November, 2021
No. 106 (11)

About the Cover

Editorials

Review Articles

2021 European Myeloma Network review and consensus statement on smoldering multiple myeloma: how to distinguish (and manage) Dr. Jekyll and Mr. Hyde (2117 Online Views)

Pellegrino Musto, Monika Engelhardt, Jo Caers, Niccolo’ Bolli, Martin Kaiser, Niels van de Donk, Evangelos Terpos, Annemiek Broijl, Carlos Fernández de Larrea, Francesca Gay, Hartmut Goldschmidt, Roman Hajek, Annette Juul Vangsted, Elena Zamagni, Sonja Zweegman, Michele Cavo, Meletios Dimopoulos, Hermann Einsele, Heinz Ludwig, Giovanni Barosi, Mario Boccadoro, Maria-Victoria Mateos, Pieter Sonneveld, Jesus San Miguel

https://doi.org/10.3324/haematol.2021.278519

Articles

Acute Lymphoblastic Leukemia

Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia (1020 Online Views)

Rikke Hebo Larsen, Cecilie Utke Rank, Kathrine Grell, Lisbeth Nørgaard Møller, Ulrik Malthe Overgaard, Peter Kampmann, Jacob Nersting, Matilda Degn, Stine Nygaard Nielsen, Helle Holst, Birgitte Klug Albertsen, Peder Skov Wehner, Michael Thude Callesen, Jukka Kanerva, Thomas Leth Frandsen, Bodil Als-Nielsen, Lisa Lyngsie Hjalgrim, Kjeld Schmiegelow

https://doi.org/10.3324/haematol.2020.278166

Chronic Lymphocytic Leukemia

Venetoclax plus bendamustine-rituximab or bendamustine-obinutuzumab in chronic lymphocytic leukemia: final results of a phase Ib study (GO28440) (1905 Online Views)

Stephan Stilgenbauer, Franck Morschhauser, Clemens-Martin Wendtner, Guillaume Cartron, Michael Hallek, Barbara Eichhorst, Mark F. Kozloff, Thomas Giever, Gerard Lozanski, Yanwen Jiang, Huang Huang, Daniela Soriano Pignataro, William Schary, Kathryn Humphrey, Mehrdad Mobasher, Gilles Salles

https://doi.org/10.3324/haematol.2020.261107

Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration (2313 Online Views)

Deborah M. Stephens, Ken Boucher, Elizabeth Kander, Sameer A. Parikh, Erin M. Parry, Mazyar Shadman, John M. Pagel, Jennifer Cooperrider, Joanna Rhodes, Anthony Mato, Allison Winter, Brian Hill, Sameh Gaballa, Alexey Danilov, Tycel Phillips, Danielle M. Brander, Sonali M. Smith, Matthew Davids, Kerry Rogers, Martha J. Glenn, John C. Byrd

https://doi.org/10.3324/haematol.2020.256388

Chronic Myeloid Leukemia

The effect of eltrombopag in managing thrombocytopenia associated with tyrosine kinase therapy in patients with chronic myeloid leukemia and myelofibrosis (1448 Online Views)

Mahran Shoukier, Gautam Borthakur, Elias Jabbour, Farhad Ravandi, Guillermo Garcia-Manero, Tapan Kadia, Jairo Matthews, Lucia Masarova, Kiran Naqvi, Koji Sasaki, Srdan Verstovsek, Jorge Cortes

https://doi.org/10.3324/haematol.2020.260125

Hematopoiesis

Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans (1103 Online Views)

Daniel C.J. Ferguson, Juraidah Haji Mokim, Marjolein Meinders, Edmund R.R. Moody, Tom A. Williams, Sarah Cooke, Kongtana Trakarnsanga, Deborah E. Daniels, Ivan Ferrer-Vicens, Deborah Shoemark, Chartsiam Tipgomut, Katherine A. Macinnes, Marieangela C. Wilson, Belinda K. Singleton, Jan Frayne

https://doi.org/10.3324/haematol.2020.256347

Hemostasis

Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro (1358 Online Views)

