CURRENT ISSUE
February, 2024
No. 109 (2)

Landmark papers in Hematology

Editorials

Spotlight Review

Review Articles

Articles

Acute Myeloid Leukemia

Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia (1138 Online Views)

Laura W. Dillon, Jake Higgins, Hassan Nasif, Megan Othus, Lan Beppu, Thomas H. Smith, Elizabeth Schmidt, Charles C. Valentine III, Jesse J. Salk, Brent L Wood, Harry P. Erba, Jerald P. Radich, Christopher S. Hourigan

https://doi.org/10.3324/haematol.2023.283520

Bone Marrow Failure

Spontaneous remission and loss of monosomy 7: a window of opportunity for young children with SAMD9L syndrome (934 Online Views)

Miriam Erlacher, Felicia Andresen, Martina Sukova, Jan Stary, Barbara de Moerloose, Jutte van der Werff Ten Bosch, Michael Dworzak, Markus G. Seidel, Sophia Polychronopoulou, Rita Beier, Christian P. Kratz, Michaela Nathrath, Michael C. Frühwald, Gudrun Göhring, Anke K. Bergmann, Christina Mayerhofer, Dirk Lebrecht, Senthilkumar Ramamoorthy, Ayami Yoshimi, Brigitte Strahm, Marcin W. Wlodarski, Charlotte M. Niemeyer

https://doi.org/10.3324/haematol.2023.283591

Cell Therapy & Immunotherapy

Allogeneic hematopoietic stem cell transplantation in patients aged 60-79 years in Germany (1998-2018): a registry study (967 Online Views)

Jan Frederic Weller, Claudia Lengerke, Jürgen Finke, Johannes Schetelig, Uwe Platzbecker, Hermann Einsele, Thomas Schroeder, Christoph Faul, Matthias Stelljes, Peter Dreger, Igor W. Blau, Gerald Wulf, Johanna Tischer, Christoph Scheid, Ahmet Elmaagacli, Helga Neidlinger, Sarah Flossdorf, Martin Bornhäuser, Wolfgang Bethge, Katharina Fleischhauer, Nicolaus Kröger, Liesbeth C. de Wreede, Maximilian Christopeit

https://doi.org/10.3324/haematol.2023.283175

Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization (870 Online Views)

Marion Ciudad, Sethi Ouandji, Baptiste Lamarthée, Claudie Cladière, Thibault Ghesquière, Martin Nivet, Marine Thébault, Romain Boidot, Agnès Soudry-Faure, Sandy Chevrier, Corentin Richard, Thibault Maillet, François Maurier, Hélène Greigert, Coraline Genet, André Ramon, Malika Trad, Valérie Predan, Philippe Saas, Maxime Samson, Bernard Bonnotte, Sylvain Audia

https://doi.org/10.3324/haematol.2023.282859

Ruxolitinib-based regimen in children with primary hemophagocytic lymphohistiocytosis (1140 Online Views)

Jian Ge, Qing Zhang, Honghao Ma, Dong Wang, Yunze Zhao, Ting Zhu, Wenqian Wang, Chenxin Zhou, Ang Wei, Hongyun Lian, Maoquan Qin, Jun Yang, Zhigang Li, Tianyou Wang, Rui Zhang

https://doi.org/10.3324/haematol.2023.283478

Chronic Lymphocytic Leukemia

IGH 3’RR recombination uncovers a non-germinal center imprint and c-MYC-dependent IGH rearrangement in unmutated chronic lymphocytic leukemia (751 Online Views)

Israa Al Jamal, Milene Parquet, Kenza Guiyedi, Said Aoufouchi, Morwenna Le Guillou, David Rizzo, Justine Pollet, Marine Dupont, Melanie Boulin, Nathalie Faumont, Hend Boutouil, Fabrice Jardin, Philippe Ruminy, Chahrazed El Hamel, Justine Lerat, Samar Al Hamaoui, Nehman Makdissy, Jean Feuillard, Nathalie Gachard, Sophie Peron

https://doi.org/10.3324/haematol.2023.282897

BCL3 rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases (1265 Online Views)

