May, 2019
No. 104 (5)

Editorials

Perspective Articles

Review Articles

CRISPR to fix bad blood: a new tool in basic and clinical hematology

Elisa González-Romero, Cristina Martínez-Valiente, Cristian García-Ruiz, Rafael P. Vázquez-Manrique, José Cervera, Alejandra Sanjuan-Pla

https://doi.org/10.3324/haematol.2018.211359

Articles

Chronic Lymphocytic Leukemia

The involvement of microRNA in the pathogenesis of Richter syndrome

Katrien Van Roosbroeck, Recep Bayraktar, Steliana Calin, Johannes Bloehdorn, Mihnea Paul Dragomir, Keishi Okubo, Maria Teresa Sabrina Bertilaccio, Simonetta Zupo, M. James You, Gianluca Gaidano, Davide Rossi, Shih-Shih Chen, Nicholas Chiorazzi, Philip A. Thompson, Alessandra Ferrajoli, Francesco Bertoni, Stephan Stilgenbauer, Michael J. Keating, George A. Calin

https://doi.org/10.3324/haematol.2018.203828

Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies

Aoula Al-Zebeeby, Meike Vogler, Mateus Milani, Caitlin Richards, Ahoud Alotibi, Georgia Greaves, Martin J.S. Dyer, Gerald M. Cohen, Shankar Varadarajan

https://doi.org/10.3324/haematol.2018.204701

Plasma Cell Disorders

Efficacy of first-line treatments for multiple myeloma patients not eligible for stem cell transplantation: a network meta-analysis

Hedwig M. Blommestein, Chrissy H.Y. van Beurden-Tan, Margreet G. Franken, Carin A. Uyl-de Groot, Pieter Sonneveld, Sonja Zweegman

https://doi.org/10.3324/haematol.2018.206912

Platelet Biology & its Disorders

Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia

Tadbir K. Bariana, Veerle Labarque, Jessica Heremans, Chantal Thys, Mara De Reys, Daniel Greene, Benjamin Jenkins, Luigi Grassi, Denis Seyres, Frances Burden, Deborah Whitehorn, Olga Shamardina, Sofia Papadia, Keith Gomez, NIHR BioResource, Chris Van Geet, Albert Koulman, Willem H. Ouwehand, Cedric Ghevaert, Mattia Frontini, Ernest Turro, Kathleen Freson

https://doi.org/10.3324/haematol.2018.204784

Coagulation & Its Disorders

Prevention of the anti-factor VIII memory B-cell response by inhibition of Bruton tyrosine kinase in experimental hemophilia A

Sandrine Delignat, Jules Russick, Bagirath Gangadharan, Julie Rayes, Mathieu Ing, Jan Voorberg, Srinivas V. Kaveri, Sébastien Lacroix-Desmazes

https://doi.org/10.3324/haematol.2018.200279

Stem Cell Transplantation

HLA discrepancy between graft and host rather than that graft and first donor impact the second transplant outcome

Yoshinobu Maeda, Tomotaka Ugai, Eisei Kondo, Kazuhiro Ikegame, Makoto Murata, Naoyuki Uchida, Toshihiro Miyamoto, Satoshi Takahashi, Kazuteru Ohashi, Hirohisa Nakamae, Takahiro Fukuda, Makoto Onizuka, Tetsuya Eto, Shuichi Ota, Makoto Hirokawa, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshinobu Kanda, Junya Kanda

https://doi.org/10.3324/haematol.2018.204438

Cell Therapy & Immunotherapy

Quality of Life

Randomized controlled trial of individualized treatment summary and survivorship care plans for hematopoietic cell transplantation survivors

Navneet S. Majhail, Elizabeth Murphy, Purushottam Laud, Jaime M. Preussler, Ellen M. Denzen, Beatrice Abetti, Alexia Adams, RaeAnne Besser, Linda J. Burns, Jan Cerny, Rebecca Drexler, Theresa Hahn, Lensa Idossa, Balkrishna Jahagirdar, Naynesh Kamani, Alison Loren, Deborah Mattila, Joseph McGuirk, Heather Moore, Jana Reynolds, Wael Saber, Lizette Salazar, Barry Schatz, Patrick Stiff, John R. Wingard, Karen L Syrjala, K. Scott Baker

https://doi.org/10.3324/haematol.2018.203919

Hematopoiesis

Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow

Zhijie Wu, Shouguo Gao, Xin Zhao, Jinguo Chen, Keyvan Keyvanfar, Xingmin Feng, Sachiko Kajigaya, Neal S. Young

https://doi.org/10.3324/haematol.2018.208926

Red Cell Biology & Its Disorders

Finely-tuned regulation of AMP-activated protein kinase is crucial for human adult erythropoiesis