Thomas Hoefer, Akshita Rana, Be'eri Niego, Shweta Jagdale, Hugo J. Albers, Elizabeth E. Gardiner, Robert K. Andrews, Andries D. Van der Meer, Christoph E. Hagemeyer, Erik Westein

https://doi.org/10.3324/haematol.2020.250761

Iron Metabolism & its Disorders

Myelodysplastic Syndromes

Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations (1273 Online Views)

Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak

https://doi.org/10.3324/haematol.2020.254193

Non-Hodgkin Lymphoma

CDKN2A deletion is a frequent event associated with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) (1162 Online Views)

Francesco Maura, Anna Dodero, Cristiana Carniti, Niccolò Bolli, Martina Magni, Valentina Monti, Antonello Cabras, Daniel Leongamornlert, Federico Abascal, Benjamin Diamond, Bernardo Rodriguez-Martin, Jorge Zamora, Adam Butler, Inigo Martincorena, Jose M. C. Tubio, Peter J. Campbell, Annalisa Chiappella, Giancarlo Pruneri, Paolo Corradini

https://doi.org/10.3324/haematol.2020.262659

Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma (1638 Online Views)

Youssef Youssef, Vrajesh Karkhanis, Wing Keung Chan, Frankie Jeney, Alessandro Canella, Xiaoli Zhang, Shelby Sloan, Alexander Prouty, JoBeth Helmig-Mason, Liudmyla Tsyba, Walter Hanel, Xuguang Zheng, Pu Zhang, Ji-Hyun Chung, David M. Lucas, Zachary Kauffman, Karilyn Larkin, Anne M. Strohecker, Hatice G. Ozer, Rosa Lapalombella, Hui Zhou, Zijun Y. Xu-Monette, Ken H. Young, Ruolan Han, Elmar Nurmemmedov, Gerard Nuovo, Kami Maddocks, John C. Byrd, Robert A. Baiocchi, Lapo Alinari

https://doi.org/10.3324/haematol.2020.268235

A prognostic index predicting survival in transformed Waldenström macroglobulinemia (1552 Online Views)

Eric Durot, Lukshe Kanagaratnam, Saurabh Zanwar, Efstathios Kastritis, Shirley D’Sa, Ramon Garcia-Sanz, Cécile Tomowiak, Bénédicte Hivert, Elise Toussaint, Caroline Protin, Jithma P. Abeykoon, Thomas Guerrero-Garcia, Gilad Itchaki, Josephine M. Vos, Anne-Sophie Michallet, Sophie Godet, Jehan Dupuis, Stéphane Leprêtre, Joshua Bomsztyk, Pierre Morel, Véronique Leblond, Steven P. Treon, Meletios A. Dimopoulos, Prashant Kapoor, Alain Delmer, Jorge J. Castillo

https://doi.org/10.3324/haematol.2020.262899

Platelet Biology & its Disorders

Platelet proteome and function in X−linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome (1674 Online Views)

Daniel Bergemalm, Sofia Ramström, Caroline Kardeby, Kjell Hultenby, Anna Göthlin Eremo, Carina Sihlbom, Jörgen Bergström, Jan Palmblad, Maria Åström

https://doi.org/10.3324/haematol.2020.249805

Red Cell Biology & its Disorders

Recapitulation of erythropoiesis in congenital dyserythropoietic anemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities (1079 Online Views)

Caroline Scott, Damien J. Downes, Jill M. Brown, Robert Beagrie, Aude-Anais Olijnik, Matthew Gosden, Ron Schwessinger, Christopher A. Fisher, Anna Rose, David J.P Ferguson, Errin Johnson, Quentin A. Hill, Steven Okoli, Raffaele Renella, Kate Ryan, Marjorie Brand, Jim Hughes, Noemi B.A. Roy, Douglas R. Higgs, Christian Babbs, Veronica J. Buckle

https://doi.org/10.3324/haematol.2020.260158

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality (1095 Online Views)

Aaron Issaian, Ariel Hay, Monika Dzieciatkowska, Domenico Roberti, Silverio Perrotta, Zsuzsanna Darula, Jasmina Redzic, Micheal P. Busch, Grier P. Page, Stephen C. Rogers, Allan Doctor, Kirk C. Hansen, Elan Z. Eisenmesser, James C. Zimring, Angelo D’Alessandro

https://doi.org/10.3324/haematol.2020.278252

Letters to the Editor

Cluster of differentiation 33 single nucleotide polymorphism rs12459419 is a predictive factor in patients with nucleophosmin1-mutated acute myeloid leukemia receiving gemtuzumab ozogamicin (989 Online Views)

