February, 2020
No. 105 (2)

About the Cover

Editorials

Centenary Review

Review Articles

Articles

Hematopoiesis

The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function (1276 Online Views)

Andreas Brown, Desiree Schuetz, Yang Han, Deidre Daria, Kalpana J. Nattamai, Karina Eiwen, Vadim Sakk, Johannes Pospiech, Thomas Saller, Gary van Zant, Wolfgang Wagner, Hartmut Geiger

https://doi.org/10.3324/haematol.2018.213009

Interferon regulatory factor 2 binding protein 2b regulates neutrophil versus macrophage fate during zebrafish definitive myelopoiesis (1308 Online Views)

Luxiang Wang, Shuo Gao, Haihong Wang, Chang Xue, Xiaohui Liu, Hao Yuan, Zixuan Wang, Saijuan Chen, Zhu Chen, Hugues de Thé, Yiyue Zhang, Wenqing Zhang, Jun Zhu, Jun Zhou

https://doi.org/10.3324/haematol.2019.217596

Red Cell Biology & its Disorders

Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis (2338 Online Views)

Rick Huisjes, Asya Makhro, Esther Llaudet-Planas, Laura Hertz, Polina Petkova-Kirova, Liesbeth P. Verhagen, Silvia Pignatelli, Minke A.E. Rab, Raymond M. Schiffelers, Elena Seiler, Wouter W. van Solinge, Joan-LLuis Vives Corrons, Lars Kaestner, Maria Mañú-Pereira, Anna Bogdanova, Richard van Wijk

https://doi.org/10.3324/haematol.2018.188151

Clinicopathological features, treatment approaches, and outcomes in Rosai-Dorfman disease (19558 Online Views)

Gaurav Goyal, Aishwarya Ravindran, Jason R. Young, Mithun V. Shah, N. Nora Bennani, Mrinal M. Patnaik, Grzegorz S. Nowakowski, Gita Thanarajasingam, Thomas M. Habermann, Robert Vassallo, Taimur Sher, Sameer A. Parikh, Karen L. Rech, Ronald S. Go

https://doi.org/10.3324/haematol.2019.219626

Myelodysplastic Syndromes

Genome analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki (2705 Online Views)

Masataka Taguchi, Hiroyuki Mishima, Yusuke Shiozawa, Chisa Hayashida, Akira Kinoshita, Yasuhito Nannya, Hideki Makishima, Makiko Horai, Masatoshi Matsuo, Shinya Sato, Hidehiro Itonaga, Takeharu Kato, Hiroaki Taniguchi, Daisuke Imanishi, Yoshitaka Imaizumi, Tomoko Hata, Motoi Takenaka, Yukiyoshi Moriuchi, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa, Koh-ichiro Yoshiura, Yasushi Miyazaki

https://doi.org/10.3324/haematol.2019.219386

Myeloproliferative Neoplasms

Molecular quantification of tissue disease burden is a new biomarker and independent predictor of survival in mastocytosis (1315 Online Views)

Georg Greiner, Michael Gurbisz, Franz Ratzinger, Nadine Witzeneder, Svenja Verena Class, Gregor Eisenwort, Ingrid Simonitsch-Klupp, Harald Esterbauer, Matthias Mayerhofer, Leonhard Müllauer, Wolfgang R. Sperr, Peter Valent, Gregor Hoermann

https://doi.org/10.3324/haematol.2019.217950

Myeloid Neoplasms

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis (1581 Online Views)

Veronica Caraffini, Olivia Geiger, Angelika Rosenberger, Stefan Hatzl, Bianca Perfler, Johannes L. Berg, Clarice Lim, Herbert Strobl, Karl Kashofer, Silvia Schauer, Christine Beham-Schmid, Gerald Hoefler, Klaus Geissler, Franz Quehenberger, Walter Kolch, Dimitris Athineos, Karen Blyth, Albert Wölfler, Heinz Sill, Armin Zebisch

https://doi.org/10.3324/haematol.2018.209650

Chronic Myeloid Leukemia

Acute Myeloid Leukemia

Comparisons of commonly used front-line regimens on survival outcomes in patients aged 70 years and older with acute myeloid leukemia (1289 Online Views)

