April, 2019
No. 104 (4)

Editorials

THROMBOTECT takes the lead

Christoph Male, Sarah H. O’Brien, Lesley Mitchell

https://doi.org/10.3324/haematol.2018.209528

Perspective Articles

Liquid biopsy in lymphoma

Davide Rossi, Valeria Spina, Alessio Bruscaggin, Gianluca Gaidano

https://doi.org/10.3324/haematol.2018.206177

Review Articles

State-of-the-art review: allogeneic stem cell transplantation for myelofibrosis in 2019

Donal P. McLornan, Ibrahim Yakoub-Agha, Marie Robin, Yves Chalandon, Claire N. Harrison, Nicolaus Kroger

https://doi.org/10.3324/haematol.2018.206151

Articles

Hematopoiesis

Iron Metabolism & Its Disorders

Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess

Courtney J. Mercadante, Milankumar Prajapati, Jignesh H. Parmar, Heather L. Conboy, Miriam E. Dash, Michael A. Pettiglio, Carolina Herrera, Julia T. Bu, Edward G. Stopa, Pedro Mendes, Thomas B. Bartnikas

https://doi.org/10.3324/haematol.2018.198382

Red Cell Biology & Its Disorders

Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease

Lena Václavů, Benoit N. Meynart, Henri J.M.M. Mutsaerts, Esben Thade Petersen, Charles B.L.M. Majoie, Ed T. VanBavel, John C. Wood, Aart J. Nederveen, Bart J. Biemond

https://doi.org/10.3324/haematol.2018.206094

Myelodysplastic Syndromes

Azacitidine with or without lenalidomide in higher risk myelodysplastic syndrome & low blast acute myeloid leukemia

Melita Kenealy, Mark Hertzberg, Warwick Benson, Kerry Taylor, Ilona Cunningham, Will Stevenson, Devendra Hiwase, Richard Eek, Daniela Zantomio, Steve Jong, Meaghan Wall, Piers Blombery, Tracey Gerber, Marlyse Debrincat, Diana Zannino, John F. Seymour

https://doi.org/10.3324/haematol.2018.201152

Myeloproliferative Neoplasms

The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14

Beatrice Drexler, Jakob R. Passweg, Alexandar Tzankov, Martin Bigler, Alexandre PA Theocharides, Nathan Cantoni, Peter Keller, Georg Stussi, Axel Ruefer, Rudolf Benz, Geneviève Favre, Pontus Lundberg, Ronny Nienhold, Andrea Fuhrer, Christine Biaggi, Markus G. Manz, Mario Bargetzi, Simon Mendez-Ferrer, Radek C. Skoda

https://doi.org/10.3324/haematol.2018.200014

Chronic Myeloid Leukemia

A new BCR-ABL1 Drosophila model as a powerful tool to elucidate the pathogenesis and progression of chronic myeloid leukemia

Roberto Bernardoni, Giorgia Giordani, Elisabetta Signorino, Sara Monticelli, Francesca Messa, Monica Pradotto, Valentina Rosso, Enrico Bracco, Angela Giangrande, Giovanni Perini, Giuseppe Saglio, Daniela Cilloni

https://doi.org/10.3324/haematol.2018.198267

Myeloid Neoplasms

Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target

Maria Rosaria Sapienza, Francesco Abate, Federica Melle, Stefania Orecchioni, Fabio Fuligni, Maryam Etebari, Valentina Tabanelli, Maria Antonella Laginestra, Alessandro Pileri, Giovanna Motta, Maura Rossi, Claudio Agostinelli, Elena Sabattini, Nicola Pimpinelli, Mauro Truni, Brunangelo Falini, Lorenzo Cerroni, Giovanna Talarico, Rossana Piccioni, Stefano Amente, Valentina Indio, Giuseppe Tarantino, Francesco Brundu, Marco Paulli, Emilio Berti, Fabio Facchetti, Gaetano Ivan Dellino, Francesco Bertolini, Claudio Tripodo, Raul Rabadan, Stefano A. Pileri

