January, 2019
No. 104 (1)

Editorials

Review Articles

Articles

Hematopoiesis

The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells

Deborah Ingenhag, Sven Reister, Franziska Auer, Sanil Bhatia, Sarah Wildenhain, Daniel Picard, Marc Remke, Jessica I. Hoell, Andreas Kloetgen, Dennis Sohn, Reiner U. Jänicke, Gesine Koegler, Arndt Borkhardt, Julia Hauer

https://doi.org/10.3324/haematol.2018.189407

Cell Therapy & Immunotherapy

Acute Myeloid Leukemia

2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia

Ying Lu, Jin-Song Yan, Li Xia, Kang Qin, Qian-Qian Yin, Hong-Tao Xu, Meng-Qing Gao, Xiao-Ning Qu, Yu-Ting Sun, Guo-Qiang Chen

https://doi.org/10.3324/haematol.2018.191916

Gemtuzumab ozogamicin for de novo acute myeloid leukemia: final efficacy and safety updates from the open-label, phase III ALFA-0701 trial

Juliette Lambert, Cécile Pautas, Christine Terré, Emmanuel Raffoux, Pascal Turlure, Denis Caillot, Ollivier Legrand, Xavier Thomas, Claude Gardin, Karïn Gogat-Marchant, Stephen D. Rubin, Rebecca J. Benner, Pierre Bousset, Claude Preudhomme, Sylvie Chevret, Herve Dombret, Sylvie Castaigne

https://doi.org/10.3324/haematol.2018.188888

Gemtuzumab ozogamicin in children with relapsed or refractory acute myeloid leukemia: a report by Berlin-Frankfurt-Münster study group

Naghmeh Niktoreh, Beate Lerius, Martin Zimmermann, Bernd Gruhn, Gabriele Escherich, Jean-Pierre Bourquin, Michael Dworzak, Lucie Sramkova, Claudia Rossig, Ursula Creutzig, Dirk Reinhardt, Mareike Rasche

https://doi.org/10.3324/haematol.2018.191841

Acute Lymphoblastic Leukemia

Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion

Kentaro Ohki, Nobutaka Kiyokawa, Yuya Saito, Shinsuke Hirabayashi, Kazuhiko Nakabayashi, Hitoshi Ichikawa, Yukihide Momozawa, Kohji Okamura, Ai Yoshimi, Hiroko Ogata-Kawata, Hiromi Sakamoto, Motohiro Kato, Keitaro Fukushima, Daisuke Hasegawa, Hiroko Fukushima, Masako Imai, Ryosuke Kajiwara, Takashi Koike, Isao Komori, Atsushi Matsui, Makiko Mori, Koichi Moriwaki, Yasushi Noguchi, Myoung-ja Park, Takahiro Ueda, Shohei Yamamoto, Koichi Matsuda, Teruhiko Yoshida, Kenji Matsumoto, Kenichiro Hata, Michiaki Kubo, Yoichi Matsubara, Hiroyuki Takahashi, Takashi Fukushima, Yasuhide Hayashi, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara, for the Tokyo Children’s Cancer Study Group (TCCSG)

https://doi.org/10.3324/haematol.2017.186320

Non-Hodgkin Lymphoma

A phase 2 study of rituximab, bendamustine, bortezomib and dexamethasone for first-line treatment of older patients with mantle cell lymphoma

Rémy Gressin, Nicolas Daguindau, Adrian Tempescul, Anne Moreau, Sylvain Carras, Emmanuelle Tchernonog, Anna Schmitt, Roch Houot, Caroline Dartigeas, Jean Michel Pignon, Selim Corm, Anne Banos, Christiane Mounier, Jehan Dupuis, Margaret Macro, Joel Fleury, Fabrice Jardin, Clementine Sarkozy, Ghandi Damaj, Pierre Feugier, Luc Matthieu Fornecker, Cecile Chabrot, Veronique Dorvaux, Krimo Bouadallah, Sandy Amorin, Reda Garidi, Laurent Voillat, Bertrand Joly, Philippe Solal Celigny, Nadine Morineau, Marie Pierre Moles, Hacene Zerazhi, Jean Fontan, Yazid Arkam, Magda Alexis, Vincent Delwail, Jean Pierre Vilque, Loic Ysebaert, Steven Le Gouill, Mary B. Callanan, for the Lymphoma Study Association

