February, 2019
No. 104 (2)

Editorials

Review Articles

CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies

Lucia Prieto-Torres, Socorro M. Rodriguez-Pinilla, Arantza Onaindia, Mariano Ara, Luis Requena, Miguel Á. Piris

https://doi.org/10.3324/haematol.2018.197152

Articles

Hematopoiesis

Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo

Xiaomin Wang, Yanan Gao, Juan Gao, Minghao Li, Mi Zhou, Jinhong Wang, Yakun Pang, Hui Cheng, Chase Yuan, Yajing Chu, Yu Jiang, Jianfeng Zhou, Hongbo R. Luo, Zhenyu Ju, Tao Cheng, Weiping Yuan

https://doi.org/10.3324/haematol.2018.194811

Bone Marrow Failure

Aplastic anemia in the elderly: a nationwide survey on behalf of the French Reference Center for Aplastic Anemia

Adrien Contejean, Matthieu Resche-Rigon, Jérôme Tamburini, Marion Alcantara, Fabrice Jardin, Etienne Lengliné, Lionel Adès, Didier Bouscary, Ambroise Marçais, Delphine Lebon, Cécile Chabrot, Louis Terriou, Fiorenza Barraco, Anne Banos, Lucile Bussot, Jean-Yves Cahn, Pierre Hirsch, Natacha Maillard, Laurence Simon, Luc-Matthieu Fornecker, Gerard Socié, Regis Peffault de Latour, Flore Sicre de Fontbrune

https://doi.org/10.3324/haematol.2018.198440

Red Cell Biology & Its Disorders

Exposure to non-inherited maternal antigens by breastfeeding affects antibody responsiveness

Henk Schonewille, Jon J. van Rood, Esther P. Verduin, Leo M.G. van de Watering, Geert W. Haasnoot, Frans H.J. Claas, Dick Oepkes, Enrico Lopriore, Anneke Brand

https://doi.org/10.3324/haematol.2018.199406

Phagocyte Biology & its Disorders

Treatment outcomes and prognostic factors in adult patients with secondary hemophagocytic lymphohistiocytosis not associated with malignancy

Jae-Ho Yoon, Sung-Soo Park, Young-Woo Jeon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Hee-Je Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Jong Wook Lee

https://doi.org/10.3324/haematol.2018.198655

Acute Myeloid Leukemia

Comprehensive genetic diagnosis of acute myeloid leukemia by next-generation sequencing

Elisabeth K.M. Mack, André Marquardt, Danny Langer, Petra Ross, Alfred Ultsch, Michael G. Kiehl, Hildegard I.D. Mack, Torsten Haferlach, Andreas Neubauer, Cornelia Brendel

https://doi.org/10.3324/haematol.2018.194258

A novel deep targeted sequencing method for minimal residual disease monitoring in acute myeloid leukemia

Esther Onecha, Maria Linares, Inmaculada Rapado, Yanira Ruiz-Heredia, Pilar Martinez-Sanchez, Teresa Cedena, Marta Pratcorona, Jaime Perez Oteyza, Pilar Herrera, Eva Barragan, Pau Montesinos, Jose Antonio Garcia Vela, Elena Magro, Eduardo Anguita, Angela Figuera, Rosalia Riaza, Pilar Martinez-Barranco, Beatriz Sanchez-Vega, Josep Nomdedeu, Miguel Gallardo, Joaquin Martinez-Lopez, Rosa Ayala

https://doi.org/10.3324/haematol.2018.194712

Targeted RNA-sequencing for the quantification of measurable residual disease in acute myeloid leukemia

Laura W. Dillon, Sheida Hayati, Gregory W. Roloff, Ilker Tunc, Mehdi Pirooznia, Antonina Mitrofanova, Christopher S. Hourigan

https://doi.org/10.3324/haematol.2018.203133

Persistent IDH1/2 mutations in remission can predict relapse in patients with acute myeloid leukemia