https://doi.org/10.3324/haematol.2018.202093

Acute Lymphoblastic Leukemia

Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Roel Polak, Marc B. Bierings, Cindy S. van der Leije, Mathijs A. Sanders, Onno Roovers, João R. M. Marchante, Judith M. Boer, Jan J. Cornelissen, Rob Pieters, Monique L. den Boer, Miranda Buitenhuis

https://doi.org/10.3324/haematol.2018.193631

CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia

Evgeniya Angelova, Charlene Audette, Yelena Kovtun, Naval Daver, Sa A. Wang, Sherry Pierce, Sergej N. Konoplev, Haitham Khogeer, Jeffrey L. Jorgensen, Marina Konopleva, Patrick A. Zweidler-McKay, L. Jeffrey Medeiros, Hagop M. Kantarjian, Elias J. Jabbour, Joseph D. Khoury

https://doi.org/10.3324/haematol.2018.205252

THROMBOTECT – a randomized study comparing low molecular weight heparin, antithrombin and unfractionated heparin for thromboprophylaxis during induction therapy of acute lymphoblastic leukemia in children and adolescents

Jeanette Greiner, Martin Schrappe, Alexander Claviez, Martin Zimmermann, Charlotte Niemeyer, Reinhard Kolb, Wolfgang Eberl, Frank Berthold, Eva Bergsträsser, Astrid Gnekow, Elisabeth Lassay, Peter Vorwerk, Melchior Lauten, Axel Sauerbrey, Johannes Rischewski, Andreas Beilken, Günter Henze, Wolfgang Korte, Anja Möricke, for the THROMBOTECT Study Investigators

https://doi.org/10.3324/haematol.2018.194175

Non-Hodgkin Lymphoma

TIRAP p.R81C is a novel lymphoma risk variant which enhances cell proliferation via NF-κB mediated signaling in B-cells

Regula Burkhard, Irene Keller, Miroslav Arambasic, Darius Juskevicius, Alexandar Tzankov, Pontus Lundberg, Rémy Bruggmann, Stephan Dirnhofer, Ramin Radpour, Urban Novak

https://doi.org/10.3324/haematol.2018.201590

Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma

Clara Recasens-Zorzo, Teresa Cardesa-Salzmann, Paolo Petazzi, Laia Ros-Blanco, Anna Esteve-Arenys, Guillem Clot, Martina Guerrero-Hernández, Vanina Rodríguez, Davide Soldini, Alexandra Valera, Alexandra Moros, Fina Climent, Eva González-Barca, Santiago Mercadal, Leonor Arenillas, Xavier Calvo, José Luís Mate, Gonzalo Gutiérrez-García, Isolda Casanova, Ramón Mangues, Alejandra Sanjuan-Pla, Clara Bueno, Pablo Menéndez, Antonio Martínez, Dolors Colomer, Roger Estrada Tejedor, Jordi Teixidó, Elias Campo, Armando López-Guillermo, José Ignacio Borrell, Luis Colomo, Patricia Pérez-Galán, Gaël Roué

https://doi.org/10.3324/haematol.2017.180505

Chronic Lymphocytic Leukemia

Deep targeted sequencing of TP53 in chronic lymphocytic leukemia: clinical impact at diagnosis and at time of treatment

Christian Brieghel, Savvas Kinalis, Christina W. Yde, Ane Y. Schmidt, Lars Jønson, Michael A. Andersen, Caspar da Cunha-Bang, Lone B. Pedersen, Christian H. Geisler, Finn C. Nielsen, Carsten U. Niemann

https://doi.org/10.3324/haematol.2018.195818

First-line therapy in chronic lymphocytic leukemia: a Swedish nation-wide real-world study on 1053 consecutive patients treated between 2007 and 2013

