August, 2021
No. 106 (8)

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Editorials

Review Articles

European Myeloma Network perspective on CAR T-Cell therapies for multiple myeloma (2082 Online Views)

Benedetto Bruno, Ralph Wäsch, Monika Engelhardt, Francesca Gay, Luisa Giaccone, Mattia D’Agostino, Luis-Gerardo Rodríguez-Lobato, Sophia Danhof, Nico Gagelmann, Nicolaus Kröger, Rakesh Popat, Niels W.C.J. van de Donk, Evangelos Terpos, Meletios A. Dimopoulos, Pieter Sonneveld, Hermann Einsele, Mario Boccadoro

https://doi.org/10.3324/haematol.2020.276402

Articles

Acute Lymphoblastic Leukemia

DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch (1185 Online Views)

Michaela Novakova, Marketa Zaliova, Karel Fiser, Barbora Vakrmanova, Lucie Slamova, Alena Musilova, Monika Brüggemann, Matthias Ritgen, Eva Fronkova, Tomas Kalina, Jan Stary, Lucie Winkowska, Peter Svec, Alexandra Kolenova, Jan Stuchly, Jan Zuna, Jan Trka, Ondrej Hrusak, Ester Mejstrikova

https://doi.org/10.3324/haematol.2020.250423

Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemia (1055 Online Views)

Greta Forlani, Mariam Shallak, Alessandra Tedeschi, Ilaria Cavallari, Ambroise Marçais, Olivier Hermine, Roberto S. Accolla

https://doi.org/10.3324/haematol.2020.272468

Pediatric-inspired chemotherapy incorporating pegaspargase is safe and results in high rates of minimal residual disease negativity in adults up to age 60 with Philadelphia chromosome-negative acute lymphoblastic leukemia (2494 Online Views)

Mark B. Geyer, Ellen K. Ritchie, Arati V. Rao, Shreya Vemuri, Jessica Flynn, Meier Hsu, Sean M. Devlin, Mikhail Roshal, Qi Gao, Madhulika Shukla, Jose M. Salcedo, Peter Maslak, Martin S. Tallman, Dan Douer, Jae H. Park

https://doi.org/10.3324/haematol.2020.251686

Fenofibrate reduces osteonecrosis without affecting antileukemic efficacy in dexamethasone-treated mice (670 Online Views)

Emily R. Finch, Monique A. Payton, David A. Jenkins, Xiangjun Cai, Lie Li, Seth E. Karol, Mary V. Relling, Laura J. Janke

https://doi.org/10.3324/haematol.2020.252767

Acute Myeloid Leukemia

CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity (1150 Online Views)

Julia C. Gutjahr, Elisabeth Bayer, Xiaobing Yu, Julia M. Laufer, Jan P. Höpner, Suzana Tesanovic, Andrea Härzschel, Georg Auer, Tanja Rieß, Astrid Salmhofer, Eva Szenes, Theresa Haslauer, Valerie Durand-Onayli, Andrea Ramspacher, Sandra P. Pennisi, Marc Artinger, Nadja Zaborsky, Alexandre Chigaev, Fritz Aberger, Daniel Neureiter, Lisa Pleyer, Daniel F. Legler, Veronique Orian-Rousseau, Richard Greil, Tanja N. Hartmann

https://doi.org/10.3324/haematol.2019.231944

Survival of patients with newly diagnosed high-grade myeloid neoplasms who do not meet standard trial eligibility (973 Online Views)

Mary-Elizabeth M. Percival, Megan Othus, Sarah Mirahsani, Kelda M. Gardner, Carole Shaw, Anna B. Halpern, Pamela S. Becker, Paul C. Hendrie, Mohamed L. Sorror, Roland B. Walter, Elihu H. Estey

https://doi.org/10.3324/haematol.2020.254938

A phase I/II study of the combination of quizartinib with azacitidine or low-dose cytarabine for the treatment of patients with acute myeloid leukemia and myelodysplastic syndrome (2017 Online Views)

Mahesh Swaminathan, Hagop M Kantarjian, Mark Levis, Veronica Guerra, Gautam Borthakur, Yesid Alvarado, Courtney D DiNardo, Tapan Kadia, Guillermo Garcia-Manero, Maro Ohanian, Naval Daver, Marina Konopleva, Naveen Pemmaraju, Alessandra Ferrajoli, Michael Andreeff, Nitin Jain, Zeev Estrov, Elias J Jabbour, William G Wierda, Sherry Pierce, Maria Rhona Pinsoy, Lianchun Xiao, Farhad Ravandi, Jorge E Cortes

https://doi.org/10.3324/haematol.2020.263392

Bone Marrow Transplantation

Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect (1150 Online Views)

