March, 2020
No. 105 (3)

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Editorials

Perspective Articles

Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal

Swee Lay Thein, France Pirenne, Ross M. Fasano, Anoosha Habibi, Pablo Bartolucci, Satheesh Chonat, Jeanne E. Hendrickson, Sean R. Stowell

https://doi.org/10.3324/haematol.2019.224709

Centenary Review

Review Articles

An international registry of patients with plasminogen deficiency (HISTORY)

Amy D. Shapiro, Marzia Menegatti, Roberta Palla, Marco Boscarino, Christopher Roberson, Paolo Lanzi, Joel Bowen, Charles Nakar, Isaac A. Janson, Flora Peyvandi

https://doi.org/10.3324/haematol.2019.241158

Articles

Hematopoiesis

Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance

Cuiping Zhang, Yvonne N Fondufe-Mittendorf, Chi Wang, Jin Chen, Qiang Cheng, Daohong Zhou, Yi Zheng, Hartmut Geiger, Ying Liang

https://doi.org/10.3324/haematol.2018.207092

Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis

Giovanny Hernandez, Taylor S. Mills, Jennifer L. Rabe, James S. Chavez, Susan Kuldanek, Gregory Kirkpatrick, Leila Noetzli, Widian K. Jubair, Michelle Zanche, Jason R. Myers, Brett M. Stevens, Courtney J. Fleenor, Biniam Adane, Charles A. Dinarello, John Ashton, Craig T. Jordan, Jorge Di Paola, James R. Hagman, V. Michael Holers, Kristine A. Kuhn, Eric M. Pietras

https://doi.org/10.3324/haematol.2018.197210

Bone Marrow Failure

CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients

Masoud Nasri, Malte Ritter, Perihan Mir, Benjamin Dannenmann, Narges Aghaallaei, Diana Amend, Vahagn Makaryan, Yun Xu, Breanna Fletcher, Regine Bernhard, Ingeborg Steiert, Karin Hahnel, Jürgen Berger, Iris Koch, Brigitte Sailer, Katharina Hipp, Cornelia Zeidler, Maksim Klimiankou, Baubak Bajoghli, David C. Dale, Karl Welte, Julia Skokowa

https://doi.org/10.3324/haematol.2019.221804

Red Cell Biology & Its Disorders

PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells

Alexis Caulier, Nicolas Jankovsky, Yohann Demont, Hakim Ouled-Haddou, Julien Demagny, Corinne Guitton, Lavinia Merlusca, Delphine Lebon, Pascal Vong, Aurélien Aubry, Agnès Lahary, Christian Rose, Sandrine Gréaume, Emilie Cardon, Jessica Platon, Halima Ouadid-Ahidouch, Jacques Rochette, Jean-Pierre Marolleau, Véronique Picard, Loïc Garçon

https://doi.org/10.3324/haematol.2019.218503

A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease

James G. McArthur, Niels Svenstrup, Chunsheng Chen, Aurelie Fricot, Caroline Carvalho, Julia Nguyen, Phong Nguyen, Anna Parachikova, Fuad Abdulla, Gregory M. Vercellotti, Olivier Hermine, Dave Edwards, Jean-Antoine Ribeil, John D. Belcher, Thiago T. Maciel

https://doi.org/10.3324/haematol.2018.213462

Myelodysplastic Syndromes

Impact of red blood cell transfusion dose density on progression-free survival in patients with lower-risk myelodysplastic syndromes

Louise de Swart, Simon Crouch, Marlijn Hoeks, Alex Smith, Saskia Langemeijer, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermâk, Eva Hellström-Lindberg, Reinhard Stauder, Guillermo Sanz, Moshe Mittelman, Mette Skov Holm, Luca Malcovati, Krzysztof Mądry, Ulrich Germing, Aurelia Tatic, Aleksandar Savic, Antonio Medina Almeida, Njetocka Gredelj-Simec, Agnes Guerci-Bresler, Odile Beyne-Rauzy, Dominic Culligan, Ioannis Kotsianidis, Raphael Itzykson, Corine van Marrewijk, Nicole Blijlevens, David Bowen, Theo de Witte, on behalf of the EUMDS Registry Participants

https://doi.org/10.3324/haematol.2018.212217

Impact of treatment with iron chelation therapy in patients with lower-risk myelodysplastic syndromes participating in the European MDS registry