Chetasi Talati, Varun C Dhulipala, Mar tine Extermann, Najla Al Ali, Jongphil Kim, Rami Komrokji, Kendra Sweet, Andrew Kuykendall, Marina Sehovic, Tea Reljic, Benjamin Djulbegovic, Jeffrey E. Lancet

https://doi.org/10.3324/haematol.2018.208637

Alternative donor transplantation for acute myeloid leukemia in patients aged ≥50 years: young HLA-matched unrelated or haploidentical donor? (2206 Online Views)

Miguel-Angel Perales, Benjamin Tomlinson, Mei-Jie Zhang, Andrew St. Martin, Amer Beitinjaneh, John Gibson, William Hogan, Natasha Kekre, Hillard Lazarus, David Marks, Joseph McGuirk, Rizwan Romee, Melhem Solh, John E. Wagner, Daniel J. Weisdorf, Marcos de Lima, Mary Eapen

https://doi.org/10.3324/haematol.2018.215202

Allogeneic stem cell transplantation using HLA-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: a study from the Acute Leukemia Working Party of the EBMT (1594 Online Views)

Xavier Poiré, Myriam Labopin, Emmanuelle Polge, Edouard Forcade, Arnold Ganser, Liisa Volin, Mauricette Michallet, Didier Blaise, Ibrahim Yakoub-Agha, Johan Maertens, Carlos Richard Espiga, Jan Cornelissen, Jürgen Finke, Mohamad Mohty, Jordi Esteve, Arnon Nagler

https://doi.org/10.3324/haematol.2019.216168

Non-Hodgkin Lymphoma

MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavorable prognosis (4570 Online Views)

Joost S. Vermaat, Sebastiaan F. Somers, Liesbeth C. de Wreede, Willem Kraan, Ruben A.L. de Groen, Anne M. R. Schrader, Emile D. Kerver, Cornelis G. Scheepstra, Henriëtte Berenschot, Wendy Deenik, Jurgen Wegman, Rianne Broers, Jan-Paul D. de Boer, Marcel Nijland, Tom van Wezel, Hendrik Veelken, Marcel Spaargaren, Arjen H. Cleven, Marie José Kersten, Steven T. Pals

https://doi.org/10.3324/haematol.2018.214122

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia (3353 Online Views)

Barbara Maurer, Harini Nivarthi, Bettina Wingelhofer, Ha Thi Thanh Pham, Michaela Schlederer, Tobias Suske, Reinhard Grausenburger, Ana-Iris Schiefer, Michaela Prchal-Murphy, Doris Chen, Susanne Winkler, Olaf Merkel, Christoph Kornauth, Maximilian Hofbauer, Birgit Hochgatterer, Gregor Hoermann, Andrea Hoelbl-Kovacic, Jana Prochazkova, Cosimo Lobello, Abbarna A. Cumaraswamy, Johanna Latzka, Melitta Kitzwögerer, Andreas Chott, Andrea Janikova, Šárka Pospíšilova, Joanna I. Loizou, Stefan Kubicek, Peter Valent, Thomas Kolbe, Florian Grebien, Lukas Kenner, Patrick T. Gunning, Robert Kralovics, Marco Herling, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard Moriggl

https://doi.org/10.3324/haematol.2019.216986

Chronic Lymphocytic Leukemia

Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia (3241 Online Views)

Fary Diop, Riccardo Moia, Chiara Favini, Elisa Spaccarotella, Lorenzo De Paoli, Alessio Bruscaggin, Valeria Spina, Lodovico Terzi-di-Bergamo, Francesca Arruga, Chiara Tarantelli, Clara Deambrogi, Silvia Rasi, Ramesh Adhinaveni, Andrea Patriarca, Simone Favini, Sruthi Sagiraju, Clive Jabangwe, Ahad A. Kodipad, Denise Peroni, Francesca R. Mauro, Ilaria Del Giudice, Francesco Forconi, Agostino Cortelezzi, Francesco Zaja, Riccardo Bomben, Francesca Maria Rossi, Carlo Visco, Annalisa Chiarenza, Gian Matteo Rigolin, Roberto Marasca, Marta Coscia, Omar Perbellini, Alessandra Tedeschi, Luca Laurenti, Marina Motta, David Donaldson, Phil Weir, Ken Mills, Patrick Thornton, Sarah Lawless, Francesco Bertoni, Giovanni Del Poeta, Antonio Cuneo, Antonia Follenzi, Valter Gattei, Renzo Luciano Boldorini, Mark Catherwood, Silvia Deaglio, Robin Foà, Gianluca Gaidano°, Davide Rossi°

https://doi.org/10.3324/haematol.2019.219550

Plasma Cell Disorders

Daratumumab-based regimens are highly effective and well tolerated in relapsed or refractory multiple myeloma regardless of patient age: subgroup analysis of the phase 3 CASTOR and POLLUX studies (4005 Online Views)

