February, 2022
No. 107 (2)

About the Cover

Landmark papers in Hematology

Editorials

Review Articles

Articles

Acute Lymphoblastic Leukemia

Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy (1879 Online Views)

Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling

https://doi.org/10.3324/haematol.2021.278411

Hematopoiesis

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity (3374 Online Views)

Amanda Amoah, Anja Keller, Ramiz Emini, Markus Hoenicka, Andreas Liebold, Angelika Vollmer, Karina Eiwen, Karin Soller, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger

https://doi.org/10.3324/haematol.2020.269670

Acute Myeloid Leukemia

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia (4532 Online Views)

Rudy Birsen, Clement Larrue, Justine Decroocq, Natacha Johnson, Nathan Guiraud, Mathilde Gotanegre, Lilia Cantero-Aguilar, Eric Grignano, Tony Huynh, Michaela Fontenay, Olivier Kosmider, Patrick Mayeux, Nicolas Chapuis, Jean Emmanuel Sarry, Jerome Tamburini, Didier Bouscary

https://doi.org/10.3324/haematol.2020.259531

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells (1237 Online Views)

Orsola di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, John S. Welch

https://doi.org/10.3324/haematol.2021.278603

Cell Therapy & Immunotherapy

Human invariant natural killer T cells promote tolerance by preferential apoptosis induction of conventional dendritic cells (1390 Online Views)

Hannes Schmid, Emmanuelle M. Ribeiro, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Ruoyun Dong, Timo Munz, Klaus Schulze-Osthoff, Stephan Hailfinger, Corina Schneidawind, Dominik Schneidawind

https://doi.org/10.3324/haematol.2020.267583

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide (5033 Online Views)

Mark Gurney, Arwen Stikvoort, Emma Nolan, Lucy Kirkham-McCarthy, Stanislav Khoruzhenko, Rama Shivakumar, Sonja Zweegman, Niels W.C.J. van de Donk, Tuna Mutis, Eva Szegezdi, Subhashis Sarkar, Michael O’Dwyer

https://doi.org/10.3324/haematol.2020.271908

Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic stem cells using a clinically applicable lentiviral vector (2452 Online Views)

Yang Liu, Maria Dahl, Shubhranshu Debnath, Michael Rothe, Emma M. Smith, Tan Hooi Min Grahn, Sarah Warsi, Jun Chen, Johan Flygare, Axel Schambach, Stefan Karlsson

https://doi.org/10.3324/haematol.2020.269142

Complications in Hematology

Long term follow-up of pediatric-onset Evans syndrome: broad immunopathological manifestations and high treatment burden (1622 Online Views)

Thomas Pincez, Helder Fernandes, Thierry Leblanc, Gérard Michel, Vincent Barlogis, Yves Bertrand, Bénédicte Neven, Wadih Abou Chahla, Marlène Pasquet, Corinne Guitton, Aude Marie-Cardine, Isabelle Pellier, Corinne Armari-Alla, Joy Benadiba, Pascale Blouin, Eric Jeziorski, Frédéric Millot, Catherine Paillard, Caroline Thomas, Nathalie Cheikh, Sophie Bayart, Fanny Fouyssac, Christophe Piguet, Marianna Deparis, Claire Briandet, Eric Dore, Capucine Picard, Frédéric Rieux-Laucat, Judith Landman-Parker, Guy Leverger, Nathalie Aladjidi

https://doi.org/10.3324/haematol.2020.271106

Iron Metabolism & its Disorders

Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multi-center nation-wide cohort (1669 Online Views)

Maddalena Casale, Gian Luca Forni, Elena Cassinerio, Daniela Pasquali, Raffaella Origa, Marilena Serra, Saveria Campisi, Angelo Peluso, Roberta Renni, Alessandro Cattoni, Elisa De Michele, Massimo Allò, Maurizio Poggi, Francesca Ferrara, Rosanna Di Concilio, Filomena Sportelli, Antonella Quarta, Maria Caterina Putti, Lucia Dora Notarangelo, Antonella Sau, Saverio Ladogana, Immacolata Tartaglione, Stefania Picariello, Alessia Marcon, Patrizia Sturiale, Domenico Roberti, Antonio Ivan Lazzarino, Silverio Perrotta

https://doi.org/10.3324/haematol.2020.272419

UBA6 and NDFIP1 regulate the degradation of ferroportin (1280 Online Views)

Lisa Traeger, Steffen B. Wiegand, Andrew J. Sauer, Benjamin H.P. Corman, Kathryn M. Peneyra, Florian Wunderer, Anna Fischbach, Aranya Bagchi, Rajeev Malhotra, Warren M. Zapol, Donald B. Bloch

https://doi.org/10.3324/haematol.2021.278530

Non-Hodgkin Lymphoma

Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis (2193 Online Views)