Eileen Haring, Franziska M. Uhl, Geoffroy Andrieux, Michele Proietti, Alla Bulashevska, Barbara Sauer, Lukas M. Braun, Enrique de Vega Gomez, Philipp R. Esser, Stefan F. Martin, Dietmar Pfeifer, Marie Follo, Annette Schmitt-Graeff, Joerg Buescher, Justus Duyster, Bodo Grimbacher, Melanie Boerries, Erika L. Pearce, Robert Zeiser, Petya Apostolova

https://doi.org/10.3324/haematol.2019.242990

Cell Therapy & Immunotherapy

Endothelial damage and dysfunction in acute graft-versus-host disease (1449 Online Views)

Steffen Cordes, Zeinab Mokhtari, Maria Bartosova, Sarah Mertlitz, Katarina Riesner, Yu Shi, Jörg Mengwasser, Martina Kalupa, Aleixandria McGeary, Johanna Schleifenbaum, Jens Schrezenmeier, Lars Bullinger, Maribel Diaz-Ricart, Marta Palomo, Enric Carrreras, Gernot Beutel, Claus Peter Schmitt, Andreas Beilhack, Olaf Penack

https://doi.org/10.3324/haematol.2020.253716

Hemostasis

An international, multicenter study of intravenous bevacizumab for bleeding in hereditary hemorrhagic telangiectasia: the InHIBIT-Bleed study (1547 Online Views)

Hanny Al-Samkari, Raj S. Kasthuri, Joseph G. Parambil, Hasan A. Albitar, Yahya A. Almodallal, Carolina Vázquez, Marcelo M. Serra, Sophie Dupuis-Girod, Craig B. Wilsen, Justin P. McWilliams, Evan H. Fountain, James R. Gossage, Clifford R. Weiss, Muhammad A. Latif, Assaf Issachar, Meir Mei-Zahav, Mary E. Meek, Miles Conrad, Josanna Rodriguez-Lopez, David J. Kuter, Vivek N. Iyer

https://doi.org/10.3324/haematol.2020.261859

Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia (4813 Online Views)

Karina Althaus, Peter Möller, Günalp Uzun, Anurag Singh, Annika Beck, Martin Bettag, Hans Bösmüller, Martina Guthoff, Franziska Dorn, Gabor C. Petzold, Hans Henkes, Nils Heyne, Hassan Jumaa, Kornelia Kreiser, Caroline Limpach, Beate Luz, Matthias Maschke, Janis A. Müller, Jan Münch, Simon Nagel, Bernd Pötzsch, Jens Müller, Christoph Schlegel, Andreas Viardot, Hansjörg Bäzner, Marc Wolf, Lisann Pelzl, Verena Warm, Winfried A. Willinek, Jochen Steiner, Nicole Schneiderhan-Marra, Dominik Vollherbst, Ulrich J. Sachs, Falko Fend, Tamam Bakchoul

https://doi.org/10.3324/haematol.2021.279000

Hematopoiesis

MYB bi-allelic targeting abrogates primitive clonogenic progenitors while the emergence of primitive blood cells is not affected (1099 Online Views)

Zahir Shah, Elena S. Filonenko, Vasily Ramensky, Chenyu Fan, Cuihua Wang, Hanif Ullah, Baoyun Zhang, Pavel Volchkov, Igor M. Samokhvalov

https://doi.org/10.3324/haematol.2020.249193

BMP signaling is required for postnatal murine hematopoietic stem cell self-renewal (600 Online Views)

Sarah Warsi, Ulrika Blank, Maria Dahl, Tan Hooi Min Grahn, Ludwig Schmiderer, Silja Andradottir, Stefan Karlsson

https://doi.org/10.3324/haematol.2019.236125

Myelodysplastic Syndromes

Co-occurrence of cohesin complex and Ras signaling mutations during progression from myelodysplastic syndromes to secondary acute myeloid leukemia (1048 Online Views)

Marta Martín-Izquierdo, María Abáigar, Jesús M Hernández-Sánchez, David Tamborero, Félix López-Cadenas, Fernando Ramos, Eva Lumbreras, Andrés Madinaveitia-Ochoa, Marta Megido, Jorge Labrador, Javier Sánchez-Real, Carmen Olivier, Julio Dávila, Carlos Aguilar, Juan N Rodríguez, Guillermo Martín-Nuñez, Sandra Santos-Mínguez, Cristina Miguel-García, Rocío Benito, María Díez-Campelo, Jesús M Hernández-Rivas

https://doi.org/10.3324/haematol.2020.248807

Non-Hodgkin Lymphoma

Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B-cell-type diffuse large B-cell lymphoma (827 Online Views)