Marlijn Hoeks, Ge Yu, Saskia Langemeijer, Simon Crouch, Louise de Swart, Pierre Fenaux, Argiris Symeonidis, Jaroslav Čermák, Eva Hellström-Lindberg, Guillermo Sanz, Reinhard Stauder, Mette Skov Holm, Moshe Mittelman, Krzysztof Mądry, Luca Malcovati, Aurelia Tatic, Antonio Medina Almeida, Ulrich Germing, Aleksandar Savic, Njetočka Gredelj Šimec, Dominic Culligan, Raphael Itzykson, Agnes Guerci-Bresler, Borhane Slama, Jackie Droste, Corine van Marrewijk, Arjan van de Loosdrecht, Nicole Blijlevens, Marian van Kraaij, David Bowen, Theo de Witte, Alex Smith, on behalf of the EUMDS Registry Participants

https://doi.org/10.3324/haematol.2018.212332

Myelodysplastic/Myeloproliferative Neoplasms

Impact of clinical, cytogenetic, and molecular profiles on long-term survival after transplantation in patients with chronic myelomonocytic leukemia

Janghee Woo, Dae Ro Choi, Barry E. Storer, Cecilia Yeung, Anna B. Halpern, Rachel B. Salit, Mohamed L. Sorror, David W. Woolston, Tim Monahan, Bart L. Scott, H. Joachim Deeg

https://doi.org/10.3324/haematol.2019.218677

Myeloproliferative Neoplasms

Multilevel defects in the hematopoietic niche in essential thrombocythemia

Ting Sun, Mankai Ju, Xinyue Dai, Huan Dong, Wenjing Gu, Yuchen Gao, Rongfeng Fu, Xiaofan Liu, Yueting Huang, Wei Liu, Ying Ch, Wentian Wang, Huiyuan Li, Yuan Zhou, Lihong Shi, Renchi Yang, Lei Zhang

https://doi.org/10.3324/haematol.2018.213686

Chronic Myeloid Leukemia

Human BCR/ABL1 induces chronic myeloid leukemia-like disease in zebrafish

Mengchang Xu, Yin Ye, Zhi’an Ye, Song’en Xu, Wei Liu, Jin Xu, Yiyue Zhang, Qifa Liu, Zhibin Huang, Wenqing Zhang

https://doi.org/10.3324/haematol.2019.215939

Acute Myeloid Leukemia

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su-Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran, Shantu Amin, David Claxton, Arati Sharma

https://doi.org/10.3324/haematol.2018.212886

Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

Lina Han, Qi Zhang, Monique Dail, Ce Shi, Antonio Cavazos, Vivian R. Ruvolo, Yang Zhao, Eugene Kim, Mohamed Rahmani, Duncan H. Mak, Sha S. Jin, Jun Chen, Darren C. Phillips, Paul Bottecelli Koller, Rodrigo Jacamo, Jared K. Burks, Courtney DiNardo, Naval Daver, Elias Jabbour, Jing Wang, Hagop M. Kantarjian, Michael Andreeff, Steven Grant, Joel D. Leverson, Deepak Sampath, Marina Konopleva

https://doi.org/10.3324/haematol.2018.205534

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

Heikki Kuusanmäki, Aino-Maija Leppä, Petri Pölönen, Mika Kontro, Olli Dufva, Debashish Deb, Bhagwan Yadav, Oscar Brück, Ashwini Kumar, Hele Everaus, Bjørn T. Gjertsen, Merja Heinäniemi, Kimmo Porkka, Satu Mustjoki, Caroline A. Heckman

https://doi.org/10.3324/haematol.2018.214882

Mutations associated with a 17-gene leukemia stem cell score and the score’s prognostic relevance in the context of the European LeukemiaNet classification of acute myeloid leukemia

Marius Bill, Deedra Nicolet, Jessica Kohlschmidt, Christopher J. Walker, Krzysztof Mrózek, Ann-Kathrin Eisfeld, Dimitrios Papaioannou, Xiaoqing Rong-Mullins, Zachary Brannan, Jonathan E. Kolitz, Bayard L. Powell, Kellie J. Archer, Adrienne M. Dorrance, Andrew J. Carroll, Richard M. Stone, John C. Byrd, Ramiro Garzon, Clara D. Bloomfield

https://doi.org/10.3324/haematol.2019.225003

Non-Hodgkin Lymphoma

CDCA7 finely tunes cytoskeleton dynamics to promote lymphoma migration and invasion