https://doi.org/10.3324/haematol.2018.191429

Chronic Lymphocytic Leukemia

Feasibility and efficacy of addition of individualized-dose lenalidomide to chlorambucil and rituximab as first-line treatment in elderly and FCR-unfit patients with advanced chronic lymphocytic leukemia

Arnon P. Kater, Marinus H.J. van Oers, Yvette van Norden, Lina van der Straten, Julia Driessen, Ward F.M. Posthuma, Martin Schipperus, Martine E.D. Chamuleau, Marcel Nijland, Jeanette K. Doorduijn, Michel Van Gelder, Mels Hoogendoorn, Francien De Croon, Shulamiet Wittebol, J. Martijn Kerst, Erik W.A. Marijt, Reinier A.P. Raymakers, Martijn R. Schaafsma, Johan A. Dobber, Sabina Kersting, Mark-David Levin

https://doi.org/10.3324/haematol.2018.193854

Plasma Cell Disorders

DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling

Kazuya Ishiguro, Hiroshi Kitajima, Takeshi Niinuma, Tadao Ishida, Reo Maruyama, Hiroshi Ikeda, Toshiaki Hayashi, Hajime Sasaki, Hideki Wakasugi, Koyo Nishiyama, Tetsuya Shindo, Eiichiro Yamamoto, Masahiro Kai, Yasushi Sasaki, Takashi Tokino, Hiroshi Nakase, Hiromu Suzuki

https://doi.org/10.3324/haematol.2018.191262

Platelet Biology & its Disorders

Clinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpura

Elizabeth M. Staley, Wenjing Cao, Huy P. Pham, Chong H. Kim, Nicole K. Kocher, Lucy Zheng, Radhika Gangaraju, Robin G. Lorenz, Lance A. Williams, Marisa B. Marques, X. Long Zheng

https://doi.org/10.3324/haematol.2018.198275

Coagulation & Its Disorders

Computed tomography pulmonary angiography versus ventilation-perfusion lung scanning for diagnosing pulmonary embolism during pregnancy: a systematic review and meta-analysis

Cécile Tromeur, Liselotte M. van der Pol, Pierre-Yves Le Roux, Yvonne Ende-Verhaar, Pierre-Yves Salaun, Christophe Leroyer, Francis Couturaud, Lucia J.M. Kroft, Menno V. Huisman, Frederikus A. Klok

https://doi.org/10.3324/haematol.2018.196121

Stem Cell Transplantation

Machine learning reveals chronic graft-versus-host disease phenotypes and stratifies survival after stem cell transplant for hematologic malignancies

Jocelyn S. Gandelman, Michael T. Byrne, Akshitkumar M. Mistry, Hannah G. Polikowsky, Kirsten E. Diggins, Heidi Chen, Stephanie J. Lee, Mukta Arora, Corey Cutler, Mary Flowers, Joseph Pidala, Jonathan M. Irish, Madan H. Jagasia

https://doi.org/10.3324/haematol.2018.193441

Blood Transfusion

Cold storage of platelets in additive solution: the impact of residual plasma in apheresis platelet concentrates

Irene Marini, Konstanze Aurich, Rabie Jouni, Stefanie Nowak-Harnau, Oliver Hartwich, Andreas Greinacher, Thomas Thiele, Tamam Bakchoul

https://doi.org/10.3324/haematol.2018.195057

Iron Metabolism & Its Disorders

Macrophage ferroportin is essential for stromal cell proliferation in wound healing