Meriem Ladli, Cyrielle Richard, Lilia Cantero Aguilar, Sarah Ducamp, Sabrina Bondu, Pierre Sujobert, Jérôme Tamburini, Catherine Lacombe, Nabih Azar, Marc Foretz, Yael Zermati, Patrick Mayeux, Benoit Viollet, Frédérique Verdier

https://doi.org/10.3324/haematol.2018.191403

Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule

Elisabetta Lombardi, Alessandro Matte, Antonio M. Risitano, Daniel Ricklin, John D. Lambris, Denise De Zanet, Sakari T. Jokiranta, Nicola Martinelli, Cinzia Scambi, Gianluca Salvagno, Zeno Bisoffi, Chiara Colato, Angela Siciliano, Oscar Bortolami, Mario Mazzuccato, Francesco Zorzi, Luigi De Marco, Lucia De Franceschi

https://doi.org/10.3324/haematol.2018.198622

Myelodysplastic Syndromes

Optimized EBMT transplant-specific risk score in myelodysplastic syndromes after allogeneic stem-cell transplantation

Nico Gagelmann, Diderik-Jan Eikema, Matthias Stelljes, Dietrich Beelen, Liesbeth de Wreede, Ghulam Mufti, Nina Simone Knelange, Dietger Niederwieser, Lone S. Friis, Gerhard Ehninger, Arnon Nagler, Ibrahim Yakoub-Agha, Ellen Meijer, Per Ljungman, Johan Maertens, Lothar Kanz, Lucia Lopez-Corral, Arne Brecht, Charles Craddock, Jürgen Finke, Jan J. Cornelissen, Paolo Bernasconi, Patrice Chevallier, Jorge Sierra, Marie Robin, Nicolaus Kröger

https://doi.org/10.3324/haematol.2018.200808

Myeloproliferative Neoplasms

Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms

Alicia Arenas Cortés, Rosa Ayala Diaz, Pilar Hernández-Campo, Julián Gorrochategui, Daniel Primo, Alicia Robles, María Luz Morales, Joan Ballesteros, Inmaculada Rapado, Miguel Gallardo, María Linares, Joaquín Martínez-López

https://doi.org/10.3324/haematol.2018.201038

EXPAND, a dose-finding study of ruxolitinib in patients with myelofibrosis and low platelet counts: 48-week follow-up analysis

Alessandro M. Vannucchi, Peter A. W. te Boekhorst, Claire N. Harrison, Guangsheng He, Marianna Caramella, Dietger Niederwieser, Françoise Boyer-Perrard, Minghui Duan, Nathalie Francillard, Betty Molloy, Monika Wroclawska, Heinz Gisslinger

https://doi.org/10.3324/haematol.2018.204602

Chronic Myeloid Leukemia

Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV

Christian Michel, Andreas Burchert, Andreas Hochhaus, Susanne Saussele, Andreas Neubauer, Michael Lauseker, Stefan W. Krause, Hans-Jochem Kolb, Dieter Kurt Hossfeld, Christoph Nerl, Gabriela M. Baerlocher, Dominik Heim, Tim H Brümmendorf, Alice Fabarius, Claudia Haferlach, Brigitte Schlegelberger, Leopold Balleisen, Maria-Elisabeth Goebeler, Mathias Hänel, Anthony Ho, Jolanta Dengler, Christiane Falge, Robert Möhle, Stephan Kremers, Michael Kneba, Frank Stegelmann, Claus-Henning Köhne, Hans-Walter Lindemann, Cornelius F. Waller, Karsten Spiekermann, Wolfgang E. Berdel, Lothar Müller, Matthias Edinger, Jiri Mayer, Dietrich W. Beelen, Martin Bentz, Hartmut Link, Bernd Hertenstein, Roland Fuchs, Martin Wernli, Frank Schlegel, Rudolf Schlag, Maike de Wit, Lorenz Trümper, Holger Hebart, Markus Hahn, Jörg Thomalla, Christof Scheid, Philippe Schafhausen, Walter Verbeek, Michael J. Eckart, Winfried Gassmann, Michael Schenk, Peter Brossart, Thomas Wündisch, Thomas Geer, Stephan Bildat, Erhardt Schäfer, Joerg Hasford, Rüdiger Hehlmann, Markus Pfirrmann

