CURRENT ISSUE
January, 2023
No. 108 (1)

Editorials

Review Articles

Articles

Acute Myeloid Leukemia

COVID-19 in adult acute myeloid leukemia patients: a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA) (2580 Online Views)

Francesco Marchesi, Jon Salmanton-García, Ziad Emarah, Klára Piukovics, Marcio Nucci, Alberto López-García, Zdeněk Ráčil, Francesca Farina, Marina Popova, Sofia Zompi, Ernesta Audisio, Marie-Pierre Ledoux, Luisa Verga, Barbora Weinbergerová, Tomas Szotkovski, Maria Gomes Da Silva, Nicola Fracchiolla, Nick De Jonge, Graham Collins, Monia Marchetti, Gabriele Magliano, Carolina García-Vidal, Monika M. Biernat, Jaap Van Doesum, Marina Machado, Fatih Demirkan, Murtadha Al-Khabori, Pavel Žák, Benjamín Víšek, Igor Stoma, Gustavo-Adolfo Méndez, Johan Maertens, Nina Khanna, Ildefonso Espigado, Giulia Dragonetti, Luana Fianchi, Maria Ilaria Del Principe, Alba Cabirta, Irati Ormazabal-Vélez, Ozren Jaksic, Caterina Buquicchio, Valentina Bonuomo, Josip Batinić, Ali S. Omrani, Sylvain Lamure, Olimpia Finizio, Noemí Fernández, Iker Falces-Romero, Ola Blennow, Rui Bergantim, Natasha Ali, Sein Win, Jens Van Praet, Maria Chiara Tisi, Ayten Shirinova, Martin Schönlein, Juergen Prattes, Monica Piedimonte, Verena Petzer, Milan Navrátil, Austin Kulasekararaj, Pavel Jindra, Jiří Sramek, Andreas Glenthøj, Rita Fazzi, Cristina De Ramón-Sánchez, Chiara Cattaneo, Maria Calbacho, Nathan C. Bahr, Shaimaa El-Ashwah, Raul Cordoba, Michaela Hanakova, Giovanni Zambrotta, Mariarita Sciumè, Stephen Booth, Raquel Nunes Rodrigues, Maria Vittoria Sacchi, Nicole García-Poutón, Juan-Alberto Martín-González, Sofya Khostelidi, Stefanie Gräfe, Laman Rahimli, Emanuele Ammatuna, Alessandro Busca, Paolo Corradini, Martin Hoenigl, Nikolai Klimko, Philipp Koehler, Antonio Pagliuca, Francesco Passamonti, Oliver A. Cornely, Livio Pagano

https://doi.org/10.3324/haematol.2022.280847

Characteristics and outcome of patients with acute myeloid leukemia and trisomy 4 (935 Online Views)

Sabine Kayser, David Martínez-Cuadrón, Maher Hanoun, Friedrich Stölzel, Cristina Gil, H. Christian Reinhardt, Eliana Aguiar, Kerstin Schäfer-Eckart, Juan Miguel Bergua Burgues, Björn Steffen, Teresa Bernal, Stefan W. Krause, Rosalía Riaza, Christoph Schliemann, Jose Cervera, Martin Kaufmann, Laura Torres-Miñana, Mathias Hänel, Evelyn Acuña-Cruz, Edgar Jost, Jesus Lorenzo Algarra, Martina Crysandt, Lars Fransecky, Javier Cornago-Navascues, Sabrina Kraus, Joaquin Martinez-Lopez, Hermann Einsele, Dirk Niemann, Andreas Neubauer, Ruth Seggewiß-Bernhardt, Sebastian Scholl, Stefan A. Klein, Christoph Schmid, Markus Schaich, Martin Schmidt-Hieber, Sven Zukunft, Anthony D. Ho, Uwe Platzbecker, Claudia D. Baldus, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Hubert Serve, Mark Levis, Pau Montesinos, Christoph Röllig, Richard F. Schlenk

https://doi.org/10.3324/haematol.2022.281137

Analysis of rare driving events in pediatric acute myeloid leukemia (894 Online Views)