Sandra Eketorp Sylvan, Anna Asklid, Hemming Johansson, Jenny Klintman, Jenny Bjellvi, Staffan Tolvgård, Eva Kimby, Stefan Norin, Per-Ola Andersson, Claes Karlsson, Karin Karlsson, Birgitta Lauri, Mattias Mattsson, Anna Bergendahl Sandstedt, Maria Strandberg, Anders Österborg, Lotta Hansson

https://doi.org/10.3324/haematol.2018.200204

Platelet Biology & its Disorders

Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents

Paresh P. Kulkarni, Arundhati Tiwari, Nitesh Singh, Deepa Gautam, Vijay K. Sonkar, Vikas Agarwal, Debabrata Dash

https://doi.org/10.3324/haematol.2018.205724

Coagulation & Its Disorders

New insight into antiphospholipid syndrome: antibodies to β2glycoprotein I-domain 5 fail to induce thrombi in rats

Paolo Durigutto, Claudia Grossi, Maria Orietta Borghi, Paolo Macor, Francesca Pregnolato, Elena Raschi, Michael P. Myers, Philip G. de Groot, Pier Luigi Meroni, Francesco Tedesco

https://doi.org/10.3324/haematol.2018.198119

Stem Cell Transplantation

Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation

Aleksandar Radujkovic, Hao Dai, Lambros Kordelas, Dietrich Beelen, Sivaramakrishna P. Rachakonda, Carsten Müller-Tidow, Rajiv Kumar, Peter Dreger, Thomas Luft

https://doi.org/10.3324/haematol.2018.202267

Disability related to chronic graft -versus-host disease after alternative donor hematopoietic cell transplantation

Giancarlo Fatobene, Barry E. Storer, Rachel B. Salit, Stephanie J. Lee, Paul J. Martin, Guang-Shing Cheng, Paul A. Carpenter, Gansuvd Balgansuren, Effie W. Petersdorf, Colleen Delaney, Brenda M. Sandmaier, Filippo Milano, Mary E. Flowers

https://doi.org/10.3324/haematol.2018.202754

Blood Transfusion

Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors

Michael A. Pulsipher, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, O’Susan F. Leitman, Hati Kobusingye, RaeAnne M. Besser, John P. Miller, Rebecca J. Drexler, Aly Abdel-Mageed, Ibrahim A. Ahmed, Luke P. Akard, Andrew S. Artz, Edward D. Ball, Ruthee-Lu Bayer, Carolyn Bigelow, Brian J. Bolwell, E. Randolph Broun, David C. Delgado, Katharine Duckworth, Christopher C. Dvorak, Theresa E. Hahn, Ann E. Haight, Parameswaran N. Hari, Brandon M. Hayes-Lattin, David A. Jacobsohn, Ann A. Jakubowski, Kimberly A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Michael Linenberger, Mark R. Litzow, Walter Longo, Margarida Magalhaes-Silverman, John M. McCarty, Joseph P. McGuirk, Shahram Mori, Vinod Parameswaran, Vinod K. Prasad, Scott D. Rowley, Witold B. Rybka, Indira Sahdev, Jeffrey R. Schriber, George B. Selby, Paul J. Shaughnessy, Shalini Shenoy, Thomas Spitzer, William T. Tse, Joseph P. Uberti, Madhuri Vusirikala, Edmund K. Waller, Daniel J. Weisdorf, Gregory A. Yanik, Willis H. Navarro, Mary M. Horowitz, Galen E. Switzer, Dennis L. Confer, Bronwen E. Shaw

https://doi.org/10.3324/haematol.2018.200121

Online Only Articles

Positive impact of molecular analysis on prognostic scores in essential thrombocythemia: a single center prospective cohort experience

Damien Luque Paz, Olivier Mansier, Jérémie Riou, Carole Conejero, Lydia Roy, Célia Belkhodja, Valérie Ugo, Stéphane Giraudier

https://doi.org/10.3324/haematol.2018.197699

Phase I/II trial of cladribine, high-dose cytarabine, mitoxantrone, and G-CSF with dose-escalated mitoxantrone for relapsed/refractory acute myeloid leukemia and other high-grade myeloid neoplasms

