August, 2018
No. 103 (8)

Editorials

Review Articles

Articles

Hematopoiesis

CARD10, a CEBPE target involved in granulocytic differentiation

Pavithra Shyamsunder, Haresh Sankar, Anand Mayakonda, Lin Han, Hazimah Binte Mohd Nordin, Teoh Weoi Woon, Mahalakshmi Shanmugasundaram, Pushkar Dakle, Vikas Madan, H. Phillip Koeffler

https://doi.org/10.3324/haematol.2018.190280

Bone Marrow Failure

Natural history of GATA2 deficiency in a survey of 79 French and Belgian patients

Jean Donadieu, Marie Lamant, Claire Fieschi, Flore Sicre de Fontbrune, Aurélie Caye, Marie Ouachee, Blandine Beaupain, Jacinta Bustamante, Hélène A. Poirel, Bertrand Isidor, Eric Van Den Neste, Antoine Neel, Stanislas Nimubona, Fabienne Toutain, Vincent Barlogis, Nicolas Schleinitz, Thierry Leblanc, Pierre Rohrlich, Felipe Suarez, Dana Ranta, Wadih Abou Chahla, Bénédicte Bruno, Louis Terriou, Sylvie Francois, Bruno Lioure, Guido Ahle, Françoise Bachelerie, Claude Preudhomme, Eric Delabesse, Hélène Cave, Christine Bellanné-Chantelot, Marlène Pasquet

https://doi.org/10.3324/haematol.2017.181909

Myelodysplastic Syndrome

The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34+CD123+ cells from acute myeloid leukemia/myelodysplastic syndrome patients and healthy donors

Rajeswaran Mani, Swagata Goswami, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tran, Xiaokui Mo, Amber Gordon, Donna Bucci, David M. Lucas, Alice Mims, Christopher Brooks, Adrienne Dorrance, Alison Walker, William Blum, John C. Byrd, Gerard Lozanski, Sumithira Vasu, Natarajan Muthusamy

https://doi.org/10.3324/haematol.2018.188193

Chronic Myeloid Leukemia

Safety and efficacy of second-line bosutinib for chronic phase chronic myeloid leukemia over a five-year period: final results of a phase I/II study

Carlo Gambacorti-Passerini, Jorge E. Cortes, Jeff H. Lipton, Hagop M. Kantarjian, Dong-Wook Kim, Philippe Schafhausen, Rocco Crescenzo, Nathalie Bardy-Bouxin, Mark Shapiro, Kay Noonan, Eric Leip, Liza DeAnnuntis, Tim H. Brümmendorf, H. Jean Khoury

https://doi.org/10.3324/haematol.2017.171249

Acute Myeloid Leukemia

Phase I trial of plerixafor combined with decitabine in newly diagnosed older patients with acute myeloid leukemia

Gail J. Roboz, Ellen K. Ritchie, Yulia Dault, Linda Lam, Danielle C. Marshall, Nicole M. Cruz, Hsiao-Ting C. Hsu, Duane C. Hassane, Paul J. Christos, Cindy Ippoliti, Joseph M. Scandura, Monica L. Guzman

https://doi.org/10.3324/haematol.2017.183418

Outcomes of hematopoietic stem cell transplantation from unmanipulated haploidentical versus matched sibling donor in patients with acute myeloid leukemia in first complete remission with intermediate or high-risk cytogenetics: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Dalila Salvatore, Myriam Labopin, Annalisa Ruggeri, Giorgia Battipaglia, Ardeshir Ghavamzadeh, Fabio Ciceri, Didier Blaise, William Arcese, Gerard Sociè, Jean Henri Bourhis, Maria Teresa Van Lint, Benedetto Bruno, Anne Huynh, Stella Santarone, Eric Deconinck, Mohamad Mohty, Arnon Nagler

https://doi.org/10.3324/haematol.2018.189258

Non-Hodgkin Lymphoma

Novel GPR34 and CCR6 mutation and distinct genetic profiles in MALT lymphomas of different sites

Sarah Moody, Joe Sneath Thompson, Shih-Sung Chuang, Hongxiang Liu, Markus Raderer, George Vassiliou, Iwona Wlodarska, Fangtian Wu, Sergio Cogliatti, Alistair Robson, Margaret Ashton-Key, Yingwen Bi, John Goodlad, Ming-Qing Du

https://doi.org/10.3324/haematol.2018.191601

End-of-treatment and serial PET imaging in primary mediastinal B-cell lymphoma following dose-adjusted EPOCH-R: a paradigm shift in clinical decision making