Sanne Noort, Jolieke van Oosterwijk, Jing Ma, Elizabeth A.R. Garfinkle, Stephanie Nance, Michael Walsh, Guangchun Song, Dirk Reinhardt, Martina Pigazzi, Franco Locatelli, Henrik Hasle, Jonas Abrahamsson, Marie Jarosova, Charikleia Kelaidi, Sophia Polychronopoulou, Marry M. van den Heuvel-Eibrink, Maarten Fornerod, Tanja A. Gruber, C. Michel Zwaan

https://doi.org/10.3324/haematol.2021.280250

Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia (644 Online Views)

Elise Sourdeau, Ludovic Suner, Mara Memoli, Alexis Genthon, Frédéric Feger, Lou Soret, Nasséra Abermil, Laurence Heuberger, Chrystele Bilhou-Nabera, Hélène Guermouche, Fabrizia Favale, Simona Lapusan, Michael Chaquin, Claire Hirschauer, Mohamad Mohty, Ollivier Legrand, François Delhommeau, Pierre Hirsch

https://doi.org/10.3324/haematol.2022.280676

Bone Marrow Failure

Cell Therapy & Immunotherapy

The efficacy of combination treatment with elotuzumab and lenalidomide is dependent on crosstalk between natural killer cells, monocytes and myeloma cells (1189 Online Views)

Kelden Richardson, Simon P. Keam, Joe Jiang Zhu, Deborah Meyran, Criselle D’Souza, Sean Macdonald, Kerry Campbell, Michael Robbins, Natalie A. Bezman, Kirsten Todd, Hang Quach, David S. Ritchie, Simon J. Harrison, H. Miles Prince, Joseph A. Trapani, Misty R. Jenkins, Paul A. Beavis, Phillip K. Darcy, Paul J. Neeson

https://doi.org/10.3324/haematol.2021.279930

Allogeneic transplant following CAR T-cell therapy for large B-cell lymphoma (2855 Online Views)

Joanna Zurko, Jeremy Ramdial, Mazyar Shadman, Sairah Ahmed, Aniko Szabo, Lorenzo Iovino, Ana Alarcon Tomas, Craig Sauter, Miguel-Angel Perales, Nirav. N. Shah, Utkarsh H. Acharya, Caron Jacobson, Robert J. Soiffer, Trent Wang, Krishna V. Komanduri, Samantha Jaglowski, Adam S. Kittai, Nathan Denlinger, Madiha Iqbal, Mohamed A. Kharfan-Dabaja, Ernesto Ayala, Julio Chavez, Michael Jain, Frederick L. Locke, Yazeed Samara, Lihua E. Budde, Matthew G. Mei, Alexandra Della Pia, Tatyana Feldman, Nausheen Ahmed, Ryan Jacobs, Nilanjan Ghosh, Bhagirathbhai Dholaria, Olalekan O. Oluwole, Brian Hess, Ayesha Hassan, Vaishalee P. Kenkre, Patrick Reagan, Farrukh Awan, Yago Nieto, Mehdi Hamadani, Alex F. Herrera

https://doi.org/10.3324/haematol.2022.281242

Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma (3196 Online Views)

Mi Kwon, Gloria Iacoboni, Juan Luis Reguera, Lucía López Corral, Rafael Hernani Morales, Valentín Ortiz-Maldonado, Manuel Guerreiro, Ana Carolina Caballero, María Luisa Guerra Domínguez, Jose Maria Sanchez Pina, Alberto Mussetti, Juan Manuel Sancho, Mariana Bastos-Oreiro, Eva Catala, Javier Delgado, Hugo Luzardo Henriquez, Jaime Sanz, María Calbacho, Rebeca Bailén, Cecilia Carpio, Jose Maria Ribera, Anna Sureda, Javier Briones, Juan Carlos Hernandez-Boluda, Nuria Martínez Cebrián, Jose Luis Diez Martin, Alejandro Martín, Pere Barba

https://doi.org/10.3324/haematol.2022.280805

Chronic Myeloid Leukemia

RHOA-regulated IGFBP2 promotes invasion and drives progression of BCR-ABL1 chronic myeloid leukemia (1004 Online Views)