Lorenz Thurner, Sylvia Hartmann, Moritz Bewarder, Natalie Fadle, Evi Regitz, Claudia Schormann, Natalia Quiroga, Maria Kemele, Wolfram Klapper, Andreas Rosenwald, Lorenz Trümper, Rainer Maria Bohle, Anna Nimmesgern, Christina Körbel, Matthias W. Lascke, Michael D. Menger, Stefan Barth, Boris Kubuschok, Anja Mottok, Dominic Kaddu-Mulindwa, Martin-Leo Hansmann, Viola Pöschel, Gerhard Held, Niels Murawski, Stephan Stilgenbauer, Frank Neumann, Klaus-Dieter Preuss, Michael Pfreundschuh

https://doi.org/10.3324/haematol.2019.241653

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma (869 Online Views)

Christian W. Thorball, Tiphaine Oudot-Mellakh, Nava Ehsan, Christian Hammer, Federico A. Santoni, Jonathan Niay, Dominique Costagliola, Cécile Goujard, Laurence Meyer, Sophia S. Wang, Shehnaz K. Hussain, Ioannis Theodorou, Matthias Cavassini, Andri Rauch, Manuel Battegay, Matthias Hoffmann, Patrick Schmid, Enos Bernasconi, Huldrych F. Günthard, Pejman Mohammadi, Paul J. McLaren, Charles S. Rabkin, Caroline Besson, Jacques Fellay

https://doi.org/10.3324/haematol.2020.247023

Letters to the Editor

The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment (667 Online Views)

Thai Hoa Tran, Jonathan V. Nguyen, Adrian Stecula, Jon Akutagawa, Anthony V. Moorman, Benjamin S. Braun, Andrej Sali, Charles G. Mullighan, Neil P. Shah, Yunfeng Dai, Meenakshi Devidas, Kathryn G. Roberts, Catherine C. Smith, Mignon L. Loh

https://doi.org/10.3324/haematol.2020.261354

The TRPV2 channel mediates Ca2+ influx and the Δ9-THC-dependent decrease in osmotic fragility in red blood cells (733 Online Views)

Anouar Belkacemi, Claudia Fecher Trost, René Tinschert, Daniel Flormann, Mahsa Malihpour, Christian Wagner, Markus R. Meyer, Andreas Beck, Veit Flockerzi

https://doi.org/10.3324/haematol.2020.274951

Rationale for the combination of venetoclax and ibrutinib in T-prolymphocytic leukemia (1075 Online Views)

Christoph Kornauth, Charles Herbaux, Bernd Boidol, Chantal Guillemette, Patrick Caron, Marius E. Mayerhöfer, Stéphanie Poulain, Olivier Tournilhac, Tea Pemovska, Stephen J.F. Chong, Emiel van der Kouwe, Lukas Kazianka, Georg Hopfinger, Daniel Heintel, Roland Jäger, Markus Raderer, Ulrich Jäger, Ingrid Simonitsch-Klupp, Wolfgang R. Sperr, Stefan Kubicek, Matthew S. Davids, Philipp B. Staber

https://doi.org/10.3324/haematol.2020.271304

Stem cell yield and transplantation in transplant-eligible newly diagnosed multiple myeloma patients receiving daratumumab + bortezomib/thalidomide/dexamethasone in the phase 3 CASSIOPEIA study (1022 Online Views)

Cyrille Hulin, Fritz Offner, Philippe Moreau, Murielle Roussel, Karim Belhadj, Lotfi Benboubker, Denis Caillot, Thierry Facon, Laurent Garderet, Frédérique Kuhnowski, Anne-Marie Stoppa, Brigitte Kolb, Mourad Tiab, Kon-Siong Jie, Matthijs Westerman, Jérôme Lambert, Lixia Pei, Veronique Vanquickelberghe, Carla de Boer, Jessica Vermeulen, Tobias Kampfenkel, Pieter Sonneveld, Niels W.C.J. van de Donk

https://doi.org/10.3324/haematol.2020.261842

The significance of gradient expression of chromosome region maintenance protein 1 (exportin1) in large cell lymphoma (689 Online Views)