Christopher Melani, Ranjana Advani, Mark Roschewski, Kelsey M. Walters, Clara C. Chen, Lucia Baratto, Mark A. Ahlman, Milos D. Miljkovic, Seth M. Steinberg, Jessica Lam, Margaret Shovlin, Kieron Dunleavy, Stefania Pittaluga, Elaine S. Jaffe, Wyndham H. Wilson

https://doi.org/10.3324/haematol.2018.192492

Rituximab plus bendamustine as front-line treatment in frail elderly (>70 years) patients with diffuse large B-cell non-Hodgkin lymphoma: a phase II multicenter study of the Fondazione Italiana Linfomi

Sergio Storti, Michele Spina, Emanuela Anna Pesce, Flavia Salvi, Michele Merli, Alessia Ruffini, Giuseppina Cabras, Annalisa Chiappella, Emanuele Angelucci, Alberto Fabbri, Anna Marina Liberati, Monica Tani, Gerardo Musuraca, Annalia Molinari, Maria Pia Petrilli, Carmela Palladino, Rosanna Ciancia, Andrea Ferrario, Cristiana Gasbarrino, Federico Monaco, Vincenzo Fraticelli, Annalisa De Vellis, Francesco Merli, Stefano Luminari

https://doi.org/10.3324/haematol.2017.186569

A phase II multicenter study of the anti-CD19 antibody drug conjugate coltuximab ravtansine (SAR3419) in patients with relapsed or refractory diffuse large B-cell lymphoma previously treated with rituximab-based immunotherapy

Marek Trnĕný, Gregor Verhoef, Martin JS Dyer, Dina Ben Yehuda, Caterina Patti, Miguel Canales, Andrés Lopez, Farrukh T Awan, Paul G Montgomery, Andrea Janikova, Anna M Barbui, Kazimierz Sulek, Maria J Terol, John Radford, Anna Guidetti, Massimo Di Nicola, Laure Siraudin, Laurence Hatteville, Sandrine Schwab, Corina Oprea, Alessandro M Gianni

https://doi.org/10.3324/haematol.2017.168401

Plasma Cell Disorders

Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity in multiple myeloma bone disease

Joséphine Muller, Arnold Bolomsky, Sophie Dubois, Elodie Duray, Kathrin Stangelberger, Erwan Plougonven, Margaux Lejeune, Angélique Léonard, Caroline Marty, Ute Hempel, Frédéric Baron, Yves Beguin, Martine Cohen-Solal, Heinz Ludwig, Roy Heusschen, Jo Caers

https://doi.org/10.3324/haematol.2017.185397

Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease

Jingsong He, Qingxiao Chen, Huiyao Gu, Jing Chen, Enfan Zhang, Xing Guo, Xi Huang, Haimeng Yan, DongHua He, Yang Yang, Yi Zhao, Gang Wang, Huang He, Qing Yi, Zhen Cai

https://doi.org/10.3324/haematol.2017.181172

Quality of Life

Meaningful changes in end-of-life care among patients with myeloma

Oreofe O. Odejide, Ling Li, Angel M. Cronin, Anays Murillo, Paul G. Richardson, Kenneth C. Anderson, Gregory A. Abel

https://doi.org/10.3324/haematol.2018.187609

Cell Therapy & Immunotherapy

The early expansion of anergic NKG2Apos/CD56dim/CD16neg natural killer represents a therapeutic target in haploidentical hematopoietic stem cell transplantation

Alessandra Roberto, Clara Di Vito, Elisa Zaghi, Emilia Maria Cristina Mazza, Arianna Capucetti, Michela Calvi, Paolo Tentorio, Veronica Zanon, Barbara Sarina, Jacopo Mariotti, Stefania Bramanti, Elena Tenedini, Enrico Tagliafico, Silvio Bicciato, Armando Santoro, Mario Roederer, Emanuela Marcenaro, Luca Castagna, Enrico Lugli, Domenico Mavilio

https://doi.org/10.3324/haematol.2017.186619

Coagulation & Its Disorders

Dexamethasone promotes durable factor VIII-specific tolerance in hemophilia A mice via thymic mechanisms

Maria T. Georgescu, Paul C. Moorehead, Alice S. van Velzen, Kate Nesbitt, Birgit M. Reipert, Katharina N. Steinitz, Maria Schuster, Christine Hough, David Lillicrap

https://doi.org/10.3324/haematol.2018.189852

Online Only Articles

C/EBPγ is dispensable for steady-state and emergency granulopoiesis

Miroslava Kardosova, Polina Zjablovskaja, Petr Danek, Pavla Angelisova, Lorena Lobo de Figueiredo-Pontes, Robert S. Welner, Tomas Brdicka, Sanghoon Lee, Daniel G. Tenen, Meritxell Alberich-Jorda