https://doi.org/10.3324/haematol.2018.206797

Acute Myeloid Leukemia

The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia

Dana Yehudai, Sanduni U. Liyanage, Rose Hurren, Biljana Rizoska, Mark Albertella, Marcela Gronda, Danny V Jeyaraju, Xiaoming Wang, Samir H. Barghout, Neil MacLean, Thirushi P. Siriwardena, Yulia Jitkova, Paul Targett-Adams, Aaron D. Schimmer

https://doi.org/10.3324/haematol.2018.195172

The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells

Isabella Spinello, Ernestina Saulle, Maria Teresa Quaranta, Luca Pasquini, Elvira Pelosi, Germana Castelli, Tiziana Ottone, Maria Teresa Voso, Ugo Testa, Catherine Labbaye

https://doi.org/10.3324/haematol.2018.199661

Acute Lymphoblastic Leukemia

Replacing cyclophosphamide/cytarabine/mercaptopurine with cyclophosphamide/etoposide during consolidation/delayed intensification does not improve outcome for pediatric B-cell acute lymphoblastic leukemia: a report from the COG

Michael J. Burke, Wanda L. Salzer, Meenakshi Devidas, Yunfeng Dai, Lia Gore, Joanne M. Hilden, Eric Larsen, Karen R. Rabin, Patrick A. Zweidler-McKay, Michael J. Borowitz, Brent Wood, Nyla A. Heerema, Andrew J. Carroll, Naomi Winick, William L. Carroll, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger

https://doi.org/10.3324/haematol.2018.204545

Non-Hodgkin Lymphoma

Mogamulizumab versus investigator’s choice of chemotherapy regimen in relapsed/refractory adult T-cell leukemia/lymphoma

Adrienne A. Phillips, Paul A. Fields, Olivier Hermine, Juan C. Ramos, Brady E. Beltran, Juliana Pereira, Farooq Wandroo, Tatyana Feldman, Graham P. Taylor, Ahmed Sawas, Jeffrey Humphrey, Michael Kurman, Junji Moriya, Karen Dwyer, Mollie Leoni, Kevin Conlon, Lucy Cook, Jason Gonsky, Steven M. Horwitz

https://doi.org/10.3324/haematol.2018.205096

Online Only Articles

Letters to the Editor

A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp

Maria G. Rotordam, Elisa Fermo, Nadine Becker, Wilma Barcellini, Andrea Brüggemann, Niels Fertig, Stéphane Egée, Markus Rapedius, Paola Bianchi, Lars Kaestner

https://doi.org/10.3324/haematol.2018.201160

The population dynamics of hemoglobins A, A2, F and S in the context of the hemoglobinopathies HbS and α-thalassemia in Kenyan infants

Alex W. Macharia, Sophie Uyoga, Carolyne Ndila, Gideon Nyutu, Johnstone Makale, Metrine Tendwa, Emily Nyatichi, John Ojal, Sarah Atkinson, Thomas N. Williams

https://doi.org/10.3324/haematol.2018.199596

Clinical and molecular features of acute promyelocytic leukemia with variant retinoid acid receptor fusions