Hualei Zhang, Baohuan Cai, Yun Liu, Yating Chong, Atsuko Matsunaga, Stephanie Fay Mori, Xuexiu Fang, Eiko Kitamura, Chang-Sheng Chang, Ping Wang, John K Cowell, Tianxiang Hu

https://doi.org/10.3324/haematol.2022.280757

Iron Metabolism & its Disorders

Comparative analysis of oral and intravenous iron therapy in rat models of inflammatory anemia and iron deficiency (1725 Online Views)

Lara Valente de Souza, Alexander Hoffmann, Christine Fischer, Verena Petzer, Malte Asshoff, Igor Theurl, Piotr Tymoszuk, Markus Seifert, Natascha Brigo, Richard Hilbe, Egon Demetz, Laura Von Raffay, Sylvia Berger, Marina Barros-Pinkelnig, Guenter Weiss

https://doi.org/10.3324/haematol.2022.281149

Myeloproliferative Disorders

The mutational landscape in chronic myelomonocytic leukemia and its impact on allogeneic hematopoietic cell transplantation outcomes: a Center for Blood and Marrow Transplantation Research (CIBMTR) analysis (2135 Online Views)

Matthew Mei, Raju Pillai, Soyoung Kim, Noel Estrada-Merly, Michelle Afkhami, Lixin Yang, Zhuo Meng, Muhammad Bilal Abid, Mahmoud Aljurf, Ulrike Bacher, Amer Beitinjaneh, Christopher Bredeson, Jean-Yves Cahn, Jan Cerny, Edward Copelan, Corey Cutler, Zachariah DeFilipp, Miguel Angel Diaz Perez, Nosha Farhadfar, César O. Freytes, Shahinaz M. Gadalla, Siddhartha Ganguly, Robert Peter Gale, Usama Gergis, Michael R. Grunwald, Betty K. Hamilton, Shahrukh Hashmi, Gerhard C. Hildebrandt, Hillard M. Lazarus, Mark Litzow, Reinhold Munker, Hemant S. Murthy, Sunita Nathan, Taiga Nishihori, Sagar S. Patel, David Rizzieri, Sachiko Seo, Mithun Vinod Shah, Melhem Solh, Leo F. Verdonck, Ravi Vij, Ronald M. Sobecks, Betul Oran, Bart L. Scott, Wael Saber, Ryotaro Nakamura

https://doi.org/10.3324/haematol.2021.280203

Myelodysplastic Syndromes

Non-Hodgkin Lymphoma

Positron emission tomography-imaging assessment for guiding strategy in patients with relapsed/refractory large B-cell lymphoma receiving CAR T cells (1007 Online Views)

Jean Galtier, Laetitia Vercellino, Loic Chartier, Pierre Olivier, Claire Tabouret-Viaud, Charles Mesguich, Roberta Di Blasi, Amandine Durand, Léo Raffy, François-Xavier Gros, Isabelle Madelaine, Veronique Meignin, Miryam Mebarki, Marie-Thérèse Rubio, Pierre Feugier, Olivier Casasnovas, Michel Meignan, Catherine Thieblemont

https://doi.org/10.3324/haematol.2021.280550

Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome (1421 Online Views)