Chi Young Ok, Sanam Loghavi, Dawen Sui, Peng Wei, Rashmi Kanagal-Shamanna, C. Cameron Yin, Zhuang Zuo, Mark J. Routbort, Guilin Tang, Zhenya Tang, Jeffrey L. Jorgensen, Rajyalakshmi Luthra, Farhad Ravandi, Hagop M. Kantarjian, Courtney D. DiNardo, L. Jeffrey Medeiros, Sa A. Wang, Keyur P. Patel

https://doi.org/10.3324/haematol.2018.191148

Acute Lymphoblastic Leukemia

Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia

Anna Lucia Fedullo, Monica Messina, Loredana Elia, Alfonso Piciocchi, Valentina Gianfelici, Alessia Lauretti, Stefano Soddu, Maria Cristina Puzzolo, Clara Minotti, Felicetto Ferrara, Bruno Martino, Patrizia Chiusolo, Valeria Calafiore, Stefania Paolini, Marco Vignetti, Antonella Vitale, Anna Guarini, Robin Foà, Sabina Chiaretti

https://doi.org/10.3324/haematol.2018.196055

Non-Hodgkin Lymphoma

JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma

Bianca Schuhmacher, Julia Bein, Tobias Rausch, Vladimir Benes, Thomas Tousseyn, Martine Vornanen, Maurilio Ponzoni, Lorenz Thurner, Randy Gascoyne, Christian Steidl, Ralf Küppers, Martin-Leo Hansmann, Sylvia Hartmann

https://doi.org/10.3324/haematol.2018.203224

T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma

Suvi-Katri Leivonen, Marjukka Pollari, Oscar Brück, Teijo Pellinen, Matias Autio, Marja-Liisa Karjalainen-Lindsberg, Susanna Mannisto, Pirkko-Liisa Kellokumpu-Lehtinen, Olli Kallioniemi, Satu Mustjoki, Sirpa Leppä

https://doi.org/10.3324/haematol.2018.200105

miR-497 suppresses cycle progression through an axis involving CDK6 in ALK-positive cells

Coralie Hoareau-Aveilla, Cathy Quelen, Annabelle Congras, Nina Caillet, Delphine Labourdette, Christine Dozier, Pierre Brousset, Laurence Lamant, Fabienne Meggetto

https://doi.org/10.3324/haematol.2018.195131

Chronic Lymphocytic Leukemia

Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

Panagiotis Baliakas, Theodoros Moysiadis, Anastasia Hadzidimitriou, Aliki Xochelli, Sabine Jeromin, Andreas Agathangelidis, Mattias Mattsson, Lesley-Ann Sutton, Eva Minga, Lydia Scarfò, Davide Rossi, Zadie Davis, Neus Villamor, Helen Parker, Jana Kotaskova, Evangelia Stalika, Karla Plevova, Larry Mansouri, Diego Cortese, Alba Navarro, Julio Delgado, Marta Larrayoz, Emma Young, Achilles Anagnostopoulos, Karin E. Smedby, Gunnar Juliusson, Oonagh Sheehy, Mark Catherwood, Jonathan C. Strefford, Niki Stavroyianni, Chrysoula Belessi, Sarka Pospisilova, David Oscier, Gianluca Gaidano, Elias Campo, Claudia Haferlach, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos

https://doi.org/10.3324/haematol.2018.195032

Plasma Cell Disorders

Allogeneic transplantation of multiple myeloma patients may allow long-term survival in carefully selected patients with acceptable toxicity and preserved quality of life

Christine Greil, Monika Engelhardt, Gabriele Ihorst, Katja Schoeller, Hartmut Bertz, Reinhard Marks, Robert Zeiser, Justus Duyster, Hermann Einsele, Jürgen Finke, Ralph Wäsch

https://doi.org/10.3324/haematol.2018.200881

Long-term follow up of tandem autologous-allogeneic hematopoietic cell transplantation for multiple myeloma

Enrico Maffini, Barry E. Storer, Brenda M. Sandmaier, Benedetto Bruno, Firoozeh Sahebi, Judith A. Shizuru, Thomas R. Chauncey, Parameswaran Hari, Thoralf Lange, Michael A. Pulsipher, Peter A. McSweeney, Leona Holmberg, Pamela S. Becker, Damian J. Green, Marco Mielcarek, David G. Maloney, Rainer Storb

https://doi.org/10.3324/haematol.2018.200253

Stem Cell Transplantation

Blood Transfusion

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

Maaike Rijkers, David Schmidt, Nina Lu, Cynthia S.M. Kramer, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Frank W.G. Leebeek, A.J. Gerard Jansen, Ilse Jongerius, Sacha S. Zeerleder, Gestur Vidarsson, Jan Voorberg, Masja de Haas

