Vol. 108 No. 2 (2023): February, 2023

Shinobu Tsuzuki, Takahiko Yasuda, Hiroaki Goto, Naoko Maeda, Koshi Akahane, Takeshi Inukai, Hideyuki Yamamoto, Sivasundaram Karnan, Akinobu Ota, Toshinori Hyodo, Hiroyuki Konishi, Yoshitaka Hosokawa, Hitoshi Kiyoi, Fumihiko Hayakawa

https://doi.org/10.3324/haematol.2022.280879

In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia (2813 Online Views)

Maaike Van Trimpont, Amanda M. Schalk, Yanti De Visser, Hien Anh Nguyen, Lindy Reunes, Katrien Vandemeulebroecke, Evelien Peeters, Ying Su, Hyun Lee, Philip L. Lorenzi, Wai-Kin Chan, Veerle Mondelaers, Barbara De Moerloose, Tim Lammens, Steven Goossens, Pieter Van Vlierberghe, Arnon Lavie

https://doi.org/10.3324/haematol.2022.281390

Relative impact of residual cytogenetic abnormalities and flow cytometric measurable residual disease on outcome after allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia (1644 Online Views)

Corentin Orvain, Jacob A. Wilson, Min Fang, Brenda M. Sandmaier, Eduardo Rodríguez-Arbolí, Brent L. Wood, Megan Othus, Frederick R. Appelbaum, Roland B. Walter

https://doi.org/10.3324/haematol.2022.281585

Early expression of CD94 and loss of CD96 on CD8+ T cells after allogeneic stem cell tranplantation is predictive of subsequent relapse and survival (2161 Online Views)

Kriti Verma, Wayne Croft, Hayden Pearce, Jianmin Zuo, Christine Stephens, Jane Nunnick, Francesca AM Kinsella, Ram Malladi, Paul Moss

https://doi.org/10.3324/haematol.2021.280497

Molecular monitoring of T-cell kinetics and migration in severe neurotoxicity after real-world CD19-specific chimeric antigen receptor T cell therapy (3727 Online Views)

Susanna Carolina Berger, Boris Fehse, Nuray Akyüz, Maria Geffken, Christine Wolschke, Dietlinde Janson, Nico Gagelmann, Marlene Luther, Dominic Wichmann, Christian Frenzel, Guenther Thayssen, Anna Alegiani, Anita Badbaran, Silke Zeschke, Judith Dierlamm, Nicolaus Kröger, Francis A. Ayuk

https://doi.org/10.3324/haematol.2022.281110

Potent preclinical activity of FLT3-directed chimeric antigen receptor T-cell immunotherapy against FLT3- mutant acute myeloid leukemia and KMT2A-rearranged acute lymphoblastic leukemia (4244 Online Views)

Lisa M. Niswander, Zachary T. Graff, Christopher D. Chien, John A. Chukinas, Christina A. Meadows, Lillie C. Leach, Joseph P. Loftus, M. Eric Kohler, Sarah K. Tasian, Terry J. Fry

https://doi.org/10.3324/haematol.2022.281456

Translational readthrough at F8 nonsense variants in the factor VIII B domain contributes to residual expression and lowers inhibitor association (1295 Online Views)

Maria Francesca Testa, Silvia Lombardi, Francesco Bernardi, Mattia Ferrarese, Donata Belvini, Paolo Radossi, Giancarlo Castaman, Mirko Pinotti, Alessio Branchini

https://doi.org/10.3324/haematol.2022.281279

Durable discontinuation of systemic therapy in patients affected by chronic graft-versus-host disease (2657 Online Views)

George L. Chen, Lynn Onstad, Paul J. Martin, Paul Carpenter, Joseph Pidala, Sally Arai, Corey Cutler, Betty K. Hamilton, Stephanie J. Lee, Mukta Arora

https://doi.org/10.3324/haematol.2021.279814

Osteoprogenitor SFRP1 prevents exhaustion of hematopoietic stem cells via PP2A-PR72/130-mediated regulation of p300 (1545 Online Views)

Franziska Hettler, Christina Schreck, Sandra Romero Marquez, Thomas Engleitner, Baiba Vilne, Theresa Landspersky, Heike Weidner, Renate Hausinger, Ritu Mishra, Rupert Oellinger, Martina Rauner, Ronald Naumann, Christian Peschel, Florian Bassermann, Roland Rad, Rouzanna Istvanffy, Robert A.J. Oostendorp

https://doi.org/10.3324/haematol.2022.280760

ARID5B influences B-cell development and function in mouse (1439 Online Views)

