January, 2022
No. 107 (1)

About the Cover

Landmark papers in Hematology

Editorial

Editorials

Review Series

Indolent lymphomas

Articles

Acute Lymphoblastic Leukemia

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia (2270 Online Views)

Alaeddin Khalil, Gudrun Würthwein, Jana Golitsch, Georg Hempel, Manfred Fobker, Joachim Gerss, Anja Möricke, Martin Zimmermann, Petr Smisek, Massimo Zucchetti, Christa Nath, Andishe Attarbaschi, Arend von Stackelberg, Nicola Gökbuget, Carmelo Rizzari, Valentino Conter, Martin Schrappe, Joachim Boos, Claudia Lanvers-Kaminsky

https://doi.org/10.3324/haematol.2020.258525

Acute Myeloid Leukemia

Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and re-sensitizes acute myeloid leukemia to BCL-2 inhibition (3899 Online Views)

Bing Z. Carter, Po Yee Mak, Wenjing Tao, Marc Warmoes, Philip L. Lorenzi, Duncan Mak, Vivian Ruvolo, Lin Tan, Justin Cidado, Lisa Drew, Michael Andreeff

https://doi.org/10.3324/haematol.2020.260331

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis (2349 Online Views)

Thomas Milan, Magalie Celton, Karine Lagacé, Élodie Roques, Safia Safa-Tahar-Henni, Eva Bresson, Anne Bergeron, Josée Hebert, Soheil Meshinchi, Sonia Cellot, Frédéric Barabé, Brian T Wilhelm

https://doi.org/10.3324/haematol.2020.271619

Fusion gene detection by RNA-sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements (3589 Online Views)

Paul Kerbs, Sebastian Vosberg, Stefan Krebs, Alexander Graf, Helmut Blum, Anja Swoboda, Aarif M. N. Batcha, Ulrich Mansmann, Dirk Metzler, Caroline A. Heckman, Tobias Herold, Philipp A. Greif

https://doi.org/10.3324/haematol.2021.278436

Blood Transfusion

Beta thalassemia minor is a beneficial determinant of red blood cell storage lesion (2290 Online Views)

Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Davide Stefanoni, Francesca Cendali, Lorenzo Bertolone, Fabia Gamboni, Monika Dzieciatkowska, Pantelis Rousakis, Athina Vergaki, Vassilis Soulakis, Ourania E. Tsitsilonis, Konstantinos Stamoulis, Issidora S. Papassideri, Anastasios G. Kriebardis, Angelo D’Alessandro, Marianna H. Antonelou

https://doi.org/10.3324/haematol.2020.273946

Bone Marrow Failure

Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag (3538 Online Views)

Yoshitaka Zaimoku, Bhavisha A. Patel, Ruba Shalhoub, Emma M. Groarke, Xingmin Feng, Colin O. Wu, Neal S. Young

https://doi.org/10.3324/haematol.2021.278413

Chronic Lymphocytic Leukemia

The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia (1678 Online Views)

Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. van de Werken, Leticia G. Leon, Antoinette van Hoven-Beijen, Iris van Zuijen, Yvonne M. Mueller, Eric M. Bindels, Dick de Ridder, Mies C. Kappers-Klunne, Kirsten van Lom, Vincent H.J. van der Velden, Anton W. Langerak

https://doi.org/10.3324/haematol.2020.263756

Hematopoiesis

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cells via regulation of the p53-checkpoint pathway (2300 Online Views)

Tongjie Wang, Chengxiang Xia, Qitong Weng, Kaitao Wang, Yong Dong, Sha Hao, Fang Dong, Xiaofei Liu, Lijuan Liu, Yang Geng, Yuxian Guan, Juan Du, Tao Cheng, Hui Cheng, Jinyong Wang

https://doi.org/10.3324/haematol.2019.239186

Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance (1902 Online Views)

Martina Moras, Claude Hattab, Pedro Gonzalez-Menendez, Claudio M. Fader, Michael Dussiot, Jerome Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi Taylor, Sophie D. Lefevre, Mariano A. Ostuni

https://doi.org/10.3324/haematol.2020.257121

Myelomonocytic Leukemia

Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia (2455 Online Views)