Anna Carbo-Meix, Francesca Guijarro, Luojun Wang, Marta Grau, Romina Royo, Gerard Frigola, Heribert Playa-Albinyana, Marco M. Buhler, Guillem Clot, Marti Duran-Ferrer, Junyan Lu, Isabel Granada, Maria-Joao Baptista, Jose-Tomas Navarro, Blanca Espinet, Anna Puiggros, Gustavo Tapia, Laura Bandiera, Gabriella De Canal, Emanuela Bonoldi, Fina Climent, Inmaculada Ribera-Cortada, Mariana Fernandez-Caballero, Esmeralda de la Banda, Janilson do Nascimento, Alberto Pineda, Dolors Vela, Maria Rozman, Marta Aymerich, Charlotte Syrykh, Pierre Brousset, Miguel Perera, Lucrecia Yanez, Jesus Xavier Ortin, Esperanza Tuset, Thorsten Zenz, James R. Cook, Steven H. Swerdlow, Jose I. Martin-Subero, Dolors Colomer, Estella Matutes, Silvia Bea, Dolors Costa, Ferran Nadeu, Elias Campo

https://doi.org/10.3324/haematol.2023.283209

Hematopoiesis

Prognostic relevance of clonal hematopoiesis in myeloid neoplastic transformation in patients with follicular lymphoma treated with radioimmunotherapy (634 Online Views)

Zhuoer Xie, Terra Lasho, Arushi Khurana, Alejandro Ferrer, Christy Finke, Abhishek A. Mangaonkar, Stephen Ansell, Jenna Fernandez, Mithun Vinod Shah, Aref Al-Kali, Naseema Gangat, Jithma Abeykoon, Thomas E. Witzig, Mrinal M. Patnaik

https://doi.org/10.3324/haematol.2023.283727

Myeloproliferative Disorders

Phenotypic profiling of CD34+ cells by advanced flow cytometry improves diagnosis of juvenile myelomonocytic leukemia (972 Online Views)

Cristina Bugarin, Laura Antolini, Chiara Buracchi, Sergio Matarraz, Tiziana Angela Coliva, Vincent H. van der Velden, Tomasz Szczepanski, Elaine Sobral da Costa, Alita van der Sluijs, Michaela Novakova, Ester Mejstrikova, Stefan Nierkens, Fabiana Vieira de Mello, Paula Fernandez, Carmen Aanei, Łukasz Sędek, Luisa Strocchio, Riccardo Masetti, Laura Sainati, Jan Philippé, Maria Grazia Valsecchi, Franco Locatelli, Jacques J.M. van Dongen, Andrea Biondi, Alberto Orfao, Giuseppe Gaipa

https://doi.org/10.3324/haematol.2023.282805

Non-Hodgkin Lymphoma

Results from a phase I trial of pembrolizumab plus vorinostat in relapsed/refractory B-cell non-Hodgkin lymphoma (1041 Online Views)

James Godfrey, Matthew Mei, Lu Chen, Joo Y. Song, Victoria Bedell, Elizabeth Budde, Saro Armenian, Sandrine Puverel, Liana Nikolaenko, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Steven T. Rosen, Stephen J. Forman, Leslie L. Popplewell, Larry W. Kwak, Alex F. Herrera

https://doi.org/10.3324/haematol.2023.283002

Feasibility and outcomes after dose reduction of immunochemotherapy in young adults with Burkitt lymphoma and leukemia: results of the BURKIMAB14 trial (730 Online Views)

Josep-Maria Ribera, Mireia Morgades, Olga Garcia-Calduch, Maialen Sirvent, Buenaventura Buendia, Marta Cervera, Hugo Luzardo, Jesus-Maria Hernandez-Rivas, Marta Sitges, Irene Garcia-Cadenas, Pau Abrisqueta, Pau Montesinos, Mariana Bastos-Oreiro, Maria-Paz Queipo de Llano, Pilar Bravo, Anna Torrent, Pilar Herrera, Antoni Garcia-Guinon, Ferran Vall-llovera, Josefina Serrano, Maria-Jose Terol, Juan-Miguel Bergua, Ana Garcia-Noblejas, Cristina Barrenetxea, Laura Llorente, Daniel Garcia-Belmonte, Eva Gimeno, Antonia Cladera, Santiago Mercadal, Juan-Manuel Sancho

https://doi.org/10.3324/haematol.2023.283342

Tafasitamab for patients with relapsed or refractory diffuse large B-cell lymphoma: final 5-year efficacy and safety findings in the phase II L-MIND study (3011 Online Views)

Johannes Duell, Pau Abrisqueta, Marc Andre, Gianluca Gaidano, Eva Gonzales-Barca, Wojciech Jurczak, Nagesh Kalakonda, Anna Marina Liberati, Kami J Maddocks, Tobias Menne, Zsolt Nagy, Olivier Tournilhac, Christian Kuffer, Abhishek Bakuli, Aasim Amin, Konstantin Gurbanov, Gilles Salles

https://doi.org/10.3324/haematol.2023.283480

Plasma Cell Disorders

PVT1 interacts with polycomb repressive complex 2 to suppress genomic regions with pro-apoptotic and tumour suppressor functions in multiple myeloma (1102 Online Views)

