March, 2019
No. 104 (3)

Editorials

Review Articles

Articles

Hematopoiesis

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis (2508 Online Views)

Annas Al-Sharea, Man K. S. Lee, Alexandra Whillas, Danielle L. Michell, Waled A. Shihata, Alyce J. Nicholls, Olivia D. Cooney, Michael J. Kraakman, Camilla Bertuzzo Veiga, Ann-Maree Jefferis, Kristy Jackson, Prabhakara R. Nagareddy, Gavin Lambert, Connie H. Y. Wong, Karen L. Andrews, Geoff A. Head, Jaye Chin-Dusting, Andrew J. Murphy

https://doi.org/10.3324/haematol.2018.192898

Red Cell Biology & its Disorders

Association of anemia with health-related quality of life and survival: a large population-based cohort study (5552 Online Views)

Hanneke J.C.M. Wouters, Melanie M. van der Klauw, Theo de Witte, Reinhard Stauder, Dorine W. Swinkels, Bruce H.R. Wolffenbuttel, Gerwin Huls

https://doi.org/10.3324/haematol.2018.195552

Sotatercept, a novel transforming growth factor β ligand trap, improves anemia in β-thalassemia: a phase II, open-label, dose-finding study (3310 Online Views)

Maria Domenica Cappellini, John Porter, Raffaella Origa, Gian Luca Forni, Ersi Voskaridou, Frédéric Galactéros, Ali T. Taher, Jean-Benoît Arlet, Jean-Antoine Ribeil, Maciej Garbowski, Giovanna Graziadei, Chantal Brouzes, Michaela Semeraro, Abderrahmane Laadem, Dimana Miteva, Jun Zou, Victoria Sung, Tatiana Zinger, Kenneth M. Attie, Olivier Hermine

https://doi.org/10.3324/haematol.2018.198887

Myelodysplastic Syndromes

The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes (1740 Online Views)

Peipei Lin, Yanling Ren, Xiaomei Yan, Yingwan Luo, Hua Zhang, Meenu Kesarwani, Jiachen Bu, Di Zhan, Yile Zhou, Yuting Tang, Shuanghong Zhu, Weilai Xu, Xinping Zhou, Chen Mei, Liya Ma, Li Ye, Chao Hu, Mohammad Azam, Wei Ding, Jie Jin, Gang Huang, Hongyan Tong

https://doi.org/10.3324/haematol.2018.197749

Dyserythropoiesis evaluated by the RED score and hepcidin:ferritin ratio predicts response to erythropoietin in lower-risk myelodysplastic syndromes (1436 Online Views)

Sophie Park, Olivier Kosmider, Frédéric Maloisel, Bernard Drenou, Nicolas Chapuis, Thibaud Lefebvre, Zoubida Karim, Hervé Puy, Anne Sophie Alary, Sarah Ducamp, Frédérique Verdier, Cécile Bouilloux, Alice Rousseau, Marie-Christine Jacob, Agathe Debliquis, Agnes Charpentier, Emmanuel Gyan, Bruno Anglaret, Cecile Leyronnas, Selim Corm, Borhane Slama, Stephane Cheze, Kamel Laribi, Shanti Amé, Christian Rose, Florence Lachenal, Andrea Toma, Gian Matteo Pica, Martin Carre, Frédéric Garban, Clara Mariette, Jean-Yves Cahn, Mathieu Meunier, Olivier Herault, Pierre Fenaux, Orianne Wagner-Ballon, Valerie Bardet, Francois Dreyfus, Michaela Fontenay

https://doi.org/10.3324/haematol.2018.203158

Acute Myeloid Leukemia

Clinical implications of subclonal TP53 mutations in acute myeloid leukemia (4061 Online Views)

Katharina T. Prochazka, Gudrun Pregartner, Frank G. Rücker, Ellen Heitzer, Gabriel Pabst, Albert Wölfler, Armin Zebisch, Andrea Berghold, Konstanze Döhner, Heinz Sill

https://doi.org/10.3324/haematol.2018.205013

Haploidentical versus unrelated allogeneic stem cell transplantation for relapsed/refractory acute myeloid leukemia: a report on 1578 patients from the Acute Leukemia Working Party of the EBMT (2404 Online Views)

Eolia Brissot, Myriam Labopin, Gerhard Ehninger, Matthias Stelljes, Arne Brecht, Arnold Ganser, Johanna Tischer, Nicolaus Kröger, Boris Afanasyev, Jürgen Finke, Ahmet Elmaagacli, Herman Einsele, Mohamad Mohty, Arnon Nagler

https://doi.org/10.3324/haematol.2017.187450

Acute Lymphoblastic Leukemia

ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells (1473 Online Views)