Luis Veloza, Doriane Cavalieri, Edoardo Missiaglia, Albane Ledoux-Pilon, Bettina Bisig, Bruno Pereira, Christophe Bonnet, Elsa Poullot, Leticia Quintanilla-Martinez, Romain Dubois, Francisco Llamas-Gutierrez, Céline Bossard, Roland De Wind, Fanny Drieux, Juliette Fontaine, Marie Parrens, Jeremy Sandrini, Virginie Fataccioli, Marie-Hélène Delfau-Larue, Adrien Daniel, Faustine Lhomme, Lauriane Clément-Filliatre, François Lemonnier, Anne Cairoli, Pierre Morel, Sylvie Glaisner, Bertrand Joly, Abderrazak El Yamani, Kamel Laribi, Emmanuel Bachy, Reiner Siebert, David Vallois, Philippe Gaulard, Olivier Tournilhac, Laurence de Leval

https://doi.org/10.3324/haematol.2022.281226

In-depth characterization of intratumoral heterogeneity in refractory B-cell non-Hodgkin lymphoma through the lens of a Research Autopsy Program (640 Online Views)

Keren Isaev, Ting Liu, Mehran Bakhtiari, Kit Tong, Rashmi Goswami, Bernard Lam, Ilinca Lungu, Paul M. Krzyzanowski, Amit Oza, Neesha Dhani, Anca Prica, Michael Crump, Robert Kridel

https://doi.org/10.3324/haematol.2022.280900

Plasma Cell Disorders

Activation of long non-coding RNA NEAT1 leads to survival advantage of multiple myeloma cells by supporting a positive regulatory loop with DNA repair proteins (793 Online Views)

Elisa Taiana, Cecilia Bandini, Vanessa Katia Favasuli, Domenica Ronchetti, Ilaria Silvestris, Noemi Puccio, Katia Todoerti, Silvia Erratico, Domenica Giannandrea, Niccolò Bolli, Nicola Amodio, Alessia Ciarrocchi, Raffaella Chiaramonte, Yvan Torrente, Roberto Piva, Antonino Neri

https://doi.org/10.3324/haematol.2022.281167

Letters to the Editor

Treatment patterns and clinical outcomes of asciminib in a real-world multiresistant chronic myeloid leukemia patient population (1129 Online Views)

Camille C.B. Kockerols, Jeroen J.W.M Janssen, Nicole M.A. Blijlevens, Saskia K. Klein, Laura G.M. van Hussen-Daenen, Gwendolyn G.Y. van Gorkom, Willem M. Smit, Peter van Balen, Bart J. Biemond, Marjan J. Cruijsen, Maarten F. Corsten, Peter A.W. te Boekhorst, Harry R. Koene, Geerte L. van Sluis, Jan J. Cornelissen, Peter E. Westerweel

https://doi.org/10.3324/haematol.2022.281386

Adverse karyotype subcategories in acute myeloid leukemia display significant differences in mutation composition and transplant-augmented survival (489 Online Views)

Ayalew Tefferi, Amritpal Singh, Naseema Gangat, Aref Al-Kali, Hassan Alkhateeb, Mithun Shah, Mrinal S. Patnaik, Michelle A. Elliott, William J. Hogan, Mark R. Litzow, Alexandra Wolanskyj-Spinner, Christopher C. Hook, Abhishek Mangaonkar, David Viswanatha, Dong Chen, Animesh Pardanani, Kebede H. Begna, Rhett P. Ketterling

https://doi.org/10.3324/haematol.2022.281495

Mitigation of gastrointestinal graft-versus-host disease with tocilizumab prophylaxis is accompanied by preservation of microbial diversity and attenuation of enterococcal domination (1160 Online Views)

Saurabh Chhabra, Aniko Szabo, Annelie Clurman, Katelynn McShane, Nicholas Waters, Daniel Eastwood, Lisa Samanas, Teng Fei, Gabriel Armijo, Sameen Abedin, Walter Longo, Parameswaran Hari, Mehdi Hamadani, Nirav N. Shah, Lyndsey Runaas, James H. Jerkins, Marcel van den Brink, Jonathan U. Peled, William R. Drobyski

https://doi.org/10.3324/haematol.2022.281309

Clinical impact of clonal hematopoiesis on severe COVID- 19 patients without canonical risk factors (886 Online Views)