Anna B. Halpern, Megan Othus, Emily M. Huebner, Bart L. Scott, Paul C. Hendrie, Mary-Elizabeth M. Percival, Pamela S. Becker, Heather A. Smith, Vivian G. Oehler, Johnnie J. Orozco, Ryan D. Cassaday, Kelda M. Gardner, Tara L. Chen, Sarah A. Buckley, Kaysey F. Orlowski, Asma Anwar, Elihu H. Estey, Roland B. Walter

https://doi.org/10.3324/haematol.2018.204792

Extramedullary acute myeloid leukemia presenting in young adults demonstrates sensitivity to high-dose anthracycline: a subset analysis from ECOG-ACRIN 1900

Hugo F. Fernandez, Zhuoxin Sun, Mark R. Litzow, Selina M. Luger, Elisabeth Paietta, Janis Racevskis, Ross L. Levine, Jay P. Patel, Omar Abdel-Wahab, Rhett P. Ketterling, Gordon W. Dewald, John M. Bennett, Jacob M. Rowe, Hillard M. Lazarus, Martin S. Tallman

https://doi.org/10.3324/haematol.2018.197277

Phase I dose-escalation study of brentuximab-vedotin combined with dexamethasone, high-dose cytarabine and cisplatin, as salvage treatment in relapsed/refractory classical Hodgkin lymphoma: The HOVON/LLPC Transplant BRaVE study

Anton Hagenbeek, Hans Mooij, Josée Zijlstra, Pieternella Lugtenburg, Gustaaf van Imhoff, Marcel Nijland, Sanne Tonino, Martin Hutchings, Marjolein Spiering, Roberto Liu, Harm van Tinteren, Marie José Kersten

https://doi.org/10.3324/haematol.2018.196899

Targeted next generation sequencing reveals high mutation frequency of CREBBP, BCL2 and KMT2D in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

Solène M. Evrard, Sarah Péricart, David Grand, Nadia Amara, Frédéric Escudié, Julia Gilhodes, Pierre Bories, Alexandra Traverse-Glehen, Romain Dubois, Pierre Brousset, Marie Parrens, Camille Laurent

https://doi.org/10.3324/haematol.2018.198572

DUSP22-rearranged anaplastic lymphomas are characterized by specific morphological features and a lack of cytotoxic and JAK/STAT surrogate markers

Arantza Onaindia, Sonia González de Villambrosía, Lucía Prieto-Torres, Socorro M Rodríguez-Pinilla, Santiago Montes-Moreno, Carmen González-Vela, Miguel A Piris

https://doi.org/10.3324/haematol.2018.205880

Clinical presentation determines selection of patients for initial observation in mantle cell lymphoma

Anita Kumar, Zhitao Ying, Anna Alperovich, Ahmet Dogan, Paul Hamlin, Craig Moskowitz, Janine Pichardo, Carol Portlock, Fushen Sha, Andrew D. Zelenetz, Zhigang Zhang, Esther Drill, Kaitlin Woo, Anas Younes

https://doi.org/10.3324/haematol.2018.201350

Case Report

Serendipity: decitabine monotherapy induced complete molecular response in a 77-year-old patient with acute promyelocytic leukemia

Ramzi Abboud, Se Young Han, Eric J. Duncavage, Amanda F. Cashen, Cara Lunn Shirai, John S. Welch, John F. DiPersio, Camille N. Abboud

https://doi.org/10.3324/haematol.2018.209478

Transmission of diffuse large B-cell lymphoma by an allogeneic stem-cell transplant

Shamzah Araf, Jun Wang, Margaret Ashton-Key, Koorosh Korfi, Doriana Di Bella, Ana Rio-Machin, Mariette Odabashian, Vipul Foria, Ming-Qing Du, Francesco Cucco, Sharon Barrans, Peter Johnson, Sophie R. Laird, Andrew M. Fisher, Jonathan O. Cullis, Trevor A. Graham, Jessica Okosun, Jude Fitzgibbon, Laura Chiecchio

https://doi.org/10.3324/haematol.2018.196907

Comments

Obituary

Francesco Lo Coco, a distinguished hematologist and a friend

On behalf of the SIE, SIES and GIMEMA:, Paolo Corradini, Pellegrino Musto, Marco Vignetti

https://doi.org/10.3324/haematol.2019.222356