Vol. 106 No. 3 (2021): March, 2021

Lesley-Ann Sutton, Viktor Ljungström, Anna Enjuanes, Diego Cortese, Aron Skaftason, Eugen Tausch, Katerina Stano Kozubik, Ferran Nadeu, Marine Armand, Jikta Malcikova, Tatjana Pandzic, Jade Forster, Zadie Davis, David Oscier, Davide Rossi, Paolo Ghia, Jonathan C. Strefford, Sarka Pospisilova, Stephan Stilgenbauer, Frederic Davi, Elias Campo, Kostas Stamatopoulos, Richard Rosenquist, European Research Initiative on CLL (ERIC)

https://doi.org/10.3324/haematol.2019.234716

Stem cell factor is implicated in microenvironmental interactions and cellular dynamics of chronic lymphocytic leukemia (1836 Online Views)

George I. Gavriilidis, Stavroula Ntoufa, Nikos Papakonstantinou, Konstantia Kotta, Triantafyllia Koletsa, Elisavet Chartomatsidou, Theodoros Moysiadis, Niki Stavroyianni, Achilles Anagnostopoulos, Eleni Papadaki, Asterios S. Tsiftsoglou, Kostas Stamatopoulos

https://doi.org/10.3324/haematol.2019.236513

Diagnosis and prognosis are supported by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study (2762 Online Views)

Sophie Vantyghem, Pierre Peterlin, Sylvain Thépot, Audrey Ménard, Viviane Dubruille, Camille Debord, Thierry Guillaume, Alice Garnier, Amandine Le Bourgeois, Soraya Wuilleme, Catherine Godon, Olivier Theisen, Marion Eveillard, Jacques Delaunay, Hervé Maisonneuve, Nadine Morineau, Bruno Villemagne, Stéphane Vigouroux, François Subiger, Elsa Lestang, Marion Loirat, Anne Parcelier, Pascal Godmer, Mélanie Mercier, Adrien Trebouet, Damien Luque Paz, Ronan Le Calloch, Lenaig Le Clech, Céline Bossard, Anne Moreau, Valérie Ugo, Mathilde Hunault, Philippe Moreau, Steven Le Gouill, Patrice Chevallier, Marie C. Béné, Yannick Le Bris

https://doi.org/10.3324/haematol.2019.242677

The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma (2378 Online Views)

Manuel Montesinos-Rongen, Monica Terrao, Caroline May, Katrin Marcus, Ingmar Blümcke, Martin Hellmich, Ralf Küppers, Anna Brunn, Martina Deckert

https://doi.org/10.3324/haematol.2019.242701

Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma (10344 Online Views)

Matias Autio, Suvi-Katri Leivonen, Oscar Brück, Satu Mustjoki, Judit Mészáros Jørgensen, Marja-Liisa Karjalainen-Lindsberg, Klaus Beiske, Harald Holte, Teijo Pellinen, Sirpa Leppä

https://doi.org/10.3324/haematol.2019.243626

Response-adapted therapy with infusional EPOCH chemotherapy plus rituximab in HIV-associated, B-cell non-Hodgkin's lymphoma (3911 Online Views)

Joseph A. Sparano, Jeannette Y. Lee, Lawrence D. Kaplan, Juan Carlos Ramos, Richard F. Ambinder, William Wachsman, David Aboulafia, Ariela Noy, David H. Henry, Lee Ratner, Ethel Cesarman, Amy Chadburn, Ronald Mitsuyasu

https://doi.org/10.3324/haematol.2019.243386

Differential RNA splicing as a potentially important driver mechanism in multiple myeloma (4474 Online Views)

Michael A. Bauer, Cody Ashby, Christopher Wardell, Eileen M. Boyle, Maria Ortiz, Erin Flynt, Anjan Thakurta, Gareth Morgan, Brian A. Walker

https://doi.org/10.3324/haematol.2019.235424

Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells (2682 Online Views)

Ismael Boussaid, Salomé Le Goff, Célia Floquet, Emilie-Fleur Gautier, Anna Raimbault, Pierre-Julien Viailly, Dina Al Dulaimi, Barbara Burroni, Isabelle Dusanter-Fourt, Isabelle Hatin, Patrick Mayeux, Bertrand Cosson, Michaela Fontenay

https://doi.org/10.3324/haematol.2019.239970

Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver (3141 Online Views)

Xiaolin Ma, Yun Li, Yuji Kondo, Huiping Shi, Jingjing Han, Yizhi Jiang, Xia Bai, Stephanie A. Archer-Hartmann, Parastoo Azadi, Changgeng Ruan, Jianxin Fu, Lijun Xia

https://doi.org/10.3324/haematol.2019.225987

Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia (2352 Online Views)

