June, 2021
No. 106 (6)

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Editorials

Review Articles

Articles

Acute Lymphoblastic Leukemia

Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia (1120 Online Views)

Chujing Zhang, Stella Amanda, Cheng Wang, Tze King Tan, Muhammad Zulfaqar Ali, Wei Zhong Leong, Ley Moy Ng, Shojiro Kitajima, Zhenhua Li, Allen Eng Juh Yeoh, Shi Hao Tan, Takaomi Sanda

https://doi.org/10.3324/haematol.2019.245639

Philadelphia-like acute lymphoblastic leukemia is associated with minimal residual disease persistence and poor outcome. First report of the minimal residual disease-oriented GIMEMA LAL1913 (2098 Online Views)

Sabina Chiaretti, Monica Messina, Irene Della Starza, Alfonso Piciocchi, Luciana Cafforio, Marzia Cavalli, Akram Taherinasab, Michela Ansuinelli, Loredana Elia, Guglielmo Albertini Petroni, Roberta La Starza, Martina Canichella, Alessia Lauretti, Maria Cristina Puzzolo, Valentina Pierini, Alessandra Santoro, Orietta Spinelli, Valerio Apicella, Saveria Capria, Francesco Di Raimondo, Paolo De Fabritiis, Cristina Papayannidis, Anna Candoni, Roberto Cairoli, Marco Cerrano, Nicola Fracchiolla, Daniele Mattei, Chiara Cattaneo, Antonella Vitale, Enrico Crea, Paola Fazi, Cristina Mecucci, Alessandro Rambaldi, Anna Guarini, Renato Bassan, Robin Foà

https://doi.org/10.3324/haematol.2020.247973

Acute Myeloid Leukemia

Bone Marrow Failure

A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia (1531 Online Views)

Hiroki Mizumaki, Kazuyoshi Hosomichi, Kohei Hosokawa, Takeshi Yoroidaka, Tatsuya Imi, Yoshitaka Zaimoku, Takamasa Katagiri, Mai Anh Thi Nguyen, Dung Cao Tran, Mahmoud Ibrahim Yousef Elbadry, Kazuhisa Chonabayashi, Yoshinori Yoshida, Hiroyuki Takamatsu, Tatsuhiko Ozawa, Fumihiro Azuma, Hiroyuki Kishi, Yoichi Fujii, Seishi Ogawa, Atsushi Tajima, Shinji Nakao

https://doi.org/10.3324/haematol.2020.247809

Bone Marrow Transplantation

Post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prevention in haploidentical transplantation for adult acute lymphoblastic leukemia (1637 Online Views)

Arnon Nagler, Abraham S. Kanate, Myriam Labopin, Fabio Ciceri, Emanuele Angelucci, Yener Koc, Zafer Gülbas, William Arcese, Johanna Tischer, Pietro Pioltelli, Hakan Ozdogu, Boris Afanasyev, Depei Wu, Mutlu Arat, Zinaida Peric, Sebastian Giebel, Bipin Savani, Mohamad Mohty

https://doi.org/10.3324/haematol.2020.247296

Allogeneic hematopoietic cell transplantation with non-myeloablative conditioning for patients with hematologic malignancies: Improved outcomes over two decades (1028 Online Views)

Jason P. Cooper, Barry E. Storer, Noa Granot, Boglark Gyurkocza, Mohamed L. Sorror, Thomas R. Chauncey, Judith Shizuru, Georg-Nikolaus Franke, Michael B. Maris, Michael Boyer, Benedetto Bruno, Firoozeh Sahebi, Amelia A. Langston, Parameswaran Hari, Edward D. Agura, Søren Lykke Petersen, Richard T. Maziarz, Wolfgang Bethge, Julie Asch, Jonathan A. Gutman, Gitte Olesen, Andrew M. Yeager, Kai Hübel, William J. Hogan, David G. Maloney, Marco Mielcarek, Paul J. Martin, Mary E.D. Flowers, George E. Georges, Ann E. Woolfrey, H. Joachim Deeg, Bart L. Scott, George B. McDonald, Rainer Storb, Brenda M. Sandmaier

https://doi.org/10.3324/haematol.2020.248187

Chronic Lymphocytic Leukemia

Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia (984 Online Views)

