December, 2019
No. 104 (12)

Editorials

Review Articles

Articles

Red Cell Biology & Its Disorders

Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells

Xiaofei Yu, Alexander Azzo, Stephanie M. Bilinovich, Xia Li, Mikhail Dozmorov, Ryo Kurita, Yukio Nakamura, David C. Williams, Gordon D. Ginder

https://doi.org/10.3324/haematol.2018.210963

Genetic disarray follows mutant KLF1-E325K expression in a congenital dyserythropoietic anemia patient

Lilian Varricchio, Antanas Planutis, Deepa Manwani, Julie Jaffray, W. Beau Mitchell, Anna Rita Migliaccio, James J. Bieker

https://doi.org/10.3324/haematol.2018.209858

Myelodysplastic Syndromes

Flow cytometric analysis of neutrophil myeloperoxidase expression in peripheral blood for ruling out myelodysplastic syndromes: a diagnostic accuracy study

Tatiana Raskovalova, Marc G. Berger, Marie-Christine Jacob, Sophie Park, Lydia Campos, Carmen Mariana Aanei, Julie Kasprzak, Bruno Pereira, José Labarère, Jean-Yves Cesbron, Richard Veyrat-Masson

https://doi.org/10.3324/haematol.2018.202275

Myeloproliferative Neoplasms

Clinical outcomes under hydroxyurea treatment in polycythemia vera: a systematic review and meta-analysis

Alberto Ferrari, Alessandra Carobbio, Arianna Masciulli, Arianna Ghirardi, Guido Finazzi, Valerio De Stefano, Alessandro Maria Vannucchi, Tiziano Barbui

https://doi.org/10.3324/haematol.2019.221234

Chronic Myeloid Leukemia

Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second-generation tyrosine kinase inhibitors

Georgios Nteliopoulos, Alexandra Bazeos, Simone Claudiani, Gareth Gerrard, Edward Curry, Richard Szydlo, Mary Alikian, Hui En Foong, Zacharoula Nikolakopoulou, Sandra Loaiza, Jamshid S. Khorashad, Dragana Milojkovic, Danilo Perrotti, Robert Peter Gale, Letizia Foroni, Jane F. Apperley

https://doi.org/10.3324/haematol.2018.200220

Acute Myeloid Leukemia

Chronic Lymphocytic Leukemia

Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells

Carmela Ciardullo, Erhan Aptullahoglu, Laura Woodhouse, Wei-Yu Lin, Jonathan P Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec

https://doi.org/10.3324/haematol.2018.206631

Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

Miroslav Boudny, Jana Zemanova, Prashant Khirsariya, Marek Borsky, Jan Verner, Jana Cerna, Alexandra Oltova, Vaclav Seda, Marek Mraz, Josef Jaros, Zuzana Jaskova, Michaela Spunarova, Yvona Brychtova, Karel Soucek, Stanislav Drapela, Marie Kasparkova, Jiri Mayer, Kamil Paruch, Martin Trbusek

https://doi.org/10.3324/haematol.2018.203430

Plasma Cell Disorders

Immune marker changes and risk of multiple myeloma: a nested case-control study using repeated pre-diagnostic blood samples

Florentin Späth, Carl Wibom, Esmeralda J. M. Krop, Antonio Izarra Santamaria, Ann-Sofie Johansson, Ingvar A. Bergdahl, Johan Hultdin, Roel Vermeulen, Beatrice Melin

https://doi.org/10.3324/haematol.2019.216895

Functional interplay between NF-κB-inducing kinase and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma

Laura Mazzera, Manuela Abeltino, Guerino Lombardi, Anna Maria Cantoni, Roberto Ria, Micaela Ricca, Ilaria Saltarella, Valeria Naponelli, Federica Maria Angela Rizzi, Roberto Perris, Attilio Corradi, Angelo Vacca, Antonio Bonati, Paolo Lunghi

https://doi.org/10.3324/haematol.2018.208280

Platelet Biology & its Disorders

Platelet HIF-2α promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release

Susheel N. Chaurasia, Geeta Kushwaha, Paresh P. Kulkarni, Ram L. Mallick, Nazmy A. Latheef, Jai K. Mishra, Debabrata Dash

https://doi.org/10.3324/haematol.2019.217463

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence

Annabelle Dupont, Christelle Soukaseum, Mathilde Cheptou, Frédéric Adam, Thomas Nipoti, Marc-Damien Lourenco-Rodrigues, Paulette Legendre, Valérie Proulle, Antoine Rauch, Charlotte Kawecki, Marijke Bryckaert, Jean-Philippe Rosa, Camille Paris, Catherine Ternisien, Pierre Boisseau, Jenny Goudemand, Delphine Borgel, Dominique Lasne, Pascal Maurice, Peter J. Lenting, Cécile V. Denis, Sophie Susen, Alexandre Kauskot

https://doi.org/10.3324/haematol.2018.206250

Hemostasis

Impact of hypertensive emergency and rare complement variants on the presentation and outcome of atypical hemolytic uremic syndrome

Khalil El Karoui, Idris Boudhabhay, Florent Petitprez, Paula Vieira-Martins, Fadi Fakhouri, Julien Zuber, Florence Aulagnon, Marie Matignon, Eric Rondeau, Laurent Mesnard, Jean-Michel Halimi, Véronique Frémeaux-Bacchi

https://doi.org/10.3324/haematol.2019.216903

Coagulation & Its Disorders

Incidence and features of thrombosis in children with inherited antithrombin deficiency

Belén de la Morena-Barrio, Christelle Orlando, María Eugenia de la Morena-Barrio, Vicente Vicente, Kristin Jochmans, Javier Corral

https://doi.org/10.3324/haematol.2018.210666

Interleukin-17/Interleukin-21 and Interferon-γ producing T cells specific for β2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome

Marisa Benagiano, Maria Orietta Borghi, Jacopo Romagnoli, Michael Mahler, Chiara Della Bella, Alessia Grassi, Nagaja Capitani, Giacomo Emmi, Arianna Troilo, Elena Silvestri, Lorenzo Emmi, Heba Alnwaisri, Jacopo Bitetti, Simona Tapinassi, Domenico Prisco, Cosima Tatiana Baldari, Pier Luigi Meroni, Mario Milco D’Elios

https://doi.org/10.3324/haematol.2018.209536

Guidelines

Chimeric antigen receptor T-cell therapy for multiple myeloma: a consensus statement from The European Myeloma Network

Philippe Moreau, Pieter Sonneveld, Mario Boccadoro, Gordon Cook, Ma Victoria Mateos, Hareth Nahi, Hartmut Goldschmidt, Meletios A. Dimopoulos, Paulo Lucio, Joan Bladé, Michel Delforge, Roman Hajek, Heinz Ludwig, Thierry Facon, Jesus F. San Miguel, Hermann Einsele

https://doi.org/10.3324/haematol.2019.224204

Online Only Articles

Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease

Barbara Cappelli, Fernanda Volt, Karina Tozatto-Maio, Graziana Maria Scigliuolo, Alina Ferster, Sophie Dupont, Belinda Pinto Simões, Amal Al-Seraihy, Mahmoud D. Aljurf, Fahad Almohareb, Cristina Belendez, Susanne Matthes, Nathalie Dhedin, Corinne Pondarre, Jean-Hugues Dalle, Yves Bertrand, Jean Pierre Vannier, Mathieu Kuentz, Patrick Lutz, Gérard Michel, Hanadi Rafii, Benedicte Neven, Marco Zecca, Peter Bader, Marina Cavazzana, Myriam Labopin, Franco Locatelli, Alessandra Magnani, Annalisa Ruggeri, Vanderson Rocha, Françoise Bernaudin, Josu de La Fuente, Selim Corbacioglu, Eliane Gluckman

https://doi.org/10.3324/haematol.2019.216788

The non-erythroid myeloblast count rule in myelodysplastic syndromes: fruitful or futile?

