CURRENT ISSUE
August, 2026
No. 111 (8)

Landmark papers in Hematology

1

Editorials

7

Review Articles

1

Perspective Articles

1

Articles

12
Acute Lymphoblastic Leukemia

Successful re-exposure to high-dose methotrexate after severely delayed methotrexate elimination and renal toxicity in children with acute lymphoblastic leukemia (984 Online Views)

Shlomit Barzilai-Birenboim, Nira Arad-Cohen, Edit Bardi, Jesper Heldrup, Gábor Kovács, Marion Mateos, Anja Moericke, Natanja Oosterom, Saskia Sonnenberg, Freya Steinhauer, Goda E. Vaitkevičienė, Inge M. van der Sluis, Sigal M. Weinreb, Ester Zapotocka, David Zucker, Kjeld Schmiegelow, Torben Stamm Mikkelsen

https://doi.org/10.3324/haematol.2025.300277
Acute Myeloid Leukemia

m6A and NuRD complexes regulate monocytic differentiation and resistance to BCL2/BCL2L1 inhibitors in acute myeloid leukemia (1470 Online Views)

Jackson Brim-Edwards, Karen Morris, Quinlan Morrow, Stephen E. Kurtz, Daniel Bottomly, Shannon K. McWeeney, Cristina E. Tognon, Tamilla Nechiporuk, Kevin Watanabe-Smith, Jeffrey W. Tyner

https://doi.org/10.3324/haematol.2025.287972
Cell Therapy & Immunotherapy

ICANS mitigation in high-risk elderly patients treated with CD28 co-stimulatory anti-CD19 CAR-T cells using a standardization protocol: a pilot study (777 Online Views)

Gil Fridberg, Odelia Amit, Yehonathan Sherf, Chava Perry, Yair Herishanu, Erel Joffe, Tamir Shragai, Roy Vitkon, Meir Preis, Shoshan Perk, Nadav Sarid, Sharon Ben Barouch, Ronit Gold, Chen Glait-Santar, Irit Avivi, Ron Ram

https://doi.org/10.3324/haematol.2025.288954

Real-world outcomes in refractory chronic graft-versus-host disease: the Italian multicenter experience with belumosudil (1282 Online Views)

Francesca Bonifazi, Marcello Roberto, Maria Teresa Lupo Stanghellini, Patrizia Chiusolo, Nicola Polverelli, Antonella Geromin, Lucia Prezioso, Mattia Algeri, Giorgia Mancini, Giulia Prunotto, Alessandra Algarotti, Chiara Nozzoli, Michele Malagola, Nicola Mordini, Marilena Fedele, Lidia Santoro, Francesco Zallio, Luca Castagna, Alessandra Picardi, Alessandro Busca, Luisa Giaccone, Cristina Skert, Francesca Elice, Luca Facchini, Jacopo Mariotti, Antonio Pierini, Alessandro Spina, Roberta De Marchi, Dalila Salvatore, Massimo Martino, Manuela Tumino, Alessandro Rambaldi, Franco Locatelli

https://doi.org/10.3324/haematol.2025.289302
Coagulation & its Disorders

Fibrin-bound thrombin determines clot structure and blood thrombogenicity in normofibrinogenemia and dysfibrinogenemia (1069 Online Views)

Siyu Sun, Mark Roest, Rolf T. Urbanus, Elena Campello, Sarah Beck, Cristiana Bulato, Simon D. Connell, Philip G. de Groot, Timea Feller, Dana Huskens, Joke Konings, Rita Marchi, Harmen Middelveld, Patricia Oftering, Bernhard Nieswandt, Alessandro Casini, Robert A.S. Ariens, Paolo Simioni, Johan W.M. Heemskerk, Bas de Laat

https://doi.org/10.3324/haematol.2025.288585

Extracellular microvesicles from patients with antiphospholipid syndrome carry antigenic targets and promote endothelial cell activation in vitro (556 Online Views)

Antonella Capozzi, Gloria Riitano, Serena Recalchi, Agostina Longo, Valeria Manganelli, Silvia Mancuso, Cristiano Alessandri, Roberta Misasi, Tina Garofalo, Maurizio Sorice, Simona Truglia, Fabrizio Conti

https://doi.org/10.3324/haematol.2025.288860
Immune Cytopenias

Increased percentages of circulating T follicular helper cells associate with disease subtype and activity in pediatric immune cytopenias (1273 Online Views)

Emily M. Harris, Aleksandra Bourdine, Logan Magin, Megan Elkins, Matthew Nikiciuk, Anne Chu, Deena Wafadari, Silvia Nastasio, Rebecca Hale, Leetah Senkpeil, Shira Rockowitz, Piotr Sliz, Craig D. Platt, Brenna LaBere, Caitlin Montcrieff, Sarah Chamseddine, Toshiro K. Ohsumi, Rachael F. Grace, Janet Chou

https://doi.org/10.3324/haematol.2025.287988
Non-Hodgkin Lymphoma

Mutational and copy number analysis at diagnosis and relapse of mantle cell lymphoma (1374 Online Views)