Federica Portale, Giulia Cricrì, Silvia Bresolin, Monica Lupi, Stefania Gaspari, Daniela Silvestri, Barbara Russo, Noemi Marino, Paolo Ubezio, Fabio Pagni, Patrizia Vergani, Geertruy Te Kronnie, Maria Grazia Valsecchi, Franco Locatelli, Carmelo Rizzari, Andrea Biondi, Erica Dander, Giovanna D’Amico

https://doi.org/10.3324/haematol.2018.188664

Targeting the endoplasmic reticulum-mitochondria interface sensitizes leukemia cells to cytostatics (1263 Online Views)

Fabian Koczian, Olga Nagło, Jan Vomacka, Binje Vick, Phil Servatius, Themistoklis Zisis, Britta Hettich, Uli Kazmaier, Stephan A. Sieber, Irmela Jeremias, Stefan Zahler, Simone Braig

https://doi.org/10.3324/haematol.2018.197368

Trypsin-encoding PRSS1-PRSS2 variations influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report (1880 Online Views)

Benjamin O. Wolthers, Thomas L. Frandsen, Chirag J. Patel, Rachid Abaji, Andishe Attarbaschi, Shlomit Barzilai, Antonella Colombini, Gabriele Escherich, Marie Grosjean, Maja Krajinovic, Eric Larsen, Der-Cherng Liang, Anja Möricke, Kirsten K. Rasmussen, Sujith Samarasinghe, Lewis B. Silverman, Inge M. van der Sluis, Martin Stanulla, Morten Tulstrup, Rachita Yadav, Wenjian Yang, Ester Zapotocka, Ramneek Gupta, Kjeld Schmiegelow

https://doi.org/10.3324/haematol.2018.199356

Hodgkin Lymphoma

Chronic Lymphocytic Leukemia

Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia (3148 Online Views)

Neus Giménez, Alejandra Martínez-Trillos, Arnau Montraveta, Mónica Lopez-Guerra, Laia Rosich, Ferran Nadeu, Juan G. Valero, Marta Aymerich, Laura Magnano, Maria Rozman, Estella Matutes, Julio Delgado, Tycho Baumann, Eva Gine, Marcos González, Miguel Alcoceba, M. José Terol, Blanca Navarro, Enrique Colado, Angel R. Payer, Xose S. Puente, Carlos López-Otín, Armando Lopez-Guillermo, Elias Campo, Dolors Colomer, Neus Villamor

https://doi.org/10.3324/haematol.2018.196931

Hemostasis

Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA (2733 Online Views)

Nina Borràs, Gerard Orriols, Javier Batlle, Almudena Pérez-Rodríguez, Teresa Fidalgo, Patricia Martinho, María Fernanda López-Fernández, Ángela Rodríguez-Trillo, Esther Lourés, Rafael Parra, Carme Altisent, Ana Rosa Cid, Santiago Bonanad, Noelia Cabrera, Andrés Moret, María Eva Mingot-Castellano, Nira Navarro, Rocío Pérez-Montes, Sally Marcellin, Ana Moreto, Sonia Herrero, Inmaculada Soto, Núria Fernández-Mosteirín, Víctor Jiménez-Yuste, Nieves Alonso, Aurora de Andrés-Jacob, Emilia Fontanes, Rosa Campos, María José Paloma, Nuria Bermejo, Ruben Berrueco, José Mateo, Karmele Arribalzaga, Pascual Marco, Ángeles Palomo, Nerea Castro Quismondo, Belén Iñigo, María del Mar Nieto, Rosa Vidal, María Paz Martínez, Reyes Aguinaco, Jesús María Tenorio, María Ferreiro, Javier García-Frade, Ana María Rodríguez-Huerta, Jorge Cuesta, Ramón Rodríguez-González, Faustino García-Candel, Manuela Dobón, Carlos Aguilar, Francisco Vidal, Irene Corrales

https://doi.org/10.3324/haematol.2018.203166

Coagulation & its Disorders

Selective loss of function variants in IL6ST cause Hyper-IgE syndrome with distinct impairments of T-cell phenotype and function (3336 Online Views)

Tala Shahin, Dominik Aschenbrenner, Deniz Cagdas, Sevgi Köstel Bal, Cecilia Domínguez Conde, Wojciech Garncarz, David Medgyesi, Tobias Schwerd, Betül Karaatmaca, Pınar Gur Cetinkaya, Saliha Esenboga, Stephen R. F. Twigg, Andrew Cant, Andrew O. M. Wilkie, Ilhan Tezcan, Holm H. Uhlig, Kaan Boztug

https://doi.org/10.3324/haematol.2018.194233

Stem Cell Transplantation

T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing (1468 Online Views)

