January, 2024
No. 109 (1)

Landmark papers in Hematology

Editorials

Review Articles

Spotlight Review

Articles

Acute Lymphoblastic Leukemia

Genomic analysis of venous thrombosis in children with acute lymphoblastic leukemia from diverse ancestries (1038 Online Views)

Yan Zheng, Wenjian Yang, Jeremie Estepp, Deqing Pei, Cheng Cheng, Clifford M. Takemoto, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Mary V. Relling, Seth E. Karol

https://doi.org/10.3324/haematol.2022.281582

Acute Myeloid Leukemia

Effect of age and treatment on predictive value of measurable residual disease: implications for clinical management of adult patients with acute myeloid leukemia (1213 Online Views)

Francesco Mannelli, Matteo Piccini, Sara Bencini, Giacomo Gianfaldoni, Benedetta Peruzzi, Roberto Caporale, Barbara Scappini, Laura Fasano, Elisa Quinti, Gaia Ciolli, Andrea Pasquini, Francesca Crupi, Sofia Pilerci, Fabiana Pancani, Leonardo Signori, Danilo Tarantino, Chiara Maccari, Vivian Paradiso, Francesco Annunziato, Paola Guglielmelli, Alessandro M. Vannucchi

https://doi.org/10.3324/haematol.2023.283196

Fludarabine, cytarabine, and idarubicin with or without venetoclax in patients with relapsed/refractory acute myeloid leukemia (2033 Online Views)

Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Adrian Schwarzer, Arnold Kloos, Christian Koenecke, Michael Stadler, Gudrun Gohring, Yvonne Lisa Behrens, Zhixiong Li, Louisa-Kristin Dallmann, Piroska Klement, Catherin Albert, Martin Wichmann, Yasmine Alwie, Axel Benner, Maral Saadati, Arnold Ganser, Felicitas Thol, Michael Heuser

https://doi.org/10.3324/haematol.2023.282912

SUMOylation inhibitor TAK-981 (subasumstat) synergizes with 5-azacytidine in preclinical models of acute myeloid leukemia (2042 Online Views)

Ludovic Gabellier, Marion De Toledo, Mehuli Chakraborty, Dana Akl, Rawan Hallal, Mays Aqrouq, Giovanni Buonocore, Clara Recasens-Zorzo, Guillaume Cartron, Abigaïl Delort, Marc Piechaczyk, Denis Tempé, Guillaume Bossis

https://doi.org/10.3324/haematol.2023.282704

Outcomes after intensive chemotherapy for secondary and myeloid-related changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry (1328 Online Views)

David Martínez-Cuadrón, Juan E. Megías-Vericat, Cristina Gil, Teresa Bernal, Mar Tormo, Pilar Martínez-Sánchez, Carlos Rodríguez-Medina, Josefina Serrano, Pilar Herrera, José A. Pérez Simón, María J. Sayas, Juan Bergua, Esperanza Lavilla-Rubira, Maria Luz Amigo, Celina Benavente, Jose L. López Lorenzo, Manuel M. Pérez-Encinas, María B. Vidriales, Mercedes Colorado, Beatriz de Rueda, Raimundo García-Boyero, Sandra Marini, Julio García-Suárez, María López-Pavía, Maria I. Gómez-Roncero, Víctor Noriega, Aurelio López, Jorge Labrador, Ana Cabello, Claudia Sossa, Lorenzo Algarra, Mariana Stevenazzi, Antonio Solana-Altabella, Blanca Boluda, Pau Montesinos

https://doi.org/10.3324/haematol.2022.282506

Cell Therapy & Immunotherapy

Treg-targeted IL-2/anti-IL-2 complex controls graft-versus-host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation (914 Online Views)

Allan Thiolat, Caroline Pilon, Pamela Caudana, Audrey Moatti, Nhu Hanh To, Christine Sedlik, Mathieu Leclerc, Sébastien Maury, Eliane Piaggio, José L. Cohen

https://doi.org/10.3324/haematol.2022.282653

Patient-reported treatment response in chronic graft-versus-host disease (1141 Online Views)

Annie Im, Iskra Pusic, Lynn Onstad, Carrie L. Kitko, Betty K. Hamilton, Amin M. Alousi, Mary E. Flowers, Stefanie Sarantopoulos, Paul Carpenter, Jennifer White, Sally Arai, Najla El Jurdi, George Chen, Corey Cutler, Stephanie Lee, Joseph Pidala

https://doi.org/10.3324/haematol.2023.282734

Chronic Lymphocytic Leukemia

Pro-inflammatory cells sustain leukemic clonal expansion in T-cell large granular lymphocyte leukemia (844 Online Views)

