December, 2018
No. 103 (12)

Editorials

Review Articles

TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics

Elias Campo, Florence Cymbalista, Paolo Ghia, Ulrich Jäger, Sarka Pospisilova, Richard Rosenquist, Anna Schuh, Stephan Stilgenbauer

https://doi.org/10.3324/haematol.2018.187583

Articles

Hematopoiesis

Niche TWIST1 is critical for maintaining normal hematopoiesis and impeding leukemia progression

Xiaoyan Liu, Yanping Ma, Rongrong Li, Dan Guo, Nan Wang, Yangyang Zhao, Jing Yin, Qian Ren, Yongmin Lin, Xiaotong Ma

https://doi.org/10.3324/haematol.2018.190652

ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion

Vikas Madan, Lin Han, Norimichi Hattori, Weoi Woon Teoh, Anand Mayakonda, Qiao-Yang Sun, Ling-Wen Ding, Hazimah Binte Mohd Nordin, Su Lin Lim, Pavithra Shyamsunder, Pushkar Dakle, Janani Sundaresan, Ngan B. Doan, Masashi Sanada, Aiko Sato-Otsubo, Manja Meggendorfer, Henry Yang, Jonathan W. Said, Seishi Ogawa, Torsten Haferlach, Der-Cherng Liang, Lee-Yung Shih, Tsuyoshi Nakamaki, Q. Tian Wang, H. Phillip Koeffler

https://doi.org/10.3324/haematol.2018.189928

Iron Metabolism & Its Disorders

Optimizing diagnostic biomarkers of iron deficiency anemia in community-dwelling Indian women and preschool children

Giridhar Kanuri, Deepti Chichula, Ritica Sawhney, Kevin Kuriakose, Sherwin De’Souza, Faye Pais, Karthika Arumugam, Arun S. Shet

https://doi.org/10.3324/haematol.2018.193243

Red Cell Biology & Its Disorders

Non-muscle myosin II drives vesicle loss during human reticulocyte maturation

Pedro L. Moura, Bethan R. Hawley, Tosti J. Mankelow, Rebecca E. Griffiths, Johannes G.G. Dobbe, Geert J. Streekstra, David J. Anstee, Timothy J. Satchwell, Ashley M. Toye

https://doi.org/10.3324/haematol.2018.199083

The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2

Lisa G. Riley, Matthew M. Heeney, Joëlle Rudinger-Thirion, Magali Frugier, Dean R. Campagna, Ronghao Zhou, Gregory A. Hale, Lee M. Hilliard, Joel A. Kaplan, Janet L. Kwiatkowski, Colin A. Sieff, David P. Steensma, Alexander J. Rennings, Annet Simons, Nicolaas Schaap, Richard J. Roodenburg, Tjitske Kleefstra, Leonor Arenillas, Josep Fita-Torró, Rasha Ahmed, Miguel Abboud, Elie Bechara, Roula Farah, Rienk Y. J. Tamminga, Sylvia S. Bottomley, Mayka Sanchez, Gerwin Huls, Dorine W. Swinkels, John Christodoulou, Mark D. Fleming

https://doi.org/10.3324/haematol.2017.182659

Chronic Myeloid Leukemia

BCR-ABL1 mediated miR-150 downregulation through MYC contributed to myeloid differentiation block and drug resistance in chronic myeloid leukemia

Klara Srutova, Nikola Curik, Pavel Burda, Filipp Savvulidi, Giovannino Silvestri, Rossana Trotta, Hana Klamova, Pavla Pecherkova, Zofie Sovova, Jitka Koblihova, Tomas Stopka, Danilo Perrotti, Katerina Machova Polakova

https://doi.org/10.3324/haematol.2018.193086

BCR-ABL1 genomic DNA PCR response kinetics during first-line imatinib treatment of chronic myeloid leukemia

Ilaria S. Pagani, Phuong Dang, Ivar O. Kommers, Jarrad M. Goyne, Mario Nicola, Verity A. Saunders, Jodi Braley, Deborah L. White, David T. Yeung, Susan Branford, Timothy P. Hughes, David M. Ross

https://doi.org/10.3324/haematol.2018.189787

Acute Myeloid Leukemia

Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group

Lionel Adès, Xavier Thomas, Agnes Guerci Bresler, Emmanuel Raffoux, Olivier Spertini, Norbert Vey, Tony Marchand, Christian Récher, Arnaud Pigneux, Stephane Girault, Eric Deconinck, Claude Gardin, Olivier Tournilhac, Jean Francois Lambert, Patrice Chevallier, Stephane de Botton, Julie Lejeune, Hervé Dombret, Sylvie Chevret, Pierre Fenaux

https://doi.org/10.3324/haematol.2018.198614

Physician uncertainty aversion impacts medical decision making for older patients with acute myeloid leukemia: results of a national survey