Anna Hecht, Julia A. Meyer, Astrid Behnert, Eric Wong, Farid Chehab, Adam Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat, Jason E. Farrar, Mark Fluchel, Haydar Frangoul, Jennifer H. Han, Edward A. Kolb, Dennis J. Kuo, Margaret L. MacMillan, Luke Maese, Kelly W. Maloney, Aru Narendran, Benjamin Oshrine, Kirk R. Schultz, Maria L. Sulis, David Van Mater, Sarah K. Tasian, Wolf-Karsten Hofmann, Mignon L. Loh, Elliot Stieglitz

https://doi.org/10.3324/haematol.2020.270595

Non-Hodgkin Lymphoma

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways (2034 Online Views)

Till Braun, Markus Glass, Linus Wahnschaffe, Moritz Otte, Petra Mayer, Marek Franitza, Janine Altmüller, Michael Hallek, Stefan Hüttelmaier, Alexandra Schrader, Marco Herling

https://doi.org/10.3324/haematol.2020.267500

Phenogenomic heterogeneity of post-transplant plasmablastic lymphomas (1679 Online Views)

Rebecca J. Leeman-Neill, Craig R. Soderquist, Francesca Montanari, Patricia Raciti, David Park, Dejan Radeski, Mahesh M. Mansukhani, Vundavalli V. Murty, Susan Hsiao, Bachir Alobeid, Govind Bhagat

https://doi.org/10.3324/haematol.2020.267294

Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential (1946 Online Views)

Lennart Raman, Malaïka Van der Linden, Ciel De Vriendt, Bliede Van den Broeck, Kristoff Muylle, Dries Deeren, Franceska Dedeurwaerdere, Sofie Verbeke, Amélie Dendooven, Katrien De Grove, Saskia Baert, Kathleen Claes, Björn Menten, Fritz Offner, Jo Van Dorpe

https://doi.org/10.3324/haematol.2020.268813

Baseline SUVmax is related to tumor cell proliferation and patient outcome in follicular lymphoma (2057 Online Views)

Cédric Rossi, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, Don-Marc Franchini, Nadia Amara, Charlotte Syrykh, Pierre Bories, Lucie Oberic, Loïc Ysebaert, Laurent Martin, Selim Ramla, Philippine Robert, Claire Tabouret-Viaud, René-Olivier Casasnovas, Jean-Jacques Fournié, Christine Bezombes, Camille Laurent

https://doi.org/10.3324/haematol.2020.263194

Plasma Cell Disorders

Autologous stem cell transplantation is safe and effective for fit, older myeloma patients: exploratory results from the Myeloma XI trial (2614 Online Views)

Charlotte Pawlyn, David Cairns, Tom Menzies, John Jones, Matthew Jenner, Gordon Cook, Kevin Boyd, Mark Drayson, Martin Kaiser, Roger Owen, Walter Gregory, Gareth Morgan, Graham Jackson, Faith Davies

https://doi.org/10.3324/haematol.2020.262360

Platelet Biology & its Disorders

Post-translational polymodification of β1-tubulin regulates motor protein localization in platelet production and function (1999 Online Views)

Abdullah O. Khan, Alexandre Slater, Annabel Maclachlan, Phillip L.R. Nicolson, Jeremy A. Pike, Jasmeet S. Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G. Thomas, Neil V. Morgan

https://doi.org/10.3324/haematol.2020.270793

Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation (1256 Online Views)

Michela Faleschini, Nicole Papa, Marie-Christine Morel-Kopp, Caterina Marconi, Tania Giangregorio, Federica Melazzini, Valeria Bozzi, Marco Seri, Patrizia Noris, Alessandro Pecci, Anna Savoia, Roberta Bottega

https://doi.org/10.3324/haematol.2020.267328

Red Cell Biology & its Disorders

The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cell expansion (1622 Online Views)

Audrey Astori, Gabriel Matherat, Isabelle Munoz, Emilie-Fleur Gautier, Didier Surdez, Yaël Zermati, Frédérique Verdier, Sakina Zaidi, Vincent Feuillet, Amir Kadi, Evelyne Lauret, Olivier Delattre, Carine Lefèvre, Michaela Fontenay, Evelyne Ségal-Bendirdjian, Isabelle Dusanter-Fourt, Didier Bouscary, Olivier Hermine, Patrick Mayeux, Frédéric Pendino

https://doi.org/10.3324/haematol.2020.263558

Case Reports

Letters to the Editor

Diabetes mellitus and risk of plasma cell and lymphoproliferative disorders in 94,579 cases and 368,348 matched controls (1405 Online Views)