Cristina Vicenzetto, Vanessa Rebecca Gasparini, Gregorio Barila, Antonella Teramo, Giulia Calabretto, Elisa Rampazzo, Samuela Carraro, Valentina Trimarco, Livio Trentin, Monica Facco, Gianpietro Semenzato, Renato Zambello

https://doi.org/10.3324/haematol.2022.282306

Hematopoiesis

Adenosine signaling inhibits erythropoiesis and promotes myeloid differentiation (1070 Online Views)

Mahmoud Mikdar, Marion Serra, Elia Colin, Romain Duval, Emilie-Fleur Gauthier, Yann Lamarre, Yves Colin, Caroline Le Van Kim, Thierry Peyrard, Bérengère Koehl, Slim Azouzi

https://doi.org/10.3324/haematol.2022.281823

Non-Hodgkin Lymphoma

Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax (913 Online Views)

Fen Zhu, Jennifer L. Crombie, Wei Ni, Nguyet-Minh Hoang, Swati Garg, Liam Hackett, Stephen J. F. Chong, Mary C. Collins, Lixin Rui, James Griffin, Matthew S. Davids

https://doi.org/10.3324/haematol.2023.283245

Diffuse large B-cell lymphoma involving osseous sites: utility of response assessment by PET/CT and good longterm outcomes (972 Online Views)

Paola Ghione, Salma Ahsanuddin, Efrat Luttwak, Sabela Bobillo Varela, Reiko Nakajima, Laure Michaud, Kanika Gupta, Anastasia Navitski, David Straus, M. Lia Palomba, Alison Moskowitz, Ariela Noy, Paul Hamlin, Matthew Matasar, Anita Kumar, Lorenzo Falchi, Joachim Yahalom, Steven Horwitz, Andrew Zelenetz, Anas Younes, Gilles Salles, Heiko Schöder, Erel Joffe

https://doi.org/10.3324/haematol.2022.282643

Safety and efficacy of tenalisib in combination with romidepsin in patients with relapsed/refractory T-cell lymphoma: results from a phase I/II open-label multicenter study (901 Online Views)

Swaminathan P. Iyer, Auris Huen, Weiyun Z. Ai, Deepa Jagadeesh, Mary J. Lechowicz, Craig Okada, Tatyana A. Feldman, Paola Ghione, Juan P. Alderuccio, Rebecca Champion, Seo-Hyun Kim, Ann Mohrbacher, Kasi V. Routhu, Prajak Barde, Ajit M. Nair, Bradley M. Haverkos

https://doi.org/10.3324/haematol.2022.281875

Plasma Cell Disorders

Daratumumab in first-line treatment of patients with light chain amyloidosis and Mayo stage IIIb improves treatment response and overall survival (1116 Online Views)

Sara Oubari, Ute Hegenbart, Renate Schoder, Maximilian Steinhardt, Maria Papathanasiou, Tienush Rassaf, Andreas Thimm, Tim Hagenacker, Eyad Naser, Ulrich Duhrsen, Hans C. Reinhardt, Martin Kortum, Hermine Agis, Stefan Schonland, Alexander Carpinteiro

https://doi.org/10.3324/haematol.2023.283325

DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification (992 Online Views)

Vanessa K. Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Giuseppina Fabbiano, Valentina Traini, Katia Todoerti, Silvia Erratico, Alessia Ciarrocchi, Valentina Fragliasso, Domenica Giannandrea, Francesca Tumiatti, Raffaella Chiaramonte, Yvan Torrente, Palma Finelli, Eugenio Morelli, Nikhil C. Munshi, Niccolò Bolli, Antonino Neri, Elisa Taìana

https://doi.org/10.3324/haematol.2023.283274

Elotuzumab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: a multicenter, retrospective, real-world experience with 200 cases outside of controlled clinical trials (1376 Online Views)