Nyla A. Heerema, Natarajan Muthusamy, Qiuhong Zhao, Amy S. Ruppert, Heather Breidenbach, Leslie A. Andritsos, Michael R. Grever, Kami J. Maddocks, Jennifer Woyach, Farrukh Awan, Meixiao Long, Amber Gordon, Caitlin Coombes, John C. Byrd

https://doi.org/10.3324/haematol.2018.212571

Coagulation & its Disorders

Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk (935 Online Views)

Rhodri J. King, Katharina Schuett, Christian Tiede, Vera Jankowski, Vicky John, Abhi Trehan, Katie Simmons, Sreenivasan Ponnambalam, Robert F. Storey, Colin W.G. Fishwick, Michael J. McPherson, Darren C. Tomlinson, Ramzi A. Ajjan

https://doi.org/10.3324/haematol.2019.239558

Deciphering the Ets-1/2-mediated transcriptional regulation of F8 gene identifies a minimal F8 promoter for hemophilia A gene therapy (900 Online Views)

Rosella Famà, Ester Borroni, Simone Merlin, Chiara Airoldi, Silvia Pignani, Alessia Cucci, Davide Corà, Valentina Bruscaggin, Sharon Scardellato, Stefania Faletti, Giuliana Pelicci, Mirko Pinotti, Gillian E. Walker, Antonia Follenzi

https://doi.org/10.3324/haematol.2019.239202

miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis (1299 Online Views)

Ana B. Arroyo, María P. Fernández-Pérez, Alberto del Monte, Sonia Águila, Raúl Méndez, Rebecca Hernández-Antolín, Nuria García-Barber, Ascensión M de los Reyes-García, Paula González-Jiménez, María I. Arcas, Vicente Vicente, Rosario Menéndez, Vicente Andrés, Rocío González-Conejero, Constantino Martínez

https://doi.org/10.3324/haematol.2019.240226

Hematopoiesis

Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells (993 Online Views)

Miner Xie, Shanshan Zhang, Fang Dong, Qingyun Zhang, Jinhong Wang, Chenchen Wang, Caiying Zhu, Sen Zhang, Bingqing Luo, Peng Wu, Hideo Ema

https://doi.org/10.3324/haematol.2019.239251

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice (1021 Online Views)

Sara Fañanas-Baquero, Israel Orman, Federico Becerra Aparicio, Silvia Bermudez de Miguel, Jordi Garcia Merino, Rosa Yañez, Yolanda Fernandez Sainz, Rebeca Sánchez, Mercedes Dessy-Rodríguez, Omaira Alberquilla, David Alfaro, Agustin Zapata, Juan A. Bueren, Jose Carlos Segovia, Oscar Quintana-Bustamante

https://doi.org/10.3324/haematol.2019.233924

Mobilization efficiency is critically regulated by fat via marrow PPARδ (821 Online Views)

Tomohide Suzuki, Shinichi Ishii, Masakazu Shinohara, Yuko Kawano, Kanako Wakahashi, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Michito Hamada, Satoru Takahashi, Tomoyuki Furuyashiki, Nguan Soon Tan, Toshimitsu Matsui, Yoshio Katayama

https://doi.org/10.3324/haematol.2020.265751

Hodgkin Lymphoma

Whole-slide image analysis of the tumor microenvironment identifies low B-cell content as a predictor of adverse outcome in patients with advanced-stage classical Hodgkin lymphoma treated with BEACOPP (892 Online Views)

Ron Daniel Jachimowicz, Luise Pieper, Sarah Reinke, Artur Gontarewicz, Annette Plütschow, Heinz Haverkamp, Leonie Frauenfeld, Falko Fend, Mathis Overkamp, Franziska Jochims, Christoph Thorns, Martin Leo Hansmann, Peter Möller, Andreas Rosenwald, Harald Stein, Hans Christian Reinhardt, Peter Borchmann, Bastian von Tresckow, Andreas Engert, Wolfram Klapper

https://doi.org/10.3324/haematol.2019.243287

Non-Hodgkin Lymphoma

Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target (1636 Online Views)