Pierre Bories, Sébastien Lamy, Célestine Simand, Sarah Bertoli, Cyrille Delpierre, Sandra Malak, Luc Fornecker, Stéphane Moreau, Christian Récher, Antoine Nebout

https://doi.org/10.3324/haematol.2018.192468

Non-Hodgkin Lymphoma

Bromodomain and extra-terminal domain inhibition modulates the expression of pathologically relevant microRNAs in diffuse large B-cell lymphoma

Afua A. Mensah, Luciano Cascione, Eugenio Gaudio, Chiara Tarantelli, Riccardo Bomben, Elena Bernasconi, Domenico Zito, Andrea Lampis, Jens C. Hahne, Andrea Rinaldi, Anastasios Stathis, Emanuele Zucca, Ivo Kwee, Valter Gattei, Nicola Valeri, Maria E Riveiro, Francesco Bertoni

https://doi.org/10.3324/haematol.2018.191684

Cyclin-dependent kinase 9 as a potential specific molecular target in NK-cell leukemia/lymphoma

Shiori Kinoshita, Takashi Ishida, Asahi Ito, Tomoko Narita, Ayako Masaki, Susumu Suzuki, Takashi Yoshida, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Norio Shimizu, Hiroshi Inagaki, Taruho Kuroda, Arne Scholz, Ryuzo Ueda, Takaomi Sanda, Shinsuke Iida

https://doi.org/10.3324/haematol.2018.191395

Chronic Lymphocytic Leukemia

Trisomy 12 chronic lymphocytic leukemia expresses a unique set of activated and targetable pathways

Lynne V. Abruzzo, Carmen D. Herling, George A. Calin, Christopher Oakes, Lynn L. Barron, Haley E. Banks, Vikram Katju, Michael J. Keating, Kevin R. Coombes

https://doi.org/10.3324/haematol.2018.190132

Plasma Cell Disorders

Daratumumab plus bortezomib and dexamethasone versus bortezomib and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of CASTOR

Andrew Spencer, Suzanne Lentzsch, Katja Weisel, Hervé Avet-Loiseau, Tomer M. Mark, Ivan Spicka, Tamas Masszi, Birgitta Lauri, Mark-David Levin, Alberto Bosi, Vania Hungria, Michele Cavo, Je-Jung Lee, Ajay K. Nooka, Hang Quach, Cindy Lee, Wolney Barreto, Paolo Corradini, Chang-Ki Min, Emma C. Scott, Asher A. Chanan-Khan, Noemi Horvath, Marcelo Capra, Meral Beksac, Roberto Ovilla, Jae-Cheol Jo, Ho-Jin Shin, Pieter Sonneveld, David Soong, Tineke Casneuf, Christopher Chiu, Himal Amin, Ming Qi, Piruntha Thiyagarajah, A. Kate Sasser, Jordan M. Schecter, Maria-Victoria Mateos

https://doi.org/10.3324/haematol.2018.194118

Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of POLLUX

Meletios A. Dimopoulos, Jesus San-Miguel, Andrew Belch, Darrell White, Lotfi Benboubker, Gordon Cook, Merav Leiba, James Morton, P. Joy Ho, Kihyun Kim, Naoki Takezako, Philippe Moreau, Jonathan L. Kaufman, Heather J. Sutherland, Marc Lalancette, Hila Magen, Shinsuke Iida, Jin Seok Kim, H. Miles Prince, Tara Cochrane, Albert Oriol, Nizar J. Bahlis, Ajai Chari, Lisa O’Rourke, Kaida Wu, Jordan M. Schecter, Tineke Casneuf, Christopher Chiu, David Soong, A. Kate Sasser, Nushmia Z. Khokhar, Hervé Avet-Loiseau, Saad Z. Usmani

https://doi.org/10.3324/haematol.2018.194282

Platelet Biology & its Disorders

Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI

Phillip L.R. Nicolson, Craig E. Hughes, Stephanie Watson, Sophie H. Nock, Alexander T. Hardy, Callum N. Watson, Samantha J. Montague, Hayley Clifford, Aarnoud P. Huissoon, Jean-Daniel Malcor, Mark R. Thomas, Alice Y. Pollitt, Michael G. Tomlinson, Guy Pratt, Steve P. Watson

https://doi.org/10.3324/haematol.2018.193391

Stem Cell Transplantation

Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regimen toxicity, and engraftment kinetics

Fatma Keklik, Ezzideen Barjes Alrawi, Qing Cao, Nelli Bejanyan, Armin Rashidi, Aleksandr Lazaryan, Patrick Arndt, Erhan H. Dincer, Veronika Bachanova, Erica D. Warlick, Margaret L. MacMillan, Mukta Arora, Jeffrey Miller, Claudio G Brunstein, Daniel J. Weisdorf, Celalettin Ustun

https://doi.org/10.3324/haematol.2018.189134

Online Only Articles

Recurrent heteroplasmy for the MT-ATP6 p.Ser148Asn (m.8969G>A) mutation in patients with syndromic congenital sideroblastic anemia of variable clinical severity