Patrick Nylund, Berta Garrido-Zabala, Alba Atienza Párraga, Louella Vasquez, Paul Theodor Pyl, George Mickhael Harinck, Anqi Ma, Jian Jin, Fredrik Öberg, Antonia Kalushkova, Helena Jernberg Wiklund

https://doi.org/10.3324/haematol.2023.282965

TTK/MPS1 inhibitor OSU-13 targets the mitotic checkpoint and is a potential therapeutic strategy for myeloma (692 Online Views)

Larissa Valle Guilhen Longo, Tiffany Hughes, Betina McNeil-Laidley, Francesca Cottini, Gerard Hilinski, Elizabeth Merritt, Don M. Benson

https://doi.org/10.3324/haematol.2023.282838

Minor clone of del(17p) provides a reservoir for relapse in multiple myeloma (3028 Online Views)

Jian Cui, Rui Lv, Tengteng Yu, Wenqiang Yan, Jingyu Xu, Huishou Fan, Lingna Li, Yuntong Liu, Chenxing Du, Shuhui Deng, Weiwei Sui, Yan Xu, Shuhua Yi, Dehui Zou, Lugui Qiu, Gang An

https://doi.org/10.3324/haematol.2023.283533

Isatuximab plus carfilzomib and dexamethasone in patients with early versus late relapsed multiple myeloma: IKEMA subgroup analysis (2161 Online Views)

Thierry Facon, Philippe Moreau, Ross Baker, Chang-Ki Min, Xavier Leleu, Mohamad Mohty, Lionel Karlin, Nicole M. Armstrong, Christina Tekle, Sandrine Schwab, Marie-Laure Risse, Thomas Martin

https://doi.org/10.3324/haematol.2023.283073

Letters to the Editor

Vaccine utilization and overwhelming post-splenectomy infection risk factors in two asplenia cohorts (547 Online Views)

Matthew A. Soderstrom, Mechelle A. Miller, Qing Wang, William P. Hennrikus, Nora L. Watson, Ryan C. Costantino, Matthew J. Bradley, V. Koneti Rao, Nathan A. Boggs

https://doi.org/10.3324/haematol.2023.283419

Identification of PSMB4 and PSMD4 as novel target genes correlated with 1q21 amplification in patients with smoldering myeloma and multiple myeloma (648 Online Views)

Jessica Burroughs Garcia, Paola Storti, Nicolas Thomas Iannozzi, Valentina Marchica, Luca Agnelli, Denise Toscani, Valentina Franceschi, Giannalisa Todaro, Gabriella Sammarelli, Laura Notarfranchi, Matteo Scita, Benedetta Dalla Palma, Vincenzo Raimondi, Oxana Lungu, Giancarlo Pruneri, Gaetano Donofrio, Nicola Giuliani

https://doi.org/10.3324/haematol.2023.283200

Quantitative evaluation of the clinical severity of hemoglobin H disease in a cohort of 591 patients using a scoring system based on regression analysis (601 Online Views)

Yumeng Liu, Yuan Zhuang, Jianhong Chen, Zeyan Zhong, Jianpei Fang, Xinyu Li, Bin Xiao, Pingping Li, Bin Lin, Zhenzhong Tao, Yidan Liang, Peng Lin, Xingmin Wang, Mengyang Song, Hualei Luo, Lang Qin, Li Huang, Jufang Tan, Hailiang Li, Tianyu Zhong, Lian Yu, Zhixiang Liu, Deguo Tang, Yongzhong Zhao, Xinhua Zhang, Yuhua Ye, Xiangmin Xu

https://doi.org/10.3324/haematol.2023.283211

Thiostrepton induces cell death of acute myeloid leukemia blasts and the associated macrophage population (528 Online Views)

Isabel Weinhäuser, Diego A. Pereira-Martins, Jacobien R. Hilberink, Annet Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Jan Jacob Schuringa

https://doi.org/10.3324/haematol.2023.283621

Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia (649 Online Views)