Hugo Larose, Nina Prokoph, Jamie D. Matthews, Michaela Schlederer, Sandra Högler, Ali F. Alsulami, Stephen P. Ducray, Edem Nuglozeh, Feroze M.S. Fazaludeen, Ahmed Elmouna, Monica Ceccon, Luca Mologni, Carlo Gambacorti-Passerini, Gerald Hoefler, Cosimo Lobello, Sarka Pospisilova, Andrea Janikova, Wilhelm Woessmann, Christine Damm-Welk, Martin Zimmermann, Alina Federova, Andrea Malone, Owen Smith, Mariusz Wasik, Giorgio Inghirami, Laurence Lamant, Tom L. Blundell, Wolfram Klapper, Olaf Merkel, G.A. Amos Burke, Shahid Mian, Ibraheem Ashankyty, Lukas Kenner, Suzanne D. Turner

https://doi.org/10.3324/haematol.2019.238766

Brentuximab vedotin in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone as frontline treatment for patients with CD30-positive B-cell lymphomas (1829 Online Views)

Jakub Svoboda, Steven M. Bair, Daniel J. Landsburg, Sunita Dwivedy Nasta, Sarah J. Nagle, Stefan K. Barta, Nadia Khan, Joanne Filicko-O'Hara, Sameh Gaballa, Lauren Strelec, Elise Chong, Sheryl Mitnick, Terease S. Waite, Cara King, Hatcher Ballard, Matthew Youngman, James Gerson, John P. Plastaras, Amit Maity, Agata M. Bogusz, Stacy S. Hung, Hisae Nakamura, Reza Nejati, Christian Steidl, Megan Lim, Marco Ruella, Stephen J. Schuster

https://doi.org/10.3324/haematol.2019.238675

Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma (1127 Online Views)

Naoki Oishi, Tanya Hundal, Jessica L. Phillips, Surendra Dasari, Guangzhen Hu, David S. Viswanatha, Rong He, Ming Mai, Hailey K. Jacobs, Nada H. Ahmed, Sergei I. Syrbu, Youssef Salama, Jennifer R. Chapman, Francisco Vega, Jagmohan Sidhu, N. Nora Bennani, Alan L. Epstein, L. Jeffrey Medeiros, Mark W. Clemens, Roberto N. Miranda, Andrew L. Feldman

https://doi.org/10.3324/haematol.2019.245860

Plasma Cell Disorders

Subcutaneous daratumumab in patients with relapsed or refractory multiple myeloma: Part 2 of the open-label, multicenter, dose-escalation phase 1b study (PAVO) (1607 Online Views)

Jesus San-Miguel, Saad Z. Usmani, Maria-Victoria Mateos, Niels W.C.J. van de Donk, Jonathan L. Kaufman, Philippe Moreau, Albert Oriol, Torben Plesner, Lotfi Benboubker, Kevin Liu, Peter Hellemans, Tara Masterson, Pamela L. Clemens, Man Luo, Andrew Farnsworth, Hareth Nahi, Ajai Chari

https://doi.org/10.3324/haematol.2019.243790

Letters to the Editor

The survival impact of maintenance lenalidomide: an analysis of real-world data from the Canadian Myeloma Research Group national database (1674 Online Views)

Hannah M. Cherniawsky, Vishal Kukreti, Donna Reece, Esther Masih-Khan, Arleigh McCurdy, Victor H. Jimenez-Zepeda, Michael Sebag, Kevin Song, Darrell White, Julie Stakiw, Richard LeBlanc, Anthony Reiman, Muhammad Aslam, Martha Louzada, Rami Kotb, Engin Gul, Eshetu Atenafu, Christopher P. Venner

https://doi.org/10.3324/haematol.2020.259093

No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma (873 Online Views)