Erel Joffe, Manik Uppal, Serena Zheng, Kurt S. Bantilan, Connie Batlevi, Zachary Epstein-Peterson, Paola Ghione, Paul Hamlin, Matthew Matasar, Alison Moskowitz, Ariela Noy, Maria L. Palomba, Gotfried Von Keudell, Lorenzo Falchi, Joachim Yahalom, Vitaly Segodin, Nikita Kotlov, Evgeniy Egorov, Sandrine Degryse, Aleksander Bagaev, Nathan Fowler, Maria Arcila, Ahmet Dogan, Gilles Salles, Anita Kumar, Andrew D. Zelenetz

https://doi.org/10.3324/haematol.2024.286813
Plasma Cell Disorders

EZH2 inhibition overcomes immunomodulatory drug resistance in multiple myeloma via a cereblon-dependent pathway (914 Online Views)

Yigen Li, Amy Wilson, Yakinthi Chrisochoidou, Shannon Martin, Sarah Bird, Salomon Morales, Marc Leiro, Zuza Kozik, Nicholas T. Crump, Theodoros I. Roumeliotis, Jyoti Choudhary, Charlotte Pawlyn

https://doi.org/10.3324/haematol.2025.288024

Male sex adversely impacts survival and myeloid malignancy risk in MGUS: a real-world population-based study (762 Online Views)

Eve Roman, Timothy Bagguley, Simon Crouch, Alexandra Smith, Daniel Painter, Debra Howell, Russell Patmore, Reuben Tooze, Catherine Cargo, Ruth De Tute, Andrew Rawstron, Gordon Cook, Christopher Parrish, Frances Seymour

https://doi.org/10.3324/haematol.2025.289200
Platelet Biology & its Disorders

RAP1-RHO small GTPase cross-talk mediates integrindependent and -independent platelet procoagulant response (627 Online Views)

Abigail Ballard-Kordeliski, Nikola Ziegmann, Wyatt Schug, Mark H. Ginsberg, Antje Schaefer, Robert H. Lee, Wolfgang Bergmeier

https://doi.org/10.3324/haematol.2025.288459

Letters to the Editor

20

Genetic and clinical characteristics of 54 pediatric lymphoma patients with variant mutation sites of UNC13D (404 Online Views)

Yanlong Duan, Huixia Gao, Ling Jin, Jing Yang, Shuang Huang, Meng Zhang, Nan Li, Xueliang Yang, Hanli Xu, Tianyou Wang; Beijing Children’s Hospital, Beijing Jiaotong University (Collaborative Group)

https://doi.org/10.3324/haematol.2025.287782

Body mass index during and early after therapy for pediatric acute lymphoblastic leukemia is associated with obesity in survivors (549 Online Views)

Kunanya Suwannaying, Grace C. Zhou, Nawachai Lertvivatpong, Achal Neupane, Kateryna Petrykey, Tomoko Yoshida, Jessica L. Baedke, Piya Rujkijyanont, Carmen L. Wilson, Stephanie B. Dixon, Angela Delaney, Yadav Sapkota, Sue C. Kaste, Gregory T. Armstrong, Ching-Hon Pui, Melissa M. Hudson, Deokumar Srivastava, Kirsten K. Ness, Hiroto Inaba

https://doi.org/10.3324/haematol.2025.288529

Cumulative incidence and factors associated with subsequent myeloid neoplasms in patients with nodal T-follicular helper cell lymphomas (870 Online Views)

Kai Shiang Lin, Mingfei Yan, Nivetha Ganesan, Tiffany Chang, Ahmet Dogan, Zachary Epstein-Peterson, Ozgur Can Eren, Paola Ghione, Varun Iyengar, William Johnson, Katie Ksanznak, Alison Moskowitz, Benedetta Sordi, Steven Horwitz, Wenbin Xiao, Robert Stuver

https://doi.org/10.3324/haematol.2025.288615

FLAG-IDA-venetoclax for high-risk newly diagnosed acute myeloid leukemia: a multicenter real-world study (607 Online Views)

Baher Krayem, Avraham Frisch, Dana Yehudai-Ofir, Israel Henig, Netta Glaubach, Tsila Zuckerman, Arnon Haran, Boaz Nachmias, Shlomzion Aumann

https://doi.org/10.3324/haematol.2025.288866

Extramedullary hematopoiesis in the spleen contributes to natural killer cell development during infection and inflammation (522 Online Views)