Stefania Recalcati, Elena Gammella, Paolo Buratti, Andrea Doni, Achille Anselmo, Massimo Locati, Gaetano Cairo

https://doi.org/10.3324/haematol.2018.197517

Myelodysplastic Syndromes

Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outcome

Julia Stomper, Gabriele Ihorst, Stefan Suciu, Philipp N. Sander, Heiko Becker, Pierre W. Wijermans, Christoph Plass, Dieter Weichenhan, Emmanuel Bissé, Rainer Claus, Michael Lübbert

https://doi.org/10.3324/haematol.2017.187278

Myeloproliferative Neoplasms

Vascular endothelial cell expression of JAK2V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

Alexandre Guy, Virginie Gourdou-Latyszenok, Nicolas Le Lay, Claire Peghaire, Badr Kilani, Juliana Vieira Dias, Cécile Duplaa, Marie-Ange Renault, Cécile Denis, Jean Luc Villeval, Yacine Boulaftali, Martine Jandrot-Perrus, Thierry Couffinhal, Chloe James

https://doi.org/10.3324/haematol.2018.195321

Chronic Myeloid Leukemia

Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia

Timothy P. Hughes, Pierre Laneuville, Philippe Rousselot, David S. Snyder, Delphine Rea, Neil P. Shah, David Paar, Elisabetta Abruzzese, Andreas Hochhaus, Jeffrey H. Lipton, Jorge E. Cortes

https://doi.org/10.3324/haematol.2018.188987

Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells

Manuela Spagnuolo, Giulia Regazzo, Marco De Dominici, Andrea Sacconi, Andrea Pelosi, Etleva Korita, Francesco Marchesi, Francesco Pisani, Alessandra Magenta, Valentina Lulli, Iole Cordone, Andrea Mengarelli, Sabrina Strano, Giovanni Blandino, Maria G. Rizzo, Bruno Calabretta

https://doi.org/10.3324/haematol.2018.191213

Online Only Articles

Letters to the Editor

Intracardiac or intrapulmonary shunts were present in at least 35% of adults with homozygous sickle cell disease followed in an outpatient clinic

Bryan C. Hambley, Rania Abdul Rahman, Maxwell Reback, Mary Ann O’Riordan, Nathan Langer, Robert C. Gilkeson, Mahazarin Ginwalla, Jane A. Little, Robert Schilz

https://doi.org/10.3324/haematol.2018.196212

Long-term follow up of pediatric Philadelphia positive acute lymphoblastic leukemia treated with the EsPhALL2004 study: high white blood cell count at diagnosis is the strongest prognostic factor

Andrea Biondi, Gunnar Cario, Paola De Lorenzo, Anders Castor, Valentino Conter, Veronica Leoni, Virginie Gandemer, Rob Pieters, Jan Stary, Gabriele Escherich, Myriam Campbell, Andishe Attarbaschi, Chi-Kong Li, Ajay Vora, Jutta Bradtke, Vaskar Saha, Maria Grazia Valsecchi, Martin Schrappe

https://doi.org/10.3324/haematol.2018.199422

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

Renate De Smedt, Sofie Peirs, Julie Morscio, Filip Matthijssens, Juliette Roels, Lindy Reunes, Beatrice Lintermans, Steven Goossens, Tim Lammens, Nadine Van Roy, Aurore Touzart, Silvia Jenni, Yi-Chien Tsai, Federica Lovisa, Lara Mussolin, Valentina Serafin, Filip Van Nieuwerburgh, Dieter Deforce, Anne Uyttebroeck, Thomas Tousseyn, Birgit Burkhardt, Wolfram Klapper, Barbara De Moerloose, Yves Benoit, Elizabeth Macintyre, Jean-Pierre Bourquin, Giuseppe Basso, Benedetta Accordi, Beat Bornhauser, Jules Meijerink, Peter Vandenberghe, Pieter Van Vlierberghe

https://doi.org/10.3324/haematol.2018.199257

Programmed cell death protein-1 (PD-1)-expression in the microenvironment of classical Hodgkin lymphoma at relapse during anti-PD-1-treatment