Rachel Dobson, Peter Y. Du, Lívia Rásó-Barnett, Wen-Qing Yao, Zi Chen, Calogero Casa, Hesham EI-Daly, Lorant Farkas, Elizabeth Soilleux, Penny Wright, John W. Grant, Manuel Rodriguez-Justo, George A. Follows, Hala Rashed, Margarete Fabre, E. Joanna Baxter, George Vassiliou, Andrew Wotherspoon, Ayoma D. Attygalle, Hongxiang Liu, Ming-Qing Du

https://doi.org/10.3324/haematol.2020.265991

Efficacy and safety assessment of prolonged maintenance with subcutaneous rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: results of the phase III MabCute study (2100 Online Views)

Simon Rule, Wolney Gois Barreto, Javier Briones, Angelo M. Carella, Olivier Casasnovas, Chris Pocock, Clemens-Martin Wendtner, Francesco Zaja, Susan Robson, Lachlan MacGregor, Roger R. Tschopp, Sonja Nick, Martin Dreyling

https://doi.org/10.3324/haematol.2020.274803

Myeloid Biology

Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia (2267 Online Views)

Eun-Ji Choi, Young-Uk Cho, Eun-Hye Hur, Seongsoo Jang, Nayoung Kim, Han-Seung Park, Jung-Hee Lee, Kyoo-Hyung Lee, Si-Hwan Kim, Sang-Hyun Hwang, Eul-Ju Seo, Chan-Jeoung Park, Je-Hwan Lee

https://doi.org/10.3324/haematol.2020.270553

Platelet Biology & its Disorders

Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates (2189 Online Views)

Martina H. Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Adrian R. Wilkie, Hans Gaus, Jazana M. Goolsby, Ross Okazaki, Brooke E. Terkovich, John W. Semple, Jonathan N. Thon, Scott P. Henry, Padmakumar Narayanan, Joseph E. Italiano Jr.

https://doi.org/10.3324/haematol.2020.260059

Red Cell Biology & its Disorders

Letters to the Editor

SARS-CoV-2 infection in aplastic anemia (1742 Online Views)

Daniele Avenoso, Judith C.W. Marsh, Victoria Potter, Antonio Pagliuca, Simon Slade, Fiona Dignan, Eleni Tholouli, Sajjan Mittal, Bernard Davis, Sudhir Tauro, Rachel Kesse-Adu, Morag Griffin, Elspeth Payne, Shreyans Gandhi, Austin G. Kulasekararaj

https://doi.org/10.3324/haematol.2021.279928

The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells (742 Online Views)

Virginia C Rodriguez-Cortez, Maria Pilar Navarrete-Meneses, Oscar Molina, Talia Velasco-Hernandez, Jessica Gonzalez, Paola Romecin, Francisco Gutierrez-Aguera, Heleia Roca-Ho, Meritxell Vinyoles, Eric Kowarz, Pedro Marin, Sandra Rodriguez-Perales, Carlos Gomez-Marin, Patricia Perez-Vera, Felipe Cortes-Ledesma, Anna Bigas, Andrea Terron, Clara Bueno, Pablo Menendez

https://doi.org/10.3324/haematol.2021.279047

Somatic STAT3 mutations in CD8+ T cells of healthy blood donors carrying human T-cell leukemia virus type 2 (1110 Online Views)

Daehong Kim, Mikko Myllymäki, Matti Kankainen, Timo Jarvinen, Giljun Park, Roberta Bruhn, Edward L. Murphy, Satu Mustjoki

https://doi.org/10.3324/haematol.2021.279140

Incidence and outcome of SARS-CoV-2 infection in patients with monoclonal gammopathy of undetermined significance: a case-control study (959 Online Views)

Nicola Sgherza, Paola Curci, Rita Rizzi, Vanda Strafella, Daniela Di Gennaro, Angelantonio Vitucci, Antonio Palma, Antonella Vita Russo Rossi, Francesco Albano, Pasquale Stefanizzi, Silvio Tafuri, Pellegrino Musto

https://doi.org/10.3324/haematol.2021.279895

Interferon α-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation (913 Online Views)

Seema Bhatlekar, Shancy Jacob, Emilia Tugolukova, Bhanu K. Manne, Yasuhiro Kosaka, Phillipe Loher, Ryan M. O’Connell, Vicente Planelles, Matthew T. Rondina, Isidore Rigoutsos, Paul F. Bray

https://doi.org/10.3324/haematol.2021.279864