Chang Kyung Kang, Baekgyu Choi, Sugyeong Kim, Choong Hyun Sun, Soon Ho Yoon, Kyukwang Kim, Euijin Chang, Jongtak Jung, Pyoeng Gyun Choe, Wan Beom Park, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh, Hogune Im, Joohae Kim, Yong Hoon Lee, Jaehee Lee, Hyonho Chun, Youngil Koh, Ji Yeon Lee, Joon Ho Moon, Kyoung-Ho Song, Inkyung Jung

https://doi.org/10.3324/haematol.2022.280621

Von Willebrand factor in the plasma and in the tumor tissue predicts cancer-associated thrombosis and mortality (530 Online Views)

Ioannis Karampinis, Kai Nowak, Julian Koett, Christian Mess, Laura Wagner, Timo Gaiser, Frank Thomas Mayer, Lukas Goertz, Stefan Werner Schneider, Alexander Thomas Bauer

https://doi.org/10.3324/haematol.2022.281315

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B-cell impairment and increases the risk for infections - a retrospective matched cohort study (500 Online Views)

Michael Launspach, Dennis Temel, Emily Ohlendorf, Felix Zirngibl, Bianca Materne, Lena Oevermann, Hedwig E. Deubzer, Anton G. Henssen, Annette Künkele, Patrick Hundsdörfer, Horst von Bernuth, Axel Pruß, Angelika Eggert, Arend von Stackelberg, Peter Lang, Johannes H. Schulte

https://doi.org/10.3324/haematol.2022.281134

Contribution of measurable residual disease status to prediction accuracy of relapse and survival in adults with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation (548 Online Views)

Eduardo Rodríguez-Arbolí, Megan Othus, Corentin Orvain, Lucas C. Zarling, Brenda M. Sandmaier, Filippo Milano, Gary Schoch, Chris Davis, H. Joachim Deeg, Frederick R. Appelbaum, Rainer Storb, Roland B. Walter

https://doi.org/10.3324/haematol.2022.281631

Donor cell-derived myelofibrosis relapse after allogeneic stem cell transplantation (484 Online Views)

Patrizia Chiusolo, Nicoletta Orlando, Sabrina Giammarco, Monica Rossi, Elisabetta Metafuni, Salvatore Leotta, Giuseppe Milone, Caterina Giovanna Valentini, Maria Bianchi, Filippo Frioni, Claudio Pellegrino, Federica Sorà, Luigi Maria Larocca, Simona Sica, Andrea Bacigalupo, Luciana Teofili

https://doi.org/10.3324/haematol.2022.281564

Crosstalk between β-catenin and WT1 signaling activity in acute myeloid leukemia (1109 Online Views)

Megan Wagstaff, Olga Tsaponina, Gilian Caalim, Hayley Greenfield, Leanne Milton-Harris, Erika J. Mancini, Allison Blair, Kate J. Heesom, Alex Tonks, Richard L. Darley, Stefan G. Roberts, Rhys G. Morgan

https://doi.org/10.3324/haematol.2021.280294

Case Reports

Acute myeloid leukemia development soon after anti-CD19 chimeric antigen receptor T-cell infusion in a patient with refractory diffuse large B-cell lymphoma and pre-existing clonal hematopoiesis (1098 Online Views)

Lorenza Falini, Alessandra Venanzi, Valentina Tini, Alessandra Innocente, Stelvio Ballanti, Simonetta Saldi, Silvio Sivolella, Antonio Pierini, Cynthia Aristei, Enrico Tiacci, Vincenzo Maria Perriello, Brunangelo Falini

https://doi.org/10.3324/haematol.2022.281351