Carla Martín-Cortázar, Yuri Chiodo, Raul P. Jiménez, Manuel Bernabé, María Luisa Cayuela, Teresa Iglesias, Miguel R. Campanero

https://doi.org/10.3324/haematol.2018.215459

A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models

Aïda Falgàs, Victor Pallarès, Ugutz Unzueta, María Virtudes Céspedes, Irene Arroyo-Solera, María José Moreno, Jorge Sierra, Alberto Gallardo, María Antonia Mangues, Esther Vázquez, Antonio Villaverde, Ramon Mangues, Isolda Casanova

https://doi.org/10.3324/haematol.2018.211490

Chronic Lymphocytic Leukemia

Clinical characteristics and outcomes of Richter transformation: experience of 204 patients from a single center

Yucai Wang, Marcella A. Tschautscher, Kari G. Rabe, Timothy G. Call, Jose F. Leis, Saad S. Kenderian, Neil E. Kay, Eli Muchtar, Daniel L. Van Dyke, Amber B. Koehler, Susan M. Schwager, Susan L. Slager, Sameer A. Parikh, Wei Ding

https://doi.org/10.3324/haematol.2019.224121

Plasma Cell Disorders

The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation

Fabrice Chatonnet, Amandine Pignarre, Aurélien A. Sérandour, Gersende Caron, Stéphane Avner, Nicolas Robert, Alboukadel Kassambara, Audrey Laurent, Maud Bizot, Xabier Agirre, Felipe Prosper, José I. Martin-Subero, Jérôme Moreaux, Thierry Fest, Gilles Salbert

https://doi.org/10.3324/haematol.2019.222133

Kinome expression profiling to target new therapeutic avenues in multiple myeloma

Hugues de Boussac, Angélique Bruyer, Michel Jourdan, Anke Maes, Nicolas Robert, Claire Gourzones, Laure Vincent, Anja Seckinger, Guillaume Cartron, Dirk Hose, Elke De Bruyne, Alboukadel Kassambara, Philippe Pasero, Jérôme Moreaux

https://doi.org/10.3324/haematol.2018.208306

Cell Therapy & Immunotherapy

Long-term eradication of extranodal natural killer/T-cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo

Miki Ando, Jun Ando, Satoshi Yamazaki, Midori Ishii, Yumi Sakiyama, Sakiko Harada, Tadahiro Honda, Tomoyuki Yamaguchi, Masanori Nojima, Koichi Ohshima, Hiromitsu Nakauchi, Norio Komatsu

https://doi.org/10.3324/haematol.2019.223511

Platelet Biology & its Disorders

Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A

Martin Berger, Zaher Raslan, Ahmed Aburima, Simbarashe Magwenzi, Katie S. Wraith, Benjamin E.J. Spurgeon, Matthew S. Hindle, Robert Law, Maria Febbraio, Khalid M. Naseem

https://doi.org/10.3324/haematol.2018.213348

Eltrombopag for the treatment of inherited thrombocytopenias: a phase II clinical trial

Carlo Zaninetti, Paolo Gresele, Antonella Bertomoro, Catherine Klersy, Erica De Candia, Dino Veneri, Serena Barozzi, Tiziana Fierro, Maria Adele Alberelli, Valeria Musella, Patrizia Noris, Fabrizio Fabris, Carlo L. Balduini, Alessandro Pecci

https://doi.org/10.3324/haematol.2019.223966

Coagulation & Its Disorders

Next-generation sequencing and recombinant expression characterized aberrant splicing mechanisms and provided correction strategies in factor VII deficiency

Paolo Ferraresi, Dario Balestra, Caroline Guittard, Delphine Buthiau, Brigitte Pan-Petesh, Iva Maestri, Roula Farah, Mirko Pinotti, Muriel Giansily-Blaizot

https://doi.org/10.3324/haematol.2019.217539

Errata Corrige

Acute Lymphoblastic Leukemia

Online Only Articles

Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit

Victor R. Gordeuk, Galina Y. Miasnikova, Adelina I. Sergueeva, Felipe R. Lorenzo, Xu Zhang, Jihyun Song, David W. Stockton, Josef T. Prchal

https://doi.org/10.3324/haematol.2019.216267

Mathematical modeling reveals alternative JAK inhibitor treatment in myeloproliferative neoplasms