Tanja Bulat, Sara Miranda, Jelena Josipović, Lena Amenitsch, Katarzyna Maria Sitnik, Miriam Kleiter, Caroline Lassnig, Dagmar Gotthardt, Mathias Müller, Birgit Strobl

https://doi.org/10.3324/haematol.2025.289028

Morphologic and immunophenotypic characterization of lymphocytosis following BCMA-targeted CAR-T cell therapy in relapsed/refractory multiple myeloma (821 Online Views)

Jiani N. Chai, Paul Dennis Simonson, Kameisha Gulgar, Frank Costanzo, David S. Jayabalan, Mark Bustoros, Giorgio Ga Inghirami, Julia T. Geyer, Mateo Mejia Saldarriaga

https://doi.org/10.3324/haematol.2025.289079

Three-year safety, efficacy, and renal outcomes of mitapivat treatment in sickle cell disease: results from the phase 2 open-label study (626 Online Views)

Geoffrey Z.L. Kuppens, Maria Armila D. Ruiz, Myrthe J. van Dijk, Minke A.E. Rab, Cleo Derichs, Joline Saes, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Santosh L. Saraf, Eduard J. van Beers

https://doi.org/10.3324/haematol.2025.289105

GB2064 (lenumlostat) shows preliminary evidence of bone marrow collagen fibrosis reduction with manageable tolerability in JAK inhibitor-refractory myelofibrosis: results from the MYLOX-1 phase IIa study (533 Online Views)

Richard F Schlenk, Claire N. Harrison, Francesca Palandri, Marco De Gobbi, Federico Itri, Raajit Rampal, Dipti Talaulikar, Brian Jacoby, Vassilios Aslanis, Robert J. Slack, James A. Roper, Hans T. Schambye, Bhupinder Singh, John Mascarenhas

https://doi.org/10.3324/haematol.2025.289108

Bleomycin omission in limited-stage classic Hodgkin lymphoma with negative PET scan after two cycles of ABVD (416 Online Views)

Jiayu Yang, Diego Villa, Alina S. Gerrie, R. Petter Tonseth, Don C. Wilson, François Bénard, Graham W. Slack, Christopher P. Venner, Andrea C. Lo, David W. Scott, Laurie H. Sehn, Kerry J. Savage

https://doi.org/10.3324/haematol.2025.289285

Scott syndrome with novel compound heterozygous pathogenic variants in ANO6 and reduced thrombin generation (504 Online Views)

Amna Ahmed, Samantha J. Montague, Hrushikesh Vyas, Jayna Mistry, Natasha J. Pavey, Sophie R.M. Smith, Liam Griffith, Isobel Clothier, Roseanne Hudson, Emma Faulkner, Richard Buka, Patricia Bignell, Carl Fratter, Kathryn Marshall, Ben Bailiff, Natalie S. Poulter, Bas de Laat, Dana Huskens, Gillian C. Lowe, Steven G. Thomas, Neil V. Morgan

https://doi.org/10.3324/haematol.2025.300111

Ruxolitinib in treatment-naive or corticosteroid-refractory pediatric patients with chronic graft-versus-host disease: final analysis of the phase II REACH5 trial (864 Online Views)

Franco Locatelli, Bulent Antmen, Hyoung Jin Kang, Katsuyoshi Koh, Yoshiyuki Takahashi, Alphan Kupesiz, Maria Gabriela A. Dias Matos, Yogi Chopra, Sunil Bhat, Ho Joon Im, Tayfun Güngör, Meng-Yao Lu, Tommaso Stefanelli, Severine Peyrard, Yvonne Smith, Karen Sinclair, Cristina Diaz-de-Heredia

https://doi.org/10.3324/haematol.2025.300144

A nationwide Italian GIMEMA survey on tandem autologous stem cell transplantation for newly diagnosed multiple myeloma patients treated with daratumumab, bortezomib, thalidomide and dexamethasone (618 Online Views)

Carmine Liberatore, Alfonso Piciocchi, Donatella Vincelli, Katia Mancuso, Maurizio Musso, Gabriele Buda, Daniele Derudas, Laura Pavan, Angelo Belotti, Angela Rago, Laura Paris, Roberto Mina, Concetta Conticello, Elena Rossi, Cristina Skert, Fabrizio Accardi, Cristina Clissa, Elisabetta Antonioli, Francesca Farina, Anna Furlan, Luca Franceschini, Silvia Mangiacavalli, Claudia Cellini, Sara Aquino, Lorenzo De Paoli, Nicola Giuliani, Francesco Vassallo, Valeria Sargentini, Stefano Soddu, Sara Bringhen, Massimo Gentile, Giuseppe Mele, Francesca Patriarca, Sonia More, Francesca Fazio, Pellegrino Musto, Francesco Di Raimondo, Michele Cavo

https://doi.org/10.3324/haematol.2025.300238

Mutual amplification of sensory nerve outgrowth and tumor progression in myeloma (523 Online Views)