Xin Li, Zi Sheng, Yuanxin Sun, Yuanjian Wang, Miao Xu, Zhiyue Zhang, Hui Li, Linlin Shao, Yanqi Zhang, Jinming Yu, Chunhong Ma, Chengjiang Gao, Ming Hou, Heyu Ni, Jun Peng, Ji Ma, Qi Feng

https://doi.org/10.3324/haematol.2018.204040

Iron deficiency-induced thrombocytosis increases thrombotic tendency in rats (11851 Online Views)

Kristine Jimenez, Florentina Leitner, Aran Leitner, Gisela Scharbert, Philipp Schwabl, Anne-Margarethe Kramer, Anita Krnjic, Joachim Friske, Thomas Helbich, Rayko Evstatiev, Vineeta Khare, Christoph Gasche

https://doi.org/10.3324/haematol.2019.245092

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice (3010 Online Views)

Antonella Nai, Maria Rosa Lidonnici, Giorgia Federico, Mariateresa Pettinato, Violante Olivari, Federica Carrillo, Simonetta Geninatti Crich, Giuliana Ferrari, Clara Camaschella, Laura Silvestri, Francesca Carlomagno

https://doi.org/10.3324/haematol.2019.241232

A role for hepcidin in the anemia caused by Trypanosoma brucei infection (2975 Online Views)

João V. Neves, Ana C. Gomes, David M. Costa, Carolina Barroso, Sophie Vaulont, Anabela Cordeiro da Silva, Joana Tavares, Pedro N.S. Rodrigues

https://doi.org/10.3324/haematol.2019.227728

The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice (2880 Online Views)

Frederik Denorme, Kimberly Martinod, Aline Vandenbulcke, Cécile V. Denis, Peter J. Lenting, Hans Deckmyn, Karen Vanhoorelbeke, Simon F. De Meyer

https://doi.org/10.3324/haematol.2019.241042

CRISPR/Cas9-mediated knockin of human factor IX into swine factor IX locus effectively alleviates bleeding in hemophilia B pigs (3515 Online Views)

Jiahuan Chen, Beiying An, Biao Yu, Xiaohuan Peng, Hongming Yuan, Qiangbing Yang, Xue Chen, Tingting Yu, Lingyu Wang, Xinwei Zhang, He Wang, Xiaodong Zou, Daxin Pang, Hongsheng Ouyang, Xiaochun Tang

https://doi.org/10.3324/haematol.2019.224063

Identification of an immunogenic DKK1 long peptide for immunotherapy of human multiple myeloma (2107 Online Views)

Rong Li, Chengyun Zheng, Qiang Wang, Enguang Bi, Maojie Yang, Jian Hou, Weijun Fu, Qing Yi, Jianfei Qian

https://doi.org/10.3324/haematol.2019.236836

Genome editing of donor-derived T-cells to generate allogenic chimeric antigen receptor-modified T cells: Optimizing αβ T cell-depleted haploidentical hematopoietic stem cell transplantation (4961 Online Views)

Volker Wiebking, Ciaran M. Lee, Nathalie Mostrel, Premanjali Lahiri, Rasmus Bak, Gang Bao, Maria Grazia Roncarolo, Alice Bertaina, Matthew H. Porteus

https://doi.org/10.3324/haematol.2019.233882

Clinical activity of abemaciclib in patients with relapsed or refractory mantle cell lymphoma - a phase II study (2068 Online Views)

Franck Morschhauser, Kamal Bouabdallah, Stephan Stilgenbauer, Catherine Thieblemont, Sophie de Guibert, Florian Zettl, Lawrence M. Gelbert, P. Kellie Turner, Siva Rama Prasad Kambhampati, Li Li, Lily Q. Li, Sean Buchanan, Susana Barriga, Melissa M. Bear, Martin Wilhelm, Georg Hess

https://doi.org/10.3324/haematol.2019.224535

CCND2 mutations are infrequent events in BCR-ABL1 negative myeloproliferative neoplasm patients (1271 Online Views)

Bruno Cassinat, Emmanuelle Verger, Nabih Maslah, Nicolas Gauthier, William Vainchenker, Stéphane Giraudier, Jean-Jacques Kiladjian

https://doi.org/10.3324/haematol.2020.252643

Acute myeloid leukemia shapes the bone marrow stromal niche in vivo (2947 Online Views)

Alice Pievani, Samantha Donsante, Chiara Tomasoni, Alessandro Corsi, Francesco Dazzi, Andrea Biondi, Mara Riminucci, Marta Serafini

https://doi.org/10.3324/haematol.2020.247205

Clinical spectrum and therapeutic management of auto-immune myelofibrosis: a nation-wide study of 30 cases (3192 Online Views)