Charnise Goodings, Xujie Zhao, Shannon McKinney-Freeman, Hui Zhang, Jun J. Yang

https://doi.org/10.3324/haematol.2022.281157

Serum vascular endothelial growth factor is associated with cardiovascular involvement and response to therapy in Erdheim-Chester disease (1618 Online Views)

Anais Roeser, Marine Bravetti, Lida Dong, Levi-Dan Azoulay, Frederic Charlotte, Makoto Miyara, Pascale Ghillani-Dalbin, Jean-Francois Emile, Fadwa El Kouari, Hamza Ouni, Jean-Marc Lacorte, Isabelle Brocheriou, Zahir Amoura, Fleur Cohen-Aubart, Julien Haroche

https://doi.org/10.3324/haematol.2022.280755

Selective inhibition of MCL1 overcomes venetoclax resistance in a murine model of myelodysplastic syndromes (2135 Online Views)

Melissa A. Fischer, Yuanbin Song, Maria P. Arrate, Rana Gbyli, Matthew T. Villaume, Brianna N. Smith, Merrida A. Childress, Thomas P. Stricker, Stephanie Halene, Michael R. Savona

https://doi.org/10.3324/haematol.2022.280631

High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes (1822 Online Views)

Jennifer Teichman, Michelle Geddes, Nancy Zhu, Mary-Margaret Keating, Mitchell Sabloff, Grace Christou, Brian Leber, Dina Khalaf, Eve St-Hilaire, Nicholas Finn, April Shamy, Karen W.L. Yee, John M. Storring, Thomas J. Nevill, Robert Delage, Mohamed Elemary, Versha Banerji, Brett Houston, Lee Mozessohn, Lisa Chodirker, Liying Zhang, Mohammed Siddiqui, Anne Parmentier, Heather A. Leitch, Rena J. Buckstein

https://doi.org/10.3324/haematol.2022.280723

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas (3410 Online Views)

Cristina Lopez, Nikolai Schleussner, Stephan H. Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L. Sczakiel, Helene Kretzmer, Umut H. Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C. Gonzalez Sanchez, Gordana Apic, Daniel Hubschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M. Muller, Julian Seufert, Steve Hoffmann, Jan O. Korbel, Robert B. Russell, Roland Schule, Lorenz Trumper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kuppers, Matthias Schlesner, Stephan Mathas, Reiner Siebert

https://doi.org/10.3324/haematol.2021.280005

Small-molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy (2239 Online Views)

Uta M. Demel, Matthias Wirth, Schayan Yousefian, Le Zhang, Konstandina Isaakidis, Judith Dönig, Marlitt Böger, Nikita Singh, Hazal Köse, Simon Haas, Stefan Müller, Markus Schick, Ulrich Keller

https://doi.org/10.3324/haematol.2022.280995

All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells (2490 Online Views)

Estefanía García-Guerrero, Luis G. Rodríguez-Lobato, Belén Sierro-Martínez, Sophia Danhof, Stephan Bates, Silke Frenz, Larissa Haertle, Ralph Götz, Markus Sauer, Leo Rasche, K. Martin Kortüm, Jose A. Pérez-Simón, Hermann Einsele, Michael Hudecek, Sabrina R. Prommersberger

https://doi.org/10.3324/haematol.2022.281339

Mutations in the RACGAP1 gene cause autosomal recessive congenital dyserythropoietic anemia type III (1706 Online Views)

Gonzalo Hernández, Lídia Romero-Cortadellas, Xènia Ferrer-Cortès, Veronica Venturi, Mercedes Dessy-Rodriguez, Mireia Olivella, Ammar Husami, Concepción Pérez de Soto, Rosario M. Morales-Camacho, Ana Villegas, Fernando-Ataulfo González-Fernández, Marta Morado, Theodosia A. Kalfa, Oscar Quintana-Bustamante, Santiago Pérez-Montero, Cristian Tornador, Jose-Carlos Segovia, Mayka Sánchez

https://doi.org/10.3324/haematol.2022.281277

Associations between socioeconomic status and bispecific LV20.19 CAR T-cell therapy outcomes (1530 Online Views)

Jennifer M. Knight, Edward Hackett, Aniko Szabo, Ruizhe Wu, Garrett Sauber, Bryon Johnson, Rachel N. Cusatis, Elizabeth Aughey, Steve W. Cole, Cecilia J. Hillard, Nirav N. Shah

https://doi.org/10.3324/haematol.2022.281957

The effects of cardio-selective β blockade on diastolic dysfunction in children with sickle cell disease (840 Online Views)