Kaitlyn Shank, Andrew Dunbar, Priya Koppikar, Maria Kleppe, Julie Teruya-Feldstein, Isabelle Csete, Neha Bhagwat, Matthew Keller, Outi Kilpivaara, Franziska Michor, Ross L. Levine, Laura de Vargas Roditi

https://doi.org/10.3324/haematol.2018.203729

Masked polycythemia vera: analysis of a single center cohort of 2480 red cell masses

Nabih Maslah, Juliette Soret, Christine Dosquet, Laetitia Vercellino, Célia Belkhodja, Marie-Hélène Schlageter, Bruno Cassinat, Jean-Jacques Kiladjian, Christine Chomienne, Stephane Giraudier

https://doi.org/10.3324/haematol.2018.215582

Genomics of therapy-related myeloid neoplasms

Teodora Kuzmanovic, Bhumika J. Patel, Srinivasa R. Sanikommu, Yasunobu Nagata, Hassan Awada, Cassandra M. Kerr, Bartlomiej P. Przychodzen, Babal K. Jha, Devendra Hiwase, Deepak Singhal, Anjali S. Advani, Aziz Nazha, Aaron T. Gerds, Hetty E. Carraway, Mikkael A. Sekeres, Sudipto Mukherjee, Jaroslaw P. Maciejewski, Tomas Radivoyevitch

https://doi.org/10.3324/haematol.2019.219352

Progression of progenitor B-cell leukemia is associated with alterations of the bone marrow micro-environment

Josefine Åhsberg, Pingnan Xiao, Kazuki Okuyama, Rajesh Somasundaram, Tobias Strid, Hong Qian, Mikael Sigvardsson

https://doi.org/10.3324/haematol.2018.214031

Genomic and outcome analysis of adult T-cell lymphoblastic lymphoma

Zhaoming Li, Yue Song, Yanjie Zhang, Chaoping Li, Yingjun Wang, Weili Xue, Lisha Lu, Mengyuan Jin, Zhiyuan Zhou, Xinhua Wang, Ling Li, Lei Zhang, Xin Li, Xiaorui Fu, Zhenchang Sun, Jingjing Wu, Xudong Zhang, Hui Yu, Feifei Nan, Yu Chang, Jiaqin Yan, Xiaoyan Feng, Xiaolong Wu, Guannan Wang, Dandan Zhang, Wencai Li, Feixiang Li, Yuan Zhang, Ken H. Young, Mingzhi Zhang

https://doi.org/10.3324/haematol.2019.220863

Osteolytic disease in IL-6 and Myc dependent mouse model of human myeloma

Fumou Sun, Yan Cheng, Susan A. Walsh, Michael R. Acevedo, Xuefang Jing, Seong Su Han, Michael D. Pisano, Michael H. Tomasson, Alan K. Lichtenstein, Fenghuang Zhan, Parameswaran Hari, Siegfried Janz

https://doi.org/10.3324/haematol.2019.221127

Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma

Esperanza M Algarín, Andrea Díaz-Tejedor, Pedro Mogollón, Susana Hernández-García, Luis A. Corchete, Laura San-Segundo, Montserrat Martín-Sánchez, Lorena González-Méndez, Marie Schoumacher, Sebastien Banquet, Laurence Kraus-Berthier, Ioana Kloos, Alix Derreal, Ensar Halilovic, Heiko Maacke, Norma C. Gutiérrez, María-Victoria Mateos, Teresa Paíno, Mercedes Garayoa, Enrique M. Ocio

https://doi.org/10.3324/haematol.2018.212308

High-throughput platelet spreading analysis: a tool for the diagnosis of platelet-based bleeding disorders

Abdullah O. Khan, Annabel Maclachlan, Gillian C. Lowe, Phillip L.R. Nicolson, Rashid Al Ghaithi, Steven G. Thomas, Steve P. Watson, Jeremy A. Pike, Neil V. Morgan

https://doi.org/10.3324/haematol.2019.225912

Endocytosis by macrophages: interplay of macrophage scavenger receptor-1 and LDL receptor-related protein-1

Eelke P. Béguin, Małgorzata A. Przeradzka, Esmée F.J. Janssen, Henriët Meems, Magdalena Sedek, Carmen van der Zwaan, Koen Mertens, Maartje van den Biggelaar, Alexander B. Meijer, Marjon J. Mourik

https://doi.org/10.3324/haematol.2018.210682

Case Reports