Cornelia S. Link-Rachner, Anne Eugster, Elke Rücker-Braun, Falk Heidenreich, Uta Oelschlägel, Andreas Dahl, Christian Klesse, Matthias Kuhn, Jan Moritz Middeke, Martin Bornhäuser, Ezio Bonifacio, Johannes Schetelig

https://doi.org/10.3324/haematol.2018.199802

Blood Transfusion

Somatic mosaicisms of chromosome 1 at two different stages of ontogenetic development detected by Rh blood group discrepancies (2266 Online Views)

Eva-Maria Dauber, Wolfgang R. Mayr, Hein Hustinx, Marlies Schönbacher, Holger Budde, Tobias J. Legler, Margit König, Oskar A. Haas, Gerhard Fritsch, Günther F. Körmöczi

https://doi.org/10.3324/haematol.2018.201293

Online Only Articles

Letters to the Editor

CD38 as a therapeutic target for adult acute myeloid leukemia and T-cell acute lymphoblastic leukemia (3696 Online Views)

Jyoti Naik, Maria Themeli, Regina de Jong-Korlaar, Ruud W.J. Ruiter, Pino J Poddighe, Huipin Yuan, Joost D. de Bruijn, Gert J. Ossenkoppele, Sonja Zweegman, Linda Smit, Tuna Mutis, Anton C.M. Martens, Niels W.C.J. van de Donk, Richard W.J. Groen

https://doi.org/10.3324/haematol.2018.192757

DNA methylation profiling of hepatosplenic T-cell lymphoma (1016 Online Views)

Anke K. Bergmann, Virginie Fataccioli, Giancarlo Castellano, Nadine Martin-Garcia, Laura Pelletier, Ole Ammerpohl, Juri Bergmann, Jaydeep Bhat, Enrique Carrillo-de Santa Pau, José I. Martín-Subero, Andrea B. Moffitt, Alfonso Valencia, Hans-Heinrich Oberg, Daniela Wesch, Sandrine Jayne, Martin J.S. Dyer, Dieter Kabelitz, Philippe Gaulard, Reiner Siebert

https://doi.org/10.3324/haematol.2018.196196

Impaired factor XIII activation in patients with congenital afibrinogenemia (855 Online Views)

Françoise Bridey, Claude Négrier, Cedric Duval, Robert Ariëns, Philippe de Moerloose, Alessandro Casini

https://doi.org/10.3324/haematol.2018.203901

Molecular analysis of a CD19-negative diffuse large B-cell lymphoma (1560 Online Views)

Lorric Delage, Delphine Manzoni, Charles Quinquenet, Juliette Fontaine, Alizée Maarek, Kaddour Chabane, Isabelle Mosnier, Sandrine Hayette, Evelyne Callet-Bauchu, Beatrice Grange, Adriana Plesa, Pierre Sujobert

https://doi.org/10.3324/haematol.2018.203521

T-cell large granular lymphocyte leukemia transfomation into aggressive T-cell lymphoma: a report of two cases with molecular characterization (1362 Online Views)

Maya Belhadj, Dalila Mansour, Sophie Kaltenbach, Benedicte Deau-Fischer, Patricia Franchi, Jérôme Tamburini, Nicolas Chapuis, Diane Damotte, Olivier Kosmider, Barbara Burroni, Didier Bouscary

https://doi.org/10.3324/haematol.2018.205542

Comment

Letters to the Editor

Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice (1070 Online Views)

Irene Artuso, Mariateresa Pettinato, Antonella Nai, Alessia Pagani, Ugo Sardo, Benjamin Billoré, Maria Rosa Lidonnici, Cavan Bennett, Giacomo Mandelli, Sant-Rayn Pasricha, Giuliana Ferrari, Clara Camaschella, Léon Kautz, Laura Silvestri

https://doi.org/10.3324/haematol.2018.199810

A gain of function variant in PIEZO1 (E756del) and sickle cell disease (1396 Online Views)

Helen Rooks, John Brewin, Kate Gardner, Subarna Chakravorty, Stephan Menzel, Anke Hannemann, John Gibson, David C. Rees

https://doi.org/10.3324/haematol.2018.202697

Highly sensitive methods are required to detect mutations in histiocytoses (1276 Online Views)

Sarah Melloul, Zofia Hélias-Rodzewicz, Fleur Cohen-Aubart, Frédéric Charlotte, Sylvie Fraitag, Nathalie Terrones, Quentin Riller, Thibaud Chazal, Sébastien Héritier, Anne Moreau, Marianne Kambouchner, Marie Christine Copin, Jean Donadieu, Valérie Taly, Zahir Amoura, Julien Haroche, Jean François Emile

https://doi.org/10.3324/haematol.2018.201194

Perspective Articles