Margot F. van Spronsen, Theresia M. Westers, Birgit I. Lissenberg-Witte, Mariëlle Wondergem, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht

https://doi.org/10.3324/haematol.2018.212563

Results from HARMONY: an open-label, multicenter, 2-arm, phase 1b, dose-finding study assessing the safety and efficacy of the oral combination of ruxolitinib and buparlisib in patients with myelofibrosis

Simon T. Durrant, Arnon Nagler, Paola Guglielmelli, David Lavie, Philipp le Coutre, Heinz Gisslinger, Charles Chuah, Margherita Maffioli, Savita Bharathy, Tuochuan Dong, Monika Wroclawska, Joaquin Martinez Lopez

https://doi.org/10.3324/haematol.2018.209965

Myeloablative conditioning using timed-sequential busulfan plus fludarabine in older patients with acute myeloid leukemia: long-term results of a prospective phase II clinical trial

Rohtesh S. Mehta, Roland Bassett, Amanda Olson, Julianne Chen, Sairah Ahmed, Amin M. Alousi, Paolo Anderlini, Gheath Al-Atrash, Qaiser Bashir, Stefan O. Ciurea, Chitra M. Hosing, Jin S. Im, Partow Kebriaei, Issa Khouri, David Marin, Jeffrey J. Molldrem, Yago Nieto, Betul Oran, Katayoun Rezvani, Muzaffar H. Qazilbash, Samer A. Srour, Elizabeth J. Shpall, Borje S. Andersson, Richard E. Champlin, Uday R. Popat

https://doi.org/10.3324/haematol.2018.214429

Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses

Luciano Cascione, Andrea Rinaldi, Alessio Bruscaggin, Chiara Tarantelli, Alberto J. Arribas, Ivo Kwee, Lorenza Pecciarini, Afua A. Mensah, Valeria Spina, Elaine Y.L. Chung, Lodovico Terzi di Bergamo, Stephan Dirnhofer, Alexandar Tzankov, Roberto N. Miranda, Ken H. Young, Alexandra Traverse-Glehen, Gianluca Gaidano, Steven H. Swerdlow, Randy Gascoyne, Raul Rabadan, Maurilio Ponzoni, Govind Bhagat, Davide Rossi, Emanuele Zucca, Francesco Bertoni

https://doi.org/10.3324/haematol.2018.214957

ALK-positive anaplastic large-cell lymphoma in adults: an individual patient data pooled analysis of 263 patients

David Sibon, Dinh-Phong Nguyen, Norbert Schmitz, Ritsuro Suzuki, Andrew L. Feldman, Rémy Gressin, Laurence Lamant, Dennis D. Weisenburger, Andreas Rosenwald, Shigeo Nakamura, Marita Ziepert, Matthew J. Maurer, Martin Bast, James O. Armitage, Julie M. Vose, Hervé Tilly, Jean-Philippe Jais, Kerry J. Savage

https://doi.org/10.3324/haematol.2018.213512

Molecular remissions are observed in chronic adult T-cell leukemia/lymphoma in patients treated with mogamulizumab

Lucy B. M. Cook, Maria Antonietta Demontis, Sophie Sagawe, Aviva Witkover, Anat Melamed, Jocelyn Turpin, Richard Dillon, Jana Haddow, Alexandra J. Marks, Charles R. M. Bangham, Paul Fields, Graham P. Taylor, Aileen G. Rowan

https://doi.org/10.3324/haematol.2019.219253

Focusing of the regulatory T-cell repertoire after allogeneic stem cell transplantation indicates protection from graft-versus-host disease

Ivan Odak, Solaiman Raha, Christian Schultze-Florey, Saleh Tavil, Sarina Ravens, Arnold Ganser, Reinhold Förster, Immo Prinz, Christian Koenecke

https://doi.org/10.3324/haematol.2019.218206

Case Report

Kikuchi-Fujimoto disease and breast implants: is there a relationship?

Valentina Sangiorgio, Luis Veloza, Karen Galvis, Mónica López, Gerard Frigola, Elias Campo, Olga Balagué

https://doi.org/10.3324/haematol.2019.229831

Comments

The role of nuclear receptor co-activator 4 in erythropoiesis (Reply to Nai et al.)

Naiara Santana-Codina, Sebastian Gableske, Mark D. Fleming, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias

https://doi.org/10.3324/haematol.2019.235226