Massimo Gentile, Ernesto Vigna, Salvatore Palmieri, Monica Galli, Daniele Derudas, Roberto Mina, Roberta Della Pepa, Renato Zambello, Enrica Antonia Martino, Antonella Bruzzese, Silvia Mangiacavalli, Elena Zamagni, Catello Califano, Maurizio Musso, Concetta Conticello, Claudio Cerchione, Giuseppe Mele, Nicola Di Renzo, Massimo Offidani, Giuseppe Tarantini, Gloria Margiotta Casaluci, Angela Rago, Roberto Ria, Giuseppina Uccello, Gregorio Barilà, Gaetano Palumbo, Alessandra Pompa, Donatella Vincelli, Marino Brunori, Fabrizio Accardi, Valeria Amico, Angela Amendola, Raffaele Fontana, Velia Bongarzoni, Bernardo Rossini, Emilia Cotzia, Alessandro Gozzetti, Rita Rizzi, Nicola Sgherza, Eleonora Ferretti, Giuseppe Bertuglia, Davide Nappi, Maria Teresa Petrucci, Francesco Di Raimondo, Antonino Neri, Fortunato Morabito, Pellegrino Musto

https://doi.org/10.3324/haematol.2023.283251

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma (1051 Online Views)

Yanmeng Wang, Catharina Muylaert, Arne Wyns, Philip Vlummens, Kim De Veirman, Karin Vanderkerken, Esther Zaal, Celia Berkers, Jérome Moreaux, Elke De Bruyne, Eline Menu

https://doi.org/10.3324/haematol.2023.282866

Impact of viral hepatitis therapy in multiple myeloma and other monoclonal gammopathies linked to hepatitis B or C viruses (2419 Online Views)

Alba Rodríguez-García, Nicolas Mennesson, Gema Hernandez-Ibarburu, María Luz Morales, Laurent Garderet, Lorine Bouchereau, Sophie Allain-Maillet, Eric Piver, Irene Marbán, David Rubio, Edith Bigot-Corbel, Joaquín Martínez-López, María Linares, Sylvie Hermouet

https://doi.org/10.3324/haematol.2023.283096

Letters to the Editor

SARS-CoV-2 vaccination in 361 non-transplanted patients with aplastic anemia and/or paroxysmal nocturnal hemoglobinuria (984 Online Views)

Morag Griffin, Dirk-Jan Eikema, Inge Verheggen, Alexander Kulagin, Jennifer M-L. Tjon, Bruno Fattizzo, Wendy Ingram, Uzma Zaidi, Lana Desnica, Sabrina Giammarco, Joanna Drozd-Sokolowska, Blanca Xicoy, Andrea Patriarca, Michael Loschi, Anna Szmigielska-Kaplon, Fabian Beier, Alessandro Cignetti, Beatrice Drexler, Eleni Gavriilaki, Francesco Lanza, Corentin Orvain, Antonio Maria Risitano, Rafael de la Camara, Régis Peffault de Latour

https://doi.org/10.3324/haematol.2023.283863

Molecular predictors of response and survival following IDH1/2 inhibitor monotherapy in acute myeloid leukemia (698 Online Views)

Naseema Gangat, Kristen McCullough, Maymona Abdelmagid, Omer Karrar, Marissa Powell, Aref Al-Kali, Hassan Alkhateeb, Kebede Begna, Abhishek Mangaonkar, Antoine Saliba, Mehrdad Hefazi Torghabeh, Mark Litzow, William Hogan, Mithun Shah, Mrinal Patnaik, Animesh Pardanani, Talha Badar, James Foran, Jeanne Palmer, Lisa Sproat, Cecilia Arana Yi, Ayalew Tefferi

https://doi.org/10.3324/haematol.2023.283732

Myeloid lineage switch in KMT2A-rearranged acute lymphoblastic leukemia treated with lymphoid lineagedirected therapies (1058 Online Views)

Alex Bataller, Tareq Abuasab, David McCall, Wei Wang, Branko Cuglievan, Ghayas C. Issa, Elias Jabbour, Nicholas Short, Courtney D. DiNardo, Guilin Tang, Guillermo Garcia-Manero, Hagop M. Kantarjian, Koji Sasaki

https://doi.org/10.3324/haematol.2023.283705

Red cell distribution width as a new prognostic biomarker in refractory chronic graft-versus-host disease (589 Online Views)

Eduard Schulz, Filip Pirsl, Noa G. Holtzman, David Beshensky, Edward W. Cowen, Sandra A. Mitchell, Seth M. Steinberg, Steven Z. Pavletic

https://doi.org/10.3324/haematol.2023.283646

Impaired T-cell response to mRNA vaccination heralds risk of COVID-19 in long-term allogeneic hematopoietic stem cell transplantation survivors (591 Online Views)