Urvi A. Shah, Sæmundur Rögnvaldsson, Andriy Derkach, Magnus Björkholm, Ingemar Turesson, Yael David, Malin Hultcrantz, Carlyn Tan, Hani Hassoun, Neha Korde, Alexander Lesokhin, Sham Mailankody, Sigurður Yngvi Kristinsson, C. Ola Landgren

https://doi.org/10.3324/haematol.2021.278772

Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter (1139 Online Views)

Killian Donovan, Athinoula Meli, Francesca Cendali, Kyung Chan Park, Rebecca Cardigan, Simon Stanworth, Stuart McKechnie, Angelo D’Alessandro, Peter A. Smethurst, Pawel Swietach

https://doi.org/10.3324/haematol.2021.279296

Targeting Wnt signaling in acute myeloid leukemia stem cells (1270 Online Views)

Felice Pepe, Marius Bill, Dimitrios Papaioannou, Malith Karunasiri, Allison Walker, Eric Naumann, Katiri Snyder, Parvathi Ranganathan, Adrienne Dorrance, Ramiro Garzon

https://doi.org/10.3324/haematol.2020.266155

In utero thirdhand smoke exposure modulates platelet function in a sex-dependent manner (878 Online Views)

Hamdy E.A. Ali, Ahmed B. Alarabi, Zubair A. Karim, Victor Rodriguez, Keziah R. Hernandez, Patricia A. Lozano, Medhat S. El-Halawany, Fatima Z. Alshbool, Fadi T. Khasawneh

https://doi.org/10.3324/haematol.2021.279388

Ikaros deficiency is associated with aggressive BCR-ABL1 B-cell precursor acute lymphoblastic leukemia independent of the lineage and developmental origin (890 Online Views)

Célestine Simand, Céline Keime, Aurélie Cayé, Chloé Arfeuille, Marie Passet, Rathana Kim, Hélène Cavé, Emmanuelle Clappier, Philippe Kastner, Susan Chan, Beate Heizmann

https://doi.org/10.3324/haematol.2021.279125

Planned withdrawal of dexamethasone after pomalidomide low-dose dexamethasone induction for lenalidomide-refractory multiple myeloma (ALLG MM14) (1140 Online Views)

Anna Kalff, Tiffany Khong, Malarmathy Ramachandran, P Joy Ho, Peter Mollee, James D’Rozario, Kerry Taylor, Jane Estell, Sam Norton, Roslyn Kemp, Andrew J. Mitchell, John Reynolds, Nola Kennedy, Hang Quach, Andrew Spencer

https://doi.org/10.3324/haematol.2021.278655

Signal transduction pathway involved in platelet activation in immune thrombotic thrombocytopenia after COVID-19 vaccination (1123 Online Views)

Roberta Misasi, Antonella Capozzi, Gloria Riitano, Serena Recalchi, Valeria Manganelli, Vincenzo Mattei, Agostina Longo, Manuela De Michele, Tina Garofalo, Fabio M. Pulcinelli, Maurizio Sorice

https://doi.org/10.3324/haematol.2021.279729

First report of inherited protein S deficiency caused by paternal PROS1 mosaicism (967 Online Views)

Satomi Nagaya, Keiko Maruyama, Atsushi Watanabe, Makiko Meguro-Horike, Yuta Imai, Yuki Hiroshima, Shin-Ichi Horike, Koichi Kokame, Eriko Morishita

https://doi.org/10.3324/haematol.2021.278527

Treatment with ibrutinib does not induce a TP53 clonal evolution in chronic lymphocytic leukemia (1440 Online Views)

Luciana Cafforio, Sara Raponi, Luca Vincenzo Cappelli, Caterina Ilari, Roberta Soscia, Maria Stefania De Propris, Paola Mariglia, Gian Matteo Rigolin, Antonella Bardi, Nadia Peragine, Alfonso Piciocchi, Valentina Arena, Francesca Romana Mauro, Antonio Cuneo, Anna Guarini, Robin Foa, Ilaria Del Giudice

https://doi.org/10.3324/haematol.2020.263715

Tumor suppressor function of WT1 in acute promyelocytic leukemia (1061 Online Views)

Matthew J. Christopher, Casey D. S. Katerndahl, Hayley R. LeBlanc, Tyler T. Elmendorf, Vaishali Basu, Margery Gang, Andrew J. Menssen, David H. Spencer, Eric J. Duncavage, Shamika Ketkar, Lukas D. Wartman, Sai Mukund Ramakrishnan, Christopher A. Miller, Timothy J. Ley

https://doi.org/10.3324/haematol.2021.279601