anne Tristan, Aude Gibelin, Charlotte Verdet, Michel Djibré, Aline Santin, Etienne-Marie Jutant, Julien Lopinto, François Vandenesch, François Lionnet, Muriel Fartoukh

https://doi.org/10.3324/haematol.2021.278827

Oral azacitidine preserves favorable level of fatigue and health-related quality of life for patients with acute myeloid leukemia in remission: results from the phase 3, placebo-controlled QUAZAR AML-001 trial (514 Online Views)

Gail J. Roboz, Hartmut Döhner, Christopher Pocock, Herve Dombret, Farhad Ravandi, Jun Ho Jang, Dominik Selleslag, Jiři Mayer, Uwe M. Martens, Jane Liesveld, Teresa Bernal, Ming Chung Wang, Peiwen Yu, Ling Shi, Shien Guo, Ignazia La Torre, Barry Skikne, Qian Dong, Julia Braverman, Salem Abi Nehme, C.L. Beach, Andrew H. Wei

https://doi.org/10.3324/haematol.2021.279174

Case Reports

Dominance of an UBA1 mutant clone over a CALR mutant clone: from essential thrombocytemia to VEXAS. (655 Online Views)

Mehdi Hage-Sleiman, Sophie Lalevée, Hélène Guermouche, Fabrizia Favale, Michael Chaquin, Maxime Battistella, Jean-David Bouaziz, Martine Bagot, François Delhommeau, Florence Cordoliani, Pierre Hirsch

https://doi.org/10.3324/haematol.2021.279418

Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels (299 Online Views)

Jonathan Douxfils, Caroline Vayne, Claire Pouplard, Thomas Lecompte, Julien Favresse, Florence Potier, Emy Gasser, Valérie Mathieux, Jean-Michel Dogné, Yves Gruel, Jérôme Rollin, François Mullier

https://doi.org/10.3324/haematol.2021.279509