Parul Rai, Victoria I. Okhomina, Guolian Kang, Nour Akil, Jeffrey A. Towbin, Jane S. Hankins, Gary Beasley

https://doi.org/10.3324/haematol.2022.281428

IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1-positive leukemia cells in preclinical models (1042 Online Views)

Helena Ågerstam, Henrik Lilljebjörn, Marianne Rissler, Carl Sandén, Thoas Fioretos

https://doi.org/10.3324/haematol.2022.281059

Influence of bisphosphonates or recombinant human parathyroid hormone on in vitro sensitivity of acute lymphoblastic leukemia cells to chemotherapy (1349 Online Views)

Demi T.C. de Winter, Jenneke E. van Atteveld, Jessica G.C.A.M. Buijs-Gladiness, Rob Pieters, Sebastian J.C.M.M. Neggers, Jules P.P. Meijerink, Marry M. van den Heuvel-Eibrink

https://doi.org/10.3324/haematol.2022.281033

Impact of daratumumab-based induction on stem cell collection parameters in Swedish myeloma patients (1934 Online Views)

Konstantinos Lemonakis, Love Tatting, Mikael Lisak, Kristina Carlson, Jacob Crafoord, Cecilie H Blimark, Antonio I Santamaria, Stina Wichert, Stig Lenhoff, Markus Hansson

https://doi.org/10.3324/haematol.2022.281610

Cytomegalovirus reactivation after CD19 CAR T-cell therapy is clinically significant (1552 Online Views)

George Chen, Megan Herr, Jan Nowak, Christine Ho, Nikolaos Almyroudis, Kristopher Attwood, John Bonnewell, Marissa Walsh, Brahm Segal, Maureen Ross, Philip McCarthy, Theresa Hahn

https://doi.org/10.3324/haematol.2022.281719

Prognostic value of positron emission tomography/computed tomography in transplant-eligible newly diagnosed multiple myeloma patients from CASSIOPEIA: the CASSIOPET study (2656 Online Views)

Françoise Kraeber-Bodéré, Sonja Zweegman, Aurore Perrot, Cyrille Hulin, Denis Caillot, Thierry Facon, Xavier Leleu, Karim Belhadj, Emmanuel Itti, Lionel Karlin, Clément Bailly, Mark-David Levin, Monique C. Minnema, Bastien Jamet, Caroline Bodet-Milin, Bart de Keizer, Marie C. Béné, Hervé Avet-Loiseau, Pieter Sonneveld, Lixia Pei, Fabio Rigat, Carla de Boer, Jessica Vermeulen, Tobias Kampfenkel, Jérôme Lambert, Philippe Moreau

https://doi.org/10.3324/haematol.2021.280051

A novel SART3::RARG fusion gene in acute myeloid leukemia with acute promyelocytic leukemia phenotype and differentiation escape to retinoic acid (1108 Online Views)

Ji Li, Yang Zhang, Junjun Li, Yunxiao Xu, Guangsen Zhang

https://doi.org/10.3324/haematol.2022.281766

Therapeutic potential of β-lactam ceftriaxone for chronic pain in sickle cell disease (952 Online Views)

Ying He, Xiao Guo, Zaijie Jim Wang

https://doi.org/10.3324/haematol.2022.281716

ADAMTS13 conformation is closed in non-immune acquired thrombotic thrombocytopenic purpura of unidentified pathophysiology (1581 Online Views)

Bérangère S. Joly, Elien Roose, Paul Coppo, Karen Vanhoorelbeke, Agnès Veyradier

https://doi.org/10.3324/haematol.2022.280768

Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation (3108 Online Views)

Annalisa Ruggeri, Liesbeth C. de Wreede, Carlheinz R. Müller, Pietro Crivello, Edouard F. Bonneville, Effie W. Petersdorf, Gerard Socié, Valérie Dubois, Riitta Niittyvuopio, Juha Peräsaari, Ibrahim Yakoub-Agha, Jan J. Cornelissen, Lotte Wieten, Tobias Gedde-Dahl, Edouard Forcade, Charles R. Crawley, Steven G.E. Marsh, Virginie Gandemer, Eleni Tholouli, Claude-Eric Bulabois, Anne Huynh, Goda Choi, Eric Deconinck, Maija Itäla-Remes, Stig Lenhoff, Mats Bengtsson, Jan-Erik Johansson, Gwendolyn van Gorkom, Jorinde D. Hoogenboom, Luca Vago, Vanderson Rocha, Chiara Bonini, Christian Chabannon, Katharina Fleischhauer

https://doi.org/10.3324/haematol.2021.280055