Philippe Mertz, Emilie Chalayer, Zahir Amoura, Pascal Cathebras, Laurent Chiche, Nathalie Coestedoat, Alban Deroux, Elisabeth Diot, Stéphane Durupt, Emmanuel Forestier, Audrey Gorse, Laurent Hudier, Martin Killian, Olivier Lambotte, Claire Lecomte, Emmanuel Ledoult, Camille Martinez, Alexis Mathian, Anne Sophie Morin, Nicolas Noel, Marc Pineton De Chambrun, Louis Terriou, Jean Sibilia, Jacques-Eric Gottenberg, Anne-Sophie Korganow, Laurent Arnaud, Thierry Martin

https://doi.org/10.3324/haematol.2020.249896

Validation of the revised myeloma comorbidity index and other comorbidity scores in a multicenter German study group multiple myeloma trial (2376 Online Views)

Sandra Maria Dold, Mandy-Deborah Möller, Gabriele Ihorst, Christian Langer, Wolfram Pönisch, Lars-Olof Mügge, Stefan Knop, Johannes Jung, Christine Greil, Ralph Wäsch, Monika Engelhardt

https://doi.org/10.3324/haematol.2020.254235

Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression (1544 Online Views)

Ivan Sloma, Philip Beer, Christophe Desterke, Elizabeth Bulaeva, Misha Bilenky, Annaïck Carles, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G. Turhan, Orianne Wagner-Ballon, Philippe Gaulard, Keith Humphries, Martin Hirst, Connie J. Eaves

https://doi.org/10.3324/haematol.2020.249243

Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia (2742 Online Views)

Marketa Zaliova, Eliska Potuckova, Julius Lukes, Lucie Winkowska, Julia Starkova, Iveta Janotova, Lucie Sramkova, Jan Stary, Jan Zuna, Martin Stanulla, Martin Zimmermann, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert, Gunnar Cario, Jan Trka

https://doi.org/10.3324/haematol.2020.249094

Transfer of stem cell niche-residential regulatory T cells prevents post-irradiation bone marrow injury (1540 Online Views)

Miwako Kakiuchi, Yuichi Hirata, Simon C. Robson, Joji Fujisaki

https://doi.org/10.3324/haematol.2019.221820

Outcomes of relapsed or refractory acute myeloid leukemia after frontline hypomethylating agent and venetoclax regimens (8086 Online Views)

Abhishek Maiti, Caitlin R. Rausch, Jorge E. Cortes, Naveen Pemmaraju, Naval G. Daver, Farhad Ravandi, Guillermo Garcia-Manero, Gautam Borthakur, Kiran Naqvi, Maro Ohanian, Nicholas J. Short, Yesid Alvarado, Tapan M. Kadia, Koichi Takahashi, Musa Yilmaz, Nitin Jain, Steven Kornblau, Guillermo Montalban Bravo, Koji Sasaki, Michael Andreeff, Prithiviraj Bose, Alessandra Ferrajoli, Ghayas C. Issa, Elias J. Jabbour, Lucia Masarova, Philip A. Thompson, Sa Wang, Sergej Konoplev, Sherry A. Pierce, Jing Ning, Wei Qiao, John S. Welch, Hagop M. Kantarjian, Courtney D. DiNardo, Marina Y. Konopleva

https://doi.org/10.3324/haematol.2020.252569

Human platelets are a source of collagen I (1573 Online Views)

Anastasia Kyselova, Sven Zukunft, Deborah Puppe, Ilka Wittig, W. Alexander Mann, Imke Dornauf, Ingrid Fleming, Voahanginirina Randriamboavonjy

https://doi.org/10.3324/haematol.2020.255612

FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression (1624 Online Views)

Man-Hua Liu, Jing Chen, Yun-Sheng Yang, Yin-Qi Wang, Guo-Qiang Chen, Yu Zhang, Ying Huang

https://doi.org/10.3324/haematol.2020.251462

Germline pathogenic variants in transcription factors predisposing to pediatric acute myeloid leukemia: results from the French ELAM02 trial (1613 Online Views)

Laurène Fenwarth, Nicolas Duployez, Alice Marceau-Renaut, Wadih Abou Chahla, Stéphane Ducassou, Virginie Gandemer, Marlène Pasquet, Thierry Leblanc, Pascale Schneider, Carine Domenech, Paul Saultier, Guy Leverger, Hélène Lapillonne, Claude Preudhomme, Arnaud Petit

https://doi.org/10.3324/haematol.2020.248872

Phlebotomy as an efficient long-term treatment of congenital erythropoietic porphyria (2012 Online Views)

Arienne Mirmiran, Antoine Poli, Cecile Ged, Caroline Schmitt, Thibaud Lefebvre, Hana Manceau, Raêd Daher, Boualem Moulouel, Katell Peoc'h, Sylvie Simonin, Jean-Marc Blouin, Jean-Charles Deybach, Gaël Nicolas, Hervé Puy, Emmanuel Richard, Laurent Gouya

https://doi.org/10.3324/haematol.2019.228270