Katrin Teich, Julia Krzykalla, Silke Kapp-Schwoerer, Verena I. Gaidzik, Richard F. Schlenk, Peter Paschka, Daniela Weber, Walter Fiedler, Michael W.M. Kühn, Thomas Schroeder, Karin Mayer, Michael Lübbert, Dhanya Ramachandran, Axel Benner, Arnold Ganser, Hartmut Döhner, Michael Heuser, Konstanze Döhner, Felicitas Thol

https://doi.org/10.3324/haematol.2021.278894

Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia (478 Online Views)

Jessica Leonard, Joelle SJ Wolf, Michelle Degnin, Christopher A. Eide, Dorian LaTocha, Kyle Lenz, Beth Wilmot, Charles G. Mullighan, Mignon Loh, Stephen P Hunger, Brian J Druker, Marc M Loriaux, Jeffrey W Tyner, Bill H Chang

https://doi.org/10.3324/haematol.2021.278692

IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kδ inhibitor idelalisib (844 Online Views)

Veronika Sandova, Gabriela Mladonicka Pavlasova, Vaclav Seda, Katerina Amruz Cerna, Sonali Sharma, Veronika Palusova, Yvona Brychtova, Sarka Pospisilova, Stacey M. Fernandes, Anna Panovska, Michael Doubek, Matthew S. Davids, Jennifer R. Brown, Jiri Mayer, Marek Mraz

https://doi.org/10.3324/haematol.2021.278644

A novel classification of hematologic conditions in patients with Fanconi anemia (638 Online Views)

Yvonne Lisa Behrens, Gudrun Göhring, Randa Bawadi, Sümeyye Cöktü, Christina Reimer, Beatrice Hoffmann, Birte Sänger, Simon Käfer, Felicitas Thol, Miriam Erlacher, Charlotte M. Niemeyer, Irith Baumann, Reinhard Kalb, Detlev Schindler, Christian Peter Kratz

https://doi.org/10.3324/haematol.2021.279332

The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy (1303 Online Views)

Claire C. Homan, Sarah L. King-Smith, David M. Lawrence, Peer Arts, Jinghua Feng, James Andrews, Mark Armstrong, Thuong Ha, Julia Dobbins, Michael W. Drazer, Kai Yu, Csaba Bödör, Alan Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Jude Fitzgibbon, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V. Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Rienhoff, Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Velloso, Benedict Yan, Paul Liu, Lucy A. Godley, Andreas W. Schreiber, Christopher N. Hahn, Hamish S. Scott, Anna L. Brown

https://doi.org/10.3324/haematol.2021.278762

Allogeneic hematopoietic stem cell transplantation from non-sibling 10/10 HLA-matched related donors: a single-center experience (642 Online Views)

Yaoyao Shen, Jiaqian Qi, Jia Chen, Yang Xu, Feng Chen, Xiao Ma, Miao Miao, Shengli Xue, Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, Depei Wu, Ying Wang

https://doi.org/10.3324/haematol.2021.278933

Case Reports

Massive cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (1682 Online Views)

Sara Bonato, Andrea Artoni, Anna Lecchi, Ghil Schwarz, Silvia La Marca, Lidia Padovan, Marigrazia Clerici, Chiara Guadino, Giacomo Pietro Comi, Armando Tripodi, Flora Peyvandi

https://doi.org/10.3324/haematol.2021.279246

Intracerebral hemorrhage associated with vaccine-induced thrombotic thrombocytopenia following ChAdOx1 nCOVID-19 vaccine in a pregnant woman (1261 Online Views)

Daniela P. Mendes-de-Almeida, Remy Martins-Gonçalves, Renata Morato-Santos, Gustavo Adolpho C. de Carvalho, Silas A. Martins, Lohanna Palhinha, Vanessa Sandim, Elyzabeth Avvad-Portari, Fernando A. Bozza, Robson Q. Monteiro, Patrícia T. Bozza, Pedro Kurtz

https://doi.org/10.3324/haematol.2021.279407