https://doi.org/10.3324/haematol.2017.173781

GATA1s exerts developmental stage-specific effects in human hematopoiesis

Sofia Gialesaki, Anna Katharina Mahnken, Lena Schmid, Maurice Labuhn, Raj Bhayadia, Dirk Heckl, Jan-Henning Klusmann

https://doi.org/10.3324/haematol.2018.191338

miR-181a regulates erythroid enucleation via the regulation of Xpo7 expression

Amalia Avila Figueroa, James D. Fasano, Sandra Martinez-Morilla, Srividhya Venkatesan, Gary Kupfer, Shilpa M. Hattangadi

https://doi.org/10.3324/haematol.2017.171785

Concurrent treatment of aplastic anemia/paroxysmal nocturnal hemoglobinuria syndrome with immunosuppressive therapy and eculizumab: a UK experience

Morag Griffin, Austin Kulasekararaj, Sheyans Gandhi, Talha Munir, Stephen Richards, Louise Arnold, Nana Benson-Quarm, Nicola Copeland, Isabel Duggins, Kathryn Riley, Peter Hillmen, Judith Marsh, Anita Hill

https://doi.org/10.3324/haematol.2017.183046

Increased rituximab exposure does not improve response and outcome of patients with chronic lymphocytic leukemia after fludarabine, cyclophosphamide, rituximab. A French Innovative Leukemia Organization (FILO) study

Guillaume Cartron, Rémi Letestu, Caroline Dartigeas, Mira Tout, Béatrice Mahé, Anne-Laure Gagez, Emmanuelle Ferrant, Boris Guiu, Bruno Villemagne, Phan Letuan, Thérèse Aurran, Frédérique Orsini-Piocelle, Anne Banos, Pierre Feugier, Véronique Leblond, Sophie de Guibert, Olivier Tournilhac, Jehan Dupuis, Alain Delmer, Valérie Rouillé, David Ternant, Stéphane Leprêtre

https://doi.org/10.3324/haematol.2017.182352

RNA fusions involving CD28 are rare in peripheral T-cell lymphomas and concentrate mainly in those derived from follicular helper T cells

David Vallois, Aurélie Dupuy, Francois Lemonnier, George Allen, Edoardo Missiaglia, Virginie Fataccioli, Nicolas Ortonne, Aline Clavert, Richard Delarue, Marie-Christine Rousselet, Bettina Fabiani, Francisco Llamas-Gutierrez, Seishi Ogawa, Margot Thome, Young Hyeh Ko, Keisuke Kataoka, Philippe Gaulard, Laurence de Leval

https://doi.org/10.3324/haematol.2017.186767

Impact of age on genetics and treatment efficacy in follicular lymphoma

Stefan Alig, Vindi Jurinovic, Alessandro Pastore, Deepak Bararia, Sarah Häbe, Johannes C. Hellmuth, Robert Kridel, Randy Gascoyne, Christian Schmidt, Anna-Katharina Zöllner, Christian Buske, Martin Dreyling, Michael Unterhalt, Wolfgang Hiddemann, Eva Hoster, Oliver Weigert

https://doi.org/10.3324/haematol.2018.187773

Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients

Laurens E. Franssen, Inger S. Nijhof, Suzana Couto, Mark-David Levin, Gerard M.J. Bos, Annemiek Broijl, Saskia K. Klein, Yan Ren, Maria Wang, Harry R. Koene, Andries C. Bloem, Aart Beeker, Laura M. Faber, Ellen van der Spek, Reinier Raymakers, Roos J. Leguit, Pieter Sonneveld, Sonja Zweegman, Henk Lokhorst, Tuna Mutis, Anjan Thakurta, Xiaozhong Qian, Niels W.C.J. van de Donk

https://doi.org/10.3324/haematol.2017.186601

Germline JAK2 L611S mutation in a child with thrombocytosis

Bernard Aral, Martine Courtois, Sylviane Ragot, Valentin Bourgeois, Elodie Bottolier-Lemallaz, Claire Briandet, François Girodon

https://doi.org/10.3324/haematol.2018.188995

True, true unrelated? Coexistence of Waldenström macroglobulinemia and cardiac transthyretin amyloidosis

Avinainder Singh, Hallie I. Geller, Kevin M. Alexander, Robert F. Padera, Richard N. Mitchell, Sharmila Dorbala, Jorge J. Castillo, Rodney H. Falk

https://doi.org/10.3324/haematol.2018.190405

BRAF V600E mutation detected in a case of Rosai-Dorfman disease

Giancarlo Fatobene, Julien Haroche, Zofia Hélias-Rodzwicz, Frédéric Charlotte, Valérie Taly, Aliana Meneses Ferreira, André Néder Ramires Abdo, Vanderson Rocha, Jean-François Emile

https://doi.org/10.3324/haematol.2018.190934