Maria-Victoria Mateos, Andrew Spencer, Ajay K. Nooka, Ludek Pour, Katja Weisel, Michele Cavo, Jacob P. Laubach, Gordon Cook, Shinsuke Iida, Lotfi Benboubker, Saad Z. Usmani, Sung-Soo Yoon, Nizar J. Bahlis, Christopher Chiu, Jon Ukropec, Jordan M. Schecter, Xiang Qin, Lisa O’Rourke, Meletios A. Dimopoulos

https://doi.org/10.3324/haematol.2019.217448

Complications in Hematology

Ibrutinib induces multiple functional defects in the neutrophil response against Aspergillus fumigatus (1718 Online Views)

Damien Blez, Marion Blaize, Carole Soussain, Alexandre Boissonnas, Aïda Meghraoui-Kheddar, Natacha Menezes, Anaïs Portalier, Christophe Combadière, Véronique Leblond, David Ghez, Arnaud Fekkar

https://doi.org/10.3324/haematol.2019.219220

Hemostasis

Increased incidence of cancer in the follow-up of obstetric antiphospholipid syndrome within the NOH-APS cohort (2409 Online Views)

Jean-Christophe Gris, Éve Mousty, Sylvie Bouvier, Sylvie Ripart, Éva Cochery-Nouvellon, Pascale Fabbro-Peray, Jonathan Broner, Vincent Letouzey, Antonia Pérez-Martin

https://doi.org/10.3324/haematol.2018.213991

Coagulation & its Disorders

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance (9109 Online Views)

Senna Staessens, Frederik Denorme, Olivier Francois, Linda Desender, Tom Dewaele, Peter Vanacker, Hans Deckmyn, Karen Vanhoorelbeke, Tommy Andersson, Simon F. De Meyer

https://doi.org/10.3324/haematol.2019.219881

Stem Cell Transplantation

Validation of Minnesota acute graft-versus-host disease Risk Score (2713 Online Views)

Margaret L. MacMillan, Todd E. DeFor, Shernan G. Holtan, Armin Rashidi, Bruce R. Blazar, Daniel J. Weisdorf

https://doi.org/10.3324/haematol.2019.220970

Guidelines

Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) (26984 Online Views)

Ibrahim Yakoub-Agha, Christian Chabannon, Peter Bader, Grzegorz W. Basak, Halvard Bonig, Fabio Ciceri, Selim Corbacioglu, Rafael F. Duarte, Hermann Einsele, Michael Hudecek, Marie José Kersten, Ulrike Köhl, Jürgen Kuball, Stephan Mielke, Mohamad Mohty, John Murray, Arnon Nagler, Stephen Robinson, Riccardo Saccardi, Fermin Sanchez-Guijo, John A. Snowden, Micha Srour, Jan Styczynski, Alvaro Urbano-Ispizua, Patrick J. Hayden, Nicolaus Kröger

https://doi.org/10.3324/haematol.2019.229781

Online Only Articles

Letters to the Editor

CD117hi expression identifies a human fetal hematopoietic stem cell population with high proliferation and self-renewal potential (1234 Online Views)

Loïc Maillard, Sandra Sanfilippo, Carine Domenech, Nassima Kasmi, Laurence Petit, Sébastien Jacques, Anne-Lise Delezoide, Fabien Guimiot, Soria Eladak, Delphine Moison, Nour Nicolas, Virginie Rouiller-Fabre, Stéphanie Pozzi-Godin, Benoit Mennesson, Marie-Laure Brival, Franck Letourneur, Thierry Jaffredo, Christine Chomienne, Michèle Souyri

https://doi.org/10.3324/haematol.2018.207811

Sequential cellular niches control the generation of enucleated erythrocytes from human pluripotent stem cells (1535 Online Views)