Hanna M. Ingelman-Sundberg, Lisa Blixt, David Wullimann, Jinghua Wu, Yu Gao, Katie Healy, Sandra Muschiol, Gordana Bogdanovic, Mikael Åberg, Christian Kjellander, Alba Grifoni, Alessandro Sette, Soo Aleman, Puran Chen, Ola Blennow, Lotta Hansson, Hans-Gustaf Ljunggren, Margaret Sällberg Chen, Marcus Buggert, Anders Österborg

https://doi.org/10.3324/haematol.2023.282894

Prognostic value of minimal disseminated disease assessed using digital polymerase chain reaction for 3'ALK assays in pediatric anaplastic lymphoma kinasepositive anaplastic large cell lymphoma (481 Online Views)

Reiji Fukano, Yuka Iijima-Yamashita, Hideto Iwafuchi, Atsuko Nakazawa, Akiko M. Saito, Tetsuya Takimoto, Masahiro Sekimizu, Yutaka Suehiro, Takahiro Yamasaki, Shunji Hasegawa, Tetsuya Mori, Keizo Horibe

https://doi.org/10.3324/haematol.2023.282812

Frequent, high density expression of surface CD38 as a potential therapeutic target in adult T-lineage acute lymphoblastic leukemia (540 Online Views)

Sebastian Koslowski, Rainer Glauben, Stefan Habringer, Thomas Burmeister, Ulrich Keller, Monika Brüggemann, Nicola Gökbuget, Stefan Schwartz

https://doi.org/10.3324/haematol.2023.283814

Oligosecretory Waldenström macroglobulinemia exhibits excellent treatment response and outcomes (2585 Online Views)

Wenjie Xiong, Ying Yu, Chunyan Sun, Juan Du, Zhen Cai, Zanzan Wang, Xinxin Cao, Yuting Yan, Jiawen Chen, Yanshan Huang, Zhongxing Jiang, Huihan Wang, Ting Niu, Guangzhong Yang, Hua Xue, Bingzong Li, Honghui Huang, Zhenling Li, Qinhua Liu, Fei Li, Ou Bai, Min Mao, Rong Fu, Ling Wang, Chunrui Li, Xiaoxia Chu, Lihong Liu, Yujun Dong, Luqun Wang, Jun Luo, Yongqiang Wei, Rui Cui, Lugui Qiu, Jian Li, Shuhua Yi

https://doi.org/10.3324/haematol.2023.283402

Exclusion of persistent mutations in splicing factor genes and isocitrate dehydrogenase 2 improves the prognostic power of molecular measurable residual disease assessment in acute myeloid leukemia (770 Online Views)

Tracy Murphy, Jinfeng Zou, Andrea Arruda, Ting Ting Wang, Zhen Zhao, Yangqiao Zheng, Vikas Gupta, Dawn Maze, Caroline McNamara, Mark D. Minden, Aaron Schimmer, Hassan Sibai, Karen Yee, Jose-Mario Capo-Chichi, Tracy Stockley, Andre Schuh, Scott V. Bratman, Steven M. Chan

https://doi.org/10.3324/haematol.2023.283510

Clinical outcomes of patients with myelofibrosis after immediate transition to momelotinib from ruxolitinib (2309 Online Views)

Ruben Mesa, Srdan Verstovsek, Uwe Platzbecker, Vikas Gupta, David Lavie, Pilar Giraldo, Christian Recher, Jean-Jacques Kiladjian, Stephen T. Oh, Aaron T. Gerds, Timothy Devos, Francesco Passamonti, Alessandro M. Vannucchi, Miklos Egyed, Ewa Lech-Maranda, Andrzej Pluta, Lars Nilsson, Kazuya Shimoda, Donal McLornan, Jun Kawashima, Barbara Klencke, Mei Huang, Bryan Strouse, Claire Harrison

https://doi.org/10.3324/haematol.2023.283106

Case Reports

Immune-mediated facial nerve paralysis in a myeloma patient post B-cell maturation antigen-targeted chimeric antigen receptor T cells (744 Online Views)

Yamini K. Kathari, Haroon Ahmad, Michael E. Kallen, Rima Koka, Destiny Omili, Thierry Iraguha, Jean Clement, Lily Pham, Mazhar Khalid, Xiaoxuan Fan, Etse Gebru, Patricia Lesho, Esther Park, Nishanthini Dishanthan, Jillian M. Baker, Kenneth A. Dietze, Kim G. Hankey, Ashraf Badros, Jean A. Yared, Saurabh Dahiya, Nancy M. Hardy, Hakan Kocoglu, Tim Luetkens, Aaron P. Rapoport, Djordje Atanackovic

https://doi.org/10.3324/haematol.2023.283296

Erratum