Lijun Wen, Yang Xu, Li Yao, Nana Wang, Qinrong Wang, Tianhui Liu, Jinlan Pan, Jiannong Cen, Huifeng Zhou, Miao Miao, Yang W. Shao, Xiaonan Wang, Xiaoxia Wang, Changgeng Ruan, Depei Wu, Suning Chen

https://doi.org/10.3324/haematol.2018.205369

Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias

Zhen-Tang Lao, Ling-Wen Ding, Omer An, Norimichi Hattori, Qiao-Yang Sun, Kar-Tong Tan, Anand Mayakonda, Wong Gee Chuan, Vikas Madan, De-Chen Lin, Henry Yang, H. Phillip Koeffler

https://doi.org/10.3324/haematol.2018.202911

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

Charles E. de Bock, Michelle Down, Kinsha Baidya, Bram Sweron, Andrew W. Boyd, Mark Fiers, Gordon F. Burns, Timothy J. Molloy, Richard B. Lock, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jan Cools, Jeff Holst, Rick F. Thorne

https://doi.org/10.3324/haematol.2018.198424

Long-term real-world results of ibrutinib therapy in patients with relapsed or refractory chronic lymphocytic leukemia: 30-month follow up of the Swedish compassionate use cohort

Maria Winqvist, Per-Ola Andersson, Anna Asklid, Karin Karlsson, Claes Karlsson, Birgitta Lauri, Jeanette Lundin, Mattias Mattsson, Stefan Norin, Anna Sandstedt, Richard Rosenquist, Florentin Späth, Lotta Hansson, Anders Österborg, for the Swedish CLL Group

https://doi.org/10.3324/haematol.2018.198820

Ibrutinib for the treatment of relapsed/refractory mantle cell lymphoma: extended 3.5-year follow up from a pooled analysis

Simon Rule, Martin Dreyling, Andre Goy, Georg Hess, Rebecca Auer, Brad Kahl, José-Ángel Hernández-Rivas, Keqin Qi, Sanjay Deshpande, Lori Parisi, Michael Wang

https://doi.org/10.3324/haematol.2018.205229

A prospective description of HIV-associated multicentric Castleman disease in Malawi

Tamiwe Tomoka, Matthew S. Painschab, Nathan D. Montgomery, Ryan Seguin, Maurice Mulenga, Bongani Kaimila, Edwards Kasonkanji, Takondwa Zuze, Richard Nyasosela, Ruth Nyirenda, Maria Chikasema, Blessings Tewete, Asekanadziwa Mtangwanika, Sarah Chiyoyola, Fred Chimzimu, Coxcilly Kampani, Yuri Fedoriw, Satish Gopal

https://doi.org/10.3324/haematol.2018.204479

Case Reports

Leukemic presentation of ALK-positive anaplastic large cell lymphoma with a novel partner, poly(A) binding protein cytoplasmic 1 (PABPC1), responding to single-agent crizotinib

Dylan Graetz, Kristine R. Crews, Elizabeth M. Azzato, Ravi K. Singh, Susana Raimondi, John Mason, Marcus Valentine, Charles G. Mullighan, Ashley Holland, Hiroto Inaba, Vasiliki Leventaki

https://doi.org/10.3324/haematol.2018.215103

Venetoclax penetrates in cerebrospinal fluid and may be effective in chronic lymphocytic leukemia with central nervous system involvement

Gianluigi Reda, Ramona Cassin, Gabriela Dovrtelova, Cristina Matteo, Juri Giannotta, Maurizio D’Incalci, Agostino Cortelezzi, Massimo Zucchetti

https://doi.org/10.3324/haematol.2018.213157

Venetoclax plus rituximab or obinutuzumab after allogeneic hematopoietic stem cell transplantation in chronic lymphocytic leukemia

Othman Al-Sawaf, Carmen Diana Herling, Udo Holtick, Christoph Scheid, Paula Cramer, Stephanie Sasse, Bastian von Tresckow, Armin Tuchscherer, Kirsten Fischer, Barbara Eichhorst, Michael Hallek, Lukas P. Frenzel

https://doi.org/10.3324/haematol.2018.212837

Comments

Retraction

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells

Beibei Zhang, Pilar Ayuda-Durán, Laure Piechaczyk, Yngvar Fløisand, Mireia Mayoral Safont, Ida Tveit Karlsen, Zina Fandalyuk, Dagim Tadele, Pepijn van Mierlo, Alexander D. Rowe, Joseph M. Robertson, Bjørn Tore Gjertsen, Emmet McCormack, Jorrit M. Enserink

https://doi.org/10.3324/haematol.2019.220533