Jun Shen, Yaoyao Zhu, Cuicui Lyu, Zicen Feng, Shuzhen Lyu, Yuping Zhao, Dixie L. Hoyle, Guangzhen Ji, Weimin Miao, Xiaobing Zhang, Linzhao Cheng, Robert A. Brodsky, Tao Cheng, Zack Z. Wang

https://doi.org/10.3324/haematol.2018.211664

Characterization of the phenotype of human eosinophils and their progenitors in the bone marrow of healthy individuals (11737 Online Views)

Marwan Hassani, Selma van Staveren, Erinke van Grinsven, Marije Bartels, Kiki Tesselaar, Guus Leijte, Matthijs Kox, Peter Pickkers, Nienke Vrisekoop, Leo Koenderman

https://doi.org/10.3324/haematol.2019.219048

Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells (2041 Online Views)

Inge Baas, Laura Delvasto-Nuñez, Peter Ligthart, Conny Brouwer, Claudia Folman, Edimara S. Reis, Daniel Ricklin, John D. Lambris, Diana Wouters, Masja de Haas, Ilse Jongerius, Sacha S. Zeerleder

https://doi.org/10.3324/haematol.2019.216028

Targetable driver mutations in multicentric reticulohistiocytosis (1618 Online Views)

Norihiro Murakami, Tomohisa Sakai, Eisuke Arai, Hideki Muramatsu, Daisuke Ichikawa, Shuji Asai, Yoshie Shimoyama, Naoki Ishiguro, Yoshiyuki Takahashi, Yusuke Okuno, Yoshihiro Nishida

https://doi.org/10.3324/haematol.2019.218735

Platelet activation and multidrug resistance protein-4 expression in children and adolescents with different subtypes of primary thrombocythemia (564 Online Views)

Fiorina Giona, Isabella Massimi, Maria Luisa Guarino, Michelina Santopietro, Marica Laurino, Flavia Temperilli, Giovanna Palumbo, Robin Foà, Fabio Maria Pulcinelli

https://doi.org/10.3324/haematol.2019.226266

Variable global distribution of cell-of-origin from the ROBUST phase III study in diffuse large B-cell lymphoma (1233 Online Views)

Grzegorz S. Nowakowski, Annalisa Chiappella, Thomas E. Witzig, David W. Scott, Michele Spina, Randy D. Gascoyne, Lei Zhang, Jacqueline Russo, Janet Kang, Jingshan Zhang, Yingyong Xu, Umberto Vitolo

https://doi.org/10.3324/haematol.2019.220475

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma (2236 Online Views)

Thijs W.H. Flinsenberg, Charnelle C. Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin Y.T. Thia, Tahereh Noori, Xiaomin Song, Han X. Aw Yeang, Daniela G. Tantalo, Sasanka Handunnetti, John F. Seymour, Andrew W. Roberts, David Ritchie, Rachel Koldej, Paul J. Neeson, Lai Wang, Joseph A. Trapani, Constantine S. Tam, Ilia Voskoboinik

https://doi.org/10.3324/haematol.2019.220590

Preclinical evidence for an effective therapeutic activity of FL118, a novel survivin inhibitor, in patients with relapsed/refractory multiple myeloma (2343 Online Views)

Lisa C. Holthof, Hilma J. van der Horst, Susan E. van Hal-van Veen, Ruud W.J. Ruiter, Fengzhi Li, Marijke Buijze, Morten N. Andersen, Huipin Yuan, Joost de Bruijn, Niels W.C.J. van de Donk, Henk M. Lokhorst, Sonja Zweegman, Richard W.J. Groen, Tuna Mutis

https://doi.org/10.3324/haematol.2018.213314

Case Reports

Bone marrow findings in Erdheim-Chester disease: increased prevalence of chronic myeloid neoplasms (1214 Online Views)

Gaurav Goyal, Aishwarya Ravindran, Yuanhang Liu, Rong He, Mithun V. Shah, N. Nora Bennani, Mrinal M. Patnaik, Karen L. Rech, Ronald S. Go

https://doi.org/10.3324/haematol.2019.234187