November, 2019
No. 104 (11)

Editorials

Review Articles

Articles

Hematopoiesis

A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche

Lijian Shao, Kilian Sottoriva, Karol Palasiewicz, Jizhou Zhang, James Hyun, Sweta S. Soni, Na Yoon Paik, Xiaopei Gao, Henar Cuervo, Asrar B. Malik, Jalees Rehman, Daniel Lucas, Kostandin V. Pajcini

https://doi.org/10.3324/haematol.2018.208660

Red Cell Biology & Its Disorders

Deubiquitylase USP7 regulates human terminal erythroid differentiation by stabilizing GATA1

Long Liang, Yuanliang Peng, Jieying Zhang, Yibin Zhang, Mridul Roy, Xu Han, Xiaojuan Xiao, Shuming Sun, Hong Liu, Ling Nie, Yijin Kuang, Zesen Zhu, Jinghui Deng, Yang Xia, Vijay G. Sankaran, Christopher D. Hillyer, Narla Mohandas, Mao Ye, Xiuli An, Jing Liu

https://doi.org/10.3324/haematol.2018.206227

Altered parasite life-cycle processes characterize Babesia divergens infection in human sickle cell anemia

Jeny R. Cursino-Santos, Manpreet Singh, Eric Senaldi, Deepa Manwani, Karina Yazdanbakhsh, Cheryl A. Lobo

https://doi.org/10.3324/haematol.2018.214304

Myeloproliferative Neoplasms

Chronic Myeloid Leukemia

MR4 sustained for 12 months is associated with stable deep molecular responses in chronic myeloid leukemia

Simone Claudiani, Aoife Gatenby, Richard Szydlo, George Nesr, Adi Shacham Abulafia, Renuka Palanicawandar, Georgios Nteliopoulos, Jamshid Khorashad, Letizia Foroni, Jane F. Apperley, Dragana Milojkovic

https://doi.org/10.3324/haematol.2018.214809

Acute Myeloid Leukemia

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation

Cristina Di Genua, Ruggiero Norfo, Alba Rodriguez-Meira, Wei Xiong Wen, Roy Drissen, Christopher A.G. Booth, Benjamin Povinelli, Emmanouela Repapi, Nicki Gray, Joana Carrelha, Laura M. Kettyle, Lauren Jamieson, Wen Hao Neo, Supat Thongjuea, Claus Nerlov, Adam J. Mead

https://doi.org/10.3324/haematol.2018.205351

Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia

Xinyu Li, Yongwei Su, Gerard Madlambayan, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jun Ma, Tristan Knight, Guan Wang, Yue Wang, Jay Yang, Jeffrey W. Taub, Hai Lin, Yubin Ge

https://doi.org/10.3324/haematol.2018.201343

Non-Hodgkin Lymphoma

Prolonged survival in the absence of disease-recurrence in advanced-stage follicular lymphoma following chemo-immunotherapy: 13-year update of the prospective, multicenter randomized GITMO-IIL trial

Riccardo Bruna, Fabio Benedetti, Carola Boccomini, Caterina Patti, Anna Maria Barbui, Alessandro Pulsoni, Maurizio Musso, Anna Marina Liberati, Guido Gini, Claudia Castellino, Fausto Rossini, Fabio Ciceri, Delia Rota-Scalabrini, Caterina Stelitano, Francesco Di Raimondo, Alessandra Tucci, Liliana Devizzi, Valerio Zoli, Francesco Zallio, Franco Narni, Alessandra Dondi, Guido Parvis, Gianpietro Semenzato, Francesco Lanza, Tommasina Perrone, Francesco Angrilli, Atto Billio, Angela Gueli, Barbara Mantoan, Alessandro Rambaldi, Alessandro Massimo Gianni, Paolo Corradini, Roberto Passera, Marco Ladetto, Corrado Tarella

https://doi.org/10.3324/haematol.2018.209932

Chronic Lymphocytic Leukemia

High prognostic value of measurable residual disease detection by flow cytometry in chronic lymphocytic leukemia patients treated with front-line fludarabine, cyclophosphamide, and rituximab, followed by three years of rituximab maintenance

José A. García-Marco, Javier López Jiménez, Valle Recasens, Miguel Fernández Zarzoso, Eva González-Barca, Nieves Somolinos De Marcos, M. Jose Ramírez, Francisco Javier Peñalver Parraga, Lucrecia Yañez, Javier De La Serna Torroba, Maria Dolores Garcia Malo, Guillermo Deben Ariznavarreta, Ernesto Perez Persona, M. Angeles Ruiz Guinaldo, Raquel De Paz Arias, Elena Bañas Llanos, Isidro Jarque, M. del Carmen Fernandez Valle, Ana Carral Tatay, Jaime Perez De Oteyza, Eva Maria Donato Martin, Inmaculada Perez Fernández, Rafael Martinez Martinez, M. Angeles Andreu Costa, Diana Champ, Julio García Suarez, Marcos González Díaz, Secundino Ferrer, Félix Carbonell, José A. García-Vela

https://doi.org/10.3324/haematol.2018.204891

Utility of positron emission tomography-computed tomography in patients with chronic lymphocytic leukemia following B-cell receptor pathway inhibitor therapy

