CURRENT ISSUE
July, 2021
No. 106 (7)

Obituary

About the Cover

Editorials

Perspective Articles

Review Articles

Articles

Acute Lymphoblastic Leukemia

WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia (911 Online Views)

Juncheng Hu, Tianci Wang, Jin Xu, Sanyun Wu, Liyuan Wang, Hexiu Su, Jue Jiang, Ming Yue, Jingchao Wang, Donghai Wang, Peng Li, Fuling Zhou, Yu Liu, Guoliang Qing, Hudan Liu

https://doi.org/10.3324/haematol.2019.231126

A multicenter total therapy strategy for de novo adult Philadelphia chromosome positive acute lymphoblastic leukemia patients: final results of the GIMEMA LAL1509 protocol (1336 Online Views)

Sabina Chiaretti, Michela Ansuinelli, Antonella Vitale, Loredana Elia, Mabel Matarazzo, Alfonso Piciocchi, Paola Fazi, Francesco Di Raimondo, Lidia Santoro, Francesco Fabbiano, Catello Califano, Giovanni Martinelli, Francesca Ronco, Felicetto Ferrara, Nicola Cascavilla, Catia Bigazzi, Alessandra Tedeschi, Simona Sica, Nicola Di Renzo, Angela Melpignano, Germana Beltrami, Marco Vignetti, Robin Foa

https://doi.org/10.3324/haematol.2020.260935

Acute Myeloid Leukemia

Comparison of total body irradiation versus non-total body irradiation containing regimens for de novo acute myeloid leukemia in children (1049 Online Views)

Christopher E. Dandoy, Stella M. Davies, Kwang Woo Ahn, Yizeng He, Anders E. Kolb, John Levine, Stephanie Bo-Subait, Hisham Abdel-Azim, Neel Bhatt, Joseph Chewing, Shahinaz Gadalla, Nicholas Gloude, Robert Hayashi, Nahal R. Lalefar, Jason Law, Margaret MacMillan, Tracy O'Brien, Timothy Prestidge, Akshay Sharma, Peter Shaw, Lena Winestone, Mary Eapen

https://doi.org/10.3324/haematol.2020.249458

Cell Therapy & Immunotherapy

Anti-RhD antibody therapy modulates human natural killer cell function (617 Online Views)

Shlomo Elias, Inbal Kol, Shira Kahlon, Rajaa Amore, Mariam Zeibak, Dror Mevorach, Uriel Elchalal, Orly Zelig, Ofer Mandelboim

https://doi.org/10.3324/haematol.2019.238097

Fc-engineering significantly improves the recruitment of immune effector cells by anti-ICAM-1 antibody MSH-TP15 for myeloma therapy (883 Online Views)

Katja Klausz, Michael Cieker, Christian Kellner, Thies Rösner, Anna Otte, Steffen Krohn, Anja Lux, Falk Nimmerjahn, Thomas Valerius, Martin Gramatzki, Matthias Peipp

https://doi.org/10.3324/haematol.2020.251371

Chronic Lymphocytic Leukemia

Efficacy of minimal residual disease driven immune-intervention after allogeneic hematopoietic stem cell transplantation for high-risk chronic lymphocytic leukemia: results of a prospective multicenter trial (825 Online Views)

Olivier Tournilhac, Magali Le Garff-Tavernier, Stéphanie Nguyen Quoc, Edouard Forcade, Patrice Chevallier, Faezeh Legrand-Izadifar, Gandhi Laurent Damaj, David Michonneau, Cécile Tomowiak, Cécile Borel, Corentin Orvain, Pascal Turlure, Rabah Redjou, Gaëlle Guillerm, Laure Vincent, Celestine Simand, Richard Lemal, Claire Quiney, Patricia Combes, Bruno Pereira, Laure Calvet, Aurélie Cabrespine, Jacques-Olivier Bay, Véronique Leblond, Nathalie Dhédin, French Innovative Leukemia Organization (FILO), Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)

https://doi.org/10.3324/haematol.2019.239566

Chronic Myeloid Leukemia

Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity (771 Online Views)

Lando Janssen, Nicole M.A. Blijlevens, Meggie M.C.M. Drissen, Esmée A. Bakker, Malou A.H. Nuijten, Jeroen J.W.M. Janssen, Silvie Timmers, Maria T.E. Hopman

https://doi.org/10.3324/haematol.2020.247767

Hematopoiesis

Hemophagocytosis

A pilot study of ruxolitinib as a front-line therapy for 12 children with secondary hemophagocytic lymphohistiocytosis (1262 Online Views)

Qing Zhang, Ang Wei, Hong-Hao Ma, Li Zhang, Hong-Yun Lian, Dong Wang, Yun-Ze Zhao, Lei Cui, Wei-Jing Li, Ying Yang, Tian-You Wang, Zhi-Gang Li, Rui Zhang

https://doi.org/10.3324/haematol.2020.253781

Hemostasis

Factor VIII activity and bleeding risk during prophylaxis for severe hemophilia A: a population pharmacokinetic model (900 Online Views)