Simon Berhe, Matthew M. Heeney, Dean R. Campagna, John F. Thompson, Eric J. White, Tristen Ross, Roy W. A. Peake, Jeffery D. Hanrahan, Vilmarie Rodriguez, Deborah L. Renaud, Mrinal S. Patnaik, Eugenia Chang, Sylvia S. Bottomley, Mark D. Fleming

https://doi.org/10.3324/haematol.2018.199109

Sideroblastic anemia with myopathy secondary to novel, pathogenic missense variants in the YARS2 gene

Frances Smith, Sila Hopton, Cristina Dallabona, Micol Gilberti, Gavin Falkous, Fiona Norwood, Claudia Donnini, Gráinne S. Gorman, Barnaby Clark, Robert W. Taylor, Austin G. Kulasekararaj

https://doi.org/10.3324/haematol.2018.194464

A novel type of NPM1 mutation characterized by multiple internal tandem repeats in a case of cytogenetically normal acute myeloid leukemia

Nicolas Duployez, Lydia Chebrek, Nathalie Helevaut, Elise Fournier, Maxime Bemba, Aurélie Caillault, Sandrine Geffroy, Claude Preudhomme

https://doi.org/10.3324/haematol.2018.190959

Acute myeloid leukemia in very old patients

Vladimir Lj Lazarevic, Anders Bredberg, Fryderyk Lorenz, Emma Öhlander, Petar Antunovic, Jörg Cammenga, Lovisa Wennström, Lars Möllgård, Stefan Deneberg, Åsa Derolf, Martin Höglund, Gunnar Juliusson, for the Swedish AML Registry

https://doi.org/10.3324/haematol.2018.196691

Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load

Sebastian Vosberg, Luise Hartmann, Klaus H. Metzeler, Nikola P. Konstandin, Stephanie Schneider, Ashok Varadharajan, Andreas Hauser, Stefan Krebs, Helmut Blum, Stefan K. Bohlander, Wolfgang Hiddemann, Johanna Tischer, Karsten Spiekermann, Philipp A. Greif

https://doi.org/10.3324/haematol.2018.193102

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

Karen Verboom, Wouter Van Loocke, Pieter-Jan Volders, Bieke Decaesteker, Francisco Avila Cobos, Simon Bornschein, Charles E. de Bock, Zeynep Kalender Atak, Emmanuelle Clappier, Stein Aerts, Jan Cools, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jo Vandesompele, Frank Speleman, Kaat Durinck

https://doi.org/10.3324/haematol.2018.190587

Interim PET-directed therapy in limited-stage Hodgkin lymphoma initially treated with ABVD

Diego Villa, Laurie H. Sehn, Christina Aquino-Parsons, Petter Tonseth, David W. Scott, Alina S. Gerrie, Donald Wilson, François Bénard, Randy D. Gascoyne, Graham W. Slack, Pedro Farinha, James Morris, Tom Pickles, Joseph M. Connors, Kerry J. Savage

https://doi.org/10.3324/haematol.2018.196782

Impact of Sox11 over-expression in Ba/F3 cells

Martin Lord, Gustav Arvidsson, Agata M. Wasik, Birger Christensson, Anthony P. Wright, Alf Grandien, Birgitta Sander

https://doi.org/10.3324/haematol.2018.197467

Idelalisib impairs T-cell-mediated immunity in chronic lymphocytic leukemia

Silvia Martinelli, Rossana Maffei, Stefania Fiorcari, Chiara Quadrelli, Patrizia Zucchini, Stefania Benatti, Leonardo Potenza, Mario Luppi, Roberto Marasca

https://doi.org/10.3324/haematol.2017.187070

Treatment optimization for multiple myeloma: schedule-dependent synergistic cytotoxicity of pomalidomide and carfilzomib in in vitro and ex vivo models

Enrica Borsi, Marina Martello, Barbara Santacroce, Elena Zamagni, Paola Tacchetti, Lucia Pantani, Katia Mancuso, Serena Rocchi, Michele Cavo, Carolina Terragna

https://doi.org/10.3324/haematol.2017.186924

A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation

Alexandre Kauskot, Tiffany Pascreau, Frédéric Adam, Arnaud Bruneel, Christelle Reperant, Marc-Damien Lourenco-Rodrigues, Jean-Philippe Rosa, Rachel Petermann, Hélène Maurey, Claire Auditeau, Dominique Lasne, Cécile V. Denis, Marijke Bryckaert, Pascale de Lonlay, Cécile Lavenu-Bombled, Judith Melki, Delphine Borgel

https://doi.org/10.3324/haematol.2018.198028