Anthony R. Mato, William G. Wierda, Matthew S. Davids, Bruce D. Cheson, Steven E. Coutre, Michael Choi, Richard R. Furman, Leonard Heffner, Paul M. Barr, Herbert Eradat, Sharanya M. Ford, Lang Zhou, Maria Verdugo, Rod A. Humerickhouse, Jalaja Potluri, John C. Byrd

https://doi.org/10.3324/haematol.2018.207068

Plasma Cell Disorders

Phase II study of carfilzomib, thalidomide, and low-dose dexamethasone as induction and consolidation in newly diagnosed, transplant eligible patients with multiple myeloma; the Carthadex trial

Ruth Wester, Bronno van der Holt, Emelie Asselbergs, Sonja Zweegman, Marie Jose Kersten, Edo Vellenga, Marinus van Marwijk Kooy, Okke de Weerdt, Monique Minnema, Sarah Lonergan, Antonio Palumbo, Henk Lokhorst, Annemiek Broijl, Pieter Sonneveld

https://doi.org/10.3324/haematol.2018.205476

Bortezomib-based induction followed by stem cell transplantation in light chain amyloidosis: results of the multicenter HOVON 104 trial

Monique C. Minnema, Kazem Nasserinejad, Bouke Hazenberg, Ute Hegenbart, Philip Vlummens, Paula F. Ypma, Nicolaus Kröger, Ka Lung Wu, Marie Jose Kersten, M. Ron Schaafsma, Sandra Croockewit, Esther de Waal, Sonja Zweegman, Lidwien Tick, Annemieke Broijl, Harry Koene, Gerard Bos, Pieter Sonneveld, Stefan Schönland

https://doi.org/10.3324/haematol.2018.213900

Platelet Biology & its Disorders

Long-term treatment with romiplostim and treatment-free platelet responses in children with chronic immune thrombocytopenia

Michael D. Tarantino, James B. Bussel, Victor S. Blanchette, Donald Beam, John Roy, Jenny Despotovic, Ashok Raj, Nancy Carpenter, Bhakti Mehta, Melissa Eisen

https://doi.org/10.3324/haematol.2018.202283

Differences and similarities in the effects of ibrutinib and acalabrutinib on platelet functions

Jennifer Series, Cédric Garcia, Marie Levade, Julien Viaud, Pierre Sié, Loïc Ysebaert, Bernard Payrastre

https://doi.org/10.3324/haematol.2018.207183

Hemostasis

Dynamic prediction of bleeding risk in thrombocytopenic preterm neonates

Susanna F. Fustolo-Gunnink, Karin Fijnvandraat, Hein Putter, Isabelle M. Ree, Camila Caram-Deelder, Peter Andriessen, Esther J. d’Haens, Christian V. Hulzebos, Wes Onland, André A. Kroon, Daniël C. Vijlbrief, Enrico Lopriore, Johanna G. van der Bom

https://doi.org/10.3324/haematol.2018.208595

Coagulation & Its Disorders

Stem Cell Transplantation

Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation

Pietro Merli, Ignazio Caruana, Rita De Vito, Luisa Strocchio, Gerrit Weber, Francesca Del Bufalo, Vanessa Buatois, Paolo Montanari, Maria Giuseppina Cefalo, Angela Pitisci, Mattia Algeri, Federica Galaverna, Concetta Quintarelli, Valentina Cirillo, Daria Pagliara, Walter Ferlin, Maria Ballabio, Cristina De Min, Franco Locatelli

https://doi.org/10.3324/haematol.2019.216101

Guidelines

Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after hematopoietic stem cell transplantation

Katherine N Ward, Joshua A Hill, Petr Hubacek, Rafael de la Camara, Roberto Crocchiolo, Hermann Einsele, David Navarro, Christine Robin, Catherine Cordonnier, Per Ljungman

https://doi.org/10.3324/haematol.2019.223073

Online Only Articles

Clinical and morphological predictors of outcome in older aplastic anemia patients treated with eltrombopag

Bruno Fattizzo, Austin G. Kulasekararaj, Anita Hill, Nana Benson-Quarm, Morag Griffin, Talha Munir, Louise Arnold, Kathryn Riley, Robin Ireland, Hugues De Lavallade, Victoria Potter, Dario Consonni, Peter Hillmen, Ghulam J. Mufti, Wilma Barcellini, Judith C. W. Marsh

https://doi.org/10.3324/haematol.2019.216374

Correction of IVS I-110(G>A) β-thalassemia by CRISPR/Cas-and TALEN-mediated disruption of aberrant regulatory elements in human hematopoietic stem and progenitor cells