Sigrun Einarsdottir, Jesper Waldenström, Andreas Törnell, Johan Ringlander, Joakim B. Stenbäck, Sebastian Malmström, Kristoffer Hellstrand, Anna Martner, Martin Lagging

https://doi.org/10.3324/haematol.2023.283551

Colchicine reduces inflammation in a humanized transgenic murine model of sickle cell disease (855 Online Views)

Raghda T. Fouda, Hemanth M. Cherukury, Stacy B. Kiven, Natalie R. Garcia, Donovan A. Argueta, Graham J. Velasco, Kalpna Gupta, John D. Roberts

https://doi.org/10.3324/haematol.2023.283377

Optimizing transplantation procedures through identification of prognostic factors in second remission for children with acute myeloid leukemia with no prior history of transplant (685 Online Views)

Hisashi Ishida, Shin-ichi Tsujimoto, Daisuke Hasegawa, Hirotoshi Sakaguchi, Shohei Yamamoto, Masakatsu Yanagimachi, Katsuyoshi Koh, Akihiro Watanabe, Asahito Hama, Yuko Cho, Kenichiro Watanabe, Maiko Noguchi, Masanobu Takeuchi, Junko Takita, Kana Washio, Keisuke Kato, Takashi Koike, Yoshiko Hashii, Ken Tabuchi, Moeko Hino, Yoshiko Atsuta, Yasuhiro Okamoto

https://doi.org/10.3324/haematol.2023.283203

Inflammation is predictive of outcome in Waldenström macroglobulinemia treated by Bruton tyrosine kinase inhibitors: a multicentric real-life study (839 Online Views)

Pierre-Edouard Debureaux, Nathalie Forgeard, Dikelele Elessa, Stéphanie Harel, Laurent Frenzel, Bruno Royer, Alexis Talbot, Sylvain Choquet, Frederic Davi, Florence Nguyen-Khac, Wendy Cuccuini, Morgane Cheminant, Clotilde Bravetti, Gregory Lazarian, Sophie Kaltenbach, Olivier Hermine, Damien Roos-Weil, Marion Espéli, Karl Balabanian, Bertrand Arnulf

https://doi.org/10.3324/haematol.2023.283141

Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation (834 Online Views)

Li Guo, Shancy Jacob, Bhanu Kanth Manne, E. Motunrayo Kolawole, Siqi Guo, Xiang Wang, Darian Murray, Emilia A. Tugolukova, Irina Portier, Yasuhiro Kosaka, Cindy Barba, Matthew T. Rondina, Brian Evavold, Celeste Morley, Seema Bhatlekar, Paul F. Bray

https://doi.org/10.3324/haematol.2023.283016

An accessible patient-derived xenograft model of low-risk myelodysplastic syndromes (748 Online Views)

Patric Teodorescu, Sergiu Pasca, InYoung Choi, Cynthia Shams, W. Brian Dalton, Lukasz P. Gondek, Amy E. DeZern, Gabriel Ghiaur

https://doi.org/10.3324/haematol.2023.282967

Final results and overall survival data from a phase II study of acalabrutinib monotherapy in patients with relapsed/refractory mantle cell lymphoma, including those with poor prognostic factors (2552 Online Views)

Steven Le Gouill, Monika Długosz-Danecka, Simon Rule, Pier Luigi Zinzani, Andre Goy, Stephen D. Smith, Jeanette K. Doorduijn, Carlos Panizo, Bijal D. Shah, Andrew J. Davies, Richard Eek, Eric Jacobsen, Arnon P. Kater, Tadeusz Robak, Preetesh Jain, Roser Calvo, Lin Tao, Michael Wang

https://doi.org/10.3324/haematol.2022.282469

Case Reports

Immune-related adverse events with bispecific T-cell engager therapy targeting B-cell maturation antigen (1309 Online Views)

Bénédicte Piron, Mathilde Bastien, Chloé Antier, Romain Dalla-Torre, Bastien Jamet, Thomas Gastinne, Viviane Dubruille, Philippe Moreau, Jérôme Martin, Antoine Bénichou, Cyrille Touzeau, Benoît Tessoulin

https://doi.org/10.3324/haematol.2023.282919

Comments

Erratum

Erratum to: Comparing the two leading erythroid lines BEL-A and HUDEP-2 (344 Online Views)

Deborah E. Daniels, Damien J. Downes, Ivan Ferrer-Vicens, Daniel C. J. Ferguson, Belinda K. Singleton, Marieangela C. Wilson, Kongtana Trakarnsanga, Ryo Kurita, Yukio Nakamura, David J. Anstee, Jan Frayne

https://doi.org/10.3324/haematol.2023.284510