Jithma P. Abeykoon, Paul J. Hampel, Rebecca L. King, Adam J. Wood, Melissa C Larson, Kevin E. Nowakowski, Saurabh S. Zanwar, Surendra Dasari, Gordon J. Ruan, Aishwarya Ravindran, Linda E. Wellik, Jonas Paludo, Brian K. Link, James R. Cerhan, Stephen M. Ansell, Grzegorz S. Nowakowski, Carrie A Thompson, Matthew J. Maurer, Kerstin Wenzl, Anne J. Novak, Xiaosheng Wu, Thomas M. Habermann, Thomas E. Witzig

https://doi.org/10.3324/haematol.2020.278277

Ibrutinib interferes with innate immunity in chronic lymphocytic leukemia patients during COVID-19 infection (901 Online Views)

Stefania Fiorcari, Claudio Giacinto Atene, Rossana Maffei, Giulia Debbia, Leonardo Potenza, Mario Luppi, Roberto Marasca

https://doi.org/10.3324/haematol.2020.277392

Derepression of retroelements in acute myeloid leukemia with 3q aberrations (581 Online Views)

Jagoda Mika, Sophie Ottema, Sandra Kiehlmeier, Sabrina Kruse, Leonie Smeenk, Judith Müller, Sabrina Schweiggert, Carl Herrmann, Mathijs Sanders, Ruud Delwel, Stefan Gröschel

https://doi.org/10.3324/haematol.2020.277400

One third of alloantibodies in patients with sickle cell disease transfused with African blood are missed by the standard red blood cell test panel (809 Online Views)

Lilian A. Boateng, Henk Schonewille, Peter C. Ligthart, Ahmad Javadi, Barbera Veldhuisen, Alex Osei-Akoto, Yvonne Dei-Adomakoh, Imelda Bates, C. Ellen van der Schoot

https://doi.org/10.3324/haematol.2021.278451

Case Reports

Non-inhibitory antibodies inducing increased emicizumab clearance in a severe haemophilia A inhibitor patient (1147 Online Views)

Annie Harroche, Thibaud Sefiane, Maximilien Desvages, Delphine Borgel, Dominique Lasne, Caterina Casari, Ivan Peyron, Laurent Frenzel, Stéphanie Chhun, Peter J. Lenting, Cécile Bally

https://doi.org/10.3324/haematol.2021.278579

Post-mortem findings in vaccine-induced thrombotic thombocytopenia (17707 Online Views)

Cristoforo Pomara, Francesco Sessa, Marcello Ciaccio, Francesco Dieli, Massimiliano Esposito, Sebastiano Fabio Garozzo, Antonino Giarratano, Daniele Prati, Francesca Rappa, Monica Salerno, Claudio Tripodo, Paolo Zamboni, Pier Mannuccio Mannucci

https://doi.org/10.3324/haematol.2021.279075

Errata Corrige

Errata

Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research (381 Online Views)

Aleksandr Lazaryan, Michelle Dolan, Mei-Jie Zhang, Hai-Lin Wang, Mohamed A. Kharfan-Dabaja, David I. Marks, Nelli Bejanyan, Edward Copelan, Navneet S. Majhail, Edmund K. Waller, Nelson Chao, Tim Prestidge, Taiga Nishihori, Partow Kebriaei, Yoshihiro Inamoto, Betty Hamilton, Shahrukh K. Hashmi, Rammurti T. Kamble, Ulrike Bacher, Gerhard C. Hildebrandt, Patrick J. Stiff, Joseph McGuirk, Ibrahim Aldoss, Amer M. Beitinjaneh, Lori Muffly, Ravi Vij, Richard F. Olsson, Michael Byrne, Kirk R. Schultz, Mahmoud Aljurf, Matthew Seftel, Mary Lynn Savoie, Bipin N. Savani, Leo F. Verdonck, Mitchell S. Cairo, Nasheed Hossain, Vijaya Raj Bhatt, Haydar A. Frangoul, Hisham Abdel-Azim, Monzr Al Malki, Reinhold Munker, David Rizzieri, Nandita Khera, Ryotaro Nakamura, Olle Ringdén, Marjolein van der Poel, Hemant S. Murthy, Hongtao Liu, Shahram Mori, Satiro De Oliveira, Javier Bolaños-Meade, Mahmoud Elsawy, Pere Barba, Sunita Nathan, Biju George, Attaphol Pawarode, Michael Grunwald, Vaibhav Agrawal, Youjin Wang, Amer Assal, Paul Castillo Caro, Yachiyo Kuwatsuka, Sachiko Seo, Celalettin Ustun, Ioannis Politikos, Hillard M. Lazarus, Wael Saber, Brenda M. Sandmaier, Marcos De Lima, Mark Litzow, Veronika Bachanova, Daniel Weisdorf

https://doi.org/10.3324/haematol.2021.279046