Andreas Tiede, Faraizah Abdul Karim, Victor Jiménez-Yuste, Robert Klamroth, Sandra Lejniece, Takashi Suzuki, Andreas Groth, Elena Santagostino

https://doi.org/10.3324/haematol.2019.241554

Myeloproliferative Disorders

Crucial role of hematopoietic JAK2 V617F in the development of aortic aneurysms (783 Online Views)

Tetsuro Yokokawa, Tomofumi Misaka, Yusuke Kimishima, Kento Wada, Keiji Minakawa, Koichi Sugimoto, Takafumi Ishida, Soji Morishita, Norio Komatsu, Kazuhiko Ikeda, Yasuchika Takeishi

https://doi.org/10.3324/haematol.2020.264085

Non-Hodgkin Lymphoma

Impact on survival through consolidation radiotherapy for diffuse large B-cell lymphoma: a comprehensive meta-analysis (913 Online Views)

Martin D. Berger, Sven Trelle, Annina E. Büchi, Sabrina Jegerlehner, Codruta Ionescu, Thierry Lamy de la Chapelle, Urban Novak

https://doi.org/10.3324/haematol.2020.249680

Outcomes of Burkitt lymphoma with central nervous system involvement: evidence from a large multicenter cohort study (1013 Online Views)

Adam S. Zayac, Andrew M. Evens, Alexey Danilov, Stephen D. Smith, Deepa Jagadeesh, Lori A. Leslie, Catherine Wei, Seo-Hyun Kim, Seema Naik, Suchitra Sundaram, Nishitha Reddy, Umar Farooq, Vaishalee P. Kenkre, Narendranath Epperla, Kristie A. Blum, Nadia Khan, Daulath Singh, Juan P. Alderuccio, Amandeep Godara, Maryam Sarraf Yazdy, Catherine Diefenbach, Emma Rabinovich, Gaurav Varma, Reem Karmali, Yusra Shao, Asaad Trabolsi, Madelyn Burkart, Peter Martin, Sarah Stettner, Ayushi Chauhan, Yun Kyong Choi, Allandria Straker-Edwards, Andreas Klein, Michael C. Churnetski, Kirsten M. Boughan, Stephanie Berg, Bradley M. Haverkos, Victor M. Orellana-Noia, Christopher D'Angelo, David A. Bond, Seth M. Maliske, Ryan Vaca, Gabriella Magarelli, Amy Sperling, Max J. Gordon, Kevin A. David, Malvi Savani, Paolo Caimi, Manali Kamdar, Matthew A Lunning, Neil Palmisiano, Parameswaran Venugopal, Craig A. Portell, Veronika Bachanova, Tycel Phillips, Izidore S. Lossos, Adam J. Olszewski

https://doi.org/10.3324/haematol.2020.270876

Plasma Cell Disorders

Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression (1071 Online Views)

Antonio G. Solimando, Matteo C. Da Vià, Patrizia Leone, Paola Borrelli, Giorgio A. Croci, Paula Tabares, Andreas Brandl, Giuseppe Di Lernia, Francesco P. Bianchi, Silvio Tafuri, Torsten Steinbrunn, Alessandra Balduini, Assunta Melaccio, Simona De Summa, Antonella Argentiero, Hilka Rauert-Wunderlich, Maria A. Frassanito, Paolo Ditonno, Erik Henke, Wolfram Klapper, Roberto Ria, Carolina Terragna, Leo Rasche, Andreas Rosenwald, K. Martin Kortüm, Michele Cavo, Domenico Ribatti, Vito Racanelli, Hermann Einsele, Angelo Vacca, Andreas Beilhack

https://doi.org/10.3324/haematol.2019.239913

Lenalidomide before and after autologous stem cell transplantation for transplant-eligible patients of all ages in the randomized, phase III, Myeloma XI trial (1109 Online Views)

Graham H. Jackson, Faith E. Davies, Charlotte Pawlyn, David A. Cairns, Alina Striha, Corinne Collett, Anna Waterhouse, John R. Jones, Bhuvan Kishore, Mamta Garg, Cathy D. Williams, Kamaraj Karunanithi, Jindriska Lindsay, David Allotey, Salim Shafeek, Matthew W. Jenner, Gordon Cook, Nigel H. Russell, Martin F. Kaiser, Mark T. Drayson, Roger G. Owen, Walter M. Gregory, Gareth J. Morgan, UK NCRI Haematological Oncology Clinical Studies Group

https://doi.org/10.3324/haematol.2020.247130

Platelet Biology & its Disorders

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling (752 Online Views)

Amanda J. Unsworth, Alexander P. Bye, Tanya Sage, Renato S. Gaspar, Nathan Eaton, Caleb Drew, Alexander Stainer, Neline Kriek, Peter J. Volberding, James L. Hutchinson, Ryan Riley, Sarah Jones, Stuart J. Mundell, Weiguo Cui, Hervé Falet, Jonathan M. Gibbins

https://doi.org/10.3324/haematol.2019.223529

Red Cell Biology & its Disorders

In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor (1633 Online Views)

Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore, Charity Atkins, Edward R. Long, Monica N. Montoute, Zining Wu, Wendy Halsey, Dean E. McNulty, Daniela Ennulat, Lourdes Rueda, Melissa Pappalardi, Ryan G. Kruger, Michael T. McCabe, Ali Raoof, Roger Butlin, Alexandra Stowell, Mark Cockerill, Ian Waddell, Donald Ogilvie, Juan Luengo, Allan Jordan, Andrew B. Benowitz

https://doi.org/10.3324/haematol.2020.248658

Letters to the Editor

Mixed myeloid chimerism and relapse of myelofibrosis after allogeneic stem cell transplantation (738 Online Views)

Samer A. Srour, Amanda Olson, Stefan O. Ciurea, Parth Desai, Qaiser Bashir, Betul Oran, Prithviraj Bose, Rohtesh Mehta, Keyur P. Patel, Naveen Pemmaraju, Naval Daver, Srdan Verstovsek, Richard E. Champlin, Uday R. Popat

https://doi.org/10.3324/haematol.2019.223503

Mixed-lineage leukemia protein modulates the loading of let-7a onto AGO1 by recruiting RAN (557 Online Views)

Shouhai Zhu, Zhihong Chen, Dan Jiang, Ruiheng Wang, Xiaoyan Cheng, Dan Li, Qiongyu Xv, Fei Zhao, Wootae Kim, Guijie Guo, Chunjun Zhao, Zhenkun Lou, Han Liu

https://doi.org/10.3324/haematol.2020.268474

Glenzocimab does not impact glycoprotein VI-dependent inflammatory hemostasis (604 Online Views)

Soumaya Jadoui, Ophélie Le Chapelain, Véronique Ollivier, Ali Mostefa-Kara, Lucas Di Meglio, Sébastien Dupont, Angèle Gros, Mialitiana Solo Nomenjanahary, Jean-Philippe Desilles, Mikaël Mazighi, Bernhard Nieswandt, Stéphane Loyau, Martine Jandrot-Perrus, Pierre H Mangin, Benoit Ho-Tin-Noé

https://doi.org/10.3324/haematol.2020.270439

Comparison of CD38 antibodies in vitro and ex vivo mechanisms of action in multiple myeloma (860 Online Views)

Michelle Kinder, Nizar J. Bahlis, Fabio Malavasi, Bart de Goeij, Alexander Babich, Jocelyn Sendecki, Joshua Rusbuldt, Kevin Bellew, Colleen Kane, Niels W.C.J. van de Donk

https://doi.org/10.3324/haematol.2020.268656

Immunophenotypic changes of leukemic blasts in children with relapsed/refractory B-cell precursor acute lymphoblastic leukemia who have been treated with blinatumomab (789 Online Views)

Ekaterina Mikhailova, Evgeny Gluhanyuk, Olga Illarionova, Elena Zerkalenkova, Svetlana Kashpor, Natalia Miakova, Yulia Diakonova, Yulia Olshanskaya, Larisa Shelikhova, Galina Novichkova, Michael Maschan, Alexey Maschan, Alexander Popov

https://doi.org/10.3324/haematol.2019.241596

Entospletinib and obinutuzumab in patients with relapsed/refractory chronic lymphocytic leukemia and B-cell malignancies (832 Online Views)

Adam S. Kittai, Scott Best, Bria Thurlow, Vi Lam, Taylor Hashiguchi, Shaun Goodyear, Daniel O. Persky, Craig Okada, Byung Park, Stephen E. Spurgeon, Alexey V. Danilov

https://doi.org/10.3324/haematol.2020.270298

An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia (710 Online Views)

Yoichi Tanaka, Allen Eng Juh Yeoh, Takaya Moriyama, Chi-Kong Li, Ko Kudo, Yuki Arakawa, Jassada Buaboonnam, Hui Zhang, Hsi-Che Liu, Hany Ariffin, Zhiwei Chen, Shirley K.Y. Kham, Rina Nishii, Daisuke Hasegawa, Junya Fujimura, Dai Keino, Kensuke Kondoh, Atsushi Sato, Takahiro Ueda, Masaki Yamamoto, Yuichi Taneyama, Moeko Hino, Masatoshi Takagi, Akira Ohara, Etsuro Ito, Katsuyoshi Koh, Hiroki Hori, Atsushi Manabe, Jun J. Yang, Motohiro Kato

https://doi.org/10.3324/haematol.2020.266320

Case Reports

A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria (532 Online Views)

Sarah Ducamp, Sara Luscieti, Xènia Ferrer-Cortès, Gaël Nicolas, Hana Manceau, Katell Peoc’h, Yvette Y. Yien, Caroline Kannengiesser, Laurent Gouya, Herve Puy, Mayka Sanchez

https://doi.org/10.3324/haematol.2020.272450

Light chain proteinuria revealing mu-heavy chain disease: an atypical presentation of Waldenström macroglobulinemia in two cases (612 Online Views)

Hélène Vergneault, Djaouida Bengoufa, Aline Frazier-Mironer, Isabelle Brocheriou, Samuel Bitoun, Camille Villesuzanne, Alexis Talbot, Stéphanie Harel, Bertrand Arnulf, Bruno Royer

https://doi.org/10.3324/haematol.2020.277137