https://doi.org/10.3324/haematol.2018.201665

Online Only Articles

Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study

Eduard J. van Beers, Stephanie van Straaten, D. Holmes Morton, Wilma Barcellini, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, Satheesh Chonat, Janet L. Kwiatkowski, Jennifer A. Rothman, Mukta Sharma, Ellis J. Neufeld, Sujit Sheth, Jenny M. Despotovic, Nina Kollmar, Dagmar Pospíšilová, Christine M. Knoll, Kevin Kuo, Yves D. Pastore, Alexis A. Thompson, Peter E. Newburger, Yaddanapudi Ravindranath, Winfred C. Wang, Marcin W. Wlodarski, Heng Wang, Susanne Holzhauer, Vicky R. Breakey, Madeleine Verhovsek, Joachim Kunz, Melissa A. McNaull, Melissa J. Rose, Heather A. Bradeen, Kathryn Addonizio, Anran Li, Hasan Al-Sayegh, Wendy B. London, Rachael F. Grace

https://doi.org/10.3324/haematol.2018.196295

Bone marrow mesenchymal stem/stromal cells from risk-stratified acute myeloid leukemia patients are anti-inflammatory in in vivo preclinical models of hematopoietic reconstitution and severe colitis

Rafael Diaz de la Guardia, Belen Lopez-Millan, Heleia Roca-Ho, Clara Bueno, Francisco Gutiérrez-Agüera, Jose Luis Fuster, Eduardo Anguita, Samanta Romina Zanetti, Susana Vives, Josep Nomdedeu, Robert Sackstein, Jessie Lavoie, Elena Gónzalez-Rey, Mario Delgado, Michael Rosu-Myles, Pablo Menendez

https://doi.org/10.3324/haematol.2018.196568

Relationship between CD33 expression, splicing polymorphism, and in vitro cytotoxicity of gemtuzumab ozogamicin and the CD33/CD3 BiTE® AMG 330

George S. Laszlo, Mary E. Beddoe, Colin D. Godwin, Olivia M. Bates, Chelsea J. Gudgeon, Kimberly H. Harrington, Roland B. Walter

https://doi.org/10.3324/haematol.2018.202069

ABVD plus rituximab versus ABVD alone for advanced stage, high-risk classical Hodgkin lymphoma: a randomized phase 2 study

Paolo Strati, Michelle A. Fanale, Yasuhiro Oki, Francesco Turturro, Luis E Fayad, Nancy L. Bartlett, Douglas E. Gladstone, Yvette L. Kasamon, Carol S. Portlock, Wyndham H. Wilson, Andre Goy, Anas Younes, Hun Ju Lee

https://doi.org/10.3324/haematol.2018.199844

Efficacy of venetoclax monotherapy in patients with relapsed, refractory mantle cell lymphoma after Bruton tyrosine kinase inhibitor therapy

Toby A. Eyre, Harriet S. Walter, Sunil Iyengar, George Follows, Matthew Cross, Christopher P. Fox, Andrew Hodson, Josh Coats, Santosh Narat, Nick Morley, Martin J.S. Dyer, Graham P. Collins

https://doi.org/10.3324/haematol.2018.198812

Long non-coding RNA NEAT1 shows high expression unrelated to molecular features and clinical outcome in multiple myeloma

Elisa Taiana, Domenica Ronchetti, Vanessa Favasuli, Katia Todoerti, Martina Manzoni, Nicola Amodio, Pierfrancesco Tassone, Luca Agnelli, Antonino Neri

https://doi.org/10.3324/haematol.2018.201301

Case Reports to the Editor

Unrelated cord blood transplantation and post-transplant cyclophosphamide

Andrea Bacigalupo, Simona Sica, Luca Laurenti, Federica Sora’, Sabrina Giammarco, Elisabetta Metafuni, Idanna Innocenti, Francesco Autore, Luciana Teofili, Maria Bianchi, Patrizia Chiusolo

https://doi.org/10.3324/haematol.2018.202598

MPI-CDG with transient hypoglycosylation and antithrombin deficiency

María Eugenia de la Morena-Barrio, Ewa Wypasek, Danuta Owczarek, Antonia Miñano, Vicente Vicente, Javier Corral, Anetta Undas

https://doi.org/10.3324/haematol.2018.211326

Comments

Prevention of serious infections in hereditary hemorrhagic telangiectasia: roles for prophylactic antibiotics, the pulmonary capillaries-but not vaccination

Claire Shovlin, Kathleen Bamford, Carlo Sabbà, Hans-Jurgen Mager, Anette Kjeldsen, Freya Droege, Elisabetta Buscarini, Sophie Dupuis-Girod

https://doi.org/10.3324/haematol.2018.209791