Motosumi Nakagawa, Masahiro Hiasa, Jumpei Teramachi, Takeshi Harada, Asuka Oda, Go Nishino, SooHa Matsuki, Mariko Hanawa, Ariunzaya Bat-Erdene, Takako Taniguchi, Hisaaki Taniguchi, Koichi Tsuneyama, Tatsuya Tominaga, Eiji Tanaka, Takeshi Y. Hiyama, Ken-ichi Matsuoka, Yoshio Katayama, Masahiro Abe

https://doi.org/10.3324/haematol.2025.300309

Real-world outcomes of newly diagnosed multiple myeloma patients treated with front-line daratumumab bortezomib lenalidomide and dexamethasone (1778 Online Views)

Ricardo D. Parrondo, Ricardo de Menezes, Hanna Sledge, Madhavi Nayyar, Kanika Yadav, Leif Bergsagel, Rafael Fonseca, Prashant Kapoor, Francis Buadi, Morie A. Gertz, Angela Dispenzieri, Vivek Roy, Taimur Sher, Moritz Binder, Nadine Abdallah, Saurabh Chhabra, Vincent S. Rajkumar, Wilson I. Gonsalves, Joselle Cook, David Dingli, Yi Lin, Andre Fernandez, Caitlin Flott, Udit Yadav, Rahma M. Warsame, Erin E. Wiedmeier-Nutor, Taxiarchis Kourelis, Nelson Leung, Mustaqeem A. Siddiqui, Shaji Kumar, Asher A. Chanan-Khan, Sikander Ailawadhi

https://doi.org/10.3324/haematol.2025.300401

Nationwide analysis of acute promyelocytic leukemia: incidence and patient outcomes in Germany (449 Online Views)

David Baden, Nadine Wolgast, Leo Ruhnke, Klaus Metzeler, Thomas Beder, Alexander Pohlmann, Sophie Steinhäuser, Jacqueline Müller-Nordhorn, Alexander Katalinic, Maria Teresa Voso, Claudia D. Baldus, Lars Fransecky

https://doi.org/10.3324/haematol.2025.300427

Case Reports & Case Series

4

An unusual case of basophilic meningitis revealing a chronic-phase chronic myeloid leukemia: a report after almost three years of follow-up (321 Online Views)

Ramy Rahmé, Matteo Dragani, Carole Fleury, Giulia Tueur, Paule Moussounda Bamba, Héloïse Torres-Villaros, Audrey Giocanti-Aurégan, Roland Bangbotche, Gregory Lazarian, Fanny Baran-Marszak, Claude Gardin, Thorsten Braun

https://doi.org/10.3324/haematol.2025.300120

Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome during treatment with the bivalent CD20xCD3 bispecific antibody glofitamab (394 Online Views)

Alberto Fresa, Annarosa Cuccaro, Matteo Bonanni, Domenico Galati, Gerardo Ferrara, Francesco Volzone, Stefania Crisci, Maria Rivieccio, Maria Oro, Eliana Morgillo, Sara Mele, Rosaria De Filippi, Antonio Pinto

https://doi.org/10.3324/haematol.2025.300326

Clinical and therapeutic impact of newborn screeningbased early detection of ataxia-telangiectasia (293 Online Views)

Silvia Ricci, Federica Barbati, Emilia Boccieri, Francesco Quagliarella, Clementina Canessa, Francesca Quaranta, Caterina Pelosi, Lorenzo Lodi, Chiara Azzari, Franco Locatelli

https://doi.org/10.3324/haematol.2025.300440

Errata

2

Erratum to: “A simplified frailty score predicts outcome in curatively treated older patients with classical Hodgkin lymphoma” (2 Online Views)

Kjersti Lia, Rasmus Rask Kragh Jørgensen, Per Wikman, Bente L. Wold, Ninja Övergaard, Øystein Fluge, Unn-Merete Fagerli, Hanne Bersvendsen, Idun B. Bø, Sameer Bhargava, Daniel Molin, Alexander Fosså

https://doi.org/10.3324/haematol.2026.289423

Erratum to: “Tumor burden-guided dosing contributes to mitigation of immunotoxicities following treatment with obecabtagene autoleucel in adult patients with relapsed/ refractory B-cell acute lymphoblastic leukemia” (2 Online Views)

Elias Jabbour, Karamjeet S. Sandhu, Paul Shaughnessy, Aaron C. Logan, Mehrdad Abedi, Bijal D. Shah, Michael R. Bishop, Jae H. Park, Daniel J. DeAngelo, Eleni Tholouli, Deborah Yallop, Sridhar Chaganti, Katharine Hodby, Pere Barba, Manuel Guerreiro, Tobias Menne, Justin Shang, Pierre Lao-Sirieix, Wolfram Brugger, Karl S. Peggs, Claire Roddie

https://doi.org/10.3324/haematol.2026.289465