Petros Patsali, Giandomenico Turchiano, Panayiota Papasavva, Marianna Romito, Constantinos C. Loucari, Coralea Stephanou, Soteroulla Christou, Maria Sitarou, Claudio Mussolino, Tatjana I. Cornu, Michael N. Antoniou, Carsten W. Lederer, Toni Cathomen, Marina Kleanthous

https://doi.org/10.3324/haematol.2018.215178

Autoimmunity associated with Erdheim-Chester disease improves with BRAF/MEK inhibitors

Anaïs Roeser, Fleur Cohen-Aubart, Paul Breillat, Makoto Miyara, Jean-François Emile, Frédéric Charlotte, Jean Donadieu, Zahir Amoura, Julien Haroche

https://doi.org/10.3324/haematol.2018.214007

Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy

Yasutaka Fukuda, Marito Araki, Kouji Yamamoto, Soji Morishita, Tadaaki Inano, Kyohei Misawa, Tomonori Ochiai, Yoko Edahiro, Misa Imai, Hajime Yasuda, Akihiko Gotoh, Akimichi Ohsaka, Norio Komatsu

https://doi.org/10.3324/haematol.2018.208876

Response assessment in acute myeloid leukemia by flow cytometry supersedes cytomorphology at time of aplasia, amends cases without molecular residual disease marker and serves as an independent prognostic marker at time of aplasia and post-induction

Thomas Köhnke, Veit Bücklein, Sandra Rechkemmer, Stephanie Schneider, Maja Rothenberg-Thurley, Klaus H. Metzeler, Maria-Cristina Sauerland, Wolfgang Hiddemann, Karsten Spiekermann, Marion Subklewe

https://doi.org/10.3324/haematol.2018.215236

Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology

Amalie B. Nielsen, Mi Zhou, Adam J. de Smith, Rong Wang, Lucie McCoy, Helen Hansen, Libby Morimoto, Kirsten Grønbæk, Christoffer Johansen, Scott C. Kogan, Catherine Metayer, Paige M. Bracci, Xiaomei Ma, Joseph L. Wiemels

https://doi.org/10.3324/haematol.2019.216465

Impact of corticosteroid pretreatment in pediatric patients with newly diagnosed B-lymphoblastic leukemia: a report from the Children’s Oncology Group

Elizabeth A. Raetz, Mignon L. Loh, Meenakshi Devidas, Kelly Maloney, Leonard A. Mattano, Eric Larsen, Andrew Carroll, Nyla A. Heerema, Julie M. Gastier-Foster, Brent Wood, Michael J. Borowitz, Naomi Winick, Stephen P. Hunger, William L. Carroll

https://doi.org/10.3324/haematol.2018.215616

PD-1 blockade as bridge to allogeneic stem cell transplantation in relapsed/refractory Hodgkin lymphoma patients: a retrospective single center case series

Beatrice Casadei, Alessandro Broccoli, Vittorio Stefoni, Cinzia Pellegrini, Miriam Marangon, Alice Morigi, Laura Nanni, Ginevra Lolli, Matteo Carella, Lisa Argnani, Michele Cavo, Pier Luigi Zinzani

https://doi.org/10.3324/haematol.2019.215962

Variation of rs3754689 at lactase gene and inhibitors in admixed Brazilian patients with hemophilia A

Luciana W. Zuccherato, Silvana M. Elói-Santos, Letícia L. Jardim, Ricardo M. Camelo, Daniel G. Chaves, Renan P. Souza, Edward J. Hollox, Suely M. Rezende

https://doi.org/10.3324/haematol.2019.220608

Case Report

Erdheim-Chester disease associated with chronic myelomonocytic leukemia harboring the same clonal mutation

Pauline Bonnet, François Chasset, Philippe Moguelet, Noémie Abisror, Raphaël Itzykson, Jean-David Bouaziz, Pierre Hirsch, Annick Barbaud, Julien Haroche, Arsène Mekinian, Zofia Hélias-Rodzewicz, Emmanuelle Clappier, Pierre Fenaux, Olivier Fain, Abdellatif Tazi, Jean-François Emile

https://doi.org/10.3324/haematol.2019.223552

ALK-positive histiocytosis with KIF5B-ALK fusion in an adult female

Gaurav K. Gupta, Liqiang Xi, Svetlana D. Pack, Jennifer B. Jones, Stefania Pittaluga, Mark Raffeld, Elaine S. Jaffe

https://doi.org/10.3324/haematol.2019.230094

Clonally related duodenal-type follicular lymphoma and in situ follicular neoplasia

Dominik Nann, Irina Bonzheim, Inga Müller, Barbara Mankel, Leticia Quintanilla-Martínez, Bence Sipos, Falko Fend

https://doi.org/10.3324/haematol.2019.226142

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