Shin Yeu Ong, Jing Quan Lim, Nicholas Grigoropoulos, Yurike Laurensia, Dachuan Huang, Burton Kuan Hui Chia, Daryl Cheah Ming Zhe, Sahil Ajit Saraf, Chee Leong Cheng, Wen-Yu Chuang, Ming-Chung Kuo, Yi-Jiun Su, Colin Phipps, Chandramouli Nagarajan, Yuh Shan Lee, Daryl Tan Chen Lung, Lee-Yung Shih, Yeow Tee Goh, Soon Thye Lim, Choon Kiat Ong

https://doi.org/10.3324/haematol.2020.269209

Antimicrobial resistance is a risk factor for mortality in adults with sickle cell disease (709 Online Views)

Andrew Srisuwananukorn, Jin Han, Rasha Raslan, Michel Gowhari, Faiz Hussain, Franklin Njoku, Robert E Molokie, Victor R. Gordeuk, Santosh L. Saraf

https://doi.org/10.3324/haematol.2020.267872

Rapid decline in estimated glomerular filtration rate in sickle cell anemia: results of a multicenter pooled analysis (806 Online Views)

Kenneth I. Ataga, Qingning Zhou, Vimal K. Derebail, Santosh L. Saraf, Jane S. Hankins, Laura R. Loehr, Melanie E. Garrett, Allison E. Ashley-Koch, Jianwen Cai, Marilyn J. Telen

https://doi.org/10.3324/haematol.2020.267419

Serum monoclonal component in chronic lymphocytic leukemia: baseline correlations and prognostic impact (1015 Online Views)

Pablo Mozas, Juan A. Pineyroa, Ferran Nadeu, Laura Magnano, Andrea Rivero, Alfredo Rivas-Delgado, Alex Bataller, Aleix Fabregat, Eva Gine, Tycho Baumann, Neus Villamor, Juan Ignacio Arostegui, Marta Aymerich, Armando Lopez-Guillermo, Elias Campo, Julio Delgado

https://doi.org/10.3324/haematol.2020.263228

Homozygous Southeast Asian ovalocytosis in five live-born neonates (870 Online Views)

Amanda A. Lavinya, Ruzzieatul A. Razali, Munirah A. Razak, Rashidah Mohamed, Emmanuel J. Moses, Meera Soundararajan, Lesley J. Bruce, Jeyanthy Eswaran, Narazah Mohd Yusoff

https://doi.org/10.3324/haematol.2020.268581

Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance (930 Online Views)

Stine U. Mikkelsen, Setareh Safavi, Konstantinos Dimopoulos, Colm J. O’Rourke, Mette K. Andersen, Mette S. Holm, Claus W. Marcher, Jesper B. Andersen, Jakob W. Hansen, Kirsten Grønbæk

https://doi.org/10.3324/haematol.2020.263319

Minimal residual disease monitoring in acute myeloid leukemia with non-A/B/D-NPM1 mutations by digital polymerase chain reaction: feasibility and clinical use (947 Online Views)

Auriane Lesieur, Xavier Thomas, Olivier Nibourel, Nicolas Boissel, Laurène Fenwarth, Stéphane De Botton, Elise Fournier, Karine Celli-Lebras, Emmanuel Raffoux, Christian Recher, Juliette Lambert, Céline Berthon, Arnaud Pigneux, Raphael Itzykson, Pascal Turlure, Cécile Pautas, Jacques Vargaftig, Claude Preudhomme, Hervé Dombret, Nicolas Duployez

https://doi.org/10.3324/haematol.2020.260133

Genome wide association study of silent cerebral infarction in sickle cell disease (HbSS and HbSC) (756 Online Views)

John N. Brewin, Helen Rooks, Kate Gardner, Harry Senior, Mrinmayi Morje, Hamel Patel, David Calvet, Pablo Bartolucci, Swee-Lay Thein, Stephan Menzel, David C. Rees

https://doi.org/10.3324/haematol.2020.265827

MK2 is a therapeutic target for high-risk multiple myeloma (1323 Online Views)

Chunyan Gu, Haibo Cheng, Hongbao Yang, Yong Bian, Yaohui Wang, Yifen Zhang, Michael Pisano, Gang Hu, Ye Yang

https://doi.org/10.3324/haematol.2017.182121

Comments

Breast dose matters (304 Online Views)

Renee M. Moadel, Jean-Ju Sheen, Leonard M. Freeman, Linda Broyde-Haramati

https://doi.org/10.3324/haematol.2019.219584