Stephanie Sasse, Katharina Reddemann, Arjan Diepstra, Ilske Oschlies, Antje Schnitter, Sven Borchmann, Andreas Engert, Peter Borchmann, Wolfram Klapper

https://doi.org/10.3324/haematol.2018.196279

MYC protein expression scoring and its impact on the prognosis of aggressive B-cell lymphoma patients

Maria R. Ambrosio, Stefano Lazzi, Giuseppe Lo Bello, Raffaella Santi, Leonardo Del Porro, Maria M. de Santi, Raffaella Guazzo, Lucia Mundo, Luigi Rigacci, Sofia Kovalchuck, Noel Onyango, Alberto Fabbri, Emanuele Cencini, Pier Luigi Zinzani, Francesco Zaja, Francesco Angrilli, Caterina Stelitano, Maria G. Cabras, Giuseppe Spataro, Roshanak Bob, Thomas Menter, Massimo Granai, Gabriele Cevenini, Kikkeri N. Naresh, Harald Stein, Elena Sabattini, Lorenzo Leoncini

https://doi.org/10.3324/haematol.2018.195958

Incidence of upper-extremity deep vein thrombosis in western France: a community-based study

Aurélien Delluc, Raphaël Le Mao, Cécile Tromeur, Nathalie Chambry, Hélène Rault-Nagel, Luc Bressollette, Dominique Mottier, Francis Couturaud, Karine Lacut

https://doi.org/10.3324/haematol.2018.194951

Case Report

Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8

Veronika Kanderova, Hana Grombirikova, Irena Zentsova, Kamila Reblova, Adam Klocperk, Martina Fejtkova, Marketa Bloomfield, Barbora Ravcukova, Tomas Kalina, Tomas Freiberger, Anna Sediva

https://doi.org/10.3324/haematol.2018.201673

B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene

Mari Kubota-Tanaka, Tomoo Osumi, Shouko Miura, Hiroshi Tsujimoto, Toshihiko Imamura, Akira Nishimura, Kentaro Oki, Kozue Nakamura, Satoshi Miyamoto, Kento Inoue, Maiko Inoue, Takahiro Kamiya, Masakatsu Yanagimachi, Tsubasa Okano, Noriko Mitsuiki, Takeshi Isoda, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio, Shinji Kounami, Mikiya Endo, Motohiro Kato, Masatoshi Takagi

https://doi.org/10.3324/haematol.2018.199885

Spatial clonal evolution leading to ibrutinib resistance and disease progression in chronic lymphocytic leukemia

Richárd Kiss, Donát Alpár, Ambrus Gángó, Noémi Nagy, Ediz Eyupoglu, Dóra Aczél, András Matolcsy, Judit Csomor, Zoltán Mátrai, Csaba Bödör

https://doi.org/10.3324/haematol.2018.202085

Letters to the Editor

Effects of erythropoiesis-stimulating agents on overall survival of International Prognostic Scoring System Low/Intermediate-1 risk, transfusion-independent myelodysplastic syndrome patients: a cohort study

Emanuela Messa, Daniela Gioia, Elisa Masiera, Anna Castiglione, Manuela Ceccarelli, Flavia Salvi, Paolo Danise, Alessandro Sanna, Bernardino Allione, Enrico Balleari, Antonella Poloni, Giovanni Cametti, Dario Ferrero, Rodolfo Tassara, Carlo Finelli, Margherita Bonferroni, Pellegrino Musto, Giuseppe Saglio, Alessandro Levis, Valeria Santini

https://doi.org/10.3324/haematol.2017.183590

Comment

Letters to the Editor

Impact of FLT3-ITD length on prognosis of acute myeloid leukemia

Song-Bai Liu, Hao-Jie Dong, Xie-Bing Bao, Qiao-Cheng Qiu, Hong-Zhi Li, Hong-Jie Shen, Zi-Xuan Ding, Chao Wang, Xiao-Ling Chu, Jing-Qiu Yu, Tao Tao, Zheng Li, Xiao-Wen Tang, Su-Ning Chen, De-Pei Wu, Ling Li, Sheng-Li Xue

https://doi.org/10.3324/haematol.2018.191809